{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T19:27:56Z","timestamp":1744918076361},"publisher-location":"New York, NY","reference-count":141,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781461484431"},{"type":"electronic","value":"9781461484448"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-1-4614-8444-8_2","type":"book-chapter","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T12:36:57Z","timestamp":1382963817000},"page":"5-24","source":"Crossref","is-referenced-by-count":20,"title":["Biogenesis and Physiology of MicroRNAs"],"prefix":"10.1007","author":[{"given":"Carlos A.","family":"Melo","sequence":"first","affiliation":[]},{"given":"Sonia A.","family":"Melo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"issue":"2","key":"2_CR1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281\u201397.","journal-title":"Cell"},{"issue":"7148","key":"2_CR2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nature05903","volume":"447","author":"A Molnar","year":"2007","unstructured":"Molnar A et al. miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii. Nature. 2007;447(7148):1126\u20139.","journal-title":"Nature"},{"issue":"10","key":"2_CR3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1101\/gad.1543507","volume":"21","author":"T Zhao","year":"2007","unstructured":"Zhao T et al. A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev. 2007;21(10):1190\u2013203.","journal-title":"Genes Dev"},{"issue":"5","key":"2_CR4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843\u201354.","journal-title":"Cell"},{"issue":"6772","key":"2_CR5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","volume":"403","author":"BJ Reinhart","year":"2000","unstructured":"Reinhart BJ et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901\u20136.","journal-title":"Nature"},{"issue":"5543","key":"2_CR6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","volume":"294","author":"M Lagos-Quintana","year":"2001","unstructured":"Lagos-Quintana M et al. Identification of novel genes coding for small expressed RNAs. Science. 2001;294(5543):853\u20138.","journal-title":"Science"},{"issue":"3","key":"2_CR7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.devcel.2005.07.009","volume":"9","author":"AL Abbott","year":"2005","unstructured":"Abbott AL et al. The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell. 2005;9(3):403\u201314.","journal-title":"Dev Cell"},{"issue":"12","key":"2_CR8","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1371\/journal.pgen.0030215","volume":"3","author":"EA Miska","year":"2007","unstructured":"Miska EA et al. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet. 2007;3(12):e215.","journal-title":"PLoS Genet"},{"issue":"5543","key":"2_CR9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1065062","volume":"294","author":"NC Lau","year":"2001","unstructured":"Lau NC et al. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 2001;294(5543):858\u201362.","journal-title":"Science"},{"issue":"9","key":"2_CR10","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin GA et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004;101(9):2999\u20133004.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7043","key":"2_CR11","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","volume":"435","author":"L He","year":"2005","unstructured":"He L et al. A microRNA polycistron as a potential human oncogene. Nature. 2005;435(7043):828\u201333.","journal-title":"Nature"},{"issue":"10A","key":"2_CR12","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1101\/gr.2722704","volume":"14","author":"A Rodriguez","year":"2004","unstructured":"Rodriguez A et al. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004;14(10A):1902\u201310.","journal-title":"Genome Res"},{"issue":"6","key":"2_CR13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.tig.2005.04.008","volume":"21","author":"NR Smalheiser","year":"2005","unstructured":"Smalheiser NR, Torvik VI. Mammalian microRNAs derived from genomic repeats. Trends Genet. 2005;21(6):322\u20136.","journal-title":"Trends Genet"},{"issue":"3","key":"2_CR14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1261\/rna.7240905","volume":"11","author":"S Baskerville","year":"2005","unstructured":"Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA. 2005;11(3):241\u20137.","journal-title":"RNA"},{"issue":"6956","key":"2_CR15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","volume":"425","author":"Y Lee","year":"2003","unstructured":"Lee Y et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003;425(6956):415\u20139.","journal-title":"Nature"},{"issue":"5654","key":"2_CR16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.1090599","volume":"303","author":"E Lund","year":"2004","unstructured":"Lund E et al. Nuclear export of microRNA precursors. Science. 2004;303(5654):95\u20138.","journal-title":"Science"},{"issue":"24","key":"2_CR17","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1101\/gad.1158803","volume":"17","author":"R Yi","year":"2003","unstructured":"Yi R et al. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003;17(24):3011\u20136.","journal-title":"Genes Dev"},{"issue":"22","key":"2_CR18","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1101\/gad.1706508","volume":"22","author":"F Ozsolak","year":"2008","unstructured":"Ozsolak F et al. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008;22(22):3172\u201383.","journal-title":"Genes Dev"},{"issue":"4","key":"2_CR19","doi-asserted-by":"crossref","first-page":"e5279","DOI":"10.1371\/journal.pone.0005279","volume":"4","author":"DL Corcoran","year":"2009","unstructured":"Corcoran DL et al. Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS One. 2009;4(4):e5279.","journal-title":"PLoS One"},{"issue":"4","key":"2_CR20","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","volume":"136","author":"RW Carthew","year":"2009","unstructured":"Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009;136(4):642\u201355.","journal-title":"Cell"},{"issue":"7","key":"2_CR21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/cr.2009.59","volume":"19","author":"W Kim","year":"2009","unstructured":"Kim W et al. Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis. Cell Res. 2009;19(7):899\u2013909.","journal-title":"Cell Res"},{"issue":"12","key":"2_CR22","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1261\/rna.7135204","volume":"10","author":"X Cai","year":"2004","unstructured":"Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA. 2004;10(12):1957\u201366.","journal-title":"RNA"},{"issue":"20","key":"2_CR23","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","volume":"23","author":"Y Lee","year":"2004","unstructured":"Lee Y et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004;23(20):4051\u201360.","journal-title":"EMBO J"},{"issue":"12","key":"2_CR24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nsmb1167","volume":"13","author":"GM Borchert","year":"2006","unstructured":"Borchert GM, Lanier W, Davidson BL. RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 2006;13(12):1097\u2013101.","journal-title":"Nat Struct Mol Biol"},{"issue":"7014","key":"2_CR25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature03049","volume":"432","author":"AM Denli","year":"2004","unstructured":"Denli AM et al. Processing of primary microRNAs by the Microprocessor complex. Nature. 2004;432(7014):231\u20135.","journal-title":"Nature"},{"issue":"7014","key":"2_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature03120","volume":"432","author":"RI Gregory","year":"2004","unstructured":"Gregory RI et al. The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004;432(7014):235\u201340.","journal-title":"Nature"},{"issue":"5","key":"2_CR27","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2006.03.043","volume":"125","author":"J Han","year":"2006","unstructured":"Han J et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell. 2006;125(5):887\u2013901.","journal-title":"Cell"},{"issue":"22","key":"2_CR28","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1093\/nar\/gkg855","volume":"31","author":"E Basyuk","year":"2003","unstructured":"Basyuk E et al. Human let-7 stem-loop precursors harbor features of RNase III cleavage products. Nucleic Acids Res. 2003;31(22):6593\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2_CR29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1357-2725(01)00112-1","volume":"34","author":"C Conrad","year":"2002","unstructured":"Conrad C, Rauhut R. Ribonuclease III: new sense from nuisance. Int J Biochem Cell Biol. 2002;34(2):116\u201329.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"2_CR30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0006-291X(03)00554-0","volume":"304","author":"A Shiohama","year":"2003","unstructured":"Shiohama A et al. Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region. Biochem Biophys Res Commun. 2003;304(1):184\u201390.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5957","key":"2_CR31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1126\/science.1178705","volume":"326","author":"C Okada","year":"2009","unstructured":"Okada C et al. A high-resolution structure of the pre-microRNA nuclear export machinery. Science. 2009;326(5957):1275\u20139.","journal-title":"Science"},{"doi-asserted-by":"crossref","unstructured":"Berezikov E et al. Mammalian mirtron genes. Mol Cell. 2007;28(2):328\u201336.","key":"2_CR32","DOI":"10.1016\/j.molcel.2007.09.028"},{"issue":"1","key":"2_CR33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cell.2007.06.028","volume":"130","author":"K Okamura","year":"2007","unstructured":"Okamura K et al. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell. 2007;130(1):89\u2013100.","journal-title":"Cell"},{"issue":"7149","key":"2_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature05983","volume":"448","author":"JG Ruby","year":"2007","unstructured":"Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing. Nature. 2007;448(7149):83\u20136.","journal-title":"Nature"},{"issue":"20","key":"2_CR35","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1101\/gad.1705308","volume":"22","author":"JE Babiarz","year":"2008","unstructured":"Babiarz JE et al. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev. 2008;22(20):2773\u201385.","journal-title":"Genes Dev"},{"issue":"4","key":"2_CR36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.molcel.2008.10.017","volume":"32","author":"C Ender","year":"2008","unstructured":"Ender C et al. A human snoRNA with microRNA-like functions. Mol Cell. 2008;32(4):519\u201328.","journal-title":"Mol Cell"},{"issue":"11","key":"2_CR37","doi-asserted-by":"crossref","first-page":"e1000224","DOI":"10.1371\/journal.ppat.1000224","volume":"4","author":"AA Saraiya","year":"2008","unstructured":"Saraiya AA, Wang CC. snoRNA, a novel precursor of microRNA in Giardia lamblia. PLoS Pathog. 2008;4(11):e1000224.","journal-title":"PLoS Pathog"},{"issue":"12","key":"2_CR38","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1261\/rna.1738409","volume":"15","author":"C Cole","year":"2009","unstructured":"Cole C et al. Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. RNA. 2009;15(12):2147\u201360.","journal-title":"RNA"},{"issue":"3","key":"2_CR39","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1261\/rna.1952110","volume":"16","author":"K Miyoshi","year":"2010","unstructured":"Miyoshi K et al. Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila. RNA. 2010;16(3):506\u201315.","journal-title":"RNA"},{"issue":"4","key":"2_CR40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tcb.2004.02.006","volume":"14","author":"VN Kim","year":"2004","unstructured":"Kim VN. MicroRNA precursors in motion: exportin-5 mediates their nuclear export. Trends Cell Biol. 2004;14(4):156\u20139.","journal-title":"Trends Cell Biol"},{"issue":"3","key":"2_CR41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ceb.2004.04.003","volume":"16","author":"EP Murchison","year":"2004","unstructured":"Murchison EP, Hannon GJ. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol. 2004;16(3):223\u20139.","journal-title":"Curr Opin Cell Biol"},{"issue":"28","key":"2_CR42","doi-asserted-by":"crossref","first-page":"25910","DOI":"10.1074\/jbc.M100493200","volume":"276","author":"C Gwizdek","year":"2001","unstructured":"Gwizdek C et al. Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. Terminal minihelix and RNA export. J Biol Chem. 2001;276(28):25910\u20138.","journal-title":"J Biol Chem"},{"issue":"4","key":"2_CR43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ccr.2010.09.007","volume":"18","author":"SA Melo","year":"2010","unstructured":"Melo SA et al. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell. 2010;18(4):303\u201315.","journal-title":"Cancer Cell"},{"issue":"6818","key":"2_CR44","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","volume":"409","author":"E Bernstein","year":"2001","unstructured":"Bernstein E et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 2001;409(6818):363\u20136.","journal-title":"Nature"},{"issue":"1","key":"2_CR45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","volume":"106","author":"A Grishok","year":"2001","unstructured":"Grishok A et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106(1):23\u201334.","journal-title":"Cell"},{"issue":"5531","key":"2_CR46","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1062961","volume":"293","author":"G Hutvagner","year":"2001","unstructured":"Hutvagner G et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001;293(5531):834\u20138.","journal-title":"Science"},{"issue":"20","key":"2_CR47","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1101\/gad.927801","volume":"15","author":"RF Ketting","year":"2001","unstructured":"Ketting RF et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 2001;15(20):2654\u20139.","journal-title":"Genes Dev"},{"issue":"5538","key":"2_CR48","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1126\/science.1062039","volume":"293","author":"SW Knight","year":"2001","unstructured":"Knight SW, Bass BL. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science. 2001;293(5538):2269\u201371.","journal-title":"Science"},{"issue":"1","key":"2_CR49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2005.06.023","volume":"122","author":"W. Filipowicz","year":"2005","unstructured":"Filipowicz W. RNAi: the nuts and bolts of the RISC machine. Cell. 2005;122(1):17\u201320.","journal-title":"Cell"},{"issue":"1","key":"2_CR50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cell.2004.06.017","volume":"118","author":"H Zhang","year":"2004","unstructured":"Zhang H et al. Single processing center models for human Dicer and bacterial RNase III. Cell. 2004;118(1):57\u201368.","journal-title":"Cell"},{"issue":"45","key":"2_CR51","doi-asserted-by":"crossref","first-page":"32773","DOI":"10.1074\/jbc.M705054200","volume":"282","author":"DW Salzman","year":"2007","unstructured":"Salzman DW, Shubert-Coleman J, Furneaux H. P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression. J Biol Chem. 2007;282(45):32773\u20139.","journal-title":"J Biol Chem"},{"issue":"2","key":"2_CR52","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(03)00801-8","volume":"115","author":"A Khvorova","year":"2003","unstructured":"Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell. 2003;115(2):209\u201316.","journal-title":"Cell"},{"issue":"2","key":"2_CR53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0092-8674(03)00759-1","volume":"115","author":"DS Schwarz","year":"2003","unstructured":"Schwarz DS et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003;115(2):199\u2013208.","journal-title":"Cell"},{"issue":"3","key":"2_CR54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng.317","volume":"41","author":"SA