{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:49:29Z","timestamp":1740098969643,"version":"3.37.3"},"publisher-location":"Cham","reference-count":129,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319605128"},{"type":"electronic","value":"9783319605135"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-60513-5_8","type":"book-chapter","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T08:14:27Z","timestamp":1509351267000},"page":"295-330","source":"Crossref","is-referenced-by-count":0,"title":["Blood and Cancer"],"prefix":"10.1007","author":[{"given":"Antonio","family":"Fasano","sequence":"first","affiliation":[]},{"given":"Ad\u00e9lia","family":"Sequeira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"volume-title":"A Survey of Models for Tumor-Immune System Dynamics","year":"1997","key":"8_CR1","unstructured":"J.A. Adam, N. Bellomo (eds.), A Survey of Models for Tumor-Immune System Dynamics (MSSET Birkh\u00e4user, Boston, 1997)"},{"issue":"1","key":"8_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/mt.2011.272","volume":"20","author":"Z. Agur","year":"2012","unstructured":"Z. Agur, S. Vuk-Pavlovi, Mathematical modeling in immunotherapy of cancer: personalizing clinical trials. Mol. Ther. 20(1), 1\u20132 (2012)","journal-title":"Mol. Ther."},{"issue":"1","key":"8_CR3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s002850100115","volume":"44","author":"Z. Agur","year":"2002","unstructured":"Z. Agur, Y. Daniel, Y. Ginosar, The universal properties of stem cells as pinpointed by a simple discrete model. J. Math. Biol. 44(1), 79\u201386 (2002)","journal-title":"J. Math. Biol."},{"key":"8_CR4","doi-asserted-by":"crossref","unstructured":"Z. Agur, M. Elishmereni, Y. Kogan, Y. Kheifetz, I. Ziv, M. Shoham, V. Vainstein, Mathematical modeling as a new approach for improving the efficacy\/toxicity profile of drugs: the thrombocytopenia case study, in Preclinical Development Handbook: ADME and Biopharmaceutical Properties, ed. by S.C. Gad, chap. 36 (Wiley, New York, 2008)","DOI":"10.1002\/9780470249031.ch36"},{"key":"8_CR5","doi-asserted-by":"crossref","unstructured":"W.C. Aird, Discovery of the cardiovascular system: from Galen to William Harvey. J. Thromb. Haemost. 9(Suppl. s1), 118\u2013129 (2011)","DOI":"10.1111\/j.1538-7836.2011.04312.x"},{"key":"8_CR6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1196\/annals.1349.016","volume":"1044","author":"K. Akashi","year":"2005","unstructured":"K. Akashi, Lineage promiscuity and plasticity in hematopoietic development. Ann. N. Y. Acad. Sci. 1044, 125\u2013131 (2005)","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"8_CR7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4236\/ajcm.2012.21002","volume":"2","author":"S. Balamuralitharan","year":"2012","unstructured":"S. Balamuralitharan, S. Rajasekaran, A parameter estimation model of G-CSF: mathematical model of cyclical neutropenia. Am. J. Comput. Math. 2, 12\u201320 (2012)","journal-title":"Am. J. Comput. Math."},{"key":"8_CR8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/197452a0","volume":"197","author":"A.J. Becker","year":"1963","unstructured":"A.J. Becker, E. McCulloch, J. Till, Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197, 452\u2013454 (1963)","journal-title":"Nature"},{"key":"8_CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/imammb\/18.2.193","volume":"18","author":"J. B\u00e9lair","year":"2001","unstructured":"J. B\u00e9lair, J.M. Mahaffy, Variable maturation velocity and parameter sensitivity in a model of haematopoiesis. IMA J. Math. Appl. Med. Biol. 18, 193\u2013211 (2001)","journal-title":"IMA J. Math. Appl. Med. Biol."},{"key":"8_CR10","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1142\/S0218202504003799","volume":"14","author":"N. Bellomo","year":"2004","unstructured":"N. Bellomo, A. Bellouquid, M. Delitala, Mathematical topics on the modelling complex multicellular systems and tumor immune cells competition. Math. Models Methods Appl. Sci. 14, 1683\u20131733 (2004)","journal-title":"Math. Models Methods Appl. Sci."},{"key":"8_CR11","unstructured":"J.H. Bennett, Leucocythemia (1845). Clinical Lectures on the Principles and Practice of Medicine, Last Edinburgh edn., (S. Samuel & W. Wood, New York, 1860), pp. 814\u20131844"},{"key":"8_CR12","doi-asserted-by":"crossref","unstructured":"J.M. Bennett, D. Catovsky, M.T. Daniel, et al., Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group. J. Clin. Pathol. 42(6), 567\u2013584 (1989)","DOI":"10.1136\/jcp.42.6.567"},{"key":"8_CR13","first-page":"145","volume-title":"New Challenges for Cancer Systems Biomedicine","author":"E. Beretta","year":"2013","unstructured":"E. Beretta, V. Capasso, A. Harel-Bellan, N. Morozova, Some results on the population behavior of cancer stem cells, in New Challenges for Cancer Systems Biomedicine, ed. by A. D\u2019Onofrio, P. Cerrai, A. Gandolfi (Springer, Berlin, 2013), pp. 145\u2013172"},{"key":"8_CR14","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.mcm.2008.07.023","volume":"49","author":"N. Bessonov","year":"2009","unstructured":"N. Bessonov, I. Demin, L. Pujo-Menjouet, V. Volpert, A multi-agent model describing self-renewal of differentiation effects on the blood cell population. Math. Comput. Model. 