{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:21:58Z","timestamp":1782393718601,"version":"3.54.5"},"reference-count":134,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100023673","name":"Deanship of Scientific Research, Imam Mohammed Ibn Saud Islamic University","doi-asserted-by":"publisher","award":["IMSIU-DDRSP2501"],"award-info":[{"award-number":["IMSIU-DDRSP2501"]}],"id":[{"id":"10.13039\/501100023673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Saudi Pharm. J."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetes mellitus is a metabolic disease manifested by hyperglycemia, leading to critical health challenges in the\u00a0kidneys, eyes, nerves, and cardiovascular system.\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    (\n                    <jats:italic>Aloe barbadensis miller<\/jats:italic>\n                    ), a traditionally used herbal plant for treating various diseases, contains abundant bioactive compounds like alkaloids, flavonoids, acemannans, anthraquinones, chromones, anthrones, enzymes, vitamins, and minerals. These compounds are responsible for its diverse biological activities, including antimicrobial, anticancer, antidiabetic, anti-inflammatory, antioxidant, and hypolipidemic etc. This review primarily focuses on diabetes treatment through enzyme inhibition and modulation of metabolic parameters, with additional emphasis on diabetic complications including, the wound healing efficacy of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    . This study aims to evaluate the potential of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    in managing diabetes and minimizing the chances of diabetes-related organ damage. It was done by inhibition of several enzymes, including\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -glucosidase,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -amylase, dipeptidyl peptidase-4, pancreatic lipase, sucrase, and maltase enzymes, both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro.<\/jats:italic>\n                    The previous research revealed that administrating various doses of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    -based extracts via orally and non-orally routes in streptozotocin-induced diabetes offered metabolic regulation of signaling pathways like blood sugar, insulin, lipid profile, body weight, oxidative stress, TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , and IL-6 levels. Moreover, clinical data have confirmed\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    \u2019s potential in diabetic wound healing by promoting tissue regeneration mechanisms like angiogenesis, fibrinogenesis, collagen synthesis, and inflammation to reduce lesion size. These therapeutic properties highlight the hypoglycemic nature of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    , promising its potential for future clinical use as an alternative for diabetes treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s44446-026-00070-6","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:15:11Z","timestamp":1772622911000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic potential of Aloe vera in diabetes mellitus treatment: an update"],"prefix":"10.1007","volume":"34","author":[{"given":"Muhammad","family":"Adil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumayya","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-8056","authenticated-orcid":false,"given":"Matloob","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdi E. A.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"issue":"2","key":"70_CR1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1039\/C6MD00570E","volume":"8","author":"SM Abid","year":"2017","unstructured":"Abid SM, Aslam S, Zaib S, Bakht SM, Ahmad M, Athar MM, Gardiner JM, Iqbal J (2017) Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, in vitro bioevaluation and molecular docking studies. Medchemcomm 8(2):452\u2013464. https:\/\/doi.org\/10.1039\/C6MD00570E","journal-title":"Medchemcomm"},{"key":"70_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2022.100150","volume":"4","author":"AM Abubakar","year":"2022","unstructured":"Abubakar AM, Dibal NI, Attah MOO, Chiroma SM (2022) Exploring the antioxidant effects of Aloe vera: potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice. Pharmacol Res Mod Chin Med 4:100150. https:\/\/doi.org\/10.1016\/j.prmcm.2022.100150","journal-title":"Pharmacol Res Mod Chin Med"},{"issue":"2","key":"70_CR3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3329\/jsr.v13i2.50275","volume":"13","author":"F Afrin","year":"2021","unstructured":"Afrin F, Hossain M, Amin M, Islam M, Rokeya B (2021) Soluble dietary fiber from Aloe vera and lady\u2019s finger; effect on glucose absorption in type-2 diabetic model rats. J Sci Res 13(2):669\u2013678. https:\/\/doi.org\/10.3329\/jsr.v13i2.50275","journal-title":"J Sci Res"},{"issue":"8","key":"70_CR4","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1177\/000331978503600801","volume":"36","author":"OP Agarwal","year":"1985","unstructured":"Agarwal OP (1985) Prevention of atheromatous heart disease. Angiology 36(8):485\u2013492. https:\/\/doi.org\/10.1177\/000331978503600801","journal-title":"Angiology"},{"issue":"9","key":"70_CR5","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1007\/s00044-011-9755-5","volume":"21","author":"M Ahmad","year":"2012","unstructured":"Ahmad M, Rizvi SUF, c HL, Ahmad S, Parvez M, Suliman R (2012) Antioxidant and antimicrobial studies of novel N\u2032-(substituted-2-chloroquinolin-3-yl) methylidene-4-hydroxy-2 H-1, 2-benzothiazine-3-carbohydrazides 1, 1-dioxides. Med Chem Res 21(9):2340\u20132348. https:\/\/doi.org\/10.1007\/s00044-011-9755-5","journal-title":"Med Chem Res"},{"key":"70_CR6","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.bioorg.2018.04.012","volume":"80","author":"S Ahmad","year":"2018","unstructured":"Ahmad S, Zaib S, Jalil S, Shafiq M, Ahmad M, Sultan S, Iqbal M, Iqbal J (2018) Synthesis, characterization, monoamine oxidase inhibition, molecular docking and dynamic simulations of novel 2, 1-benzothiazine-2, 2-dioxide derivatives. Bioorg Chem 80:498\u2013510. https:\/\/doi.org\/10.1016\/j.bioorg.2018.04.012","journal-title":"Bioorg Chem"},{"issue":"4","key":"70_CR7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3329\/bjp.v9i4.20412","volume":"9","author":"B Ahmed","year":"2014","unstructured":"Ahmed B, Ashfaq UA, ul Qamar MT, Ahmad M (2014) Anticancer potential of phytochemicals against breast cancer: molecular docking and simulation approach. Bangladesh J Pharmacol 9(4):545\u2013550","journal-title":"Bangladesh J Pharmacol"},{"issue":"2","key":"70_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.12944\/CRNFSJ.10.2.13","volume":"10","author":"RW Aisya","year":"2022","unstructured":"Aisya RW, Hs K, Widyastiti NS, Afifah DN (2022) The effectiveness of Aloe-based drink in reducing glycated albumin and insulin resistance of metabolic syndrome: a randomized clinical trial. Curr Res Nutr Food Sci Jour 10(2):583\u2013592. https:\/\/doi.org\/10.12944\/CRNFSJ.10.2.13","journal-title":"Curr Res Nutr Food Sci Jour"},{"issue":"5","key":"70_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2024.101906","volume":"28","author":"S Akram","year":"2024","unstructured":"Akram S, Aslam S, Rasool N, Ahmad M, Al-Hussain SA, Zaki ME (2024) Furo[3,2-b] pyridine: chemical synthesis, transformations and biological