{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T06:09:33Z","timestamp":1743055773321,"version":"3.40.3"},"publisher-location":"Totowa, NJ","reference-count":99,"publisher":"Humana Press","isbn-type":[{"type":"print","value":"9781627030762"},{"type":"electronic","value":"9781627030779"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-1-62703-077-9_20","type":"book-chapter","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T19:46:51Z","timestamp":1348084011000},"page":"397-409","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Animal Models of Cystitis"],"prefix":"10.1007","author":[{"given":"C\u00e9lia D.","family":"Cruz","sequence":"first","affiliation":[]},{"given":"Ant\u00f3nio","family":"Avelino","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,8,2]]},"reference":[{"key":"20_CR1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/nau.21131","volume":"30","author":"CH Fry","year":"2011","unstructured":"Fry CH, Sadananda P, Wood DN, Thiruchelvam N, Jabr RI, Clayton R (2011) Modeling the urinary tract-computational, physical, and biological methods. Neurourol Urodyn 30:692\u2013699","journal-title":"Neurourol Urodyn"},{"key":"20_CR2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/nau.20903","volume":"29","author":"CH Fry","year":"2010","unstructured":"Fry CH, Daneshgari F, Thor K et al (2010) Animal models and their use in understanding lower urinary tract dysfunction. Neurourol Urodyn 29:603\u2013608","journal-title":"Neurourol Urodyn"},{"key":"20_CR3","first-page":"197","volume-title":"Principles of laboratory animal science: a contribution to the humane use and care of animals and to the quality of experimental results","author":"AC Beynen","year":"2001","unstructured":"Beynen AC, Hau J (2001) Animal models. In: Van Zuthphen LFM, Baumans V, Beynen AC (eds) Principles of laboratory animal science: a contribution to the humane use and care of animals and to the quality of experimental results. Elsevier, Amesterdam, pp 197\u2013205"},{"key":"20_CR4","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/S0278-5846(00)00139-1","volume":"24","author":"SJ Bird","year":"2000","unstructured":"Bird SJ, Parlee MB (2000) Of mice and men (and women and children): scientific and ethical implications of animal models. Prog Neuropsychopharmacol Biol Psychiatry 24: 1219\u20131227","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"20_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1744-9081-5-11","volume":"5","author":"FJ van der Staay","year":"2009","unstructured":"van der Staay FJ, Arndt SS, Nordquist RE (2009) Evaluation of animal models of neurobehavioral disorders. Behav Brain Funct 5:11","journal-title":"Behav Brain Funct"},{"issue":"Suppl 2","key":"20_CR6","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1038\/sj.bjp.0706630","volume":"147","author":"G McMurray","year":"2006","unstructured":"McMurray G, Casey JH, Naylor AM (2006) Animal models in urological disease and sexual dysfunction. Br J Pharmacol 147(Suppl 2): S62\u2013S79","journal-title":"Br J Pharmacol"},{"key":"20_CR7","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/nau.21108","volume":"30","author":"KE Andersson","year":"2011","unstructured":"Andersson KE, Soler R, Fullhase C (2011) Rodent models for urodynamic investigation. Neurourol Urodyn 30:636\u2013646","journal-title":"Neurourol Urodyn"},{"key":"20_CR8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1476-5381.1990.tb12956.x","volume":"99","author":"AF Brading","year":"1990","unstructured":"Brading AF, Williams JH (1990) Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: effects of atropine and alpha, beta-methylene ATP. Br J Pharmacol 99:493\u2013498","journal-title":"Br J Pharmacol"},{"key":"20_CR9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/j.1476-5381.1990.tb15856.x","volume":"100","author":"R Inoue","year":"1990","unstructured":"Inoue R, Brading AF (1990) The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol 100:619\u2013625","journal-title":"Br J Pharmacol"},{"key":"20_CR10","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1152\/physrev.00038.2003","volume":"84","author":"KE Andersson","year":"2004","unstructured":"Andersson KE, Arner A (2004) Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84:935\u2013986","journal-title":"Physiol Rev"},{"key":"20_CR11","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1097\/00001756-199511000-00027","volume":"6","author":"B