{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:52:32Z","timestamp":1778619152720,"version":"3.51.4"},"publisher-location":"Cham","reference-count":62,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319447834","type":"print"},{"value":"9783319447858","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-44785-8_8","type":"book-chapter","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T14:48:27Z","timestamp":1474901307000},"page":"147-161","source":"Crossref","is-referenced-by-count":5,"title":["Pre-clinical and Clinical Management of Osteochondral Lesions"],"prefix":"10.1007","author":[{"given":"Sandra","family":"Pina","sequence":"first","affiliation":[]},{"given":"Viviana","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Joaquim Miguel","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Rui Lu\u00eds","family":"Reis","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"issue":"5","key":"8_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.bioeng.2007.07.014","volume":"24","author":"W Swieszkowski","year":"2007","unstructured":"Swieszkowski W, Tuan BHS, Kurzydlowski KJ, Hutmacher DW (2007) Repair and regeneration of osteochondral defects in the articular joints. Biomol Eng 24(5):489\u2013495. doi: 10.1016\/j.bioeng.2007.07.014","journal-title":"Biomol Eng"},{"issue":"6","key":"8_CR2","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1007\/s00167-011-1655-1","volume":"20","author":"S Panseri","year":"2012","unstructured":"Panseri S, Russo A, Cunha C, Bondi A, Di Martino A, Patella S, Kon E (2012) Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surg Sport Traumatol Arthrosc 20(6):1182\u20131191. doi: 10.1007\/s00167-011-1655-1","journal-title":"Knee Surg Sport Traumatol Arthrosc"},{"issue":"1","key":"8_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.csm.2004.08.007","volume":"24","author":"AD Pearle","year":"2005","unstructured":"Pearle AD, Warren RF, Rodeo SA (2005) Basic science of articular cartilage and osteoarthritis. Clin Sport Med 24(1):1\u201312. doi: 10.1016\/j.csm.2004.08.007","journal-title":"Clin Sport Med"},{"issue":"11","key":"8_CR4","doi-asserted-by":"publisher","first-page":"868","DOI":"10.3928\/01477447-20131021-10","volume":"36","author":"M Liu","year":"2013","unstructured":"Liu M, Yu X, Huang FG, Cen SQ, Zhong G, Xiang Z (2013) Tissue engineering stratified scaffolds for articular cartilage and subchondral bone defects repair. Orthopedics 36(11):868\u2013873. doi: 10.3928\/01477447-20131021-10","journal-title":"Orthopedics"},{"issue":"9","key":"8_CR5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/jbm.820290915","volume":"29","author":"CR Chu","year":"1995","unstructured":"Chu CR, Coutts RD, Yoshioka M, Harwood FL, Monosov AZ, Amiel D (1995) Articular cartilage repair using allogeneic perichondrocyteseeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. J Biomed Mater Res 29(9):1147\u20131154","journal-title":"J Biomed Mater Res"},{"issue":"24","key":"8_CR6","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1016\/S0142-9612(02)00223-5","volume":"23","author":"JK Sherwood","year":"2002","unstructured":"Sherwood JK, Riley SL, Palazzolo R, Brown SC, Monkhouse DC, Coates M, Griffith LG, Landeen LK, Ratcliffe A (2002) A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 23(24):4739\u20134751","journal-title":"Biomaterials"},{"issue":"2","key":"8_CR7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jbm.a.32869","volume":"95","author":"LP Yan","year":"2010","unstructured":"Yan LP, Wang YJ, Ren L, Wu G, Caridade SG, Fan JB, Wang LY, Ji PH, Oliveira JM, Oliveira JT (2010) Genipin-cross-linked collagen\/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. J Biomed Mater Res Part A 95(2):465\u2013475","journal-title":"J Biomed Mater Res Part