applications. J Saudi Chem Soc 28(5):101906. https:\/\/doi.org\/10.1016\/j.jscs.2024.101906","journal-title":"J Saudi Chem Soc"},{"issue":"4","key":"70_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2023.102589","volume":"35","author":"NS Al-Sowayan","year":"2023","unstructured":"Al-Sowayan NS, AL-Sallali RM (2023) The effect of aloin in blood glucose and antioxidants in male albino rats with streptozoticin-induced diabetic. J of King Saud Univ-Sci 35(4):102589. https:\/\/doi.org\/10.1016\/j.jksus.2023.102589","journal-title":"J of King Saud Univ-Sci"},{"key":"70_CR11","doi-asserted-by":"publisher","unstructured":"Association AD\u00a0(2020) 15. Diabetes care in the hospital: standards of medical care in diabetes\u20142020. Diabetes Care 43(Supplement_1):S193\u2013S202. https:\/\/doi.org\/10.2337\/dc21-s015","DOI":"10.2337\/dc21-s015"},{"key":"70_CR12","doi-asserted-by":"publisher","unstructured":"Amin R, Darwin R, Hussain MI, Borah ML (2024) Foot ulcer: an effect of Aloe vera. In: Pharmaceutical Sciences: Research and Innovation 3:69\u201373. https:\/\/doi.org\/10.58532\/PSRICH10","DOI":"10.58532\/PSRICH10"},{"key":"70_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115734","volume":"168","author":"SA Antar","year":"2023","unstructured":"Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, Rooh EJ, Al-Karmalawy AA (2023) Diabetes mellitus: classification, mediators, and complications; a gate to identify potential targets for the development of new effective treatments. Biomed Pharmacother 168:115734. https:\/\/doi.org\/10.1016\/j.biopha.2023.115734","journal-title":"Biomed Pharmacother"},{"key":"70_CR14","doi-asserted-by":"publisher","unstructured":"Antoine AR, Farid AA, Aline1 Z, Sanyour J (2023) Aloe vera induce acute liver injury and chronic liver disease: case report.\u00a0World J Case Rep Clin Imag 2(1):1\u20137. https:\/\/doi.org\/10.51521\/WJCRCI.2023.2104","DOI":"10.51521\/WJCRCI.2023.2104"},{"key":"70_CR15","doi-asserted-by":"publisher","unstructured":"Araya-Quintanilla F, Guti\u00e9rrez-Espinoza H, Cuyul-V\u00e1squez I, Pavez (2021) Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: An overview of systematic reviews.\u00a0Diabetes Metab Syndr\u00a015(6):102292. https:\/\/doi.org\/10.1016\/j.dsx.2021.102292","DOI":"10.1016\/j.dsx.2021.102292"},{"key":"70_CR16","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1007\/s00044-013-0879-7","volume":"23","author":"S Aslam","year":"2014","unstructured":"Aslam S, Ahmad M, Athar MM, Ashfaq UA, Gardiner JM, Montero C, Detorio M, Parvez M, Schinazi RF (2014) Synthesis, molecular docking and antiviral screening of novel N\u2032-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo [e] pyrazolo [4,3-c][1,2] thiazin-1 (4H)-yl) acetohydrazides. Med Chem Res 23:2930\u20132946. https:\/\/doi.org\/10.1007\/s00044-013-0879-7","journal-title":"Med Chem Res"},{"key":"70_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114445","volume":"280","author":"SN Babu","year":"2021","unstructured":"Babu SN, Govindarajan S, Noor A (2021a) Aloe vera and its two bioactive constituents in alleviation of diabetes\u2013proteomic & mechanistic insights. J Ethnopharmacol 280:114445. https:\/\/doi.org\/10.1016\/j.jep.2021.114445","journal-title":"J Ethnopharmacol"},{"key":"70_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113949","volume":"272","author":"SN Babu","year":"2021","unstructured":"Babu SN, Govindarajan S, Vijayalakshmi MA, Noor A (2021b) Role of zonulin and GLP-1\/DPP-IV in alleviation of diabetes mellitus by peptide\/polypeptide fraction of Aloe vera in streptozotocin-induced diabetic wistar rats. J Ethnopharmacol 272:113949. https:\/\/doi.org\/10.1016\/j.jep.2021.113949","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"70_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.33590\/emjdiabet\/10313616","volume":"7","author":"Z Berberoglu","year":"2019","unstructured":"Berberoglu Z (2019) Pathophysiology of gestational diabetes mellitus. Diabetes 7(1):97\u2013106. https:\/\/doi.org\/10.33590\/emjdiabet\/10313616","journal-title":"Diabetes"},{"key":"70_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/9781118976074","volume-title":"Handbook of diabetes","author":"R Bilous","year":"2021","unstructured":"Bilous R, Donnelly R, Idris I (2021) Handbook of diabetes. Wiley"},{"issue":"3","key":"70_CR21","doi-asserted-by":"publisher","first-page":"536","DOI":"10.31965\/infokes.Vol21Iss3.1361","volume":"21","author":"I Budiastutik","year":"2023","unstructured":"Budiastutik I, Ningsih NS (2023) Aloe vera: potential to reduce fasting blood sugar levels in prediabetes. J Info Kes 21(3):536\u2013543. https:\/\/doi.org\/10.31965\/infokes.Vol21Iss3.1361","journal-title":"J Info Kes"},{"issue":"4","key":"70_CR22","doi-asserted-by":"publisher","first-page":"737","DOI":"10.56499\/jppres22.1378_10.4.737","volume":"10","author":"I Budiastutik","year":"2022","unstructured":"Budiastutik I, Subagio HW, Kartasurya MI, Widjanarko B, Kartini A, Soegiyanto B, Suhartono S (2022) The effect of Aloe vera on fasting blood glucose levels in pre-diabetes and type 2 diabetes mellitus: a systematic review and meta-analysis. J Pharm Pharmacogn Res 10(4):737\u2013747. https:\/\/doi.org\/10.56499\/jppres22.1378_10.4.737","journal-title":"J Pharm Pharmacogn Res"},{"issue":"3","key":"70_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/s0944-7113(96)80061-4","volume":"3","author":"N Bunyapraphatsara","year":"1996","unstructured":"Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O (1996) Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 3(3):245\u2013248. https:\/\/doi.org\/10.1016\/s0944-7113(96)80061-4","journal-title":"Phytomedicine"},{"issue":"11","key":"70_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113162","volume":"9","author":"A But","year":"2014","unstructured":"But A, Wang H, M\u00e4nnist\u00f6 S, Pukkala E, Haukka J (2014) Assessing the effect of treatment duration on the association between anti-diabetic medication and cancer risk. PLoS ONE 9(11):e113162. https:\/\/doi.org\/10.1371\/journal.pone.0113162","journal-title":"PLoS ONE"},{"issue":"7","key":"70_CR25","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.47191\/ijcsrr\/V6-i7-06","volume":"6","author":"SK Cahyaningtias","year":"2023","unstructured":"Cahyaningtias SK, Sanjaya IGM (2023) Potential of Aloin B compound and its derivatives as type-2 antidiabetic. Int J Curr Sci Res Rev 6(7):3889\u20133899. https:\/\/doi.org\/10.47191\/ijcsrr\/V6-i7-06","journal-title":"Int J Curr Sci Res Rev"},{"issue":"13","key":"70_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/foods13132155","volume":"13","author":"A Catalano","year":"2024","unstructured":"Catalano A, Ceramella J, Iacopetta D, Marra M, Conforti F, Lupi FR, Gabriele D, Borges F, Sinicropi MS (2024) Aloe vera\u2015an extensive review focused on recent studies. Foods 13(13):2155. https:\/\/doi.org\/10.3390\/foods13132155","journal-title":"Foods"},{"key":"70_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112152","volume":"222","author":"A Ceriello","year":"2025","unstructured":"Ceriello A, Colagiuri S (2025) IDF global clinical practice recommendations for managing type 2 diabetes\u20132025. Diabetes Res Clin Pract 222:112152. https:\/\/doi.org\/10.1016\/j.diabres.2025.112152","journal-title":"Diabetes Res Clin Pract"},{"key":"70_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102601","volume":"64","author":"T Chakraborty","year":"2021","unstructured":"Chakraborty T, Gupta S, Nair A, Chauhan S, Saini V (2021) Wound healing potential of insulin-loaded nanoemulsion with Aloe vera gel in diabetic rats. J Drug Deliv Sci Technol 64:102601. https:\/\/doi.org\/10.1016\/j.jddst.2021.102601","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"70_CR29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jtcme.2017.08.012","volume":"8","author":"H Choudhury","year":"2018","unstructured":"Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, Ashraf NK, Kit SW, Yee TS, Pichika MR, Gorain B, Kesharwani P (2018) An update on natural compounds in the remedy of diabetes mellitus: a systematic review. J Tradit Complement Med 8(3):361\u2013376. https:\/\/doi.org\/10.1016\/j.jtcme.2017.08.012","journal-title":"J Tradit Complement Med"},{"key":"70_CR30","unstructured":"Collins L, Costello RA (2024) Glucagon-like peptide-1 receptor agonists In: StatPearls Publishing. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551568\/"},{"issue":"3","key":"70_CR31","first-page":"396","volume":"33","author":"CE Collins","year":"1935","unstructured":"Collins CE, Collins C (1935) Roentgen dermatitis treated with fresh whole leaf of Aloe vera. AJR Am J Roentgenol 33(3):396\u2013397","journal-title":"AJR Am J Roentgenol"},{"key":"70_CR32","doi-asserted-by":"publisher","DOI":"10.54112\/bcsrj.v2020i1.4","author":"P Danish","year":"2020","unstructured":"Danish P, Ali Q, Hafeez MM, Malik A (2020) Antifungal and antibacterial activity of Aloe vera plant extract. Biol Clin Sci Res J. https:\/\/doi.org\/10.54112\/bcsrj.v2020i1.4","journal-title":"Biol Clin Sci Res J"},{"issue":"9","key":"70_CR33","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.1021\/acs.molpharmaceut.1c00248","volume":"18","author":"B Darvishi","year":"2021","unstructured":"Darvishi B, Dinarvand R, Mohammadpour H, Kamarul T, Sharifi AM (2021) Dual l-carnosine\/Aloe vera nanophytosomes with synergistically enhanced protective effects against methylglyoxal-induced angiogenesis impairment. Mol Pharm 18(9):3302\u20133325. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.1c00248","journal-title":"Mol Pharm"},{"issue":"3","key":"70_CR34","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1046\/j.1464-5491.1999.00023.x","volume":"16","author":"C Day","year":"1999","unstructured":"Day C (1999) Thiazolidinediones: a new class of antidiabetic drugs. Diabet Med 16(3):179\u2013192. https:\/\/doi.org\/10.1046\/j.1464-5491.1999.00023.x","journal-title":"Diabet Med"},{"issue":"2","key":"70_CR35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.37349\/emed.2022.00084","volume":"3","author":"K Delladetsima","year":"2022","unstructured":"Delladetsima K, Manesis E, Tiniakos D, Sakellariou S (2022) Complex liver injury induced by combined Aloe vera and vitamin a oral supplements, as assessed by histology and the updated RUCAM. EM 3(2):181\u2013187. https:\/\/doi.org\/10.37349\/emed.2022.00084","journal-title":"EM"},{"key":"70_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113921","volume":"272","author":"N Deora","year":"2021","unstructured":"Deora N, Sunitha MM, Satyavani M, Harishankar N, Vijayalakshmi MA, Venkataraman K, Venkateshan V (2021) Alleviation of diabetes mellitus through the restoration of \u03b2-cell function and lipid metabolism by Aloe vera (L.) burm. f. extract in obesogenic WNIN\/GR-Ob rats. J Ethnopharmacol 272:113921. https:\/\/doi.org\/10.1016\/j.jep.2021.113921","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"70_CR37","doi-asserted-by":"publisher","first-page":"6847","DOI":"10.55522\/jmpas.V13I6.6798","volume":"13","author":"S Desai","year":"2024","unstructured":"Desai S, Thakkar V, Gandhi T (2024) The combined effect of medicinal plant extract and sulfonylurea agent: a preliminary study to evaluate anti-diabetic potential in experimental animals. J Med Pharm and Allied Sci 13(6):6847\u20136854. https:\/\/doi.org\/10.55522\/jmpas.V13I6.6798","journal-title":"J Med Pharm and Allied Sci"},{"issue":"3","key":"70_CR38","first-page":"103","volume":"2","author":"A Devaraj","year":"2011","unstructured":"Devaraj A, Karpagam T (2011) Evaluation of anti-inflammatory activity and analgesic effect of Aloe vera leaf extract in rats. Int Res J Pharm 2(3):103\u2013110","journal-title":"Int Res J Pharm"},{"issue":"3","key":"70_CR39","doi-asserted-by":"publisher","first-page":"222","DOI":"10.33084\/bjop.v6i3.5351","volume":"6","author":"NI Dibal","year":"2023","unstructured":"Dibal NI, Goni ZM, Attah MOO, Imam U, Abdullahi M, Bashir M, Adam U, Aisami F, Shuwa M, Manye SJ, Gadzama MN, Chiroma MS, Ishaya HB (2023) Aloe vera gel ameliorates fat-rich and high fructose (FRHF) diet-induced pancreatic and splenic damage in mice. Borneo J Pharm 6(3):222\u2013228. https:\/\/doi.org\/10.33084\/bjop.v6i3.5351","journal-title":"Borneo J Pharm"},{"key":"70_CR40","doi-asserted-by":"publisher","unstructured":"Dibal NI, Buba F, Laminu HH, Zirahei JV, Musa H, Bitrus S, Adam HI, Mara, Dawa DC, Solomon D, Abdullahi B, Mbaya HJ, Garba S, Lamba AM, Manye SJ, Ishaku B, Attah MOO, Chiroma SM (2024) The protective role of aqueous and methanol extracts of Aloe vera on ethanol-induced kidney and brain injury in mice. Sahel J Vet Sci 21(4):14\u201319. https:\/\/doi.org\/10.54058\/tsqn7b43","DOI":"10.54058\/tsqn7b43"},{"key":"70_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.meomic.2022.100013","volume":"3","author":"L dos Santos","year":"2021","unstructured":"dos Santos L, Arita LS, Perez JD, Carvalho VM, Tashima AK, Cunha TS, Casarini DE, Arita DY (2021) Exploring the beneficial effects of Aloe vera on the kidneys of diabetic rats at the protein level. Med Omics 3:100013. https:\/\/doi.org\/10.1016\/j.meomic.2022.100013","journal-title":"Med Omics"},{"issue":"17","key":"70_CR42","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.2174\/0929867324666170426142826","volume":"24","author":"SS Eckstein","year":"2017","unstructured":"Eckstein SS, Weigert C, Lehmann R (2017) Divergent roles of IRS (insulin receptor substrate) 1 and 2 in liver and skeletal muscle. Curr Med Chem 24(17):1827\u20131852. https:\/\/doi.org\/10.2174\/0929867324666170426142826","journal-title":"Curr Med Chem"},{"issue":"2","key":"70_CR43","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.jep.2014.05.055","volume":"155","author":"UF Ezuruike","year":"2014","unstructured":"Ezuruike UF, Prieto JM (2014) The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations. J Ethnopharmacol 155(2):857\u2013924. https:\/\/doi.org\/10.1016\/j.jep.2014.05.055","journal-title":"J Ethnopharmacol"},{"issue":"43","key":"70_CR44","first-page":"19","volume":"11","author":"HH Fallah","year":"2012","unstructured":"Fallah HH, Kianbakht S, Hajiaghaee R, Afkhami AM, Bonakdaran A, Hashem DF (2012) Aloe vera leaf gel in treatment of advanced type 2 diabetes mellitus needing insulin therapy: a randomized double-blind placebo-controlled clinical trial. J Med Plants 11(43):19\u201327","journal-title":"J Med Plants"},{"key":"70_CR45","doi-asserted-by":"publisher","unstructured":"Fandizal M,\u00a0Astuti Y, Riani N, Ramadhan AR, Ariastika WA (2021) Effect of Aloe vera drink with cinnamon on blood sugar reduction in families with type II diabetes mellitus in east jakarta. JIIKI 11(04):214\u2013218. https:\/\/doi.org\/10.33221\/jiiki.v11i04.1748","DOI":"10.33221\/jiiki.v11i04.1748"},{"issue":"1","key":"70_CR46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.31580\/pjmls.v7i1.3010","volume":"7","author":"Z