{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:48:56Z","timestamp":1759776536311,"version":"3.40.3"},"publisher-location":"Cham","reference-count":153,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030444358"},{"type":"electronic","value":"9783030444365"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-44436-5_4","type":"book-chapter","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T18:02:55Z","timestamp":1590775375000},"page":"93-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Signaling Pathways Governing Activation of Innate Immune Cells"],"prefix":"10.1007","author":[{"given":"Bruno M.","family":"Neves","sequence":"first","affiliation":[]},{"given":"Catarina R.","family":"Almeida","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","volume":"174","author":"E Vivier","year":"2018","unstructured":"Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H (2018) Innate lymphoid cells: 10 years on. Cell 174:1054\u20131066. https:\/\/doi.org\/10.1016\/j.cell.2018.07.017","journal-title":"Cell"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805\u2013820. https:\/\/doi.org\/10.1016\/j.cell.2010.01.022","journal-title":"Cell"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/J.CELL.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783\u2013801. https:\/\/doi.org\/10.1016\/J.CELL.2006.02.015","journal-title":"Cell"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3389\/fimmu.2015.00422","volume":"6","author":"E V\u00e9n\u00e9reau","year":"2015","unstructured":"V\u00e9n\u00e9reau E, Ceriotti C, Bianchi ME (2015) DAMPs from cell death to new life. Front Immunol 6:422. https:\/\/doi.org\/10.3389\/fimmu.2015.00422","journal-title":"Front Immunol"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nri2873","volume":"10","author":"GY Chen","year":"2010","unstructured":"Chen GY, Nu\u00f1ez G (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10:826\u2013837. https:\/\/doi.org\/10.1038\/nri2873","journal-title":"Nat Rev Immunol"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/ni.3558","volume":"17","author":"Q Chen","year":"2016","unstructured":"Chen Q, Sun L, Chen ZJ (2016) Regulation and function of the cGAS\u2013STING pathway of cytosolic DNA sensing. Nat Immunol 17:1142\u20131149. https:\/\/doi.org\/10.1038\/ni.3558","journal-title":"Nat Immunol"},{"key":"4_CR7","doi-asserted-by":"publisher","DOI":"10.5772\/37771","author":"B Miguel","year":"2012","unstructured":"Miguel B, Celeste M, Teresa M (2012) Pathogen strategies to evade innate immune response: a signaling point of view. Protein Kinases. https:\/\/doi.org\/10.5772\/37771","journal-title":"Protein Kinases"},{"key":"4_CR8","doi-asserted-by":"publisher","unstructured":"Sancho D, Reis e Sousa C (2012) Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Ann Rev Immunol 30:491\u2013529. https:\/\/doi.org\/10.1146\/annurev-immunol-031210-101352","DOI":"10.1146\/annurev-immunol-031210-101352"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.virol.2015.02.017","volume":"479\u2013480","author":"AM Kell","year":"2015","unstructured":"Kell AM, Gale M (2015) RIG-I in RNA virus recognition. Virology 479\u2013480:110\u2013121. https:\/\/doi.org\/10.1016\/j.virol.2015.02.017","journal-title":"Virology"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ni.1703","volume":"10","author":"L Franchi","year":"2009","unstructured":"Franchi L, Eigenbrod T, Mu\u00f1oz-Planillo R, Nu\u00f1ez G (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10:241\u2013247. https:\/\/doi.org\/10.1038\/ni.1703","journal-title":"Nat Immunol"},{"key":"4_CR11","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","volume":"27","author":"T-D Kanneganti","year":"2007","unstructured":"Kanneganti T-D, Lamkanfi M, N\u00fa\u00f1ez G (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27:549\u2013559. https:\/\/doi.org\/10.1016\/j.immuni.2007.10.002","journal-title":"Immunity"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nm.3813","volume":"21","author":"B Dey","year":"2015","unstructured":"Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee J-H, Bishai WR (2015) A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat Med 21:401\u2013406. https:\/\/doi.org\/10.1038\/nm.3813","journal-title":"Nat Med"},{"key":"4_CR13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.chom.2016.01.010","volume":"19","author":"Z Ma","year":"2016","unstructured":"Ma Z, Damania B (2016) The cGAS-STINg defense pathway and its counteraction by viruses. Cell Host Microbe 19:150\u2013158. https:\/\/doi.org\/10.1016\/j.chom.2016.01.010","journal-title":"Cell Host Microbe"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","volume":"41","author":"R Caruso","year":"2014","unstructured":"Caruso R, Warner N, Inohara N, N\u00fa\u00f1ez G (2014) NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 41:898\u2013908. https:\/\/doi.org\/10.1016\/j.immuni.2014.12.010","journal-title":"Immunity"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.str.2011.02.004","volume":"19","author":"I Botos","year":"2011","unstructured":"Botos I, Segal DM, Davies DR (2011) The structural biology of Toll-like receptors. Structure\u00a019:447\u2013459. https:\/\/doi.org\/10.1016\/j.str.2011.02.004","journal-title":"Structure"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373\u2013384. https:\/\/doi.org\/10.1038\/ni.1863","journal-title":"Nat Immunol"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","volume":"5","author":"T Kawasaki","year":"2014","unstructured":"Kawasaki T, Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5:461. https:\/\/doi.org\/10.3389\/fimmu.2014.00461","journal-title":"Front Immunol"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nature09121","volume":"465","author":"S-C Lin","year":"2010","unstructured":"Lin S-C, Lo Y-C, Wu H (2010) Helical assembly in the MyD88\u2013IRAK4\u2013IRAK2 complex in TLR\/IL-1R signalling. Nature 465:885\u2013890. https:\/\/doi.org\/10.1038\/nature09121","journal-title":"Nature"},{"key":"4_CR19","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/ni.1606","volume":"9","author":"T Kawagoe","year":"2008","unstructured":"Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S (2008) Sequential control of toll-like receptor\u2013dependent responses by IRAK1 and IRAK2. Nat Immunol 9:684\u2013691. https:\/\/doi.org\/10.1038\/ni.1606","journal-title":"Nat Immunol"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nature08247","volume":"461","author":"Z-P Xia","year":"2009","unstructured":"Xia Z-P, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461:114\u2013119. https:\/\/doi.org\/10.1038\/nature08247","journal-title":"Nature"},{"key":"4_CR21","doi-asserted-by":"publisher","unstructured":"Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S (2003) Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science (80\u2013) 301:640\u2013643. https:\/\/doi.org\/10.1126\/science.1087262","DOI":"10.1126\/science.1087262"},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/ni886","volume":"4","author":"H