{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:25:29Z","timestamp":1763706329053,"version":"3.40.3"},"publisher-location":"Cham","reference-count":40,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783031040382"},{"type":"electronic","value":"9783031040399"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-04039-9_10","type":"book-chapter","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T21:04:45Z","timestamp":1656363885000},"page":"259-273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biosensors Advances: Contributions to Cancer Diagnostics and Treatment"],"prefix":"10.1007","author":[{"given":"Ana I.","family":"Barbosa","sequence":"first","affiliation":[]},{"given":"Rita","family":"Rebelo","sequence":"additional","affiliation":[]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Vitor M.","family":"Correlo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"e609","DOI":"10.1016\/S2214-109X(16)30143-7","volume":"4","author":"M Plummer","year":"2016","unstructured":"Plummer M, de Martel C, Vignat J, Ferlay J, Bray F, Franceschi S (2016) Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Heal 4:e609\u2013e616. https:\/\/doi.org\/10.1016\/S2214-109X(16)30143-7","journal-title":"Lancet Glob Heal"},{"key":"10_CR2","unstructured":"N.I. of H. (US), B.S.C. Study, Understanding Cancer (2007) https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK20362\/. Accessed 27 Oct 2020"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0140-6736(10)62231-3","volume":"377","author":"MP Coleman","year":"2011","unstructured":"Coleman MP, Forman D, Bryant H, Butler J, Rachet B, Maringe C, Nur U, Tracey E, Coory M, Hatcher J, McGahan CE, Turner D, Marrett L, Gjerstorff ML, Johannesen TB, Adolfsson J, Lambe M, Lawrence G, Meechan D, Morris EJ, Middleton R, Steward J, Richards MA (2011) Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995\u20132007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data. Lancet 377:127\u2013138. https:\/\/doi.org\/10.1016\/S0140-6736(10)62231-3","journal-title":"Lancet"},{"key":"10_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l408","volume":"364","author":"N Hawkes","year":"2019","unstructured":"Hawkes N (2019) Cancer survival data emphasise importance of early diagnosis. BMJ 364:l408. https:\/\/doi.org\/10.1136\/bmj.l408","journal-title":"BMJ"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1177\/0272989X10396717","volume":"31","author":"EM Wever","year":"2011","unstructured":"Wever EM, Draisma G, Heijnsdijk EAM, De Koning HJ (2011) How does early detection by screening affect disease progression?: Modeling estimated benefits in prostate cancer screening. Med Decis Mak 31:550\u2013558. https:\/\/doi.org\/10.1177\/0272989X10396717","journal-title":"Med Decis Mak"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/b978-0-12-818128-7.00026-5","volume-title":"Biomater 3D tumor model","author":"R Rebelo","year":"2020","unstructured":"Rebelo R, Barbosa AI, Kundu SC, Reis RL, Correlo VM (2020) Biodetection and sensing for cancer diagnostics. In: Biomater 3D tumor model. Elsevier, pp 643\u2013660. https:\/\/doi.org\/10.1016\/b978-0-12-818128-7.00026-5"},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.7150\/jca.8016","volume":"5","author":"EJ Schneble","year":"2014","unstructured":"Schneble EJ, Graham LJ, Shupe MP, Flynt FL, Banks KP, Kirkpatrick AD, Nissan A, Henry L, Stojadinovic A, Shumway NM, Peoples GE, Setlik RF (2014) Current approaches and challenges in early detection of breast cancer recurrence. J Cancer 5:281\u2013290. https:\/\/doi.org\/10.7150\/jca.8016","journal-title":"J Cancer"},{"key":"10_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/20014091084218","volume":"38","author":"MJ Duffy","year":"2001","unstructured":"Duffy MJ (2001) Clinical uses of tumor markers: a critical review. Crit Rev Clin Lab Sci 38:225\u2013262. https:\/\/doi.org\/10.1080\/20014091084218","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10_CR9","doi-asserted-by":"publisher","unstructured":"Larrea E, Sole C, Manterola L, Goicoechea I, Armesto M, Arestin M, Caffarel MM, Araujo AM, Araiz M, Fernandez-Mercado M, Lawrie CH (2016) New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies. Int J Mol Sci 