Fatima","year":"2024","unstructured":"Fatima Z, Fatima N, Aziz O, Javed W, Shoaib M, Khaliq HMH, Yasin A (2024) In vivo exploration of Aloe vera: assessing anti-hyperglycemic effects in rats models for therapeutic insights. PJMLS 7(1):17\u201324. https:\/\/doi.org\/10.31580\/pjmls.v7i1.3010","journal-title":"PJMLS"},{"issue":"3","key":"70_CR47","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.19045\/bspab.2020.90226","volume":"9","author":"TA Fazlani","year":"2020","unstructured":"Fazlani TA, Baloch JA, Soomro SA, Soomro J, Kasi AK, Shahwani PM, Memon M, Fazilani SA, Rahimoon M, Dahri TH (2020) Effect of Aloe vera and metformin on diabetic albino rats. PAB 9(3):2122\u20132127. https:\/\/doi.org\/10.19045\/bspab.2020.90226","journal-title":"PAB"},{"issue":"1","key":"70_CR48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12933-015-0294-0","volume":"14","author":"EZ Fisman","year":"2015","unstructured":"Fisman EZ, Tenenbaum A (2015) Antidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes. Cardiovasc Diabetol 14(1):29. https:\/\/doi.org\/10.1186\/s12933-015-0294-0","journal-title":"Cardiovasc Diabetol"},{"issue":"17","key":"70_CR49","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.3390\/ijms21176275","volume":"21","author":"U Galicia-Garcia","year":"2020","unstructured":"Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Mart\u00edn C (2020) Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci 21(17):6275. https:\/\/doi.org\/10.3390\/ijms21176275","journal-title":"Int J Mol Sci"},{"issue":"1","key":"70_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.34172\/ijbsm.2023.01","volume":"8","author":"HR Ghaffari","year":"2023","unstructured":"Ghaffari HR, Bagheri GR, Fouladi B, Barmaki B, Tabrizi MA, Poursamimi M, Poursamimi J (2023) The protective effects of Aloe vera gel extract on the sexual complications caused by diabetes in male rats. Int J Basic Sci Med 8(1):1\u201310. https:\/\/doi.org\/10.34172\/ijbsm.2023.01","journal-title":"Int J Basic Sci Med"},{"key":"70_CR51","doi-asserted-by":"publisher","unstructured":"Gharaboghaz MNZ, Farahpour MR, Saghaie S (2020) Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomed Pharmacother 127:110189. https:\/\/doi.org\/10.1016\/j.biopha.2020.110189","DOI":"10.1016\/j.biopha.2020.110189"},{"key":"70_CR52","doi-asserted-by":"publisher","unstructured":"Ghosh I, Banerjee S, Dutta S, Maji HS, Mondal A (2025) Exploring the anti-diabetic potential of Aloe vera: isolation and characterization of bioactive compounds. Nat Prod Res 1\u20137. https:\/\/doi.org\/10.1080\/14786419.2025.2451775","DOI":"10.1080\/14786419.2025.2451775"},{"issue":"9","key":"70_CR53","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107(9):1058\u20131070. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.223545","journal-title":"Circ Res"},{"issue":"2","key":"70_CR54","doi-asserted-by":"publisher","first-page":"86","DOI":"10.25303\/1802rjbt86096","volume":"18","author":"S Govindarajan","year":"2023","unstructured":"Govindarajan S, Ayesha N (2023) Isolated fractions of Aloe vera carbohydrate ameliorate streptozotocin-induced pancreatic \u03b2-cell damage and bidirectionally regulated AMPK activity. Res J Biotechnol 18(2):86\u201396. https:\/\/doi.org\/10.25303\/1802rjbt86096","journal-title":"Res J Biotechnol"},{"key":"70_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114556","volume":"281","author":"S Govindarajan","year":"2021","unstructured":"Govindarajan S, Babu SN, Vijayalakshmi MA, Manohar P, Noor A (2021) Aloe vera carbohydrates regulate glucose metabolism through improved glycogen synthesis and downregulation of hepatic gluconeogenesis in diabetic rats. J Ethnopharmacol 281:114556. https:\/\/doi.org\/10.1016\/j.jep.2021.114556","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"70_CR56","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.2337\/dc06-2499","volume":"30","author":"RW Grant","year":"2007","unstructured":"Grant RW, Wexler DJ, Watson AJ, Lester WT, Cagliero E, Campbell EG, Nathan DM (2007) How doctors choose medications to treat type 2 diabetes: a national survey of specialists and academic generalists. Diabetes Care 30(6):1448\u20131453. https:\/\/doi.org\/10.2337\/dc06-2499","journal-title":"Diabetes Care"},{"issue":"5","key":"70_CR57","doi-asserted-by":"publisher","first-page":"936","DOI":"10.5114\/aoms.2013.34991","volume":"9","author":"R Guardado-Mendoza","year":"2013","unstructured":"Guardado-Mendoza R, Prioletta A, Jim\u00e9nez-Ceja LM, Sosale A, Folli F (2013) State of the art paper the role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus. Arch Med Sci 9(5):936\u2013943. https:\/\/doi.org\/10.5114\/aoms.2013.34991","journal-title":"Arch Med Sci"},{"issue":"2","key":"70_CR58","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s43450-022-00231-3","volume":"32","author":"F Haghani","year":"2022","unstructured":"Haghani F, Arabnezhad MR, Mohammadi S, Ghaffarian-Bahraman A (2022) Aloe vera and streptozotocin-induced diabetes mellitus. Rev Bras Farmacogn 32(2):174\u2013187. https:\/\/doi.org\/10.1007\/s43450-022-00231-3","journal-title":"Rev Bras Farmacogn"},{"issue":"63","key":"70_CR59","doi-asserted-by":"publisher","first-page":"124","DOI":"10.24996\/ijs.2022.63.1.14","volume":"1","author":"ZYM Hasan","year":"2022","unstructured":"Hasan ZYM, Abdullah JM (2022) Effects of gel extract from Aloe vera cultivated in Iraq on blood glucose level and lipid profile in induced diabetic mice. Iraqi J Sci 1(63):124\u2013130. https:\/\/doi.org\/10.24996\/ijs.2022.63.1.14","journal-title":"Iraqi J Sci"},{"issue":"1","key":"70_CR60","first-page":"1","volume":"44","author":"D Hekmatpou","year":"2019","unstructured":"Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A (2019) The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review. Iran J Med Sci 44(1):1\u20139","journal-title":"Iran J Med Sci"},{"issue":"1","key":"70_CR61","doi-asserted-by":"publisher","first-page":"258","DOI":"10.2337\/dci20-0053","volume":"44","author":"F Hill-Briggs","year":"2020","unstructured":"Hill-Briggs F, Adler NE, Berkowitz SA, Chin MH, Gary-Webb TL, Navas-Acien A, Thornton PM, Haire-Joshu D (2020) Social determinants of health and diabetes: a scientific review. Diabetes Care 44(1):258. https:\/\/doi.org\/10.2337\/dci20-0053","journal-title":"Diabetes Care"},{"key":"70_CR62","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3477","volume":"354","author":"J Hippisley-Cox","year":"2016","unstructured":"Hippisley-Cox J, Coupland C (2016) Diabetes treatments and risk of heart failure, cardiovascular disease, and all cause mortality: cohort study in primary care. BMJ 354:i3477. https:\/\/doi.org\/10.1136\/bmj.i3477","journal-title":"BMJ"},{"issue":"1","key":"70_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/polysaccharides6020036","volume":"17","author":"MA Hosseini","year":"2024","unstructured":"Hosseini MA, Rostam Khani M, Abdi S, Abdi S, Sharifi N (2024) Comparison of Aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: a clinical trial. BMC Res Notes 17(1):25. https:\/\/doi.org\/10.3390\/polysaccharides6020036","journal-title":"BMC Res Notes"},{"issue":"3","key":"70_CR64","doi-asserted-by":"publisher","first-page":"360","DOI":"10.22271\/oral.2021.v7.i3f.1322","volume":"7","author":"AM Hutapea","year":"2021","unstructured":"Hutapea AM, Susanto C (2021) Hypoglycemic potential of Aloe vera in diabetes mellitus induced by diabetogenic substances and high fat diet: a systematic