Uvelius","year":"1995","unstructured":"Uvelius B, Gabella G (1995) Intramural neurones appear in the urinary bladder wall following excision of the pelvic ganglion in the rat. Neuroreport 6:2213\u20132216","journal-title":"Neuroreport"},{"key":"20_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.autneu.2008.04.001","volume":"140","author":"LL Cornelissen","year":"2008","unstructured":"Cornelissen LL, Misajet B, Brooks DP, Hicks A (2008) Influence of genetic background and gender on bladder function in the mouse. Auton Neurosci 140:53\u201358","journal-title":"Auton Neurosci"},{"key":"20_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.mcna.2010.08.014","volume":"95","author":"P Hanno","year":"2010","unstructured":"Hanno P, Nordling J, Fall M (2010) Bladder pain syndrome. Med Clin North Am 95:55\u201373","journal-title":"Med Clin North Am"},{"key":"20_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00345-009-0439-4","volume":"27","author":"PM Hanno","year":"2009","unstructured":"Hanno PM, Chapple CR, Cardozo LD (2009) Bladder pain syndrome\/interstitial cystitis: a sense of urgency. World J Urol 27:5","journal-title":"World J Urol"},{"key":"20_CR15","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/01.ju.0000165452.39125.98","volume":"174","author":"M Leppilahti","year":"2005","unstructured":"Leppilahti M, Sairanen J, Tammela TL, Aaltomaa S, Lehtoranta K, Auvinen A (2005) Prevalence of clinically confirmed interstitial cystitis in women: a population based study in Finland. J Urol 174:581\u2013583","journal-title":"J Urol"},{"key":"20_CR16","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.eururo.2006.08.028","volume":"51","author":"C Temml","year":"2007","unstructured":"Temml C, Wehrberger C, Riedl C, Ponholzer A, Marszalek M, Madersbacher S (2007) Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project. Eur Urol 51:803\u2013808, \u00addiscussion 9","journal-title":"Eur Urol"},{"key":"20_CR17","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/nau.21078","volume":"30","author":"DE Bjorling","year":"2011","unstructured":"Bjorling DE, Wang ZY, Bushman W (2011) Models of inflammation of the lower urinary tract. Neurourol Urodyn 30:673\u2013682","journal-title":"Neurourol Urodyn"},{"key":"20_CR18","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0022-5347(17)37091-X","volume":"148","author":"AD Bullock","year":"1992","unstructured":"Bullock AD, Becich MJ, Klutke CG, Ratliff TL (1992) Experimental autoimmune cystitis: a potential murine model for ulcerative interstitial cystitis. J Urol 148:1951\u20131956","journal-title":"J Urol"},{"key":"20_CR19","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1464-410X.2007.07035.x","volume":"100","author":"H Phull","year":"2007","unstructured":"Phull H, Salkini M, Purves T, Funk J, Copeland D, Comiter CV (2007) Angiotensin II plays a role in acute murine experimental autoimmune cystitis. BJU Int 100:664\u2013667","journal-title":"BJU Int"},{"key":"20_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00389795","volume":"24","author":"J Luber-Narod","year":"1996","unstructured":"Luber-Narod J, Austin-Ritchie T, Banner B et al (1996) Experimental autoimmune cystitis in the Lewis rat: a potential animal model for interstitial cystitis. Urol Res 24:367\u2013373","journal-title":"Urol Res"},{"key":"20_CR21","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s002400050162","volume":"27","author":"S Mitra","year":"1999","unstructured":"Mitra S, Dagher A, Kage R, Dagher RK, Luber-Narod J (1999) Experimental autoimmune cystitis: further characterization and serum autoantibodies. Urol Res 27:351\u2013356","journal-title":"Urol Res"},{"key":"20_CR22","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2460\/javma.1999.215.05.682","volume":"215","author":"CA Buffington","year":"1999","unstructured":"Buffington CA, Chew DJ, Woodworth BE (1999) Feline interstitial cystitis. J Am Vet Med Assoc 215:682\u2013687","journal-title":"J Am Vet Med Assoc"},{"key":"20_CR23","doi-asserted-by":"crossref","first-page":"F540","DOI":"10.1152\/ajprenal.2000.278.4.F540","volume":"278","author":"JP Lavelle","year":"2000","unstructured":"Lavelle JP, Meyers SA, Ruiz WG, Buffington CA, Zeidel ML, Apodaca G (2000) Urothelial pathophysiological changes in feline interstitial cystitis: a human model. Am J Physiol Renal Physiol 278:F540\u2013F553","journal-title":"Am