A"},{"issue":"1","key":"8_CR8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.actbio.2011.09.037","volume":"8","author":"L-P Yan","year":"2012","unstructured":"Yan L-P, Oliveira JM, Oliveira AL, Caridade SG, Mano JF, Reis RL (2012) Macro\/microporous silk fibroin scaffolds with potential for articular cartilage and meniscus tissue engineering applications. Acta Biomater 8(1):289\u2013301","journal-title":"Acta Biomater"},{"issue":"5","key":"8_CR9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1089\/ten.teb.2013.0543","volume":"20","author":"K Shimomura","year":"2014","unstructured":"Shimomura K, Moriguchi Y, Murawski CD, Yoshikawa H, Nakamura N (2014) Osteochondral tissue engineering with biphasic scaffold: current strategies and techniques. Tissue Eng Part B Rev 20(5):468\u2013476","journal-title":"Tissue Eng Part B Rev"},{"issue":"12","key":"8_CR10","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.joca.2014.06.034","volume":"22","author":"R Moyer","year":"2014","unstructured":"Moyer R, Ratneswaran A, Beier F, Birmingham T (2014) Osteoarthritis year in review 2014: mechanics\u2013basic and clinical studies in osteoarthritis. Osteoarth Cartil 22(12):1989\u20132002","journal-title":"Osteoarth Cartil"},{"issue":"5","key":"8_CR11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.aanat.2008.07.007","volume":"190","author":"C Csaki","year":"2008","unstructured":"Csaki C, Schneider P, Shakibaei M (2008) Mesenchymal stem cells as a potential pool for cartilage tissue engineering. Ann Anat-Anatomischer Anzeiger 190(5):395\u2013412","journal-title":"Ann Anat-Anatomischer Anzeiger"},{"issue":"9","key":"8_CR12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.joca.2007.06.014","volume":"15","author":"W Zhang","year":"2007","unstructured":"Zhang W, Moskowitz R, Nuki G, Abramson S, Altman R, Arden N, Bierma-Zeinstra S, Brandt K, Croft P, Doherty M (2007) OARSI recommendations for the management of hip and knee osteoarthritis. Part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarth Cartil 15(9):981\u20131000","journal-title":"Osteoarth Cartil"},{"issue":"2","key":"8_CR13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.joca.2007.12.013","volume":"16","author":"W Zhang","year":"2008","unstructured":"Zhang W, Moskowitz R, Nuki G, Abramson S, Altman R, Arden N, Bierma-Zeinstra S, Brandt K, Croft P, Doherty M (2008) OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines. Osteoarth Cartil 16(2):137\u2013162","journal-title":"Osteoarth Cartil"},{"issue":"4","key":"8_CR14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","volume":"18","author":"W Zhang","year":"2010","unstructured":"Zhang W, Nuki G, Moskowitz R, Abramson S, Altman R, Arden N, Bierma-Zeinstra S, Brandt K, Croft P, Doherty M (2010) OARSI recommendations for the management of hip and knee osteoarthritis. Part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarth Cartil 18(4):476\u2013499","journal-title":"Osteoarth Cartil"},{"issue":"23\u201332","key":"8_CR15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.22203\/eCM.v009a04","volume":"9","author":"S Redman","year":"2005","unstructured":"Redman S, Oldfield S, Archer C (2005) Current strategies for articular cartilage repair. Eur Cell Mater 9(23\u201332):23\u201332","journal-title":"Eur Cell Mater"},{"issue":"31","key":"8_CR16","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1016\/j.biomaterials.2010.07.017","volume":"31","author":"K Shimomura","year":"2010","unstructured":"Shimomura K, Ando W, Tateishi K, Nansai R, Fujie H, Hart DA, Kohda H, Kita K, Kanamoto T, Mae T (2010) The influence of skeletal maturity on allogenic synovial mesenchymal stem cell-based repair of cartilage in a large animal model. Biomaterials 31(31):8004\u20138011","journal-title":"Biomaterials"},{"issue":"8","key":"8_CR17","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1007\/s00167-012-2031-5","volume":"21","author":"L