meta-analysis review. Int J Appl Dent Sci 7(3):360\u2013368. https:\/\/doi.org\/10.22271\/oral.2021.v7.i3f.1322","journal-title":"Int J Appl Dent Sci"},{"key":"70_CR65","first-page":"847","volume":"33","author":"F Ibraheem","year":"2020","unstructured":"Ibraheem F, Ahmad M, Ashfaq UA, Aslam S, Ali Khan Z, Sultan S (2020) Synthesis, molecular docking and anti-diabetic studies of novel benzimidazole-pyrazoline hybrid molecules. Pak J Pharm Sci 33:847\u2013854","journal-title":"Pak J Pharm Sci"},{"issue":"11","key":"70_CR66","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/21450.8890","volume":"10","author":"S Jain","year":"2016","unstructured":"Jain S, Rathod N, Sur J, Laheji A, Gupta N, Agrawal P, Prasad S (2016) Antibacterial effect of Aloe vera gel against oral pathogens: an in vitro study. J Clin Diagn Res 10(11):ZC41. https:\/\/doi.org\/10.7860\/JCDR\/2016\/21450.8890","journal-title":"J Clin Diagn Res"},{"key":"70_CR67","doi-asserted-by":"publisher","unstructured":"Javaid S, Waheed A (2020a) Antidiabetic effects of Aloe vera whole leaf extract and sitagliptin in streptozotocin-induced diabetic rats. JRMC. https:\/\/doi.org\/10.37939\/jrmc.v24i4.1469","DOI":"10.37939\/jrmc.v24i4.1469"},{"key":"70_CR68","unstructured":"Javaid S, Waheed A (2020b) Hypoglycemic and hypotriglyceridemic effects of Aloe vera whole leaf and sitagliptin in diabetic rats. Int J Pathol 18(2):48\u201352. https:\/\/www.jpathology.com\/index.php\/OJS\/article\/view\/562"},{"key":"70_CR69","doi-asserted-by":"publisher","unstructured":"Javaid S, Waheed A (2024) Anti-obesity effects of Aloe vera whole leaf and sitagliptin in diabetic rats. APMC 14(4):295\u2013298. https:\/\/doi.org\/10.29054\/apmc\/2020.1023","DOI":"10.29054\/apmc\/2020.1023"},{"issue":"1","key":"70_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.16","volume":"3","author":"A Katsarou","year":"2017","unstructured":"Katsarou A, Gudbj\u00f6rnsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson BJ, Jacobsen LM, Schatz DA, Lernmark \u00c5 (2017) Type 1 diabetes mellitus. Nat Rev Dis Primers 3(1):1\u201317. https:\/\/doi.org\/10.1038\/nrdp.2017.16","journal-title":"Nat Rev Dis Primers"},{"issue":"3\u20134","key":"70_CR71","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1024\/0300-9831\/a000797","volume":"94","author":"S Kaur","year":"2024","unstructured":"Kaur S, Bains K (2024) Aloe Barbadensis Miller (Aloe Vera). Int J Vitam Nutr Res 94(3\u20134):308\u2013321. https:\/\/doi.org\/10.1024\/0300-9831\/a000797","journal-title":"Int J Vitam Nutr Res"},{"issue":"4","key":"70_CR72","doi-asserted-by":"publisher","first-page":"310","DOI":"10.2991\/efood.k.200824.001","volume":"1","author":"MI Kazeem","year":"2020","unstructured":"Kazeem MI, Bankole HA, Oladokun TI, Bello AO, Maliki MA (2020) Citrus aurantifolia (Christm.) Swingle (lime) fruit extract inhibits the activities of polyol pathway enzymes. eFood 1(4):310\u2013315. https:\/\/doi.org\/10.2991\/efood.k.200824.001","journal-title":"eFood"},{"key":"70_CR73","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1007\/s00044-015-1411-z","volume":"24","author":"Z Khalid","year":"2015","unstructured":"Khalid Z, Aslam S, Ahmad M, Munawar MA, Montero C, Detorio M, Parvez M, Schinazi RF (2015) Anti-HIV activity of new pyrazolobenzothiazine 5, 5-dioxide-based acetohydrazides. Med Chem Res 24:3671\u20133680. https:\/\/doi.org\/10.1007\/s00044-015-1411-z","journal-title":"Med Chem Res"},{"key":"70_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.111977","volume":"123","author":"S Kud\u0142acik-Kramarczyk","year":"2021","unstructured":"Kud\u0142acik-Kramarczyk S, Drabczyk A, G\u0142\u0105b M, Alves-Lima D, Lin H, Douglas T, Kuciel S, Zagorska A, Tyliszczak B (2021) Investigations on the impact of the introduction of the Aloe vera into the hydrogel matrix on cytotoxic and hydrophilic properties of these systems considered as potential wound dressings. Mater Sci Eng 123:111977. https:\/\/doi.org\/10.1016\/j.msec.2021.111977","journal-title":"Mater Sci Eng"},{"key":"70_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152996","volume":"60","author":"R Kumar","year":"2019","unstructured":"Kumar R, Singh AK, Gupta A, Bishayee A, Pandey AK (2019) Therapeutic potential of Aloe vera\u2014a miracle gift of nature. Phytomedicine 60:152996. https:\/\/doi.org\/10.1016\/j.phymed.2019.152996","journal-title":"Phytomedicine"},{"issue":"11","key":"70_CR76","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1345\/aph.1A061","volume":"35","author":"TL Levien","year":"2001","unstructured":"Levien TL, Baker DE, Campbell RK, White JJR (2001) Nateglinide therapy for type 2 diabetes mellitus. Ann Pharmacother 35(11):1426\u20131434. https:\/\/doi.org\/10.1345\/aph.1A061","journal-title":"Ann Pharmacother"},{"issue":"1","key":"70_CR77","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142239","volume":"131","author":"GF Lewis","year":"2021","unstructured":"Lewis GF, Brubaker PL (2021) The discovery of insulin revisited: lessons for the modern era. J Clin Invest 131(1):e142239. https:\/\/doi.org\/10.1172\/JCI142239","journal-title":"J Clin Invest"},{"issue":"1","key":"70_CR78","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2421624","volume":"2022","author":"L Lu","year":"2022","unstructured":"Lu L, Li Y (2022) Aloe\u2010emodin ameliorates diabetic nephropathy by targeting interferon regulatory factor 4. eCAM 2022(1):2421624. https:\/\/doi.org\/10.1155\/2022\/2421624","journal-title":"eCAM"},{"key":"70_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hermed.2018.01.002","volume":"12","author":"AA Maan","year":"2018","unstructured":"Maan AA, Nazir A, Khan MKI, Ahmad T, Zia R, Murid M, Abrar M (2018) The therapeutic properties and applications of Aloe vera: a review. J Herb Med 12:1\u201310. https:\/\/doi.org\/10.1016\/j.hermed.2018.01.002","journal-title":"J Herb Med"},{"key":"70_CR80","unstructured":"Madhavan SA, Mahadevi M, Vinotha P, Uma V (2020) Anti-hyperglycemia activity by ethanolic extract Aloe vera of against mouse 3T3-L1 adipocyte cell line. Science 1(3):58\u201366"},{"issue":"2","key":"70_CR81","doi-asserted-by":"publisher","first-page":"577","DOI":"10.4067\/S0717-95022021000200577","volume":"39","author":"MK Mahabady","year":"2021","unstructured":"Mahabady MK, Tapebur MB, Mazaheri Y, Tabandeh MR, Tabatabaei SRF (2021) Effect of Aloe vera on the expression of nerve factors, p75 and TrkA receptors in the hippocampus of diabetic rats. Int J Morphol 39(2):577\u2013586. https:\/\/doi.org\/10.4067\/S0717-95022021000200577","journal-title":"Int J Morphol"},{"key":"70_CR82","doi-asserted-by":"publisher","unstructured":"Magno LD, Di Pastena F, Bordone R, Coni S, Canettieri G (2022) The mechanism of action of biguanides: new answers to a complex question. Cancers 14(13):3220. https:\/\/doi.org\/10.3390\/cancers14133220","DOI":"10.3390\/cancers14133220"},{"issue":"1","key":"70_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.22034\/JEOCT.2021.281858.1001","volume":"1","author":"SR Malayeri","year":"2021","unstructured":"Malayeri SR, Rahimi H, Mousavi Sadati SK, Behdari R (2021) Brain-derived neurotrophic factor (BDNF) variation to aerobic exercise and Aloe vera intake in women with type 2 diabetes. J Exerc Organ Cross Talk 1(1):1\u20137. https:\/\/doi.org\/10.22034\/JEOCT.2021.281858.1001","journal-title":"J Exerc Organ Cross Talk"},{"issue":"39","key":"70_CR84","doi-asserted-by":"publisher","first-page":"59727","DOI":"10.1007\/s11356-022-20100-9","volume":"29","author":"D