{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:15:33Z","timestamp":1771362933536,"version":"3.50.1"},"publisher-location":"Cham","reference-count":75,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032031754","type":"print"},{"value":"9783032031761","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-03176-1_35","type":"book-chapter","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:48:23Z","timestamp":1762984103000},"page":"729-746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunomodulation Strategies to Enhance Oral Bone Regeneration"],"prefix":"10.1007","author":[{"given":"Miguel","family":"Cardoso","sequence":"first","affiliation":[]},{"given":"Farah","family":"Asa\u2019ad","sequence":"additional","affiliation":[]},{"given":"Teresa M. V. D.","family":"Pinho e Melo","sequence":"additional","affiliation":[]},{"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Pineiro","sequence":"additional","affiliation":[]},{"given":"Carlos Miguel","family":"Marto","sequence":"additional","affiliation":[]},{"given":"Mafalda","family":"Laranjo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"4","key":"35_CR1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s00520-024-08388-4","volume":"32","author":"A Abdolrahmani","year":"2024","unstructured":"Abdolrahmani A, Epstein JB, Samim F (2024) Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management. Support Care Cancer 32(4):212. https:\/\/doi.org\/10.1007\/s00520-024-08388-4","journal-title":"Support Care Cancer"},{"key":"35_CR2","doi-asserted-by":"crossref","unstructured":"Akens MK (2012) Photodynamic therapy treatment to enhance fracture healing","DOI":"10.21236\/ADA578788"},{"issue":"3","key":"35_CR3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s10103-017-2153-6","volume":"32","author":"G B\u00f6l\u00fckba\u015f\u0131 Ate\u015f","year":"2017","unstructured":"B\u00f6l\u00fckba\u015f\u0131 Ate\u015f G, Ak Can A, G\u00fclsoy M (2017) Investigation of photobiomodulation potentiality by 635 and 809 nm lasers on human osteoblasts. Lasers Med Sci 32(3):591\u2013599. https:\/\/doi.org\/10.1007\/s10103-017-2153-6","journal-title":"Lasers Med Sci"},{"issue":"19","key":"35_CR4","doi-asserted-by":"publisher","first-page":"e2100584","DOI":"10.1002\/advs.202100584","volume":"8","author":"B Cai","year":"2021","unstructured":"Cai B, Lin D, Li Y, Wang L, Xie J, Dai T, Liu F, Tang M, Tian L, Yuan Y, Kong L, Shen SGF (2021) N2-polarized neutrophils guide bone mesenchymal stem cell recruitment and initiate bone regeneration: a missing piece of the bone regeneration puzzle. Adv Sci (Weinh) 8(19):e2100584. https:\/\/doi.org\/10.1002\/advs.202100584","journal-title":"Adv Sci (Weinh)"},{"key":"35_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104242","volume":"48","author":"M Cardoso","year":"2024","unstructured":"Cardoso M, Marto CM, Paula A, Coelho AS, Amaro I, Pineiro M, Pinho E Melo TMVD, Marques Ferreira M, Botelho MF, Carrilho E, Laranjo M (2024) Effectiveness of photodynamic therapy on treatment response and survival in patients with recurrent oral squamous cell carcinoma: a systematic review. Photodiagn Photodyn Ther 48:104242. https:\/\/doi.org\/10.1016\/j.pdpdt.2024.104242","journal-title":"Photodiagn Photodyn Ther"},{"key":"35_CR6","doi-asserted-by":"publisher","unstructured":"Chou W, Sun T, Peng N, Wang Z, Chen D, Qiu H, Zhao H (2023) Photodynamic therapy-induced anti-tumor immunity: influence factors and synergistic enhancement strategies. Pharmaceutics 15(11). https:\/\/doi.org\/10.3390\/pharmaceutics15112617","DOI":"10.3390\/pharmaceutics15112617"},{"issue":"3","key":"35_CR7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.34172\/jlms.2020.57","volume":"11","author":"N Derikvand","year":"2020","unstructured":"Derikvand N, Hatami M, Chiniforush N, Ghasemi SS (2020) The use of antimicrobial photodynamic therapy to maintain a hopeless tooth with a periodonticendodontic lesion: a case report. J Lasers Med Sci 11(3):355\u2013360. https:\/\/doi.org\/10.34172\/jlms.2020.57","journal-title":"J Lasers Med Sci"},{"issue":"2","key":"35_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2019.07.003","volume":"1872","author":"C Donohoe","year":"2019","unstructured":"Donohoe C, Senge