{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:47:17Z","timestamp":1792540037889,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Food Sci Anim Resour"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s44463-026-00057-w","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:48:35Z","timestamp":1775112515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Health benefits and value addition of bovine colostrum (BC): a comprehensive review of its nutritional and functional potential"],"prefix":"10.1007","volume":"46","author":[{"given":"Sawera","family":"Riaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musarrat","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleeza","family":"Amjad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunaira","family":"Basharat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakhar","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Naeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Tamale","family":"Ndagire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"57_CR1","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1056\/NEJM199209103271101","volume":"327","author":"MC Allison","year":"1992","unstructured":"Allison, M. C., Howatson, A. G., Torrance, C. J., Lee, F. D., & Russell, R. I. (1992). Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. New England Journal of Medicine, 327, 749\u2013754.","journal-title":"New England Journal of Medicine"},{"key":"57_CR2","doi-asserted-by":"publisher","first-page":"651721","DOI":"10.3389\/fnut.2021.651721","volume":"8","author":"A Arslan","year":"2021","unstructured":"Arslan, A., Kaplan, M., Duman, H., Bayraktar, A., Ert\u00fcrk, M., Henrick, B. M., et al. (2021). Bovine colostrum and its potential for human health and nutrition. Frontiers in Nutrition, 8, 651721.","journal-title":"Frontiers in Nutrition"},{"key":"57_CR3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12011-023-03658-4","volume":"202","author":"MF Ashraf","year":"2024","unstructured":"Ashraf, M. F., Zubair, D., Bashir, M. N., Alagawany, M., Ahmed, S., Shah, Q. A., et al. (2024). Nutraceutical and health-promoting potential of lactoferrin, an iron-binding protein in human and animal: Current knowledge. Biological Trace Element Research, 202, 56\u201372.","journal-title":"Biological Trace Element Research"},{"issue":"3","key":"57_CR4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1515\/jcim-2014-0039","volume":"12","author":"S Bagwe","year":"2015","unstructured":"Bagwe, S., Tharappel, L. J., Kaur, G., & Buttar, H. S. (2015). Bovine colostrum: An emerging nutraceutical. Journal of Complementary and Integrative Medicine, 12(3), 175\u2013185.","journal-title":"Journal of Complementary and Integrative Medicine"},{"key":"57_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01100","volume":"11","author":"S Bagwe-Parab","year":"2020","unstructured":"Bagwe-Parab, S., Yadav, P., Kaur, G., Tuli, H. S., & Buttar, H. S. (2020). Therapeutic applications of human and bovine colostrum in the treatment of gastrointestinal diseases and distinctive cancer types: The current evidence. Frontiers in Pharmacology, 11, Article 01100.","journal-title":"Frontiers in Pharmacology"},{"key":"57_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/tropej\/fmw029","volume":"63","author":"B Balachandran","year":"2017","unstructured":"Balachandran, B., Dutta, S., Singh, R., Prasad, R., & Kumar, P. (2017). Bovine colostrum in prevention of necrotizing enterocolitis and sepsis in very low birth weight neonates: A randomized, double-blind, placebo-controlled pilot trial. Journal of Tropical Pediatrics, 63, 10\u201317.","journal-title":"Journal of Tropical Pediatrics"},{"key":"57_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-809868-4.00001-7","volume-title":"Dairy in human health and disease across the lifespan","author":"HS Buttar","year":"2017","unstructured":"Buttar, H. S., Bagwe, S. M., Bhullar, S. K., & Kaur, G. (2017). Health benefits of bovine colostrum in children and adults. In Dairy in human health and disease across the lifespan (pp. 3-20). Academic Press."