Massoud","year":"2022","unstructured":"Massoud D, Fouda MM, Sarhan M, Salama SG, Khalifa HS (2022) Topical application of aloe gel and\/or olive oil combination promotes the wound healing properties of streptozotocin-induced diabetic rats. Environ Sci Pollut Res 29(39):59727\u201359735. https:\/\/doi.org\/10.1007\/s11356-022-20100-9","journal-title":"Environ Sci Pollut Res"},{"issue":"2","key":"70_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/polysaccharides6020036","volume":"6","author":"CE Matei","year":"2025","unstructured":"Matei CE, Visan AI, Cristescu R (2025) Aloe vera polysaccharides as therapeutic agents: benefits versus side effects in biomedical applications. Polysaccharides 6(2):36. https:\/\/doi.org\/10.3390\/polysaccharides6020036","journal-title":"Polysaccharides"},{"issue":"1","key":"70_CR86","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-10-23","volume":"10","author":"A Mazur","year":"2011","unstructured":"Mazur A (2011) Why were\" starvation diets\" promoted for diabetes in the pre-insulin period? Nutr J 10(1):23","journal-title":"Nutr J"},{"issue":"22","key":"70_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/polym13223958","volume":"13","author":"KZ Meza-Valle","year":"2021","unstructured":"Meza-Valle KZ, Saucedo-Acu\u00f1a RA, Tovar-Carrillo KL, Cuevas-Gonz\u00e1lez JC, Zaragoza-Contreras EA, Melgoza-Lozano J (2021) Characterization and topical study of Aloe vera hydrogel on wound-healing process. Polymers 13(22):3958. https:\/\/doi.org\/10.3390\/polym13223958","journal-title":"Polymers"},{"key":"70_CR88","doi-asserted-by":"publisher","first-page":"124","DOI":"10.4103\/epj.epj_59_19","volume":"2","author":"P Mondal","year":"2020","unstructured":"Mondal P, Venu K, Thimmaraju MK, Chanbasha S (2020) Herb\u2013drug interaction study between and glimepiride in normal and diabetic rats. Egypt Pharma J 2:124\u2013135. https:\/\/doi.org\/10.4103\/epj.epj_59_19","journal-title":"Egypt Pharma J"},{"issue":"1","key":"70_CR89","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6371201","volume":"2020","author":"A Mu\u00f1iz-Ramirez","year":"2020","unstructured":"Mu\u00f1iz-Ramirez A, Perez RM, Garcia E, Garcia FE (2020) Antidiabetic activity of Aloe vera leaves. Evid Based Complement Alternat Med 2020(1):6371201. https:\/\/doi.org\/10.1155\/2020\/6371201","journal-title":"Evid Based Complement Alternat Med"},{"issue":"34","key":"70_CR90","doi-asserted-by":"publisher","first-page":"8142","DOI":"10.1039\/D3TB01151H","volume":"11","author":"K Naik","year":"2023","unstructured":"Naik K, Singh P, Yadav M, Srivastava SK, Tripathi S, Ranjan R, Dhar P, Verma AK, Chaudhary S, Parmar AS (2023) 3D printable, injectable amyloid-based composite hydrogel of bovine serum albumin and Aloe vera for rapid diabetic wound healing. J Mater Chem 11(34):8142\u20138158. https:\/\/doi.org\/10.1039\/D3TB01151H","journal-title":"J Mater Chem"},{"issue":"1","key":"70_CR91","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-021-00296-2","volume":"7","author":"F Nalimu","year":"2021","unstructured":"Nalimu F, Oloro J, Kahwa I, Ogwang PE (2021) Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future J Pharm Sci 7(1):145. https:\/\/doi.org\/10.1186\/s43094-021-00296-2","journal-title":"Future J Pharm Sci"},{"issue":"1","key":"70_CR92","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03470-4","volume":"22","author":"F Nalimu","year":"2022","unstructured":"Nalimu F, Oloro J, Peter EL, Ogwang PE (2022) Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats. BMC Complement Med Ther 22(1):16. https:\/\/doi.org\/10.1186\/s12906-021-03470-4","journal-title":"BMC Complement Med Ther"},{"issue":"1","key":"70_CR93","doi-asserted-by":"publisher","DOI":"10.1186\/2191-2858-3-5","volume":"3","author":"F Nejatzadeh-Barandozi","year":"2013","unstructured":"Nejatzadeh-Barandozi F (2013) Antibacterial activities and antioxidant capacity of Aloe vera. Bioorg Med Chem Lett 3(1):5","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"70_CR94","first-page":"169","volume":"1","author":"N Oktaviani","year":"2018","unstructured":"Oktaviani N (2018) Antiulcer activity of Aloe vera in aspirin-induced mice. Paper Present Int Conf Interprofessional Health Collab Community Empower 1(1):169\u2013172","journal-title":"Paper Present Int Conf Interprofessional Health Collab Community Empower"},{"issue":"1","key":"70_CR95","doi-asserted-by":"publisher","DOI":"10.3390\/mi14010151","volume":"14","author":"SMR Oliveira","year":"2023","unstructured":"Oliveira SMR, Rebocho A, Ahmadpour E, Nissapatorn V, de Lours Pereira M (2023) Type 1 diabetes mellitus: a review on advances and challenges in creating insulin producing devices. Micromachines 14(1):151. https:\/\/doi.org\/10.3390\/mi14010151","journal-title":"Micromachines"},{"issue":"8","key":"70_CR96","doi-asserted-by":"publisher","first-page":"8110","DOI":"10.1021\/acsomega.2c08277","volume":"8","author":"AB Omer","year":"2023","unstructured":"Omer AB, Afzal O, Altamimi AS, Patil S, AlGhamdi SA, Alghamdi AM, Alzarea SI, Almalki WH, Kazmi I (2023) Neuroprotective effect of barbaloin on streptozotocin-induced cognitive dysfunction in rats via inhibiting cholinergic and neuroinflammatory cytokines pathway\u2500 TNF-\u03b1\/IL-1\u03b2\/IL-6\/NF-\u03baB. ACS Omega 8(8):8110\u20138118. https:\/\/doi.org\/10.1021\/acsomega.2c08277","journal-title":"ACS Omega"},{"issue":"2","key":"70_CR97","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00441-019-03015-9","volume":"377","author":"A Oryan","year":"2019","unstructured":"Oryan A, Alemzadeh E, Mohammadi AA, Moshiri A (2019) Healing potential of injectable Aloe vera hydrogel loaded by adipose-derived stem cell in skin tissue-engineering in a rat burn wound model. Cell Tissue Res 377(2):215\u2013227. https:\/\/doi.org\/10.1007\/s00441-019-03015-9","journal-title":"Cell Tissue Res"},{"issue":"9","key":"70_CR98","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1007\/s43032-024-01605-9","volume":"31","author":"D Pal","year":"2024","unstructured":"Pal D, Mitra D, Hazra S, Ghosh D (2024) Protective effect of Aloe vera (L.) on diabetes-induced oxidative stress linked spermiological co-morbidity in human and rat: an in vitro analysis. Reprod Sci 31(9):2685\u20132699. https:\/\/doi.org\/10.1007\/s43032-024-01605-9","journal-title":"Reprod Sci"},{"issue":"4","key":"70_CR99","doi-asserted-by":"publisher","first-page":"504","DOI":"10.4103\/0975-7406.90103","volume":"3","author":"A Pandey","year":"2011","unstructured":"Pandey A, Tripathi P, Pandey R, Srivatava R, Goswami S (2011) Alternative therapies useful in the management of diabetes: a systematic review. J Pharm Bioallied Sci 3(4):504\u2013512. https:\/\/doi.org\/10.4103\/0975-7406.90103","journal-title":"J Pharm Bioallied Sci"},{"issue":"1","key":"70_CR100","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1080\/13880209.2017.1371770","volume":"55","author":"CH Park","year":"2017","unstructured":"Park CH, Son HU, Yoo CY, Lee SH (2017) Low molecular-weight gel fraction of Aloe vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in alcohol-induced acute gastric lesion tissues. Pharm Biol 55(1):2110\u20132115. https:\/\/doi.org\/10.1080\/13880209.2017.1371770","journal-title":"Pharm Biol"},{"issue":"7","key":"70_CR101","doi-asserted-by":"publisher","first-page":"6813","DOI":"10.1021\/acsomega.2c07507","volume":"8","author":"P Phimnuan","year":"2023","unstructured":"Phimnuan