{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T14:50:15Z","timestamp":1742914215049,"version":"3.40.3"},"publisher-location":"Cham","reference-count":201,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783031185861"},{"type":"electronic","value":"9783031185878"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-3-031-18587-8_25","type":"book-chapter","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T19:57:11Z","timestamp":1677009431000},"page":"779-822","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Trends from Plant Secondary Metabolism in the Pharmaceutical Industry"],"prefix":"10.1007","author":[{"given":"H.","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"R.","family":"P\u00e9rez-Gregorio","sequence":"additional","affiliation":[]},{"given":"I.","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"S.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"V.","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"R.","family":"Dias","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"25_CR1","first-page":"204","volume":"92","author":"MA Abdalla","year":"2019","unstructured":"Abdalla MA, M\u00fchling KH (2019) Plant-derived sulfur containing natural products produced as a response to biotic and abiotic stresses: a review of their structural diversity and medicinal importance. J Appl Bot Food Qual 92:204\u2013215","journal-title":"J Appl Bot Food Qual"},{"issue":"2","key":"25_CR2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s11101-020-09691-8","volume":"20","author":"S Ahmed","year":"2021","unstructured":"Ahmed S, Kovinich N (2021) Regulation of phytoalexin biosynthesis for agriculture and human health. Phytochem Rev 20(2):483\u2013505","journal-title":"Phytochem Rev"},{"key":"25_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.gene.2014.08.013","volume":"550","author":"NU Ahmed","year":"2014","unstructured":"Ahmed NU et al (2014) Characterization of dihydroflavonol 4-reductase (DFR) genes and their association with cold and freezing stress in Brassica rapa. Gene 550:46\u201355","journal-title":"Gene"},{"issue":"6","key":"25_CR4","doi-asserted-by":"publisher","first-page":"G1131","DOI":"10.1152\/ajpgi.00562.2005","volume":"290","author":"C Anthoni","year":"2006","unstructured":"Anthoni C et al (2006) Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis. Am J Physiol Gastrointest Liver Physiol 290(6):G1131\u2013G1137","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"25_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/215872","volume":"2014","author":"S Appalasamy","year":"2014","unstructured":"Appalasamy S et al (2014) Antimicrobial activity of artemisinin and precursor derived from in vitro plantlets of Artemisia annua L. Biomed Res Int 2014:215872","journal-title":"Biomed Res Int"},{"key":"25_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127535","volume":"338","author":"FF Ara\u00fajo","year":"2021","unstructured":"Ara\u00fajo FF et al (2021) Polyphenols and their applications: an approach in food chemistry and innovation potential. Food Chem 338:127535","journal-title":"Food Chem"},{"key":"25_CR7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ymben.2017.02.007","volume":"40","author":"P Arendt","year":"2017","unstructured":"Arendt P et al (2017) An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids. Metab Eng 40:165\u2013175","journal-title":"Metab Eng"},{"key":"25_CR8","doi-asserted-by":"publisher","unstructured":"Ashour M, Wink M, Gershenzon J (2018) Biochemistry of terpenoids: monoterpenes, sesquiterpenes and diterpenes. Annu Plant Rev 258\u2013303. https:\/\/doi.org\/10.1002\/9781119312994.apr0427","DOI":"10.1002\/9781119312994.apr0427"},{"key":"25_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.physbeh.2014.06.003","volume":"135","author":"A Bahi","year":"2014","unstructured":"Bahi A et al (2014) \u03b2-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiol Behav 135:119\u2013124","journal-title":"Physiol Behav"},{"issue":"2","key":"25_CR10","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","volume":"46","author":"F Bakkali","year":"2008","unstructured":"Bakkali F et al (2008) Biological effects of essential oils\u2014a review. Food Chem Toxicol 46(2):446\u2013475","journal-title":"Food Chem Toxicol"},{"issue":"10","key":"25_CR11","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1021\/jf020880w","volume":"51","author":"EA Bell","year":"2003","unstructured":"Bell EA (2003) Nonprotein amino acids of plants: significance in medicine, nutrition, and agriculture. J Agric Food Chem 51(10):2854\u20132865","journal-title":"J Agric Food Chem"},{"issue":"6","key":"25_CR12","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1056\/NEJMoa053085","volume":"354","author":"S Bent","year":"2006","unstructured":"Bent S et al (2006) Saw palmetto for benign prostatic hyperplasia. N Engl J Med 354(6):557\u2013566","journal-title":"N Engl J Med"},{"issue":"7","key":"25_CR13","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1046\/j.1464-410x.2000.00672.x","volume":"85","author":"RR Berges","year":"2000","unstructured":"Berges RR, Kassen A, Senge T (2000) Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int 85(7):842\u2013846","journal-title":"BJU Int"},{"issue":"1","key":"25_CR14","first-page":"36","volume":"9","author":"D Bhattacharyya","year":"2007","unstructured":"Bhattacharyya D et al (2007) Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report. Nepal Med Coll J 9(1):36\u201339","journal-title":"Nepal Med Coll J"},{"key":"25_CR15","doi-asserted-by":"crossref","unstructured":"Bi X et al (2017) Anti-inflammatory effects, SAR, and action mechanism of monoterpenoids from Radix Paeoniae Alba on LPS-stimulated RAW 264.7 cells. Molecules 22(5)","DOI":"10.3390\/molecules22050715"},{"key":"25_CR16","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.copbio.2017.07.002","volume":"48","author":"G Bian","year":"2017","unstructured":"Bian G, Deng Z, Liu T (2017) Strategies for terpenoid overproduction and new terpenoid discovery. Curr Opin Biotechnol 48:234\u2013241","journal-title":"Curr Opin Biotechnol"},{"key":"25_CR17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.foodchem.2014.08.083","volume":"170","author":"IF Bolarinwa","year":"2015","unstructured":"Bolarinwa IF, Orfila C, Morgan MR (2015) Determination of amygdalin in apple seeds, fresh apples and processed apple juices. Food Chem 170:437\u2013442","journal-title":"Food Chem"},{"key":"25_CR18","doi-asserted-by":"crossref","unstructured":"Bolarinwa IF et al (2016) A review of cyanogenic glycosides in edible plants. In: Soloneski S, Larramendy ML (eds) Toxicology\u2014new aspects to this scientific conundrum. IntechOpen","DOI":"10.5772\/64886"},{"key":"25_CR19","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.foodchem.2015.03.078","volume":"185","author":"DJ Bound","year":"2015","unstructured":"Bound DJ, Murthy PS, Srinivas P (2015) Synthesis and antibacterial properties of 2,3-dideoxyglucosides of terpene alcohols and phenols. Food Chem 185:192\u2013199","journal-title":"Food Chem"},{"issue":"5","key":"25_CR20","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s00436-010-2165-7","volume":"108","author":"FF Boyom","year":"2011","unstructured":"Boyom FF et al (2011) Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. Parasitol Res 108(5):1211\u20131217","journal-title":"Parasitol Res"},{"issue":"1","key":"25_CR21","first-page":"197","volume":"298","author":"S Carnesecchi","year":"2001","unstructured":"Carnesecchi S et al (2001) Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J Pharmacol Exp Ther 298(1):197\u2013200","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"25_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1128\/CMR.19.1.50-62.2006","volume":"19","author":"CF Carson","year":"2006","unstructured":"Carson CF, Hammer KA, Riley TV (2006) Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 19(1):50\u201362","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"25_CR23","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.foodchem.2008.09.001","volume":"113","author":"A Casta\u00f1eda-Ovando","year":"2009","unstructured":"Casta\u00f1eda-Ovando A et al (2009) Chemical studies of anthocyanins: a review. Food Chem 113(4):859\u2013871","journal-title":"Food Chem"},{"key":"25_CR24","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.msec.2016.07.040","volume":"68","author":"YW Chan","year":"2016","unstructured":"Chan YW et al (2016) Plasma polymerized carvone as an antibacterial and biocompatible coating. Mater Sci