{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T04:49:38Z","timestamp":1766551778236},"publisher-location":"Cham","reference-count":56,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319555294"},{"type":"electronic","value":"9783319555300"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-319-55530-0_11","type":"book-chapter","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:43:40Z","timestamp":1546631020000},"page":"1997-2015","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ginkgo biloba, DNA Damage and DNA Repair: Overview"],"prefix":"10.1007","author":[{"given":"Daniela","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Bjorn","family":"Johansson","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,1,5]]},"reference":[{"key":"11_CR1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.phymed.2011.11.011","volume":"19","author":"BA Abdel-Wahab","year":"2012","unstructured":"Abdel-Wahab BA, Abd El-Aziz SM (2012) Ginkgo biloba protects against intermittent hypoxia-induced memory deficits and hippocampal DNA damage in rats. Phytomedicine 19:444\u2013450","journal-title":"Phytomedicine"},{"key":"11_CR2","first-page":"7","volume":"2","author":"SS Alam","year":"2013","unstructured":"Alam SS, Hassan NS, Raafat BM (2013) Evaluation of oxidatively generated damage to DNA and proteins in rat liver induced by exposure to technetium radioisotope 99m and protective role of Angelica archangelica and Ginkgo biloba. WASJ 2:7\u201317","journal-title":"WASJ"},{"key":"11_CR3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mnfr.201300195","volume":"58","author":"VBO Ayissi","year":"2014","unstructured":"Ayissi VBO, Ebrahimi A, Schluesenner H (2014) Epigenetic effects of natural polyphenols: a focus on SIRT1-mediated mechanisms. Mol Nutr Food Res 58:22\u201332","journal-title":"Mol Nutr Food Res"},{"key":"11_CR4","first-page":"8","volume":"2","author":"GG Bahri","year":"2014","unstructured":"Bahri GG, Lamuki MS, Rezae-Raad MS (2014) Anti-proliferative effects of alcoholic and aqueous extract of Ginkgo biloba green leaves on MCF-7 cell line. IJMPR 2:8\u201311","journal-title":"IJMPR"},{"key":"11_CR5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1078\/0944-7113-00022","volume":"8","author":"G Baron-Ruppert","year":"2001","unstructured":"Baron-Ruppert G, Luepke N-P (2001) Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen\u2019s egg test (HET). Phytomedicine 8:133\u2013138","journal-title":"Phytomedicine"},{"key":"11_CR6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jnutbio.2012.07.001","volume":"24","author":"A Berger","year":"2013","unstructured":"Berger A, Venturelli S, Kallnischkies M et al (2013) Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases. J Nutr Biochem 24:977\u2013985","journal-title":"J Nutr Biochem"},{"key":"11_CR7","doi-asserted-by":"crossref","first-page":"e7998","DOI":"10.1371\/journal.pone.0007998","volume":"4","author":"C Bidon","year":"2009","unstructured":"Bidon C, Lachuer J, Molgo J et al (2009) The extract of Ginkgo biloba EGb 761 reactivates a juvenile profile in the skeletal muscle of sarcopenic rats by transcriptional reprogramming. PLoS One 4:e7998","journal-title":"PLoS One"},{"key":"11_CR8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.celrep.2016.04.047","volume":"15","author":"S Boeing","year":"2016","unstructured":"Boeing S, Williamson L, Encheva V et al (2016) Multiomic analysis of the UV-induced DNA damage response. Cell Rep 15:1597\u20131610","journal-title":"Cell Rep"},{"key":"11_CR9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/cbf.2907","volume":"31","author":"NAE Boghdady","year":"2013","unstructured":"Boghdady NAE (2013) Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell Biochem Funct 31:344\u2013351","journal-title":"Cell Biochem Funct"},{"key":"11_CR10","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.1523\/JNEUROSCI.5214-12.2013","volume":"33","author":"C Brochier","year":"2013","unstructured":"Brochier C, Dennis G, Rivieccio MA et