{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:50:49Z","timestamp":1726033849737},"publisher-location":"Cham","reference-count":60,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030118112"},{"type":"electronic","value":"9783030118129"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-11812-9_5","type":"book-chapter","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T03:45:15Z","timestamp":1561607115000},"page":"75-96","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Instability: DNA Repair and Cancer"],"prefix":"10.1007","author":[{"given":"Ana Rita","family":"Carlos","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"5_CR1","volume-title":"Genomes","author":"TA Brown","year":"2002","unstructured":"Brown TA (2002) Genomes. Wiley-Liss, Oxford. \n                  http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20821850\n                  \n                . Accessed 7 June 2018"},{"issue":"22","key":"5_CR2","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1093\/hmg\/ddu309","volume":"23","author":"I Ezkurdia","year":"2014","unstructured":"Ezkurdia I, Juan D, Rodriguez JM et al (2014) Multiple evidence strands suggest that there may be as few as 19 000 human protein-coding genes. Hum Mol Genet 23(22):5866\u20135878. \n                  https:\/\/doi.org\/10.1093\/hmg\/ddu309","journal-title":"Hum Mol Genet"},{"issue":"12","key":"5_CR3","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/nrg3275","volume":"13","author":"EA Schon","year":"2012","unstructured":"Schon EA, DiMauro S, Hirano M (2012) Human mitochondrial DNA: roles of inherited and somatic mutations. Nat Rev Genet 13(12):878\u2013890. \n                  https:\/\/doi.org\/10.1038\/nrg3275","journal-title":"Nat Rev Genet"},{"key":"5_CR4","volume-title":"Molecular cell biology","author":"HF Lodish","year":"2008","unstructured":"Lodish HF (2008) Molecular cell biology, 6th edn. W.H. Freeman, New York","edition":"6"},{"key":"5_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","volume":"73","author":"A Sancar","year":"2004","unstructured":"Sancar A, Lindsey-Boltz LA, Unsal-Ka\u00e7maz K, Linn S (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39\u201385. \n                  https:\/\/doi.org\/10.1146\/annurev.biochem.73.011303.073723","journal-title":"Annu Rev Biochem"},{"issue":"6627","key":"5_CR6","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/386761a0","volume":"386","author":"KW Kinzler","year":"1997","unstructured":"Kinzler KW, Vogelstein B (1997) Gatekeepers and caretakers. Nature 386(6627):761\u2013763. \n                  https:\/\/doi.org\/10.1038\/386761a0","journal-title":"Nature"},{"issue":"1","key":"5_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrc.2015.2","volume":"16","author":"WP Roos","year":"2016","unstructured":"Roos WP, Thomas AD, Kaina B (2016) DNA damage and the balance between survival and death in cancer biology. Nat Rev Cancer 16(1):20\u201333. \n                  https:\/\/doi.org\/10.1038\/nrc.2015.2","journal-title":"Nat Rev Cancer"},{"issue":"7381","key":"5_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nature10760","volume":"481","author":"CJ Lord","year":"2012","unstructured":"Lord CJ, Ashworth A (2012) The DNA damage response and cancer therapy. Nature 481(7381):287\u2013294. \n                  https:\/\/doi.org\/10.1038\/nature10760","journal-title":"Nature"},{"issue":"1","key":"5_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.tcb.2015.07.009","volume":"26","author":"R Ceccaldi","year":"2016","unstructured":"Ceccaldi R, Rondinelli B, D\u2019Andrea AD (2016) Repair pathway choices and consequences at the double-Strand break. Trends Cell Biol 26(1):52\u201364. \n                  https:\/\/doi.org\/10.1016\/j.tcb.2015.07.009","journal-title":"Trends Cell Biol"},{"issue":"2","key":"5_CR10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tcb.2013.09.003","volume":"24","author":"M Zimmermann","year":"2014","unstructured":"Zimmermann M, de Lange T (2014) 53BP1: pro choice in DNA repair. Trends Cell Biol 24(2):108\u2013117. \n                  https:\/\/doi.org\/10.1016\/j.tcb.2013.09.003","journal-title":"Trends Cell Biol"},{"issue":"8","key":"5_CR11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nrm.2017.48","volume":"18","author":"HHY Chang","year":"2017","unstructured":"Chang HHY, Pannunzio NR, Adachi N, Lieber MR (2017) Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol 18(8):495\u2013506. \n                  https:\/\/doi.org\/10.1038\/nrm.2017.48","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.dnarep.2016.05.003","volume":"44","author":"RD Wood","year":"2016","unstructured":"Wood RD, Doubli\u00e9 S (2016) DNA polymerase \u03b8 (POLQ), double-strand break repair, and cancer. DNA Repair (Amst) 44:22\u201332. \n                  https:\/\/doi.org\/10.1016\/j.dnarep.2016.05.003","journal-title":"DNA Repair (Amst)"},{"issue":"9","key":"5_CR13","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.tig.2016.06.007","volume":"32","author":"R Bhargava","year":"2016","unstructured":"Bhargava R, Onyango DO, Stark JM (2016) Regulation of single-strand annealing and its role in genome maintenance. Trends Genet 32(9):566\u2013575. \n                  https:\/\/doi.org\/10.1016\/j.tig.2016.06.007","journal-title":"Trends Genet"},{"issue":"17","key":"5_CR14","doi-asserted-by":"publisher","first-page":"3682","DOI":"10.1016\/j.febslet.2010.07.029","volume":"584","author":"BJ Lamarche","year":"2010","unstructured":"Lamarche BJ, Orazio NI, Weitzman MD (2010) The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett 584(17):3682\u20133695. \n                  https:\/\/doi.org\/10.1016\/j.febslet.2010.07.029","journal-title":"FEBS Lett"},{"issue":"1","key":"5_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nsmb.1710","volume":"17","author":"P Huertas","year":"2010","unstructured":"Huertas P (2010) DNA resection in eukaryotes: deciding how to fix the break. Nat Struct Mol Biol 17(1):11\u201316. \n                  https:\/\/doi.org\/10.1038\/nsmb.1710","journal-title":"Nat Struct Mol Biol"},{"issue":"9","key":"5_CR16","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.dnarep.2009.04.017","volume":"8","author":"EP Mimitou","year":"2009","unstructured":"Mimitou EP, Symington LS (2009) DNA end resection: many nucleases make light work. DNA Repair (Amst) 8(9):983\u2013995. \n                  https:\/\/doi.org\/10.1016\/j.dnarep.2009.04.017","journal-title":"DNA Repair (Amst)"},{"issue":"4","key":"5_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.molcel.2013.04.032","volume":"50","author":"H Chen","year":"2013","unstructured":"Chen H, Lisby M, Symington LS (2013) RPA coordinates DNA end resection and prevents formation of DNA hairpins. Mol Cell 50(4):589\u2013600. \n                  https:\/\/doi.org\/10.1016\/j.molcel.2013.04.032","journal-title":"Mol Cell"},{"issue":"5","key":"5_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1139\/bcb-2016-0012","volume":"94","author":"SK Godin","year":"2016","unstructured":"Godin SK, Sullivan MR, Bernstein KA (2016) Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication. Biochem Cell Biol 94(5):407\u2013418. \n                  https:\/\/doi.org\/10.1139\/bcb-2016-0012","journal-title":"Biochem Cell Biol"},{"issue":"8","key":"5_CR19","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.semcdb.2011.07.019","volume":"22","author":"N Suwaki","year":"2011","unstructured":"Suwaki N, Klare K, Tarsounas M (2011) RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis. Semin Cell Dev Biol 22(8):898\u2013905. \n                  https:\/\/doi.org\/10.1016\/j.semcdb.2011.07.019","journal-title":"Semin Cell Dev Biol"},{"issue":"9","key":"5_CR20","doi-asserted-by":"publisher","first-page":"a023192","DOI":"10.1101\/cshperspect.a023192","volume":"6","author":"HDM Wyatt","year":"2014","unstructured":"Wyatt HDM, West SC (2014) Holliday junction resolvases. Cold Spring Harb Perspect Biol 6(9):a023192\u2013a023192. \n                  https:\/\/doi.org\/10.1101\/cshperspect.a023192","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"21","key":"5_CR21","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1038\/emboj.2009.276","volume":"28","author":"A Beucher","year":"2009","unstructured":"Beucher A, Birraux J, Tchouandong L et al (2009) ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J 28(21):3413\u20133427. \n                  https:\/\/doi.org\/10.1038\/emboj.2009.276","journal-title":"EMBO J"},{"issue":"4","key":"5_CR22","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.cell.2015.09.057","volume":"163","author":"F Lottersberger","year":"2015","unstructured":"Lottersberger F, Karssemeijer RA, Dimitrova N, de Lange T (2015) 53BP1 and the LINC complex promote microtubule-dependent DSB mobility and DNA repair. Cell 163(4):880\u2013893. \n                  https:\/\/doi.org\/10.1016\/j.cell.2015.09.057","journal-title":"Cell"},{"issue":"4","key":"5_CR23","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.molcel.2016.12.016","volume":"65","author":"R Biehs","year":"2017","unstructured":"Biehs R, Steinlage M, Barton O et al (2017) DNA double-strand break resection occurs during non-homologous end joining in G1 but is distinct from resection during homologous recombination. Mol Cell 65(4):671\u2013684.e5. \n                  https:\/\/doi.org\/10.1016\/j.molcel.2016.12.016","journal-title":"Mol