MO, Arnaut LG, Gomes-da-Silva LC (2019) Cell death in photodynamic therapy: from oxidative stress to anti-tumor immunity. Biochim Biophys Acta 1872(2):188308. https:\/\/doi.org\/10.1016\/j.bbcan.2019.07.003","journal-title":"Biochim Biophys Acta"},{"issue":"S21","key":"35_CR9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/jcpe.13048","volume":"46","author":"N Donos","year":"2019","unstructured":"Donos N, Dereka X, Calciolari E (2019) The use of bioactive factors to enhance bone regeneration: a narrative review. J Clin Periodontol 46(S21):124\u2013161. https:\/\/doi.org\/10.1111\/jcpe.13048","journal-title":"J Clin Periodontol"},{"issue":"1","key":"35_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/prd.12518","volume":"93","author":"N Donos","year":"2023","unstructured":"Donos N, Akcali A, Padhye N, Sculean A, Calciolari E (2023) Bone regeneration in implant dentistry: which are the factors affecting the clinical outcome? Periodontol 93(1):26\u201355. https:\/\/doi.org\/10.1111\/prd.12518","journal-title":"Periodontol"},{"key":"35_CR11","doi-asserted-by":"publisher","first-page":"1335920","DOI":"10.3389\/fimmu.2024.1335920","volume":"15","author":"T Dudzik","year":"2024","unstructured":"Dudzik T, Doma\u0144ski I, Makuch S (2024) The impact of photodynamic therapy on immune system in cancer \u2013 an update. Front Immunol 15:1335920. https:\/\/doi.org\/10.3389\/fimmu.2024.1335920","journal-title":"Front Immunol"},{"issue":"5","key":"35_CR12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/eos.12364","volume":"125","author":"I Elgali","year":"2017","unstructured":"Elgali I, Omar O, Dahlin C, Thomsen P (2017) Guided bone regeneration: materials and biological mechanisms revisited. Eur J Oral Sci 125(5):315\u2013337. https:\/\/doi.org\/10.1111\/eos.12364","journal-title":"Eur J Oral Sci"},{"key":"35_CR13","doi-asserted-by":"publisher","first-page":"1020995","DOI":"10.3389\/fmicb.2022.1020995","volume":"13","author":"L Gholami","year":"2022","unstructured":"Gholami L, Shahabi S, Jazaeri M, Hadilou M, Fekrazad R (2022) Clinical applications of antimicrobial photodynamic therapy in dentistry. Front Microbiol 13:1020995. https:\/\/doi.org\/10.3389\/fmicb.2022.1020995","journal-title":"Front Microbiol"},{"issue":"S21","key":"35_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/jcpe.13130","volume":"46","author":"WV Giannobile","year":"2019","unstructured":"Giannobile WV, Berglundh T, Al-Nawas B, Araujo M, Bartold PM, Bouchard P, Chapple I, Gruber R, Lundberg P, Sculean A, Lang NP, Lyngstadaas P, Kebschull M, Galindo-Moreno P, Schwartz Z, Shapira L, Stavropoulos A, Reseland J (2019) Biological factors involved in alveolar bone regeneration. J Clin Periodontol 46(S21):6\u201311. https:\/\/doi.org\/10.1111\/jcpe.13130","journal-title":"J Clin Periodontol"},{"issue":"79","key":"35_CR15","doi-asserted-by":"publisher","first-page":"50200","DOI":"10.1039\/C7RA09308J","volume":"7","author":"Z Hao","year":"2017","unstructured":"Hao Z, Ma Y, Wu J, Li X, Chen H, Shen J et al (2017) Osteocytes regulate osteoblast differentiation and osteoclast activity through Interleukin-6 under mechanical loading. RSC Adv 7(79):50200\u201350209. https:\/\/doi.org\/10.1039\/C7RA09308J","journal-title":"RSC Adv"},{"issue":"23","key":"35_CR16","doi-asserted-by":"publisher","first-page":"13016","DOI":"10.3390\/ijms222313016","volume":"22","author":"TDK Herath","year":"2021","unstructured":"Herath TDK, Saigo L, Schaller B, Larbi A, Teoh SH, Kirkpatrick CJ, Goh BT (2021) In vivo efficacy of neutrophil-mediated bone regeneration using a rabbit calvarial defect model. Int J Mol Sci 22(23):13016. https:\/\/doi.org\/10.3390\/ijms222313016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"35_CR17","first-page":"78","volume":"14","author":"NX Jain","year":"2014","unstructured":"Jain NX, Barr-Gillespie AE, Clark BD, Kietrys DM, Wade CK, Litvin J, Popoff SN, Barbe MF (2014) Bone loss from high repetitive high force loading is prevented by ibuprofen treatment. J Musculoskelet Neuronal Interact 14(1):78\u201394. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24583543","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"7","key":"35_CR18","doi-asserted-by":"publisher","first-page":"4483","DOI":"10.1111\/odi.14849","volume":"30","author":"T Jiang","year":"2024","unstructured":"Jiang T, Tang X-Y, Su H, Chen J-Y, Qin Y-Q, Qin Y-C, Ouyang N-J, Tang G-H (2024) Neutrophils are involved in early bone formation during midpalatal expansion. Oral Dis 30(7):4483\u20134494. https:\/\/doi.org\/10.1111\/odi.14849","journal-title":"Oral Dis"},{"issue":"4","key":"35_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s13770-020-00324-x","volume":"18","author":"M Kim","year":"2021","unstructured":"Kim M, Shin DI, Choi BH, Min BH (2021) Exosomes from IL-1\u03b2-primed mesenchymal stem cells inhibited IL-1\u03b2- and TNF-\u03b1-mediated inflammatory responses in osteoarthritic SW982 cells. Tissue Eng Regen Med 18(4):525\u2013536. https:\/\/doi.org\/10.1007\/s13770-020-00324-x","journal-title":"Tissue Eng Regen Med"},{"issue":"5","key":"35_CR20","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s10103-017-2426-0","volume":"33","author":"R Kunimatsu","year":"2018","unstructured":"Kunimatsu R, Gunji H, Tsuka Y, Yoshimi Y, Awada T, Sumi K, Nakajima K, Kimura A, Hiraki T, Abe T, Naoto H, Yanoshita M, Tanimoto K (2018) Effects of high-frequency near-infrared diode laser irradiation on the proliferation and migration of mouse calvarial osteoblasts. Lasers Med Sci 33(5):959\u2013966. https:\/\/doi.org\/10.1007\/s10103-017-2426-0","journal-title":"Lasers Med Sci"},{"issue":"26","key":"35_CR21","doi-asserted-by":"publisher","first-page":"5221","DOI":"10.1039\/d1tb00559f","volume":"9","author":"B Kupikowska-Stobba","year":"2021","unstructured":"Kupikowska-Stobba B, Kasprzak M (2021) Fabrication of nanoparticles for bone regeneration: new insight into applications of nanoemulsion technology. J Mater Chem B 9(26):5221\u20135244. https:\/\/doi.org\/10.1039\/d1tb00559f","journal-title":"J Mater Chem B"},{"issue":"1","key":"35_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s41232-023-00279-1","volume":"43","author":"J Kushioka","year":"2023","unstructured":"Kushioka J, Chow SK-H, Toya M, Tsubosaka M, Shen H, Gao Q, Li X, Zhang N, Goodman SB (2023) Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy. Inflamm Regen 43(1):29. https:\/\/doi.org\/10.1186\/s41232-023-00279-1","journal-title":"Inflamm Regen"},{"key":"35_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112468","volume":"200","author":"M Laranjo","year":"2020","unstructured":"Laranjo M, Aguiar M, Pereira N, Brites G, Nascimento B, Brito A, Casalta-Lopes J, Gon\u00e7alves AC, Sarmento-Ribeiro AB, Pineiro M, Botelho MF, Pinho e Melo T (2020) Platinum(II) ring-fused chlorins as efficient theranostic agents: dyes for tumor-imaging and photodynamic therapy of cancer. Eur J Med Chem 200:112468. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112468","journal-title":"Eur J Med Chem"},{"issue":"4","key":"35_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801106","volume":"8","author":"J Lee","year":"2019","unstructured":"Lee J, Byun H, Madhurakkat Perikamana SK, Lee S, Shin H (2019) Current advances in immunomodulatory biomaterials for bone regeneration. Adv Healthc Mater 8(4):e1801106. https:\/\/doi.org\/10.1002\/adhm.201801106","journal-title":"Adv Healthc Mater"},{"key":"35_CR25","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3389\/fimmu.2018.00585","volume":"9","author":"J Li","year":"2018","unstructured":"Li J, Tan J, Martino MM, Lui KO (2018) Regulatory T-cells: potential regulator of tissue repair and regeneration. Front Immunol 9:585. https:\/\/doi.org\/10.3389\/fimmu.2018.00585","journal-title":"Front Immunol"},{"issue":"8","key":"35_CR26","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1016\/j.jid.2020.11.035","volume":"141","author":"W-T Liao","year":"2021","unstructured":"Liao W-T, Hung C-H, Liang S-S, Yu S, Lu J-H, Lee C-H, Chai C-Y, Yu H-S (2021) Anti-inflammatory effects induced by near-infrared light irradiation through M2 macrophage polarization. J Invest Dermatol 141(8):2056\u20132066.e10. https:\/\/doi.org\/10.1016\/j.jid.2020.11.035","journal-title":"J Invest Dermatol"},{"issue":"4","key":"35_CR27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00418-018-1643-3","volume":"149","author":"H Liu","year":"2018","unstructured":"Liu H, Li D, Zhang Y, Li M (2018) Inflammation, mesenchymal stem cells and bone regeneration. Histochem Cell Biol 149(4):393\u2013404. https:\/\/doi.org\/10.1007\/s00418-018-1643-3","journal-title":"Histochem Cell Biol"},{"key":"35_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119833","volume":"239","author":"OR Mahon","year":"2020","unstructured":"Mahon OR, Browe DC, Gonzalez-Fernandez T, Pitacco P, Whelan IT, Von Euw S, Hobbs C, Nicolosi V, Cunningham KT, Mills KHG, Kelly DJ, Dunne A (2020) Nanoparticle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner. Biomaterials 239:119833. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.119833","journal-title":"Biomaterials"},{"issue":"4","key":"35_CR29","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1002\/jcp.26042","volume":"233","author":"M Majidinia","year":"2018","unstructured":"Majidinia M, Sadeghpour A, Yousefi B (2018) The roles of signaling pathways in bone repair and regeneration. J Cell Physiol 233(4):2937\u20132948. https:\/\/doi.org\/10.1002\/jcp.26042","journal-title":"J Cell Physiol"},{"key":"35_CR30","doi-asserted-by":"publisher","unstructured":"Marquez-Lara A, Hutchinson ID, Nu\u00f1ez F, Smith TL, Miller AN (2016) Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality. JBJS Rev 4(3). https:\/\/doi.org\/10.2106\/JBJS.RVW.O.00055","DOI":"10.2106\/JBJS.RVW.O.00055"},{"key":"35_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155828","volume":"153","author":"K Matsushima","year":"2022","unstructured":"Matsushima K, Yang D, Oppenheim JJ (2022) Interleukin-8: an evolving chemokine. Cytokine 153:155828. https:\/\/doi.org\/10.1016\/j.cyto.2022.155828","journal-title":"Cytokine"},{"issue":"3","key":"35_CR32","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/cells13030208","volume":"13","author":"AC Mihaila","year":"2024","unstructured":"Mihaila AC, Ciortan L, Tucureanu MM, Simionescu M, Butoi E (2024) Anti-inflammatory neutrophils reprogram macrophages toward a pro-healing phenotype with increased efferocytosis capacity. Cells 13(3):208. https:\/\/doi.org\/10.3390\/cells13030208","journal-title":"Cells"},{"issue":"4","key":"35_CR33","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s13577-022-00711-7","volume":"35","author":"Q Mo","year":"2022","unstructured":"Mo Q, Zhang W, Zhu A, Backman LJ, Chen J (2022) Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1\u03b2 and TNF-\u03b1: current conclusions and controversies. Hum Cell 35(4):957\u2013971. https:\/\/doi.org\/10.1007\/s13577-022-00711-7","journal-title":"Hum Cell"},{"issue":"3","key":"35_CR34","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s13770-023-00525-0","volume":"20","author":"S Moon","year":"2023","unstructured":"Moon S, Hong J, Go S, Kim B-S (2023) Immunomodulation for tissue repair and regeneration. Tissue Eng Regen Med 20(3):389\u2013409. https:\/\/doi.org\/10.1007\/s13770-023-00525-0","journal-title":"Tissue Eng Regen Med"},{"issue":"suppl 3","key":"35_CR35","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2106\/JBJS.F.00454","volume":"88","author":"M Murnaghan","year":"2006","unstructured":"Murnaghan M, Li G, Marsh DR (2006) Nonsteroidal anti-inflammatory drug-induced fracture nonunion: an inhibition of angiogenesis? J Bone Joint Surg Am 88(suppl 3):140\u2013147. https:\/\/doi.org\/10.2106\/JBJS.F.00454","journal-title":"J Bone Joint Surg Am"},{"issue":"9","key":"35_CR36","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3390\/nu8090530","volume":"8","author":"S Najeeb","year":"2016","unstructured":"Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Almas K (2016) The role of nutrition in periodontal health: an update. Nutrients 8(9):530. https:\/\/doi.org\/10.3390\/nu8090530","journal-title":"Nutrients"},{"issue":"1","key":"35_CR37","doi-asserted-by":"publisher","first-page":"10928","DOI":"10.1038\/ncomms10928","volume":"7","author":"T Ono","year":"2016","unstructured":"Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H (2016) IL-17-producing \u03b3\u03b4 T cells enhance bone regeneration. Nat Commun 7(1):10928. https:\/\/doi.org\/10.1038\/ncomms10928","journal-title":"Nat Commun"},{"issue":"1","key":"35_CR38","doi-asserted-by":"publisher","first-page":"8248","DOI":"10.1038\/s41598-019-44498-4","volume":"9","author":"D