{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:38:01Z","timestamp":1763141881996,"version":"3.40.3"},"publisher-location":"Cham","reference-count":142,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783031049415"},{"type":"electronic","value":"9783031049422"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-04942-2_10","type":"book-chapter","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:02:42Z","timestamp":1660788162000},"page":"205-237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Applications of Xylitol in Food, Material, Health, and Medical Sector"],"prefix":"10.1007","author":[{"given":"Priscila Vaz de","family":"Arruda","sequence":"first","affiliation":[]},{"given":"Thais Suzane","family":"Milessi","sequence":"additional","affiliation":[]},{"given":"J\u00fania","family":"Alves-Ferreira","sequence":"additional","affiliation":[]},{"given":"Luciane","family":"Sene","sequence":"additional","affiliation":[]},{"given":"Florbela","family":"Carvalheiro","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds C.","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Maria das Gra\u00e7as","family":"de Almeida Felipe","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"10_CR1","unstructured":"Ahuja K, Mamtani K (2020) Xylitol market size by application (chewing Gum, confectionary, food, personal care, pharmaceuticals, nutraceuticals), downstream application potential (xylaric acid, ethylene glycol, propylene glycol), industry analysis report, regional outlook, industry"},{"key":"10_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/foods9111592","volume":"9","author":"V Ahuja","year":"2020","unstructured":"Ahuja V, Macho M, Ewe D, Singh M, Saha S, Saurav K (2020) Biological and pharmacological potential of xylitol: a molecular insight of unique metabolism. Foods 9:1\u201324. https:\/\/doi.org\/10.3390\/foods9111592","journal-title":"Foods"},{"key":"10_CR3","doi-asserted-by":"publisher","unstructured":"Al-Teinaz YR (2020) Halal ingredients in food processing and food additives. Halal Food Handb 149\u2013167. https:\/\/doi.org\/10.1002\/9781118823026.ch10","DOI":"10.1002\/9781118823026.ch10"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1742-481X.2011.00781.x","volume":"8","author":"MCB Ammons","year":"2011","unstructured":"Ammons MCB, Ward LS, James GA (2011) Anti-biofilm efficacy of a lactoferrin\/xylitol wound hydrogel used in combination with silver wound dressings. Int Wound J 8:268\u2013273. https:\/\/doi.org\/10.1111\/j.1742-481X.2011.00781.x","journal-title":"Int Wound J"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.7845\/kjm.2020.0001","volume":"56","author":"H Anglenius","year":"2020","unstructured":"Anglenius H, Tiihonen K (2020) Evaluation of xylitol as an agent that controls the growth of skin microbes: Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes. Korean J Microbiol 56:54\u201358. https:\/\/doi.org\/10.7845\/kjm.2020.0001","journal-title":"Korean J Microbiol"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"14198","DOI":"10.1039\/c9ra00125e","volume":"9","author":"A Anjum","year":"2019","unstructured":"Anjum A, Chung PY, Ng SF (2019) PLGA\/xylitol nanoparticles enhance antibiofilm activity: via penetration into biofilm extracellular polymeric substances. RSC Adv 9:14198\u201314208. https:\/\/doi.org\/10.1039\/c9ra00125e","journal-title":"RSC Adv"},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu12072153","volume":"12","author":"V Argiana","year":"2020","unstructured":"Argiana V, Kanellos PT, Eleftheriadou I, Tsitsinakis G, Perrea D, Tentolouris NK (2020) Low-glycemic-index\/load desserts decrease glycemic and insulinemic response in patients with type 2 diabetes mellitus. Nutrients 12:1\u20139. https:\/\/doi.org\/10.3390\/nu12072153","journal-title":"Nutrients"},{"key":"10_CR8","doi-asserted-by":"publisher","unstructured":"Azarpazhooh A, Lawrence HP, Shah PS (2016) Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev 2016. https:\/\/doi.org\/10.1002\/14651858.CD007095.pub3","DOI":"10.1002\/14651858.CD007095.pub3"},{"key":"10_CR9","first-page":"43","volume":"17","author":"S Bawa","year":"2006","unstructured":"Bawa S (2006) The role of functional beverages with non-caloric and low-calorie sweeteners in the prevention of non-communicable (diet-related) diseases. Agro Food Ind Hi Tech 17:43\u201347","journal-title":"Agro Food Ind Hi Tech"},{"key":"10_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-812069-9.00019-4","volume-title":"Carbohydrate and noncarbohydrate sweeteners","author":"JN BeMiller","year":"2019","unstructured":"BeMiller JN (2019) Carbohydrate and noncarbohydrate sweeteners. Carbohydrate Chemistry for Food Scientists. Elsevier Inc., London, Third Edit. https:\/\/doi.org\/10.1016\/b978-0-12-812069-9.00019-4"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"7225","DOI":"10.1007\/s00253-020-10708-7\/Published","volume":"104","author":"AG Benahmed","year":"2020","unstructured":"Benahmed AG, Gasmi A, Arshad M, Shanaida M, Lysiuk R, Peana M, Pshyk-Titko I, Adamiv S, Shanaida Y, Bj\u00f8rklund G, Org B (2020) Health benefits of xylitol. Appl Microbiol Biotechnol 104:7225\u20137237. https:\/\/doi.org\/10.1007\/s00253-020-10708-7\/Published","journal-title":"Appl Microbiol Biotechnol"},{"key":"10_CR12","doi-asserted-by":"publisher","DOI":"10.1201\/9781439832523","volume-title":"Benders\u2019 dictionary of nutrition and food technology","author":"DA Bender","year":"2006","unstructured":"Bender DA (2006) Benders\u2019 dictionary of nutrition and food technology. Woodhead Publishing Limited, Eighth Edi"},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1039\/b922014c","volume":"12","author":"JJ Bozell","year":"2010","unstructured":"Bozell JJ, Petersen GR (2010) Technology development for the production of biobased products from biorefinery carbohydrates\u2014the US Department of Energy\u2019s \u201ctop 10\u201d revisited. Green Chem 12:539\u2013555. https:\/\/doi.org\/10.1039\/b922014c","journal-title":"Green Chem"},{"key":"10_CR14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/jbm.a.32733","volume":"95","author":"JP Bruggeman","year":"2010","unstructured":"Bruggeman JP, Bettinger CJ, Langer R (2010) Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility. J Biomed Mater Res Part A 95:92\u2013104. https:\/\/doi.org\/10.1002\/jbm.a.32733","journal-title":"J Biomed Mater Res Part A"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1002\/adma.200702377","volume":"20","author":"JP Bruggeman","year":"2008","unstructured":"Bruggeman JP, Bettinger CJ, Nijst CLE, Kohane DS, Langer R (2008) Biodegradable xylitol-based polymers. Adv Mater 20:1922\u20131927. https:\/\/doi.org\/10.1002\/adma.200702377","journal-title":"Adv Mater"},{"key":"10_CR16","doi-asserted-by":"publisher","unstructured":"Cagetti MG, Cocco F, Carta G, Maspero C, Campus G (2020) Long-term efficacy of magnolia bark extract and xylitol administered through chewing gums on caries in adults: a 2-year randomized controlled intervention trial. J Funct Foods 68. https:\/\/doi.org\/10.1016\/j.jff.2020.103891","DOI":"10.1016\/j.jff.2020.103891"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.foodhyd.2016.12.031","volume":"67","author":"L Cai","year":"2017","unstructured":"Cai L, Feng J, Regenstein J, Lv Y, Li J (2017) Confectionery gels: effects of low calorie sweeteners on the rheological properties and microstructure of fish gelatin. Food Hydrocoll 67:157\u2013165. https:\/\/doi.org\/10.1016\/j.foodhyd.2016.12.031","journal-title":"Food Hydrocoll"},{"key":"10_CR18","unstructured":"Calibre Research (2021) Global Xylitol Chewing Gum Market , Forecast to 2027"},{"key":"10_CR19","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.1039\/c2ra20113e","volume":"2","author":"Q Chen","year":"2012","unstructured":"Chen Q, Yang X, Li Y (2012) A comparative study on in vitro enzymatic degradation of poly(glycerol sebacate) and poly(xylitol sebacate). RSC Adv 2:4125\u20134134. https:\/\/doi.org\/10.1039\/c2ra20113e","journal-title":"RSC Adv"},{"key":"10_CR20","doi-asserted-by":"publisher","unstructured":"Chukwuma CI, Islam MS (2018) Xylitol: one name, numerous benefits. Phytochem 409\u2013435. https:\/\/doi.org\/10.1007\/978-3-319-27027-2_33","DOI":"10.1007\/978-3-319-27027-2_33"},{"key":"10_CR21","unstructured":"Ciprandi G, Mantia I La, Brunese FP, Varricchio Al, Varricchio At (2021) Hypertonic saline with xylitol and hyaluronate may shorten the viral shedding duration in asymptomatic COVID-19 positive subjects: a pilot study. J Biol Regul Homeost Agents 35:1151\u20131154"},{"key":"10_CR22","doi-asserted-by":"publisher","unstructured":"Cocate PG, Pereira LG, Marins JC, Cecon PR, Bressan J, Alfenas RC (2011) Metabolic responses to high glycemic index and low glycemic index meals: a controlled crossover clinical trial. Nutr J 10. https:\/\/doi.org\/10.1186\/1475-2891-10-1","DOI":"10.1186\/1475-2891-10-1"},{"key":"10_CR23","doi-asserted-by":"publisher","unstructured":"Cocco F, Cagetti MG, Majdub O, Campus G (2020) Concentration in saliva and antibacterial effect of xylitol chewing gum: in vivo and in vitro study. Appl Sci 10. https:\/\/doi.org\/10.3390\/APP10082900","DOI":"10.3390\/APP10082900"},{"key":"10_CR24","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1007\/s00784-017-2075-5","volume":"21","author":"F Cocco","year":"2017","unstructured":"Cocco F, Carta G, Cagetti MG, Strohmenger L, Lingstr\u00f6m P, Campus G (2017) The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults. Clin Oral Investig 21:2733\u20132740. https:\/\/doi.org\/10.1007\/s00784-017-2075-5","journal-title":"Clin Oral Investig"},{"key":"10_CR25","unstructured":"Commission Regulation (EU) 1129\/2011 of 11 November 2011 amending Annex II to Regulation (EC) No 1333\/2008 of the European Parliament and of the Council by establishing a Union list of food additives. Off J Eur Union 1\u2013177"},{"key":"10_CR26","unstructured":"Commission Regulation (EU) 2018\/1497 of 8 October 2018 amending Annex II to Regulation (EC) No 1333\/2008 of the European Parliament and of the Council as regards food category 17 and the use of food additives in food supplements. Off J Eur Union"},{"key":"10_CR27","unstructured":"Commission Regulation (EU) 257\/2010 setting up a programme for the re-evaluation of approved food additives in accordance with Regulation (EC) No 1333\/2008 of the European parliament and of the Council on food additivies. Off J Eur Union 19\u201327"},{"key":"10_CR28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.idairyj.2019.05.007","volume":"97","author":"GM Costa","year":"2019","unstructured":"Costa GM, Paula MM, Bar\u00e3o CE, Klososki SJ, Bonaf\u00e9 EG, Visentainer JV, Cruz AG, Pimentel TC (2019) Yoghurt added with Lactobacillus casei and sweetened with natural sweeteners and\/or prebiotics: implications on quality parameters and probiotic survival. Int Dairy J 97:139\u2013148. https:\/\/doi.org\/10.1016\/j.idairyj.2019.05.007","journal-title":"Int Dairy J"},{"key":"10_CR29","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0271-5317(86)80066-5","volume":"6","author":"SJ Culbert","year":"1986","unstructured":"Culbert SJ, Wang YM, Fritsche HA, Carr D, Lantin E, van Eys J (1986) Oral xylitol in American adults. Nutr Res 6:913\u2013922. https:\/\/doi.org\/10.1016\/S0271-5317(86)80066-5","journal-title":"Nutr Res"},{"key":"10_CR30","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1080\/21691401.2019.1573183","volume":"47","author":"Z Dai","year":"2019","unstructured":"Dai Z, Dang M, Zhang W, Murugan S, Teh SW, Pan H (2019) Biomimetic hydroxyapatite\/poly xylitol sebacic adibate\/vitamin K nanocomposite for enhancing bone regeneration. Artif Cells Nanomed Biotechnol 47:1898\u20131907. https:\/\/doi.org\/10.1080\/21691401.2019.1573183","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10_CR31","unstructured":"Danishyar A, Ashurst JV (2021) Acute otitis media. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470332\/. Accessed 3 June 2021"},{"key":"10_CR32","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1080\/09506608.2018.1505066","volume":"64","author":"Q Dasgupta","year":"2018","unstructured":"Dasgupta Q, Madras G, Chatterjee K (2018) Biodegradable polyol-based polymers for biomedical applications. Int Mater Rev 64:288\u2013309. https:\/\/doi.org\/10.1080\/09506608.2018.1505066","journal-title":"Int Mater Rev"},{"key":"10_CR33","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.ijpharm.2017.06.065","volume":"528","author":"Q Dasgupta","year":"2017","unstructured":"Dasgupta Q, Movva S, Chatterjee K, Madras G (2017) Controlled release from aspirin based linear biodegradable poly(anhydride esters) for anti-inflammatory activity. Int J Pharm 528:732\u2013740. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.06.065","journal-title":"Int J Pharm"},{"key":"10_CR34","unstructured":"DATAINTELO (2021) Xylitol chewing gum market 2020 | Global industry forecast to 2027. https:\/\/www.dataintelo.com\/report\/xylitol-chewing-gum-market\/. Accessed 5 Oct 2021"},{"key":"10_CR35","doi-asserted-by":"publisher","unstructured":"de Steenhuijsen Piters WAA, Sanders EAM, Bogaert D (2015) The role of the local microbial ecosystem in respiratory health and disease. Philos Trans R Soc B Biol Sci. https:\/\/doi.org\/10.1098\/rstb.2014.0294","DOI":"10.1098\/rstb.2014.0294"},{"key":"10_CR36","first-page":"105","volume":"32","author":"K Deepa","year":"2018","unstructured":"Deepa K, Jaisankar V (2018) Synthesis and characterisation of antihyperglycemic drug delivery applications of certain xylitol based copolyester. Trends Biomater Artif Organs 32:105\u2013110","journal-title":"Trends Biomater Artif Organs"},{"key":"10_CR37","doi-asserted-by":"publisher","first-page":"679","DOI":"10.5958\/0974-4150.2016.00094.8","volume":"9","author":"K Deepa","year":"2016","unstructured":"Deepa K, Jaisankar V (2016) Synthesis and characterisation of certain biodegradable xylitol based polyesters. Asian J Res Chem 9:679. https:\/\/doi.org\/10.5958\/0974-4150.2016.00094.8","journal-title":"Asian J Res Chem"},{"key":"10_CR38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.cattod.2018.07.060","volume":"344","author":"Y Delgado Arca\u00f1o","year":"2020","unstructured":"Delgado Arca\u00f1o Y, Valma\u00f1a Garc\u00eda OD, Mandelli D, Carvalho WA, Magalh\u00e3es Pontes LA (2020) Xylitol: a review on the progress and challenges of its production by chemical route. Catal Today 344:2\u201314. https:\/\/doi.org\/10.1016\/j.cattod.2018.07.060","journal-title":"Catal Today"},{"key":"10_CR39","doi-asserted-by":"publisher","unstructured":"Dhaliwal K, Dosanjh P (2018) Biodegradable polymers and their role in drug delivery systems. Biomed J Sci Tech Res 11:8315\u20138320. https:\/\/doi.org\/10.26717\/bjstr.2018.11.002056","DOI":"10.26717\/bjstr.2018.11.002056"},{"key":"10_CR40","first-page":"399","volume":"371","author":"I Dhooge","year":"2020","unstructured":"Dhooge I (2020) Acute otitis media in children. BMJ 371:399\u2013411","journal-title":"BMJ"},{"key":"10_CR41","doi-asserted-by":"publisher","unstructured":"Di Donato P, Poli A, Taurisano V, Nicolaus B (2014) Polysaccharides: applications in biology and biotechnology\/ polysaccharides from bioagro-waste new biomolecules-life. Polysaccharides 1\u201329. https:\/\/doi.org\/10.1007\/978-3-319-03751-6","DOI":"10.1007\/978-3-319-03751-6"},{"key":"10_CR42","unstructured":"EFSA\u2014Trusted science for safe food. https:\/\/www.efsa.europa.eu\/en. Accessed 19 Oct 2021"},{"key":"10_CR43","unstructured":"Experts Industries (2014) Xylitol\u2014a global market overview. https:\/\/www.marketresearch.com\/product\/sample-8164119.pdf. Accessed 20 Sept 2021"},{"key":"10_CR44","first-page":"142","volume":"40","author":"A Fawcett","year":"2010","unstructured":"Fawcett A, Phillips A, Malik R (2010) Hypoglycaemia and acute hepatic failure associated with accidental xylitol ingestion in a dog. Aust Vet Pract 40:142\u2013147","journal-title":"Aust Vet Pract"},{"key":"10_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-67261-6","volume":"10","author":"N Firoozi","year":"2020","unstructured":"Firoozi N, Kang Y (2020) Immobilization of FGF on poly(xylitol dodecanedioic acid) polymer for tissue regeneration. Sci Rep 10:1\u20138. https:\/\/doi.org\/10.1038\/s41598-020-67261-6","journal-title":"Sci Rep"},{"key":"10_CR46","unstructured":"Food Additive Status List\u2014FDA (2019). https:\/\/www.fda.gov\/food\/food-additives-petitions\/food-additive-status-list#ftnX. Accessed 19 Oct 2021"},{"key":"10_CR47","doi-asserted-by":"publisher","first-page":"197","DOI":"10.5530\/jyp.2020.12.60","volume":"12","author":"EG de Fraga","year":"2020","unstructured":"de Fraga EG, S., Campos, F.M.T., Cavalcante, M.P. da S., Martins, L.F.B., Neto, E.M.R., Mimica, M.J., (2020) Xylitol, a promising allied for oral heath. J Young Pharm 12:197\u2013200. https:\/\/doi.org\/10.5530\/jyp.2020.12.60","journal-title":"J Young Pharm"},{"key":"10_CR48","doi-asserted-by":"publisher","unstructured":"Ganie SA, Ali A, Mir TA, Li Q (2021) Physical and chemical modification of biopolymers and biocomposites. Adv Green Mater Fabr Charact Appl Biopolym Biocompos Woodhead Publ Mater 359\u2013377. https:\/\/doi.org\/10.1016\/B978-0-12-819988-6.00016-1","DOI":"10.1016\/B978-0-12-819988-6.00016-1"},{"key":"10_CR49","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1647\/2016-234","volume":"31","author":"BR Gardner","year":"2017","unstructured":"Gardner BR, Mitchell EP (2017) Acute, fatal, presumptive xylitol toxicosis in Cape sugarbirds (Promerops cafer). J Avian Med Surg 31:356\u2013358. https:\/\/doi.org\/10.1647\/2016-234","journal-title":"J Avian Med Surg"},{"key":"10_CR50","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.micpath.2018.06.038","volume":"123","author":"W Gargouri","year":"2018","unstructured":"Gargouri W, Zmantar T, Kammoun R, Kechaou N, Ghoul-Mazgar S (2018) Coupling xylitol with remineralizing agents improves tooth protection against demineralization but reduces antibiofilm effect. Microb Pathog 123:177\u2013182. https:\/\/doi.org\/10.1016\/j.micpath.2018.06.038","journal-title":"Microb Pathog"},{"key":"10_CR51","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.3390\/ijms15033640","volume":"15","author":"P Gentile","year":"2014","unstructured":"Gentile P, Chiono V, Carmagnola I, Hatton PV (2014) An overview of poly(lactic-co-glycolic) Acid (PLGA)-based biomaterials for bone tissue engineering. Int J Mol Sci 15:3640\u20133659. https:\/\/doi.org\/10.3390\/ijms15033640","journal-title":"Int J Mol Sci"},{"key":"10_CR52","doi-asserted-by":"publisher","unstructured":"Ghosh N, Das A, Sen CK (2019) Nutritional supplements and functional foods: Functional significance and global regulations. In: Bagchi D (ed) Nutraceutical and functional food regulations in the united states and around the world, 3rd edn. Academic Press, pp 13\u201335. https:\/\/doi.org\/10.1016\/B978-0-12-816467-9.00002-2","DOI":"10.1016\/B978-0-12-816467-9.00002-2"},{"key":"10_CR53","unstructured":"Grand View Research (2021) Xylitol market size worth $738.10 Million By 2028 | CAGR: 6.4% https:\/\/www.grandviewresearch.com\/press-release\/global-xylitol-market. Accessed 10 Dec 2021"},{"key":"10_CR54","unstructured":"GSFA (2021) Food additive details\u2014xylitol. https:\/\/www.fao.org\/gsfaonline\/additives\/details.html?id=146. Accessed 20 Oct 2021"},{"key":"10_CR55","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.foodhyd.2016.01.006","volume":"57","author":"Y Hao","year":"2016","unstructured":"Hao Y, Wang F, Huang W, Tang X, Zou Q, Li Z, Ogawa A (2016) Sucrose substitution by polyols in sponge cake and their effects on the foaming and thermal properties of egg protein. Food Hydrocoll 57:153\u2013159. https:\/\/doi.org\/10.1016\/j.foodhyd.2016.01.006","journal-title":"Food Hydrocoll"},{"key":"10_CR56","doi-asserted-by":"publisher","unstructured":"Harris R (2015) Phytotherapeutic uses of essential oils. In: Baer K, Buchbauer G (eds) Handbook of essential oils, science, technology, and applications, 2nd edn. Routledge, pp 381\u2013431. https:\/\/doi.org\/10.1201\/b19393-14","DOI":"10.1201\/b19393-14"},{"key":"10_CR57","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1155\/2012\/757838","volume":"2012","author":"MAF Hayashi","year":"2012","unstructured":"Hayashi MAF, Ducancel F, Konno K (2012) Natural peptides with potential applications in drug development, diagnosis, and\/or biotechnology. Int J Pept 2012:2012\u20132014. https:\/\/doi.org\/10.1155\/2012\/757838","journal-title":"Int J