},{"key":"57_CR8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2174\/1389557523666230517113936","volume":"24","author":"G Chawla","year":"2024","unstructured":"Chawla, G., Pradhan, T., & Gupta, O. (2024). An insight into the combat strategies for the treatment of type 2 diabetes mellitus. Mini Reviews in Medicinal Chemistry, 24, 403\u2013430.","journal-title":"Mini Reviews in Medicinal Chemistry"},{"issue":"4","key":"57_CR9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/MCO.0000000000000189","volume":"18","author":"AI Coelho","year":"2015","unstructured":"Coelho, A. I., Berry, G. T., & Rubio-Gozalbo, M. E. (2015). Galactose metabolism and health. Current Opinion in Clinical Nutrition & Metabolic Care, 18(4), 422\u2013427.","journal-title":"Current Opinion in Clinical Nutrition & Metabolic Care"},{"issue":"1","key":"57_CR13","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3168\/jds.2016-10892","volume":"100","author":"C Cummins","year":"2017","unstructured":"Cummins, C., Berry, D. P., Murphy, J. P., Lorenz, I., & Kennedy, E. (2017). The effect of colostrum storage conditions on dairy heifer calf serum Immunoglobulin G concentration and preweaning health and growth rate. Journal of Dairy Science, 100(1), 525\u2013535.","journal-title":"Journal of Dairy Science"},{"key":"57_CR14","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00394-019-02004-6","volume":"59","author":"G Davison","year":"2020","unstructured":"Davison, G., Jones, A. W., Marchbank, T., & Playford, R. J. (2020). Oral bovine colostrum supplementation does not increase Circulating insulin-like growth factor-1 concentration in healthy adults: Results from short-and long-term administration studies. European Journal of Nutrition, 59, 1473\u20131479.","journal-title":"European Journal of Nutrition"},{"key":"57_CR15","first-page":"88","volume":"7","author":"J de la Cabada Bauche","year":"2011","unstructured":"de la Cabada Bauche, J., & DuPont, H. L. (2011). New developments in traveler\u2019s diarrhea. Gastroenterology & Hepatology, 7, 88.","journal-title":"Gastroenterology & Hepatology"},{"issue":"4","key":"57_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1017\/S0022029922000711","volume":"89","author":"K Denholm","year":"2022","unstructured":"Denholm, K. (2022). A review of bovine colostrum preservation techniques. Journal of Dairy Research, 89(4), 345\u2013354.","journal-title":"Journal of Dairy Research"},{"key":"57_CR17","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1123\/ijsnem.2013-0182","volume":"24","author":"WR Duff","year":"2014","unstructured":"Duff, W. R., Chilibeck, P. D., Rooke, J. J., Kaviani, M., Krentz, J. R., & Haines, D. M. (2014). The effect of bovine colostrum supplementation in older adults during resistance training. International Journal of Sport Nutrition and Exercise Metabolism, 24, 276\u2013285.","journal-title":"International Journal of Sport Nutrition and Exercise Metabolism"},{"key":"57_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1214514","volume":"14","author":"H Duman","year":"2023","unstructured":"Duman, H., & Karav, S. (2023). Bovine colostrum and its potential contributions for treatment and prevention of COVID-19. Frontiers in Immunology, 14, Article 1214514.","journal-title":"Frontiers in Immunology"},{"key":"57_CR19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.nutos.2022.07.001","volume":"44","author":"MM El-Loly","year":"2022","unstructured":"El-Loly, M. M. (2022). Colostrum ingredients, its nutritional and health benefits-an overview. Clinical Nutrition Open Science, 44, 126\u2013143.","journal-title":"Clinical Nutrition Open Science"},{"key":"57_CR21","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.3168\/jds.2019-17357","volume":"103","author":"A Fischer-Tlustos","year":"2020","unstructured":"Fischer-Tlustos, A., Hertogs, K., Van Niekerk, J., Nagorske, M., Haines, D., & Steele, M. (2020). Oligosaccharide concentrations in colostrum, transition milk, and mature milk of primi-and multiparous Holstein cows during the first week of lactation. Journal of Dairy Science, 103, 3683\u20133695.","journal-title":"Journal of Dairy Science"},{"key":"57_CR22","first-page":"3","volume":"11","author":"IP Georgiev","year":"2008","unstructured":"Georgiev, I. P. (2008). Differences in chemical composition between cow colostrum and milk. Bulgarian Journal of Veterinary Medicine, 11, 3\u201312.","journal-title":"Bulgarian Journal of Veterinary Medicine"},{"issue":"1","key":"57_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cvfa.2007.10.005","volume":"24","author":"S Godden","year":"2008","unstructured":"Godden, S. (2008). Colostrum management for dairy calves. Veterinary Clinics of North America. Food Animal Practice, 24(1), 19\u201339.","journal-title":"Veterinary Clinics of North America. Food Animal Practice"},{"key":"57_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2019.07.005","volume":"35","author":"SM Godden","year":"2019","unstructured":"Godden, S. M., Lombard, J. E., & Woolums, A. R. (2019). Colostrum management for dairy calves. Veterinary Clinics of North America. Food Animal Practice, 35, Article 535.","journal-title":"Veterinary Clinics of North America. Food Animal Practice"},{"key":"57_CR26","unstructured":"Henry, D., & McGettigan, P. (2003). Epidemiology overview of Gastrointestinal and renal toxicity of NSAIDs. International Journal of Clinical Practice Supplement, 43\u201349."