49, 2116\u20132127 (2009)","journal-title":"Math. Comput. Model."},{"key":"8_CR15","first-page":"885","volume":"6","author":"G. Bizzozero","year":"1868","unstructured":"G. Bizzozero, Sulla funzione ematopoetica del midollo delle ossa. Zentralbl. Med. Wiss. 6, 885 (1868)","journal-title":"Zentralbl. Med. Wiss."},{"key":"8_CR16","first-page":"149","volume":"10","author":"G. Bizzozero","year":"1869","unstructured":"G. Bizzozero, Sulla funzione ematopoetica del midollo delle ossa, seconda comunicazione preventiva. Zentralbl. Med. Wiss. 10, 149\u2013150 (1869)","journal-title":"Zentralbl. Med. Wiss."},{"key":"8_CR17","first-page":"59","volume":"34","author":"I. Borsi","year":"2015","unstructured":"I. Borsi, A. Fasano, M. Primicerio, T. Hillen, Mathematical properties of a non-local integro-PDE model for cancer stem cells. Math. Med. Biol. 34, 59\u201375 (2015)","journal-title":"Math. Med. Biol."},{"key":"8_CR18","volume-title":"A History of Transplantation Immunology","author":"L. Brent","year":"1997","unstructured":"L. Brent, A History of Transplantation Immunology (Academic Press, London, 1997)"},{"issue":"19","key":"8_CR19","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1182\/blood-2011-01-293050","volume":"117","author":"E. Campo","year":"2011","unstructured":"E. Campo, S.H. Swerdlow, N.L. Harris, S. Pileri, H. Stein, E.S. Jaffe, The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 117(19), 5019\u20135032 (2011)","journal-title":"Blood"},{"key":"8_CR20","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1158\/0008-5472.CAN-06-0241","volume":"66","author":"A. Cappuccio","year":"2006","unstructured":"A. Cappuccio, M. Elishmereni, Z. Agur, Cancer immunotherapy by Interleukin-21: potential treatment strategies evaluated in a mathematical model. Cancer Res. 66, 7293\u20137300 (2006)","journal-title":"Cancer Res."},{"key":"8_CR21","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","volume":"352","author":"N. Chiorazzi","year":"2015","unstructured":"N. Chiorazzi, K.R. Rai, M. Ferrarini, Chronic lymphocytic leukemia. N. Engl. J. Med. 352, 804\u2013815 (2015)","journal-title":"N. Engl. J. Med."},{"key":"8_CR22","first-page":"117","volume":"237","author":"C. Colijn","year":"2005","unstructured":"C. Colijn, M.C. Mackey, A mathematical model of hematopoiesis - I. Periodic chronic myelogenous leukemia. J. Theor. Biol. 237, 117\u2013132 (2005)","journal-title":"Periodic chronic myelogenous leukemia. J. Theor. Biol."},{"key":"8_CR23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jtbi.2005.03.034","volume":"237","author":"C. Colijn","year":"2005","unstructured":"C. Colijn, M.C. Mackey, A mathematical model of hematopoiesis - II. Cyclical neutropenia. J. Theor. Biol. 237, 133\u2013146 (2005)","journal-title":"Cyclical neutropenia. J. Theor. Biol."},{"key":"8_CR24","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.exphem.2007.02.015","volume":"35","author":"C. Colijn","year":"2007","unstructured":"C. Colijn, C. Foley, M.C. Mackey, G-CSF treatment of canine cyclical neutropenia: a comprehensive mathematical model. Exp. Hematol. 35, 898\u2013907 (2007)","journal-title":"Exp. Hematol."},{"key":"8_CR25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-4419-7725-0_2","volume-title":"Mathematical Models and Immune Cell Biology, Chap. 2","author":"D. Coombs","year":"2011","unstructured":"D. Coombs, O. Dushek, P.A. van der Merwe, A review of mathematical models for T cell receptor triggering and antigen discrimination, in Mathematical Models and Immune Cell Biology, Chap. 2, ed. by C. Molina-Par\u00eds, G. Lythe, (Springer, New York, 2011), pp. 25\u201345"},{"key":"8_CR26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jtbi.2005.02.015","volume":"236","author":"R. DeConde","year":"2005","unstructured":"R. DeConde, P.S. Kim, D. Levy, P.P. Lee, Post-transplantation dynamics of the immune response to chronic myelogenous leukemia. J Theor. Biol. 236, 9\u201359 (2005)","journal-title":"J Theor. Biol."},{"key":"8_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hoc.2010.11.001","volume":"25","author":"M.T. Morena de la","year":"2011","unstructured":"M.T. de la Morena, R.A. Gatti, A history of bone marrow transplantation. Hematol. Oncol. Clin. North Am. 25, 1\u201315 (2011)","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"4","key":"8_CR28","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jtbi.2005.06.037","volume":"238","author":"L.G. Pillis de","year":"2006","unstructured":"L.G. de Pillis, W. Gu, A.E. Radunskaya, Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations. J. Theor. Biol. 238(4), 841\u2013862 (2006)","journal-title":"J. Theor. Biol."