Eng C Mater Biol Appl 68:861\u2013871","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"10","key":"25_CR25","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.21873\/anticanres.11079","volume":"36","author":"C-D Chang","year":"2016","unstructured":"Chang C-D et al (2016) Ursolic acid suppresses hepatitis B virus X protein-mediated autophagy and chemotherapeutic drug resistance. Anticancer Res 36(10):5097","journal-title":"Anticancer Res"},{"issue":"2","key":"25_CR26","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1073\/pnas.1812935116","volume":"116","author":"AO Chatzivasileiou","year":"2019","unstructured":"Chatzivasileiou AO et al (2019) Two-step pathway for isoprenoid synthesis. Proc Natl Acad Sci USA 116(2):506","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"25_CR27","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1093\/jn\/131.12.3294","volume":"131","author":"D-Z Chen","year":"2001","unstructured":"Chen D-Z et al (2001) Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. J Nutr 131(12):3294\u20133302","journal-title":"J Nutr"},{"issue":"5","key":"25_CR28","first-page":"1580","volume":"5","author":"TC Chen","year":"2015","unstructured":"Chen TC, Fonseca COD, Sch\u00f6nthal AH (2015a) Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res 5(5):1580\u20131593","journal-title":"Am J Cancer Res"},{"key":"25_CR29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.lfs.2015.01.008","volume":"124","author":"X Chen","year":"2015","unstructured":"Chen X et al (2015b) IVSE, isolated from Inula japonica, suppresses LPS-induced NO production via NF-\u03baB and MAPK inactivation in RAW264.7 cells. Life Sci 124:8\u201315","journal-title":"Life Sci"},{"key":"25_CR30","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1038\/s41598-020-59451-z","volume":"10","author":"J Chen","year":"2020","unstructured":"Chen J et al (2020) Structure-antioxidant activity relationship of methoxy, phenolic hydroxyl, and carboxylic acid groups of phenolic acids. Sci Rep 10:2611","journal-title":"Sci Rep"},{"key":"25_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plaphy.2013.05.009","volume":"72","author":"V Cheynier","year":"2013","unstructured":"Cheynier V et al (2013) Plant phenolics: recent advances on their biosynthesis, genetics, and ecophysiology. Plant Physiol Biochem 72:1\u201320","journal-title":"Plant Physiol Biochem"},{"key":"25_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/BF02657682","volume":"68","author":"H Chimi","year":"1991","unstructured":"Chimi H et al (1991) Peroxyl and hydroxyl radical scavenging activity of some natural phenolic antioxidants. J Am Oil Chem Society 68:307\u2013312","journal-title":"J Am Oil Chem Society"},{"key":"25_CR33","doi-asserted-by":"crossref","unstructured":"Chiocchio I et al (2021) Plant secondary metabolites: an opportunity for circular economy. Molecules 26(2)","DOI":"10.3390\/molecules26020495"},{"issue":"5","key":"25_CR34","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.3892\/ijo.2016.3427","volume":"48","author":"M Cho","year":"2016","unstructured":"Cho M et al (2016) The antitumor effects of geraniol: modulation of cancer hallmark pathways (Review). Int J Oncol 48(5):1772\u20131782","journal-title":"Int J Oncol"},{"issue":"2","key":"25_CR35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/BF01945426","volume":"47","author":"MR Cholbi","year":"1991","unstructured":"Cholbi MR, Paya M, Alcaraz MJ (1991) Inhibitory effects of phenolic compounds on carbon tetrachloride-induced microsomal lipid peroxidation. Experientia 47(2):195\u2013199","journal-title":"Experientia"},{"issue":"6320","key":"25_CR36","doi-asserted-by":"publisher","first-page":"aag0804","DOI":"10.1126\/science.aag0804","volume":"355","author":"JM Clomburg","year":"2017","unstructured":"Clomburg JM, Crumbley AM, Gonzalez R (2017) Industrial biomanufacturing: the future of chemical production. Science 355(6320):aag0804","journal-title":"Science"},{"issue":"26","key":"25_CR37","doi-asserted-by":"publisher","first-page":"12810","DOI":"10.1073\/pnas.1821004116","volume":"116","author":"JM Clomburg","year":"2019","unstructured":"Clomburg JM et al (2019) The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis. Proc Natl Acad Sci USA 116(26):12810","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"25_CR38","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1038\/s41467-019-09848-w","volume":"10","author":"A Cravens","year":"2019","unstructured":"Cravens A, Payne J, Smolke CD (2019) Synthetic biology strategies for microbial biosynthesis of plant natural products. Nat Commun 10(1):2142","journal-title":"Nat Commun"},{"key":"25_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/247597","volume":"2012","author":"MP Crespo-Ortiz","year":"2012","unstructured":"Crespo-Ortiz MP, Wei MQ (2012) Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol 2012:247597","journal-title":"J Biomed Biotechnol"},{"issue":"1","key":"25_CR40","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1021\/acs.chemrev.1c00399","volume":"122","author":"L Cruz","year":"2022","unstructured":"Cruz L et al (2022) Natural and synthetic flavylium-based dyes: the chemistry behind the color. Chem Rev 122(1):1416\u20131481","journal-title":"Chem Rev"},{"issue":"1","key":"25_CR41","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3390\/molecules18011227","volume":"18","author":"R de C\u00e1ssia da Silveira e S\u00e1","year":"2013","unstructured":"de C\u00e1ssia da Silveira e S\u00e1 R, Andrade LN, de Sousa DP (2013) A review on anti-inflammatory activity of monoterpenes. Molecules 18(1):1227\u20131254","journal-title":"Molecules"},{"key":"25_CR42","doi-asserted-by":"crossref","unstructured":"De Gregorio C et al (2017) Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: results from a Pilot Strain-Echo Study. Nutrients 9(6)","DOI":"10.3390\/nu9060584"},{"key":"25_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109046","volume":"131","author":"J de Morais","year":"2020","unstructured":"de Morais J et al (2020) Antioxidant activity and bioaccessibility of phenolic compounds in white, red, blue, purple, yellow and orange edible flowers through a simulated intestinal barrier. Food Res Int 131:109046","journal-title":"Food Res Int"},{"issue":"5","key":"25_CR44","doi-asserted-by":"publisher","first-page":"AB13","DOI":"10.1016\/j.jaad.2014.01.054","volume":"70","author":"A Dermatology","year":"2014","unstructured":"Dermatology A (2014) A prospective split-face double-blind randomized placebo-controlled trial to assess the efficacy of vitamin C and ferulic acid serum postfractional ablative laser for skin rejuvenation. J Am Acad Dermatol 70(5):AB13","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"25_CR45","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3390\/molecules23061387","volume":"23","author":"IP De Sousa","year":"2018","unstructured":"De Sousa IP, Sousa Teixeira MV, Jacometti Cardoso Furtado NA (2018) An overview of biotransformation and toxicity of diterpenes. Molecules 23(6):1387","journal-title":"Molecules"},{"issue":"5090","key":"25_CR46","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"WA Devane","year":"1992","unstructured":"Devane WA et al (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258(5090):1946\u20131949","journal-title":"Science"},{"key":"25_CR47","doi-asserted-by":"crossref","unstructured":"Dey P et al (2020) Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids). Recent Adv Nat Prod Anal 505\u2013567","DOI":"10.1016\/B978-0-12-816455-6.00015-9"},{"key":"25_CR48","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.tifs.2020.10.033","volume":"107","author":"R Dias","year":"2021","unstructured":"Dias R et al (2021) Recent advances on dietary polyphenol\u2019s potential roles in Celiac disease. Trends Food Sci Technol 107:213\u2013225","journal-title":"Trends Food Sci Technol"},{"issue":"11-12","key":"25_CR49","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1515\/znc-2016-0033","volume":"72","author":"G Dogan","year":"2017","unstructured":"Dogan G et al (2017) Chemical composition and biological activities of leaf and fruit essential oils from Eucalyptus camaldulensis. Zeitschrift f\u00fcr Naturforschung C 72(11-12):483\u2013489","journal-title":"Zeitschrift f\u00fcr Naturforschung C"},{"issue":"4","key":"25_CR50","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.plipres.2013.07.001","volume":"52","author":"I Domonkos","year":"2013","unstructured":"Domonkos I et al (2013) Carotenoids, versatile components of oxygenic