Park","year":"2019","unstructured":"Park D, Choi EJ, Weon K-Y, Lee W, Lee SH, Choi J-S, Park GH, Lee B, Byun MR, Baek K, Choi JW (2019) Non-invasive photodynamic therapy against -periodontitis-causing bacteria. Sci Rep 9(1):8248. https:\/\/doi.org\/10.1038\/s41598-019-44498-4","journal-title":"Sci Rep"},{"issue":"2","key":"35_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1089\/pho.2017.4344","volume":"36","author":"FJ Peat","year":"2018","unstructured":"Peat FJ, Colbath AC, Bentsen LM, Goodrich LR, King MR (2018) In vitro effects of high-intensity laser photobiomodulation on equine bone marrow-derived mesenchymal stem cell viability and cytokine expression. Photomed Laser Surg 36(2):83\u201391. https:\/\/doi.org\/10.1089\/pho.2017.4344","journal-title":"Photomed Laser Surg"},{"issue":"1","key":"35_CR40","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41368-022-00207-y","volume":"14","author":"J Peng","year":"2022","unstructured":"Peng J, Zhao J, Tang Q, Wang J, Song W, Lu X, Huang X, Chen G, Zheng W, Zhang L, Han Y, Yan C, Wan Q, Chen L (2022) Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1. Int J Oral Sci 14(1):53. https:\/\/doi.org\/10.1038\/s41368-022-00207-y","journal-title":"Int J Oral Sci"},{"issue":"3","key":"35_CR41","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1021\/acsmedchemlett.6b00476","volume":"8","author":"N Pereira","year":"2017","unstructured":"Pereira N, Laranjo M, Casalta-Lopes J, Serra AC, Pi\u00f1eiro M, Pina J, Seixas de Melo JS, Senge MO, Botelho MF, Martelo L, Burrows HD, Pinho e Melo TMVDVD (2017) Platinum(II) ring-fused Chlorins as near-infrared emitting oxygen sensors and photodynamic agents. ACS Med Chem Lett 8(3):310\u2013315. https:\/\/doi.org\/10.1021\/acsmedchemlett.6b00476","journal-title":"ACS Med Chem Lett"},{"issue":"6","key":"35_CR42","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1111\/iej.13057","volume":"52","author":"G Plotino","year":"2019","unstructured":"Plotino G, Grande NM, Mercade M (2019) Photodynamic therapy in endodontics. Int Endod J 52(6):760\u2013774. https:\/\/doi.org\/10.1111\/iej.13057","journal-title":"Int Endod J"},{"issue":"2","key":"35_CR43","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/jphp.12506","volume":"68","author":"B Poon","year":"2016","unstructured":"Poon B, Kha T, Tran S, Dass CR (2016) Bone morphogenetic protein-2 and bone therapy: successes and pitfalls. J Pharm Pharmacol 68(2):139\u2013147. https:\/\/doi.org\/10.1111\/jphp.12506","journal-title":"J Pharm Pharmacol"},{"issue":"4","key":"35_CR44","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/s41577-020-00452-4","volume":"21","author":"JC Ribot","year":"2021","unstructured":"Ribot JC, Lopes N, Silva-Santos B (2021) \u0393\u03b4 T cells in tissue physiology and surveillance. Nat Rev Immunol 21(4):221\u2013232. https:\/\/doi.org\/10.1038\/s41577-020-00452-4","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"35_CR45","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/s41419-020-03059-8","volume":"11","author":"J-Y Ru","year":"2020","unstructured":"Ru J-Y, Wang Y-F (2020) Osteocyte apoptosis: the roles and key molecular mechanisms in resorption-related bone diseases. Cell Death Dis 11(10):846. https:\/\/doi.org\/10.1038\/s41419-020-03059-8","journal-title":"Cell Death Dis"},{"key":"35_CR46","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.3389\/fimmu.2019.01954","volume":"10","author":"C Schlundt","year":"2019","unstructured":"Schlundt C, Reinke S, Geissler S, Bucher CH, Giannini C, M\u00e4rdian S, Dahne M, Kleber C, Samans B, Baron U, Duda GN, Volk H-D, Schmidt-Bleek K (2019) Individual effector\/regulator T cell ratios impact bone regeneration. Front Immunol 10:1954. https:\/\/doi.org\/10.3389\/fimmu.2019.01954","journal-title":"Front Immunol"},{"key":"35_CR47","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.actbio.2021.04.052","volume":"133","author":"C Schlundt","year":"2021","unstructured":"Schlundt C, Fischer H, Bucher CH, Rendenbach C, Duda GN, Schmidt-Bleek K (2021) The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time. Acta Biomater 133:46\u201357. https:\/\/doi.org\/10.1016\/j.actbio.2021.04.052","journal-title":"Acta