{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T07:44:28Z","timestamp":1742975068961,"version":"3.40.3"},"publisher-location":"Cham","reference-count":28,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030153700"},{"type":"electronic","value":"9783030153724"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-15372-4_5","type":"book-chapter","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T13:10:29Z","timestamp":1553692229000},"page":"67-86","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Biomechanical Approach for Bone Regeneration Inside Scaffolds Embedded with BMP-2"],"prefix":"10.1007","author":[{"given":"C.","family":"Gorriz","sequence":"first","affiliation":[]},{"given":"F.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"J. M.","family":"Guedes","sequence":"additional","affiliation":[]},{"given":"J.","family":"Folgado","sequence":"additional","affiliation":[]},{"given":"P. R.","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"issue":"7","key":"5_CR1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.msec.2011.04.022","volume":"31","author":"Q Fu","year":"2011","unstructured":"Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C 31(7):1245\u20131256","journal-title":"Mater Sci Eng C"},{"key":"5_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cma.2006.09.023","volume":"196","author":"SJ Hollister","year":"2007","unstructured":"Hollister SJ, Lin CY (2007) Computational design of tissue engineering scaffold. Comput Methods Appl Mech Eng 196:31\u201332","journal-title":"Comput Methods Appl Mech Eng"},{"issue":"4","key":"5_CR3","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.medengphy.2014.02.010","volume":"36","author":"MR Dias","year":"2014","unstructured":"Dias MR, Guedes JM, Flanagan CL, Hollister SJ, Fernandes PR (2014) Optimization of scaffold design for bone tissue engineering: a computational and experimental study. Med Eng Phys 36(4):448\u2013457","journal-title":"Med Eng Phys"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"035012","DOI":"10.1088\/1758-5082\/5\/3\/035012","volume":"5","author":"M Castilho","year":"2013","unstructured":"Castilho M, Dias M, Gbureck U, Groll J, Fernandes P, Pires I, Gouveia B, Rodrigues J, Vorndran E (2013) Fabrication of computationally designed scaffolds by low temperature 3D printing. Biofabrication 5:035012","journal-title":"Biofabrication"},{"issue":"6","key":"5_CR5","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.msec.2009.03.003","volume":"29","author":"G Chao","year":"2009","unstructured":"Chao G, Xiaobo S, Chenglin C, Yinsheng D, Yuepu P, Pinghua L (2009) A cellular automaton simulation of the degradation of porous polylactide scaffold: I. Effect of porosity. Mater Sci Eng C 29(6):1950\u20131958","journal-title":"Mater Sci Eng C"},{"issue":"16","key":"5_CR6","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1021\/ma00068a006","volume":"26","author":"A G\u00f6pferich","year":"1993","unstructured":"G\u00f6pferich A, Langer R (1993) Modeling of polymer erosion. Macromolecules 26(16):4105\u20134112","journal-title":"Macromolecules"},{"issue":"9","key":"5_CR7","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1021\/ma961627y","volume":"30","author":"A G\u00f6pferich","year":"1997","unstructured":"G\u00f6pferich A (1997) Polymer bulk erosion. Macromolecules 30(9):2598\u20132604","journal-title":"Macromolecules"},{"issue":"9","key":"5_CR8","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/mats.200600036","volume":"15","author":"Y Mohammadi","year":"2006","unstructured":"Mohammadi Y, Jabbari E (2006) Monte Carlo simulation of degradation of porous poly (lactide) scaffolds, 1. Macromol Theory Simul 15(9):643\u2013653","journal-title":"Macromol Theory Simul"},{"issue":"3","key":"5_CR9","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.actbio.2010.09.038","volume":"7","author":"Y Chen","year":"2011","unstructured":"Chen Y, Zhou S, Li Q (2011) Mathematical modeling of degradation for bulkerosive polymers: applications in tissue engineering scaffolds and drug delivery systems. Acta Biomater 7(3):1140\u20131149","journal-title":"Acta Biomater"},{"key":"5_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10237-007-0089-7","volume":"7","author":"J Sanz-Herrera","year":"2007","unstructured":"Sanz-Herrera J, Garcia-Aznar J, Doblare M (2007) A mathematical approach for tissue regeneration inside a specific type of scaffold. Biomech Model Mechanobiol 7:355\u2013366","journal-title":"Biomech Model Mechanobiol"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1016\/j.biomaterials.2006.02.039","volume":"27","author":"T Adachi","year":"2006","unstructured":"Adachi T, Osako Y, Tanaka M, Hojo M, Hollister SJ (2006) Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration. Biomaterials 27:3964\u20133972","journal-title":"Biomaterials"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.proeng.2015.07.013","volume":"110","author":"C Gorriz","year":"2015","unstructured":"Gorriz C, Ribeiro F, Guedes JM, Fernandes PR (2015) A biomechanical approach for bone regeneration inside scaffolds. Procedia Eng 110:82\u201389","journal-title":"Procedia Eng"},{"issue":"5","key":"5_CR13","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","volume":"19","author":"A Schindeler","year":"2008","unstructured":"Schindeler A, McDonald MM, Bokko P, Little DG (2008) Bone remodeling during fracture repair: the cellular picture. Semin Cell Dev Biol 19(5):459\u2013466","journal-title":"Semin Cell Dev Biol"},{"key":"5_CR14","first-page":"317","volume":"293","author":"TN Gerhart","year":"1993","unstructured":"Gerhart TN, Kirker-Head CA, Kriz MJ, Holtrop ME, Hennig GE, Hipp J, Schelling SH, Wang E (1993) Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop Relat Res 293:317\u2013326","journal-title":"Clin Orthop Relat Res"},{"key":"5_CR15","first-page":"11","volume":"17","author":"P Boyne","year":"1997","unstructured":"Boyne P, Marx RE, Nevins M, Lazaro E, Le Lilly AM, Nummikoski P (1997) A feasibility study evaluating rhbmp-2\/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Period Restor Dent 17:11\u201325","journal-title":"Int J Period Restor Dent"},{"issue":"1","key":"5_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2200\/S00246ED1V01Y200912TIS004","volume":"2","author":"X Wang","year":"2010","unstructured":"Wang X, Nyman JS, Dong X, Leng H, Reyes M (2010) Fundamental biomechanics in bone tissue engineering. Synth Lect Tissue Eng 2(1):1\u2013225","journal-title":"Synth Lect Tissue Eng"},{"issue":"6","key":"5_CR17","doi-asserted-by":"publisher","first-page":"e0127722","DOI":"10.1371\/journal.pone.0127722","volume":"10","author":"FO Ribeiro","year":"2015","unstructured":"Ribeiro FO, Gomez-Benito MJ, Folgado J, Fernandes PR, Garcia-Aznar JM (2015) In silico mechano-chemical model of bone healing for regeneration of critical defects: the effect of BMP-2. PLoS ONE 10(6):e0127722","journal-title":"PLoS ONE"},{"key":"5_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0045-7825(90)90148-F","volume":"83","author":"JM Guedes","year":"1990","unstructured":"Guedes JM, Kikuchi N (1990) Preprocessing and postprocessing for materials based on the homogenization method with adaptive finite element methods. Comput Methods Appl Mech Eng 83:143\u2013198","journal-title":"Comput Methods Appl Mech Eng"},{"issue":"3","key":"5_CR19","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.actbio.2010.09.038","volume":"7","author":"Y Chen","year":"2011","unstructured":"Chen Y, Zhou S, Li Q (2011) Mathematical modeling of degradation for bulk-erosive polymers: applications in tissue engineering scaffolds and drug delivery systems. Acta Biomater 7(3):1140\u20131149","journal-title":"Acta Biomater"},{"issue":"1","key":"5_CR20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jtbi.2004.12.023","volume":"235","author":"MJ G\u00f3mez-Benito","year":"2005","unstructured":"G\u00f3mez-Benito MJ, Garc\u00eda-Aznar JM, Kuiper JH, Doblar\u00e9 M (2005) Influence of fracture gap size on the pattern of long bone healing: a computational study. J Theor Biol 235(1):105\u2013119","journal-title":"J Theor Biol"},{"issue":"6","key":"5_CR21","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jbiomech.2012.01.019","volume":"45","author":"MR Dias","year":"2012","unstructured":"Dias MR, Fernandes PR, Guedes JM, Hollister SJ (2012) Permeability analysis of scaffolds for bone tissue engineering. J Biomech 45(6):938\u2013944","journal-title":"J Biomech"},{"key":"5_CR22","unstructured":"Wu XS, Wang N (2001) Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic\/glycolic acid polymers. Part II: Biodegradation. J Biomater Sci Polym Ed 12(1):21\u201334"},{"issue":"2","key":"5_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10856-006-6816-2","volume":"17","author":"SH Oh","year":"2006","unstructured":"Oh SH, Kang SG, Lee JH (2006) Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: comparison with control hydrophobic one. J Mater Sci Mater Med 17(2):131\u2013137","journal-title":"J Mater Sci Mater Med"},{"issue":"1","key":"5_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/term.1497","volume":"8","author":"CV Rahman","year":"2014","unstructured":"Rahman CV, Ben-David D, Dhillon A, Kuhn G, Gould TW, M\u00fcller R, Rose FR, Shakesheff KM, Livne E (2014) Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model. J Tissue Eng Regen Med 8(1):59\u201366","journal-title":"J Tissue Eng Regen Med"},{"issue":"3","key":"5_CR25","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1089\/ten.2006.0141","volume":"13","author":"CM Cowan","year":"2007","unstructured":"Cowan CM, Aghaloo T, Chou YF, Walder B, Zhang X, Soo C, Wu B (2007) MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects. Tissue Eng 13(3):501\u2013512","journal-title":"Tissue Eng"},{"issue":"36","key":"5_CR26","doi-asserted-by":"publisher","first-page":"5544","DOI":"10.1016\/j.biomaterials.2007.09.003","volume":"28","author":"DP Byrne","year":"2007","unstructured":"Byrne DP, Lacroix D, Planell JA, Kelly DJ, Prendergast PJ (2007) Simulation of tissue differentiation in a scaffold as a function of porosity, young\u2019s modulus and dissolution rate: application of mechanobiological models in tissue engineering. Biomaterials 28(36):5544\u20135554","journal-title":"Biomaterials"},{"issue":"13","key":"5_CR27","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1016\/j.jbiomech.2010.05.027","volume":"43","author":"J Sanz-Herrera","year":"2010","unstructured":"Sanz-Herrera J, Doblar\u00e9 M, Garc\u00edaAznar J (2010) Scaffold microarchitecture determines internal bone directional growth structure: a numerical study. J Biomech 43(13):2480\u20132486","journal-title":"J Biomech"},{"issue":"9","key":"5_CR28","doi-asserted-by":"publisher","first-page":"e25462","DOI":"10.1371\/journal.pone.0025462","volume":"6","author":"MD Schofer","year":"2011","unstructured":"Schofer MD, Roessler PP, Schaefer J, Theisen C, Schlimme S, Heverhagen JT, Paletta JR (2011) Electrospun PLLA nanofiber scaffolds and their use in combination with BMP-2 for reconstruction of bone defects. PLoS ONE 6(9):e25462","journal-title":"PLoS ONE"}],"container-title":["Computational Methods in Applied Sciences","New Developments in Tissue Engineering and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-15372-4_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T13:21:33Z","timestamp":1558185693000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-15372-4_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030153700","9783030153724"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-15372-4_5","relation":{},"ISSN":["1871-3033"],"issn-type":[{"type":"print","value":"1871-3033"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"28 March 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}