photosynthesis. Prog Lipid Res 52(4):539\u2013561","journal-title":"Prog Lipid Res"},{"issue":"12","key":"25_CR51","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.3390\/ijms11125323","volume":"11","author":"S Duangmano","year":"2010","unstructured":"Duangmano S et al (2010) Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc\/hTERT\/telomerase pathway and obstruction of the cell cycle. Int J Mol Sci 11(12):5323\u20135338","journal-title":"Int J Mol Sci"},{"issue":"1","key":"25_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/biot.201400330","volume":"10","author":"QM Dudley","year":"2015","unstructured":"Dudley QM, Karim AS, Jewett MC (2015) Cell-free metabolic engineering: biomanufacturing beyond the cell. Biotechnol J 10(1):69\u201382","journal-title":"Biotechnol J"},{"issue":"2","key":"25_CR53","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/BF02291540","volume":"33","author":"FN Dzhakhangirov","year":"1997","unstructured":"Dzhakhangirov FN et al (1997) Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship. Chem Nat Comp 33(2):190\u2013202","journal-title":"Chem Nat Comp"},{"issue":"3","key":"25_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0308-8146(83)90007-9","volume":"12","author":"S Dziedzic","year":"1983","unstructured":"Dziedzic S, Hudson B (1983) Polyhydroxy chalcones and flavanones as antioxidants for edible oils. Food Chem 12(3):205\u2013212","journal-title":"Food Chem"},{"issue":"5","key":"25_CR55","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3109\/10408441003610571","volume":"40","author":"T Efferth","year":"2010","unstructured":"Efferth T, Kaina B (2010) Toxicity of the antimalarial artemisinin and its derivatives. Crit Rev Toxicol 40(5):405\u2013421","journal-title":"Crit Rev Toxicol"},{"key":"25_CR56","doi-asserted-by":"crossref","unstructured":"Escobar-C\u00e9voli R et al (2017) An overview of global flavonoid intake and its food sources. In: Flavonoids-from biosynthesis to human health","DOI":"10.5772\/67655"},{"key":"25_CR57","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3389\/fonc.2019.00541","volume":"9","author":"K Esp\u00edndola","year":"2019","unstructured":"Esp\u00edndola K et al (2019) Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma. Front Oncol 9:541","journal-title":"Front Oncol"},{"key":"25_CR58","doi-asserted-by":"crossref","unstructured":"Feldo M et al (2019) Effect of diosmin administration in patients with chronic venous disorders on selected factors affecting angiogenesis. Molecules 24(18)","DOI":"10.3390\/molecules24183316"},{"key":"25_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2020.108326","volume":"178","author":"J-A Fenger","year":"2020","unstructured":"Fenger J-A et al (2020) The fate of acylated anthocyanins in mildly heated neutral solution. Dyes Pigment 178:108326","journal-title":"Dyes Pigment"},{"issue":"1","key":"25_CR60","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1104\/pp.103.038059","volume":"135","author":"K Forslund","year":"2004","unstructured":"Forslund K et al (2004) Biosynthesis of the nitrile glucosides rhodiocyanoside A and D and the cyanogenic glucosides lotaustralin and linamarin in Lotus japonicus. Plant Physiol 135(1):71\u201384","journal-title":"Plant Physiol"},{"issue":"10","key":"25_CR61","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s40265-013-0083-6","volume":"73","author":"JE Frampton","year":"2013","unstructured":"Frampton JE (2013) Crofelemer: a review of its use in the management of non-infectious diarrhoea in adult patients with HIV\/AIDS on antiretroviral therapy. Drugs 73(10):1121\u20131129","journal-title":"Drugs"},{"issue":"5","key":"25_CR62","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1080\/01635581.2014.916320","volume":"66","author":"M Galle","year":"2014","unstructured":"Galle M et al (2014) Suppression by geraniol of the growth of A549 human lung adenocarcinoma cells and inhibition of the mevalonate pathway in culture and in vivo: potential use in cancer chemotherapy. Nutr Cancer 66(5):888\u2013895","journal-title":"Nutr Cancer"},{"issue":"1","key":"25_CR63","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/157016310791162767","volume":"7","author":"R Graziose","year":"2010","unstructured":"Graziose R, Lila MA, Raskin I (2010) Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. Curr Drug Discov Technol 7(1):2\u201312","journal-title":"Curr Drug Discov Technol"},{"issue":"1","key":"25_CR64","first-page":"1","volume":"5","author":"R Gupta","year":"2007","unstructured":"Gupta R et al (2007) An overview of Indian novel traditional medicinal plants with anti-diabetic potentials. Afr J Tradit Complement Altern Med AJTCAM 5(1):1\u201317","journal-title":"Afr J Tradit Complement Altern Med AJTCAM"},{"key":"25_CR65","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.lfs.2015.02.021","volume":"128","author":"SL Guzm\u00e1n-Guti\u00e9rrez","year":"2015","unstructured":"Guzm\u00e1n-Guti\u00e9rrez SL et al (2015) Linalool and \u03b2-pinene exert their antidepressant-like activity through the monoaminergic pathway. Life Sci 128:24\u201329","journal-title":"Life Sci"},{"key":"25_CR66","series-title":"Plant ecophysiology","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-1-4020-2728-4_9","volume-title":"Nitrogen acquisition and assimilation in higher plants","author":"S Haneklaus","year":"2004","unstructured":"Haneklaus S, Schnug E (2004) Significance of secondary nitrogen metabolites for food quality. In: Am\u00e2ncio S, Stulen I (eds) Nitrogen acquisition and assimilation in higher plants, Plant ecophysiology, vol 3. Springer, Dordrecht, pp 231\u2013259. https:\/\/doi.org\/10.1007\/978-1-4020-2728-4_9"},{"key":"25_CR67","doi-asserted-by":"crossref","unstructured":"Hassan STS et al (2018) In vitro study of multi-therapeutic properties of Thymus bovei Benth. Essential oil and its main component for promoting their use in clinical practice. J Clin Med 7(9)","DOI":"10.3390\/jcm7090283"},{"issue":"10","key":"25_CR68","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","volume":"13","author":"KE Heim","year":"2002","unstructured":"Heim KE, Tagliaferro AR, Bobilya DJ (2002) Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 13(10):572\u2013584","journal-title":"J Nutr Biochem"},{"key":"25_CR69","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.foodchem.2014.10.057","volume":"173","author":"S Heleno","year":"2015","unstructured":"Heleno S et al (2015) Bioactivity of phenolic acids: metabolites versus parent compounds: a review. Food Chem 173:501\u2013513","journal-title":"Food Chem"},{"issue":"1","key":"25_CR70","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1748-1716.1951.tb00824.x","volume":"24","author":"H Hensel","year":"1951","unstructured":"Hensel H, Zotterman Y (1951) The effect of menthol on the thermoreceptors. Acta Physiol Scand 24(1):27\u201334","journal-title":"Acta Physiol Scand"},{"key":"25_CR71","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.tifs.2021.11.006","volume":"118","author":"D Herrera-Balandrano","year":"2021","unstructured":"Herrera-Balandrano D et al (2021) Blueberry anthocyanins: an updated review on approaches to enhancing their bioavailability. Trends Food Sci Technol 118:808\u2013821","journal-title":"Trends Food Sci Technol"},{"issue":"1","key":"25_CR72","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/0041-008X(91)90137-4","volume":"111","author":"JR Hincks","year":"1991","unstructured":"Hincks JR et al (1991) DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships. Toxicol Appl Pharmacol 111(1):90\u201398","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"25_CR73","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1105\/tpc.106.048694","volume":"19","author":"ME Hoballah","year":"2007","unstructured":"Hoballah ME et al (2007) Single gene-mediated shift in pollinator attraction in Petunia. Plant Cell 19(3):779\u2013790","journal-title":"Plant Cell"},{"issue":"5","key":"25_CR74","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1016\/j.juro.2010.12.091","volume":"185","author":"JL Hsu","year":"2011","unstructured":"Hsu JL et al (2011) Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer. J Urol 185(5):1967\u20131974","journal-title":"J Urol"},{"key":"25_CR75","unstructured":"Hussein RA, El-Anssary AA (2018) Plants secondary metabolites: the key drivers of the pharmacological actions of medicinal plants. In: Builders PF (ed) Herbal medicine. IntechOpen"},{"issue":"6","key":"25_CR76","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3390\/antibiotics9060330","volume":"9","author":"M