Biomater"},{"issue":"4","key":"35_CR48","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s11914-018-0459-3","volume":"16","author":"G Shapiro","year":"2018","unstructured":"Shapiro G, Lieber R, Gazit D, Pelled G (2018) Recent advances and future of gene therapy for bone regeneration. Curr Osteoporos Rep 16(4):504\u2013511. https:\/\/doi.org\/10.1007\/s11914-018-0459-3","journal-title":"Curr Osteoporos Rep"},{"issue":"3","key":"35_CR49","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/term.3009","volume":"14","author":"A Shavandi","year":"2020","unstructured":"Shavandi A, Saeedi P, G\u00e9rard P, Jalalvandi E, Cannella D, Bekhit AE-D (2020) The role of microbiota in tissue repair and regeneration. J Tissue Eng Regen Med 14(3):539\u2013555. https:\/\/doi.org\/10.1002\/term.3009","journal-title":"J Tissue Eng Regen Med"},{"issue":"18","key":"35_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304585","volume":"13","author":"W Shi","year":"2024","unstructured":"Shi W, Feng Y, Tang J, Xu Y, Wang W, Zhang L, Jiang X, Ding Z, Xi K, Chen L, Gu Y (2024) A genetically engineered \u201creinforced concrete\u201d scaffold regulates the N2 neutrophil innate immune cascade to repair bone defects. Adv Healthc Mater 13(18):e2304585. https:\/\/doi.org\/10.1002\/adhm.202304585","journal-title":"Adv Healthc Mater"},{"issue":"6","key":"35_CR51","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1359\/jbmr.2002.17.6.963","volume":"17","author":"AM Simon","year":"2002","unstructured":"Simon AM, Manigrasso MB, O\u2019Connor JP (2002) Cyclooxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 17(6):963\u2013976. https:\/\/doi.org\/10.1359\/jbmr.2002.17.6.963","journal-title":"J Bone Miner Res"},{"issue":"2","key":"35_CR52","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/dj8020043","volume":"8","author":"A St\u00e1jer","year":"2020","unstructured":"St\u00e1jer A, Kaj\u00e1ri S, Gajd\u00e1cs M, Musah-Eroje A, Bar\u00e1th Z (2020) Utility of photodynamic therapy in dentistry: current concepts. Dent J 8(2):43. https:\/\/doi.org\/10.3390\/dj8020043","journal-title":"Dent J"},{"key":"35_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2024.117962","volume":"114","author":"N Suresh","year":"2024","unstructured":"Suresh N, Joseph B, Sathyan P, Sweety VK, Waltimo T, Anil S (2024) Photodynamic therapy: an emerging therapeutic modality in dentistry. Bioorg Med Chem 114:117962. https:\/\/doi.org\/10.1016\/j.bmc.2024.117962","journal-title":"Bioorg Med Chem"},{"issue":"9","key":"35_CR54","doi-asserted-by":"publisher","first-page":"5222","DOI":"10.1021\/acsbiomaterials.3c00609","volume":"9","author":"A Szwed-Georgiou","year":"2023","unstructured":"Szwed-Georgiou A, P\u0142oci\u0144ski P, Kupikowska-Stobba B, Urbaniak MM, Rusek-Wala P, Szustakiewicz K, Piszko P, Krupa A, Biernat M, Gazi\u0144ska M, Kasprzak M, Nawrotek K, Mira NP, Rudnicka K (2023) Bioactive materials for bone regeneration: biomolecules and delivery systems. ACS Biomater Sci Eng 9(9):5222\u20135254. https:\/\/doi.org\/10.1021\/acsbiomaterials.3c00609","journal-title":"ACS Biomater Sci Eng"},{"key":"35_CR55","doi-asserted-by":"publisher","unstructured":"Tani A, Chellini F, Giannelli M, Nosi D, Zecchi-Orlandini S, Sassoli C (2018) Red (635 nm), near-infrared (808 nm) and violet-blue (405 nm) photobiomodulation potentiality on human osteoblasts and mesenchymal stromal cells: a morphological and molecular in vitro study. Int J Mol Sci 19(7). https:\/\/doi.org\/10.3390\/ijms19071946","DOI":"10.3390\/ijms19071946"},{"issue":"4","key":"35_CR56","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3390\/biomimetics9040230","volume":"9","author":"MAH Tanvir","year":"2024","unstructured":"Tanvir MAH, Khaleque MA, Kim G-H, Yoo W-Y, Kim Y-Y (2024) The role of bioceramics for bone regeneration: history, mechanisms, and future perspectives. Biomimetics (Basel) 9(4):230. https:\/\/doi.org\/10.3390\/biomimetics9040230","journal-title":"Biomimetics (Basel)"},{"key":"35_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.12.008","volume":"193","author":"L Tong","year":"2019","unstructured":"Tong L, Liao Q, Zhao Y, Huang H, Gao A, Zhang W, Gao X, Wei W, Guan M, Chu PK, Wang H (2019) Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant. Biomaterials 193:1\u201311. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.12.008","journal-title":"Biomaterials"},{"issue":"13","key":"35_CR58","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.3390\/jcm12134385","volume":"12","author":"B Torrecillas-Baena","year":"2023","unstructured":"Torrecillas-Baena B, Pulido-Escribano V, Dorado G, G\u00e1lvez-Moreno M\u00c1, Camacho-Cardenosa M, Casado-D\u00edaz A (2023) Clinical potential of mesenchymal stem cell-derived exosomes in bone regeneration. J Clin Med 12(13):4385. https:\/\/doi.org\/10.3390\/jcm12134385","journal-title":"J Clin Med"},{"key":"35_CR59","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jphotobiol.2017.04.014","volume":"170","author":"S-R Tsai","year":"2017","unstructured":"Tsai S-R, Hamblin MR (2017) Biological effects and medical applications of infrared radiation. J Photochem Photobiol B 170:197\u2013207. https:\/\/doi.org\/10.1016\/j.jphotobiol.2017.04.014","journal-title":"J Photochem Photobiol B"},{"issue":"12","key":"35_CR60","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00264-013-2059-2","volume":"37","author":"X Wang","year":"2013","unstructured":"Wang X, Wang Y, Gou W, Lu Q, Peng J, Lu S (2013) Role of mesenchymal stem cells in bone regeneration and fracture repair: a review. Int Orthop 37(12):2491\u20132498. https:\/\/doi.org\/10.1007\/s00264-013-2059-2","journal-title":"Int Orthop"},{"key":"35_CR61","doi-asserted-by":"publisher","first-page":"33719","DOI":"10.1038\/srep33719","volume":"6","author":"Y Wang","year":"2016","unstructured":"Wang Y, Huang Y-Y, Wang Y, Lyu P, Hamblin MR (2016) Photobiomodulation (blue and green light) encourages osteoblastic-differentiation of human adipose-derived stem cells: role of intracellular calcium and light-gated ion channels. Sci Rep 6:33719. https:\/\/doi.org\/10.1038\/srep33719","journal-title":"Sci Rep"},{"issue":"1","key":"35_CR62","doi-asserted-by":"publisher","first-page":"7781","DOI":"10.1038\/s41598-017-07525-w","volume":"7","author":"Y Wang","year":"2017","unstructured":"Wang Y, Huang Y-Y, Wang Y, Lyu P, Hamblin MR (2017) Red (660\u2009nm) or near-infrared (810\u2009nm) photobiomodulation stimulates, while blue (415\u2009nm), green (540\u2009nm) light inhibits proliferation in human adipose-derived stem cells. Sci Rep 7(1):7781. https:\/\/doi.org\/10.1038\/s41598-017-07525-w","journal-title":"Sci Rep"},{"key":"35_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101401","volume":"43","author":"L Wang","year":"2022","unstructured":"Wang L, Hu P, Jiang H, Zhao J, Tang J, Jiang D, Wang J, Shi J, Jia W (2022a) Mild hyperthermia-mediated osteogenesis and angiogenesis play a critical role in magnetothermal composite-induced bone regeneration. Nano Today 43:101401. https:\/\/doi.org\/10.1016\/j.nantod.2022.101401","journal-title":"Nano Today"},{"key":"35_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110621","volume":"217","author":"S Wang","year":"2022","unstructured":"Wang S, Wang F, Zhao X, Yang F, Xu Y, Yan F, Xia D, Liu Y (2022b) The effect of near-infrared light-assisted photothermal therapy combined with polymer materials on promoting bone regeneration: a systematic review. Mater Des 217:110621. https:\/\/doi.org\/10.1016\/j.matdes.2022.110621","journal-title":"Mater Des"},{"issue":"1","key":"35_CR65","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12951-023-02124-6","volume":"21","author":"W Wang","year":"2023","unstructured":"Wang W, Zhang G, Wang Y, Ran J, Chen L, Wei Z, Zou H, Cai Y, Han W (2023) An injectable and thermosensitive hydrogel with nano-aided NIR-II phototherapeutic and chemical effects for periodontal antibacteria and bone regeneration. J Nanobiotechnol 21(1):367. https:\/\/doi.org\/10.1186\/s12951-023-02124-6","journal-title":"J Nanobiotechnol"},{"key":"35_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215350","volume":"495","author":"M Warszy\u0144ska","year":"2023","unstructured":"Warszy\u0144ska M, Repetowski P, D\u0105browski JM (2023) Photodynamic therapy combined with immunotherapy: recent advances and future research directions. Coord Chem Rev 495:215350. https:\/\/doi.org\/10.1016\/j.ccr.2023.215350","journal-title":"Coord Chem