J Physiol Renal Physiol"},{"key":"20_CR24","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/S0022-5347(01)66201-3","volume":"155","author":"CA Buffington","year":"1996","unstructured":"Buffington CA, Blaisdell JL, Binns SP Jr, Woodworth BE (1996) Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis. J Urol 155:1801\u20131804","journal-title":"J Urol"},{"key":"20_CR25","doi-asserted-by":"publisher","first-page":"F1084","DOI":"10.1152\/ajprenal.00118.2004","volume":"287","author":"LA Birder","year":"2004","unstructured":"Birder LA, Ruan HZ, Chopra B et al (2004) Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 287:F1084\u2013F1091","journal-title":"Am J Physiol Renal Physiol"},{"key":"20_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/nau.20747","volume":"29","author":"LA Birder","year":"2010","unstructured":"Birder LA, Wolf-Johnston AS, Chib MK, Buffington CA, Roppolo JR, Hanna-Mitchell AT (2010) Beyond neurons: involvement of urothelial and glial cells in bladder function. Neurourol Urodyn 29:88\u201396","journal-title":"Neurourol Urodyn"},{"key":"20_CR27","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/S0022-5347(01)69129-8","volume":"167","author":"JL Westropp","year":"2002","unstructured":"Westropp JL, Buffington CA (2002) In vivo models of interstitial cystitis. J Urol 167:694\u2013702","journal-title":"J Urol"},{"key":"20_CR28","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/ncpuro0874","volume":"4","author":"JP van de Merwe","year":"2007","unstructured":"van de Merwe JP (2007) Interstitial cystitis and systemic autoimmune diseases. Nat Clin Pract Urol 4:484\u2013491","journal-title":"Nat Clin Pract Urol"},{"key":"20_CR29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0272-2712(18)30211-7","volume":"17","author":"RL Ochs","year":"1997","unstructured":"Ochs RL (1997) Autoantibodies and interstitial cystitis. Clin Lab Med 17:571\u2013579","journal-title":"Clin Lab Med"},{"key":"20_CR30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0022-5347(17)37211-7","volume":"147","author":"YS Kim","year":"1992","unstructured":"Kim YS, Levin RM, Wein AJ, Longhurst PA (1992) Effects of sensitization on the permeability of urothelium in guinea pig urinary bladder. J Urol 147:270\u2013273","journal-title":"J Urol"},{"key":"20_CR31","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0022-5347(17)37823-0","volume":"146","author":"YS Kim","year":"1991","unstructured":"Kim YS, Longhurst PA, Wein AJ, Levin RM (1991) Effects of sensitization on female guinea pig urinary bladder function: in vivo and in vitro studies. J Urol 146:454\u2013457","journal-title":"J Urol"},{"key":"20_CR32","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0022-5347(01)67034-4","volume":"154","author":"JG Lee","year":"1995","unstructured":"Lee JG, Levin RM, Krasnopolsky L, Wein AJ, Longhurst PA (1995) Effects of the peptide leukotriene receptor antagonist ICI 198,615 on the in vivo and in vitro changes in guinea pig bladder function which occur after sensitization with ovalbumin. J Urol 154:1217\u20131221","journal-title":"J Urol"},{"key":"20_CR33","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0022-5347(17)39722-7","volume":"144","author":"MM Christensen","year":"1990","unstructured":"Christensen MM, Keith I, Rhodes PR et al (1990) A guinea pig model for study of bladder mast cell function: histamine release and smooth muscle contraction. J Urol 144:1293\u20131300","journal-title":"J Urol"},{"key":"20_CR34","first-page":"F205","volume":"274","author":"JP Lavelle","year":"1998","unstructured":"Lavelle JP, Apodaca G, Meyers SA, Ruiz WG, Zeidel ML (1998) Disruption of guinea pig urinary bladder permeability barrier in noninfectious cystitis. Am J Physiol 274:F205\u2013F214","journal-title":"Am J Physiol"},{"key":"20_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1155\/S0962935194000268","volume":"3","author":"DE Bjorling","year":"1994","unstructured":"Bjorling DE, Saban MR, Saban R (1994) Neurogenic inflammation of Guinea-pig bladder. Mediators Inflamm 3:189\u2013197","journal-title":"Mediators Inflamm"},{"key":"20_CR36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1152\/physiolgenomics.00044.2001","volume":"7","author":"R Saban","year":"2001","unstructured":"Saban R, Saban MR, Nguyen NB, Hammond TG, Wershil BK (2001) Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice. Physiol Genomics 