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Additionally, the review discusses synthetic curcumin analogues that offer improved stability and potency. These innovative approaches demonstrate enhanced anticancer effects through pro-apoptotic, anti-proliferative, and anti-angiogenic mechanisms, often exhibiting synergistic activity with conventional therapies. This review aims to synthesize current evidence on the mechanisms and efficacy of these advanced curcumin-based strategies and provide future perspectives on their role as safe and effective options in oral oncology.<\/jats:p>","DOI":"10.1007\/s44445-026-00214-3","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:18:46Z","timestamp":1784283526000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel curcumin formulations for the therapy of oral cancer: a comprehensive review of mechanisms, delivery systems, and translational prospects"],"prefix":"10.1007","volume":"38","author":[{"given":"Sina","family":"Seyyedhamzeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Sharif","family":"Sharifani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda Sadr","family":"Shokriyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat","family":"Jafarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam Ghanbari","family":"Saray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Shirmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Shahidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Pourtaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Ghahremani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adib","family":"Biyari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Barjasteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-2765","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Pourhanifeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"214_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.9734\/bpi\/napr\/v2\/6386A","volume":"2","author":"N Agrawal","year":"2023","unstructured":"Agrawal N, Raza H, Jaiswal M, Lanjhiyana S, Sahoo MK (2023) A Review on the Pharmacological Effects of Curcumin in Diabetes, Cancer, and Neurodegenerative Diseases. 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