},{"issue":"3","key":"57_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation6030093","volume":"6","author":"I Hyrslova","year":"2020","unstructured":"Hyrslova, I., Krausova, G., Michlova, T., Kana, A., & Curda, L. (2020). Fermentation ability of bovine colostrum by different probiotic strains. Fermentation, 6(3), Article 93.","journal-title":"Fermentation"},{"key":"57_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100668","volume":"15","author":"SA Jensen","year":"2022","unstructured":"Jensen, S. A., Fiocchi, A., Baars, T., Jordakieva, G., Nowak-Wegrzyn, A., Pali-Sch\u00f6ll, I., et al. (2022). Diagnosis and rationale for action against Cow\u2019s Milk Allergy (DRACMA) Guidelines update-III-Cow\u2019s milk allergens and mechanisms triggering immune activation. The World Allergy Organization Journal, 15, Article 100668.","journal-title":"The World Allergy Organization Journal"},{"key":"57_CR29","doi-asserted-by":"crossref","unstructured":"JE\u017dEK, J., MALOVRH, T., & KLINKON, M. (2012). Serum immunoglobulin (IgG, IgM, IgA) concentration in cows and their calves. Acta agriculturae Slovenica. Suplement, 3, 295\u2013298.","DOI":"10.14720\/aas-s.2012.3.19157"},{"key":"57_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00394-017-1597-6","volume":"58","author":"AW Jones","year":"2019","unstructured":"Jones, A. W., March, D. S., Thatcher, R., Diment, B., Walsh, N. P., & Davison, G. (2019). The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: A randomised controlled trial. European Journal of Nutrition, 58, 335\u2013344.","journal-title":"European Journal of Nutrition"},{"key":"57_CR31","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3109\/1040841X.2011.556598","volume":"37","author":"M Kachrimanidou","year":"2011","unstructured":"Kachrimanidou, M., & Malisiovas, N. (2011). Clostridium difficile infection: A comprehensive review. Critical Reviews in Microbiology, 37, 178\u2013187.","journal-title":"Critical Reviews in Microbiology"},{"key":"57_CR32","doi-asserted-by":"publisher","first-page":"796824","DOI":"10.3389\/fphar.2021.796824","volume":"12","author":"M Kaplan","year":"2022","unstructured":"Kaplan, M., Arslan, A., Duman, H., Karyelio\u011flu, M., Baydemir, B., G\u00fcnar, B. B., & Karav, S. (2022). Production of bovine colostrum for human consumption to improve health. Frontiers in Pharmacology, 12, 796824.","journal-title":"Frontiers in Pharmacology"},{"key":"57_CR33","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1046\/j.1365-2036.2002.01354.x","volume":"16","author":"Z Khan","year":"2002","unstructured":"Khan, Z., Macdonald, C., Wicks, A., Holt, M., Floyd, D., Ghosh, S., et al. (2002). Use of the \u2018nutriceutical\u2019, bovine colostrum, for the treatment of distal colitis: Results from an initial study. Alimentary Pharmacology & Therapeutics, 16, 1917\u20131922.","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"57_CR34","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s002280000163","volume":"56","author":"U Klotz","year":"2000","unstructured":"Klotz, U. (2000). The role of aminosalicylates at the beginning of the new millennium in the treatment of chronic inflammatory bowel disease. European Journal of Clinical Pharmacology, 56, 353\u2013362.","journal-title":"European Journal of Clinical Pharmacology"},{"key":"57_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00023","volume":"5","author":"R Kolenda","year":"2015","unstructured":"Kolenda, R., Burdukiewicz, M., & Schierack, P. (2015). A systematic review and meta-analysis of the epidemiology of pathogenic Escherichia coli of calves and the role of calves as reservoirs for human pathogenic E. coli. Frontiers in Cellular and Infection Microbiology, 5, Article 23.","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"57_CR36","doi-asserted-by":"publisher","first-page":"G477","DOI":"10.1152\/ajpgi.00281.2010","volume":"300","author":"T Marchbank","year":"2011","unstructured":"Marchbank, T., Davison, G., Oakes, J. R., Ghatei, M. A., Patterson, M., Moyer, M. P., et al. (2011). The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300, G477\u2013G484.","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"57_CR37","doi-asserted-by":"publisher","first-page":"105944","DOI":"10.1016\/j.idairyj.2024.105944","volume":"155","author":"F