7:35\u201343","journal-title":"Physiol Genomics"},{"key":"20_CR37","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0002-9440(10)64944-9","volume":"156","author":"R Saban","year":"2000","unstructured":"Saban R, Saban MR, Nguyen NB et al (2000) Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Am J Pathol 156:775\u2013780","journal-title":"Am J Pathol"},{"key":"20_CR38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physiolgenomics.00141.2002","volume":"12","author":"I Dozmorov","year":"2003","unstructured":"Dozmorov I, Saban MR, Gerard NP et al (2003) Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation. Physiol Genomics 12:239\u2013250","journal-title":"Physiol Genomics"},{"key":"20_CR39","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/S0002-9440(10)61159-5","volume":"160","author":"MR Saban","year":"2002","unstructured":"Saban MR, Nguyen NB, Hammond TG, Saban R (2002) Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. Am J Pathol 160:2095\u20132110","journal-title":"Am J Pathol"},{"key":"20_CR40","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0165-0270(00)00295-8","volume":"103","author":"G Aston-Jones","year":"2000","unstructured":"Aston-Jones G, Card JP (2000) Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations. J Neurosci Methods 103:51\u201361","journal-title":"J Neurosci Methods"},{"key":"20_CR41","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/S0306-4522(96)00384-3","volume":"76","author":"L Jasmin","year":"1997","unstructured":"Jasmin L, Carstens E, Basbaum AI (1997) Interneurons presynaptic to rat tail-flick motoneurons as mapped by transneuronal transport of pseudorabies virus: few have long ascending collaterals. Neuroscience 76:859\u2013876","journal-title":"Neuroscience"},{"key":"20_CR42","doi-asserted-by":"crossref","first-page":"10016","DOI":"10.1523\/JNEUROSCI.18-23-10016.1998","volume":"18","author":"L Jasmin","year":"1998","unstructured":"Jasmin L, Janni G, Manz HJ, Rabkin SD (1998) Activation of CNS circuits producing a neurogenic cystitis: evidence for centrally induced peripheral inflammation. J Neurosci 18:10016\u201310029","journal-title":"J Neurosci"},{"key":"20_CR43","doi-asserted-by":"publisher","first-page":"e2096","DOI":"10.1371\/journal.pone.0002096","volume":"3","author":"CN Rudick","year":"2008","unstructured":"Rudick CN, Bryce PJ, Guichelaar LA, Berry RE, Klumpp DJ (2008) Mast cell-derived histamine mediates cystitis pain. PLoS One 3:e2096","journal-title":"PLoS One"},{"key":"20_CR44","doi-asserted-by":"publisher","first-page":"R1191","DOI":"10.1152\/ajpregu.00411.2007","volume":"293","author":"CN Rudick","year":"2007","unstructured":"Rudick CN, Chen MC, Mongiu AK, Klumpp DJ (2007) Organ cross talk modulates pelvic pain. Am J Physiol Regul Integr Comp Physiol 293:R1191\u2013R1198","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"20_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2490-9-16","volume":"9","author":"CN Rudick","year":"2009","unstructured":"Rudick CN, Schaeffer AJ, Klumpp DJ (2009) Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. BMC Urol 9:16","journal-title":"BMC Urol"},{"key":"20_CR46","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/S0022-5347(05)67326-0","volume":"164","author":"L Jasmin","year":"2000","unstructured":"Jasmin L, Janni G, Ohara PT, Rabkin SD (2000) CNS induced neurogenic cystitis is associated with bladder mast cell degranulation in the rat. J Urol 164:852\u2013855","journal-title":"J Urol"},{"key":"20_CR47","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/S0022-5347(01)62611-9","volume":"160","author":"R Doggweiler","year":"1998","unstructured":"Doggweiler R, Jasmin L, Schmidt RA (1998) Neurogenically mediated cystitis in rats: an animal model. J Urol 160:1551\u20131556","journal-title":"J Urol"},{"key":"20_CR48","first-page":"116","volume":"8","author":"GW Locher","year":"1970","unstructured":"Locher GW, Cooper EH (1970) Repair of rat urinary bladder epithelium following injury by cyclophosphamide. Invest Urol 8:116\u2013123","journal-title":"Invest Urol"},{"key":"20_CR49","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1097\/01.ju.0000079766.49550.94","volume":"170","author":"K Bon","year":"2003","unstructured":"Bon K, Lichtensteiger CA, Wilson SG, Mogil JS (2003) Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences. J Urol 170:1008\u20131012","journal-title":"J