{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:04:33Z","timestamp":1744157073191,"version":"3.40.3"},"publisher-location":"Cham","reference-count":144,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319071442"},{"type":"electronic","value":"9783319071459"}],"license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-3-319-07145-9_16","type":"book-chapter","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T14:46:27Z","timestamp":1417531587000},"page":"323-366","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Meroterpenoids from Marine Microorganisms: Potential Scaffolds for New Chemotherapy Leads"],"prefix":"10.1007","author":[{"given":"Nelson G. M.","family":"Gomes","sequence":"first","affiliation":[]},{"given":"Suradet","family":"Buttachon","sequence":"additional","affiliation":[]},{"given":"Anake","family":"Kijjoa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"key":"16_CR1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1021\/np9904004","volume":"63","author":"SS Afiyatullov","year":"2000","unstructured":"Cragg GM, Newman DJ (2013) Natural products: a continuing source of novel drug leads. Biochim Biophys Acta 1830:3670\u20133695","journal-title":"J Nat Prod"},{"key":"16_CR2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1021\/np010503y","volume":"65","author":"SS Afiyatullov","year":"2002","unstructured":"Petit K, Biard J-F (2013) Marine natural products and related compounds as anticancer agents: an overview of their clinical status. Anticancer Agents Med Chem 13(4):603\u2013631","journal-title":"J Nat Prod"},{"key":"16_CR3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/np0305324","volume":"67","author":"SS Afiyatullov","year":"2004","unstructured":"Bergmann W, Feeney RJ (1951) Contributions to the study of marine products. XXXII. The nucleosides of sponges I. J Org Chem 16(6):981\u2013987","journal-title":"J Nat Prod"},{"key":"16_CR4","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1021\/np0580863","volume":"68","author":"SS Afiyatullov","year":"2005","unstructured":"Cuevas C, P\u00e9rez M, Mart\u00edn MJ et al (2000) Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B. Org Lett 2(16):2545\u20132548","journal-title":"J Nat Prod"},{"issue":"10","key":"16_CR5","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1080\/14786410500277720","volume":"20","author":"SS Afiyatullov","year":"2006","unstructured":"Rinehart KL, Holt TG, Fregeau NL et\u00a0al (1990) Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J Org Chem 55(15):4512\u20134515","journal-title":"Nat Prod Res"},{"key":"16_CR6","doi-asserted-by":"crossref","first-page":"8827","DOI":"10.1002\/chem.201103278","volume":"18","author":"C Almeida","year":"2012","unstructured":"Rinehart KL, Holt TG, Fregeau NL et\u00a0al (1991) Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata [Erratum to document cited in CA113(9):75189d]. J Org Chem 56(4):1676","journal-title":"Chem Eur J"},{"key":"16_CR7","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1021\/jm030090t","volume":"46","author":"T Amagata","year":"2003","unstructured":"Wright AE, Forleo DA, Gunawardana GP et\u00a0al (1990) Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata. J Org Chem 55(15):4508\u20134512","journal-title":"J Med Chem"},{"issue":"24","key":"16_CR8","doi-asserted-by":"crossref","first-page":"15882","DOI":"10.1016\/S0021-9258(18)98491-7","volume":"266","author":"RL Bai","year":"1991","unstructured":"Bai RL, Paull KD, Herald CL et\u00a0al (1991) Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem 266(24):15882\u201315889","journal-title":"J Biol Chem"},{"issue":"15s","key":"16_CR9","doi-asserted-by":"crossref","first-page":"8500","DOI":"10.1200\/jco.2009.27.15_suppl.8500","volume":"27","author":"N Bartlett","year":"2009","unstructured":"Hirata Y, Uemura D (1986) Halichondrins\u2014antitumor polyether macrolides from a marine sponge. Pure Appl Chem 58(5):701\u2013710","journal-title":"J Clin Oncol"},{"key":"16_CR10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/ja00521a004","volume":"102","author":"N Bellavita","year":"1980","unstructured":"Towle MJ, Salvato KA, Wels BF et\u00a0al (2011) Eribulin mesylate induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res 71(2):496\u2013505","journal-title":"J Am Chem Soc"},{"key":"16_CR11","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0040-4020(97)10396-9","volume":"54","author":"GN Belofsky","year":"1998","unstructured":"Bartlett N, Forero-Torres A, Rosenblatt J et\u00a0al (2009) Complete remissions with weekly dosing of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in a phase I dose-escalation study in patients with relapsed or refractory Hodgkin lymphoma (HL) or systemic anaplastic large cell lymphoma (sALCL). J Clin Oncol 27(15s):8500","journal-title":"Tetrahedron"},{"issue":"6","key":"16_CR12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1021\/jo01146a023","volume":"16","author":"W Bergmann","year":"1951","unstructured":"Pettit GR, Kamano Y, Herald CL et\u00a0al (1987) The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10. J Am Chem Soc 109(22):6883\u20136885","journal-title":"J Org Chem"},{"issue":"12","key":"16_CR13","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1021\/ja201088k","volume":"133","author":"P Bernhardt","year":"2011","unstructured":"Bhatnagar I, Kim S-K (2010) Immense essence of excellence: marine microbial bioactive compounds. Mar Drugs 8:2673\u20132701","journal-title":"J Am Chem Soc"},{"key":"16_CR14","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1016\/j.bmc.2011.06.083","volume":"19","author":"F Berru\u00e9","year":"2011","unstructured":"Gerwick WH, Fenner AM (2013) Drug discovery from marine microbes. Microb Ecol 65:800\u2013806","journal-title":"Bioorg Med Chem"},{"key":"16_CR15","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.bcp.2010.07.018","volume":"80","author":"T Bertomeu","year":"2010","unstructured":"Newman DJ, Hill RT (2006) New drugs from marine microbes: the tide is turning. J Ind Microbiol Biotechnol 33:539\u2013544","journal-title":"Biochem Pharmacol"},{"key":"16_CR16","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3390\/md8102673","volume":"8","author":"I Bhatnagar","year":"2010","unstructured":"Hayashi