Pept"},{"key":"10_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2021.729988","volume":"9","author":"T He","year":"2021","unstructured":"He T, Xu C, Ding C, Liu X, Gu X (2021) Optimization of specific productivity for xylonic acid production by Gluconobacter oxydans using response surface methodology. Front Bioeng Biotechnol 9:1\u20139. https:\/\/doi.org\/10.3389\/fbioe.2021.729988","journal-title":"Front Bioeng Biotechnol"},{"key":"10_CR59","doi-asserted-by":"publisher","unstructured":"Hegde AM, Kavita R, Sushma KS, Shetty S (2012) Salivary sialic acid levels and dental health in children with congenital heart disease. J Clin Pediatr Dent 36:293\u2013296. https:\/\/doi.org\/10.17796\/jcpd.36.3.t585vt7v125630q4","DOI":"10.17796\/jcpd.36.3.t585vt7v125630q4"},{"key":"10_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.copbio.2015.09.001","volume":"37","author":"RW Hutkins","year":"2016","unstructured":"Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey G, Goh YJ, Hamaker B, Martens EC, Mills DA, Rastal RA, Vaughan E, Sanders ME (2016) Prebiotics: why definitions matter. Curr Opin Biotechnol 37:1\u20137. https:\/\/doi.org\/10.1016\/j.copbio.2015.09.001","journal-title":"Curr Opin Biotechnol"},{"key":"10_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2431-14-157","volume":"14","author":"P Intakorn","year":"2014","unstructured":"Intakorn P, Sonsuwan N, Noknu S, Moungthong G, Pir\u00e7on JY, Liu Y, Van Dyke MK, Hausdorff WP (2014) Haemophilus influenzae type b as an important cause of culture-positive acute otitis media in young children in Thailand: a tympanocentesis-based, multi-center, cross-sectional study. BMC Pediatr 14:1\u20139. https:\/\/doi.org\/10.1186\/1471-2431-14-157","journal-title":"BMC Pediatr"},{"key":"10_CR62","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1089\/jmf.2010.0015","volume":"14","author":"MS Islam","year":"2011","unstructured":"Islam MS (2011) Effects of xylitol as a sugar substitute on diabetes-related parameters in nondiabetic rats. J Med Food 14:505\u2013511. https:\/\/doi.org\/10.1089\/jmf.2010.0015","journal-title":"J Med Food"},{"key":"10_CR63","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1159\/000499194","volume":"53","author":"SJ Janket","year":"2019","unstructured":"Janket SJ, Benwait J, Isaac P, Ackerson LK, Meurman JH (2019) Oral and systemic effects of xylitol consumption. Caries Res 53:491\u2013501. https:\/\/doi.org\/10.1159\/000499194","journal-title":"Caries Res"},{"key":"10_CR64","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/jvp.12479","volume":"41","author":"K Jerzsele","year":"2018","unstructured":"Jerzsele K, Z., P\u00e1szti-Gere, E., Sterczer, Bers\u00e9nyi, A., Fodor, K., Szab\u00f3, D., Vajdovich, P., (2018) Effects of p.o. administered xylitol in cats. J Vet Pharmacol Ther 41:409\u2013414. https:\/\/doi.org\/10.1111\/jvp.12479","journal-title":"J Vet Pharmacol Ther"},{"key":"10_CR65","first-page":"1689","volume":"53","author":"Joint FAO\/WHO Codex Alimentarius Commission","year":"2014","unstructured":"Joint FAO\/WHO Codex Alimentarius Commission (2014) Codex Alimentarius\u202f: food additives. J Chem Inf Model 53:1689\u20131699","journal-title":"J Chem Inf Model"},{"key":"10_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/microorganisms9051083","volume":"9","author":"AN Khayyat","year":"2021","unstructured":"Khayyat AN, Hegazy WAH, Shaldam MA, Mosbah R, Almalki AJ, Ibrahim TS, Khayat MT, Khafagy ES, Soliman WE, Abbas HA (2021) Xylitol inhibits growth and blocks virulence in Serratia marcescens. Microorganisms 9:1\u201314. https:\/\/doi.org\/10.3390\/microorganisms9051083","journal-title":"Microorganisms"},{"key":"10_CR67","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/jfq.12083","volume":"37","author":"J-N Kim","year":"2014","unstructured":"Kim J-N, Park S, Shin W (2014) Textural and sensory characteristics of rice chiffon cake formulated with sugar alcohols instead of sucrose. J Food Qual 37:281\u2013290. https:\/\/doi.org\/10.1111\/jfq.12083","journal-title":"J Food Qual"},{"key":"10_CR68","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1079\/bjn20051431","volume":"93","author":"NA King","year":"2005","unstructured":"King NA, Craig SAS, Pepper T, Blundell JE (2005) Evaluation of the independent and combined effects of xylitol and polydextrose consumed as a snack on hunger and energy intake over 10 d. Br J Nutr 93:911\u2013915. https:\/\/doi.org\/10.1079\/bjn20051431","journal-title":"Br J Nutr"},{"key":"10_CR69","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1128\/AAC.39.8.1820","volume":"39","author":"T Kontiokari","year":"1995","unstructured":"Kontiokari T, Uhari M, Koskela M (1995) Effect of xylitol on growth of nasopharyngeal bacteria in vitro. Antimicrob Agents Chemother 39:1820\u20131823. https:\/\/doi.org\/10.1128\/AAC.39.8.1820","journal-title":"Antimicrob Agents Chemother"},{"key":"10_CR70","doi-asserted-by":"publisher","unstructured":"Kumar V, Nagar S, Sharma P (2020) Opportunity of plant oligosaccharides and polysaccharides in drug development, carbohydrates in drug discovery and development. Elsevier Inc. https:\/\/doi.org\/10.1016\/b978-0-12-816675-8.00015-4","DOI":"10.1016\/b978-0-12-816675-8.00015-4"},{"key":"10_CR71","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1507\/endocrj1954.18.309","volume":"18","author":"T Kuzuya","year":"1971","unstructured":"Kuzuya T, Kanazawa Y, Hayashi M, Kikuchi M, Ide T (1971) Species difference in plasma insulin responses to intravenous xylitol in man and several mammals. Endocrinol Jpn 18:309\u2013320","journal-title":"Endocrinol Jpn"},{"key":"10_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/polym12122969","volume":"12","author":"K Lang","year":"2020","unstructured":"Lang K, S\u00e1nchez-Leija RJ, Gross RA, Linhardt RJ (2020) Review on the impact of polyols on the properties of bio-based polyesters. Polymers (basel) 12:1\u201325. https:\/\/doi.org\/10.3390\/polym12122969","journal-title":"Polymers (basel)"},{"key":"10_CR73","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4014\/jmb.1606.06041","volume":"27","author":"CC Lee","year":"2017","unstructured":"Lee CC, Kibblewhite RE, Paavola CD, Orts WJ, Wagschal K (2017) Production of D-xylonic acid from hemicellulose using artificial enzyme complexes. J Microbiol Biotechnol 27:77\u201383. https:\/\/doi.org\/10.4014\/jmb.1606.06041","journal-title":"J Microbiol Biotechnol"},{"key":"10_CR74","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.biortech.2011.08.065","volume":"115","author":"H Liu","year":"2012","unstructured":"Liu H, Valdehuesa KNGN, Nisola GM, Ramos KRM, Chung WJ (2012) High yield production of d-xylonic acid from d-xylose using engineered Escherichia coli. Bioresour Technol Biocatal 115:244\u2013248. https:\/\/doi.org\/10.1016\/j.biortech.2011.08.065","journal-title":"Bioresour Technol