al (2013) Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci 33:8621\u20138632","journal-title":"J Neurosci"},{"key":"11_CR11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13148-015-0095-z","volume":"7","author":"C Busch","year":"2015","unstructured":"Busch C, Burkard M, Leischner C et al (2015) Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clin Epigenetics 7:64","journal-title":"Clin Epigenetics"},{"key":"11_CR12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.expneurol.2012.05.004","volume":"236","author":"I Carrero","year":"2012","unstructured":"Carrero I, Gonzalo MR, Martin B et al (2012) Oligomers of beta-amyloid protein (A\u03b21-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain. Exp Neurol 236:215\u2013227","journal-title":"Exp Neurol"},{"key":"11_CR13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1089\/jmf.2010.0202","volume":"14","author":"K \u00c7avu\u015fo\u011flu","year":"2011","unstructured":"\u00c7avu\u015fo\u011flu K, Yapar K, Oru\u00e7 E et al (2011) Protective effect of Ginkgo biloba L. leaf extract against glyphosate toxicity in Swiss albino mice. J Med Food 14:1263\u20131272","journal-title":"J Med Food"},{"key":"11_CR14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1175371","volume":"325","author":"C Choudhary","year":"2009","unstructured":"Choudhary C, Kumar C, Gnad F et al (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834\u2013840","journal-title":"Science"},{"key":"11_CR15","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1210\/jc.2007-0597","volume":"92","author":"A Dardano","year":"2007","unstructured":"Dardano A, Ballardin M, Ferdeghini M et al (2007) Anticlastogenic effect of Ginkgo biloba extract in graves\u2019 disease patients receiving radioiodine therapy. J Clin Endocrinol Metab 92:4286\u20134289","journal-title":"J Clin Endocrinol Metab"},{"key":"11_CR16","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1074\/jbc.M510127200","volume":"281","author":"V Dorval","year":"2006","unstructured":"Dorval V, Fraser PE (2006) Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and \u03b1-synuclein. J Biol Chem 281:9919\u20139924","journal-title":"J Biol Chem"},{"key":"11_CR17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1475-2867-11-38","volume":"11","author":"HO Mesallamy El","year":"2011","unstructured":"El Mesallamy HO, Metwally NS, Soliman MS et al (2011) The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats. Cancer Cell Int 11:38","journal-title":"Cancer Cell Int"},{"key":"11_CR18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1586\/17469899.2015.1043994","volume":"10","author":"L Fang","year":"2015","unstructured":"Fang L, Neutzner A, Turtschi S et al (2015) The effect of Ginkgo biloba and Nifedipine on DNA breaks in circulating leukocytes of glaucoma patients. Expert Rev Ophthalmol 10:313\u2013318","journal-title":"Expert Rev Ophthalmol"},{"key":"11_CR19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.chembiol.2009.01.009","volume":"16","author":"I Fukuda","year":"2009","unstructured":"Fukuda I, Ito A, Hirai G et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem Biol 16:133\u2013140","journal-title":"Chem Biol"},{"key":"11_CR20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/emmm.201201923","volume":"5","author":"N Govindarajan","year":"2013","unstructured":"Govindarajan N, Rao P, Burkhardt S et al (2013) Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer\u2019s disease. EMBO Mol Med 5:52\u201363","journal-title":"EMBO Mol Med"},{"key":"11_CR56","doi-asserted-by":"crossref","unstructured":"He J, Lin J, Li J et al (2009) Dual effects of Ginkgo biloba leaf extract on human red blood cells. Basic Clin Pharmacol Toxicol 104:138\u2013144","DOI":"10.1111\/j.1742-7843.2008.00354.x"},{"key":"11_CR21","first-page":"203","volume":"69","author":"Y-T He","year":"2014","unstructured":"He Y-T, Xing S-S, Gao L et al (2014) Ginkgo biloba attenuates oxidative DNA damage of human umbilical vein endothelial cells induced by intermittent