17. https:\/\/doi.org\/10.3390\/ijms17050627","DOI":"10.3390\/ijms17050627"},{"key":"10_CR10","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nrc1478","volume":"4","author":"RA Gatenby","year":"2004","unstructured":"Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891\u2013899. https:\/\/doi.org\/10.1038\/nrc1478","journal-title":"Nat Rev Cancer"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"45759","DOI":"10.18632\/oncotarget.17404","volume":"8","author":"M Chen","year":"2017","unstructured":"Chen M, Chen C, Shen Z, Zhang X, Chen Y, Lin F, Ma X, Zhuang C, Mao Y, Gan H, Chen P, Zong X, Wu R (2017) Extracellular pH is a biomarker enabling detection of breast cancer and liver cancer using CEST MRI. Oncotarget 8:45759\u201345767. https:\/\/doi.org\/10.18632\/oncotarget.17404","journal-title":"Oncotarget"},{"key":"10_CR12","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1158\/0008-5472.CAN-12-2796","volume":"73","author":"V Estrella","year":"2013","unstructured":"Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ (2013) Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 73:1524\u20131535. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-2796","journal-title":"Cancer Res"},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/BF00121214","volume":"14","author":"R Mart\u00ednez-Zaguil\u00e1n","year":"1996","unstructured":"Mart\u00ednez-Zaguil\u00e1n R, Seftor EA, Seftor RE, Chu YW, Gillies RJ, Hendrix MJ (1996) Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis 14:176\u2013186. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8605731. Accessed 28 May 2019","journal-title":"Clin Exp Metastasis"},{"key":"10_CR14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mee.2014.09.024","volume":"132","author":"W Jung","year":"2015","unstructured":"Jung W, Han J, Choi JW, Ahn CH (2015) Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies. Microelectron Eng 132:46\u201357. https:\/\/doi.org\/10.1016\/j.mee.2014.09.024","journal-title":"Microelectron Eng"},{"key":"10_CR15","doi-asserted-by":"publisher","unstructured":"Chin CD, Linder V, Sia SK (2012) Commercialization of microfluidic point-of-care diagnostic devices. Lab Chip:2118\u20132134. https:\/\/doi.org\/10.1039\/c2lc21204h","DOI":"10.1039\/c2lc21204h"},{"key":"10_CR16","volume-title":"Biomater. 3D tumor model","author":"R Rebelo","year":"2020","unstructured":"Rebelo R, Barbosa A, Reis R, Correlo V (2020) Bio-detection and sensing for cancer diagnostics. In: Kundu S, Reis RL (eds) Biomater. 3D tumor model, 1st edn","edition":"1"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1039\/c6an02445a","volume":"142","author":"AI Barbosa","year":"2017","unstructured":"Barbosa AI, Reis NM (2017) A critical insight into the development pipeline of microfluidic immunoassay devices for the sensitive quantitation of protein biomarkers at the point of care. Analyst 142:858\u2013882. https:\/\/doi.org\/10.1039\/c6an02445a","journal-title":"Analyst"},{"key":"10_CR18","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jpha.2018.12.001","volume":"9","author":"P Cui","year":"2019","unstructured":"Cui P, Wang S (2019) Application of microfluidic chip technology in pharmaceutical analysis: a review. J Pharm Anal 9:238\u2013247. https:\/\/doi.org\/10.1016\/j.jpha.2018.12.001","journal-title":"J Pharm Anal"},{"key":"10_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/bios10020011","volume":"10","author":"BG Andryukov","year":"2020","unstructured":"Andryukov BG, Besednova NN, Romashko RV, Zaporozhets TS, Efimov TA (2020) Label-free biosensors for laboratory-based diagnostics of infections: current achievements and new trends. Biosensors 10:690041. https:\/\/doi.org\/10.3390\/bios10020011","journal-title":"Biosensors"},{"key":"10_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.apsusc.2017.09.162","volume":"438","author":"MS Rodrigues","year":"2018","unstructured":"Rodrigues MS, Costa D, Domingues RP, Apreutesei M, Pedrosa P, Martin N, Correlo VM, Reis RL, Alves E, Barradas NP, Sampaio P, Borges J, Vaz F (2018) Optimization of nanocomposite Au\/TiO 2 thin films towards LSPR optical-sensing. Appl Surf Sci 438:74\u201383. https:\/\/doi.org\/10.1016\/j.apsusc.2017.09.162","journal-title":"Appl Surf