Urol"},{"key":"20_CR50","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1097\/01.ju.0000155170.15023.e5","volume":"173","author":"VY Hu","year":"2005","unstructured":"Hu VY, Zvara P, Dattilio A et al (2005) Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis. J Urol 173:1016\u20131021","journal-title":"J Urol"},{"key":"20_CR51","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/cne.10447","volume":"454","author":"LY Qiao","year":"2002","unstructured":"Qiao LY, Vizzard MA (2002) Cystitis-induced upregulation of tyrosine kinase (TrkA, TrkB) receptor expression and phosphorylation in rat micturition pathways. J Comp Neurol 454:200\u2013211","journal-title":"J Comp Neurol"},{"key":"20_CR52","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/exnr.1999.7254","volume":"161","author":"MA Vizzard","year":"2000","unstructured":"Vizzard MA (2000) Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol 161:273\u2013284","journal-title":"Exp Neurol"},{"key":"20_CR53","doi-asserted-by":"publisher","first-page":"11253","DOI":"10.1523\/JNEUROSCI.2657-04.2004","volume":"24","author":"P Dinis","year":"2004","unstructured":"Dinis P, Charrua A, Avelino A et al (2004) Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosci 24:11253\u201311263","journal-title":"J Neurosci"},{"key":"20_CR54","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.neuroscience.2010.01.015","volume":"166","author":"R Pinto","year":"2010","unstructured":"Pinto R, Frias B, Allen S et al (2010) Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces \u00adbladder overactivity and noxious input in \u00adanimals with chronic cystitis. Neuroscience 166:907\u2013916","journal-title":"Neuroscience"},{"key":"20_CR55","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S0022-5347(05)66152-6","volume":"166","author":"M Meen","year":"2001","unstructured":"Meen M, Coudore-Civiale MA, Eschalier A, Boucher M (2001) Involvement of hypogastric and pelvic nerves for conveying cystitis induced nociception in conscious rats. J Urol 166:318\u2013322","journal-title":"J Urol"},{"key":"20_CR56","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1053\/eujp.2002.0340","volume":"6","author":"M Meen","year":"2002","unstructured":"Meen M, Coudore-Civiale MA, Parry L, Eschalier A, Boucher M (2002) Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat. Eur J Pain 6:307\u2013314","journal-title":"Eur J Pain"},{"key":"20_CR57","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1464-4096.2004.04855.x","volume":"94","author":"P Dinis","year":"2004","unstructured":"Dinis P, Charrua A, Avelino A, Cruz F (2004) Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders. BJU Int 94:153\u2013157","journal-title":"BJU Int"},{"key":"20_CR58","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1460-9568.2005.03893.x","volume":"21","author":"CD Cruz","year":"2005","unstructured":"Cruz CD, Avelino A, McMahon SB, Cruz F (2005) Increased spinal cord phosphorylation of extracellular signal-regulated kinases mediates micturition overactivity in rats with chronic bladder inflammation. Eur J Neurosci 21:773\u2013781","journal-title":"Eur J Neurosci"},{"key":"20_CR59","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.4049\/jimmunol.165.10.5780","volume":"165","author":"RI Tapping","year":"2000","unstructured":"Tapping RI, Akashi S, Miyake K, Godowski PJ, Tobias PS (2000) Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol 165:5780\u20135787","journal-title":"J Immunol"},{"key":"20_CR60","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1046\/j.1464-410x.2001.02138.x","volume":"87","author":"DE Bjorling","year":"2001","unstructured":"Bjorling DE, Jacobsen HE, Blum JR et al (2001) Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor. BJU Int 87:697\u2013702","journal-title":"BJU Int"},{"key":"20_CR61","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1089\/107999004772719918","volume":"24","author":"KL Meyer-Siegler","year":"2004","unstructured":"Meyer-Siegler KL, Ordorica RC, Vera PL (2004) Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. J Interferon Cytokine Res 24:55\u201363","journal-title":"J Interferon Cytokine Res"},{"key":"20_CR62","doi-asserted-by":"crossref","first-page":"F202","DOI":"10.1152\/ajprenal.0163.2001","volume":"282","author":"MR Saban","year":"2002","unstructured":"Saban MR, Saban R, Hammond TG et al (2002) LPS-sensory peptide communication in experimental cystitis. Am J Physiol Renal Physiol 