Cell"},{"issue":"56","key":"5_CR24","doi-asserted-by":"publisher","first-page":"7780","DOI":"10.1038\/sj.onc.1210875","volume":"26","author":"P Soulas-Sprauel","year":"2007","unstructured":"Soulas-Sprauel P, Rivera-Munoz P, Malivert L et al (2007) V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining. Oncogene 26(56):7780\u20137791. \n                  https:\/\/doi.org\/10.1038\/sj.onc.1210875","journal-title":"Oncogene"},{"issue":"12","key":"5_CR25","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1084\/jem.20081623","volume":"205","author":"L Han","year":"2008","unstructured":"Han L, Yu K (2008) Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV\u2013deficient B cells. J Exp Med 205(12):2745\u20132753. \n                  https:\/\/doi.org\/10.1084\/jem.20081623","journal-title":"J Exp Med"},{"issue":"12","key":"5_CR26","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1101\/GAD.10.12.1433","volume":"10","author":"R Kolodner","year":"1996","unstructured":"Kolodner R (1996) Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 10(12):1433\u20131442. \n                  https:\/\/doi.org\/10.1101\/GAD.10.12.1433","journal-title":"Genes Dev"},{"issue":"8","key":"5_CR27","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nrg2380","volume":"9","author":"KW Caldecott","year":"2008","unstructured":"Caldecott KW (2008) Single-strand break repair and genetic disease. Nat Rev Genet 9(8):619\u2013631. \n                  https:\/\/doi.org\/10.1038\/nrg2380","journal-title":"Nat Rev Genet"},{"key":"5_CR28","doi-asserted-by":"publisher","unstructured":"Blackford AN, Jackson SP (2017) ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response. Mol Cell 66(6):801\u2013817. doi:S1097-2765(17)30354-4 [pii]. \n                  https:\/\/doi.org\/10.1016\/j.molcel.2017.05.015","DOI":"10.1016\/j.molcel.2017.05.015"},{"issue":"4","key":"5_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nrm2351","volume":"9","author":"D Branzei","year":"2008","unstructured":"Branzei D, Foiani M (2008) Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 9(4):297\u2013308. \n                  https:\/\/doi.org\/10.1038\/nrm2351","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"5_CR30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrm3546","volume":"14","author":"Y Shiloh","year":"2013","unstructured":"Shiloh Y, Ziv Y (2013) The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 14(4):197\u2013210. \n                  https:\/\/doi.org\/10.1038\/nrm3546","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"45","key":"5_CR31","doi-asserted-by":"publisher","first-page":"42462","DOI":"10.1074\/jbc.C100466200","volume":"276","author":"S Burma","year":"2001","unstructured":"Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276(45):42462\u201342467. \n                  https:\/\/doi.org\/10.1074\/jbc.C100466200","journal-title":"J Biol Chem"},{"issue":"2","key":"5_CR32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ceb.2009.01.018","volume":"21","author":"HC Reinhardt","year":"2009","unstructured":"Reinhardt HC, Yaffe MB (2009) Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 21(2):245\u2013255. \n                  https:\/\/doi.org\/10.1016\/j.ceb.2009.01.018","journal-title":"Curr Opin Cell Biol"},{"issue":"5","key":"5_CR33","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/embor.2013.25","volume":"14","author":"LA Carvajal","year":"2013","unstructured":"Carvajal LA, Manfredi JJ (2013) Another fork in the road\u2014life or death decisions by the tumour suppressor p53. EMBO Rep 14(5):414\u2013421. \n                  https:\/\/doi.org\/10.1038\/embor.2013.25","journal-title":"EMBO Rep"},{"issue":"5","key":"5_CR34","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrc3711","volume":"14","author":"KT Bieging","year":"2014","unstructured":"Bieging KT, Mello SS, Attardi LD (2014) Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer 14(5):359\u2013370. \n                  https:\/\/doi.org\/10.1038\/nrc3711","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"5_CR35","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nrc3344","volume":"12","author":"G Sulli","year":"2012","unstructured":"Sulli G, Di Micco R, di Fagagna F d\u2019A (2012) Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer 12(10):709\u2013720. \n                  https:\/\/doi.org\/10.1038\/nrc3344","journal-title":"Nat Rev Cancer"},{"key":"5_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.dnarep.2016.05.020","volume":"44","author":"GR Kidiyoor","year":"2016","unstructured":"Kidiyoor GR, Kumar A, Foiani M (2016) ATR-mediated regulation of nuclear and cellular plasticity. DNA Repair (Amst) 44:143\u2013150. \n                  