P, Dirand Z, Tissot M, Worasakwutiphong S, Sittichokechaiwut A, Grandmottet F, Viyoch J, Viennet C (2023) Beneficial effects of a blended fibroin\/aloe gel extract film on the biomolecular mechanism (s) via the MAPK\/ERK pathway relating to diabetic wound healing. ACS Omega 8(7):6813\u20136824. https:\/\/doi.org\/10.1021\/acsomega.2c07507","journal-title":"ACS Omega"},{"issue":"8","key":"70_CR102","first-page":"129","volume":"9","author":"M Pichaivel","year":"2021","unstructured":"Pichaivel M, Krishnaraju K, Paulsamy P, Kuppan D, Venkatesan K (2021) Role of Aloe vera aqueous extract in dead space wound in diabetic rats. World J Pharm Sci 9(8):129\u2013132","journal-title":"World J Pharm Sci"},{"issue":"10","key":"70_CR103","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.6026\/973206300191015","volume":"19","author":"D Prakash","year":"2023","unstructured":"Prakash D, Margaret J, Subramanian NS, Maheshbhai CM, Babubhai CK, Kiranbhai CS, Chaudhary SK, Popatbhai U, Lodha HLK (2023) Effect of Aloe vera juice on type 2 diabetes mellitus among Indian patients. Bioinformation 19(10):1015. https:\/\/doi.org\/10.6026\/973206300191015","journal-title":"Bioinformation"},{"issue":"5","key":"70_CR104","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1080\/10826068.2019.1710712","volume":"50","author":"C Prasannaraja","year":"2020","unstructured":"Prasannaraja C, Kamalanathan A, Vijayalakshmi M, Venkataraman K (2020) A dipyrrole derivative from Aloe vera inhibits an anti-diabetic drug target Dipeptidyl Peptidase (DPP)-IV in vitro. Prep Biochem Biotechnol 50(5):511\u2013520. https:\/\/doi.org\/10.1080\/10826068.2019.1710712","journal-title":"Prep Biochem Biotechnol"},{"issue":"2","key":"70_CR105","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2217\/thy.11.8","volume":"8","author":"A Provilus","year":"2011","unstructured":"Provilus A, Abdallah M, McFarlane SI (2011) Weight gain associated with antidiabetic medications. Clin Pract 8(2):113\u2013120. https:\/\/doi.org\/10.2217\/thy.11.8","journal-title":"Clin Pract"},{"issue":"12","key":"70_CR106","doi-asserted-by":"publisher","first-page":"17842","DOI":"10.1021\/acsomega.8b02507","volume":"3","author":"ED Raczy\u0144ska","year":"2018","unstructured":"Raczy\u0144ska ED, Gal JF, Maria PC, Fontaine-Vive F (2018) Biguanide antidiabetic drugs: imeglimin exhibits higher proton basicity but smaller lithium-cation basicity than metformin in vacuo. ACS Omega 3(12):17842\u201317852. https:\/\/doi.org\/10.1021\/acsomega.8b02507","journal-title":"ACS Omega"},{"issue":"1","key":"70_CR107","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jtcme.2014.10.006","volume":"5","author":"MH Radha","year":"2015","unstructured":"Radha MH, Laxmipriya NP (2015) Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J Tradit Complement Med 5(1):21\u201326. https:\/\/doi.org\/10.1016\/j.jtcme.2014.10.006","journal-title":"J Tradit Complement Med"},{"key":"70_CR108","doi-asserted-by":"publisher","unstructured":"Ramadhini D, Ritonga, N (2022) The Effect of Aloe Vera Juice (Aloe Vera)on Blood Glucose Levels of Female White Rats (Rattus Norvegicus) Streptozotocin Induced Hyperglycemic. In: Tapanuli International Health Conference 2022 (TIHC 2022) 38\u201345. https:\/\/doi.org\/10.2991\/978-94-6463-032-9_7","DOI":"10.2991\/978-94-6463-032-9_7"},{"key":"70_CR109","doi-asserted-by":"publisher","unstructured":"Roney M, Issahaku AR, Govinden U, Gazali AM, Aluwi MFFM, Zamri NB (2024a) Diabetic wound healing of Aloe vera major phytoconstituents through TGF-\u03b21 suppression via in-silico docking, molecular dynamic simulation and pharmacokinetic studies. J Biomol Struct Dyn 42(24):13939\u201313952. https:\/\/doi.org\/10.1080\/07391102.2023.2279280","DOI":"10.1080\/07391102.2023.2279280"},{"key":"70_CR110","doi-asserted-by":"publisher","unstructured":"Roney M, Aluwi MFFM, Zamri NB (2024b) An in-silico approach to evaluate bioactive molecules of Aloe vera leaf extracts in inhibiting the Glycogen Synthase Kinase-3\u03b2 (GSK3-\u03b2) protein for faster diabetic wound healing potential. Biointerface Res Appl Chem 14(5):115. https:\/\/doi.org\/10.33263\/BRIAC145.115","DOI":"10.33263\/BRIAC145.115"},{"issue":"1","key":"70_CR111","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4314\/tjpr.v16i1.27","volume":"16","author":"A Sahar","year":"2017","unstructured":"Sahar A, Khan ZA, Ahmad M, Zahoor AF, Mansha A, Iqbal A (2017) Synthesis and antioxidant potential of some biscoumarin derivatives. Trop J Pharm Res 16(1):203\u2013210. https:\/\/doi.org\/10.4314\/tjpr.v16i1.27","journal-title":"Trop J Pharm Res"},{"issue":"1","key":"70_CR112","doi-asserted-by":"publisher","first-page":"81","DOI":"10.37962\/jbas.v12i1.294","volume":"12","author":"M Saleem","year":"2021","unstructured":"Saleem M, Sharif MK, Saleem R (2021) Antidiabetic potential of Aloe barbadensis Miller. RADS J Biol Res Appl Sci 12(1):81\u201389. https:\/\/doi.org\/10.37962\/jbas.v12i1.294","journal-title":"RADS J Biol Res Appl Sci"},{"issue":"6","key":"70_CR113","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061324","volume":"25","author":"M S\u00e1nchez","year":"2020","unstructured":"S\u00e1nchez M, Gonz\u00e1lez-Burgos E, Iglesias I, G\u00f3mez-Serranillos MP (2020) Pharmacological update properties of aloe vera and its major active constituents. Molecules 25(6):1324. https:\/\/doi.org\/10.3390\/molecules25061324","journal-title":"Molecules"},{"key":"70_CR114","doi-asserted-by":"publisher","unstructured":"Sandhiya T, Adalarasan S, Samyuktha U, Suganeshwari MD, Ramya R, Suganeshwari MD (2025) a randomized controlled trial on the therapeutic effect of aloe vera extract on diabetic foot ulcers.\u00a0Cureus\u00a017(7). https:\/\/doi.org\/10.7759\/cureus.88956","DOI":"10.7759\/cureus.88956"},{"key":"70_CR115","doi-asserted-by":"publisher","DOI":"10.1016\/j.deman.2021.100002","volume":"1","author":"AJ Scheen","year":"2021","unstructured":"Scheen AJ (2021) Sulphonylureas in the management of type 2 diabetes: to be or not to be? Diabetes Epidemiol Manage 1:100002. https:\/\/doi.org\/10.1016\/j.deman.2021.100002","journal-title":"Diabetes Epidemiol Manage"},{"key":"70_CR116","doi-asserted-by":"publisher","unstructured":"\u015eeker U, G\u00fczel BC, \u015eener D, Baygeldi SB, Y\u00fcksel M, Demirel \u00d6U, Soker S (2023) Nephroprotective effect of Aloe vera extract with regulation of oxidative stress, apoptosis and aquaporin 3 expression levels in streptozotocin induced diabetic rats. J Fac Pharm Ankara 47(2):438\u2013449. https:\/\/doi.org\/10.33483\/jfpau.1225760","DOI":"10.33483\/jfpau.1225760"},{"key":"70_CR117","doi-asserted-by":"publisher","unstructured":"Seyrek R, Soker S, Kaplan \u00d6, Ba\u015faran S\u00d6, A\u015f\u0131r F, Deveci E, \u015eeker U (2023) Effect of Aloe vera on MMP-1 And TIMP-1 expression on diabetic wound healing. J 6(2):204\u2013209. https:\/\/doi.org\/10.36516\/jocass.1268067","DOI":"10.36516\/jocass.1268067"},{"issue":"10","key":"70_CR118","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1002\/ptr.6465","volume":"33","author":"Z Shakib","year":"2019","unstructured":"Shakib Z, Shahraki N, Razavi BM, Hosseinzadeh H (2019) Aloe vera as an herbal medicine in the treatment of metabolic syndrome: a review. Phytother Res 33(10):2649\u20132660. https:\/\/doi.org\/10.1002\/ptr.6465","journal-title":"Phytother Res"},{"issue":"5","key":"70_CR119","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S2221-1691(15)30372-5","volume":"5","author":"M