Sci"},{"key":"10_CR21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.msec.2019.03.029","volume":"100","author":"AI Barbosa","year":"2019","unstructured":"Barbosa AI, Borges J, Meira DI, Costa D, Rodrigues MS, Rebelo R, Correlo VM, Vaz F, Reis RL (2019) Development of label-free plasmonic Au-TiO2 thin film immunosensor devices. Mater Sci Eng C 100:424\u2013432. https:\/\/doi.org\/10.1016\/j.msec.2019.03.029","journal-title":"Mater Sci Eng C"},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1039\/D0MA00163E","volume":"1","author":"S Abalde-Cel","year":"2020","unstructured":"Abalde-Cel S, Rebelo R, Wu L, Barbosa AI, Rodr\u00edguez-Lorenzo L, Krishna Kant RLR, Correlo VM, Di\u00e9guez L (2020) A SERS-based 3D nanobiosensor: towards cell metabolite monitoring. Mater Adv 1:1613\u20131621. https:\/\/doi.org\/10.1039\/D0MA00163E","journal-title":"Mater Adv"},{"key":"10_CR23","doi-asserted-by":"publisher","first-page":"11812","DOI":"10.1038\/s41598-018-30180-8","volume":"8","author":"CY Chang","year":"2018","unstructured":"Chang CY, Lin HT, Lai MS, Shieh TY, Peng CC, Shih MH, Tung YC (2018) Flexible localized surface plasmon resonance sensor with metal\u2013insulator\u2013metal nanodisks on PDMS substrate. Sci Rep 8:11812. https:\/\/doi.org\/10.1038\/s41598-018-30180-8","journal-title":"Sci Rep"},{"key":"10_CR24","doi-asserted-by":"publisher","first-page":"5561","DOI":"10.3390\/s110605561","volume":"11","author":"A Darwish","year":"2011","unstructured":"Darwish A, Hassanien AE (2011) Wearable and implantable wireless sensor network solutions for healthcare monitoring. Sensors (Basel) 11:5561\u20135595. https:\/\/doi.org\/10.3390\/s110605561","journal-title":"Sensors (Basel)"},{"key":"10_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/bios10070079","volume":"10","author":"D Rodrigues","year":"2020","unstructured":"Rodrigues D, Barbosa AI, Rebelo R, Kwon IK, Reis RL, Correlo VM (2020) Skin-integrated wearable systems and implantable biosensors: a comprehensive review. Biosensors 10:79. https:\/\/doi.org\/10.3390\/bios10070079","journal-title":"Biosensors"},{"key":"10_CR26","doi-asserted-by":"publisher","first-page":"9614","DOI":"10.1021\/acsnano.7b04898","volume":"11","author":"Y Liu","year":"2017","unstructured":"Liu Y, Pharr M, Salvatore GA (2017) Lab-on-skin: a review of flexible and stretchable electronics for wearable health monitoring. ACS Nano 11:9614\u20139635. https:\/\/doi.org\/10.1021\/acsnano.7b04898","journal-title":"ACS Nano"},{"key":"10_CR27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1039\/c7lc00914c","volume":"18","author":"J Heikenfeld","year":"2018","unstructured":"Heikenfeld J, Jajack A, Rogers J, Gutruf P, Tian L, Pan T, Li R, Khine M, Kim J, Wang J, Kim J (2018) Wearable sensors: modalities, challenges, and prospects. Lab Chip 18:217\u2013248. https:\/\/doi.org\/10.1039\/c7lc00914c","journal-title":"Lab Chip"},{"key":"10_CR28","doi-asserted-by":"publisher","unstructured":"Gonzales WV, Mobashsher AT, Abbosh A (2019) The progress of glucose monitoring\u2014a review of invasive to minimally and non-invasive techniques, devices and sensors. Sensors 19. https:\/\/doi.org\/10.3390\/s19040800","DOI":"10.3390\/s19040800"},{"key":"10_CR29","doi-asserted-by":"publisher","first-page":"13720","DOI":"10.1038\/s41598-019-49689-7","volume":"9","author":"ME Payne","year":"2019","unstructured":"Payne ME, Zamarayeva A, Pister VI, Yamamoto NAD, Arias AC (2019) Printed, flexible lactate sensors: design considerations before performing on-body measurements. Sci Rep 9:13720. https:\/\/doi.org\/10.1038\/s41598-019-49689-7","journal-title":"Sci Rep"},{"key":"10_CR30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.tvjl.2018.07.011","volume":"239","author":"M Gray","year":"2018","unstructured":"Gray M, Meehan J, Ward C, Langdon SP, Kunkler IH, Murray A, Argyle D (2018) Implantable biosensors and their contribution to the future of precision medicine. Vet J 239:21\u201329. https:\/\/doi.org\/10.1016\/j.tvjl.2018.07.011","journal-title":"Vet J"},{"key":"10_CR31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bios.2018.12.057","volume":"130","author":"R Rebelo","year":"2019","unstructured":"Rebelo R, Barbosa AI, Caballero D, Kwon IK, Oliveira JM, Kundu SC, Reis RL, Correlo