https:\/\/doi.org\/10.1016\/j.dnarep.2016.05.020","journal-title":"DNA Repair (Amst)"},{"issue":"3","key":"5_CR37","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nrm2852","volume":"11","author":"D Branzei","year":"2010","unstructured":"Branzei D, Foiani M (2010) Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol 11(3):208\u2013219. \n                  https:\/\/doi.org\/10.1038\/nrm2852","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"5_CR38","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrc2723","volume":"9","author":"AJ Levine","year":"2009","unstructured":"Levine AJ, Oren M (2009) The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9(10):749\u2013758. \n                  https:\/\/doi.org\/10.1038\/nrc2723","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"5_CR39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S1044-579X(02)00099-8","volume":"13","author":"D Michael","year":"2003","unstructured":"Michael D, Oren M (2003) The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13(1):49\u201358. \n                  http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12507556\n                  \n                . Accessed 8 June 2018","journal-title":"Semin Cancer Biol"},{"issue":"6381","key":"5_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/358015a0","volume":"358","author":"DP Lane","year":"1992","unstructured":"Lane DP (1992) p53, guardian of the genome. Nature 358(6381):15\u201316. \n                  https:\/\/doi.org\/10.1038\/358015a0","journal-title":"Nature"},{"issue":"4","key":"5_CR41","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrm2147","volume":"8","author":"KH Vousden","year":"2007","unstructured":"Vousden KH, Lane DP (2007) p53 in health and disease. Nat Rev Mol Cell Biol 8(4):275\u2013283. \n                  https:\/\/doi.org\/10.1038\/nrm2147","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"5_CR42","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/nrc2730","volume":"9","author":"D Menendez","year":"2009","unstructured":"Menendez D, Inga A, Resnick MA (2009) The expanding universe of p53 targets. Nat Rev Cancer 9(10):724\u2013737. \n                  https:\/\/doi.org\/10.1038\/nrc2730","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"5_CR43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrm3735","volume":"15","author":"G Mari\u00f1o","year":"2014","unstructured":"Mari\u00f1o G, Niso-Santano M, Baehrecke EH, Kroemer G (2014) Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol 15(2):81\u201394. \n                  https:\/\/doi.org\/10.1038\/nrm3735","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"5_CR44","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrc3960","volume":"15","author":"NE Sharpless","year":"2015","unstructured":"Sharpless NE, Sherr CJ (2015) Forging a signature of in vivo senescence. Nat Rev Cancer 15(7):397\u2013408. \n                  https:\/\/doi.org\/10.1038\/nrc3960","journal-title":"Nat Rev Cancer"},{"key":"5_CR45","doi-asserted-by":"publisher","unstructured":"He S, Sharpless NE (2017) Senescence in health and disease. Cell 169(6):1000\u20131011. doi:S0092-8674(17)30546-9 [pii]. \n                  https:\/\/doi.org\/10.1016\/j.cell.2017.05.015","DOI":"10.1016\/j.cell.2017.05.015"},{"key":"5_CR46","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","volume":"42","author":"W Palm","year":"2008","unstructured":"Palm W, de Lange T (2008) How shelterin protects mammalian telomeres. Annu Rev Genet 42:301\u2013334. \n                  https:\/\/doi.org\/10.1146\/annurev.genet.41.110306.130350","journal-title":"Annu Rev Genet"},{"issue":"3","key":"5_CR47","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc3025","volume":"11","author":"P Mart\u00ednez","year":"2011","unstructured":"Mart\u00ednez P, Blasco MA (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 11(3):161\u2013176. \n                  https:\/\/doi.org\/10.1038\/nrc3025","journal-title":"Nat Rev Cancer"},{"issue":"5955","key":"5_CR48","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1126\/science.1170633","volume":"326","author":"T Lange de","year":"2009","unstructured":"de Lange T (2009) How telomeres solve the end-protection problem. Science 326(5955):948\u2013952. \n                  https:\/\/doi.org\/10.1126\/science.1170633","journal-title":"Science"},{"issue":"3","key":"5_CR49","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nrm2848","volume":"11","author":"RJ O\u2019Sullivan","year":"2010","unstructured":"O\u2019Sullivan RJ, Karlseder J (2010) Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 11(3):171\u2013181. \n                  