McDermott","year":"2024","unstructured":"McDermott, F., Kennedy, E., Tobin, J. T., Egan, M., O\u2019Callaghan, T. F., Brennan, L., et al. (2024). Protein and oligosaccharide composition of colostrum and transition milk from pasture-based dairy cows supplemented prepartum with inorganic selenium, organic selenium or rumen-protected choline. International Dairy Journal, 155, 105944.","journal-title":"International Dairy Journal"},{"key":"57_CR38","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s13594-015-0258-x","volume":"96","author":"BA McGrath","year":"2016","unstructured":"McGrath, B. A., Fox, P. F., McSweeney, P. L., & Kelly, A. L. (2016). Composition and properties of bovine colostrum: A review. Dairy Science & Technology, 96, 133\u2013158.","journal-title":"Dairy Science & Technology"},{"key":"57_CR39","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.4.1144","author":"A Mero","year":"1997","unstructured":"Mero, A., Miikkulainen, H., Riski, J., Pakkanen, R., Aalto, J., & Takala, T. (1997). Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. Journal of Applied Physiology. https:\/\/doi.org\/10.1152\/jappl.1997.83.4.1144","journal-title":"Journal of Applied Physiology"},{"key":"57_CR40","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1016\/j.bpj.2009.09.030","volume":"97","author":"R Mir","year":"2009","unstructured":"Mir, R., Singh, N., Vikram, G., Kumar, R. P., Sinha, M., Bhushan, A., et al. (2009). The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced Gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin. Biophysical Journal, 97, 3178\u20133186.","journal-title":"Biophysical Journal"},{"key":"57_CR41","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.micpath.2018.02.032","volume":"117","author":"A Mirhoseini","year":"2018","unstructured":"Mirhoseini, A., Amani, J., & Nazarian, S. (2018). Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it. Microbial Pathogenesis, 117, 162\u2013169.","journal-title":"Microbial Pathogenesis"},{"key":"57_CR42","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/j.1651-2227.1995.tb13814.x","volume":"84","author":"A Mitra","year":"1995","unstructured":"Mitra, A., Mahalanabis, D., Ashraf, H., Unicomb, L., Eeckels, R., & Tzipori, S. (1995). Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: A double-blind, controlled clinical trial. Acta Paediatrica, 84, 996\u20131001.","journal-title":"Acta Paediatrica"},{"key":"57_CR43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-981-19-9410-4_5","volume-title":"Textbook of Veterinary Physiology","author":"J Mukherjee","year":"2023","unstructured":"Mukherjee, J., Das, P. K., Banerjee, D., & Mukherjee, A. (2023). Immune System. Textbook of Veterinary Physiology (pp. 89\u2013110). Springer."},{"key":"57_CR44","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nrgastro.2016.119","volume":"13","author":"DF Ni\u00f1o","year":"2016","unstructured":"Ni\u00f1o, D. F., Sodhi, C. P., & Hackam, D. J. (2016). Necrotizing enterocolitis: New insights into pathogenesis and mechanisms. Nature Reviews Gastroenterology & Hepatology, 13, 590\u2013600.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"57_CR45","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/B978-0-12-819470-6.00076-7","volume-title":"Present knowledge in food safety","author":"V Ntuli","year":"2023","unstructured":"Ntuli, V., Sibanda, T., Elegbeleye, J. A., Mugadza, D. T., Seifu, E., & Buys, E. M. (2023). Dairy production: Microbial safety of raw milk and processed milk products. Present knowledge in food safety (pp. 439\u2013454). Elsevier."},{"key":"57_CR46","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, T. F., O\u2019Donovan, M., Murphy, J. P., Sugrue, K., Mannion, D., McCarthy, W. P., & Hickey, R. M. (2020). JT Tobin Evolution of the bovine milk fatty acid profile\u2014From colostrum to milk five days post parturition., 2020, 104. https:\/\/doi.org\/10.1016\/j. idairyj, 104655.","DOI":"10.1016\/j.idairyj.2020.104655"},{"key":"57_CR47","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3109\/00365521.2011.574726","volume":"46","author":"W Otto","year":"2011","unstructured":"Otto, W., Najnigier, B., Stelmasiak, T., & Robins-Browne, R. M. (2011). Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers. Scandinavian Journal of Gastroenterology, 46, 862\u2013868.