Oshiumi","year":"2003","unstructured":"Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3\u2013mediated interferon-\u03b2 induction. Nat Immunol 4:161\u2013167. https:\/\/doi.org\/10.1038\/ni886","journal-title":"Nat Immunol"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature04369","volume":"439","author":"H H\u00e4cker","year":"2006","unstructured":"H\u00e4cker H, Redecke V, Blagoev B, Kratchmarova I, Hsu L-C, Wang GG, Kamps MP, Raz E, Wagner H, H\u00e4cker G, Mann M, Karin M (2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439:204\u2013207. https:\/\/doi.org\/10.1038\/nature04369","journal-title":"Nature"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41577-018-0004-8","volume":"18","author":"GD Brown","year":"2018","unstructured":"Brown GD, Willment JA, Whitehead L (2018) C-type lectins in immunity and homeostasis. Nat Rev Immunol 18:374\u2013389. https:\/\/doi.org\/10.1038\/s41577-018-0004-8","journal-title":"Nat Rev Immunol"},{"key":"4_CR25","doi-asserted-by":"publisher","unstructured":"Osorio F, Reis e Sousa C (2011) Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34:651\u2013664. https:\/\/doi.org\/10.1016\/j.immuni.2011.05.001","DOI":"10.1016\/j.immuni.2011.05.001"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/J.IMMUNI.2011.05.006","volume":"34","author":"T Kawai","year":"2011","unstructured":"Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637\u2013650. https:\/\/doi.org\/10.1016\/J.IMMUNI.2011.05.006","journal-title":"Immunity"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nri2765","volume":"10","author":"A M\u00f3csai","year":"2010","unstructured":"M\u00f3csai A, Ruland J, Tybulewicz VLJ (2010) The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 10:387\u2013402. https:\/\/doi.org\/10.1038\/nri2765","journal-title":"Nat Rev Immunol"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nri1745","volume":"6","author":"GD Brown","year":"2006","unstructured":"Brown GD (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 6:33\u201343. https:\/\/doi.org\/10.1038\/nri1745","journal-title":"Nat Rev Immunol"},{"key":"4_CR29","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature04926","volume":"442","author":"O Gross","year":"2006","unstructured":"Gross O, Gewies A, Finger K, Sch\u00e4fer M, Sparwasser T, Peschel C, F\u00f6rster I, Ruland J (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442:651\u2013656. https:\/\/doi.org\/10.1038\/nature04926","journal-title":"Nature"},{"key":"4_CR30","doi-asserted-by":"publisher","unstructured":"LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C (2007) Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8:630\u2013638. https:\/\/doi.org\/10.1038\/ni1460","DOI":"10.1038\/ni1460"},{"key":"4_CR31","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri2569","volume":"9","author":"TBH Geijtenbeek","year":"2009","unstructured":"Geijtenbeek TBH, Gringhuis SI (2009) Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol 9:465\u2013479. https:\/\/doi.org\/10.1038\/nri2569","journal-title":"Nat Rev Immunol"},{"key":"4_CR32","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1074\/jbc.M806650200","volume":"284","author":"S Xu","year":"2009","unstructured":"Xu S, Huo J, Lee K-G, Kurosaki T, Lam K-P (2009) Phospholipase C\u03b32 is critical for Dectin-1-mediated Ca2+\u2009flux and cytokine production in dendritic cells. J Biol Chem 284:7038\u20137046. https:\/\/doi.org\/10.1074\/jbc.M806650200","journal-title":"J Biol Chem"},{"key":"4_CR33","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.4049\/jimmunol.178.5.3107","volume":"178","author":"HS Goodridge","year":"2007","unstructured":"Goodridge HS, Simmons RM, Underhill DM (2007) Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol 178:3107\u20133115","journal-title":"J Immunol"},{"key":"4_CR34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature07965","volume":"459","author":"O Gross","year":"2009","unstructured":"Gross O, Poeck H, Bscheider M, Dostert C, Hannesschl\u00e4ger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J (2009) Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459:433\u2013436. https:\/\/doi.org\/10.1038\/nature07965","journal-title":"Nature"},{"key":"4_CR35","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/ni.1692","volume":"10","author":"SI Gringhuis","year":"2009","unstructured":"Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH (2009) Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol 10:203\u2013213. https:\/\/doi.org\/10.1038\/ni.1692","journal-title":"Nat Immunol"},{"key":"4_CR36","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.immuni.2010.05.001","volume":"32","author":"S Saijo","year":"2010","unstructured":"Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung S, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32:681\u2013691. https:\/\/doi.org\/10.1016\/j.immuni.2010.05.001","journal-title":"Immunity"},{"key":"4_CR37","doi-asserted-by":"publisher","unstructured":"Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gro\u00df O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C (2009) Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med 206:2037\u20132051. https:\/\/doi.org\/10.1084\/jem.20082818","DOI":"10.1084\/jem.20082818"},{"key":"4_CR38","doi-asserted-by":"publisher","first-page":"20459","DOI":"10.1073\/pnas.1010337107","volume":"107","author":"M Ritter","year":"2010","unstructured":"Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C (2010) Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci USA 107:20459\u201320464. https:\/\/doi.org\/10.1073\/pnas.1010337107","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR39","doi-asserted-by":"publisher","first-page":"e1006485","DOI":"10.1371\/journal.ppat.1006485","volume":"13","author":"T-H Chang","year":"2017","unstructured":"Chang T-H, Huang J-H, Lin H-C, Chen W-Y, Lee Y-H, Hsu L-C, Netea MG, Ting JP-Y, Wu-Hsieh BA (2017) Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum. PLoS Pathog 13:e1006485. https:\/\/doi.org\/10.1371\/journal.ppat.1006485","journal-title":"PLoS Pathog"},{"key":"4_CR40","doi-asserted-by":"publisher","first-page":"38854","DOI":"10.1074\/jbc.M606542200","volume":"281","author":"K Sato","year":"2006","unstructured":"Sato K, Yang X, Yudate T, Chung J-S, Wu J, Luby-Phelps K, Kimberly RP, Underhill D, Cruz PD, Ariizumi K (2006) Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor \u03b3 chain to induce innate immune responses. J Biol Chem 281:38854\u201338866. https:\/\/doi.org\/10.1074\/jbc.M606542200","journal-title":"J Biol Chem"},{"key":"4_CR41","doi-asserted-by":"publisher","first-page":"25969","DOI":"10.1074\/jbc.M110.131300","volume":"285","author":"L Bi","year":"2010","unstructured":"Bi L, Gojestani S, Wu W, Hsu Y-MS, Zhu J, Ariizumi K, Lin X (2010) CARD9 mediates dectin-2-induced I\u03baB\u03b1 kinase ubiquitination leading to activation of NF-\u03baB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem 285:25969\u201325977. https:\/\/doi.org\/10.1074\/jbc.M110.131300","journal-title":"J Biol Chem"},{"key":"4_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1046\/j.0022-202x.2001.01633.x","volume":"118","author":"N Kanazawa","year":"2002","unstructured":"Kanazawa N, Okazaki T, Nishimura H, Tashiro K, Inaba K, Miyachi Y (2002) DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif. J Invest Dermatol 118:261\u2013266. https:\/\/doi.org\/10.1046\/j.0022-202x.2001.01633.x","journal-title":"J Invest Dermatol"},{"key":"4_CR43","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.molimm.2015.10.007","volume":"68","author":"X Zhao","year":"2015","unstructured":"Zhao X, Shen Y, Hu W, Chen J, Wu T, Sun X, Yu J, Wu T, Chen W (2015) DCIR negatively regulates CpG-ODN-induced IL-1\u03b2 and IL-6 production. Mol Immunol 68:641\u2013647. https:\/\/doi.org\/10.1016\/j.molimm.2015.10.007","journal-title":"Mol Immunol"},{"key":"4_CR44","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1189\/jlb.0608352","volume":"85","author":"F Meyer-Wentrup","year":"2009","unstructured":"Meyer-Wentrup F, Cambi A, Joosten B, Looman MW, de Vries IJM, Figdor CG, Adema GJ (2009) DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. J Leukoc Biol 85:518\u2013525. https:\/\/doi.org\/10.1189\/jlb.0608352","journal-title":"J Leukoc Biol"},{"key":"4_CR45","doi-asserted-by":"publisher","first-page":"6589","DOI":"10.1182\/blood-2011-01-331363","volume":"117","author":"AA Lambert","year":"2011","unstructured":"Lambert AA, Barabe F, Gilbert C, Tremblay MJ (2011) DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. Blood 117:6589\u20136599. https:\/\/doi.org\/10.1182\/blood-2011-01-331363","journal-title":"Blood"},{"key":"4_CR46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.imlet.2013.11.007","volume":"158","author":"K Bloem","year":"2014","unstructured":"Bloem K, Vuist IM, van den Berk M, Klaver EJ, van Die I, Knippels LMJ, Garssen J, Garc\u00eda-Vallejo JJ, van Vliet SJ, van Kooyk Y (2014) DCIR interacts with ligands from both endogenous and pathogenic origin. Immunol Lett 158:33\u201341. https:\/\/doi.org\/10.1016\/j.imlet.2013.11.007","journal-title":"Immunol Lett"},{"key":"4_CR47","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/1873-3468.12162","volume":"590","author":"M Nagae","year":"2016","unstructured":"Nagae M, Ikeda A, Hanashima S, Kojima T, Matsumoto N, Yamamoto K, Yamaguchi Y (2016) Crystal structure of human dendritic cell inhibitory receptor C-type lectin domain reveals the binding mode with N-glycan. FEBS Lett 590:1280\u20131288. https:\/\/doi.org\/10.1002\/1873-3468.12162","journal-title":"FEBS Lett"},{"key":"4_CR48","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.cellsig.2010.03.018","volume":"22","author":"U \u0160vajger","year":"2010","unstructured":"\u0160vajger U, Anderluh M, Jeras M, Obermajer N (2010) C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity. Cell Signal 22:1397\u20131405. https:\/\/doi.org\/10.1016\/j.cellsig.2010.03.018","journal-title":"Cell Signal"},{"key":"4_CR49","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.immuni.2007.03.012","volume":"26","author":"SI Gringhuis","year":"2007","unstructured":"Gringhuis SI, den Dunnen J, Litjens M, van het Hof B, van Kooyk Y, Geijtenbeek TBH (2007) C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-\u03baB. Immunity 26:605\u2013616. https:\/\/doi.org\/10.1016\/j.immuni.2007.03.012","journal-title":"Immunity"},{"key":"4_CR50","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/ni.1778","volume":"10","author":"SI Gringhuis","year":"2009","unstructured":"Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TBH (2009) Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. Nat Immunol 10:1081\u20131088. https:\/\/doi.org\/10.1038\/ni.1778","journal-title":"Nat Immunol"},{"key":"4_CR51","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1371\/journal.ppat.0040031","volume":"4","author":"JWR Hovius","year":"2008","unstructured":"Hovius JWR, de Jong MAWP, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TBH (2008) Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog 4:e31. https:\/\/doi.org\/10.1371\/journal.ppat.0040031","journal-title":"PLoS Pathog"},{"key":"4_CR52","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ni1087","volume":"5","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5:730\u2013737. https:\/\/doi.org\/10.1038\/ni1087","journal-title":"Nat Immunol"},{"key":"4_CR53","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/ni1243","volume":"6","author":"T Kawai","year":"2005","unstructured":"Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6:981\u2013988. https:\/\/doi.org\/10.1038\/ni1243","journal-title":"Nat Immunol"},{"key":"4_CR54","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2010.04.018","volume":"141","author":"E Dixit","year":"2010","unstructured":"Dixit E, Boulant S, Zhang Y, Lee ASY, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141:668\u2013681. https:\/\/doi.org\/10.1016\/j.cell.2010.04.018","journal-title":"Cell"},{"key":"4_CR55","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","volume":"122","author":"RB Seth","year":"2005","unstructured":"Seth RB, Sun L, Ea C-K, Chen ZJ (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122:669\u2013682. https:\/\/doi.org\/10.1016\/j.cell.2005.08.012","journal-title":"Cell"},{"key":"4_CR56","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.4049\/jimmunol.176.8.4520","volume":"176","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S (2006) Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol 176:4520\u20134524","journal-title":"J Immunol"},{"key":"4_CR57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/ni.1824","volume":"11","author":"H Poeck","year":"2010","unstructured":"Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschl\u00e4ger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J (2010) Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1\u03b2 production. Nat Immunol 11:63\u201369. https:\/\/doi.org\/10.1038\/ni.1824","journal-title":"Nat Immunol"},{"key":"4_CR58","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1073\/pnas.0912986107","volume":"107","author":"T Satoh","year":"2010","unstructured":"Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O (2010) LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci 107:1512\u20131517. https:\/\/doi.org\/10.1073\/pnas.0912986107","journal-title":"Proc Natl Acad Sci"},{"key":"4_CR59","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/ni945","volume":"4","author":"M Chamaillard","year":"2003","unstructured":"Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Nu\u00f1ez G, Inohara N (2003) An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4:702\u2013707. https:\/\/doi.org\/10.1038\/ni945","journal-title":"Nat Immunol"},{"key":"4_CR60","doi-asserted-by":"publisher","first-page":"29054","DOI":"10.1074\/jbc.M602638200","volume":"281","author":"M Hasegawa","year":"2006","unstructured":"Hasegawa M, Yang K, Hashimoto M, Park