},{"issue":"12","key":"8_CR29","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1634\/stemcells.2006-0136","volume":"24","author":"D. Dingli","year":"2006","unstructured":"D. Dingli, F. Michor, Successful therapy must eradicate cancer stem cells. Stem Cells 24(12), 2603\u20132610 (2006)","journal-title":"Stem Cells"},{"key":"8_CR30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/wsbm.56","volume":"2","author":"D. Dingli","year":"2010","unstructured":"D. Dingli, J.M. Pacheco, Modeling the architecture and dynamics of hematopoiesis. Wiley Interdiscip. Rev. Syst. Biol. Med. 2, 235\u2013244 (2010)","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"8_CR31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000345","volume":"2","author":"D. Dingli","year":"2007","unstructured":"D. Dingli, A. Traulsen, J.M. Pacheco, Compartmental architecture and dynamics of hematopoiesis. PLoS ONE 2, e345 (2007)","journal-title":"PLoS ONE"},{"key":"8_CR32","volume-title":"Role of Cancer Stem Cells in Cancer Biology and Therapy","author":"T. Dittmar","year":"2013","unstructured":"T. Dittmar, K.S. Z\u00e4nker, Role of Cancer Stem Cells in Cancer Biology and Therapy (CRC Press, Boca Raton, FL, 2013)"},{"key":"8_CR33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.physd.2005.06.032","volume":"208","author":"A. d\u2019Onofrio","year":"2005","unstructured":"A. d\u2019Onofrio, A general framework for modeling tumor-immune system competition and immunotherapy: mathematical analysis and biomedical inferences. Physica D 208, 220\u2013235 (2005)","journal-title":"Physica D"},{"key":"8_CR34","first-page":"249","volume-title":"New Challenges for Cancer Systems Biomedicine","author":"A. d\u2019Onofrio","year":"2013","unstructured":"A. d\u2019Onofrio, U. Ledzkevicz, H. Sch\u00e4ttler, On the dynamics of tumor-immune system interaction and combined chemo- and immunotheratpy, in New Challenges for Cancer Systems Biomedicine, ed. by A. D\u2019Onofrio, P. Cerrai, A. Gandolfi (Springer, Mailand, 2013), pp. 249\u2013266"},{"key":"8_CR35","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s11538-009-9500-0","volume":"72","author":"M. Doumic-Jauffret","year":"2010","unstructured":"M. Doumic-Jauffret, P.S. Kim, B. Perthame, Stability analysis of a simplified yet complete model for chronic myelogenous leukemia. Bull. Math. Biol. 72, 1732\u20131759 (2010)","journal-title":"Bull. Math. Biol."},{"key":"8_CR36","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","volume":"2","author":"B.J. Druker","year":"1996","unstructured":"B.J. Druker, S. Tamura, E. Buchdunger, S. Ohno, G.M. Segal, S. Fanning, J. Zimmermann, N.B. Lydon, Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2, 561\u2013566 (1996)","journal-title":"Nat. Med."},{"issue":"22","key":"8_CR37","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1158\/0008-5472.CAN-09-2115","volume":"69","author":"H. Enderling","year":"2009","unstructured":"H. Enderling, A.R.A. Anderson, M.A.J. Chaplain, A. Beheshti, L. Hlatky, P. Hahnfeldt, Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 69(22), 8814\u20138821 (2009)","journal-title":"Cancer Res."},{"key":"8_CR38","first-page":"443","volume":"4","author":"M.A. Essers","year":"2010","unstructured":"M.A. Essers, A Trumpp, Targeting leukemic stem cells by breaking their dormancy. Mol. Oncol. 4, 443\u2013450 (2010)","journal-title":"Targeting leukemic stem cells by breaking their dormancy. Mol. Oncol."},{"key":"8_CR39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mbs.2015.12.003","volume":"272","author":"A. Fasano","year":"2016","unstructured":"A. Fasano, A. Mancini, M. Primicerio. Tumours with cancer stem cells: a PDE model. Math. Biosci. 272, 76\u201380 (2016)","journal-title":"Math. Biosci."},{"key":"8_CR40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/108497802760363204","volume":"17","author":"T.M. Fliedner","year":"2002","unstructured":"T.M. Fliedner, D. Graessle, C. Paulsen, K. Reimers, Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure. Cancer Biother. Radiopharm. 17, 405\u2013426 (2002)","journal-title":"Cancer Biother. Radiopharm."},{"key":"8_CR41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00285-008-0165-3","volume":"58","author":"C. Foley","year":"2009","unstructured":"C. Foley, M.C. Mackey, Dynamic hematological disease: a review. J. Math. Biol. 58, 285\u2013322 (2009)","journal-title":"J. Math. Biol."},{"key":"8_CR42","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jtbi.2005.06.021","volume":"238","author":"C. Foley","year":"2007","unstructured":"C. Foley, S. Bernard, M.C. Mackey, Cost-effective G-CSF therapy strategies for cyclical neutropenia: mathematical modelling based hypotheses. J. Theor. Biol. 238, 754\u2013763 (2007)","journal-title":"J. Theor. Biol."},{"key":"8_CR43","doi-asserted-by":"crossref","unstructured":"J. Foo, M.W. Drummond, B. Clarkson, T. Holyoake, F. Michor, Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib. PLoS Comput. Biol. e1000503 (2009). doi:10.1371\/journal.pcbi.1000503","DOI":"10.1371\/journal.pcbi.1000503"},{"key":"8_CR44","first-page":"191","volume-title":"New Challenges for Cancer Systems Biomedicine","author":"X. Gao","year":"2013","unstructured":"X. Gao, J.T. McDonald, L. Hlatky, H. Enderling, Cell interaction in solid tumors: the role of cancer stem cells, in New Challenges for Cancer Systems Biomedicine, ed. by A. D\u2019Onofrio, P. Cerrai, A. Gandolfi (Springer, New York, 2013), pp. 191\u2013204"},{"key":"8_CR45","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/sj.bjc.6603603","volume":"96","author":"I. Glauche","year":"2007","unstructured":"I. Glauche, M. Horn, I. Roeder, Leukaemia stem cells: hit or miss? Br. J. Cancer 96, 677\u2013678 (2007)","journal-title":"Br. J. Cancer"},{"key":"8_CR46","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/bjc.2013.490","volume":"109","author":"M. Greaves","year":"2013","unstructured":"M. Greaves, Return of the malingering mutants. Br. J. Cancer 109, 1391\u20131393 (2013)","journal-title":"Br. J. Cancer"},{"key":"8_CR47","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1051\/mmnp\/20149105","volume":"9","author":"A. Halanay","year":"2014","unstructured":"A. Halanay, D. C\u00e2ndea, I.R. R\u01cedulescu, Existence and stability of limit cycles in a two-delays model of hematopoiesis including asymmetric division. Math. Model. Nat. Phenom. 9, 58\u201378 (2014)","journal-title":"Math. Model. Nat. Phenom."},{"issue":"5","key":"8_CR48","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/138920009788897975","volume":"10","author":"J.T. Hartmann","year":"2009","unstructured":"J.T. Hartmann, M. Haap, H.G. Kopp, H.P. Lipp, Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects. Curr. Drug Metab. 10(5), 470\u2013481 (2009)","journal-title":"Curr. Drug Metab."},{"key":"8_CR49","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1182\/blood.V92.8.2629","volume":"92","author":"C. Haurie","year":"1998","unstructured":"C. Haurie, D.C. Dale, M.C. Mackey, Cyclical neutropenia and other periodic hematological disorders: a review of mechanisms and mathematical models. Blood 92, 2629\u20132640 (1998)","journal-title":"Blood"},{"key":"8_CR50","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1006\/jtbi.2000.2034","volume":"204","author":"C. Haurie","year":"2000","unstructured":"C. Haurie, D.C. Dale, R. Rudnicki, M.C. Mackey, Modeling complex neutrophil dynamics in the grey collie. J. Theor. Biol. 204, 504\u2013519 (2000)","journal-title":"J. Theor. Biol."},{"issue":"3","key":"8_CR51","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","volume":"25","author":"L. Hayflick","year":"1961","unstructured":"L. Hayflick, P.S. Moorhead, The serial cultivation of human diploid cell strains. Exp. Cell Res. 25(3), 585\u2013621 (1961)","journal-title":"Exp. Cell Res."},{"key":"8_CR52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/jtbi.1997.0589","volume":"192","author":"T. Hearn","year":"1998","unstructured":"T. Hearn, C. Haurie, M.C. Mackey, Cyclical neutropenia and the peripherial control of white blood cell production. J. Theor. Biol. 192, 167\u2013181 (1998)","journal-title":"J. Theor. Biol."},{"issue":"1","key":"8_CR53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11538-012-9798-x","volume":"75","author":"T. Hillen","year":"2013","unstructured":"T. Hillen, H. Enderling, P. Hahnfeldt, The tumor growth paradox and immune system-mediated selection for cancer stem cells. Bull. Math. Biol. 75(1), 161\u2013184 (2013)","journal-title":"Bull. Math. Biol."},{"key":"8_CR54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1177\/095952873201700106","volume":"17","author":"Th. Hodgkin","year":"1832","unstructured":"Th. Hodgkin, On some morbid appearances of the absorbent glands and spleen. Med. Chir. Trans. 17, 68\u2013114 (1832)","journal-title":"Med. Chir. Trans."},{"key":"8_CR55","doi-asserted-by":"crossref","unstructured":"M. Horn, I. Glauche, M.C. M\u2019\u0301uller, R. Hehlmann, A. Hochhaus, M. Loeffler, I. Roeder, Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Blood 121(2), 378\u2013384 (2013)","DOI":"10.1182\/blood-2012-07-441956"},{"key":"8_CR56","volume-title":"Immunobiology","author":"C.A. Janeway","year":"2005","unstructured":"C.A. Janeway, P. Travers, M. Walport, M. Shlomchik, Immunobiology. 6th edn. (Garland Science, New York, 2005)","edition":"6"},{"key":"8_CR57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.leukres.2011.09.028","volume":"36","author":"K.R. Kampen","year":"2012","unstructured":"K.R. Kampen, The discovery and early understanding of leukemia. Leuk. Res. 36, 6\u201313 (2012)","journal-title":"Leuk. Res."},{"issue":"7","key":"8_CR58","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1007\/s11538-008-9336-z","volume":"70","author":"P.S. Kim","year":"2008","unstructured":"P.S. Kim, P.P. Lee, D. Levy, A PDE model for imatinib-treated chronic myelogenous leukemia. Bull. Math. Biol. 70(7), 1994\u20132016 (2008)","journal-title":"Bull. Math. Biol."},{"key":"8_CR59","doi-asserted-by":"crossref","unstructured":"P.S. Kim, P.P. Lee, D. Levy, Dynamics and potential impact of the immune response to chronic myelogenous leukemia. PLoS Comput. Biol. 4(6), e1000095 (2008). doi:10.1371\/journal.pcbi.1000095","DOI":"10.1371\/journal.pcbi.1000095"},{"issue":"2","key":"8_CR60","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/blood.V36.2.254.254","volume":"36","author":"E.A. King-Smith","year":"1970","unstructured":"E.A. King-Smith, A. Morley, Computer simulation of granulopoiesis: normal and impaired granulopoiesis. Blood 36(2), 254\u2013262 (1970)","journal-title":"Blood"},{"issue":"3","key":"8_CR61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s002850050127","volume":"37","author":"D. Kirschner","year":"1998","unstructured":"D. Kirschner, J.C. Panetta, Modeling immunotherapy of the tumor-immune interaction. J. Math. Biol. 37(3), 235\u2013252 (1998)","journal-title":"J. Math. Biol."