Y, Nicholson B, Tanaka K et\u00a0al (2005) Effect of the phenyl ring modification on the antitumor activity of anti-microtubule agent dehydrophenylahistin. Pept Sci 2004 (41th Japanese Peptide Symposium) 405\u2013406","journal-title":"Mar Drugs"},{"issue":"5","key":"16_CR17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/CAD.0b013e328337f373","volume":"21","author":"N Boufaied","year":"2010","unstructured":"Kanoh K, Kohno S, Asari T et\u00a0al (1997) (-)-Phenylahistin: a new mammalian cell cycle inhibitor produced by Aspergillus ustus. Bioorg Med Chem Lett 7(22):2847\u20132852","journal-title":"Anticancer Drugs"},{"key":"16_CR18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1039\/b301926h","volume":"21","author":"TS Bugni","year":"2004","unstructured":"Spear MA, LoRusso P, Tolcher AW et\u00a0al (2007) A phase 1 dynamic accelerated titration dose escalation study of the vascular disrupting agent NPI-2358. J Clin Oncol 25(18s):14097","journal-title":"Nat Prod Rep"},{"key":"16_CR19","first-page":"1354","volume":"99","author":"N Cagnoli-Bellavita","year":"1969","unstructured":"Yamazaki Y, Sumikura M, Hidaka K et\u00a0al (2010) Anti-microtubule \u2018plinabulin\u2019 chemical probe KPU-244-B3 labeled both \u03b1- and \u03b2-tubulin. Bioorg Med Chem 18(9):3169\u20133174","journal-title":"Gazz Chim Ital"},{"key":"16_CR20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1432-1033.1970.tb01015.x","volume":"15","author":"N Cagnoli-Bellavita","year":"1970","unstructured":"Feling RH, Buchanan GO, Mincer TJ et\u00a0al (2003) Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed Engl 42(3):355\u2013357","journal-title":"Eur J Biochem"},{"key":"16_CR21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-2187-5-18","volume":"5","author":"PM Campbell","year":"2010","unstructured":"Hamlin PA, Aghajanian C, Younes A et\u00a0al (2009) First-in-human phase 1 study of the novel structure proteasome inhibitor NPI-0052. J Clin Oncol 27(15s):3516","journal-title":"J Mol Signal"},{"key":"16_CR22","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1021\/np040042r","volume":"67","author":"RD Charan","year":"2004","unstructured":"Potts BC, Albitar MX, Anderson KC et\u00a0al (2011) Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets 11(3):254\u2013284","journal-title":"J Nat Prod"},{"issue":"10","key":"16_CR23","first-page":"1275","volume":"45","author":"L Chen","year":"2010","unstructured":"Haefner B (2003) Drugs from the deep: marine natural products as drug candidates. Drug Discov Today 8(12):536\u2013544","journal-title":"Acta Pharm Sin"},{"issue":"12","key":"16_CR24","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1021\/ol060630r","volume":"8","author":"JY Cho","year":"2006","unstructured":"Luesch H, Moore RE, Paul VJ et\u00a0al (2001) Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. J Nat Prod 64(7):907\u2013910","journal-title":"Org Lett"},{"key":"16_CR25","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1016\/j.bmc.2011.05.045","volume":"19","author":"E Cohen","year":"2011","unstructured":"Willimanson RT, Chapin EL, Carr AW et\u00a0al (2000) New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures. Org Lett 2(3):289\u2013292","journal-title":"Bioorg Med Chem"},{"key":"16_CR26","first-page":"102","volume":"4","author":"JW Cornforth","year":"1968","unstructured":"Rath CM, Janto B, Earl J et\u00a0al (2011) Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol 6:1244\u20131256","journal-title":"Chem Br"},{"key":"16_CR27","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","volume":"1830","author":"GM Cragg","year":"2013","unstructured":"Geris R, Simpson TJ (2009) Meroterpenoids produced by fungi. Nat Prod Rep 26:1063\u20131094","journal-title":"Biochim Biophys Acta"},{"key":"16_CR28","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1021\/np0102713","volume":"64","author":"M Cueto","year":"2001","unstructured":"Shiomi K, Tomoda H, Otoguro K et\u00a0al (1999) Meroterpenoids with various biological activities produced by fungi. Pure Appl Chem 71:1059\u20131064","journal-title":"J Nat Prod"},{"key":"16_CR29","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.phytochem.2006.01.008","volume":"67","author":"M Cueto","year":"2006","unstructured":"Cornforth JW (1968) Terpene biosynthesis. Chem Br 4:102\u2013106","journal-title":"Phytochemistry"},{"issue":"16","key":"16_CR30","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/ol0062502","volume":"2","author":"C Cuevas","year":"2000","unstructured":"Simpson TJ (1987) Applications of multinuclear NMR to structural and biosynthetic studies of polyketide microbial metabolites. Chem Soc Rev 16:123\u2013160","journal-title":"Org Lett"},{"issue":"11","key":"16_CR31","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.7164\/antibiotics.48.1382","volume":"48","author":"C-B Cui","year":"1995","unstructured":"De Rosa S, De Giulio A, Iodice C (1994) Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays. J Nat Prod 57(12):1711\u20131716","journal-title":"J Antibiot"},{"key":"16_CR32","doi-asserted-by":"crossref","unstructured":"Itoh T, Tokunaga K, Radhakrishnan EK et\u00a0al (2012) Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid. Chembiochem 13(8):1132\u20131135","DOI":"10.1002\/cbic.201200124"},{"key":"16_CR33","doi-asserted-by":"crossref","unstructured":"Saleh O, Haagen Y, Seeger K et\u00a0al (2009) Prenyl transfer to aromatic substrates in the biosynthesis of aminocoumarins, meroterpenoids and phenazines: the ABBA prenyltransferase family. Phytochemistry 70:1728\u20131738","DOI":"10.1016\/j.phytochem.2009.05.009"},{"key":"16_CR34","doi-asserted-by":"crossref","unstructured":"Sunassee SN, Davies-Coleman MT (2012) Cytotoxic and antioxidant marine prenylated quinones and hydroquinones. Nat Prod Rep 29:513\u2013535","DOI":"10.1039\/c2np00086e"},{"issue":"39","key":"16_CR35","doi-asserted-by":"crossref","first-page":"12651","DOI":"10.1016\/0040-4020(96)00737-5","volume":"52","author":"C-B Cui","year":"1996d","unstructured":"Li S-M (2010) Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis. Nat Prod Rep 27:57\u201378","journal-title":"Tetrahedron"},{"issue":"1","key":"16_CR36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0040-4020(96)00978-7","volume":"53","author":"C-B