282:F202\u2013F210","journal-title":"Am J Physiol Renal Physiol"},{"key":"20_CR63","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1472-6793-7-3","volume":"7","author":"R Saban","year":"2007","unstructured":"Saban R, D\u2019Andrea MR, Andrade-Gordon P et al (2007) Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol 7:3","journal-title":"BMC Physiol"},{"key":"20_CR64","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.juro.2006.11.046","volume":"177","author":"A Charrua","year":"2007","unstructured":"Charrua A, Cruz CD, Cruz F, Avelino A (2007) Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis. J Urol 177:1537\u20131541","journal-title":"J Urol"},{"key":"20_CR65","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2172-9-4","volume":"9","author":"MR Saban","year":"2008","unstructured":"Saban MR, O\u2019Donnell MA, Hurst RE et al (2008) Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. BMC Immunol 9:4","journal-title":"BMC Immunol"},{"key":"20_CR66","doi-asserted-by":"publisher","first-page":"F1245","DOI":"10.1152\/ajprenal.00352.2010","volume":"299","author":"MR Saban","year":"2011","unstructured":"Saban MR, Sferra TJ, Davis CA et al (2011) Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment. Am J Physiol Renal Physiol 299:F1245\u2013F1256","journal-title":"Am J Physiol Renal Physiol"},{"key":"20_CR67","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2172-8-6","volume":"8","author":"MR Saban","year":"2007","unstructured":"Saban MR, Simpson C, Davis C et al (2007) Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG). BMC Immunol 8:6","journal-title":"BMC Immunol"},{"key":"20_CR68","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(87)91065-7","volume":"28","author":"SB McMahon","year":"1987","unstructured":"McMahon SB, Abel C (1987) A model for the study of visceral pain states: chronic inflammation of the chronic decerebrate rat urinary bladder by irritant chemicals. Pain 28:109\u2013127","journal-title":"Pain"},{"key":"20_CR69","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/BF01965016","volume":"25","author":"HJ Habler","year":"1988","unstructured":"Habler HJ, Janig W, Koltzenburg M (1988) A novel type of unmyelinated chemosensitive nociceptor in the acutely inflamed urinary bladder. Agents Actions 25:219\u2013221","journal-title":"Agents Actions"},{"key":"20_CR70","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/BF01965020","volume":"25","author":"SB McMahon","year":"1988","unstructured":"McMahon SB (1988) Neuronal and behavioural consequences of chemical inflammation of rat urinary bladder. Agents Actions 25:231\u2013233","journal-title":"Agents Actions"},{"key":"20_CR71","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0304-3959(97)00217-0","volume":"75","author":"SI Jaggar","year":"1998","unstructured":"Jaggar SI, Habib S, Rice AS (1998) The modulatory effects of bradykinin B1 and B2 receptor antagonists upon viscero-visceral hyper-reflexia in a rat model of visceral hyperalgesia. Pain 75:169\u2013176","journal-title":"Pain"},{"key":"20_CR72","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1093\/bja\/83.3.442","volume":"83","author":"SI Jaggar","year":"1999","unstructured":"Jaggar SI, Scott HC, Rice AS (1999) Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent. Br J Anaesth 83:442\u2013448","journal-title":"Br J Anaesth"},{"key":"20_CR73","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0304-3940(95)11356-8","volume":"187","author":"AS Rice","year":"1995","unstructured":"Rice AS (1995) Topical spinal administration of a nitric oxide synthase inhibitor prevents the hyper-reflexia associated with a rat model of persistent visceral pain. Neurosci Lett 187: 111\u2013114","journal-title":"Neurosci Lett"},{"key":"20_CR74","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1152\/jn.1993.69.2.395","volume":"69","author":"HJ Habler","year":"1993","unstructured":"Habler HJ, Janig W, Koltzenburg M (1993) Receptive properties of myelinated primary afferents innervating the inflamed urinary bladder of the cat. J Neurophysiol 69: 395\u2013405","journal-title":"J Neurophysiol"},{"key":"20_CR75","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0165-1838(97)00032-5","volume":"65","author":"P Callsen-Cencic","year":"1997","unstructured":"Callsen-Cencic P, Mense S (1997) Expression of neuropeptides and nitric oxide synthase in neurones innervating the inflamed rat urinary