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"57_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010265","volume":"13","author":"RJ Playford","year":"2021","unstructured":"Playford, R. J., & Weiser, M. J. (2021). Bovine colostrum: Its constituents and uses. Nutrients, 13, Article 265.","journal-title":"Nutrients"},{"key":"57_CR50","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/ajcn\/72.1.5","volume":"72","author":"RJ Playford","year":"2000","unstructured":"Playford, R. J., Macdonald, C. E., & Johnson, W. S. (2000). Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. American Journal of Clinical Nutrition, 72, 5\u201314.","journal-title":"American Journal of Clinical Nutrition"},{"key":"57_CR51","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1042\/cs1000627","volume":"100","author":"RJ Playford","year":"2001","unstructured":"Playford, R. J., CALNAN, M. A. C. D. O. N. A. L. D. C. E., FLOYD, D. P., PODAS, D. N., T., JOHNSON, W., et al. (2001). Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clinical Science, 100, 627\u2013633.","journal-title":"Clinical Science"},{"key":"57_CR52","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1039\/D3FB00256J","volume":"2","author":"A Ramani","year":"2024","unstructured":"Ramani, A., Taherabbas, S., & Manik, S. (2024). Bovine colostrum as a promising nutraceutical: A systematic review. Sustainable Food Technology, 2, 531\u2013547.","journal-title":"Sustainable Food Technology"},{"key":"57_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.668639","volume":"8","author":"L Robbers","year":"2021","unstructured":"Robbers, L., Jorritsma, R., Nielen, M., & Koets, A. (2021). A scoping review of on-farm colostrum management practices for optimal transfer of immunity in dairy calves. Frontiers in Veterinary Science, 8, Article 668639.","journal-title":"Frontiers in Veterinary Science"},{"key":"57_CR54","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0767","author":"B Sadeghirad","year":"2018","unstructured":"Sadeghirad, B., Morgan, R. L., Zeraatkar, D., Zea, A. M., Couban, R., Johnston, B. C., et al. (2018). Human and bovine colostrum for prevention of necrotizing enterocolitis: A meta-analysis. Pediatrics. https:\/\/doi.org\/10.1542\/peds.2018-0767","journal-title":"Pediatrics"},{"key":"57_CR56","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1097\/00006454-199812000-00010","volume":"17","author":"SA Sarker","year":"1998","unstructured":"Sarker, S. A., Casswall, T. H., Mahalanabis, D., Alam, N. H., Albert, M. J., Br\u00fcssow, H., et al. (1998). Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. The Pediatric infectious disease journal, 17, 1149\u20131154.","journal-title":"The Pediatric infectious disease journal"},{"key":"57_CR58","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1128\/CMR.00032-07","volume":"21","author":"GN Schroeder","year":"2008","unstructured":"Schroeder, G. N., & Hilbi, H. (2008). Molecular pathogenesis of Shigella spp.: Controlling host cell signaling, invasion, and death by type III secretion. Clinical Microbiology Reviews, 21, 134\u2013156.","journal-title":"Clinical Microbiology Reviews"},{"key":"57_CR59","doi-asserted-by":"publisher","first-page":"850","DOI":"10.3390\/ani13050850","volume":"13","author":"V Serra","year":"2023","unstructured":"Serra, V., Castrica, M., Agradi, S., Curone, G., Vigo, D., Di Giancamillo, A., et al. (2023). Antioxidant activity of different tissues from rabbits fed dietary bovine colostrum supplementation. Animals, 13, 850.","journal-title":"Animals"},{"key":"57_CR60","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.2165\/11317860-000000000-00000","volume":"39","author":"CM Shing","year":"2009","unstructured":"Shing, C. M., Hunter, D. C., & Stevenson, L. M. (2009). Bovine colostrum supplementation and exercise performance: Potential mechanisms. Sports Medicine, 39, 1033\u20131054.","journal-title":"Sports Medicine"},{"key":"57_CR61","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1136\/gut.43.4.506","volume":"43","author":"G Sigthorsson","year":"1998","unstructured":"Sigthorsson, G., Tibble, J., Hayllar, J., Menzies, I., Macpherson, A., Moots, R., et al. (1998). Intestinal permeability and inflammation in patients on NSAIDs. Gut, 43, 506\u2013511.","journal-title":"Gut"},{"key":"57_CR62","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1590\/fst.14619","volume":"39","author":"E Silva","year":"2019","unstructured":"Silva, E., Rangel, A., M\u00fcrmam, L., Bezerra, M. F., & Oliveira, J. (2019). Bovine colostrum: Benefits of its use in human food. Food Science and Technology, 39, 355\u2013362.","journal-title":"Food Science and Technology"},{"key":"57_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/ani14071130","volume":"14","author":"FG