},{"key":"8_CR62","first-page":"374","volume":"2","author":"A. K\u00f6lliker","year":"1854","unstructured":"A. K\u00f6lliker, Professors K\u00f6lliker and Bennett on the discovery of leucocythemia. Mon. J. Med. Sci. 2, 374\u2013377 (1854)","journal-title":"Mon. J. Med. Sci."},{"issue":"2","key":"8_CR63","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3934\/mbe.2011.8.289","volume":"8","author":"N.L. Komarova","year":"2011","unstructured":"N.L. Komarova, Mathematical modeling of cyclic treatments of chronic myeloid leukemia. Math. Biosci. Eng. 8(2), 289\u2013306 (2011)","journal-title":"Math. Biosci. Eng."},{"key":"8_CR64","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1073\/pnas.0501870102","volume":"102","author":"N.L. Komarova","year":"2005","unstructured":"N.L. Komarova, D. Wodarz, Drug resistance in cancer: principles of emergence and prevention. Proc. Natl. Acad. Sci. USA 102, 9714\u20139719 (2005)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"8_CR65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000057688","volume":"171","author":"M. Loeffler","year":"2002","unstructured":"M. Loeffler, I. Roeder, Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models - a conceptual approach. Cells Tissues Organs 171(1), 8\u201326 (2002)","journal-title":"Cells Tissues Organs"},{"key":"8_CR66","first-page":"401","volume-title":"Biology of the Haemopoietic Stem Cell","author":"B.L. Lord","year":"1997","unstructured":"B.L. Lord, Biology of the Haemopoietic Stem Cell (Academic Press, Cambridge, 1997), pp. 401\u2013422"},{"issue":"5","key":"8_CR67","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1182\/blood.V51.5.941.941","volume":"51","author":"M.C. Mackey","year":"1978","unstructured":"M.C. Mackey, Unified hypothesis for the origin of aplastic anemia and periodic hematopoiesis. Blood 51(5), 941\u2013956 (1978)","journal-title":"Blood"},{"key":"8_CR68","unstructured":"M.C. Mackey, Mathematical models of hematopoietic cell replication and control, in The Art of Mathematical Modelling: Case Studies in Ecology, Physiology and Biofluids ed. by H.G. Othmer, F.R. Adler, M.A. Lewis, J.C. Dallon (Prentice Hall, Upper Saddle River, 1997), pp. 149\u2013178"},{"key":"8_CR69","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1126\/science.267326","volume":"197","author":"M.C. Mackey","year":"1977","unstructured":"M.C. Mackey, L. Glass, Oscillation and chaos in physiological control systems. Science 197, 287\u2013289 (1977)","journal-title":"Science"},{"key":"8_CR70","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1073\/pnas.1317072111","volume":"111","author":"A.L. MacLean","year":"2014","unstructured":"A.L. MacLean, S. Filippi, M.P.H. Stumpf, The ecology in the hematopoietic stem cell niche determines the clinical outcome in chronic myeloid leukemia. Proc. Natl. Acad. Sci. USA 111, 3883\u20133888 (2014)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"8_CR71","unstructured":"J.M. Mahaffy, Age-structured modeling of hematopoiesis. Technical Report, Centre Recherches Mathematiques, Universit\u00e9 de Montr\u00e9al, CRM-2609 (1999)"},{"key":"8_CR72","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/jtbi.1997.0537","volume":"190","author":"J. Mahaffy","year":"1998","unstructured":"J. Mahaffy, J. B\u00e9lair, M.C. Mackey, Hematopoietic model with moving boundary condition and state dependent delay: applications in erythropoiesis. J. Theor. Biol. 190, 135\u2013146 (1998)","journal-title":"J. Theor. Biol."},{"issue":"5","key":"8_CR73","first-page":"247","volume":"7","author":"M. Mamat","year":"2013","unstructured":"M. Mamat, S. Kartono, A. Kartono. Mathematical model of cancer treatments using immunotherapy, chemotherapy and biochemotherapy. Appl. Math. Sci. 7(5), 247\u2013261 (2013)","journal-title":"Appl. Math. Sci."},{"key":"8_CR74","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/scd.2008.0143","volume":"18","author":"A. Marciniak-Czochra","year":"2009","unstructured":"A. Marciniak-Czochra, T. Stiehl, A.D. Ho, W. Jaeger, W. Wagner, Modeling of asymmetric cell division in hematopoietic stem cells - regulation of self-renewal is essential for efficient repopulation. Stem Cells Dev. 18, 377\u2013385 (2009)","journal-title":"Stem Cells Dev."},{"key":"8_CR75","doi-asserted-by":"crossref","unstructured":"A. Marciniak-Czochra, T. Stiehl, W. Wagner, Modeling of replicative senescence in hematopoietic development. Aging (Albany NY) 1(8), 723\u2013732 (2009)","DOI":"10.18632\/aging.100072"},{"key":"8_CR76","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/sj.bmt.1704226","volume":"32","author":"J. Mayer","year":"2003","unstructured":"J. Mayer, Z. Posp\u00ed\u0161il, Z. Ko\u0159\u00edstek, Mathematical model of peripheral blood stem cell harvest kinetics. Bone Marrow Transplant. 32:749\u2013757 (2003)","journal-title":"Bone Marrow Transplant."