Biocatal"},{"key":"10_CR75","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1079\/nrr200371","volume":"16","author":"G Livesey","year":"2003","unstructured":"Livesey G (2003) Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev 16:163\u2013191. https:\/\/doi.org\/10.1079\/nrr200371","journal-title":"Nutr Res Rev"},{"key":"10_CR76","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/pi.5301","volume":"66","author":"NI Liz-Andela","year":"2017","unstructured":"Liz-Andela NI, Benitez R, Martin-Franco J, Rojas G (2017) Tunable polyesterification of xylitol: from linear to crosslinked structures. Polym Int 66:532\u2013539. https:\/\/doi.org\/10.1002\/pi.5301","journal-title":"Polym Int"},{"key":"10_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2019.00037","volume":"7","author":"IJ Macha","year":"2019","unstructured":"Macha IJ, Ben-Nissan B, Vilchevskaya EN, Morozova AS, Abali BE, M\u00fcller WH, Rickert W (2019) Drug delivery from polymer-based nanopharmaceuticals-an experimental study complemented by simulations of selected diffusion processes. Front Bioeng Biotechnol 7:1\u201314. https:\/\/doi.org\/10.3389\/fbioe.2019.00037","journal-title":"Front Bioeng Biotechnol"},{"key":"10_CR78","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1750-3841.2007.00350.x","volume":"72","author":"HS M\u00e4kel\u00e4inen","year":"2007","unstructured":"M\u00e4kel\u00e4inen HS, M\u00e4kivuokko HA, Salminen SJ, Rautonen NE, Ouwehand AC (2007) The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator. J Food Sci 72:153\u2013159. https:\/\/doi.org\/10.1111\/j.1750-3841.2007.00350.x","journal-title":"J Food Sci"},{"key":"10_CR79","doi-asserted-by":"publisher","unstructured":"M\u00e4kinen KK (2016) Gastrointestinal disturbances associated with the consumption of sugar alcohols with special consideration of xylitol: scientific review and instructions for dentists and other health-care professionals. Int J Dent 2016. https:\/\/doi.org\/10.1155\/2016\/5967907","DOI":"10.1155\/2016\/5967907"},{"key":"10_CR80","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1177\/00220345000790060101","volume":"79","author":"KK M\u00e4kinen","year":"2000","unstructured":"M\u00e4kinen KK (2000) The rocky road of xylitol to its clinical application. J Dent Res 79:1352\u20131355. https:\/\/doi.org\/10.1177\/00220345000790060101","journal-title":"J Dent Res"},{"key":"10_CR81","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/idj.12038","volume":"63","author":"KK M\u00e4kinen","year":"2013","unstructured":"M\u00e4kinen KK, J\u00e4rvinen KL, Anttila CH, Luntamo LM, Vahlberg T (2013) Topical xylitol administration by parents for the promotion of oral health in infants: a caries prevention experiment at a finnish public health centre. Int Dent J 63:210\u2013224. https:\/\/doi.org\/10.1111\/idj.12038","journal-title":"Int Dent J"},{"key":"10_CR82","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jdermsci.2005.01.006","volume":"38","author":"K Masako","year":"2005","unstructured":"Masako K, Hideyuki I, Shigeyuki O, Zenro I (2005a) A novel method to control the balance of skin microflora: Part 1. attack on biofilm of Staphylococcus aureus without antibiotics. J Dermatol Sci 38:197\u2013205. https:\/\/doi.org\/10.1016\/j.jdermsci.2005.01.006","journal-title":"J Dermatol Sci"},{"key":"10_CR83","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jdermsci.2005.01.003","volume":"38","author":"K Masako","year":"2005","unstructured":"Masako K, Yusuke K, Hideyuki I, Atsuko M, Yoshiki M, Kayoko M, Makoto K (2005b) A novel method to control the balance of skin microflora: part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. J Dermatol Sci 38:207\u2013213. https:\/\/doi.org\/10.1016\/j.jdermsci.2005.01.003","journal-title":"J Dermatol Sci"},{"key":"10_CR84","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S0026-0495(98)90243-8","volume":"47","author":"PT Mattila","year":"1998","unstructured":"Mattila PT, Knuuttila MLE, Svanberg MJ (1998a) Dietary xylitol supplementation prevents osteoporotic changes in streptozotocin-diabetic rats. Metabolism 47:578\u2013583. https:\/\/doi.org\/10.1016\/S0026-0495(98)90243-8","journal-title":"Metabolism"},{"key":"10_CR85","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-1-4612-2228-6_16","volume-title":"Nutritional aspects of osteoporosis","author":"PT Mattila","year":"1998","unstructured":"Mattila PT, Svanberg MJ, Knuuttila MLE (1998b) Dietary xylitol protects against osseal changes experimental osteoporosis. In: Burckhardt P, Dawson-Hughes B, Heaney RP (eds) Nutritional aspects of osteoporosis. Springer-Verlag, New York, pp 157\u2013162"},{"key":"10_CR86","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1093\/jn\/126.7.1865","volume":"126","author":"PT Mattila","year":"1996","unstructured":"Mattila PT, Svanberg MJ, M\u00e4kinen KK, Knuuttila MLE (1996) Dietary xylitol, sorbitol and D-mannitol but not erythritol retard bone resorption in rats. J Nutr 126:1865\u20131870. https:\/\/doi.org\/10.1093\/jn\/126.7.1865","journal-title":"J Nutr"},{"key":"10_CR87","doi-asserted-by":"crossref","unstructured":"Miake Y, Saeki Y, Takahashi M, Yanagisawa T (2003) Remineralization effects of xylitol on demineralized enamel. J Electron Microsc","DOI":"10.1093\/jmicro\/52.5.471"},{"key":"10_CR88","doi-asserted-by":"publisher","DOI":"10.1002\/9780470996003","author":"H Mitchell","year":"2007","unstructured":"Mitchell H (2007) Sweeteners and sugar alternatives in food technology. Blackwell Publishing Ltd. https:\/\/doi.org\/10.1002\/9780470996003","journal-title":"Blackwell Publishing Ltd"},{"key":"10_CR89","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.fbio.2018.10.008","volume":"26","author":"D Mohanty","year":"2018","unstructured":"Mohanty D, Misra S, Mohapatra S, Sahu PS (2018) Prebiotics and synbiotics: recent concepts in nutrition. Food Biosci 26:152\u2013160. https:\/\/doi.org\/10.1016\/j.fbio.2018.10.008","journal-title":"Food Biosci"},{"key":"10_CR90","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41579-019-0313-3","volume":"18","author":"MF Moradali","year":"2020","unstructured":"Moradali MF, Rehm BHA (2020) Bacterial biopolymers: from pathogenesis to advanced materials. Nat Rev Microbiol 18:195\u2013210. https:\/\/doi.org\/10.1038\/s41579-019-0313-3","journal-title":"Nat Rev Microbiol"},{"key":"10_CR91","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00444","author":"E Moriconi","year":"2020","unstructured":"Moriconi E, Feraco A, Marzolla V, Infante M, Lombardo M, Fabbri A, Caprio M (2020) Neuroendocrine and metabolic effects of low-calorie and non-calorie sweeteners. Front Endocrinol (lausanne). https:\/\/doi.org\/10.3389\/fendo.2020.00444","journal-title":"Front Endocrinol (lausanne)"},{"key":"10_CR92","doi-asserted-by":"publisher","first-page":"13987","DOI":"10.1021\/acsomega.0c05875","volume":"6","author":"M