bladder. J Auton Nerv Syst 65:33\u201344","journal-title":"J Auton Nerv Syst"},{"key":"20_CR76","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jpain.2009.07.010","volume":"11","author":"J DeBerry","year":"2010","unstructured":"DeBerry J, Randich A, Shaffer AD, Robbins MT, Ness TJ (2010) Neonatal bladder inflammation produces functional changes and alters neuropeptide content in bladders of adult female rats. J Pain 11:247\u2013255","journal-title":"J Pain"},{"key":"20_CR77","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1523\/JNEUROSCI.12-12-04878.1992","volume":"12","author":"LA Birder","year":"1992","unstructured":"Birder LA, de Groat WC (1992) Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat. J Neurosci 12:4878\u20134889","journal-title":"J Neurosci"},{"key":"20_CR78","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S0090-4295(02)02281-1","volume":"61","author":"MO Fraser","year":"2003","unstructured":"Fraser MO, Chuang YC, Tyagi P et al (2003) Intravesical liposome administration \u2013 a novel treatment for hyperactive bladder in the rat. Urology 61:656\u2013663","journal-title":"Urology"},{"key":"20_CR79","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nn902","volume":"5","author":"LA Birder","year":"2002","unstructured":"Birder LA, Nakamura Y, Kiss S et al (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5:856\u2013860","journal-title":"Nat Neurosci"},{"key":"20_CR80","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.juro.2008.08.121","volume":"181","author":"A Charrua","year":"2009","unstructured":"Charrua A, Cruz CD, Narayanan S et al (2009) GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol 181:379\u2013386","journal-title":"J Urol"},{"key":"20_CR81","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/S0022-5347(01)64905-X","volume":"157","author":"DA Rivas","year":"1997","unstructured":"Rivas DA, Chancellor MB, Shupp-Byrne S, Shenot PJ, McHugh K, McCue P (1997) Molecular marker for development of interstitial cystitis in rat model: isoactin gene expression. J Urol 157:1937\u20131940","journal-title":"J Urol"},{"key":"20_CR82","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1046\/j.1464-410x.2000.00873.x","volume":"86","author":"Y Wang","year":"2000","unstructured":"Wang Y, Zhou Y, Mourad MS, Hassouna MM (2000) Neuromodulation reduces urinary frequency in rats with hydrochloric acid-induced cystitis. BJU Int 86:726\u2013730","journal-title":"BJU Int"},{"key":"20_CR83","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1016\/0006-2952(79)90222-3","volume":"28","author":"PJ Cox","year":"1979","unstructured":"Cox PJ (1979) Cyclophosphamide cystitis \u2013 identification of acrolein as the causative agent. Biochem Pharmacol 28:2045\u20132049","journal-title":"Biochem Pharmacol"},{"key":"20_CR84","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-5347(17)36545-X","volume":"148","author":"SJ Kalota","year":"1992","unstructured":"Kalota SJ, Stein PC, Parsons CL (1992) Prevention of acrolein-induced bladder injury by pentosanpolysulfate. J Urol 148:163\u2013166","journal-title":"J Urol"},{"key":"20_CR85","first-page":"159","volume":"9","author":"T Sakata","year":"1989","unstructured":"Sakata T, Smith RA, Garland EM, Cohen SM (1989) Rat urinary bladder epithelial lesions induced by acrolein. J Environ Pathol Toxicol Oncol 9:159\u2013169","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"20_CR86","doi-asserted-by":"publisher","first-page":"R111","DOI":"10.1152\/ajpregu.00728.2007","volume":"295","author":"SD Guerios","year":"2008","unstructured":"Guerios SD, Wang ZY, Boldon K, Bushman W, Bjorling DE (2008) Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats. Am J Physiol Regul Integr Comp Physiol 295:R111\u2013R122","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"20_CR87","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/nau.20670","volume":"28","author":"SD Guerios","year":"2009","unstructured":"Guerios SD, Wang ZY, Boldon K, Bushman W, Bjorling DE (2009) Lidocaine prevents referred hyperalgesia associated with cystitis. Neurourol Urodyn 28:455\u2013460","journal-title":"Neurourol Urodyn"},{"key":"20_CR88","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neulet.2008.08.076","volume":"445","author":"FV Merriam","year":"2008","unstructured":"Merriam FV, Wang ZY, Guerios SD, Bjorling DE (2008) Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats. Neurosci