},{"key":"8_CR77","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.V73.6.1561.1561","volume":"73","author":"J.E. Menitove","year":"1989","unstructured":"J.E. Menitove, J. Pereira, R. Hoffman, T. Anderson, W. Fried, R.H. Aster, Cyclic thrombocytopenia of apparent autoimmune etiology. Blood 73, 1561\u20131569 (1989)","journal-title":"Blood"},{"key":"8_CR78","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/sj.bjc.6603604","volume":"96","author":"F. Michor","year":"2007","unstructured":"F. Michor, Reply: the long-term response to imatinib treatment of CML. Br. J. Cancer 96, 679\u2013680 (2007)","journal-title":"Br. J. Cancer"},{"key":"8_CR79","first-page":"236","volume":"23","author":"J.C. Milton","year":"1989","unstructured":"J.C. Milton, M.C. Mackey, Periodic haematological diseases: mystical entities or dynamical disorders? J. R. Coll. Physicians Lond. 23, 236\u2013241 (1989)","journal-title":"J. R. Coll. Physicians Lond."},{"key":"8_CR80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/leu.2008.246","volume":"23","author":"N. Misaghian","year":"2009","unstructured":"N. Misaghian, G. Ligresti, L.S. Steelman, F.E. Bertrand, J. B\u00e4secke, M. Libra, F. Nicoletti, F. Stivala, M. Milella, A. Tafuri, M. Cervello, A.M. Martelli, J.A. McCubre, Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia 23, 25\u201342 (2009)","journal-title":"Leukemia"},{"key":"8_CR81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026233","author":"R. Molina-Pe\u00f1a","year":"2012","unstructured":"R. Molina-Pe\u00f1a, M.M. \u00c1lvarez, A simple mathematical model based on the cancer stem cell hypothesis suggests kinetic commonalities in solid tumor growth. PLoS ONE (2012). doi:10.1371\/journal.pone.0026233","journal-title":"A simple mathematical model based on the cancer stem cell hypothesis suggests kinetic commonalities in solid tumor growth. PLoS ONE"},{"volume-title":"Mathematical Models and Immune Cell Biology","year":"2011","key":"8_CR82","unstructured":"C. Molina-Par\u00eds, G. Lythe (eds.), Mathematical Models and Immune Cell Biology (Springer, New York, 2011)"},{"key":"8_CR83","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4682-11-4","volume":"11","author":"C.L. Mouser","year":"2014","unstructured":"C.L. Mouser, E.S. Antoniou, J. Tadros, E.K. Vassiliou, A model of hematopoietic stem cell proliferation under the influence of a chemotherapeutic agent in combination with a hematopoietic inducing agent. Theor. Biol. Med. Model. 11, 4 (2014)","journal-title":"Theor. Biol. Med. Model."},{"key":"8_CR84","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1080\/17513758.2011.588343","volume":"6","author":"S. Nakaoka","year":"2012","unstructured":"S. Nakaoka, K. Aihara, Mathematical study on kinetics of hematopoietic stem cells - theoretical conditions for successful transplantation. J. Biol. Dyn. 6, 836\u2013854 (2012)","journal-title":"J. Biol. Dyn."},{"key":"8_CR85","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mbs.2007.05.003","volume":"210","author":"S. Nanda","year":"2007","unstructured":"S. Nanda, H. Moore, S. Lenhart, Optimal control of treatment in a mathematical model of chronic myelogenous leukemia. Math. Biosci. 210, 143\u2013156 (2007)","journal-title":"Math. Biosci."},{"key":"8_CR86","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3934\/dcdsb.2013.18.1053","volume":"18","author":"S. Nanda","year":"2013","unstructured":"S. Nanda, L. de Pillis, A. Radunskaya, B cell chronic lymphocytic leukemia: a model with immune response. Discrete Continuous Dyn. Syst. Ser. B 18, 1053\u20131076 (2013)","journal-title":"Discrete Continuous Dyn. Syst. Ser. B"},{"key":"8_CR87","first-page":"68","volume-title":"\u00dcber die bedeutung des knochenmarkes f\u00fcr die blutbildung","author":"E. Neumann","year":"1869","unstructured":"E. Neumann, \u00dcber die bedeutung des knochenmarkes f\u00fcr die blutbildung (Archiv der Heilkunde, Leipzig, 1869), pp. 68\u2013102"},{"key":"8_CR88","unstructured":"J.P. Okunewick, A.L. Kretchmar. A Mathematical Model for Post-irradiation Hematopoietic Recovery. Defense Technical Information Center (1967)"},{"issue":"3","key":"8_CR89","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/10428190400011625","volume":"46","author":"K.M. Page","year":"2005","unstructured":"K.M. Page, J.W. Uhr, Mathematical models of cancer dormancy. Leuk. Lymphoma 46(3), 313\u2013327 (2005)","journal-title":"Leuk. Lymphoma"},{"key":"8_CR90","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1109\/TBME.2014.2313226","volume":"61","author":"E. Pefani","year":"2014","unstructured":"E. Pefani, N. Panoskaltsis, A. Mantalaris, M.C. Georgiadis, E.N. Pistikopoulos, Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia. IEEE Trans. Biomed. Eng. 61, 2049\u20132056 (2014)","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"8_CR91","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1365-2141.2001.02411.x","volume":"112","author":"G.J. Piller","year":"2001","unstructured":"G.J. Piller, Leukaemia - a brief historical review from ancient times to 1950. Br. J. Haematol. 112, 282\u2013292 (2001)","journal-title":"Br. J. Haematol."