Cui","year":"1997","unstructured":"Berru\u00e9 F, McCulloch MWB, Kerr RG (2011) Marine diterpene glycosides. Bioorg Med Chem 19:6702\u20136719","journal-title":"Tetrahedron"},{"key":"16_CR37","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/np900569t","volume":"73","author":"C-M Cui","year":"2010","unstructured":"Li Y-X, Himaya SWA, Kim S-K (2013) Triterpenoids of marine origin as anti-cancer agents. Molecules 18:7886\u20137909","journal-title":"J Nat Prod"},{"issue":"12","key":"16_CR38","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1021\/np50114a015","volume":"57","author":"S De Rosa","year":"1994","unstructured":"Bugni TS, Ireland CM (2004) Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep 21:143\u2013163","journal-title":"J Nat Prod"},{"issue":"20","key":"16_CR39","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1016\/j.bmcl.2010.09.010","volume":"15","author":"L Ding","year":"2010","unstructured":"Rateb ME, Ebel R (2011) Secondary metabolites of fungi from marine habitats. Nat Prod Rep 28:290\u2013344","journal-title":"Bioorg Med Chem Lett"},{"key":"16_CR40","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1039\/c1ob05283g","volume":"9","author":"L Ding","year":"2011","unstructured":"Fenical W, Jensen PR (2006) Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol 2(12):666\u2013673","journal-title":"Org Biomol Chem"},{"issue":"2","key":"16_CR41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1248\/cpb.57.220","volume":"57","author":"L Du","year":"2009","unstructured":"Gallagher KA, Fenical W, Jensen PR (2010) Hybrid isoprenoid secondary metabolite production in terrestrial and marine Actinomycetes. Curr Opin Biotechnol 21:794\u2013800","journal-title":"Chem Pharm Bull"},{"key":"16_CR42","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.1016\/j.tet.2013.07.078","volume":"69","author":"A Eamvijarn","year":"2013","unstructured":"Lam KS (2006) Discovery of novel metabolites from marine actinomycetes. Curr Opin Microbiol 9:245\u2013251","journal-title":"Tetrahedron"},{"key":"16_CR43","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3390\/md10061266","volume":"10","author":"S-M Fang","year":"2012","unstructured":"Liu H, Edrada-Ebel R, Ebel R et\u00a0al (2009) Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. J Nat Prod 72:1585\u20131588","journal-title":"Mar Drugs"},{"issue":"3","key":"16_CR44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/anie.200390115","volume":"42","author":"RH Feling","year":"2003","unstructured":"Lu Z, Wang Y, Miao C et\u00a0al (2009) Sesquiterpenoids and benzofuranoids from the marine-derived fungus Aspergillus ustus 094102. J Nat Prod 72:1761\u20131767","journal-title":"Angew Chem Int Ed Engl"},{"issue":"12","key":"16_CR45","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nchembio841","volume":"2","author":"W Fenical","year":"2006","unstructured":"Mohamed IE, Gross H, Pontius A et\u00a0al (2009) Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp. Org Lett 11(21):5014\u20135017","journal-title":"Nat Chem Biol"},{"key":"16_CR46","doi-asserted-by":"crossref","unstructured":"Mohamed IE, Kehraus S, Krick A et al (2010) Mode of action of epoxyphomalins A and B and characterization of related metabolites from the marine-derived fungus Paraconiothyrium sp. J Nat Prod 73:2053\u20132056","DOI":"10.1021\/np100310k"},{"issue":"6","key":"16_CR47","doi-asserted-by":"crossref","first-page":"623","DOI":"10.7164\/antibiotics.43.623","volume":"43","author":"DS Fukuda","year":"1990","unstructured":"Lin X, Zhou X, Wang F et\u00a0al (2012) A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample. Mar Drugs 10:106\u2013115","journal-title":"J Antibiot"},{"key":"16_CR48","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.copbio.2010.09.010","volume":"21","author":"KA Gallagher","year":"2010","unstructured":"Fang S-M, Cui C-B, Li C-W et\u00a0al (2012) Purpurogemutantin and purpurogemutantidin, new drimenyl cyclohexenone derivatives produced by a mutant obtained by diethyl sulfate mutagenesis of a marine-derived Penicillium purpurogenum G59. Mar Drugs 10:1266\u20131287","journal-title":"Curr Opin Biotechnol"},{"key":"16_CR49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/hlca.201200596","volume":"96","author":"H Gao","year":"2013","unstructured":"Sassa T, Yoshikoshi H (1983) New terpene-linked cyclohexenone epoxides, macrophorin A, B and C, produced by the fungus caused Macrophoma fruit rot of apple. Agric Biol Chem 47(1):187\u2013189","journal-title":"Helv Chim Acta"},{"issue":"9","key":"16_CR50","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.phytochem.2009.06.016","volume":"70","author":"S Genovese","year":"2009","unstructured":"Fraga BM (2013) Natural sesquiterpenoids. Nat Prod Rep 30:1226\u20131264","journal-title":"Phytochemistry"},{"key":"16_CR51","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1039\/b820413f","volume":"26","author":"R Geris","year":"2009","unstructured":"Chen L, Li D-H, Cai S-X et\u00a0al (2010) A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp. Acta Pharm Sin 45(10):1275\u20131278","journal-title":"Nat Prod Rep"},{"key":"16_CR52","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s00248-012-0169-9","volume":"65","author":"WH Gerwick","year":"2013","unstructured":"Belofsky GN, Jensen PR, Renner MK et\u00a0al (1998) New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor. Tetrahedron 54:1715\u20131724","journal-title":"Microb Ecol"},{"key":"16_CR53","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.phytol.2012.07.010","volume":"5","author":"NM Gomes","year":"2012","unstructured":"Cohen E, Koch L, Thu KM et\u00a0al (2011) Novel terpenoids of the fungus Aspergillus insuetus isolated from the Mediterranean sponge Psammocinia sp. collected along the coast of Israel. Bioorg Med Chem 19:6587\u20136593","journal-title":"Phytochemistry Lett"},{"key":"16_CR54","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00280-007-0544-2","volume":"61","author":"H Gourdeau","year":"2008","unstructured":"Cueto M, MacMillan JB, Jensen PR et\u00a0al (2006) Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus. Phytochemistry 67:1826\u20131831","journal-title":"Cancer Chemother