J-H, Kim Y-G, Fujimoto Y, Nu\u00f1ez G, Fukase K, Inohara N (2006) Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. J Biol Chem 281:29054\u201329063. https:\/\/doi.org\/10.1074\/jbc.M602638200","journal-title":"J Biol Chem"},{"key":"4_CR61","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1074\/jbc.C200651200","volume":"278","author":"SE Girardin","year":"2003","unstructured":"Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ (2003) Nod2 is a general sensor of peptidoglycan through Muramyl Dipeptide (MDP) detection. J Biol Chem 278:8869\u20138872. https:\/\/doi.org\/10.1074\/jbc.C200651200","journal-title":"J Biol Chem"},{"key":"4_CR62","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1074\/jbc.M008072200","volume":"276","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G (2001) Nod2, a Nod1\/Apaf-1 family member that is restricted to monocytes and activates NF-\u03baB. J Biol Chem 276:4812\u20134818. https:\/\/doi.org\/10.1074\/jbc.M008072200","journal-title":"J Biol Chem"},{"key":"4_CR63","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20061704","volume":"404","author":"M Windheim","year":"2007","unstructured":"Windheim M, Lang C, Peggie M, Plater LA, Cohen P (2007) Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J 404:179\u2013190. https:\/\/doi.org\/10.1042\/BJ20061704","journal-title":"Biochem J"},{"key":"4_CR64","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/embo-reports\/kve155","volume":"2","author":"SE Girardin","year":"2001","unstructured":"Girardin SE, Tournebize R, Mavris M, Page AL, Li X, Stark GR, Bertin J, DiStefano PS, Yaniv M, Sansonetti PJ, Philpott DJ (2001) CARD4\/Nod1 mediates NF-\u03baB and JNK activation by invasive Shigella flexneri. EMBO Rep 2:736\u2013742. https:\/\/doi.org\/10.1093\/embo-reports\/kve155","journal-title":"EMBO Rep"},{"key":"4_CR65","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.4049\/jimmunol.178.4.2380","volume":"178","author":"J-H Park","year":"2007","unstructured":"Park J-H, Kim Y-G, McDonald C, Kanneganti T-D, Hasegawa M, Body-Malapel M, Inohara N, N\u00fa\u00f1ez G (2007) RICK\/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol 178:2380\u20132386","journal-title":"J Immunol"},{"key":"4_CR66","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nature04515","volume":"440","author":"S Mariathasan","year":"2006","unstructured":"Mariathasan S, Weiss DS, Newton K, McBride J, O\u2019Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228\u2013232. https:\/\/doi.org\/10.1038\/nature04515","journal-title":"Nature"},{"key":"4_CR67","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature02664","volume":"430","author":"S Mariathasan","year":"2004","unstructured":"Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213\u2013218. https:\/\/doi.org\/10.1038\/nature02664","journal-title":"Nature"},{"key":"4_CR68","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/imr.12618","volume":"281","author":"J Lugrin","year":"2018","unstructured":"Lugrin J, Martinon F (2018) The AIM2 inflammasome: sensor of pathogens and cellular perturbations. Immunol Rev 281:99\u2013114. https:\/\/doi.org\/10.1111\/imr.12618","journal-title":"Immunol Rev"},{"key":"4_CR69","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature07725","volume":"458","author":"V Hornung","year":"2009","unstructured":"Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514\u2013518. https:\/\/doi.org\/10.1038\/nature07725","journal-title":"Nature"},{"key":"4_CR70","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nature07710","volume":"458","author":"T Fernandes-Alnemri","year":"2009","unstructured":"Fernandes-Alnemri T, Yu J-W, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509\u2013513. https:\/\/doi.org\/10.1038\/nature07710","journal-title":"Nature"},{"key":"4_CR71","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","volume":"9","author":"N Kerur","year":"2011","unstructured":"Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B (2011) IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9:363\u2013375. https:\/\/doi.org\/10.1016\/j.chom.2011.04.008","journal-title":"Cell Host Microbe"},{"key":"4_CR72","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni.1932","volume":"11","author":"L Unterholzner","year":"2010","unstructured":"Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG (2010) IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11:997\u20131004. https:\/\/doi.org\/10.1038\/ni.1932","journal-title":"Nat Immunol"},{"key":"4_CR73","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nature08476","volume":"461","author":"H Ishikawa","year":"2009","unstructured":"Ishikawa H, Ma Z, Barber GN (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461:788\u2013792. https:\/\/doi.org\/10.1038\/nature08476","journal-title":"Nature"},{"key":"4_CR74","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature12306","volume":"498","author":"A Ablasser","year":"2013","unstructured":"Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, R\u00f6hl I, Hopfner K-P, Ludwig J, Hornung V (2013) cGAS produces a 2\u2032-5\u2032-linked cyclic dinucleotide second messenger that activates STING. Nature 498:380\u2013384. https:\/\/doi.org\/10.1038\/nature12306","journal-title":"Nature"},{"key":"4_CR75","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nature12862","volume":"505","author":"JW Schoggins","year":"2014","unstructured":"Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, Garc\u00eda-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM (2014) Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 505:691\u2013695. https:\/\/doi.org\/10.1038\/nature12862","journal-title":"Nature"},{"key":"4_CR76","doi-asserted-by":"publisher","first-page":"20842","DOI":"10.1073\/pnas.0911267106","volume":"106","author":"T Saitoh","year":"2009","unstructured":"Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci USA 106:20842\u201320846. https:\/\/doi.org\/10.1073\/pnas.0911267106","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR77","doi-asserted-by":"publisher","first-page":"8653","DOI":"10.1073\/pnas.0900850106","volume":"106","author":"W Sun","year":"2009","unstructured":"Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA 106:8653\u20138658. https:\/\/doi.org\/10.1073\/pnas.0900850106","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR78","doi-asserted-by":"publisher","unstructured":"Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu Y-T, Grishin NV, Chen ZJ (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347:aaa2630. https:\/\/doi.org\/10.1126\/science.aaa2630","DOI":"10.1126\/science.aaa2630"},{"key":"4_CR79","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature07317","volume":"455","author":"H Ishikawa","year":"2008","unstructured":"Ishikawa H, Barber GN (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674\u2013678. https:\/\/doi.org\/10.1038\/nature07317","journal-title":"Nature"},{"key":"4_CR80","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.chom.2015.05.005","volume":"17","author":"AC