Xing","year":"2013","unstructured":"Xing L, Jiang Y, Gui J, Lu Y, Gao F, Xu Y, Xu Y (2013) Microfracture combined with osteochondral paste implantation was more effective than microfracture alone for full-thickness cartilage repair. Knee Surg Sports Traumatol Arthrosc 21(8):1770\u20131776","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"8","key":"8_CR18","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1177\/0363546512449292","volume":"40","author":"YS Kim","year":"2012","unstructured":"Kim YS, Park EH, Lee HJ, Koh YG, Lee JW (2012) Clinical comparison of the osteochondral autograft transfer system and subchondral drilling in osteochondral defects of the first metatarsal head. Am J Sports Med 40(8):1824\u20131833","journal-title":"Am J Sports Med"},{"issue":"11","key":"8_CR19","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1007\/s00167-012-2143-y","volume":"20","author":"L Girolamo De","year":"2012","unstructured":"De Girolamo L, Quaglia A, Bait C, Cervellin M, Prospero E, Volpi P (2012) Modified autologous matrix-induced chondrogenesis (AMIC) for the treatment of a large osteochondral defect in a varus knee: a case report. Knee Surg Sports Traumatol Arthrosc 20(11):2287\u20132290","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5","key":"8_CR20","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1053\/j.jfas.2012.05.013","volume":"51","author":"M Miska","year":"2012","unstructured":"Miska M, Wiewiorski M, Valderrabano V (2012) Reconstruction of a large osteochondral lesion of the distal tibia with an iliac crest graft and autologous matrix-induced chondrogenesis (AMIC): a case report. J Foot Ankle Surg 51(5):680\u2013683","journal-title":"J Foot Ankle Surg"},{"issue":"6","key":"8_CR21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1007\/s00167-011-1692-9","volume":"20","author":"BB Christensen","year":"2012","unstructured":"Christensen BB, Foldager CB, Hansen OM, Kristiansen AA, Le DQS, Nielsen AD, Nygaard JV, B\u00fcnger CE, Lind M (2012) A novel nano-structured porous polycaprolactone scaffold improves hyaline cartilage repair in a rabbit model compared to a collagen type I\/III scaffold: in vitro and in vivo studies. Knee Surg Sports Traumatol Arthrosc 20(6):1192\u20131204","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"8_CR22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/jars.2003.50022","volume":"19","author":"RW Jackson","year":"2003","unstructured":"Jackson RW, Dieterichs C (2003) The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration. Arthrosc J Arthrosc Relat Surg 19(1):13\u201320","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"4","key":"8_CR23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s002640000212","volume":"25","author":"F Shannon","year":"2001","unstructured":"Shannon F, Devitt A, Poynton A, Fitzpatrick P, Walsh M (2001) Short-term benefit of arthroscopic washout in degenerative arthritis of the knee. Int Orthop 25(4):242\u2013245","journal-title":"Int Orthop"},{"issue":"4","key":"8_CR24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s001670050061","volume":"5","author":"L Hangody","year":"1997","unstructured":"Hangody L, Kish G, Karpati Z, Szerb I, Udvarhelyi I (1997) Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects A preliminary report. Knee Surg Sports Traumatol Arthrosc 5(4):262\u2013267","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"8_CR25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1053\/j.otsm.2012.03.009","volume":"20","author":"T Minas","year":"2012","unstructured":"Minas T, Peterson L (2012) Autologous chondrocyte transplantation. Oper Tech Sports Med 20(1):72\u201386","journal-title":"Oper Tech Sports Med"},{"issue":"4","key":"8_CR26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.knee.2011.03.011","volume":"19","author":"AM