Idrees","year":"2020","unstructured":"Idrees M et al (2020) Multimodal role of amino acids in microbial control and drug development. Antibiotics (Basel) 9(6):330","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"25_CR77","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0223-5234(99)80077-4","volume":"33","author":"K Iwasa","year":"1998","unstructured":"Iwasa K et al (1998) Antimalarial activity and structure-activity relationships of protoberberine alkaloids. Eur J Med Chem 33(1):65\u201369","journal-title":"Eur J Med Chem"},{"key":"25_CR78","first-page":"26","volume":"9","author":"K Jamwal","year":"2018","unstructured":"Jamwal K, Bhattacharya S, Puri S (2018) Plant growth regulator mediated consequences of secondary metabolites in medicinal plants. J Appl Res Med Aromat Plants 9:26\u201338","journal-title":"J Appl Res Med Aromat Plants"},{"issue":"10","key":"25_CR79","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.4155\/fmc.14.71","volume":"6","author":"DJ Jansen","year":"2014","unstructured":"Jansen DJ, Shenvi RA (2014) Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery. Future Med Chem 6(10):1127\u20131148","journal-title":"Future Med Chem"},{"issue":"4","key":"25_CR80","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1900\/RDS.2006.3.189","volume":"3","author":"PB Jeppesen","year":"2006","unstructured":"Jeppesen PB et al (2006) Can stevioside in combination with a soy-based dietary supplement be a new useful treatment of type 2 diabetes? An in vivo study in the diabetic goto-kakizaki rat. Rev Diabet Stud RDS 3(4):189\u2013199","journal-title":"Rev Diabet Stud RDS"},{"issue":"6","key":"25_CR81","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1111\/1541-4337.12836","volume":"20","author":"J Jokioja","year":"2021","unstructured":"Jokioja J, Yang B, Linderborg K (2021) Acylated anthocyanins: a review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation. Compr Rev Food Sci Food Saf 20(6):5570\u20135615","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"Suppl 1","key":"25_CR82","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1590\/S0074-02762011000900018","volume":"106","author":"FM Jord\u00e3o","year":"2011","unstructured":"Jord\u00e3o FM, Kimura EA, Katzin AM (2011) Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum. Mem Inst Oswaldo Cruz 106(Suppl 1):134\u2013141","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"3","key":"25_CR83","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1053\/rmed.2003.1432","volume":"97","author":"UR Juergens","year":"2003","unstructured":"Juergens UR et al (2003) Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial. Respir Med 97(3):250\u2013256","journal-title":"Respir Med"},{"key":"25_CR84","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/B978-0-444-63475-7.00002-9","volume-title":"Biotechnology for biofuel production and optimization","author":"A Kang","year":"2016","unstructured":"Kang A, Lee TS (2016) Chapter 2\u2014Secondary metabolism for isoprenoid-based biofuels. In: Eckert CA, Trinh CT (eds) Biotechnology for biofuel production and optimization. Elsevier, Amsterdam, pp 35\u201371"},{"key":"25_CR85","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ymben.2015.12.002","volume":"34","author":"A Kang","year":"2016","unstructured":"Kang A et al (2016) Isopentenyl diphosphate (IPP)-bypass mevalonate pathways for isopentenol production. Metab Eng 34:25\u201335","journal-title":"Metab Eng"},{"issue":"2","key":"25_CR86","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.aasci.2018.04.006","volume":"16","author":"M Kharadze","year":"2018","unstructured":"Kharadze M et al (2018) Anthocyanins and antioxidant activity of red wines made from endemic grape varieties. Ann Agrarian Sci 16(2):181\u2013184","journal-title":"Ann Agrarian Sci"},{"issue":"18","key":"25_CR87","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1128\/AEM.00845-13","volume":"79","author":"D Khokhani","year":"2013","unstructured":"Khokhani D et al (2013) Discovery of plant phenolic compounds that act as type III secretion system inhibitors or inducers of the fire blight pathogen, Erwinia amylovora. Appl Environ Microbiol 79(18):5424\u20135436","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"25_CR88","doi-asserted-by":"publisher","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","volume":"61","author":"HE Khoo","year":"2017","unstructured":"Khoo HE et al (2017) Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res 61(1):1361779","journal-title":"Food Nutr Res"},{"issue":"5","key":"25_CR89","first-page":"1683","volume":"40","author":"SH Kim","year":"2012","unstructured":"Kim SH et al (2012) Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. Int J Oncol 40(5):1683\u20131690","journal-title":"Int J Oncol"},{"issue":"1","key":"25_CR90","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4196\/kjpp.2015.19.1.21","volume":"19","author":"WS Kim","year":"2015","unstructured":"Kim WS et al (2015a) Anti-inflammatory, antioxidant and antimicrobial effects of artemisinin extracts from Artemisia annua L. Korean J Physiol Pharmacol 19(1):21\u201327","journal-title":"Korean J Physiol Pharmacol"},{"issue":"3","key":"25_CR91","doi-asserted-by":"publisher","first-page":"e0118800","DOI":"10.1371\/journal.pone.0118800","volume":"10","author":"S Kim","year":"2015","unstructured":"Kim S et al (2015b) Antimicrobial action of oleanolic acid on Listeria monocytogenes, Enterococcus faecium, and Enterococcus faecalis. PLoS One 10(3):e0118800\u2013e0118800","journal-title":"PLoS One"},{"issue":"4","key":"25_CR92","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jgr.2016.08.004","volume":"41","author":"JH Kim","year":"2017","unstructured":"Kim JH et al (2017) Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res 41(4):435\u2013443","journal-title":"J Ginseng Res"},{"key":"25_CR93","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ymben.2019.08.013","volume":"56","author":"J-E Kim","year":"2019","unstructured":"Kim J-E et al (2019) Tailoring the Saccharomyces cerevisiae endoplasmic reticulum for functional assembly of terpene synthesis pathway. Metab Eng 56:50\u201359","journal-title":"Metab Eng"},{"issue":"1","key":"25_CR94","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/mnfr.201100165","volume":"56","author":"II Koleva","year":"2012","unstructured":"Koleva II et al (2012) Alkaloids in the human food chain\u2013natural occurrence and possible adverse effects. Mol Nutr Food Res 56(1):30\u201352","journal-title":"Mol Nutr Food Res"},{"issue":"7","key":"25_CR95","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1021\/acs.jafc.8b06737","volume":"67","author":"I Krga","year":"2019","unstructured":"Krga I, Milenkovic D (2019) Anthocyanins: from sources and bioavailability to cardiovascular-health benefits and molecular mechanisms of action. J Agric Food Chem 67(7):1771\u20131783","journal-title":"J Agric Food Chem"},{"key":"25_CR96","doi-asserted-by":"publisher","first-page":"411","DOI":"10.2147\/IJWH.S7012","volume":"2","author":"S Kumar","year":"2010","unstructured":"Kumar S et al (2010) Clinical trials and progress with paclitaxel in ovarian cancer. Int J Womens Health 2:411\u2013427","journal-title":"Int J Womens Health"},{"issue":"1","key":"25_CR97","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2174\/1389203053027575","volume":"6","author":"F Lay","year":"2005","unstructured":"Lay F, Anderson M (2005) Defensins-components of the innate immune system in plants. Curr Protein Pept Sci 6(1):85\u2013101","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"25_CR98","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s12275-011-0195-1","volume":"45","author":"SB Lee","year":"2007","unstructured":"Lee SB et al (2007) The antimicrobial activity of essential oil from Dracocephalum foetidum against pathogenic microorganisms. J Microbiol 45(1):53\u201357","journal-title":"J Microbiol"},{"key":"25_CR99","doi-asserted-by":"crossref","unstructured":"Lee TK et al (2017) Pinecone of Pinus koraiensis inducing apoptosis in human lung cancer cells by activating caspase-3 and its chemical constituents. Chem Biodivers 14(4)","DOI":"10.1002\/cbdv.201600412"},{"issue":"6","key":"25_CR100","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/s10495-017-1353-7","volume":"22","author":"A Lewinska","year":"2017","unstructured":"Lewinska A et al (2017) Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. Apoptosis 