Collins","year":"2015","unstructured":"Collins AC, Cai H, Li T, Franco LH, Li X-D, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU (2015) Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis. Cell Host Microbe 17:820\u2013828. https:\/\/doi.org\/10.1016\/j.chom.2015.05.005","journal-title":"Cell Host Microbe"},{"key":"4_CR81","doi-asserted-by":"publisher","unstructured":"Woodward JJ, Iavarone AT, Portnoy DA (2010) c-di-AMP secreted by intracellular listeria monocytogenes activates a host type I interferon response. Science (80\u2013) 328:1703\u20131705. https:\/\/doi.org\/10.1126\/science.1189801","DOI":"10.1126\/science.1189801"},{"key":"4_CR82","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.cell.2017.09.034","volume":"171","author":"J Moretti","year":"2017","unstructured":"Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, Blander JM (2017) STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum. Cell 171:809\u2013823.e13. https:\/\/doi.org\/10.1016\/j.cell.2017.09.034","journal-title":"Cell"},{"key":"4_CR83","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/nature10429","volume":"478","author":"DL Burdette","year":"2011","unstructured":"Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478:515\u2013518. https:\/\/doi.org\/10.1038\/nature10429","journal-title":"Nature"},{"key":"4_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2005.10.011","volume":"118","author":"JS Orange","year":"2006","unstructured":"Orange JS, Ballas ZK (2006) Natural killer cells in human health and disease. Clin Immunol 118:1\u201310","journal-title":"Clin Immunol"},{"key":"4_CR85","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1056\/NEJM198906293202605","volume":"320","author":"CA Biron","year":"1989","unstructured":"Biron CA, Byron KS, Sullivan JL (1989) Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320:1731\u20131735","journal-title":"N Engl J Med"},{"key":"4_CR86","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S1286-4579(02)00038-2","volume":"4","author":"JS Orange","year":"2002","unstructured":"Orange JS (2002) Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect 4:1545\u20131558","journal-title":"Microbes Infect"},{"key":"4_CR87","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/nri1983","volume":"6","author":"I Voskoboinik","year":"2006","unstructured":"Voskoboinik I, Smyth MJ, Trapani JA (2006) Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol 6:940\u2013952","journal-title":"Nat Rev Immunol"},{"key":"4_CR88","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1002\/eji.200324070","volume":"33","author":"RP Wallin","year":"2003","unstructured":"Wallin RP, Screpanti V, Michaelsson J, Grandien A, Ljunggren HG (2003) Regulation of perforin-independent NK cell-mediated cytotoxicity. Eur J Immunol 33:2727\u20132735","journal-title":"Eur J Immunol"},{"key":"4_CR89","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","volume":"15","author":"U Boehm","year":"1997","unstructured":"Boehm U, Klamp T, Groot M, Howard JC (1997) Cellular responses to interferon-\u03b3. Ann Rev Immunol 15:749\u2013795","journal-title":"Ann Rev Immunol"},{"key":"4_CR90","doi-asserted-by":"publisher","first-page":"14151","DOI":"10.1073\/pnas.1835830100","volume":"100","author":"JS Orange","year":"2003","unstructured":"Orange JS, Harris KE, Andzelm MM, Valter MM, Geha RS, Strominger JL (2003) The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc Natl Acad Sci USA 100:14151\u201314156","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR91","doi-asserted-by":"publisher","first-page":"7767","DOI":"10.1073\/pnas.1336920100","volume":"100","author":"C Wulfing","year":"2003","unstructured":"Wulfing C, Purtic B, Klem J, Schatzle JD (2003) Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing. Proc Natl Acad Sci USA 100:7767\u20137772","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR92","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1600-065X.2006.00457.x","volume":"214","author":"YT Bryceson","year":"2006","unstructured":"Bryceson YT, March ME, Ljunggren HG, Long EO (2006) Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev 214:273\u2013291","journal-title":"Immunol Rev"},{"key":"4_CR93","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.4049\/jimmunol.128.6.2691","volume":"128","author":"O Carpen","year":"1982","unstructured":"Carpen O, Virtanen I, Saksela E (1982) Ultrastructure of human natural killer cells: nature of the cytolytic contacts in relation to cellular secretion. J Immunol 128:2691\u20132697","journal-title":"J Immunol"},{"key":"4_CR94","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.4049\/jimmunol.131.6.2695","volume":"131","author":"O Carpen","year":"1983","unstructured":"Carpen O, Virtanen I, Lehto VP, Saksela E (1983) Polarization of NK cell cytoskeleton upon conjugation with sensitive target cells. J Immunol 131:2695\u20132698","journal-title":"J Immunol"},{"key":"4_CR95","doi-asserted-by":"publisher","first-page":"7224","DOI":"10.1073\/pnas.80.23.7224","volume":"80","author":"A Kupfer","year":"1983","unstructured":"Kupfer A, Dennert G, Singer SJ (1983) Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. Proc Natl Acad Sci USA 80:7224\u20137228","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR96","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.smim.2004.09.007","volume":"17","author":"G Bossi","year":"2005","unstructured":"Bossi G, Griffiths GM (2005) CTL secretory lysosomes: biogenesis and secretion of a harmful organelle. Semin Immunol 17:87\u201394","journal-title":"Semin Immunol"},{"key":"4_CR97","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1084\/jem.190.7.1005","volume":"190","author":"M Eriksson","year":"1999","unstructured":"Eriksson M, Leitz G, Fallman E, Axner O, Ryan JC, Nakamura MC, Sentman CL (1999) Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets. J Exp Med 190:1005\u20131012","journal-title":"J Exp Med"},{"key":"4_CR98","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1084\/jem.20051143","volume":"202","author":"YT Bryceson","year":"2005","unstructured":"Bryceson YT, March ME, Barber DF, Ljunggren HG, Long EO (2005) Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J Exp Med 202:1001\u20131012","journal-title":"J Exp Med"},{"key":"4_CR99","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","volume":"31","author":"EO Long","year":"2013","unstructured":"Long EO, Kim HS, Liu D, Peterson ME, Rajagopalan S (2013) Controlling natural killer cell responses: integration of signals for activation and inhibition. Ann Rev Immunol 31:227\u2013258. https:\/\/doi.org\/10.1146\/annurev-immunol-020711-075005","journal-title":"Ann Rev Immunol"},{"key":"4_CR100","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/sj.emboj.7600019","volume":"23","author":"L Moretta","year":"2004","unstructured":"Moretta L, Moretta A (2004) Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J 