Getgood","year":"2012","unstructured":"Getgood AM, Kew SJ, Brooks R, Aberman H, Simon T, Lynn AK, Rushton N (2012) Evaluation of early-stage osteochondral defect repair using a biphasic scaffold based on a collagen\u2013glycosaminoglycan biopolymer in a caprine model. Knee 19(4):422\u2013430","journal-title":"Knee"},{"issue":"3","key":"8_CR27","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s11999-011-2107-4","volume":"470","author":"A Siclari","year":"2012","unstructured":"Siclari A, Mascaro G, Gentili C, Cancedda R, Boux E (2012) A cell-free scaffold-based cartilage repair provides improved function hyaline-like repair at one year. Clin Orthop Relat Res\u00ae 470(3):910\u2013919","journal-title":"Clin Orthop Relat Res\u00ae"},{"issue":"4","key":"8_CR28","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.jbiomech.2006.03.008","volume":"40","author":"I Martin","year":"2007","unstructured":"Martin I, Miot S, Barbero A, Jakob M, Wendt D (2007) Osteochondral tissue engineering. J Biomech 40(4):750\u2013765. doi: 10.1016\/j.jbiomech.2006.03.008","journal-title":"J Biomech"},{"issue":"5","key":"8_CR29","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1590\/S0102-86502013000500004","volume":"28","author":"A Sotoudeh","year":"2013","unstructured":"Sotoudeh A, Jahanshahi A, Takhtfooladi MA, Bazazan A, Ganjali A, Harati MP (2013) Study on nano-structured hydroxyapatite\/zirconia stabilized yttria on healing of articular cartilage defect in rabbit. Acta Cir Bras 28(5):340\u2013345","journal-title":"Acta Cir Bras"},{"issue":"6","key":"8_CR30","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s10439-010-0038-y","volume":"38","author":"J Jiang","year":"2010","unstructured":"Jiang J, Tang A, Ateshian GA, Guo XE, Hung CT, Lu HH (2010) Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair. Ann Biomed Eng 38(6):2183\u20132196","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"8_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00256-011-1272-6","volume":"41","author":"H Nejadnik","year":"2012","unstructured":"Nejadnik H, Daldrup-Link HE (2012) Engineering stem cells for treatment of osteochondral defects. Skeletal Radiol 41(1):1\u20134","journal-title":"Skeletal Radiol"},{"issue":"1","key":"8_CR32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/ten.teb.2008.0388","volume":"15","author":"M Keeney","year":"2009","unstructured":"Keeney M, Pandit A (2009) The osteochondral junction and its repair via bi-phasic tissue engineering scaffolds. Tissue Eng Part B Rev 15(1):55\u201373","journal-title":"Tissue Eng Part B Rev"},{"issue":"2","key":"8_CR33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2008.10.021","volume":"134","author":"X Wang","year":"2009","unstructured":"Wang X, Wenk E, Zhang X, Meinel L, Vunjak-Novakovic G, Kaplan DL (2009) Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Controll Release 134(2):81\u201390","journal-title":"J Controll Release"},{"issue":"2","key":"8_CR34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jbm.b.31552","volume":"92","author":"GI Im","year":"2010","unstructured":"Im GI, Lee JH (2010) Repair of osteochondral defects with adipose stem cells and a dual growth factor-releasing scaffold in rabbits. J Biomed Mater Res B Appl Biomater 92(2):552\u2013560","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"21\u201322","key":"8_CR35","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1089\/ten.tea.2011.0135","volume":"17","author":"N Mohan","year":"2011","unstructured":"Mohan N, Dormer NH, Caldwell KL, Key VH, Berkland CJ, Detamore MS (2011) Continuous gradients of material composition and growth factors for effective regeneration of the osteochondral interface. Tissue Eng Part A 17(21\u201322):2845\u20132855","journal-title":"Tissue Eng Part A"},{"key":"8_CR36","doi-asserted-by":"crossref","unstructured":"Sch\u00fctz