22(6):800\u2013815","journal-title":"Apoptosis"},{"issue":"2","key":"25_CR101","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.synbio.2018.02.002","volume":"3","author":"J Li","year":"2018","unstructured":"Li J, Zhang L, Liu W (2018) Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products. Synth Syst Biotechnol 3(2):83\u201389","journal-title":"Synth Syst Biotechnol"},{"issue":"12","key":"25_CR102","first-page":"199","volume":"36","author":"J-x Li","year":"2020","unstructured":"Li J-x, Wu J-q, Cai Q-r (2020a) Research progresses on the synthetic biology of terpenes in Saccharomyces cerevisiae. Biotechnol Bull 36(12):199\u2013207","journal-title":"Biotechnol Bull"},{"issue":"1","key":"25_CR103","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/1541-4337.12516","volume":"19","author":"Z Li","year":"2020","unstructured":"Li Z et al (2020b) Sesquiterpenes in grapes and wines: occurrence, biosynthesis, functionality, and influence of winemaking processes. Compr Rev Food Sci Food Saf 19(1):247\u2013281","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"02n03","key":"25_CR104","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1142\/S0192415X02000338","volume":"30","author":"JG Lin","year":"2002","unstructured":"Lin JG et al (2002) Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells. Am J Chin Med 30(02n03):315\u2013325","journal-title":"Am J Chin Med"},{"issue":"13","key":"25_CR105","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.3390\/molecules24132512","volume":"24","author":"M Lin","year":"2019","unstructured":"Lin M et al (2019) Quinoa secondary metabolites and their biological activities or functions. Molecules 24(13):2512","journal-title":"Molecules"},{"key":"25_CR106","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/pharmaceutics12050419","volume":"12","author":"J Liu","year":"2020","unstructured":"Liu J et al (2020) Characterization of phenolic acid antimicrobial and antioxidant structure-property relationships. Pharmaceutics 12:419","journal-title":"Pharmaceutics"},{"key":"25_CR107","doi-asserted-by":"crossref","unstructured":"Lorigooini Z, Jamshidi-kia F, Dodman S (2020) Chapter 8\u2014Analysis of sesquiterpenes and sesquiterpenoids. In: Sanches Silva A et al (eds) Recent advances in natural products analysis. Elsevier, pp 289\u2013312","DOI":"10.1016\/B978-0-12-816455-6.00008-1"},{"key":"25_CR108","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ymben.2018.11.009","volume":"52","author":"T Ma","year":"2019","unstructured":"Ma T et al (2019) Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metab Eng 52:134\u2013142","journal-title":"Metab Eng"},{"issue":"1","key":"25_CR109","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-arplant-042811-105439","volume":"63","author":"H Maeda","year":"2012","unstructured":"Maeda H, Dudareva N (2012) The shikimate pathway and aromatic amino acid biosynthesis in plants. Annu Rev Plant Biol 63(1):73\u2013105","journal-title":"Annu Rev Plant Biol"},{"issue":"6243","key":"25_CR110","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1126\/science.aab0696","volume":"349","author":"JL Magnard","year":"2015","unstructured":"Magnard JL et al (2015) Plant volatiles. Biosynthesis of monoterpene scent compounds in roses. Science 349(6243):81\u201383","journal-title":"Science"},{"issue":"1","key":"25_CR111","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1475-2875-10-S1-S11","volume":"10","author":"MF Maia","year":"2011","unstructured":"Maia MF, Moore SJ (2011) Plant-based insect repellents: a review of their efficacy, development and testing. Malar J 10(1):S11","journal-title":"Malar J"},{"issue":"18","key":"25_CR112","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1080\/10408398.2016.1277971","volume":"57","author":"AF Majdalawieh","year":"2017","unstructured":"Majdalawieh AF, Fayyad MW, Nasrallah GK (2017) Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa. Crit Rev Food Sci Nutr 57(18):3911\u20133928","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"4","key":"25_CR113","doi-asserted-by":"publisher","first-page":"359","DOI":"10.4161\/psb.5.4.10871","volume":"5","author":"S Mandal","year":"2010","unstructured":"Mandal S, Chakraborty D, Dey S (2010) Phenolic acids act as signaling molecules in plant-microbe symbioses. Plant Signal Behav 5(4):359\u2013368","journal-title":"Plant Signal Behav"},{"issue":"2","key":"25_CR114","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10787-012-0139-3","volume":"21","author":"MH Mansour","year":"2013","unstructured":"Mansour MH et al (2013) Garlic (Allium sativum) down-regulates the expression of angiotensin II AT(1) receptor in adrenal and renal tissues of streptozotocin-induced diabetic rats. Inflammopharmacology 21(2):147\u2013159","journal-title":"Inflammopharmacology"},{"issue":"1","key":"25_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11418-019-01364-x","volume":"74","author":"T Maoka","year":"2020","unstructured":"Maoka T (2020) Carotenoids as natural functional pigments. J Nat Med 74(1):1\u201316","journal-title":"J Nat Med"},{"key":"25_CR116","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.foodchem.2014.06.056","volume":"166","author":"R Matera","year":"2015","unstructured":"Matera R et al (2015) Acylated anthocyanins from sprouts of Raphanus sativus cv. Sango: isolation, structure elucidation and antioxidant activity. Food Chem 166:397\u2013406","journal-title":"Food Chem"},{"issue":"2","key":"25_CR117","first-page":"232","volume":"3","author":"M Mazid","year":"2011","unstructured":"Mazid M, Khan T, Mohammad F (2011) Role of secondary metabolites in defense mechanisms of plants. Biol Med 3(2):232\u2013249","journal-title":"Biol Med"},{"issue":"3","key":"25_CR118","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/biomedicines7030062","volume":"7","author":"J Melrose","year":"2019","unstructured":"Melrose J (2019) The glucosinolates: a sulphur glucoside family of mustard anti-tumour and antimicrobial phytochemicals of potential therapeutic application. Biomedicines 7(3):62","journal-title":"Biomedicines"},{"key":"25_CR119","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1021\/acs.jpcb.8b01136","volume":"122","author":"J Mendoza","year":"2018","unstructured":"Mendoza J et al (2018) Rationalizing the color in heavenly blue anthocyanin: a complete kinetic and thermodynamic study. J Phys Chem B 122:4982\u20134992","journal-title":"J Phys Chem B"},{"issue":"6","key":"25_CR120","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1158\/1940-6207.CAPR-12-0452","volume":"6","author":"JA Miller","year":"2013","unstructured":"Miller JA et al (2013) Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer. Cancer Prev Res (Phila) 6(6):577\u2013584","journal-title":"Cancer Prev Res (Phila)"},{"key":"25_CR121","doi-asserted-by":"crossref","unstructured":"M\u00fccke M et al (2018) Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev (3)","DOI":"10.1002\/14651858.CD012182.pub2"},{"issue":"46","key":"25_CR122","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/BF01498120","volume":"27","author":"KO Mueller","year":"1939","unstructured":"Mueller KO, Meyer G, Klinkowski M (1939) Physiologisch-genetische Untersuchungen \u00fcber die Resistenz der Kartoffel gegen\u00fcber Phytophthora infestans. Naturwissenschaften 27(46):765\u2013768","journal-title":"Naturwissenschaften"},{"issue":"23","key":"25_CR123","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.2174\/1568026615666150619142519","volume":"15","author":"SF Nabavi","year":"2015","unstructured":"Nabavi SF et al (2015) Curcumin: a natural product for diabetes and its complications. Curr Top Med Chem 15(23):2445\u20132455","journal-title":"Curr Top Med Chem"},{"issue":"4","key":"25_CR124","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1021\/jf980737w","volume":"47","author":"F Nattela","year":"1999","unstructured":"Nattela F et al (1999) Benzoic and cinnamic acid derivatives as antioxidants: structure\u2212activity relation. J Agric Food Chem 47(4):1453\u20131459","journal-title":"J Agric Food Chem"},{"issue":"9","key":"25_CR125","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.3390\/ijms22094709","volume":"22","author":"Q-M Nguyen","year":"2021","unstructured":"Nguyen Q-M et al (2021) Recent advances in effector-triggered immunity in plants: new pieces in the puzzle create a different paradigm. Int J Mol Sci 22(9):4709","journal-title":"Int J Mol Sci"},{"issue":"6 Suppl","key":"25_CR126","doi-asserted-by":"publisher","first-page":"181","DOI":"10.4269\/ajtmh.2007.77.181","volume":"77","author":"F Nosten","year":"2007","unstructured":"Nosten