high glucose. Pharmazie 69:203\u2013207","journal-title":"Pharmazie"},{"key":"11_CR22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/CEJ.0b013e328348fbb7","volume":"20","author":"W Jiang","year":"2011","unstructured":"Jiang W, Qiu W, Wang Y et al (2011) Ginkgo may prevent genetic-associated ovarian cancer risk: multiple biomarkers and anticancer pathways induced by ginkgolide B in BRCA1-mutant ovarian epithelial cells. Eur J Cancer Prev 20:508\u2013517","journal-title":"Eur J Cancer Prev"},{"key":"11_CR23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.biochem.73.011303.074118","volume":"73","author":"ES Johnson","year":"2004","unstructured":"Johnson ES (2004) Protein modification by SUMO. Annu Rev Biochem 73:355\u2013382","journal-title":"Annu Rev Biochem"},{"key":"11_CR24","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/jnr.23565","volume":"93","author":"N Kaur","year":"2015","unstructured":"Kaur N, Dhiman M, Perez-Polo JR et al (2015) Ginkgolide B revamps neuroprotective role of apurinic\/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against A\u03b225\u201335-induced neurotoxicity in human neuroblastoma cells. J Neurosci Res 93:938\u2013947","journal-title":"J Neurosci Res"},{"key":"11_CR25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ptr.2331","volume":"22","author":"L Kri\u017ekov\u00e1","year":"2008","unstructured":"Kri\u017ekov\u00e1 L, Chovanov\u00e1 Z, \u010eura\u010dkov\u00e1 Z et al (2008) Antimutagenic in vitro activity of plant polyphenols: Pycnogenol\u00ae and Ginkgo biloba extract (EGb 761). Phytother Res 22:384\u2013388","journal-title":"Phytother Res"},{"key":"11_CR26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1515\/bmc-2012-0053","volume":"4","author":"J Kukucka","year":"2013","unstructured":"Kukucka J, Wyllie T, Read J et al (2013) Human neuronal cells: epigenetic aspects. Biomol Concepts 4:319\u2013333","journal-title":"Biomol Concepts"},{"key":"11_CR27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2217\/epi.10.43","volume":"2","author":"JBJ Kwok","year":"2010","unstructured":"Kwok JBJ (2010) Role of epigenetics in Alzheimer\u2019s and Parkinson\u2019s disease. Epigenomics 2:671\u2013682","journal-title":"Epigenomics"},{"key":"11_CR28","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1038\/srep07190","volume":"4","author":"L Lee","year":"2014","unstructured":"Lee L, Dale E, Staniszewski A et al (2014) Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer\u2019s disease. Sci Report 4:7190","journal-title":"Sci Report"},{"key":"11_CR29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/toxsci\/kfu037","volume":"139","author":"H Lin","year":"2014","unstructured":"Lin H, Guo X, Zhang S et al (2014) Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells. Toxicol Sci 139:338\u2013349","journal-title":"Toxicol Sci"},{"key":"11_CR30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/cvr\/cvn192","volume":"80","author":"T-J Liu","year":"2008","unstructured":"Liu T-J, Yeh Y-C, Ting C-T et al (2008) Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes. Cardiovasc Res 80:227\u2013235","journal-title":"Cardiovasc Res"},{"key":"11_CR31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbrc.2010.10.061","volume":"402","author":"W-B Liu","year":"2010","unstructured":"Liu W-B, Ao L, Zhou Z-Y et al (2010) CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Biochem Biophys Res Commun 402:507\u2013514","journal-title":"Biochem Biophys Res Commun"},{"key":"11_CR32","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.freeradbiomed.2006.08.015","volume":"41","author":"F Longpr\u00e9","year":"2006","unstructured":"Longpr\u00e9 F, Garneau P, Christen Y et al (2006) Protection by EGb 761 against \u03b2-amyloid-induced neurotoxicity: involvement of NF-\u03baB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med 41:1781\u20131794","journal-title":"Free Radic Biol Med"},{"key":"11_CR33","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.fct.2011.03.020","volume":"49","author":"F