Melo","year":"2009","unstructured":"Melo SA et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet. 2009;41(3):365\u201370.","journal-title":"Nat Genet"},{"issue":"7051","key":"2_CR55","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature03868","volume":"436","author":"TP Chendrimada","year":"2005","unstructured":"Chendrimada TP et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005;436(7051):740\u20134.","journal-title":"Nature"},{"issue":"10","key":"2_CR56","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/sj.embor.7400509","volume":"6","author":"AD Haase","year":"2005","unstructured":"Haase AD et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 2005;6(10):961\u20137.","journal-title":"EMBO Rep"},{"issue":"7","key":"2_CR57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/ncb0705-643","volume":"7","author":"JJ Rossi","year":"2005","unstructured":"Rossi JJ. RNAi and the P-body connection. Nat Cell Biol. 2005;7(7):643\u20134.","journal-title":"Nat Cell Biol"},{"key":"2_CR58","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2199-10-38","volume":"10","author":"SM Daniels","year":"2009","unstructured":"Daniels SM et al. Characterization of the TRBP domain required for dicer interaction and function in RNA interference. BMC Mol Biol. 2009;10:38.","journal-title":"BMC Mol Biol"},{"issue":"1","key":"2_CR59","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jmb.2008.05.005","volume":"380","author":"E Ma","year":"2008","unstructured":"Ma E et al. Autoinhibition of human dicer by its internal helicase domain. J Mol Biol. 2008;380(1):237\u201343.","journal-title":"J Mol Biol"},{"issue":"4","key":"2_CR60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2005.10.022","volume":"123","author":"RI Gregory","year":"2005","unstructured":"Gregory RI et al. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005;123(4):631\u201340.","journal-title":"Cell"},{"issue":"2","key":"2_CR61","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1073\/pnas.0710869105","volume":"105","author":"IJ MacRae","year":"2008","unstructured":"MacRae IJ et al. In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A. 2008;105(2):512\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2_CR62","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2005.08.044","volume":"123","author":"C Matranga","year":"2005","unstructured":"Matranga C et al. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 2005;123(4):607\u201320.","journal-title":"Cell"},{"issue":"7298","key":"2_CR63","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature09092","volume":"465","author":"S Cheloufi","year":"2010","unstructured":"Cheloufi S et al. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010;465(7298):584\u20139.","journal-title":"Nature"},{"issue":"5986","key":"2_CR64","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1190809","volume":"328","author":"D Cifuentes","year":"2010","unstructured":"Cifuentes D et al. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science. 2010;328(5986):1694\u20138.","journal-title":"Science"},{"issue":"2","key":"2_CR65","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nbt1052","volume":"23","author":"D Siolas","year":"2005","unstructured":"Siolas D et al. Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol. 2005;23(2):227\u201331.","journal-title":"Nat Biotechnol"},{"issue":"Database issue","key":"2_CR66","first-page":"D154","volume":"36","author":"S Griffiths-Jones","year":"2008","unstructured":"Griffiths-Jones S et al. miRBase: tools for microRNA genomics. Nucleic Acids Res. 2008;36(Database issue):D154\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"23","key":"2_CR67","doi-asserted-by":"crossref","first-page":"9667","DOI":"10.1073\/pnas.0703820104","volume":"104","author":"JR Lytle","year":"2007","unstructured":"Lytle JR, Yario TA, Steitz JA. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5\u2032 UTR as in the 3\u2032 UTR. Proc Natl Acad Sci U S A. 2007;104(23):9667\u201372.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"39","key":"2_CR68","doi-asserted-by":"crossref","first-page":"14879","DOI":"10.1073\/pnas.0803230105","volume":"105","author":"JJ Forman","year":"2008","unstructured":"Forman JJ, Legesse-Miller A, Coller HA. A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A. 2008;105(39):14879\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2_CR69","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215\u201333.","journal-title":"Cell"},{"issue":"8","key":"2_CR70","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1158\/0008-5472.CAN-09-0352","volume":"69","author":"I Rigoutsos","year":"2009","unstructured":"Rigoutsos I. New tricks for animal microRNAS: targeting of amino acid coding regions at conserved and nonconserved sites. Cancer Res. 2009;69(8):3245\u20138.","journal-title":"Cancer Res"},{"issue":"11","key":"2_CR71","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/ncb1104-1048","volume":"6","author":"P Jin","year":"2004","unstructured":"Jin P, Alisch RS, Warren ST. RNA and microRNAs in fragile X mental retardation. Nat Cell Biol. 2004;6(11):1048\u201353.","journal-title":"Nat Cell Biol"},{"issue":"2","key":"2_CR72","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1096\/fj.06-6130com","volume":"21","author":"FG Wulczyn","year":"2007","unstructured":"Wulczyn FG et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J. 2007;21(2):415\u201326.","journal-title":"FASEB J"},{"issue":"12","key":"2_CR73","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ncb1334","volume":"7","author":"A Jakymiw","year":"2005","unstructured":"Jakymiw A et al. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol. 2005;7(12):1267\u201374.","journal-title":"Nat Cell Biol"},{"issue":"12","key":"2_CR74","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ncb1333","volume":"7","author":"J Liu","year":"2005","unstructured":"Liu J et al. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005;7(12):1261\u20136.","journal-title":"Nat Cell Biol"},{"issue":"7","key":"2_CR75","doi-asserted-by":"crossref","first-page":"e210","DOI":"10.1371\/journal.pbio.0040210","volume":"4","author":"CY Chu","year":"2006","unstructured":"Chu CY, Rana TM. Translation repression in human cells by microRNA-induced gene silencing requires RCK\/p54. PLoS Biol. 2006;4(7):e210.","journal-title":"PLoS Biol"},{"issue":"20","key":"2_CR76","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1101\/gad.443107","volume":"21","author":"A Eulalio","year":"2007","unstructured":"Eulalio A et al. Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev. 2007;21(20):2558\u201370.","journal-title":"Genes Dev"},{"issue":"7","key":"2_CR77","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","volume":"129","author":"P Landgraf","year":"2007","unstructured":"Landgraf P et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129(7):1401\u201314.","journal-title":"Cell"},{"issue":"Database issue","key":"2_CR78","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkn714","volume":"37","author":"Q Jiang","year":"2009","unstructured":"Jiang Q et al. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res. 2009;37(Database issue):D98\u2013104.","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"2_CR79","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1158\/0008-5472.CAN-06-0537","volume":"66","author":"S Diederichs","year":"2006","unstructured":"Diederichs S, Haber DA. Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing. Cancer Res. 2006;66(12):6097\u2013104.","journal-title":"Cancer Res"},{"issue":"3","key":"2_CR80","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","volume":"9","author":"N Yanaihara","year":"2006","unstructured":"Yanaihara N et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006;9(3):189\u201398.","journal-title":"Cancer Cell"},{"issue":"20","key":"2_CR81","doi-asserted-by":"crossref","first-page":"9762","DOI":"10.1158\/0008-5472.CAN-07-2462","volume":"67","author":"VB Sampson","year":"2007","unstructured":"Sampson VB et al. MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res. 2007;67(20):9762\u201370.","journal-title":"Cancer Res"},{"issue":"5","key":"2_CR82","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2007.05.017","volume":"26","author":"N Raver-Shapira","year":"2007","unstructured":"Raver-Shapira N et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell. 2007;26(5):731\u201343.","journal-title":"Mol Cell"},{"issue":"7148","key":"2_CR83","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature05939","volume":"447","author":"L He","year":"2007","unstructured":"He L et al. A microRNA component of the p53 tumour suppressor network. Nature. 2007;447(7148):1130\u20134.","journal-title":"Nature"},{"issue":"6","key":"2_CR84","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1074\/jbc.M808788200","volume":"284","author":"BN Davis","year":"2009","unstructured":"Davis BN et al. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009;284(6):3728\u201338.","journal-title":"J Biol Chem"},{"issue":"1","key":"2_CR85","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ng.2007.30","volume":"40","author":"TC Chang","year":"2008","unstructured":"Chang TC et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 2008;40(1):43\u201350.","journal-title":"Nat Genet"},{"issue":"13","key":"2_CR86","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1073\/pnas.0600587103","volume":"103","author":"R Garzon","year":"2006","unstructured":"Garzon R et al. MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci U S A. 2006;103(13):5078\u201383.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"2_CR87","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1073\/pnas.0808300106","volume":"106","author":"TC Chang","year":"2009","unstructured":"Chang TC et al. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A. 2009;106(9):3384\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2_CR88","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/emboj.2009.370","volume":"29","author":"MC Chan","year":"2010","unstructured":"Chan MC et al. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010;29(3):559\u201373.","journal-title":"EMBO J."},{"issue":"9","key":"2_CR89","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1073\/pnas.0611192104","volume":"104","author":"M Kato","year":"2007","unstructured":"Kato M et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007;104(9):3432\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"45","key":"2_CR90","doi-asserted-by":"crossref","first-page":"16426","DOI":"10.1073\/pnas.0508448102","volume":"102","author":"N Vo","year":"2005","unstructured":"Vo N et al. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A. 2005;102(45):16426\u201331.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2_CR91","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1158\/0008-5472.CAN-06-4218","volume":"67","author":"A Lujambio","year":"2007","unstructured":"Lujambio A et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 2007;67(4):1424\u20139.","journal-title":"Cancer Res"},{"issue":"36","key":"2_CR92","doi-asserted-by":"crossref","first-page":"13556","DOI":"10.1073\/pnas.0803055105","volume":"105","author":"A Lujambio","year":"2008","unstructured":"Lujambio A et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A. 2008;105(36):13556\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"2_CR93","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1038\/onc.2011.383","volume":"31","author":"V Davalos","year":"2012","unstructured":"Davalos V et al. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene. 2012;31(16):2062\u201374.","journal-title":"Oncogene"},{"issue":"3","key":"2_CR94","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/0008-5472.CAN-05-3632","volume":"66","author":"GK Scott","year":"2006","unstructured":"Scott GK et al. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 2006;66(3):1277\u201381.","journal-title":"Cancer Res"},{"issue":"1","key":"2_CR95","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cell.2008.10.053","volume":"136","author":"J Han","year":"2009","unstructured":"Han J et al. Posttranscriptional crossregulation between Drosha and DGCR8. Cell. 2009;136(1):75\u201384.","journal-title":"Cell"},{"issue":"6","key":"2_CR96","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1261\/rna.1591709","volume":"15","author":"R Triboulet","year":"2009","unstructured":"Triboulet R et al. Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA. 2009;15(6):1005\u201311.","journal-title":"RNA"},{"issue":"7200","key":"2_CR97","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature07086","volume":"454","author":"BN Davis","year":"2008","unstructured":"Davis BN et al. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454(7200):56\u201361.","journal-title":"Nature"},{"issue":"2","key":"2_CR98","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1083\/jcb.201110008","volume":"197","author":"S Kawai","year":"2012","unstructured":"Kawai S, Amano A. BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex. J Cell Biol. 2012;197(2):201\u20138.","journal-title":"J Cell Biol"},{"issue":"1","key":"2_CR99","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2009.06.044","volume":"139","author":"Z Paroo","year":"2009","unstructured":"Paroo Z et al. Phosphorylation of the human microRNA-generating complex mediates MAPK\/Erk signaling. Cell. 2009;139(1):112\u201322.","journal-title":"Cell"},{"issue":"5","key":"2_CR100","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/tpj.2010.9","volume":"10","author":"F Graziano","year":"2010","unstructured":"Graziano F et al. Genetic modulation of the Let-7 microRNA binding to KRAS 3\u2032-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan. Pharmacogenomics J. 2010;10(5):458\u201364.","journal-title":"Pharmacogenomics J"},{"issue":"10","key":"2_CR101","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nsmb.1675","volume":"16","author":"NJ Lehrbach","year":"2009","unstructured":"Lehrbach NJ et al. LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol. 2009;16(10):1016\u201320.","journal-title":"Nat Struct Mol Biol"},{"issue":"10","key":"2_CR102","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nsmb.1676","volume":"16","author":"JP Hagan","year":"2009","unstructured":"Hagan JP, Piskounova E, Gregory RI. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009;16(10):1021\u20135.","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"2_CR103","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","volume":"32","author":"I Heo","year":"2008","unstructured":"Heo I et al. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008;32(2):276\u201384.","journal-title":"Mol Cell"},{"issue":"4","key":"2_CR104","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.cell.2009.08.002","volume":"138","author":"I Heo","year":"2009","unstructured":"Heo I et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell. 2009;138(4):696\u2013708.","journal-title":"Cell"},{"issue":"9","key":"2_CR105","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ncb1931","volume":"11","author":"MR Jones","year":"2009","unstructured":"Jones MR et al. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009;11(9):1157\u201363.","journal-title":"Nat Cell Biol"},{"issue":"7","key":"2_CR106","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.cell.2007.11.034","volume":"131","author":"M Kedde","year":"2007","unstructured":"Kedde M et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell. 2007;131(7):1273\u201386.","journal-title":"Cell"},{"key":"2_CR107","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ncomms1519","volume":"2","author":"N Leveille","year":"2011","unstructured":"Leveille N et al. Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun. 2011;2:513.","journal-title":"Nat Commun"},{"key":"2_CR108","first-page":"91","volume":"353","author":"BE Wulff","year":"2012","unstructured":"Wulff BE, Nishikura K. Modulation of microRNA expression and function by ADARs. Curr Top Microbiol Immunol. 2012;353:91\u2013109.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"3","key":"2_CR109","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrm2347","volume":"9","author":"G Stefani","year":"2008","unstructured":"Stefani G, Slack FJ. Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 2008;9(3):219\u201330.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7014","key":"2_CR110","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","volume":"432","author":"MN Poy","year":"2004","unstructured":"Poy MN et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004;432(7014):226\u201330.","journal-title":"Nature"},{"issue":"5740","key":"2_CR111","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","volume":"309","author":"CL Jopling","year":"2005","unstructured":"Jopling CL et al. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science. 2005;309(5740):1577\u201381.","journal-title":"Science"},{"issue":"39","key":"2_CR112","doi-asserted-by":"crossref","first-page":"15484","DOI":"10.1073\/pnas.0703037104","volume":"104","author":"SJ Greco","year":"2007","unstructured":"Greco SJ, Rameshwar P. MicroRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells. Proc Natl Acad Sci U S A. 2007;104(39):15484\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2_CR113","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/sj.icb.7100091","volume":"85","author":"MP Gantier","year":"2007","unstructured":"Gantier MP, Sadler AJ, Williams BR. Fine-tuning of the innate immune response by microRNAs. Immunol Cell Biol. 2007;85(6):458\u201362.","journal-title":"Immunol Cell Biol"},{"issue":"1","key":"2_CR114","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(03)00231-9","volume":"113","author":"J Brennecke","year":"2003","unstructured":"Brennecke J et al. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 2003;113(1):25\u201336.","journal-title":"Cell"},{"issue":"7216","key":"2_CR115","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nature07299","volume":"455","author":"Y Tay","year":"2008","unstructured":"Tay Y et al. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature. 2008;455(7216):1124\u20138.","journal-title":"Nature"},{"issue":"7044","key":"2_CR116","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/nature03816","volume":"435","author":"SD Hatfield","year":"2005","unstructured":"Hatfield SD et al. Stem cell division is regulated by the microRNA pathway. Nature. 2005;435(7044):974\u20138.","journal-title":"Nature"},{"issue":"7068","key":"2_CR117","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature04138","volume":"438","author":"E Hornstein","year":"2005","unstructured":"Hornstein E et al. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature. 2005;438(7068):671\u20134.","journal-title":"Nature"},{"issue":"7074","key":"2_CR118","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","volume":"439","author":"GM Schratt","year":"2006","unstructured":"Schratt GM et al. A brain-specific microRNA regulates dendritic spine development. Nature. 2006;439(7074):283\u20139.","journal-title":"Nature"},{"issue":"52","key":"2_CR119","doi-asserted-by":"crossref","first-page":"18986","DOI":"10.1073\/pnas.0509535102","volume":"102","author":"C Kwon","year":"2005","unstructured":"Kwon C et al. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A. 2005;102(52):18986\u201391.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5824","key":"2_CR120","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","volume":"316","author":"A Rodriguez","year":"2007","unstructured":"Rodriguez A et al. Requirement of bic\/microRNA-155 for normal immune function. Science. 2007;316(5824):608\u201311.","journal-title":"Science"},{"issue":"1","key":"2_CR121","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","volume":"131","author":"C Xiao","year":"2007","unstructured":"Xiao C et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007;131(1):146\u201359.","journal-title":"Cell"},{"issue":"17","key":"2_CR122","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","volume":"105","author":"SS Hebert","year":"2008","unstructured":"Hebert SS et al. Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/beta-secretase expression. Proc Natl Acad Sci U S A. 2008;105(17):6415\u201320.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5842","key":"2_CR123","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1140481","volume":"317","author":"J Kim","year":"2007","unstructured":"Kim J et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 2007;317(5842):1220\u20134.","journal-title":"Science"},{"issue":"5","key":"2_CR124","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","volume":"13","author":"A Care","year":"2007","unstructured":"Care A et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13(5):613\u20138.","journal-title":"Nat Med"},{"issue":"5","key":"2_CR125","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/ng.355","volume":"41","author":"A Mencia","year":"2009","unstructured":"Mencia A et al. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet. 2009;41(5):609\u201313.","journal-title":"Nat Genet"},{"issue":"5","key":"2_CR126","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2006.02.030","volume":"124","author":"RH Plasterk","year":"2006","unstructured":"Plasterk RH. Micro RNAs in animal development. Cell. 2006;124(5):877\u201381.","journal-title":"Cell"},{"issue":"4","key":"2_CR127","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.cell.2009.02.005","volume":"136","author":"A Ventura","year":"2009","unstructured":"Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell. 2009;136(4):586\u201391.","journal-title":"Cell"},{"issue":"5","key":"2_CR128","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.cell.2008.02.020","volume":"132","author":"SB Koralov","year":"2008","unstructured":"Koralov SB et al. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008;132(5):860\u201374.","journal-title":"Cell"},{"issue":"6","key":"2_CR129","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4161\/cc.7.6.5834","volume":"7","author":"A Esquela-Kerscher","year":"2008","unstructured":"Esquela-Kerscher A et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle. 2008;7(6):759\u201364.","journal-title":"Cell Cycle"},{"issue":"10","key":"2_CR130","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0712321105","volume":"105","author":"MS Kumar","year":"2008","unstructured":"Kumar MS et al. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A. 2008;105(10):3903\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2_CR131","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1261\/rna.1155108","volume":"14","author":"MA Newman","year":"2008","unstructured":"Newman MA, Thomson JM, Hammond SM. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA. 2008;14(8):1539\u201349.","journal-title":"RNA"},{"issue":"5872","key":"2_CR132","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","volume":"320","author":"SR Viswanathan","year":"2008","unstructured":"Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science. 2008;320(5872):97\u2013100.","journal-title":"Science"},{"issue":"5818","key":"2_CR133","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","volume":"315","author":"C Mayr","year":"2007","unstructured":"Mayr C, Hemann MT, Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science. 2007;315(5818):1576\u20139.","journal-title":"Science"},{"issue":"6","key":"2_CR134","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.cell.2006.02.037","volume":"124","author":"PM Voorhoeve","year":"2006","unstructured":"Voorhoeve PM et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell. 2006;124(6):1169\u201381.","journal-title":"Cell"},{"issue":"7043","key":"2_CR135","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu J et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435(7043):834\u20138.","journal-title":"Nature"},{"issue":"16","key":"2_CR136","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1101\/gad.1444406","volume":"20","author":"JM Thomson","year":"2006","unstructured":"Thomson JM et al. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20(16):2202\u20137.","journal-title":"Genes Dev"},{"issue":"5","key":"2_CR137","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ng2003","volume":"39","author":"MS Kumar","year":"2007","unstructured":"Kumar MS et al. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet. 2007;39(5):673\u20137.","journal-title":"Nat Genet"},{"issue":"2","key":"2_CR138","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/path.2683","volume":"221","author":"MS Kim","year":"2010","unstructured":"Kim MS et al. Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. J Pathol. 2010;221(2):139\u201346.","journal-title":"J Pathol"},{"issue":"3","key":"2_CR139","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1056\/NEJMoa1102903","volume":"366","author":"A Heravi-Moussavi","year":"2012","unstructured":"Heravi-Moussavi A et al. Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. N Engl J Med. 2012;366(3):234\u201342.","journal-title":"N Engl J Med"},{"issue":"23","key":"2_CR140","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1101\/gad.1848209","volume":"23","author":"MS Kumar","year":"2009","unstructured":"Kumar MS et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009;23(23):2700\u20134.","journal-title":"Genes Dev"},{"issue":"6808","key":"2_CR141","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","volume":"408","author":"AE Pasquinelli","year":"2000","unstructured":"Pasquinelli AE et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86\u20139.","journal-title":"Nature."}],"container-title":["Non-coding RNAs and Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4614-8444-8_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T20:38:29Z","timestamp":1558643909000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4614-8444-8_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,8]]},"ISBN":["9781461484431","9781461484448"],"references-count":141,"URL":"https:\/\/doi.org\/10.1007\/978-1-4614-8444-8_2","relation":{},"subject":[],"published":{"date-parts":[[2013,10,8]]}}}