K, Despang F, Lode A, Gelinsky M (2016) Cell\u2010laden biphasic scaffolds with anisotropic structure for the regeneration of osteochondral tissue. J Tissue Eng Regen Med 10(5):404\u2013417","DOI":"10.1002\/term.1879"},{"issue":"3","key":"8_CR37","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/Jbm.A.32387","volume":"92A","author":"BA Harley","year":"2010","unstructured":"Harley BA, Lynn AK, Wissner-Gross Z, Bonfield W, Yannas IV, Gibson LJ (2010) Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces. J Biomed Mater Res A 92A(3):1078\u20131093. doi: 10.1002\/Jbm.A.32387","journal-title":"J Biomed Mater Res A"},{"issue":"4","key":"8_CR38","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tibtech.2007.12.009","volume":"26","author":"WL Grayson","year":"2008","unstructured":"Grayson WL, Chao PHG, Marolt D, Kaplan DL, Vunjak-Novakovic G (2008) Engineering custom-designed osteochondral tissue grafts. Trends Biotechnol 26(4):181\u2013189. doi: 10.1016\/j.tibtech.2007.12.009","journal-title":"Trends Biotechnol"},{"issue":"5","key":"8_CR39","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.biotechadv.2012.11.004","volume":"31","author":"SP Nukavarapu","year":"2013","unstructured":"Nukavarapu SP, Dorcemus DL (2013) Osteochondral tissue engineering: Current strategies and challenges. Biotechnol Adv 31(5):706\u2013721. doi: 10.1016\/j.biotechadv.2012.11.004","journal-title":"Biotechnol Adv"},{"issue":"10","key":"8_CR40","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1111\/j.1582-4934.2012.01571.x","volume":"16","author":"P Nooeaid","year":"2012","unstructured":"Nooeaid P, Salih V, Beier JP, Boccaccini AR (2012) Osteochondral tissue engineering: scaffolds, stem cells and applications. J Cell Mol Med 16(10):2247\u20132270. doi: 10.1111\/j.1582-4934.2012.01571.x","journal-title":"J Cell Mol Med"},{"key":"8_CR41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2002.tb03079.x","volume":"961","author":"SA Goldstein","year":"2002","unstructured":"Goldstein SA (2002) Tissue engineering\u2014functional assessment and clinical outcome. Ann N Y Acad Sci 961:183\u2013192","journal-title":"Ann N Y Acad Sci"},{"key":"8_CR42","doi-asserted-by":"crossref","unstructured":"Sosio C, Di Giancamillo A, Deponti D, Gervaso F, Scalera F, Melato M, Campagnol M, Boschetti F, Nonis A, Domeneghini C, Sannino A, Peretti GM (2015) Osteochondral repair by a novel interconnecting collagen-hydroxyapatite substitute: a large-animal study. (1937-335X (Electronic))","DOI":"10.1089\/ten.tea.2014.0129"},{"issue":"3","key":"8_CR43","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.rvsc.2013.08.016","volume":"95","author":"Seo J-P","year":"2013","unstructured":"J-P Seo, Tanabe T, Tsuzuki N, Haneda S, Yamada K, Furuoka H, Tabata Y, Sasaki N (2013) Effects of bilayer gelatin\/\u03b2-tricalcium phosphate sponges loaded with mesenchymal stem cells, chondrocytes, bone morphogenetic protein-2, and platelet rich plasma on osteochondral defects of the talus in horses. Res Vet Sci 95(3):1210\u20131216. doi: 10.1016\/j.rvsc.2013.08.016","journal-title":"Res Vet Sci"},{"key":"8_CR44","doi-asserted-by":"publisher","unstructured":"Jeon JE, Vaquette C, Theodoropoulos C, Klein TJ, Hutmacher DW (2014) Multiphasic construct studied in an ectopic osteochondral defect model, vol 11. vol 95. doi: 10.1098\/rsif.2014.0184","DOI":"10.1098\/rsif.2014.0184"},{"issue":"7","key":"8_CR45","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1007\/s10856-014-5192-6","volume":"25","author":"I Dresing","year":"2014","unstructured":"Dresing I, Zeiter S, Auer J, Alini M, Eglin D (2014) Evaluation of a press-fit osteochondral poly(ester-urethane) scaffold in a rabbit defect model. J Mater Sci Mater Med 25(7):1691\u20131700. doi: 10.1007\/s10856-014-5192-6","journal-title":"J Mater Sci Mater