Marques","year":"2011","unstructured":"Marques F, Azevedo F, Johansson B et al (2011) Stimulation of DNA repair in Saccharomyces cerevisiae by Ginkgo biloba leaf extract. Food Chem Toxicol 49:1361\u20131366","journal-title":"Food Chem Toxicol"},{"key":"11_CR34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.expneurol.2012.10.007","volume":"239","author":"R Medeiros","year":"2013","unstructured":"Medeiros R, LaFerla FM (2013) Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp Neurol 239:133\u2013138","journal-title":"Exp Neurol"},{"key":"11_CR35","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/j.fct.2009.07.033","volume":"47","author":"K Min","year":"2009","unstructured":"Min K, Ebeler SE (2009) Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells. Food Chem Toxicol 47:2716\u20132722","journal-title":"Food Chem Toxicol"},{"key":"11_CR36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12565-015-0297-7","volume":"91","author":"NMS Osman","year":"2016","unstructured":"Osman NMS, Amer AS, Abdelwahab S (2016) Effects of Ginkgo biloba leaf extract on the neurogenesis of the hippocampal dentate gyrus in the elderly mice. Anat Sci Int 91:280\u2013289","journal-title":"Anat Sci Int"},{"key":"11_CR37","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.4161\/epi.32088","volume":"9","author":"A Poleshko","year":"2014","unstructured":"Poleshko A, Kossenkov AV, Shalginskikh N et al (2014) Human factors and pathways essential for mediating epigenetic gene silencing. Epigenetics 9:1280\u20131289","journal-title":"Epigenetics"},{"key":"11_CR38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/01635581.2011.523503","volume":"63","author":"RV Priyadarsini","year":"2011","unstructured":"Priyadarsini RV, Vinothini G, Murugan RS et al (2011) The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr Cancer 63:218\u2013226","journal-title":"Nutr Cancer"},{"key":"11_CR39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbr.2016.06.029","volume":"313","author":"ML Ribeiro","year":"2016","unstructured":"Ribeiro ML, Moreira LM, Ar\u00e7ari DP et al (2016) Protective effects of chronic treatment with a standardized extract of Ginkgo biloba L. in the prefrontal cortex and dorsal hippocampus of middle-aged rats. Behav Brain Res 313:144\u2013150","journal-title":"Behav Brain Res"},{"key":"11_CR40","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1073\/pnas.0907935106","volume":"106","author":"MA Rivieccio","year":"2009","unstructured":"Rivieccio MA, Brochier C, Willis DE et al (2009) HDAC6 is a target for protection and regeneration following injury in the nervous system. PNAS 106:19599\u201319604","journal-title":"PNAS"},{"key":"11_CR41","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2174\/138920208785699580","volume":"9","author":"B Sadikovic","year":"2008","unstructured":"Sadikovic B, Al-Romaih K, Squire JA et al (2008) Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics 9:394\u2013408","journal-title":"Curr Genomics"},{"key":"11_CR42","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s007020170016","volume":"108","author":"K Schindowski","year":"2001","unstructured":"Schindowski K, Leutner S, Kressmann S et al (2001) Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761). J Neural Transm 108:969\u2013978","journal-title":"J Neural Transm"},{"key":"11_CR43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ijms11010107","volume":"11","author":"C Shi","year":"2010","unstructured":"Shi C, Liu J, Wu F et al (2010) Ginkgo biloba extract in Alzheimer\u2019s disease: from action mechanisms to medical practice. Int J Mol Sci 11:107\u2013123","journal-title":"Int J Mol Sci"},{"key":"11_CR44","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.4161\/cc.10.18.17436","volume":"10","author":"MH Stindt","year":"2011","unstructured":"Stindt MH, Carter SA, Vigneron AM et al (2011) MDM2 promotes SUMO-2\/3 modification of p53 to modulate transcriptional activity. Cell Cycle 10:3176\u20133188","journal-title":"Cell