F, White NJ (2007) Artemisinin-based combination treatment of falciparum malaria. Am J Trop Med Hyg 77(6 Suppl):181\u2013192","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"25_CR127","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1021\/np030498t","volume":"67","author":"NH Oberlies","year":"2004","unstructured":"Oberlies NH, Kroll DJ (2004) Camptothecin and taxol: historic achievements in natural products research. J Nat Prod 67(2):129\u2013135","journal-title":"J Nat Prod"},{"key":"25_CR128","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.foodchem.2019.02.132","volume":"288","author":"H Oliveira","year":"2019","unstructured":"Oliveira H et al (2019) Purple-fleshed sweet potato acylated anthocyanins: equilibrium network and photophysical properties. Food Chem 288:386\u2013394","journal-title":"Food Chem"},{"issue":"1","key":"25_CR129","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1186\/s40064-016-3283-1","volume":"5","author":"YJ Park","year":"2016","unstructured":"Park YJ et al (2016) Composition of volatile compounds and in vitro antimicrobial activity of nine Mentha spp. SpringerPlus 5(1):1628","journal-title":"SpringerPlus"},{"key":"25_CR130","first-page":"3","volume-title":"Flavour development, analysis and perception in food and beverages","author":"JK Parker","year":"2015","unstructured":"Parker JK (2015) 1\u2014Introduction to aroma compounds in foods. In: Parker JK, Elmore JS, Methven L (eds) Flavour development, analysis and perception in food and beverages. Woodhead, pp 3\u201330"},{"issue":"9","key":"25_CR131","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1002\/jsfa.7578","volume":"96","author":"K Pei","year":"2016","unstructured":"Pei K et al (2016) p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities. J Sci Food Agric 96(9):2952\u20132962","journal-title":"J Sci Food Agric"},{"key":"25_CR132","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.biopha.2015.02.028","volume":"71","author":"I Peluso","year":"2015","unstructured":"Peluso I, Palmery M (2015) Flavonoids at the pharma-nutrition interface: is a therapeutic index in demand? Biomed Pharmacother 71:102\u2013107","journal-title":"Biomed Pharmacother"},{"issue":"20","key":"25_CR133","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.tet.2014.09.051","volume":"71","author":"F Pina","year":"2015","unstructured":"Pina F, Oliveira J, de Freitas V (2015) Anthocyanins and derivatives are more than flavylium cations. Tetrahedron 71(20):14","journal-title":"Tetrahedron"},{"key":"25_CR134","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/978-3-662-44185-5_1070","volume-title":"Encyclopedia of astrobiology","author":"S Pizzarello","year":"2015","unstructured":"Pizzarello S (2015) Nonprotein amino acids. In: Gargaud M et al (eds) Encyclopedia of astrobiology. Springer, Berlin, pp 1697\u20131702"},{"issue":"28","key":"25_CR135","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.2174\/092986706779010333","volume":"13","author":"D Poeckel","year":"2006","unstructured":"Poeckel D, Werz O (2006) Boswellic acids: biological actions and molecular targets. Curr Med Chem 13(28):3359\u20133369","journal-title":"Curr Med Chem"},{"issue":"4","key":"25_CR136","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/sj.bjp.0706366","volume":"146","author":"D Poeckel","year":"2005","unstructured":"Poeckel D et al (2005) Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol 146(4):514\u2013524","journal-title":"Br J Pharmacol"},{"key":"25_CR137","first-page":"141","volume-title":"Autoxidation of unsaturated lipids","author":"J Pokorny","year":"1987","unstructured":"Pokorny J (1987) Major factors affecting the antioxidant of lipids. In: Chand H (ed) Autoxidation of unsaturated lipids. Academic, London, pp 141\u2013206"},{"issue":"7","key":"25_CR138","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009698","volume":"17","author":"G Polturak","year":"2021","unstructured":"Polturak G, Osbourn A (2021) The emerging role of biosynthetic gene clusters in plant defense and plant interactions. PLoS Pathog 17(7):e1009698","journal-title":"PLoS Pathog"},{"key":"25_CR139","doi-asserted-by":"publisher","first-page":"237","DOI":"10.5209\/rev_LAZA.2013.v34.n1.43298","volume":"34","author":"M Porres-martinez","year":"2013","unstructured":"Porres-martinez M, Accame MEC, G\u00f3mez-Serranillos M (2013) Pharmacological activity of Salvia lavandulifolia and chemical components of its essential oil. A review. Lazaroa 34:237\u2013254","journal-title":"Lazaroa"},{"issue":"18","key":"25_CR140","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.2174\/1385272821666170207114214","volume":"21","author":"Z-X Qing","year":"2017","unstructured":"Qing Z-X et al (2017) Isoquinoline alkaloids and their antiviral, antibacterial, and antifungal activities and structure-activity relationship. Curr Org Chem 21(18):1920\u20131934","journal-title":"Curr Org Chem"},{"key":"25_CR141","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109298","volume":"136","author":"HB Rashmi","year":"2020","unstructured":"Rashmi HB, Negi PS (2020) Phenolic acids from vegetables: a review on processing stability and health benefits. Food Res Int 136:109298","journal-title":"Food Res Int"},{"issue":"2","key":"25_CR142","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.3390\/molecules18021418","volume":"18","author":"A Rasul","year":"2013","unstructured":"Rasul A et al (2013) Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules 18(2):1418\u20131433","journal-title":"Molecules"},{"key":"25_CR143","doi-asserted-by":"crossref","unstructured":"Reynolds WF, Enriquez RG (2017) Chapter 7\u2014Terpenes: mono-, sesqui-, and higher terpenes. In: Modern NMR approaches to the structure elucidation of natural products: Volume 2: Data acquisition and applications to compound classes. The Royal Society of Chemistry, pp 251\u2013274","DOI":"10.1039\/9781849734684-00251"},{"issue":"15","key":"25_CR144","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.15252\/embj.201489108","volume":"33","author":"L Ribas de Pouplana","year":"2014","unstructured":"Ribas de Pouplana L (2014) Not an inside job: non-coded amino acids compromise the genetic code. EMBO J 33(15):1619\u20131620","journal-title":"EMBO J"},{"issue":"7","key":"25_CR145","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/0891-5849(95)02227-9","volume":"20","author":"C Rice-Evans","year":"1996","unstructured":"Rice-Evans C, Miller N, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20(7):933\u2013956","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"25_CR146","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1093\/ajcn\/80.1.171","volume":"80","author":"M Richelle","year":"2004","unstructured":"Richelle M et al (2004) Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of beta-carotene and alpha-tocopherol in normocholesterolemic humans. Am J Clin Nutr 80(1):171\u2013177","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"25_CR147","first-page":"1472","volume":"19","author":"K Ried","year":"2020","unstructured":"Ried K (2020) Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: a review and meta-analysis. Exp Ther Med 19(2):1472\u20131478","journal-title":"Exp Ther Med"},{"issue":"6","key":"25_CR148","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.jand.2019.11.007","volume":"120","author":"A Romanos-Nanclares","year":"2020","unstructured":"Romanos-Nanclares A et al (2020) Phenolic acid subclasses, individual compounds, and breast cancer risk in a mediterranean cohort: the SUN Project. J Acad Nutr Diet 120(6):1002\u20131015.e5","journal-title":"J Acad Nutr Diet"},{"key":"25_CR149","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/192464","volume":"2012","author":"SN Saldanha","year":"2012","unstructured":"Saldanha SN, Tollefsbol TO (2012) The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. J Oncol 2012:192464","journal-title":"J Oncol"},{"key":"25_CR150","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3390\/molecules22030358","volume":"22","author":"J Santana-G\u00e1lvez","year":"2017","unstructured":"Santana-G\u00e1lvez J, Cisneros-Zevallos L, Jacobo-Vel\u00e1zquez D (2017) Chlorogenic acid: recent advances on its dual role as a food additive and a nutraceutical against metabolic syndrome. Molecules 22:358","journal-title":"Molecules"},{"key":"25_CR151","doi-asserted-by":"publisher","first-page":"9329","DOI":"10.1021\/jf061750g","volume":"54","author":"NP Seeram","year":"2006","unstructured":"Seeram NP et al (2006) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem 54:9329\u20139339","journal-title":"J Agric Food Chem"},{"key":"25_CR152","volume":"2015","author":"Y Shahbazi","year":"2015","unstructured":"Shahbazi Y (2015) Chemical composition and in vitro antibacterial activity of Mentha spicata essential oil against common food-borne pathogenic bacteria. J Pathog 2015:916305","journal-title":"J Pathog"},{"key":"25_CR153","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.foodchem.2013.07.042","volume":"143","author":"Y Shao","year":"2014","unstructured":"Shao Y et al (2014) Phenolic acids, anthocyanins, and antioxidant capacity in rice (Oryza sativa L.) grains at four stages of development after flowering. Food Chem 143:90\u201396","journal-title":"Food Chem"},{"issue":"1","key":"25_CR154","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/molecules22010070","volume":"22","author":"J Sharifi-Rad","year":"2017","unstructured":"Sharifi-Rad J et al (2017) Biological activities of essential oils: from plant chemoecology to traditional healing systems. Molecules 22(1):70","journal-title":"Molecules"},{"issue":"2","key":"25_CR155","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.lwt.2005.09.018","volume":"40","author":"F Silva","year":"2007","unstructured":"Silva F et al (2007) Anthocyanin pigments in strawberry. LWT Food Sci Technol 40(2):374\u2013382","journal-title":"LWT Food Sci Technol"},{"key":"25_CR156","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/978-981-10-7371-7_14","volume-title":"Molecular aspects of plant-pathogen interaction","author":"SK Singh","year":"2018","unstructured":"Singh SK (2018) Explorations of plant\u2019s chemodiversity: role of nitrogen-containing secondary metabolites in plant defense. In: Singh A, Singh IK (eds) Molecular aspects of plant-pathogen interaction. Springer, Singapore, pp 309\u2013332"},{"issue":"2","key":"25_CR157","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s13205-014-0220-2","volume":"5","author":"B Singh","year":"2015","unstructured":"Singh B, Sharma RA (2015) Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications. 3 Biotech 5(2):129\u2013151","journal-title":"3 Biotech"},{"issue":"4","key":"25_CR158","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/10715760500540442","volume":"40","author":"C Siquet","year":"2006","unstructured":"Siquet C et al (2006) Antioxidant profile of dihydroxy- and trihydroxyphenolic acids-A structure\u2013activity relationship study. Free Radic Res 40(4):433\u2013442","journal-title":"Free Radic Res"},{"key":"25_CR159","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/953451","volume":"2014","author":"MV Sobral","year":"2014","unstructured":"Sobral MV et al (2014) Antitumor activity of monoterpenes found in essential oils. ScientificWorldJournal 2014:953451","journal-title":"ScientificWorldJournal"},{"issue":"5","key":"25_CR160","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.tplants.2010.02.005","volume":"15","author":"IE S\u00f8nderby","year":"2010","unstructured":"S\u00f8nderby IE, Geu-Flores F, Halkier BA (2010) Biosynthesis of glucosinolates\u2014gene discovery and beyond. Trends Plant Sci 15(5):283\u2013290","journal-title":"Trends Plant Sci"},{"issue":"1","key":"25_CR161","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00404-014-3408-0","volume":"291","author":"Y Song","year":"2015","unstructured":"Song Y et al (2015) Sequential combination of flavopiridol with Taxol synergistically suppresses human ovarian carcinoma growth. Arch Gynecol Obstet 291(1):143\u2013150","journal-title":"Arch Gynecol Obstet"},{"issue":"5","key":"25_CR162","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1093\/pcp\/pcq031","volume":"51","author":"O Sozer","year":"2010","unstructured":"Sozer O et al (2010) Involvement of carotenoids in the synthesis and assembly of protein subunits of photosynthetic reaction centers of Synechocystis sp. PCC 6803. Plant Cell Physiol 51(5):823\u2013835","journal-title":"Plant Cell Physiol"},{"key":"25_CR163","doi-asserted-by":"publisher","first-page":"6172","DOI":"10.1021\/jf0204811","volume":"50","author":"FC Stintzing","year":"2002","unstructured":"Stintzing FC et al (2002) Color and antioxidant properties of cyanidin-based anthocyanin pigments. J Agric Food Chem 50:6172\u20136181","journal-title":"J Agric Food Chem"},{"issue":"5","key":"25_CR164","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/ptr.2980","volume":"24","author":"F Subhan","year":"2010","unstructured":"Subhan F et al (2010) Terpenoid content of Valeriana wallichii extracts and antidepressant-like response profiles. Phytother Res 24(5):686\u2013691","journal-title":"Phytother Res"},{"issue":"18","key":"25_CR165","doi-asserted-by":"publisher","first-page":"4111","DOI":"10.3390\/molecules25184111","volume":"25","author":"MS Subramanian","year":"2020","unstructured":"Subramanian MS et al (2020) Prevailing knowledge on the bioavailability and biological activities of sulphur compounds from alliums: a potential drug candidate. Molecules 25(18):4111","journal-title":"Molecules"},{"issue":"3","key":"25_CR166","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1002\/jcp.26125","volume":"233","author":"NK Sun","year":"2018","unstructured":"Sun NK et al (2018a) TLR4 and NF\u03baB signaling is critical for taxol resistance in ovarian carcinoma cells. J Cell Physiol 233(3):2489\u20132501","journal-title":"J Cell Physiol"},{"issue":"1","key":"25_CR167","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00253-017-8559-z","volume":"102","author":"Z Sun","year":"2018","unstructured":"Sun Z et al (2018b) Biosynthesis and regulation of cyanogenic glycoside production in forage plants. Appl Microbiol Biotechnol 102(1):9\u201316","journal-title":"Appl Microbiol Biotechnol"},{"key":"25_CR168","volume-title":"Alkaloids: chemistry, biology, ecology, and applications","author":"A Tadeusz","year":"2015","unstructured":"Tadeusz A (2015) Alkaloids: chemistry, biology, ecology, and applications, vol 13. Elsevier, Amsterdam. 978-0444594334"},{"key":"25_CR169","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1744-8069-8-86","volume":"8","author":"M Takaishi","year":"2012","unstructured":"Takaishi M et al (2012) 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain 8:86","journal-title":"Mol Pain"},{"key":"25_CR170","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/251754","volume":"2013","author":"J Teixeira","year":"2013","unstructured":"Teixeira J et al (2013) Hydroxycinnamic acid antioxidants: an electrochemical overview. Biomed Res Int 2013:251754","journal-title":"Biomed Res Int"},{"key":"25_CR171","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/antiox9050451","volume":"9","author":"N Tena","year":"2020","unstructured":"Tena N, Mart\u00edn J, Asuero A (2020) State of the art of anthocyanins: antioxidant activity, sources, bioavailability, and therapeutic effect in human health. Antioxidants 9:45","journal-title":"Antioxidants"},{"issue":"11","key":"25_CR172","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/toxins11110656","volume":"11","author":"A Thawabteh","year":"2019","unstructured":"Thawabteh A et al (2019) The biological activity of natural alkaloids against herbivores, cancerous cells and pathogens. Toxins 11(11):656","journal-title":"Toxins"},{"issue":"1","key":"25_CR173","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev-arplant-050312-120229","volume":"65","author":"R Thimmappa","year":"2014","unstructured":"Thimmappa R et al (2014) Triterpene biosynthesis in plants. Annu Rev Plant Biol 65(1):225\u2013257","journal-title":"Annu Rev Plant Biol"},{"key":"25_CR174","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103533","volume":"70","author":"Z Tian","year":"2021","unstructured":"Tian Z et al (2021) Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: a randomized clinical trial. EBioMedicine 70:103533","journal-title":"EBioMedicine"},{"key":"25_CR175","doi-asserted-by":"crossref","unstructured":"Tuladhar P, Sasidharan S, Saudagar P (2021) Role of phenols and polyphenols in plant defense response to biotic and abiotic stresses. In: Biocontrol agents and secondary metabolites: applications and immunization for plant growth and protection. Woodhead, pp 419\u2013441","DOI":"10.1016\/B978-0-12-822919-4.00017-X"},{"key":"25_CR176","doi-asserted-by":"crossref","unstructured":"Vankar P, Srivastava J (2010) Evaluation of anthocyanin content in red and blue flowers. Int J Food Eng 6(4)","DOI":"10.2202\/1556-3758.1907"},{"issue":"1","key":"25_CR177","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0041-0101(99)00128-2","volume":"38","author":"J