Pharmacol"},{"key":"16_CR55","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/np970539j","volume":"61","author":"MA Graber","year":"1998","unstructured":"Kitano M, Yamada T, Amagata T et\u00a0al (2012) Novel pyridino-\u03b1-pyrone sesquiterpene type pileotin produced by a sea urchin-derived Aspergillus sp. Tetrahedron Lett 53:4192\u20134194","journal-title":"J Nat Prod"},{"issue":"12","key":"16_CR56","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S1359-6446(03)02713-2","volume":"8","author":"B Haefner","year":"2003","unstructured":"Eamvijarn A, Gomes NM, Dethoup T (2013) Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213). Tetrahedron 69:8583\u20138591","journal-title":"Drug Discov Today"},{"issue":"15s","key":"16_CR57","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1200\/jco.2009.27.15_suppl.3516","volume":"27","author":"PA Hamlin","year":"2009","unstructured":"Liu D, Li X-M, Meng L et\u00a0al (2011) Nigerapyrones A-H, \u03b1-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132. J Nat Prod 74:1787\u20131791","journal-title":"J Clin Oncol"},{"key":"16_CR58","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0040-4039(00)00117-9","volume":"41","author":"IH Hardt","year":"2000","unstructured":"Gao H, Zhou L, Li D et\u00a0al (2013) New cytotoxic metabolites from the marine-derived fungus Penicillium sp. ZLN29. Helv Chim Acta 96:514\u2013519","journal-title":"Tetrahedron Lett"},{"key":"16_CR59","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3390\/md9040680","volume":"9","author":"NM Haste","year":"2011","unstructured":"Li X, Choi HD, Kang JS et\u00a0al (2003) New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. J Nat Prod 66:1499\u20131500","journal-title":"Mar Drugs"},{"key":"16_CR60","doi-asserted-by":"crossref","unstructured":"Son BW, Kim JC, Choi HD (2002) A radical scavenging farnesylhydroquinone from a marine-derived fungus Penicillium sp. Arch Pharm Res 25(1):77\u201379","DOI":"10.1007\/BF02975266"},{"issue":"5","key":"16_CR61","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1351\/pac198658050701","volume":"58","author":"Y Hirata","year":"1986","unstructured":"Wang J-S, Groopman JD (1999) DNA damage by mycotoxins. Mutat Res 424:167\u2013181","journal-title":"Pure Appl Chem"},{"issue":"24","key":"16_CR62","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1021\/ol202944g","volume":"13","author":"Y Hu","year":"2011","unstructured":"Kralj A, Kehraus S, Krick A et\u00a0al (2006) Arugosins G and H: prenylated polyketides from the marine-derived fungus Emericella nidulans var. acristata. J Nat Prod 69:995\u20131000","journal-title":"Org Lett"},{"key":"16_CR63","doi-asserted-by":"crossref","unstructured":"Parvatkar RR, D\u2019Souza C, Tripathi A et\u00a0al (2009) Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus. Phytochemistry 70:128\u2013132","DOI":"10.1016\/j.phytochem.2008.10.017"},{"issue":"5","key":"16_CR64","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ja.2005.44","volume":"58","author":"Y Igarashi","year":"2005","unstructured":"Du L, Zhu T, Li L et\u00a0al (2009) Cytotoxic sorbicillinoids and bisorbicillinoids from a marine-derived fungus Trichoderma sp. Chem Pharm Bull 57(2):220\u2013223","journal-title":"J Antibiot"},{"issue":"7","key":"16_CR65","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.7164\/antibiotics.42.1196","volume":"42","author":"S Imai","year":"1989","unstructured":"Laurent D, Guella G, Roquebert MF et\u00a0al (2000) Cytotoxins, mycotoxins and drugs from a new deuteromycete, Acremonium neo-caledoniae, from the southwestern lagoon of New Caledonia. Planta Med 66:63\u201366","journal-title":"J Antibiot"},{"issue":"8","key":"16_CR66","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/cbic.201200124","volume":"13","author":"T Itoh","year":"2012","unstructured":"Namikoshi M, Akano K, Meguro S et\u00a0al (2001) A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau. J Nat Prod 64:396\u2013398","journal-title":"Chembiochem"},{"key":"16_CR67","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1016\/j.bmc.2008.02.050","volume":"16","author":"HD Jain","year":"2008","unstructured":"Xu JZ, Takasaki A, Kobayashi H et\u00a0al (2006) Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. J Antibiot 59:451\u2013455","journal-title":"Bioorg Med Chem"},{"issue":"23","key":"16_CR68","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1021\/ol035748b","volume":"5","author":"JA Kalaitzis","year":"2003","unstructured":"Amagata T, Rath C, Rigot JF et\u00a0al (2003) Structures and cytotoxic properties of trichoverroids and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria. J Med Chem 46:4342\u20134350","journal-title":"Org Lett"},{"issue":"22","key":"16_CR69","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1016\/S0960-894X(97)10104-4","volume":"7","author":"K Kanoh","year":"1997","unstructured":"Wei H, Inada H, Hayashi A et\u00a0al (2007) Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived fungus Aspergillus candidus IF10. J Antibiot 60(9):586\u2013590","journal-title":"Bioorg Med Chem Lett"},{"key":"16_CR70","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/anie.200604381","volume":"46","author":"H Kato","year":"2007","unstructured":"Cueto M, Jensen PR, Kauffman C et\u00a0al (2001) Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge. J Nat Prod 64:1444\u20131446","journal-title":"Angew Chem Int Ed"},{"key":"16_CR71","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.1002\/anie.201305232","volume":"52","author":"H Kato","year":"2013","unstructured":"Wang S, Li X-M, Teuscher F et\u00a0al (2006) Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata. J Nat Prod 69:1622\u20131625","journal-title":"Angew Chem Int Ed"},{"issue":"18","key":"16_CR72","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1200\/jco.2007.25.18_suppl.14128","volume":"24","author":"P Kavan","year":"2007","unstructured":"Almeida C, Hemberger Y, Schmitt SM et\u00a0al (2012) Marilines A-C: novel phthalimidines from the sponge-derived fungus Stachylidium sp. Chem Eur J 18:8827\u20138834","journal-title":"J Clin Oncol"},{"issue":"10","key":"16_CR73","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ja.2007.79","volume":"60","author":"K Kimoto","year":"2007","unstructured":"Sun