23:255\u2013259. https:\/\/doi.org\/10.1038\/sj.emboj.7600019","journal-title":"EMBO J"},{"key":"4_CR101","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","volume":"23","author":"LL Lanier","year":"2005","unstructured":"Lanier LL (2005) NK cell recognition. Ann Rev Immunol 23:225\u2013274. https:\/\/doi.org\/10.1146\/annurev.immunol.23.021704.115526","journal-title":"Ann Rev Immunol"},{"key":"4_CR102","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","volume":"27","author":"JE Smith-Garvin","year":"2009","unstructured":"Smith-Garvin JE, Koretzky GA, Jordan MS (2009) T cell activation. Ann Rev Immunol 27:591\u2013619. https:\/\/doi.org\/10.1146\/annurev.immunol.021908.132706","journal-title":"Ann Rev Immunol"},{"key":"4_CR103","doi-asserted-by":"publisher","unstructured":"Kim HS, Long EO (2012) Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells. Sci Signal 5:ra49. https:\/\/doi.org\/10.1126\/scisignal.2002754","DOI":"10.1126\/scisignal.2002754"},{"key":"4_CR104","doi-asserted-by":"crossref","unstructured":"Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (1999) An activating immunoreceptor complex formed by NKG2D and DAP10. Science (80\u2013) 285:730\u2013732","DOI":"10.1126\/science.285.5428.730"},{"key":"4_CR105","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/ni857","volume":"3","author":"S Gilfillan","year":"2002","unstructured":"Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M (2002) NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol 3:1150\u20131155. https:\/\/doi.org\/10.1038\/ni857","journal-title":"Nat Immunol"},{"key":"4_CR106","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/ni929","volume":"4","author":"DD Billadeau","year":"2003","unstructured":"Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ (2003) NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat Immunol 4:557\u2013564. https:\/\/doi.org\/10.1038\/ni929","journal-title":"Nat Immunol"},{"key":"4_CR107","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.4049\/jimmunol.177.4.2349","volume":"177","author":"DB Graham","year":"2006","unstructured":"Graham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppel T, Brim K, Takai T, Shaw AS, Colonna M, Swat W (2006) Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J Immunol 177:2349\u20132355","journal-title":"J Immunol"},{"key":"4_CR108","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/ni1325","volume":"7","author":"JL Upshaw","year":"2006","unstructured":"Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ (2006) NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat Immunol 7:524\u2013532. https:\/\/doi.org\/10.1038\/ni1325","journal-title":"Nat Immunol"},{"key":"4_CR109","doi-asserted-by":"publisher","first-page":"6933","DOI":"10.4049\/jimmunol.0803840","volume":"182","author":"CM Segovis","year":"2009","unstructured":"Segovis CM, Schoon RA, Dick CJ, Nacusi LP, Leibson PJ, Billadeau DD (2009) PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion. J Immunol 182:6933\u20136942. https:\/\/doi.org\/10.4049\/jimmunol.0803840","journal-title":"J Immunol"},{"key":"4_CR110","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1600-065X.2006.00453.x","volume":"214","author":"A Veillette","year":"2006","unstructured":"Veillette A (2006) NK cell regulation by SLAM family receptors and SAP-related adapters. Immunol Rev 214:22\u201334. https:\/\/doi.org\/10.1111\/j.1600-065X.2006.00453.x","journal-title":"Immunol Rev"},{"key":"4_CR111","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/ni.1763","volume":"10","author":"Z Dong","year":"2009","unstructured":"Dong Z, Cruz-Munoz ME, Zhong MC, Chen R, Latour S, Veillette A (2009) Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat Immunol 10:973\u2013980. https:\/\/doi.org\/10.1038\/ni.1763","journal-title":"Nat Immunol"},{"key":"4_CR112","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S1074-7613(00)80136-3","volume":"11","author":"K Shibuya","year":"1999","unstructured":"Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A (1999) Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity 11:615\u2013623","journal-title":"Immunity"},{"key":"4_CR113","doi-asserted-by":"publisher","first-page":"657","DOI":"10.4049\/jimmunol.0904117","volume":"186","author":"KM Dennehy","year":"2011","unstructured":"Dennehy KM, Klimosch SN, Steinle A (2011) Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity. J Immunol 186:657\u2013661. https:\/\/doi.org\/10.4049\/jimmunol.0904117","journal-title":"J Immunol"},{"key":"4_CR114","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1074\/jbc.M608524200","volume":"282","author":"SM Nurmi","year":"2007","unstructured":"Nurmi SM, Autero M, Raunio AK, Gahmberg CG, Fagerholm SC (2007) Phosphorylation of the LFA-1 integrin beta2-chain on Thr-758 leads to adhesion, Rac-1\/Cdc42 activation, and stimulation of CD69 expression in human T cells. J Biol Chem 282:968\u2013975","journal-title":"J Biol Chem"},{"key":"4_CR115","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.4049\/jimmunol.1002438","volume":"186","author":"ME March","year":"2011","unstructured":"March ME, Long EO (2011) beta2 integrin induces TCRzeta-Syk-phospholipase C-gamma phosphorylation and paxillin-dependent granule polarization in human NK cells. J Immunol 186:2998\u20133005. https:\/\/doi.org\/10.4049\/jimmunol.1002438","journal-title":"J Immunol"},{"key":"4_CR116","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1084\/jem.20021995","volume":"198","author":"B Riteau","year":"2003","unstructured":"Riteau B, Barber DF, Long EO (2003) Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. J Exp Med 198:469\u2013474","journal-title":"J Exp Med"},{"key":"4_CR117","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.1128\/MCB.23.17.6291-6299.2003","volume":"23","author":"CC Stebbins","year":"2003","unstructured":"Stebbins CC, Watzl C, Billadeau DD, Leibson PJ, Burshtyn DN, Long EO (2003) Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol 23:6291\u20136299","journal-title":"Mol Cell Biol"},{"key":"4_CR118","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.4049\/jimmunol.167.8.4358","volume":"167","author":"YM Vyas","year":"2001","unstructured":"Vyas YM, Mehta KM, Morgan M, Maniar H, Butros L, Jung S, Burkhardt JK, Dupont B (2001) Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions. J Immunol 167:4358\u20134367","journal-title":"J Immunol"},{"key":"4_CR119","doi-asserted-by":"publisher","first-page":"3150","DOI":"10.4049\/jimmunol.168.7.3150","volume":"168","author":"YM Vyas","year":"2002","unstructured":"Vyas YM, Maniar H, Dupont B (2002) Cutting edge: differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions. J Immunol 168:3150\u20133154","journal-title":"J Immunol"},{"key":"4_CR120","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.4049\/jimmunol.170.6.2862","volume":"170","author":"FE McCann","year":"2003","unstructured":"McCann FE, Vanherberghen B, Eleme K, Carlin LM, Newsam RJ, Goulding D, Davis DM (2003) The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. J