Silva","year":"2024","unstructured":"Silva, F. G., Silva, S. R., Pereira, A. M., Cerqueira, J. L., & Concei\u00e7\u00e3o, C. (2024). A comprehensive review of bovine colostrum components and selected aspects regarding their impact on neonatal calf physiology. Animals, 14, Article 1130.","journal-title":"Animals"},{"key":"57_CR64","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.pedneo.2017.04.003","volume":"58","author":"R Snyder","year":"2017","unstructured":"Snyder, R., Herdt, A., Mejias-Cepeda, N., Ladino, J., Crowley, K., & Levy, P. (2017). Early provision of oropharyngeal colostrum leads to sustained breast milk feedings in preterm infants. Pediatrics & Neonatology, 58, 534\u2013540.","journal-title":"Pediatrics & Neonatology"},{"key":"57_CR65","doi-asserted-by":"crossref","unstructured":"Stockler, J., & Chamorro, M. F. (2021). Colostrum: A review\u00a0Bovine Reproduction,\u00a0(pp. 924\u2013944).\u00a0","DOI":"10.1002\/9781119602484.ch75"},{"key":"57_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00052","volume":"5","author":"LH Ulfman","year":"2018","unstructured":"Ulfman, L. H., Leusen, J. H., Savelkoul, H. F., Warner, J. O., & Van Neerven, R. J. (2018). Effects of bovine immunoglobulins on immune function, allergy, and infection. Frontiers in Nutrition, 5, Article 52.","journal-title":"Frontiers in Nutrition"},{"key":"57_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3168\/jds.2019-16959","volume":"103","author":"I Van Hese","year":"2020","unstructured":"Van Hese, I., Goossens, K., Vandaele, L., & Opsomer, G. (2020). Invited review: MicroRNAs in bovine colostrum\u2014Focus on their origin and potential health benefits for the calf. Journal of Dairy Science, 103, 1\u201315.","journal-title":"Journal of Dairy Science"},{"issue":"1","key":"57_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010173","volume":"18","author":"V Verardo","year":"2017","unstructured":"Verardo, V., G\u00f3mez-Caravaca, A. M., Arr\u00e1ez-Rom\u00e1n, D., & Hettinga, K. (2017). Recent advances in phospholipids from colostrum, milk and dairy by-products. International Journal of Molecular Sciences, 18(1), Article 173.","journal-title":"International Journal of Molecular Sciences"},{"key":"57_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/ani10020337","volume":"10","author":"R Wang","year":"2020","unstructured":"Wang, R., Han, Z., Ji, R., Xiao, Y., Si, R., Guo, F., et al. (2020). Antibacterial activity of trypsin-hydrolyzed camel and cow whey and their fractions. Animals, 10, Article 337.","journal-title":"Animals"},{"key":"57_CR70","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3390\/nu16142359","volume":"16","author":"YM Yal\u00e7\u0131nta\u015f","year":"2024","unstructured":"Yal\u00e7\u0131nta\u015f, Y. M., Duman, H., L\u00f3pez, J. M. M., Portocarrero, A. C. M., Lombardo, M., Khallouki, F., et al. (2024). Revealing the potency of growth factors in bovine colostrum. Nutrients, 16, 2359.","journal-title":"Nutrients"},{"key":"57_CR71","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/ani15020185","volume":"15","author":"P Yu","year":"2025","unstructured":"Yu, P., & Satyaraj, E. (2025). Effect of bovine colostrum on canine immune health. Animals, 15, 185.","journal-title":"Animals"},{"key":"57_CR72","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/molecules24010148","volume":"24","author":"X Zhao","year":"2019","unstructured":"Zhao, X., Xu, X. X., Liu, Y., Xi, E. Z., An, J. J., Tabys, D., et al. (2019). The in vitro protective role of bovine lactoferrin on intestinal epithelial barrier. Molecules, 24, 148.","journal-title":"Molecules"}],"container-title":["Food Science of Animal Resources"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44463-026-00057-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44463-026-00057-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44463-026-00057-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:03:42Z","timestamp":1775117022000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44463-026-00057-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["57"],"URL":"https:\/\/doi.org\/10.1007\/s44463-026-00057-w","relation":{},"ISSN":["2636-0772","2636-0780"],"issn-type":[{"value":"2636-0772","type":"print"},{"value":"2636-0780","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"13 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All authors are willing for publication of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"All the co-authors are willing to participate in this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not Applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"55"}}