L-L, Shao C-L, Chen J-F et\u00a0al (2012) New bisabolane sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from the sponge Xestospongia testudinaria. Bioorg Med Chem Lett 22:1326\u20131329","journal-title":"J Antibiot"},{"key":"16_CR74","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1016\/j.tetlet.2012.05.144","volume":"53","author":"M Kitano","year":"2012","unstructured":"Kato H, Yoshida T, Tokue T et\u00a0al (2007) Notoamides A-D: Prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp. Angew Chem Int Ed 46:2254\u20132256","journal-title":"Tetrahedron Lett"},{"issue":"8","key":"16_CR75","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7164\/antibiotics.51.801","volume":"51","author":"M Kondoh","year":"1998","unstructured":"Kato H, Yoshida T, Tokue T et\u00a0al (2013) Notoamides A-D: prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp. Angew Chem Int Ed 52:7893\u20137909","journal-title":"J Antibiot"},{"key":"16_CR76","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3390\/md10020451","volume":"10","author":"TP Kondratyuk","year":"2012","unstructured":"Tsukamoto S, Kato H, Samizo M et\u00a0al (2008) Notoamides F\u2212K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp. J Nat Prod 71:2064\u20132067","journal-title":"Mar Drugs"},{"key":"16_CR77","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/np050454f","volume":"69","author":"A Kralj","year":"2006","unstructured":"Tsukamoto S, Kato H, Samizo M et\u00a0al (2013) Correction to notoamides F\u2212K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp. J Nat Prod 76:1233\u20131233","journal-title":"J Nat Prod"},{"key":"16_CR78","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1021\/np1006229","volume":"73","author":"HC Kwon","year":"2010","unstructured":"Cui C-B, Kakeya H, Okada G et\u00a0al (1995) Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus. J Antibiot (Tokyo) 48(11):1382\u20131384","journal-title":"J Nat Prod"},{"key":"16_CR79","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mib.2006.03.004","volume":"9","author":"KS Lam","year":"2006","unstructured":"Cui C-B, Kakeya H, Okada G et\u00a0al (1996a) Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) 49(6):527\u2013533","journal-title":"Curr Opin Microbiol"},{"key":"16_CR80","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1055\/s-2000-11110","volume":"66","author":"D Laurent","year":"2000","unstructured":"Cui C-B, Kakeya H, Osada H (1996b) Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo) 49(6):534\u2013540","journal-title":"Planta Med"},{"key":"16_CR81","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1039\/B909987P","volume":"27","author":"S-M Li","year":"2010","unstructured":"Cui C-B, Kakeya H, Osada H (1996c) Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus. J Antibiot (Tokyo) 49(8):832\u2013835","journal-title":"Nat Prod Rep"},{"key":"16_CR82","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/np030231u","volume":"66","author":"X Li","year":"2003","unstructured":"Cui C-B, Kakeya H, Osada H (1996d) Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2\/M Phase1. Tetrahedron 52(39):12651\u201312666","journal-title":"J Nat Prod"},{"key":"16_CR83","doi-asserted-by":"crossref","first-page":"7886","DOI":"10.3390\/molecules18077886","volume":"18","author":"Y-X Li","year":"2013","unstructured":"Cui C-B, Kakeya H, Osada H (1997) Novel mammalian cell cycle inhibitors, cyclotryprostatins A-D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2\/M phase. Tetrahedron 53(1):59\u201372","journal-title":"Molecules"},{"key":"16_CR84","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/md10010106","volume":"10","author":"X Lin","year":"2012","unstructured":"Jain HD, Zhang C, Zhou S et\u00a0al (2008) Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem 16:4626\u20134651","journal-title":"Mar Drugs"},{"key":"16_CR85","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1021\/np900220r","volume":"72","author":"H Liu","year":"2009","unstructured":"Kondoh M, Usui T, Mayumi T et\u00a0al (1998) Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ. J Antibiot (Tokyo) 51(8):801\u2013804","journal-title":"J Nat Prod"},{"key":"16_CR86","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/np200381u","volume":"74","author":"D Liu","year":"2011","unstructured":"Sanz-Cervera JF, Stocking EM, Usui T et\u00a0al (2000) Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro. Bioorg Med Chem 8:2407\u20132415","journal-title":"J Nat Prod"},{"key":"16_CR87","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/np0204444","volume":"66","author":"JMS L\u00f3pez","year":"2003","unstructured":"Wang F, Fang Y, Zhu T et\u00a0al (2008) Seven new prenylated indole diketopiperazine alkaloids from holothurians-derived fungus Aspergillus fumigatus. Tetrahedron 64:7986\u20137991","journal-title":"J Nat Prod"},{"key":"16_CR88","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1021\/np900268z","volume":"72","author":"Z Lu","year":"2009","unstructured":"Zhang M, Wang W-L, Fang Y-C et\u00a0al (2008) Cytotoxic alkaloids and antibiotic nordammarane triterpenoids from the marine-derived fungus Aspergillus sydowi. J Nat Prod 71:985\u2013989","journal-title":"J Nat Prod"},{"key":"16_CR89","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/np100059m","volume":"73","author":"Z Lu","year":"2010","unstructured":"Gomes NM, Dethoup T, Singburaudom N et\u00a0al (2012) Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum. Phytochemistry Lett 5:718\u2013720","journal-title":"J Nat Prod"},{"issue":"7","key":"16_CR90","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1021\/np010049y","volume":"64","author":"H Luesch","year":"2001","unstructured":"Kimoto K, Aoki T, Shibata Y et\u00a0al (2007) Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death. J Antibiot 60(10):614\u2013621","journal-title":"J Nat Prod"},{"key":"16_CR91","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/np049597c","volume":"68","author":"VR Macherla","year":"2005","unstructured":"Wijesekara I, Li Y-X, Vo T-S et\u00a0al (2013) Induction of apoptosis in human cervical carcinoma HeLa cells by neoechinulin A from marine-derived fungus Microsporum sp. Process Biochem 48:68\u201372","journal-title":"J Nat