Immunol 170:2862\u20132870","journal-title":"J Immunol"},{"key":"4_CR121","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/eji.1830270517","volume":"27","author":"V Braud","year":"1997","unstructured":"Braud V, Jones EY, McMichael A (1997) The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur J Immunol 27:1164\u20131169","journal-title":"Eur J Immunol"},{"key":"4_CR122","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S1074-7613(00)80393-3","volume":"7","author":"NM Valiante","year":"1997","unstructured":"Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D\u2019Andrea A, Phillips JH, Lanier LL, Parham P (1997) Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 7:739\u2013751","journal-title":"Immunity"},{"key":"4_CR123","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nri1570","volume":"5","author":"P Parham","year":"2005","unstructured":"Parham P (2005) MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5:201\u2013214","journal-title":"Nat Rev Immunol"},{"key":"4_CR124","doi-asserted-by":"crossref","unstructured":"MacFarlane AW 4th, Campbell KS (2006) Signal transduction in natural killer cells. Curr Top Microbiol Immunol 298:23\u201357","DOI":"10.1007\/3-540-27743-9_2"},{"key":"4_CR125","doi-asserted-by":"publisher","first-page":"27518","DOI":"10.1074\/jbc.273.42.27518","volume":"273","author":"BA Binstadt","year":"1998","unstructured":"Binstadt BA, Billadeau DD, Jevremovic D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ (1998) SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem 273:27518\u201327523","journal-title":"J Biol Chem"},{"key":"4_CR126","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.immuni.2008.07.014","volume":"29","author":"ME Peterson","year":"2008","unstructured":"Peterson ME, Long EO (2008) Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Immunity 29:578\u2013588. https:\/\/doi.org\/10.1016\/j.immuni.2008.07.014","journal-title":"Immunity"},{"key":"4_CR127","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.immuni.2012.03.007","volume":"36","author":"D Liu","year":"2012","unstructured":"Liu D, Peterson ME, Long EO (2012) The adaptor protein Crk controls activation and inhibition of natural killer cells. Immunity 36:600\u2013611. https:\/\/doi.org\/10.1016\/j.immuni.2012.03.007","journal-title":"Immunity"},{"key":"4_CR128","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, Karre K (1990) In search of the \u201cmissing self\u201d: MHC molecules and NK cell recognition. Immunol Today 11:237\u2013244","journal-title":"Immunol Today"},{"key":"4_CR129","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.4049\/jimmunol.177.10.6904","volume":"177","author":"CR Almeida","year":"2006","unstructured":"Almeida CR, Davis DM (2006) Segregation of HLA-C from ICAM-1 at NK cell immune synapses is controlled by its cell surface density. J Immunol 177:6904\u20136910","journal-title":"J Immunol"},{"key":"4_CR130","doi-asserted-by":"publisher","first-page":"760","DOI":"10.4049\/jimmunol.1002208","volume":"187","author":"A Kaplan","year":"2011","unstructured":"Kaplan A, Kotzer S, Almeida CR, Kohen R, Halpert G, Salmon-Divon M, Kohler K, Hoglund P, Davis DM, Mehr R (2011) Simulations of the NK cell immune synapse reveal that activation thresholds can be established by inhibitory receptors acting locally. J Immunol 187:760\u2013773. https:\/\/doi.org\/10.4049\/jimmunol.1002208","journal-title":"J Immunol"},{"key":"4_CR131","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.4049\/jimmunol.178.9.5606","volume":"178","author":"J Endt","year":"2007","unstructured":"Endt J, McCann FE, Almeida CR, Urlaub D, Leung R, Pende D, Davis DM, Watzl C (2007) Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse. J Immunol 178:5606\u20135611","journal-title":"J Immunol"},{"key":"4_CR132","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1016\/j.celrep.2016.04.075","volume":"15","author":"A Oszmiana","year":"2016","unstructured":"Oszmiana A, Williamson DJ, Cordoba SP, Morgan DJ, Kennedy PR, Stacey K, Davis DM (2016) The size of activating and inhibitory killer Ig-like receptor nanoclusters is controlled by the transmembrane sequence and affects signaling. Cell Rep 15:1957\u20131972. https:\/\/doi.org\/10.1016\/j.celrep.2016.04.075","journal-title":"Cell Rep"},{"key":"4_CR133","doi-asserted-by":"publisher","unstructured":"von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku C-L, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang H-H, Janniere L, Rose Y, Garty B-Z, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova J-L (2008) Pyogenic Bacterial Infections in humans with MyD88 deficiency. Science (80\u2013) 321:691\u2013696. https:\/\/doi.org\/10.1126\/science.1158298","DOI":"10.1126\/science.1158298"},{"key":"4_CR134","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1084\/jem.20031220","volume":"198","author":"TR Hawn","year":"2003","unstructured":"Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires\u2019 disease. J Exp Med 198:1563\u20131572. https:\/\/doi.org\/10.1084\/jem.20031220","journal-title":"J Exp Med"},{"key":"4_CR135","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1001\/archinte.162.9.1028","volume":"162","author":"E Lorenz","year":"2002","unstructured":"Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162:1028\u20131032","journal-title":"Arch Intern Med"},{"key":"4_CR136","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1056\/NEJMoa0901053","volume":"361","author":"B Ferwerda","year":"2009","unstructured":"Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, Jacobs L, Jansen T, Verheijen K, Masthoff L, Morr\u00e9 SA, Vriend G, Williams DL, Perfect JR, Joosten LAB, Wijmenga C, van der Meer JWM, Adema GJ, Kullberg BJ, Brown GD, Netea MG (2009) Human Dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 361:1760\u20131767. https:\/\/doi.org\/10.1056\/NEJMoa0901053","journal-title":"N Engl J Med"},{"key":"4_CR137","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1056\/NEJMoa0810719","volume":"361","author":"E-O Glocker","year":"2009","unstructured":"Glocker E-O, Hennigs A, Nabavi M, Sch\u00e4ffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschl\u00e4ger N, Gross O, Ruland J, Grimbacher B (2009) A Homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med 361:1727\u20131735. https:\/\/doi.org\/10.1056\/NEJMoa0810719","journal-title":"N Engl J Med"},{"key":"4_CR138","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/ng756","volume":"29","author":"HM Hoffman","year":"2001","unstructured":"Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29:301\u2013305. https:\/\/doi.org\/10.1038\/ng756","journal-title":"Nat Genet"},{"key":"4_CR139","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1002\/art.10688","volume":"46","author":"I Aksentijevich","year":"2002","unstructured":"Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, Stein L, Russo R, Goldsmith D, Dent P, Rosenberg HF, Austin F, Remmers EF, Balow JE, Rosenzweig S, Komarow H, Shoham