https:\/\/doi.org\/10.1038\/nrm2848","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"5_CR50","doi-asserted-by":"publisher","first-page":"a016576","DOI":"10.1101\/cshperspect.a016576","volume":"6","author":"Y Doksani","year":"2014","unstructured":"Doksani Y, de Lange T (2014) The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harb Perspect Biol 6(12):a016576\u2013a016576. \n                  https:\/\/doi.org\/10.1101\/cshperspect.a016576","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"5_CR51","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nrm.2016.171","volume":"18","author":"J Maciejowski","year":"2017","unstructured":"Maciejowski J, de Lange T (2017) Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol 18(3):175\u2013186. \n                  https:\/\/doi.org\/10.1038\/nrm.2016.171","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"17","key":"5_CR52","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/S0960-9822(03)00542-6","volume":"13","author":"H Takai","year":"2003","unstructured":"Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13(17):1549\u20131556. \n                  http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12956959\n                  \n                . Accessed 8 June 2018","journal-title":"Curr Biol"},{"issue":"6963","key":"5_CR53","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nature02118","volume":"426","author":"F d\u2019A di Fagagna","year":"2003","unstructured":"di Fagagna F d\u2019A, Reaper PM, Clay-Farrace L et al (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426(6963):194\u2013198. \n                  https:\/\/doi.org\/10.1038\/nature02118","journal-title":"Nature"},{"issue":"3","key":"5_CR54","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1073\/pnas.0334858100","volume":"100","author":"LA Loeb","year":"2003","unstructured":"Loeb LA, Loeb KR, Anderson JP (2003) Multiple mutations and cancer. Proc Natl Acad Sci U S A 100(3):776\u2013781. \n                  https:\/\/doi.org\/10.1073\/pnas.0334858100","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"5_CR55","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674. \n                  https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"issue":"3","key":"5_CR56","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nrm2858","volume":"11","author":"S Negrini","year":"2010","unstructured":"Negrini S, Gorgoulis VG, Halazonetis TD (2010) Genomic instability\u2013an evolving hallmark of cancer. Nat Rev Mol Cell Biol 11(3):220\u2013228. \n                  https:\/\/doi.org\/10.1038\/nrm2858","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"5_CR57","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ncb2641","volume":"15","author":"PAJ Muller","year":"2013","unstructured":"Muller PAJ, Vousden KH (2013) p53 mutations in cancer. Nat Cell Biol 15(1):2\u20138. \n                  https:\/\/doi.org\/10.1038\/ncb2641","journal-title":"Nat Cell Biol"},{"key":"5_CR58","doi-asserted-by":"publisher","unstructured":"Callaway E (2015) How elephants avoid cancer. Nature. \n                  https:\/\/doi.org\/10.1038\/nature.2015.18534","DOI":"10.1038\/nature.2015.18534"},{"issue":"1","key":"5_CR59","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1146\/annurev-med-050913-022545","volume":"66","author":"CJ Lord","year":"2015","unstructured":"Lord CJ, Tutt ANJ, Ashworth A (2015) Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors. Annu Rev Med 66(1):455\u2013470. \n                  https:\/\/doi.org\/10.1146\/annurev-med-050913-022545","journal-title":"Annu Rev Med"},{"issue":"1","key":"5_CR60","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nrclinonc.2014.163","volume":"12","author":"A Sonnenblick","year":"2015","unstructured":"Sonnenblick A, de Azambuja E, Azim HA, Piccart M (2015) An update on PARP inhibitors\u2014moving to the adjuvant setting. Nat Rev Clin Oncol 12(1):27\u201341. \n                  https:\/\/doi.org\/10.1038\/nrclinonc.2014.163","journal-title":"Nat Rev Clin Oncol"}],"container-title":["Learning Materials in Biosciences","Molecular and Cell Biology of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-11812-9_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T04:59:28Z","timestamp":1561611568000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-11812-9_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030118112","9783030118129"],"references-count":60,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-11812-9_5","relation":{},"ISSN":["2509-6125","2509-6133"],"issn-type":[{"type":"print","value":"2509-6125"},{"type":"electronic","value":"2509-6133"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"27 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}