Prod"},{"key":"16_CR92","doi-asserted-by":"crossref","unstructured":"Cui C-M, Li X-M, Li C-S et\u00a0al (2010) Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod 73:729\u2013733","DOI":"10.1021\/np900569t"},{"issue":"21","key":"16_CR93","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1021\/ol901996g","volume":"11","author":"IE Mohamed","year":"2009","unstructured":"Smetanina OF, Kalinovsky AI, Khudyakova YV et\u00a0al (2007) Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge. J Nat Prod 70:906\u2013909","journal-title":"Org Lett"},{"key":"16_CR94","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1021\/np100310k","volume":"73","author":"IE Mohamed","year":"2010","unstructured":"Afiyatullov SS, Kuznetsova TA, Isakov VV et al (2000) New diterpenic altrosides of the fungus Acremonium striatisporum isolated from a sea cucumber. J Nat Prod 63:848\u2013850","journal-title":"J Nat Prod"},{"key":"16_CR95","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/np070575a","volume":"71","author":"K Motohashi","year":"2008","unstructured":"Afiyatullov SS, Kuznetsova TA, Isakov VV et\u00a0al (2005) New diterpenic altrosides of the fungus Acremonium striatisporum isolated from a sea cucumber. J Nat Prod 68:1308","journal-title":"J Nat Prod"},{"key":"16_CR96","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1021\/np000443g","volume":"64","author":"M Namikoshi","year":"2001","unstructured":"Bellavita N, Bernassau J-M, Ceccherelli P et\u00a0al (1980) Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. 68. An unusual solvent dependence of the carbon-13 nuclear magnetic resonance spectral features of some glycosides as studied by relaxation-time measurements. J Am Chem Soc 102:17\u201320","journal-title":"J Nat Prod"},{"key":"16_CR97","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10295-006-0115-2","volume":"33","author":"DJ Newman","year":"2006","unstructured":"Cagnoli-Bellavita N, Cecherelli P, Ribaldi M et\u00a0al (1969) Virescenoside A and virescenoside B, new altroside metabolites of Oospora virescens. Gazz Chim Ital 99:1354\u20131363","journal-title":"J Ind Microbiol Biotechnol"},{"key":"16_CR98","doi-asserted-by":"crossref","unstructured":"Cagnoli-Bellavita N, Ceccherelli P, Mariani R et al (1970) Structure du virescenoside C, nouveau metabolite de Oospora virescens. Eur J Biochem 15:356\u2013359","DOI":"10.1111\/j.1432-1033.1970.tb01015.x"},{"key":"16_CR99","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.phytochem.2008.10.017","volume":"70","author":"RR Parvatkar","year":"2009","unstructured":"Afiyatullov SS, Kalinovsky AI, Kuznetsova TA et\u00a0al (2002) New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber. J Nat Prod 65:641\u2013644","journal-title":"Phytochemistry"},{"issue":"50","key":"16_CR100","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1016\/0040-4039(93)88010-G","volume":"33","author":"C Pathirana","year":"1992","unstructured":"Afiyatullov SS, Kalinovsky AI, Kuznetsova TA et\u00a0al (2004) New glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber. J Nat Prod 67:1047\u20131051","journal-title":"Tetrahedron Lett"},{"issue":"4","key":"16_CR101","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/chem.200802021","volume":"15","author":"M Pe\u00f1a-L\u00f3pez","year":"2009","unstructured":"Afiyatullov SS, Kalinovsky AI, Pivkin MV et\u00a0al (2006) New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber. Nat Prod Res 20(10):902\u2013908","journal-title":"Chemistry"},{"issue":"4","key":"16_CR102","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/1871520611313040010","volume":"13","author":"K Petit","year":"2013","unstructured":"Lu Z, Zhu H, Fu P et\u00a0al (2010) Cytotoxic polyphenols from the marine-derived fungus Penicillium expansum. J Nat Prod 73:911\u2013914","journal-title":"Anticancer Agents Med Chem"},{"issue":"22","key":"16_CR103","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1021\/ja00256a070","volume":"109","author":"GR Pettit","year":"1987","unstructured":"Cho JY, Kwon HC, Williams PG et\u00a0al (2006) Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). Org Lett 8(12):2471\u20132474","journal-title":"J Am Chem Soc"},{"issue":"3","key":"16_CR104","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/156800911794519716","volume":"11","author":"BC Potts","year":"2011","unstructured":"Pathirana C, Jensen PR, Fenical W (1992) Marinone and debromomarinone: antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacterium. Tetrahedron Lett 33(50):7663\u20137666","journal-title":"Curr Cancer Drug Targets"},{"issue":"10","key":"16_CR105","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1021\/ol200904v","volume":"13","author":"R Raju","year":"2011","unstructured":"Hardt IH, Jensen PR, Fenical W (2000) Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales). Tetrahedron Lett 41:2073\u20132076","journal-title":"Org Lett"},{"key":"16_CR106","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1039\/c0np00061b","volume":"28","author":"ME Rateb","year":"2011","unstructured":"Kalaitzis JA, Hamano Y, Nilsen G et\u00a0al (2003) Biosynthesis and structural revision of neomarinone. Org Lett 5(23):4449\u20134452","journal-title":"Nat Prod Rep"},{"key":"16_CR107","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1021\/cb200244t","volume":"6","author":"CM Rath","year":"2011","unstructured":"Su\u00e1rez RM, Mart\u00ednez MM, Sarandeses LA (2007) Synthetic studies on neomarinone: practical and efficient stereoselective synthesis of the side chain. Tetrahedron Lett 48:6493\u20136495","journal-title":"ACS Chem Biol"},{"key":"16_CR108","doi-asserted-by":"crossref","first-page":"11273","DOI":"10.1021\/ja992482o","volume":"121","author":"MK Renner","year":"1999","unstructured":"Pe\u00f1a-L\u00f3pez M, Mart\u00ednez MM, Sarandeses LA et\u00a0al (2009) Total synthesis of (\u00a0+\u00a0)-neomarinone. Chemistry 15(4):910\u2013916","journal-title":"J Am Chem Soc"},{"issue":"15","key":"16_CR109","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1021\/jo00302a007","volume":"55","author":"KL Rinehart","year":"1990","unstructured":"Shiomi K, Nakamura H, Iinuma H et\u00a0al (1986) Structures of new antibiotics napyradiomycins. J Antibiot (Tokyo) 39(4):494\u2013501","journal-title":"J