Rev"},{"issue":"4","key":"35_CR67","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3390\/nano13040692","volume":"13","author":"J Wen","year":"2023","unstructured":"Wen J, Cai D, Gao W, He R, Li Y, Zhou Y, Klein T, Xiao L, Xiao Y (2023) Osteoimmunomodulatory nanoparticles for bone regeneration. Nanomaterials (Basel) 13(4):692. https:\/\/doi.org\/10.3390\/nano13040692","journal-title":"Nanomaterials (Basel)"},{"issue":"3","key":"35_CR68","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/BRS.0b013e3181af8360","volume":"35","author":"E Won","year":"2010","unstructured":"Won E, Akens MK, Hardisty MR, Burch S, Bisland SK, Yee AJM, Wilson BC, Whyne CM (2010) Effects of photodynamic therapy on the structural integrity of vertebral bone. Spine 35(3):272\u2013277. https:\/\/doi.org\/10.1097\/BRS.0b013e3181af8360","journal-title":"Spine"},{"key":"35_CR69","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3389\/fbioe.2020.00805","volume":"8","author":"L Xie","year":"2020","unstructured":"Xie L, Cai L, Wang F, Zhang L, Wang Q, Guo X (2020) Systematic review of prognostic gene signature in gastric cancer patients. Front Bioeng Biotechnol 8:805. https:\/\/doi.org\/10.3389\/fbioe.2020.00805","journal-title":"Front Bioeng Biotechnol"},{"key":"35_CR70","doi-asserted-by":"publisher","unstructured":"Xu J, Yu L, Liu F, Wan L, Deng Z (2023) The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review. Front Immunol:14. https:\/\/doi.org\/10.3389\/fimmu.2023.1222129","DOI":"10.3389\/fimmu.2023.1222129"},{"issue":"29","key":"35_CR71","doi-asserted-by":"publisher","first-page":"37581","DOI":"10.1021\/acsami.4c06346","volume":"16","author":"P Xue","year":"2024","unstructured":"Xue P, Xi H, Tan X, Chen H, Peng C, Sun G, Ye Y, Jiang X, Liu X, Du B (2024) Near-infrared responsive properties of bone repair scaffolds facilitated by specific osteoinductive photothermal converters for highly efficient bone repair. ACS Appl Mater Interfaces 16(29):37581\u201337595. https:\/\/doi.org\/10.1021\/acsami.4c06346","journal-title":"ACS Appl Mater Interfaces"},{"issue":"16","key":"35_CR72","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.7150\/ijms.61080","volume":"18","author":"N Yang","year":"2021","unstructured":"Yang N, Liu Y (2021) The role of the immune microenvironment in bone regeneration. Int J Med Sci 18(16):3697\u20133707. https:\/\/doi.org\/10.7150\/ijms.61080","journal-title":"Int J Med Sci"},{"key":"35_CR73","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.2147\/IJN.S458295","volume":"19","author":"J Yang","year":"2024","unstructured":"Yang J, Xie Y, Xia Z, Ji S, Yang X, Yue D, Liu Y, Yang R, Fan Y (2024) HucMSC-exo induced N2 polarization of neutrophils: implications for angiogenesis and tissue restoration in wound healing. Int J Nanomedicine 19:3555\u20133575. https:\/\/doi.org\/10.2147\/IJN.S458295","journal-title":"Int J Nanomedicine"},{"issue":"10","key":"35_CR74","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1089\/scd.2009.0393","volume":"19","author":"DS Yoon","year":"2010","unstructured":"Yoon DS, Yoo JH, Kim YH, Paik S, Han CD, Lee JW (2010) The effects of COX-2 inhibitor during osteogenic differentiation of bone marrow-derived human mesenchymal stem cells. Stem Cells Dev 19(10):1523\u20131533. https:\/\/doi.org\/10.1089\/scd.2009.0393","journal-title":"Stem Cells Dev"},{"key":"35_CR75","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14053","volume":"10","author":"Y Yu","year":"2022","unstructured":"Yu Y, Yue Z, Xu M, Zhang M, Shen X, Ma Z, Li J, Xie X (2022) Macrophages play a key role in tissue repair and regeneration. PeerJ 10:e14053. https:\/\/doi.org\/10.7717\/peerj.14053","journal-title":"PeerJ"}],"container-title":["Advances in Experimental Medicine and Biology","Oral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-03176-1_35","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:29:35Z","timestamp":1771360175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-03176-1_35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"ISBN":["9783032031754","9783032031761"],"references-count":75,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-03176-1_35","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"13 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}