Cycle"},{"key":"11_CR45","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-151105","volume":"52","author":"A Tramutola","year":"2016","unstructured":"Tramutola A, Pupo G, Di Domenico F et al (2016) Activation of p53 in Down syndrome and in the Ts65Dn mouse brain is associated with a pro-apoptotic phenotype. J Alzheimers Dis 52:359\u2013371","journal-title":"J Alzheimers Dis"},{"key":"11_CR46","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s40262-013-0074-5","volume":"52","author":"C Ude","year":"2013","unstructured":"Ude C, Schubert-Zsilavecz M, Wurglics M (2013) Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients. Clin Pharmacokinet 52:727\u2013749","journal-title":"Clin Pharmacokinet"},{"key":"11_CR47","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1139\/bcb-2014-0022","volume":"92","author":"JE Vargas","year":"2014","unstructured":"Vargas JE, Filippi-Chiela EC, Suhre T et al (2014) Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells. Biochem Cell Biol 92:297\u2013304","journal-title":"Biochem Cell Biol"},{"key":"11_CR48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(01)00527-X","volume":"107","author":"H Vaziri","year":"2001","unstructured":"Vaziri H, Dessain SK, Eaton EN et al (2001) hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107:149\u2013159","journal-title":"Cell"},{"key":"11_CR49","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4238\/vol8-1gmr519","volume":"8","author":"JB Vilar","year":"2009","unstructured":"Vilar JB, Leite KR, Chen LC (2009) Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow. Genet Mol Res 8:328\u2013333","journal-title":"Genet Mol Res"},{"key":"11_CR50","first-page":"154","volume-title":"WHO monographs on selected medicinal plants","author":"World Health Organization","year":"1999","unstructured":"World Health Organization (1999) WHO monographs on selected medicinal plants, vol 1. World Health Organization, Geneva, pp 154\u2013167"},{"key":"11_CR51","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1142\/S0192415X1550024X","volume":"43","author":"L-Y Wu","year":"2015","unstructured":"Wu L-Y, Lu H-F, Chou Y-C et al (2015) Kaempferol induces DNA damage and inhibits DNA repair associated protein expressions in human promyelocytic leukemia HL-60 cells. Am J Chin Med 43:365\u2013382","journal-title":"Am J Chin Med"},{"key":"11_CR52","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(04)00060-7","volume":"13","author":"SH Yang","year":"2004","unstructured":"Yang SH, Sharrocks AD (2004) SUMO promotes HDAC-mediated transcriptional repression. Mol Cell 13:611\u2013617","journal-title":"Mol Cell"},{"key":"11_CR53","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","volume":"23","author":"F Yeung","year":"2004","unstructured":"Yeung F, Hoberg JE, Ramsey CS et al (2004) Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23:2369\u20132380","journal-title":"EMBO J"},{"key":"11_CR54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainresbull.2011.11.002","volume":"87","author":"Z Zhang","year":"2012","unstructured":"Zhang Z, Peng D, Zhu H et al (2012) Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats. Brain Res Bull 87:193\u2013198","journal-title":"Brain Res Bull"},{"key":"11_CR55","doi-asserted-by":"crossref","first-page":"14633","DOI":"10.1038\/srep14633","volume":"5","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Chen S, Mei H et al (2015) Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Sci Report 5:14633","journal-title":"Sci Report"}],"container-title":["Handbook of Nutrition, Diet, and Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-55530-0_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T11:35:39Z","timestamp":1573644939000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-55530-0_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783319555294","9783319555300"],"references-count":56,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-55530-0_11","relation":{},"subject":[],"published":{"date-parts":[[2019]]}}}