Org Chem"},{"issue":"4","key":"16_CR110","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1021\/jo00004a063","volume":"56","author":"KL Rinehart","year":"1991","unstructured":"Soria-Mercado IE, Jensen PR, Fenical W et\u00a0al (2004) 3,4a-Dichloro-10a-(3-chloro-6-hydroxy-2,2,6-trimethylcyclohexylmethyl)-6,8-dihydroxy-2,2,7-trimethyl-3,4,4a,10a-tetrahydro-2H-benzo[g]chromene-5,10-dione. Acta Cryst E60:o1627-o1629","journal-title":"J Org Chem"},{"key":"16_CR111","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.phytochem.2009.05.009","volume":"70","author":"O Saleh","year":"2009","unstructured":"Soria-Mercado IE, Prieto-Davo A, Jensen PR et\u00a0al (2005) Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete. J Nat Prod 68:904\u2013910","journal-title":"Phytochemistry"},{"key":"16_CR112","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1016\/S0968-0896(00)00171-1","volume":"8","author":"JF Sanz-Cervera","year":"2000","unstructured":"Winter JM, Moore BS (2007) Exploring the chemistry and biology of vanadium-dependent haloperoxidases. J Biol Chem 284(28):18577\u201318581","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"16_CR113","first-page":"187","volume":"47","author":"T Sassa","year":"1983","unstructured":"Bernhardt P, Okino T, Winter JM et\u00a0al (2011) A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis. J Am Chem Soc 133(12):4268\u20134270","journal-title":"Agric Biol Chem"},{"key":"16_CR114","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1021\/ja711188x","volume":"130","author":"AW Schultz","year":"2008","unstructured":"Wu Z, Li S, Li J et\u00a0al (2013) Antibacterial and cytotoxic new napyradiomycins from the marine-derived Streptomyces sp. SCSIO 10428. Mar Drugs 11:2113\u20132125","journal-title":"J Am Chem Soc"},{"issue":"4","key":"16_CR115","doi-asserted-by":"crossref","first-page":"494","DOI":"10.7164\/antibiotics.39.494","volume":"39","author":"K Shiomi","year":"1986","unstructured":"Motohashi K, Sue M, Furihata K et\u00a0al (2008) Terpenoids produced by actinomycetes: napyradiomycins from Streptomyces antimycoticus NT17. J Nat Prod 71:595\u2013601","journal-title":"J Antibiot"},{"key":"16_CR116","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1351\/pac199971061059","volume":"71","author":"K Shiomi","year":"1999","unstructured":"Fukuda DS, Mynderse JS, Baker PJ et\u00a0al (1990) A80915, a new antibiotic complex produced by Streptomyces aculeolatus: discovery, taxonomy, fermentation, isolation, characterization, and antibacterial evaluation. J Antibiot (Tokyo) 43(6):623\u2013633","journal-title":"Pure Appl Chem"},{"key":"16_CR117","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1039\/cs9871600123","volume":"16","author":"TJ Simpson","year":"1987","unstructured":"Haste NM, Farnaes L, Perera VR et\u00a0al (2011) Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. Mar Drugs 9:680\u2013689","journal-title":"Chem Soc Rev"},{"key":"16_CR118","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1021\/np060396d","volume":"70","author":"OF Smetanina","year":"2007","unstructured":"Hu Y, MacMillan JB (2011) Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp. Org Lett 13(24):6580\u20136583","journal-title":"J Nat Prod"},{"issue":"1","key":"16_CR119","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02975266","volume":"25","author":"BW Son","year":"2002","unstructured":"Hu Y, Legako AG, Espindola APDM et\u00a0al (2012) Erythrolic acids A\u2212E, meroterpenoids from a marine-derived Erythrobacter sp. J Org Chem 77:3401\u22123407","journal-title":"Arch Pharm Res"},{"key":"16_CR120","doi-asserted-by":"crossref","unstructured":"Kondratyuk TP, Park E-J, Yu R et\u00a0al (2012) Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. Mar Drugs 10:451\u2013464","DOI":"10.3390\/md10020451"},{"key":"16_CR121","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/np058011z","volume":"68","author":"IE Soria-Mercado","year":"2005","unstructured":"Imai S, Furihata K, Hayakawa Y et\u00a0al (1989) Lavanducyanin, a new antitumor substance produced by Streptomyces sp. J Antibiot (Tokyo) 42(7):1196\u20131198","journal-title":"J Nat Prod"},{"issue":"18s","key":"16_CR122","doi-asserted-by":"crossref","first-page":"14097","DOI":"10.1200\/jco.2007.25.18_suppl.14097","volume":"25","author":"MA Spear","year":"2007","unstructured":"Graber MA, Gerwick WH (1998) Kalkipyrone, a toxic \u03b3-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp. J Nat Prod 61:677\u2013680","journal-title":"J Clin Oncol"},{"key":"16_CR123","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.1016\/j.tetlet.2007.07.064","volume":"48","author":"RM Su\u00e1rez","year":"2007","unstructured":"Raju R, Piggott AM, Huang X-C et\u00a0al (2011) Nocardioazines: a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein. Org Lett 13(10):2770\u20132773","journal-title":"Tetrahedron Lett"},{"key":"16_CR124","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.bmcl.2011.12.083","volume":"22","author":"L-L Sun","year":"2012","unstructured":"Zhang Q, M\u00e1ndi A, Li S et\u00a0al (2012) N-N-Coupled indolo-sesquiterpene atropo-diastereomers from a marine-derived actinomycete. Eur J Org Chem 27:5256\u20135262","journal-title":"Bioorg Med Chem Lett"},{"key":"16_CR125","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1039\/c2np00086e","volume":"29","author":"SN Sunassee","year":"2012","unstructured":"Ding L, M\u00fcnch J, Goerls H et\u00a0al (2010) Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorg Med Chem Lett 15(20):6685\u20136687","journal-title":"Nat Prod Rep"},{"key":"16_CR126","doi-asserted-by":"crossref","unstructured":"Ding L, Maier A, Fiebig H-H et\u00a0al (2011) A family of multicyclic indolosesquiterpenes from a bacterial endophyte. Org Biomol Chem 9:4029\u20134031","DOI":"10.1039\/c1ob05283g"},{"key":"16_CR127","doi-asserted-by":"crossref","unstructured":"L\u00f3pez JMS, Insua MM, Baz JP et\u00a0al (2003) New cytotoxic indolic metabolites from a marine Streptomyces. J Nat Prod 66:863\u2013864","DOI":"10.1021\/np0204444"},{"issue":"2","key":"16_CR128","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1158\/0008-5472.CAN-10-1874","volume":"71","author":"MJ Towle","year":"2011","unstructured":"Renner