VM (2019) 3D biosensors in advanced medical diagnostics of high mortality diseases. Biosens Bioelectron 130:20\u201339. https:\/\/doi.org\/10.1016\/j.bios.2018.12.057","journal-title":"Biosens Bioelectron"},{"key":"10_CR32","doi-asserted-by":"publisher","unstructured":"Cadei A, Dionisi A, Sardini E, Serpelloni M (2014) Kinetic and thermal energy harvesters for implantable medical devices and biomedical autonomous sensors. Meas Sci Technol 25. https:\/\/doi.org\/10.1088\/0957-0233\/25\/1\/012003","DOI":"10.1088\/0957-0233\/25\/1\/012003"},{"key":"10_CR33","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cjca.2018.01.003","volume":"34","author":"CC Cheung","year":"2018","unstructured":"Cheung CC, Deyell MW (2018) Remote monitoring of cardiac implantable electronic devices. Can J Cardiol 34:941\u2013944. https:\/\/doi.org\/10.1016\/j.cjca.2018.01.003","journal-title":"Can J Cardiol"},{"key":"10_CR34","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/jbm.b.34254","volume":"107","author":"ME Gray","year":"2019","unstructured":"Gray ME, Meehan J, Blair EO, Ward C, Langdon SP, Morrison LR, Marland JRK, Tsiamis A, Kunkler IH, Murray A, Argyle D (2019) Biocompatibility of common implantable sensor materials in a tumor xenograft model. J Biomed Mater Res Part B Appl Biomater 107:1620\u20131633. https:\/\/doi.org\/10.1002\/jbm.b.34254","journal-title":"J Biomed Mater Res Part B Appl Biomater"},{"issue":"4","key":"10_CR35","doi-asserted-by":"publisher","first-page":"eaaq1090","DOI":"10.1126\/sciadv.aaq1090","volume":"4","author":"RM Williams","year":"2018","unstructured":"Williams RM, Lee C, Galassi TV, Harvey JD, Leicher R, Sirenko M, Dorso MA, Shah J, Olvera N, Dao F, Levine DA, Heller DA (2018) Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant. Sci Adv 4(4):eaaq1090","journal-title":"Sci Adv"},{"key":"10_CR36","unstructured":"National Library of Medicine, Cancer Biosensors Clinical Trials (2021) https:\/\/clinicaltrials.gov\/ct2\/results?cond=Cancer&term=biosensor&cntry=&state=&city=&dist=)"},{"key":"10_CR37","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s13045-019-0833-3","volume":"12","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Li M, Gao X, Chen Y, Liu T (2019) Nanotechnology in cancer diagnosis: progress, challenges and opportunities. J Hematol Oncol 12:137. https:\/\/doi.org\/10.1186\/s13045-019-0833-3","journal-title":"J Hematol Oncol"},{"key":"10_CR38","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.3389\/fbioe.2016.00011","volume":"4","author":"M Ming","year":"2016","unstructured":"Ming M, Wei Y, Senthilkumaran B, Vigneshvar S, Sudhakumari CC, Prakash H (2016) Recent advances in biosensor technology for potential applications\u2014an overview. Front Bioeng Biotechnol 4:3389\u20133311. https:\/\/doi.org\/10.3389\/fbioe.2016.00011","journal-title":"Front Bioeng Biotechnol"},{"key":"10_CR39","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1021\/acs.analchem.6b04251","volume":"89","author":"RJ Soto","year":"2017","unstructured":"Soto RJ, Hall JR, Brown MD, Taylor JB, Schoenfisch MH (2017) In vivo chemical sensors: role of biocompatibility on performance and utility. Anal Chem 89:276\u2013299. https:\/\/doi.org\/10.1021\/acs.analchem.6b04251","journal-title":"Anal Chem"},{"key":"10_CR40","doi-asserted-by":"publisher","first-page":"xvii","DOI":"10.1016\/B978-1-84569-935-2.50016-4","volume-title":"Biosensors for medical applications","author":"SPJ Higson","year":"2012","unstructured":"Higson SPJ (2012) Introduction to biosensors. In: Biosensors for medical applications, pp xvii\u2013xviii. https:\/\/doi.org\/10.1016\/B978-1-84569-935-2.50016-4"}],"container-title":["Advances in Experimental Medicine and Biology","Microfluidics and Biosensors in Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-04039-9_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T08:08:18Z","timestamp":1660378098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-04039-9_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031040382","9783031040399"],"references-count":40,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-04039-9_10","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"28 June 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}