Vetter","year":"2000","unstructured":"Vetter J (2000) Plant cyanogenic glycosides. Toxicon 38(1):11\u201336","journal-title":"Toxicon"},{"issue":"10","key":"25_CR178","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1093\/jxb\/err031","volume":"62","author":"MR Vicente","year":"2011","unstructured":"Vicente MR, Plasencia J (2011) Salicylic acid beyond defence: its role in plant growth and development. J Exp Bot 62(10):3321\u20133338","journal-title":"J Exp Bot"},{"key":"25_CR179","doi-asserted-by":"crossref","unstructured":"Vuolo MM, Lima VS, Mar\u00f3stica-Jr MR (2019) Phenolic compounds: structure, classification, and antioxidant power. In: Bioactive compounds: health benefits and potential applications. Woodhead, pp 33\u201350","DOI":"10.1016\/B978-0-12-814774-0.00002-5"},{"key":"25_CR180","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jep.2017.03.039","volume":"203","author":"CS Wagner","year":"2017","unstructured":"Wagner CS et al (2017) Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript. J Ethnopharmacol 203:171\u2013181","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"25_CR181","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s10753-014-0056-2","volume":"38","author":"X Wang","year":"2015","unstructured":"Wang X et al (2015) Inhibitory effects of JEUD-38, a new sesquiterpene lactone from Inula japonica Thunb, on LPS-induced iNOS expression in RAW264.7 cells. Inflammation 38(3):941\u2013948","journal-title":"Inflammation"},{"issue":"9","key":"25_CR182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163147","volume":"11","author":"T-H Wang","year":"2016","unstructured":"Wang T-H et al (2016) Evaluation of the antibacterial potential of liquid and vapor phase phenolic essential oil compounds against oral microorganisms. PLoS One 11(9):e0163147","journal-title":"PLoS One"},{"issue":"4","key":"25_CR183","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.3892\/ijo.2017.3890","volume":"50","author":"S Wang","year":"2017","unstructured":"Wang S, Meng X, Dong Y (2017) Ursolic acid nanoparticles inhibit cervical cancer growth in vitro and in vivo via apoptosis induction. Int J Oncol 50(4):1330\u20131340","journal-title":"Int J Oncol"},{"key":"25_CR184","doi-asserted-by":"crossref","unstructured":"Wang C et al (2018) Microbial platform for terpenoid production: Escherichia coli and yeast. Front Microbiol 9","DOI":"10.3389\/fmicb.2018.02460"},{"issue":"1","key":"25_CR185","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41421-018-0075-5","volume":"5","author":"P Wang","year":"2019","unstructured":"Wang P et al (2019) Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency. Cell Discov 5(1):5","journal-title":"Cell Discov"},{"key":"25_CR186","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1034","volume":"374","author":"L Wang","year":"2021","unstructured":"Wang L et al (2021) Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials. BMJ 374:n1034","journal-title":"BMJ"},{"issue":"9","key":"25_CR187","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1021\/ja00738a045","volume":"93","author":"MC Wani","year":"1971","unstructured":"Wani MC et al (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93(9):2325\u20132327","journal-title":"J Am Chem Soc"},{"issue":"3","key":"25_CR188","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/nbu.12278","volume":"42","author":"G Williamson","year":"2017","unstructured":"Williamson G (2017) The role of polyphenols in modern nutrition. Nutr Bull 42(3):226\u2013235","journal-title":"Nutr Bull"},{"key":"25_CR189","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.foodchem.2017.10.122","volume":"245","author":"S Wu","year":"2018","unstructured":"Wu S et al (2018) Structure\u2013affinity relationship of the interaction between phenolic acids and their derivatives and \u03b2-lactoglobulin and effect on antioxidant activity. Food Chem 245:613\u2013619","journal-title":"Food Chem"},{"key":"25_CR190","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2021.105833","volume":"80","author":"W Wu","year":"2021","unstructured":"Wu W et al (2021) Simultaneous process optimization of ultrasound-assisted extraction of polyphenols and ellagic acid from pomegranate (Punica granatum L.) flowers and its biological activities. Ultrason Sonochem 80:105833","journal-title":"Ultrason Sonochem"},{"issue":"6","key":"25_CR191","doi-asserted-by":"publisher","first-page":"e00122-17","DOI":"10.1128\/AAC.00122-17","volume":"61","author":"YF Xu","year":"2017","unstructured":"Xu YF et al (2017) In vitro and in vivo antibacterial activities of patchouli alcohol, a naturally occurring tricyclic sesquiterpene, against Helicobacter pylori infection. Antimicrob Agents Chemother 61(6):e00122-17","journal-title":"Antimicrob Agents Chemother"},{"key":"25_CR192","doi-asserted-by":"publisher","first-page":"529881","DOI":"10.3389\/fphar.2020.529881","volume":"11","author":"C Xu","year":"2020","unstructured":"Xu C et al (2020) Artemisinins as anticancer drugs: novel therapeutic approaches, molecular mechanisms, and clinical trials. Front Pharmacol 11:529881","journal-title":"Front Pharmacol"},{"key":"25_CR193","doi-asserted-by":"crossref","unstructured":"Yamane H et al (2010) Chemical defence and toxins of plants","DOI":"10.1016\/B978-008045382-8.00099-X"},{"issue":"3","key":"25_CR194","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.ygyno.2011.08.031","volume":"123","author":"YI Yang","year":"2011","unstructured":"Yang YI et al (2011) Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species. Gynecol Oncol 123(3):588\u2013596","journal-title":"Gynecol Oncol"},{"key":"25_CR195","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ymben.2019.06.004","volume":"55","author":"DA Yee","year":"2019","unstructured":"Yee DA et al (2019) Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae. Metab Eng 55:76\u201384","journal-title":"Metab Eng"},{"issue":"3","key":"25_CR196","doi-asserted-by":"publisher","first-page":"719","DOI":"10.3390\/molecules26030719","volume":"26","author":"M Yulvianti","year":"2021","unstructured":"Yulvianti M, Zidorn C (2021) Chemical diversity of plant cyanogenic glycosides: an overview of reported natural products. Molecules (Basel, Switzerland) 26(3):719","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"8","key":"25_CR197","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1017\/S0007114513000688","volume":"110","author":"R Zamora-Ros","year":"2013","unstructured":"Zamora-Ros R et al (2013) Dietary intakes and food sources of phenolic acids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr 110(8):1500\u20131511","journal-title":"Br J Nutr"},{"issue":"3\u20134","key":"25_CR198","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000503410","volume":"105","author":"L Zhang","year":"2020","unstructured":"Zhang L et al (2020) Effect of andrographolide and its analogs on bacterial infection: a review. Pharmacology 105(3\u20134):123\u2013134","journal-title":"Pharmacology"},{"issue":"4","key":"25_CR199","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.foodchem.2008.02.039","volume":"109","author":"Z Zhao","year":"2008","unstructured":"Zhao Z, Moghadasian M (2008) Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review. Food Chem 109(4):691\u2013702","journal-title":"Food Chem"},{"issue":"3","key":"25_CR200","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s11030-014-9520-z","volume":"18","author":"CL Zhao","year":"2014","unstructured":"Zhao CL et al (2014) Structure-activity relationships of anthocyanidin glycosylation. Mol Divers 18(3):687\u2013700","journal-title":"Mol Divers"},{"issue":"7","key":"25_CR201","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s00192-014-2585-5","volume":"26","author":"M Zor","year":"2015","unstructured":"Zor M, Aydur E, Dmochowski RR (2015) Flavoxate in urogynecology: an old drug revisited. Int Urogynecol J 26(7):959\u2013966","journal-title":"Int Urogynecol J"}],"container-title":["Natural Secondary Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-18587-8_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T23:26:02Z","timestamp":1677194762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-18587-8_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9783031185861","9783031185878"],"references-count":201,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-18587-8_25","relation":{},"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"22 February 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}