MK, Shen Y-C, Cheng X-C et\u00a0al (1999) Cyclomarins A-C, new anti-inflammatory cyclic peptides produced by a marine bacterium (Streptomyces sp.). J Am Chem Soc 121:11273\u201311276","journal-title":"Cancer Res"},{"key":"16_CR129","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/np800471y","volume":"71","author":"S Tsukamoto","year":"2008","unstructured":"Genovese S, Curini M, Epifano F (2009) Chemistry and biological activity of azoprenylated secondary metabolites. Phytochemistry 70(9):1082\u20131091","journal-title":"J Nat Prod"},{"key":"16_CR130","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1021\/np4004728","volume":"76","author":"S Tsukamoto","year":"2013","unstructured":"Schultz AW, Oh D-C, Carney JR et\u00a0al (2008) Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J Am Chem Soc 130:4507\u20134516","journal-title":"J Nat Prod"},{"key":"16_CR131","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0027-5107(99)00017-2","volume":"424","author":"J-S Wang","year":"1999","unstructured":"Kwon HC, Espindola APDM, Park J-S et\u00a0al (2010) Nitropyrrolins A-E, cytotoxic farnesyl-\u03b1-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae. J Nat Prod 73:2047\u20132052","journal-title":"Mutat Res"},{"key":"16_CR132","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1021\/np060248n","volume":"69","author":"S Wang","year":"2006","unstructured":"Macherla VR, Liu J, Bellows C et\u00a0al (2005) Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment. J Nat Prod 68:780\u2013783","journal-title":"J Nat Prod"},{"key":"16_CR133","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1016\/j.tet.2008.06.013","volume":"64","author":"F Wang","year":"2008","unstructured":"Takahashi A, Kurasawa S, Ikeda D et\u00a0al (1989a) Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physic-chemical and biological properties. J Antibiot (Tokyo) 42(11):1556\u20131561","journal-title":"Tetrahedron"},{"issue":"9","key":"16_CR134","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/ja.2007.75","volume":"60","author":"H Wei","year":"2007","unstructured":"Takahashi A, Ikeda D, Nakamura H et\u00a0al (1989b) Altemicidin, a new acaricidal and antitumor substance. II. Structure determination. J Antibiot (Tokyo) 42(11):1562\u20131566","journal-title":"J Antibiot"},{"key":"16_CR135","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/md9030359","volume":"9","author":"R-B Wei","year":"2011","unstructured":"Charan RD, Schlingmann G, Janso J et\u00a0al (2004) Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp. J Nat Prod 67:1431\u20131433","journal-title":"Mar Drugs"},{"key":"16_CR136","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.procbio.2012.11.012","volume":"48","author":"I Wijesekara","year":"2013","unstructured":"Gourdeau H, McAlpine JB, Ranger M et\u00a0al (2008) Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand. Cancer Chemother Pharmacol 61:911\u2013921","journal-title":"Process Biochem"},{"issue":"3","key":"16_CR137","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1021\/ol991239r","volume":"2","author":"RT Willimanson","year":"2000","unstructured":"Bertomeu T, Zvereff V, Ibrahim A et\u00a0al (2010) TLN-4601 peripheral benzodiazepine receptor (PBR\/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation. Biochem Pharmacol 80:1572\u20131579","journal-title":"Org Lett"},{"issue":"28","key":"16_CR138","doi-asserted-by":"crossref","first-page":"18577","DOI":"10.1074\/jbc.R109.001602","volume":"284","author":"JM Winter","year":"2007","unstructured":"Kavan P, Melnychuk D, Langleben A et\u00a0al (2007) Phase I study of ECO-4601, a novel Ras pathway inhibitor. J Clin Oncol 24(18):14128","journal-title":"J Biol Chem"},{"issue":"15","key":"16_CR139","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1021\/jo00302a006","volume":"55","author":"AE Wright","year":"1990","unstructured":"Boufaied N, Wioland MMA, Gourdeau H (2010) TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation. Anticancer Drugs 21(5):543\u2013552","journal-title":"J Org Chem"},{"key":"16_CR140","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.3390\/md11062113","volume":"11","author":"Z Wu","year":"2013","unstructured":"Campbell PM, Boufaied N, Fiordalisi JJ et\u00a0al (2010) TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal 5:18","journal-title":"Mar Drugs"},{"key":"16_CR141","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ja.2006.63","volume":"59","author":"JZ Xu","year":"2006","unstructured":"Mason W (2008) Efficacy study of TLN-4601 in patients with Recurring Glioblastoma Multiforme. NCT00730262","journal-title":"J Antibiot"},{"issue":"9","key":"16_CR142","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.bmc.2010.03.037","volume":"18","author":"Y Yamazaki","year":"2010","unstructured":"Okumura H, Kobaru S (Bristol-Meyers Squibb Co.) Compound produced by a strain of Micromonospora. U.S. Patent 5,541, 181, 30 July 1996","journal-title":"Bioorg Med Chem"},{"key":"16_CR143","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1021\/np700737g","volume":"71","author":"M Zhang","year":"2008","unstructured":"Igarashi Y, Miyanaga S, Onaka H et\u00a0al (2005) Revision of the structure assigned to the antibiotic BU-4664 L from Micromonopora. J Antibiot 58(5):350\u2013352","journal-title":"J Nat Prod"},{"key":"16_CR144","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1002\/ejoc.201200599","volume":"27","author":"Q Zhang","year":"2012","unstructured":"Wei R-B, Xi T, Li J et\u00a0al (2011) Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17. Mar Drugs 9:359\u201336827","journal-title":"Eur J Org Chem"}],"container-title":["Handbook of Anticancer Drugs from Marine Origin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-07145-9_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T10:01:55Z","timestamp":1674554515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-07145-9_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,28]]},"ISBN":["9783319071442","9783319071459"],"references-count":144,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-07145-9_16","relation":{},"subject":[],"published":{"date-parts":[[2014,11,28]]},"assertion":[{"value":"28 November 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}