Med"},{"issue":"6","key":"8_CR46","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1007\/s00167-013-2426-y","volume":"22","author":"KM Jang","year":"2014","unstructured":"Jang KM, Lee JH, Park CM, Song HR, Wang JH (2014) Xenotransplantation of human mesenchymal stem cells for repair of osteochondral defects in rabbits using osteochondral biphasic composite constructs. Knee Surg Sport Traumatol Arthrosc 22(6):1434\u20131444. doi: 10.1007\/s00167-013-2426-y","journal-title":"Knee Surg Sport Traumatol Arthrosc"},{"key":"8_CR47","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/746138","author":"WJ Zhang","year":"2014","unstructured":"Zhang WJ, Lian Q, Li DC, Wang KZ, Hao DJ, Bian WG, He JK, Jin ZM (2014) Cartilage repair and subchondral bone migration using 3D printing osteochondral composites: a one-year-period study in rabbit trochlea. Biomed Res Int. doi: 10.1155\/2014\/746138","journal-title":"Biomed Res Int"},{"issue":"7","key":"8_CR48","doi-asserted-by":"publisher","first-page":"7236","DOI":"10.1016\/j.actbio.2013.04.003","volume":"9","author":"SF Zhang","year":"2013","unstructured":"Zhang SF, Chen LK, Jiang YZ, Cai YZ, Xu GW, Tong T, Zhang W, Wang LL, Ji JF, Shi PH, Ouyang HW (2013) Bi-layer collagen\/microporous electrospun nanofiber scaffold improves the osteochondral regeneration. Acta Biomater 9(7):7236\u20137247. doi: 10.1016\/j.actbio.2013.04.003","journal-title":"Acta Biomater"},{"issue":"2","key":"8_CR49","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jconrel.2013.03.013","volume":"168","author":"K Kim","year":"2013","unstructured":"Kim K, Lam J, Lu S, Spicer PP, Lueckgen A, Tabata Y, Wong ME, Jansen JA, Mikos AG, Kasper FK (2013) Osteochondral tissue regeneration using a bilayered composite hydrogel with modulating dual growth factor release kinetics in a rabbit model. J Control Release 168(2):166\u2013178. doi: 10.1016\/j.jconrel.2013.03.013","journal-title":"J Control Release"},{"issue":"25","key":"8_CR50","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1016\/j.biomaterials.2013.04.055","volume":"34","author":"W Zhang","year":"2013","unstructured":"Zhang W, Chen JL, Tao JD, Hu CC, Chen LK, Zhao HS, Xu GW, Heng BC, Ouyang HW (2013) The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold. Biomaterials 34(25):6046\u20136057. doi: 10.1016\/j.biomaterials.2013.04.055","journal-title":"Biomaterials"},{"issue":"21","key":"8_CR51","doi-asserted-by":"publisher","first-page":"4793","DOI":"10.1016\/j.biomaterials.2011.03.041","volume":"32","author":"JN Chen","year":"2011","unstructured":"Chen JN, Chen HA, Li P, Diao HJ, Zhu SY, Dong L, Wang R, Guo T, Zhao JN, Zhang JF (2011) Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 32(21):4793\u20134805. doi: 10.1016\/j.biomaterials.2011.03.041","journal-title":"Biomaterials"},{"key":"8_CR52","doi-asserted-by":"crossref","unstructured":"Kon E, Filardo G, Robinson D, Eisman JA, Levy A, Zaslav K, Shani J, Altschuler N (2015) Osteochondral regeneration using a novel aragonite-hyaluronate bi-phasic scaffold in a goat model. (1433-7347 (Electronic))","DOI":"10.1186\/s13018-015-0211-y"},{"issue":"2","key":"8_CR53","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s10616-013-9581-3","volume":"66","author":"C Fonseca","year":"2014","unstructured":"Fonseca C, Caminal M, Peris D, Barrachina J, Fabregas PJ, Garcia F, Cairo JJ, Godia F, Pla A, Vives J (2014) An arthroscopic approach for the treatment of osteochondral focal defects with cell-free and cell-loaded PLGA scaffolds in sheep. Cytotechnology 66(2):345\u2013354. doi: 10.1007\/s10616-013-9581-3","journal-title":"Cytotechnology"},{"issue":"1","key":"8_CR54","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jss.2012.11.036","volume":"183","author":"I Schleicher","year":"2013","unstructured":"Schleicher I, Lips KS, Sommer U, Schappat I, Martin AP, Szalay G, Hartmann S, Schnettler R (2013) Biphasic scaffolds for repair of deep osteochondral defects in a sheep model. J Surg Res 183(1):184\u2013192","journal-title":"J Surg Res"},{"issue":"7","key":"8_CR55","doi-asserted-by":"publisher","first-page":"7490","DOI":"10.1016\/j.actbio.2013.03.021","volume":"9","author":"A Bernstein","year":"2013","unstructured":"Bernstein A, Niemeyer P, Salzmann G, S\u00fcdkamp NP, Hube R, Klehm J, Menzel M, von Eisenhart-Rothe R, Bohner M, G\u00f6rz L, Mayr HO (2013) Microporous calcium phosphate ceramics as tissue engineering scaffolds for the repair of osteochondral defects: Histological results. Acta Biomater 9(7):7490\u20137505. doi: 10.1016\/j.actbio.2013.03.021","journal-title":"Acta Biomater"},{"key":"8_CR56","doi-asserted-by":"crossref","unstructured":"Gotterbarm T, Breusch SJ, Jung M, Streich N, Wiltfang J, Berardi Vilei S, Richter W, Nitsche T (2014) Complete subchondral bone defect regeneration with a tricalcium phosphate collagen implant and osteoinductive growth factors: a randomized controlled study in Gottingen minipigs. (1552-4981 (Electronic))","DOI":"10.1002\/jbm.b.33074"},{"issue":"7","key":"8_CR57","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.injury.2009.11.014","volume":"41","author":"E Kon","year":"2010","unstructured":"Kon E, Delcogliano M, Filardo G, Pressato D, Busacca M, Grigolo B, Desando G, Marcacci M (2010) A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. Injury 41(7):693\u2013701. doi: 10.1016\/j.injury.2009.11.014","journal-title":"Injury"},{"key":"8_CR58","first-page":"563","volume":"57","author":"RJ Williams","year":"2008","unstructured":"Williams RJ, Gamradt SC (2008) Articular cartilage repair using a resorbable matrix scaffold. Instr Course Lect 57:563\u2013571","journal-title":"Instr Course Lect"},{"issue":"3","key":"8_CR59","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1586\/erd.10.15","volume":"7","author":"JTK Melton","year":"2010","unstructured":"Melton JTK, Wilson AJ, Chapman-Sheath P, Cossey AJ (2010) TruFit CB\u00ae bone plug: chondral repair, scaffold design, surgical technique and early experiences. Expert Rev Med Devices 7(3):333\u2013341. doi: 10.1586\/erd.10.15","journal-title":"Expert Rev Med Devices"},{"key":"8_CR60","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.injury.2009.11.014","volume":"41","author":"E Kon","year":"2010","unstructured":"Kon E, Delcogliano M, Filardo G, Pressato D, Busacca M, Grigolo B, Desando G, Marcacci M (2010) A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. Injury 41:693\u2013701","journal-title":"Injury"},{"key":"8_CR61","unstructured":"Ostrovsky G (2010) Bioresorbable, acellular, biphasic scaffold gets EU approval for knee cartilage repair. medGadget. Accessed 25 Nov 2014"},{"issue":"2","key":"8_CR62","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1053\/j.otsm.2013.03.002","volume":"21","author":"AH Gomoll","year":"2013","unstructured":"Gomoll AH (2013) Osteochondral allograft transplantation using the chondrofix implant. Oper Tech Sports Med 21(2):90\u201394. doi: 10.1053\/j.otsm.2013.03.002","journal-title":"Oper Tech Sports Med"}],"container-title":["Studies in Mechanobiology, Tissue Engineering and Biomaterials","Regenerative Strategies for the Treatment of Knee Joint Disabilities"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-44785-8_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T16:04:52Z","timestamp":1718813092000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-44785-8_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,27]]},"ISBN":["9783319447834","9783319447858"],"references-count":62,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-44785-8_8","relation":{},"ISSN":["1868-2006","1868-2014"],"issn-type":[{"value":"1868-2006","type":"print"},{"value":"1868-2014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,27]]}}}