},{"key":"8_CR92","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3109\/10428194.2013.823493","volume":"55","author":"C.A. Portell","year":"2014","unstructured":"C.A. Portell, A.S. Advani, Novel targeted therapies in acute lymphoblastic leukemia. Leuk. Lymphoma 55, 737\u2013748 (2014)","journal-title":"Leuk. Lymphoma"},{"volume-title":"Cancer Modelling and Simulation (Chapman & Hall\/CRC","year":"2003","key":"8_CR93","unstructured":"L. Preziosi (ed.), Cancer Modelling and Simulation (Chapman & Hall\/CRC, Boca Raton, FL, 2003)"},{"key":"8_CR94","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.crvi.2003.05.004","volume":"327","author":"L. Pujo-Menjouet","year":"2004","unstructured":"L. Pujo-Menjouet, M.C. Mackey, Contribution to the study of periodic chronic myelogenous leukemia. C. R. Biol. 327, 235\u2013244 (2004)","journal-title":"C. R. Biol."},{"key":"8_CR95","doi-asserted-by":"crossref","unstructured":"J. Qiu, D. Papatsenko, X- Niu, C. Schaniel, K. Moore, Divisional history and hematopoietic stem cell function during homeostasis. Stem Cell Rep. 2, 473\u2013490 (2014)","DOI":"10.1016\/j.stemcr.2014.01.016"},{"key":"8_CR96","first-page":"267","volume-title":"New Challenges for Cancer Systems Biomedicine","author":"A. Radunskaya","year":"2013","unstructured":"A. Radunskaya, S. Hook, Modeling the kinetics of the immune response, in New Challenges for Cancer Systems Biomedicine, ed. by A. D\u2019Onofrio, P. Cerrai, A. Gandolfi (Springer, Milan, 2013), pp. 267\u2013284"},{"key":"8_CR97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1158\/0008-5472.CAN-10-2987","volume":"71","author":"V. Raia","year":"2011","unstructured":"V. Raia, M. Schilling, M. Bohm, B. Hahn, A. Kowarsch, A. Raue, C.Sticht, S. Bohl, M. Saile, P.M\u00f6ller, N. Gretz, J. Timmer, F. Theis, W.-D. Lehmann, P. Lichter, U. Klingm\u00fcller, Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets. Cancer Res. 71, 693\u2013704 (2011)","journal-title":"Cancer Res."},{"key":"8_CR98","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2007.05.013","volume":"1","author":"M. Ramalho-Santos","year":"2007","unstructured":"M. Ramalho-Santos, H. Willenbring, On the origin of the term \u201cStem Cell\u201d. Cell Stem Cell 1, 35\u201338 (2007)","journal-title":"Cell Stem Cell"},{"key":"8_CR99","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bulm.2004.06.007","volume":"67","author":"B. Ribba","year":"2005","unstructured":"B. Ribba, K. Marron, Z. Agur, T. Alarc\u00f3n, P.K. Maini, A mathematical model of doxorubicin treatment efficacy for non-Hodgkin\u2019s lymphoma: investigation of the current protocol through theoretical modelling results. Bull. Math. Biol. 67, 79\u201399 (2005)","journal-title":"Bull. Math. Biol."},{"key":"8_CR100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/01.moh.0000231418.08031.48","volume":"13","author":"I. Roeder","year":"2006","unstructured":"I. Roeder, Quantitative stem cell biology: computational studies in the hematopoietic system. Curr. Opin. Hematol. 13, 222\u2013228 (2006)","journal-title":"Curr. Opin. Hematol."},{"key":"8_CR101","doi-asserted-by":"crossref","unstructured":"I. Roeder, I. Glauche, Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1. J. Theor. Biol. 241(4), 852\u2013865 (2006)","DOI":"10.1016\/j.jtbi.2006.01.021"},{"key":"8_CR102","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0301-472X(02)00832-9","volume":"30","author":"I. Roeder","year":"2002","unstructured":"I. Roeder, M. Loeffler, A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity. Exp. Hematol. 30, 853\u2013861 (2002)","journal-title":"Exp. Hematol."},{"key":"8_CR103","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nm1487","volume":"12","author":"I. Roeder","year":"2006","unstructured":"I. Roeder, M. Horn, I. Glauche, A. Hochhaus, M.C. Mueller, M. Loeffler, Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat. Med. 12, 1181\u20131184 (2006)","journal-title":"Nat. Med."},{"issue":"3","key":"8_CR104","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s11538-008-9373-7","volume":"71","author":"I. Roeder","year":"2009","unstructured":"I. Roeder, M. Herberg, M. Horn, An \u201cage\u201d-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia. Bull. Math. Biol. 71(3), 602\u2013626 (2009)","journal-title":"Bull. Math. Biol."},{"key":"8_CR105","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1056\/NEJM199510193331606","volume":"333","author":"C. Rozman","year":"1995","unstructured":"C. Rozman, E. Montserrat, Chronic lymphocytic leukemia. N. Engl. J. Med. 333, 1052\u20131057 (1995)","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"8_CR106","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5114\/wo.2013.33778","volume":"17","author":"A. Safarishahrbijari","year":"2013","unstructured":"A. Safarishahrbijari, A. Gaffari, Parameter identification of hematopoiesis mathematical model \u2013 periodic chronic myelogenous leukemia. Wspolczesna Onkol. 17(1), 73\u201377 (2013)","journal-title":"Wspolczesna Onkol."},{"key":"8_CR107","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1006\/jtbi.2000.2149","volume":"206","author":"M. Santill\u00e1n","year":"2000","unstructured":"M. Santill\u00e1n, J.M. Mahaffy, J. B\u00e9lair, M.C. Mackey, Regulation of platelet production: the normal response to perturbation and cyclical platelet disease. J. Theor. Biol. 206, 585\u2013603 (2000)","journal-title":"J. Theor. Biol."