NG, Wood G, Jones J, Mangra N, Carrero H, Adams BS, Moore TL, Schikler K, Hoffman H, Lovell DJ, Lipnick R, Barron K, O\u2019Shea JJ, Kastner DL, Goldbach-Mansky R (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum 46:3340\u20133348. https:\/\/doi.org\/10.1002\/art.10688","journal-title":"Arthritis Rheum"},{"key":"4_CR140","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1002\/art.10509","volume":"46","author":"E Aganna","year":"2002","unstructured":"Aganna E, Martinon F, Hawkins PN, Ross JB, Swan DC, Booth DR, Lachmann HJ, Bybee A, Gaudet R, Woo P, Feighery C, Cotter FE, Thome M, Hitman GA, Tschopp J, McDermott MF (2002) Association of mutations in the NALP3\/CIAS1\/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 46:2445\u20132452. https:\/\/doi.org\/10.1002\/art.10509","journal-title":"Arthritis Rheum"},{"key":"4_CR141","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1084\/jem.20161596","volume":"213","author":"MP Rodero","year":"2016","unstructured":"Rodero MP, Crow YJ (2016) Type I interferon-mediated monogenic autoinflammation: the type I interferonopathies, a conceptual overview. J Exp Med 213:2527\u20132538. https:\/\/doi.org\/10.1084\/jem.20161596","journal-title":"J Exp Med"},{"key":"4_CR142","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1056\/NEJMoa1312625","volume":"371","author":"Y Liu","year":"2014","unstructured":"Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Goldbach-Mansky R et al (2014) Activated STING in a vascular and pulmonary syndrome. N Engl J Med 371:507\u2013518. https:\/\/doi.org\/10.1056\/NEJMoa1312625","journal-title":"N Engl J Med"},{"key":"4_CR143","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar J-P, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nu\u00f1ez G, Cho JH (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease. Nature 411:603\u2013606. https:\/\/doi.org\/10.1038\/35079114","journal-title":"Nature"},{"key":"4_CR144","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"J-P Hugot","year":"2001","unstructured":"Hugot J-P, Chamaillard M, Zouali H, Lesage S, C\u00e9zard J-P, Belaiche J, Almer S, Tysk C, O\u2019Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel J-F, Sahbatou M, Thomas G (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease. Nature 411:599\u2013603. https:\/\/doi.org\/10.1038\/35079107","journal-title":"Nature"},{"key":"4_CR145","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1093\/hmg\/ddi135","volume":"14","author":"DPB McGovern","year":"2005","unstructured":"McGovern DPB, Hysi P, Ahmad T, van Heel DA, Moffatt MF, Carey A, Cookson WOC, Jewell DP (2005) Association between a complex insertion\/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease. Hum Mol Genet 14:1245\u20131250. https:\/\/doi.org\/10.1093\/hmg\/ddi135","journal-title":"Hum Mol Genet"},{"key":"4_CR146","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jaci.2013.07.020","volume":"132","author":"JS Orange","year":"2014","unstructured":"Orange JS (2014) Natural killer cell deficiency. J Allergy Clin Immunol 132:515\u2013525. https:\/\/doi.org\/10.1016\/j.jaci.2013.07.020","journal-title":"J Allergy Clin Immunol"},{"key":"4_CR147","doi-asserted-by":"publisher","first-page":"11351","DOI":"10.1073\/pnas.162376099","volume":"99","author":"JS Orange","year":"2002","unstructured":"Orange JS, Ramesh N, Remold-O\u2019Donnell E, Sasahara Y, Koopman L, Byrne M, Bonilla FA, Rosen FS, Geha RS, Strominger JL (2002) Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci 99:11351\u201311356. https:\/\/doi.org\/10.1073\/pnas.162376099","journal-title":"Proc Natl Acad Sci"},{"key":"4_CR148","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1084\/jem.20110896","volume":"209","author":"G Lanzi","year":"2012","unstructured":"Lanzi G, Moratto D, Vairo D, Masneri S, Delmonte O, Paganini T, Parolini S, Tabellini G, Mazza C, Savoldi G, Montin D, Martino S, Tovo P, Pessach IM, Massaad MJ, Ramesh N, Porta F, Plebani A, Notarangelo LD, Geha RS, Giliani S (2012) A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. J Exp Med 209:29\u201334. https:\/\/doi.org\/10.1084\/jem.20110896","journal-title":"J Exp Med"},{"key":"4_CR149","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fimmu.2018.00445","volume":"9","author":"EM Mace","year":"2018","unstructured":"Mace EM (2018) Phosphoinositide-3-kinase signaling in human natural killer cells: new insights from primary immunodeficiency. Front Immunol 9:7\u201310. https:\/\/doi.org\/10.3389\/fimmu.2018.00445","journal-title":"Front Immunol"},{"key":"4_CR150","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ni.2771","volume":"15","author":"CL Lucas","year":"2014","unstructured":"Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G (2014) Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110\u03b4 result in T cell senescence and human immunodeficiency. Nat Immunol 15:88\u201397. https:\/\/doi.org\/10.1038\/ni.2771","journal-title":"Nat Immunol"},{"key":"4_CR151","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1126\/science.1243292","volume":"342","author":"I Angulo","year":"2013","unstructured":"Angulo I, Vadas O, Gar\u00e7on F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debr\u00e9 M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S (2013) Phosphoinositide 3-kinase \u03b4 gene mutation predisposes to respiratory infection and airway damage. Science 342:866\u2013871. https:\/\/doi.org\/10.1126\/science.1243292","journal-title":"Science"},{"key":"4_CR152","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jaci.2017.11.042","volume":"142","author":"R Ruiz-Garc\u00eda","year":"2018","unstructured":"Ruiz-Garc\u00eda R, Vargas-Hern\u00e1ndez A, Chinn IK, Angelo LS, Cao TN, Coban-Akdemir Z, Jhangiani SN, Meng Q, Forbes LR, Muzny DM, Allende LM, Ehlayel MS, Gibbs RA, Lupski JR, Uzel G, Orange JS, Mace EM (2018) Mutations in PI3K110\u03b4 cause impaired natural killer cell function partially rescued by rapamycin treatment. J Allergy Clin Immunol 142:605\u2013617.e7. https:\/\/doi.org\/10.1016\/j.jaci.2017.11.042","journal-title":"J Allergy Clin Immunol"},{"key":"4_CR153","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.4049\/jimmunol.165.7.3549","volume":"165","author":"L Benoit","year":"2000","unstructured":"Benoit L, Wang X, Pabst HF, Dutz J, Tan R (2000) Defective NK cell activation in X-linked lymphoproliferative disease. J Immunol 165:3549\u20133553","journal-title":"J Immunol"}],"container-title":["Tissue-Specific Cell Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-44436-5_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T11:11:00Z","timestamp":1701429060000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-44436-5_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030444358","9783030444365"],"references-count":153,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-44436-5_4","relation":{},"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"30 May 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}