Mosquera","year":"2021","unstructured":"Mosquera M, Orozco F, Ben\u00edtez R, Martin J, Rojas G (2021) Controlled branching by step-growth polymerization of xylitol and succinic acid via microwave irradiation. ACS Omega 6:13987\u201313994. https:\/\/doi.org\/10.1021\/acsomega.0c05875","journal-title":"ACS Omega"},{"key":"10_CR93","doi-asserted-by":"publisher","unstructured":"Mussatto SI (2012) Application of xylitol in food formulations and benefits for health. In: Da Silva SS, Chandel AK (eds), D-Xylitol: fermentative production, application and commercialization. Springer, Berlin, pp 309\u2013323. https:\/\/doi.org\/10.1007\/978-3-642-31887-0_14","DOI":"10.1007\/978-3-642-31887-0_14"},{"key":"10_CR94","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.bcmd.2008.12.005","volume":"42","author":"ET Nkhoma","year":"2009","unstructured":"Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E (2009) The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells. Mol Dis 42:267\u2013278. https:\/\/doi.org\/10.1016\/j.bcmd.2008.12.005","journal-title":"Mol Dis"},{"key":"10_CR95","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.tifs.2020.03.004","volume":"99","author":"A Nyyss\u00f6l\u00e4","year":"2020","unstructured":"Nyyss\u00f6l\u00e4 A, Ellil\u00e4 S, Nordlund E, Poutanen K (2020) Reduction of FODMAP content by bioprocessing. Trends Food Sci Technol 99:257\u2013272. https:\/\/doi.org\/10.1016\/j.tifs.2020.03.004","journal-title":"Trends Food Sci Technol"},{"key":"10_CR96","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.apcata.2013.02.023","volume":"456","author":"JU Oltmanns","year":"2013","unstructured":"Oltmanns JU, Palkovits S, Palkovits R (2013) Kinetic investigation of sorbitol and xylitol dehydration catalyzed by silicotungstic acid in water. Appl Catal A Gen 456:168\u2013173. https:\/\/doi.org\/10.1016\/j.apcata.2013.02.023","journal-title":"Appl Catal A Gen"},{"key":"10_CR97","doi-asserted-by":"publisher","unstructured":"Piatek-Hnat M, Bomba K, P\u0119ksi\u0144ski J (2020) Structure and properties of biodegradable poly (xylitol sebacate-co-butylene sebacate) copolyester. Molecules 25. https:\/\/doi.org\/10.3390\/molecules25071541","DOI":"10.3390\/molecules25071541"},{"key":"10_CR98","first-page":"8","volume":"3","author":"RS Prakasham","year":"2009","unstructured":"Prakasham RS, Rao RS, Hobbs PJ (2009) Current trends in biotechnological production of xylitol and future prospects. Curr Trends Biotechnol Pharm 3:8\u201336","journal-title":"Curr Trends Biotechnol Pharm"},{"key":"10_CR99","doi-asserted-by":"publisher","unstructured":"Qusa MH, Siddique AB, Nazzal S, El Sayed KA (2019) Novel olive oil phenolic (\u2212)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities. Int J Pharm 569. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118596","DOI":"10.1016\/j.ijpharm.2019.118596"},{"key":"10_CR100","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.anaerobe.2017.03.019","volume":"47","author":"M R\u00e4tsep","year":"2017","unstructured":"R\u00e4tsep M, K\u00f5ljalg S, Sepp E, Smidt I, Truusalu K, Songisepp E, Stsepetova J, Naaber P, Mikelsaar RH, Mikelsaar M (2017) A combination of the probiotic and prebiotic product can prevent the germination of Clostridium difficile spores and infection. Anaerobe 47:94\u2013103. https:\/\/doi.org\/10.1016\/j.anaerobe.2017.03.019","journal-title":"Anaerobe"},{"key":"10_CR101","doi-asserted-by":"publisher","unstructured":"Regulation (EU) 1169, 2011 of The European Parliament and of The Council of 25, (October 2011) on the provision of food information to consumers, amending Regulations (EC) No 1924\/2006 and (EC) No 1925\/2006 of the European Parliament and of the Council, an. Off J Eur Union 18\u201363. https:\/\/doi.org\/10.1075\/ttwia.27.04ker","DOI":"10.1075\/ttwia.27.04ker"},{"key":"10_CR102","unstructured":"Research and Markets (2018) Xylitol in personal care and cosmetics market size, share & trends analysis report by application (skin, hair, oral), by Region (Asia Pacific, North America), and segment forecasts, 2018\u20132025. https:\/\/www.grandviewresearch.com\/industry-analysis\/xylitol-in-personal-care-cosmetics-market. Accessed 15 Sept 2021"},{"key":"10_CR103","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1080\/10408398.2019.1625859","volume":"60","author":"T Rice","year":"2020","unstructured":"Rice T, Zannini E, Arendt K, E., Coffey, A., (2020) A review of polyols\u2013biotechnological production, food applications, regulation, labeling and health effects. Crit Rev Food Sci Nutr 60:2034\u20132051. https:\/\/doi.org\/10.1080\/10408398.2019.1625859","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10_CR104","doi-asserted-by":"publisher","unstructured":"Riley P, Moore D, Ahmed F, Sharif MO, Worthington HV (2015) Xylitol-containing products for preventing dental caries in children and adults. Cochrane Database Syst Rev 37\u201338. https:\/\/doi.org\/10.1002\/14651858.CD010743.pub2","DOI":"10.1002\/14651858.CD010743.pub2"},{"key":"10_CR105","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.bbapap.2018.07.003","volume":"1866","author":"S Roy","year":"2018","unstructured":"Roy S, Bhat R (2018) Effect of polyols on the structure and aggregation of recombinant human \u03b3-Synuclein, an intrinsically disordered protein. Biochim Biophys Acta Proteins Proteomics 1866:1029\u20131042. https:\/\/doi.org\/10.1016\/j.bbapap.2018.07.003","journal-title":"Biochim Biophys Acta Proteins Proteomics"},{"key":"10_CR106","doi-asserted-by":"publisher","unstructured":"Sable R, Parajuli P, Jois S (2017) Peptides, peptidomimetics, and polypeptides from marine sources: a wealth of natural sources for pharmaceutical applications. Mar Drugs 15. https:\/\/doi.org\/10.3390\/md15040124","DOI":"10.3390\/md15040124"},{"key":"10_CR107","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1002\/cssc.201800494","volume":"11","author":"S Sadula","year":"2018","unstructured":"Sadula S, Saha B (2018) Aerobic oxidation of xylose to xylaric acid in water over pt catalysts. Chemsuschem 11:2124\u20132129. https:\/\/doi.org\/10.1002\/cssc.201800494","journal-title":"Chemsuschem"},{"key":"10_CR108","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1016\/j.healun.2003.09.023","volume":"23","author":"U Sajjan","year":"2004","unstructured":"Sajjan U, Moreira J, Liu M, Humar A, Chaparro C, Forstner J, Keshavjee S (2004) A novel model to study bacterial adherence to the transplanted airway: inhibition of Burkholderia cepacia adherence to human airway by dextran and xylitol. J Hear Lung Transplant 23:1382\u20131391. https:\/\/doi.org\/10.1016\/j.healun.2003.09.023","journal-title":"J Hear Lung Transplant"},{"key":"10_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081813","author":"K Salli","year":"2019","unstructured":"Salli K, Lehtinen MJ, Tiihonen K, Ouwehand AC (2019) Xylitol\u2019s health benefits beyond dental health: a comprehensive review. Nutrients. https:\/\/doi.org\/10.3390\/nu11081813","journal-title":"Nutrients"},{"key":"10_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2019.103234","volume":"82","author":"M de Samaniego-Vaesken","year":"2019","unstructured":"de Samaniego-Vaesken M, L., Partearroyo, T., Cano, A., Urrialde, R., Varela-Moreiras, G., (2019) Novel database of declared low- and no-calorie sweeteners from foods and beverages available in Spain. J Food Compos Anal 82:103234. https:\/\/doi.org\/10.1016\/j.jfca.2019.103234","journal-title":"J Food Compos Anal"},{"key":"10_CR111","doi-asserted-by":"publisher","unstructured":"Sani NFM, Jafri NA, Majid NA, Rosaidi NA, Onn M (2021) Effect of glutamic acid as additional monomer in biodegradable poly(xylitol sebacate glutamate) polymer. Egypt J Chem 64:2783\u20132787. https:\/\/doi.org\/10.21608\/ejchem.2021.54273.3128","DOI":"10.21608\/ejchem.2021.54273.3128"},{"key":"10_CR112","doi-asserted-by":"publisher","unstructured":"Sani NFM, Wahit MU, Tham WH, Majid NAA (2018) Biodegradable poly(xylitol sebacate dodecanoate)\/nano-hydroxyapatite composite for potential used in biomedical applications. AIP Conf Proc 1985. https:\/\/doi.org\/10.1063\/1.5047157","DOI":"10.1063\/1.5047157"},{"key":"10_CR113","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s10266-010-0143-2","volume":"99","author":"H Sato","year":"2011","unstructured":"Sato H, Ide Y, Nasu M, Numabe Y (2011) The effects of oral xylitol administration on bone density in rat femur. Odontology 99:28\u201333. https:\/\/doi.org\/10.1007\/s10266-010-0143-2","journal-title":"Odontology"},{"key":"10_CR114","doi-asserted-by":"publisher","unstructured":"Sato T, Kusuhara S, Yokoi W, Ito M, Miyazaki K (2016) Prebiotic potential of L-sorbose and xylitol in promoting the growth and metabolic activity of specific butyrate-producing bacteria in human fecal culture. FEMS Microbiol Ecol 93:5\u201311. https:\/\/doi.org\/10.1093\/femsec\/fiw227","DOI":"10.1093\/femsec\/fiw227"},{"key":"10_CR115","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/00075197-200409000-00009","volume":"7","author":"W Scheppach","year":"2004","unstructured":"Scheppach W, Weiler F (2004) The butyrate story: old wine in new bottles? Curr Opin Clin Nutr Metab Care 7:563\u2013567. https:\/\/doi.org\/10.1097\/00075197-200409000-00009","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10_CR116","doi-asserted-by":"publisher","unstructured":"Shariatinia Z (2019) Pharmaceutical applications of natural polysaccharides. In: Hasnain MS, Nayak AK (eds) Natural polysaccharides drug delivery and biomedical applications. Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-817055-7.00002-9","DOI":"10.1016\/B978-0-12-817055-7.00002-9"},{"key":"10_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2021.110469","volume":"152","author":"A Sotoudeh","year":"2021","unstructured":"Sotoudeh A, Darbemamieh G, Goodarzi V, Shojaei S, Asefnejad A (2021) Tissue engineering needs new biomaterials: poly(xylitol-dodecanedioic acid)\u2013co-polylactic acid (PXDDA-co-PLA) and its nanocomposites. Eur Polym J 152:110469. https:\/\/doi.org\/10.1016\/j.eurpolymj.2021.110469","journal-title":"Eur Polym J"},{"key":"10_CR118","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2217\/fmb-2020-0286","volume":"16","author":"C Stathis","year":"2021","unstructured":"Stathis C, Victoria N, Loomis K, Nguyen SA, Eggers M, Septimus E, Safdar N (2021) Review of the use of nasal and oral antiseptics during a global pandemic. Fut Microbiol 16:119\u2013130. https:\/\/doi.org\/10.2217\/fmb-2020-0286","journal-title":"Fut Microbiol"},{"key":"10_CR119","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cattod.2013.12.040","volume":"234","author":"J Sun","year":"2014","unstructured":"Sun J, Liu H (2014) Selective hydrogenolysis of biomass-derived xylitol to ethylene glycol and propylene glycol on Ni\/C and basic oxide-promoted Ni\/C catalysts. Catal Today 234:75\u201382. https:\/\/doi.org\/10.1016\/j.cattod.2013.12.040","journal-title":"Catal Today"},{"key":"10_CR120","doi-asserted-by":"publisher","first-page":"125","DOI":"10.5005\/JP-JOURNALS-10024-2225","volume":"19","author":"Z Talattof","year":"2018","unstructured":"Talattof Z, Azad A, Zahed M, Shahradnia N (2018) Antifungal activity of Xylitol against Candida albicans: an in vitro study. J Contemp Dent Pract 19:125\u2013129. https:\/\/doi.org\/10.5005\/JP-JOURNALS-10024-2225","journal-title":"J Contemp Dent Pract"},{"key":"10_CR121","doi-asserted-by":"publisher","first-page":"23993","DOI":"10.3390\/ijms141223993","volume":"14","author":"M Tamura","year":"2013","unstructured":"Tamura M, Hoshi C, Hori S (2013) Xylitol affects the intestinal microbiota and metabolism of daidzein in adult Male mice. Int J Mol Sci 14:23993\u201324007. https:\/\/doi.org\/10.3390\/ijms141223993","journal-title":"Int J Mol Sci"},{"key":"10_CR122","unstructured":"The Manomet Current (2021) https:\/\/www.manometcurrent.com\/pharma-grade-xylitol-market-to-experience-astonishing-growth-players-danisco-roquette-futaste-huakang-shandong-longlive-bio-technology-yuxin-xylitol-technology\/. Accessed 2 Sept 2021"},{"key":"10_CR123","doi-asserted-by":"publisher","unstructured":"Tiefenbacher KF (2017) Technology of main ingredients\u2014sweeteners and lipids. In: Tiefenbacher KF (ed) The technology of wafers and waffles I: operational aspects. Academic Press, pp 123\u2014225. https:\/\/doi.org\/10.1016\/b978-0-12-809438-9.00003-x","DOI":"10.1016\/b978-0-12-809438-9.00003-x"},{"key":"10_CR124","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109085","volume":"324","author":"N Tomonobu","year":"2020","unstructured":"Tomonobu N, Komalasari NLGY, Sumardika IW, Jiang F, Chen Y, Yamamoto K, ichi, Kinoshita, R., Murata, H., Inoue, Y., Sakaguchi, M., (2020) Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level. Chem Biol Interact 324:109085. https:\/\/doi.org\/10.1016\/j.cbi.2020.109085","journal-title":"Chem Biol Interact"},{"key":"10_CR125","doi-asserted-by":"publisher","unstructured":"Uebanso T, Kano S, Yoshimoto A, Naito C, Shimohata T, Mawatari K, Takahashi A (2017) Effects of consuming xylitol on gut microbiota and lipid metabolism in mice. Nutrients 9. https:\/\/doi.org\/10.3390\/nu9070756","DOI":"10.3390\/nu9070756"},{"key":"10_CR126","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0264-410X(00)00294-2","volume":"19","author":"M Uhari","year":"2000","unstructured":"Uhari M, Tapiainen T, Kontiokari T (2000) Xylitol in preventing acute otitis media. Vaccine 19:144\u2013147. https:\/\/doi.org\/10.1016\/S0264-410X(00)00294-2","journal-title":"Vaccine"},{"key":"10_CR127","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1080\/10408398.2012.702288","volume":"55","author":"S Ur-Rehman","year":"2015","unstructured":"Ur-Rehman