Shalabi","year":"2015","unstructured":"Shalabi M, Khilo K, Zakaria MM, Elsebaei MG, Abdo W, Awadin W (2015) Anticancer activity of Aloe vera and calligonum comosum extracts separetely on hepatocellular carcinoma cells. Asian Pac J Trop Biomed 5(5):375\u2013381. https:\/\/doi.org\/10.1016\/S2221-1691(15)30372-5","journal-title":"Asian Pac J Trop Biomed"},{"issue":"2","key":"70_CR120","first-page":"31","volume":"29","author":"P Sharma","year":"2014","unstructured":"Sharma P, Kharkwal AC, Kharkwal H, Abdin MZ, Varma A (2014) A review on pharmacological properties of Aloe vera. Int J Pharm Sci Rev Res 29(2):31\u201337","journal-title":"Int J Pharm Sci Rev Res"},{"key":"70_CR121","doi-asserted-by":"publisher","unstructured":"Sharma MK, Chauhan J, Kumar M, Joshi CK, Sharma S, Lal (2021) Prospects of Aloe vera and its bioactive compounds in diabetes: critical review. J Pure Appl Microbiol 15(4):1781\u20131797. https:\/\/doi.org\/10.22207\/JPAM.15.4.54","DOI":"10.22207\/JPAM.15.4.54"},{"issue":"1","key":"70_CR122","first-page":"1","volume":"11","author":"M Shoaib","year":"2022","unstructured":"Shoaib M, Bhargava M, Devpura G, Fiaz S (2022) A study assessing efficacy of Aloe vera as an adjuvant to conventional therapy in patients of type 2 diabetes mellitus with hyperlipidaemia. Int J Food Nutr Sci 11(1):1\u20139","journal-title":"Int J Food Nutr Sci"},{"key":"70_CR123","doi-asserted-by":"publisher","unstructured":"Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M, Imajo K, Takahashi H, Eguchi Y, Ono M, Nozaki Y, Hyogo H, Koseki M,Yoshida Y, Kawaguchi T, Kamada Y, Okanoue T, Nakajima A (2020) Antidiabetic treatments for diabetes with liver cirrhosis.\u00a0IOD 3(3):273\u20139. https:\/\/doi.org\/10.31031\/IOD.2020.03.000566","DOI":"10.31031\/IOD.2020.03.000566"},{"issue":"2","key":"70_CR124","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3177\/jnsv.66.176","volume":"66","author":"A Tada","year":"2020","unstructured":"Tada A, Misawa E, Tanaka M, Saito M, Nabeshima K, Yamauchi K, Abe F, Goto T, Kawada T (2020) Investigating anti-obesity effects by oral administration of Aloe vera gel extract (AVGE): possible involvement in activation of brown adipose tissue (BAT). J Nutr Sci Vitaminol 66(2):176\u2013184. https:\/\/doi.org\/10.3177\/jnsv.66.176","journal-title":"J Nutr Sci Vitaminol"},{"key":"70_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106015","volume":"113","author":"T Thilavech","year":"2024","unstructured":"Thilavech T, Chumroenvidhayakul S, Chusak C, Thunyakitpisal P, Adisakwattana S (2024) The effect of Aloe vera juice and acemannan on postprandial lipemic, antioxidant, and inflammatory response in high-fat meal fed overweight\/obese men: a randomized crossover-controlled study. J Funct Foods 113:106015. https:\/\/doi.org\/10.1016\/j.jff.2024.106015","journal-title":"J Funct Foods"},{"issue":"3","key":"70_CR126","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4103\/2229-3485.100660","volume":"3","author":"JA Vaz","year":"2012","unstructured":"Vaz JA, Patnaik A (2012) Diabetes mellitus: exploring the challenges in the drug development process. Perspect Clin Res 3(3):109\u2013112. https:\/\/doi.org\/10.4103\/2229-3485.100660","journal-title":"Perspect Clin Res"},{"issue":"1","key":"70_CR127","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/709893","volume":"2012","author":"FS Willard","year":"2012","unstructured":"Willard FS, Bueno AB, Sloop KW (2012) Small molecule drug discovery at the glucagon\u2010like peptide\u20101 receptor. J Diabetes Res 2012(1):709893. https:\/\/doi.org\/10.1155\/2012\/709893","journal-title":"J Diabetes Res"},{"key":"70_CR128","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.777561","volume":"12","author":"ML Willcox","year":"2021","unstructured":"Willcox ML, Elugbaju C, Al-Anbaki M, Lown M, Graz B (2021) Effectiveness of medicinal plants for glycaemic control in type 2 diabetes: an overview of meta-analyses of clinical trials. Front Pharmacol 12:777561. https:\/\/doi.org\/10.3389\/fphar.2021.777561","journal-title":"Front Pharmacol"},{"issue":"19","key":"70_CR129","doi-asserted-by":"publisher","first-page":"16824","DOI":"10.1021\/acsomega.3c00372","volume":"8","author":"A Yosboonruang","year":"2023","unstructured":"Yosboonruang A, Phimnuan P, Yakaew S, Oonkhanond B, Rawangkan A, Ross S, Ross G, Viyoch J (2023) Development of biocellulose sheet incorporating Aloe vera gel extract for diabetic wound healing. ACS Omega 8(19):16824\u201316832. https:\/\/doi.org\/10.1021\/acsomega.3c00372","journal-title":"ACS Omega"},{"key":"70_CR130","doi-asserted-by":"publisher","unstructured":"Younis N, Khan M, Hafeez MA, Hussain MI, Jan H (2022) Comparative effects of dried Aloe vera gel on blood sugar (glucose) in type-I and type-II diabetic patients. Riphah J Allied Health Sci 1(1). https:\/\/doi.org\/10.53389\/RJAHS.2022010107","DOI":"10.53389\/RJAHS.2022010107"},{"issue":"4","key":"70_CR131","doi-asserted-by":"publisher","first-page":"519","DOI":"10.5505\/ejm.2022.13285","volume":"27","author":"O Yunusoglu","year":"2022","unstructured":"Yunusoglu O, T\u00fcrkmen \u00d6, Berk\u00f6z M, Y\u0131ld\u0131r\u0131m M, Yal\u0131n S (2022) In vitro anti-obesity effect of Aloe vera extract through transcription factors and lipolysis-associated genes. Eastern J Med 27(4):519\u2013528. https:\/\/doi.org\/10.5505\/ejm.2022.13285","journal-title":"Eastern J Med"},{"issue":"5","key":"70_CR132","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2174\/1573406410666141229101130","volume":"11","author":"S Zaib","year":"2015","unstructured":"Zaib S, Umar Farooq Rizvi S, Aslam S, Ahmad M, Al-Rashida M, Iqbal J (2015) Monoamine oxidase inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones. Med Chem 11(5):497\u2013505. https:\/\/doi.org\/10.2174\/1573406410666141229101130","journal-title":"Med Chem"},{"key":"70_CR133","doi-asserted-by":"publisher","unstructured":"Zakaria MNZ, Aththar AF, Hamami SMA, Fai M, Rahayu S (2023) In silico study of \u03b1-amylase and \u03b1-glucosidase inhibitory compounds in Aloe vera as antidiabetic agent. Biotropika 11(1):28\u201337. https:\/\/doi.org\/10.21776\/ub.biotropika.2023.011.01.04","DOI":"10.21776\/ub.biotropika.2023.011.01.04"},{"issue":"1","key":"70_CR134","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0699-x","volume":"16","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Zhang C (2016) Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective. Curr Diabetes Rep 16(1):7. https:\/\/doi.org\/10.1007\/s11892-015-0699-x","journal-title":"Curr Diabetes Rep"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44446-026-00070-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44446-026-00070-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44446-026-00070-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:38:34Z","timestamp":1778675914000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44446-026-00070-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":134,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["70"],"URL":"https:\/\/doi.org\/10.1007\/s44446-026-00070-6","relation":{},"ISSN":["1319-0164","2213-7475"],"issn-type":[{"value":"1319-0164","type":"print"},{"value":"2213-7475","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]},"assertion":[{"value":"30 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing financial interests\/conflict of interest related to this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"11"}}