Lett 445:130\u2013134","journal-title":"Neurosci Lett"},{"issue":"7","key":"20_CR89","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/j.1464-410X.2010.09583.x","volume":"108","author":"FV Merriam","year":"2011","unstructured":"Merriam FV, Wang ZY, Hillard CJ, Stuhr KL, Bjorling DE (2011) Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation. BJU Int 108(7):1145\u20131149","journal-title":"BJU Int"},{"key":"20_CR90","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1111\/j.1464-410X.2007.06773.x","volume":"99","author":"DE Bjorling","year":"2007","unstructured":"Bjorling DE, Elkahwaji JE, Bushman W et al (2007) Acute acrolein-induced cystitis in mice. BJU Int 99:1523\u20131529","journal-title":"BJU Int"},{"key":"20_CR91","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.pain.2008.03.020","volume":"139","author":"ZY Wang","year":"2008","unstructured":"Wang ZY, Wang P, Merriam FV, Bjorling DE (2008) Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain 139:158\u2013167","journal-title":"Pain"},{"key":"20_CR92","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1111\/j.1464-410X.2008.07891.x","volume":"102","author":"YH Lin","year":"2008","unstructured":"Lin YH, Liu G, Kavran M et al (2008) Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis. BJU Int 102:1724\u20131730","journal-title":"BJU Int"},{"key":"20_CR93","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.ymthe.2006.04.009","volume":"14","author":"R Jaini","year":"2006","unstructured":"Jaini R, Hannaman D, Johnson JM et al (2006) Gene-based intramuscular interferon-beta therapy for experimental autoimmune encephalomyelitis. Mol Ther 14:416\u2013422","journal-title":"Mol Ther"},{"key":"20_CR94","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.4049\/jimmunol.169.11.6507","volume":"169","author":"D Jane-wit","year":"2002","unstructured":"Jane-wit D, Yu M, Edling AE et al (2002) A novel class II-binding motif selects peptides that mediate organ-specific autoimmune disease in SWXJ, SJL\/J, and SWR\/J mice. J Immunol 169:6507\u20136514","journal-title":"J Immunol"},{"issue":"1","key":"20_CR95","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.eururo.2011.06.028","volume":"61","author":"CZ Altuntas","year":"2012","unstructured":"Altuntas CZ, Daneshgari F, Sakalar C et al (2012) Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis. Eur Urol 61(1):193\u2013200","journal-title":"Eur Urol"},{"key":"20_CR96","first-page":"937061","volume":"2011","author":"R Kim","year":"2011","unstructured":"Kim R, Liu W, Chen X, Kreder KJ, Luo Y (2011) Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models. J Biomed Biotechnol 2011:937061","journal-title":"J Biomed Biotechnol"},{"key":"20_CR97","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4049\/jimmunol.178.1.539","volume":"178","author":"W Liu","year":"2007","unstructured":"Liu W, Evanoff DP, Chen X, Luo Y (2007) Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response. J Immunol 178:539\u2013546","journal-title":"J Immunol"},{"key":"20_CR98","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1464-410X.2006.06274.x","volume":"98","author":"M Rajasekaran","year":"2006","unstructured":"Rajasekaran M, Locke KW, Parsons CL (2006) MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model. BJU Int 98:430\u2013434","journal-title":"BJU Int"},{"key":"20_CR99","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/sj.bjp.0701793","volume":"124","author":"A Ahluwalia","year":"1998","unstructured":"Ahluwalia A, Giuliani S, Scotland R, Maggi CA (1998) Ovalbumin-induced neurogenic inflammation in the bladder of sensitized rats. Br J Pharmacol 124:190\u2013196","journal-title":"Br J Pharmacol"}],"container-title":["Methods in Pharmacology and Toxicology","TRP Channels in Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-077-9_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T15:30:06Z","timestamp":1714404606000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-62703-077-9_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9781627030762","9781627030779"],"references-count":99,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-077-9_20","relation":{},"ISSN":["1557-2153","1940-6053"],"issn-type":[{"type":"print","value":"1557-2153"},{"type":"electronic","value":"1940-6053"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"2 August 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}