{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T20:59:38Z","timestamp":1743109178059,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":20,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071608715"},{"type":"electronic","value":"9781071608722"}],"license":[{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-0872-2_15","type":"book-chapter","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T17:02:46Z","timestamp":1598029366000},"page":"271-284","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Conception of Plasmid DNA and Polyethylenimine Delivery Systems with Potential Application in DNA Vaccines Field"],"prefix":"10.1007","author":[{"given":"Diana","family":"Costa","sequence":"first","affiliation":[]},{"given":"\u00c2ngela","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"R\u00faben","family":"Faria","sequence":"additional","affiliation":[]},{"given":"Ana Raquel","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o A.","family":"Queiroz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,8,22]]},"reference":[{"key":"15_CR1","first-page":"45","volume":"146","author":"W Sun","year":"2019","unstructured":"Sun W, Shi Q, Zhang H et al (2019) Advances in the techniques and methodologies of cancer gene therapy. Disc Med 146:45\u201355","journal-title":"Disc Med"},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12645-018-0040-x","volume":"9","author":"CM McCrudden","year":"2018","unstructured":"McCrudden CM, McBride JW, McCaffrey J et al (2018) Gene therapy with RALA\/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer. Cancer Nano 9:5","journal-title":"Cancer Nano"},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1089\/hum.2018.015","volume":"29","author":"C Hinderer","year":"2018","unstructured":"Hinderer C, Katz N, Buza EL et al (2018) Severe toxicity in nonhuman primates and piglets following high-dose intravenous administration of an AVV vector expressing human SMN. Hum Gene Ther 29:285\u2013298","journal-title":"Hum Gene Ther"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/polym11030514","volume":"11","author":"A Rey-Rico","year":"2019","unstructured":"Rey-Rico A, Cucchiarini M (2019) Supramolecular cyclodextrin-based hydrogels for controlled gene delivery. Polymers 11:514\u2013523","journal-title":"Polymers"},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.colsurfb.2019.03.029","volume":"178","author":"D Costa","year":"2019","unstructured":"Costa D, Albuquerque T, Queiroz JA et al (2019) A co-delivery platform based on plasmid DNA peptide-surfactant complexes: formation, characterization and release behaviour. Colloids Surf B Biointerfaces 178:430\u2013438","journal-title":"Colloids Surf B Biointerfaces"},{"key":"15_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1021\/acs.molpharmaceut.6b00823","volume":"14","author":"E Coutinho","year":"2017","unstructured":"Coutinho E, Batista C, Sousa F et al (2017) Mitochondrial gene therapy: advances in mitochondrial gene cloning, plasmid production and nanosystems targeted to mitochondria. Mol Pharm 14:626\u2013638","journal-title":"Mol Pharm"},{"key":"15_CR7","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1002\/cmdc.201700391","volume":"12","author":"B Du","year":"2017","unstructured":"Du B, Gu X, Han X et al (2017) Lipid-coated gold nanoparticles functionalized by folic acid as gene vectors for targeted gene delivery in vitro and in vivo. ChemMedChem 12:1768\u20131775","journal-title":"ChemMedChem"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.colsurfb.2015.06.005","volume":"133","author":"D Costa","year":"2015","unstructured":"Costa D, Briscoe WH, Queiroz JA (2015) Polyethylenimine coated plasmid DNA-surfactant complexes as potential gene delivery systems. Colloids Surf B Biointerfaces 133:156\u2013163","journal-title":"Colloids Surf B Biointerfaces"},{"key":"15_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186194","volume":"12","author":"CF Temprana","year":"2017","unstructured":"Temprana CF, Prieto MJ, Igart\u00faa DE et al (2017) Diacetylenic lipids in the design of stable lipopolymers able to complex and protect plasmid DNA. PLoS One 12:e0186194","journal-title":"PLoS One"},{"key":"15_CR10","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1021\/acs.biomac.7b00567","volume":"18","author":"H Chang","year":"2017","unstructured":"Chang