S, Mushtaq Z, Zahoor T, Jamil A, Murtaza MA (2015) Xylitol: a review on bioproduction, application, health benefits, and related safety issues. Crit Rev Food Sci Nutr 55:1514\u20131528. https:\/\/doi.org\/10.1080\/10408398.2012.702288","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10_CR128","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1128\/iai.61.2.619-626.1993","volume":"61","author":"SL Vargas","year":"1993","unstructured":"Vargas SL, Patrick CC, Ayers GD, Hughes WT (1993) Modulating effect of dietary carbohydrate supplementation on Candida albicans colonization and invasion in a neutropenic mouse model. Infect Immun 61:619\u2013626. https:\/\/doi.org\/10.1128\/iai.61.2.619-626.1993","journal-title":"Infect Immun"},{"key":"10_CR129","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/s41551-021-00698-w","volume":"5","author":"AM Vargason","year":"2021","unstructured":"Vargason AM, Anselmo AC, Mitragotri S (2021) The evolution of commercial drug delivery technologies. Nat Biomed Eng 5:951\u2013967. https:\/\/doi.org\/10.1038\/s41551-021-00698-w","journal-title":"Nat Biomed Eng"},{"key":"10_CR130","first-page":"63","volume":"35","author":"A Varricchio","year":"2021","unstructured":"Varricchio A, Mantia., I. La, Brunese, F., Ciprandi, G., (2021) Smell recovery in patients with COVID-19: an experience with nebulized nasal treatment. J Biol Regul Homeost Agents 35:63\u201366","journal-title":"J Biol Regul Homeost Agents"},{"key":"10_CR131","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1542\/peds.2013-2373","volume":"133","author":"L Vernacchio","year":"2014","unstructured":"Vernacchio L, Corwin MJ, Vezina RM, Pelton SI, Feldman HA, Coyne-Beasley T, Mitchell AA (2014) Xylitol syrup for the prevention of acute otitis media. Pediatrics 133:289\u2013295. https:\/\/doi.org\/10.1542\/peds.2013-2373","journal-title":"Pediatrics"},{"key":"10_CR132","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1039\/c3py01213a","volume":"5","author":"C Vilela","year":"2014","unstructured":"Vilela C, Sousa AF, Fonseca AC, Serra AC, Coelho JFJ, Freire CSR, Silvestre AJD (2014) The quest for sustainable polyesters-insights into the future. Polym Chem 5:3119\u20133141. https:\/\/doi.org\/10.1039\/c3py01213a","journal-title":"Polym Chem"},{"key":"10_CR133","doi-asserted-by":"crossref","unstructured":"Werpy T, Petersen G, Aden A, Bozell J, Holladay J, White J, Manheim A, Elliot D, Lasure L, Jones S, Gerber M, Ibsen K, Lumberg L, Kelley S (2004) Top value added chemicals from biomass. Volume I\u2014Results of screening for potential candidates from sugars and synthesis gas. U.S. Department of Energy (DOE), Oak Ridge, TN","DOI":"10.2172\/15008859"},{"key":"10_CR134","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1152\/ajpendo.00037.2016.-With","volume":"310","author":"BK W\u00f6lnerhanssen","year":"2016","unstructured":"W\u00f6lnerhanssen BK, Cajacob L, Keller N, Doody A, Rehfeld JF, Drewe J, Peterli R, Beglinger C, Meyer-Gerspach AC (2016) Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Endocrinol Metab 310:1053\u20131061. https:\/\/doi.org\/10.1152\/ajpendo.00037.2016.-With","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10_CR135","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1623757","author":"BK W\u00f6lnerhanssen","year":"2019","unstructured":"W\u00f6lnerhanssen BK, Meyer-Gerspach AC, Beglinger C, Islam MS (2019) Metabolic effects of the natural sweeteners xylitol and erythritol: a comprehensive review. Crit Rev Food Sci Nutr. https:\/\/doi.org\/10.1080\/10408398.2019.1623757","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10_CR136","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1039\/c6cp06831f","volume":"19","author":"A Yamaguchi","year":"2017","unstructured":"Yamaguchi A, Muramatsu N, Mimura N, Shirai M, Sato O (2017) Intramolecular dehydration of biomass-derived sugar alcohols in high-temperature water. Phys Chem Chem Phys 19:2714\u20132722. https:\/\/doi.org\/10.1039\/c6cp06831f","journal-title":"Phys Chem Chem Phys"},{"key":"10_CR137","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3892\/ijo.2013.1917","volume":"43","author":"EY Yi","year":"2013","unstructured":"Yi EY, Kim YJ (2013) Xylitol inhibits in vitro and in vivo angiogenesis by suppressing the NF-\u03baB and Akt signaling pathways. Int J Oncol 43:315\u2013320. https:\/\/doi.org\/10.3892\/ijo.2013.1917","journal-title":"Int J Oncol"},{"key":"10_CR138","doi-asserted-by":"publisher","unstructured":"Yin SY, Kim HJ, Kim HJ (2014) Protective effect of dietary xylitol on Influenza a virus infection. PLoS ONE 9. https:\/\/doi.org\/10.1371\/journal.pone.0084633","DOI":"10.1371\/journal.pone.0084633"},{"key":"10_CR139","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0065-2628(08)60237-2","volume":"25","author":"R Ylikahri","year":"1979","unstructured":"Ylikahri R (1979) Metabolic and nutritional aspects of xylitol. Adv Food Res 25:159\u2013180. https:\/\/doi.org\/10.1016\/S0065-2628(08)60237-2","journal-title":"Adv Food Res"},{"key":"10_CR140","doi-asserted-by":"publisher","first-page":"11614","DOI":"10.1073\/pnas.97.21.11614","volume":"97","author":"J Zabner","year":"2000","unstructured":"Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, Smith JJ, Welsh MJ (2000) The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proc Natl Acad Sci 97:11614\u201311619","journal-title":"Proc Natl Acad Sci"},{"key":"10_CR141","doi-asserted-by":"publisher","first-page":"66965","DOI":"10.1039\/c5ra11902b","volume":"5","author":"M Zhang","year":"2015","unstructured":"Zhang M, Wu Y, Zhao X, Gao K, Ma PX, Guo B (2015) Biocompatible degradable injectable hydrogels from methacrylated poly(ethylene glycol)-co-poly(xylitol sebacate) and cyclodextrins for release of hydrophilic and hydrophobic drugs. RSC Adv 5:66965\u201366974. https:\/\/doi.org\/10.1039\/c5ra11902b","journal-title":"RSC Adv"},{"key":"10_CR142","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2021.101430","volume":"120","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Song M, Xu Y, Wang W, Wang Z, Zhang L (2021) Bio-based polyesters: recent progress and future prospects. Prog Polym Sci 120:101430. https:\/\/doi.org\/10.1016\/j.progpolymsci.2021.101430","journal-title":"Prog Polym Sci"}],"container-title":["Current Advances in Biotechnological Production of Xylitol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-04942-2_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:05:26Z","timestamp":1660788326000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-04942-2_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031049415","9783031049422"],"references-count":142,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-04942-2_10","relation":{},"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"19 August 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}