H, Zhang J, Wang H et al (2017) A combination of guanidyl and phenyl groups on a dendrimer enables efficient siRNA and DNA delivery. Biomacromolecules 18:2371\u20132378","journal-title":"Biomacromolecules"},{"key":"15_CR11","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.actbio.2017.06.037","volume":"65","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Liu L, Lin L et al (2017) In-situ dual-crosslinked nanoparticles for tumor targeting gene delivery. Acta Biomater 65:349\u2013362","journal-title":"Acta Biomater"},{"key":"15_CR12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/s41417-017-0004-z","volume":"25","author":"OK Appelbe","year":"2018","unstructured":"Appelbe OK, Kim BK, Rymut N et al (2018) Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex. Cancer Gene Ther 25:196\u2013206","journal-title":"Cancer Gene Ther"},{"key":"15_CR13","doi-asserted-by":"publisher","first-page":"4346","DOI":"10.1021\/ma2027963","volume":"45","author":"Z Dai","year":"2012","unstructured":"Dai Z, Wu C (2012) How does DNA complex with polyethylenimine with different chain lengths and topologies in their aqueous solution mixtures? Macromolecules 45:4346\u20134353","journal-title":"Macromolecules"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.colsurfb.2018.06.063","volume":"170","author":"D Costa","year":"2018","unstructured":"Costa D, Valente AJM, Queiroz JA et al (2018) Finding the ideal polyethylenimine-plasmid DNA system for co-delivery of payloads in cancer therapy. Colloids Surf B Biointerfaces 170:627\u2013636","journal-title":"Colloids Surf B Biointerfaces"},{"key":"15_CR15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s10904-014-0135-8","volume":"25","author":"CY Tay","year":"2015","unstructured":"Tay CY, Menon N, Leong DT et al (2015) Molecular architecture governs cytotoxicity and gene transfection efficacy of polyethylenimine based nanoplexes in mammalian cell lines. J Inorg Organomet Polym 25:30\u2013311","journal-title":"J Inorg Organomet Polym"},{"key":"15_CR16","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1248\/cpb.c16-00454","volume":"64","author":"K Utsuno","year":"2016","unstructured":"Utsuno K, Kono H, Tanaka E et al (2016) Low molecular weight branched PEI binding to linear DNA. Chem Pharm Bull 64:1484\u20131491","journal-title":"Chem Pharm Bull"},{"key":"15_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.carbpol.2015.08.053","volume":"135","author":"JP Nam","year":"2016","unstructured":"Nam JP, Nah JW (2016) Target gene delivery from targeting ligand conjugated chitosan-PEI copolymer for cancer therapy. Carbohydr Polym 135:153\u2013161","journal-title":"Carbohydr Polym"},{"key":"15_CR18","doi-asserted-by":"publisher","first-page":"112488","DOI":"10.1016\/j.molliq.2020.112488","volume":"302","author":"A Sousa","year":"2020","unstructured":"Sousa A, Faria R, Albuquerque T et al (2020) Design of experiments to select triphenylphosphonium-polyplexes with suitable physicochemical properties for mitochondrial gene therapy. J Mol Liq 302:112488. https:\/\/doi.org\/10.1016\/j.molliq.2020.112488","journal-title":"J Mol Liq"},{"key":"15_CR19","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/cbin.10459","volume":"39","author":"S Salatin","year":"2015","unstructured":"Salatin S, Maleki Dizaj S, Yari A (2015) Effect of the surface modification, size and shape on cellular uptake of nanoparticles. Cell Biol Int 39:881\u2013890","journal-title":"Cell Biol Int"},{"key":"15_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/srep24567","volume":"6","author":"X Liu","year":"2016","unstructured":"Liu X, Wu F, Tian Y et al (2016) Size dependent cellular uptake of rod-like bionanoparticles with different aspect ratios. Sci Rep 6:24567","journal-title":"Sci Rep"}],"container-title":["Methods in Molecular Biology","DNA Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-0872-2_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:59:49Z","timestamp":1662166789000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-0872-2_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,22]]},"ISBN":["9781071608715","9781071608722"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-0872-2_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2020,8,22]]},"assertion":[{"value":"22 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}