},{"key":"8_CR108","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jtbi.2009.12.032","volume":"264","author":"M. Scholz","year":"2010","unstructured":"M. Scholz, A. Gross, M. Loeffler, A biomathematical model of human thrombopoiesis under chemotherapy. J. Theor. Biol. 264, 287\u2013300 (2010)","journal-title":"J. Theor. Biol."},{"issue":"7","key":"8_CR109","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3109\/10428194.2013.842984","volume":"55","author":"M. Sekimizu","year":"2014","unstructured":"M. Sekimizu, Y. Yamashita, H. Ueki, N. Akita, H. Hattori, N. Maeda, K. Horibe, Nilotinib monotherapy induced complete remission in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to imatinib and dasatinib. Leuk. Lymphoma 55(7), 1652\u20131653 (2014)","journal-title":"Leuk. Lymphoma"},{"key":"8_CR110","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3934\/mbe.2011.8.643","volume":"8","author":"A.S. Silva","year":"2011","unstructured":"A.S. Silva, A.R.A. Anderson, R.A. Gatenby, A multiscale model of the bone marrow and hematopoiesis. Math. Biosci. Eng. 8, 643\u2013658 (2011)","journal-title":"Math. Biosci. Eng."},{"key":"8_CR111","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1051\/mmnp\/20127199","volume":"7","author":"T. Stiehl","year":"2012","unstructured":"T. Stiehl, A. Marciniak-Czochra, Mathematical modeling of leukemogenesis and cancer stem cell dynamics. Math. Model. Nat. Phenom. 7, 166\u2013202 (2012)","journal-title":"Math. Model. Nat. Phenom."},{"key":"8_CR112","doi-asserted-by":"crossref","first-page":"20140079","DOI":"10.1098\/rsif.2014.0079","volume":"11","author":"T. Stiehl","year":"2014","unstructured":"T. Stiehl, N. Baran, A.D. Ho, A. Marciniak-Czochra, Clonal selection and therapy resistance in acute leukaemias: mathematical modelling explains different proliferation patterns at diagnosis and relapse. J. R. Soc. Interface 11, 20140079 (2014). http:\/\/dx.doi.org\/10.1098\/rsif.2014.0079","journal-title":"J. R. Soc. Interface"},{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2008","key":"8_CR113","unstructured":"S.H. Swerdlow, E. Campo, N.L. Harris et al. (eds). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (IARC, Lyon, 2008)"},{"key":"8_CR114","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"H. Swerdlow","year":"2016","unstructured":"H. Swerdlow, E. Campo, S.A. Pileri, N. Lee Harris, H. Stein, R. Siebert, R. Advani, M. Ghielmini, G.A. Salles, D. Zelenetz, E.S. Jaffe, The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood 127, 2375\u20132390 (2016). doi:10.1182\/blood-2016-01-643569","journal-title":"Blood"},{"key":"8_CR115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2051-1426-1-13","volume":"1","author":"R.M. Teague","year":"2013","unstructured":"R.M. Teague, J. Kline, Immune evasion in acute myeloid leukemia: current concepts and future directions. J. Immuno-Therapy Cancer 1, 13 (2013)","journal-title":"J. Immuno-Therapy Cancer"},{"issue":"3","key":"8_CR116","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5315\/wjh.v2.i3.62","volume":"2","author":"X. Thomas","year":"2013","unstructured":"X. Thomas, First contributors in the history of leukemia. World J. Hematol. 2(3), 62\u201370 (2013)","journal-title":"World J. Hematol."},{"key":"8_CR117","first-page":"377","volume":"50","author":"A.L. Thorburn","year":"1974","unstructured":"A.L. Thorburn, Alfred Francois Donn\u00e9, 1801\u20131878, discoverer of Trichomonas vaginalis and of leukaemia. Br. J. Vener. Dis. 50, 377\u2013380 (1974)","journal-title":"Br. J. Vener. Dis."},{"key":"8_CR118","doi-asserted-by":"crossref","unstructured":"T. Tian, K. Smith-Miles, Mathematical modeling of GATA-switching for regulating the differentiation of hematopoietic stem cells. BMC Syst. Biol. 8(Suppl 1), S8 (2014)","DOI":"10.1186\/1752-0509-8-S1-S8"},{"key":"8_CR119","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2307\/3570892","volume":"14","author":"J. Till","year":"1961","unstructured":"J. Till, E. McCulloch, A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14, 213\u2013222 (1961)","journal-title":"Radiat. Res."},{"key":"8_CR120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1051\/mmnp:2008003","volume":"1","author":"V. Vainstein","year":"2006","unstructured":"V. Vainstein, Y. Ginosar, M. Shoham, A. Ianovski, A. Rabinovich, Y. Kogan,, V. Selitser, Z. Agur, Improving cancer therapy by doxorubicin and granulocyte colony-stimulating factor: insights from a computerized model of human granulopoiesis. Math. Model. Nat. Phenom. 1, 70\u201380 (2006)","journal-title":"Math. Model. Nat. Phenom."},{"key":"8_CR121","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","volume":"114","author":"J.W. Vardiman","year":"2009","unstructured":"J.W. Vardiman, J. Thiele, D.A. Arber, R.D. Brunning, M.J. Borowitz, A. Porwit, N.L. Harris, M.M. Le Beau, E. Hellstrom-Lindberg, A. Tefferi, C.D. Bloomfield, The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 114, 937\u2013951 (2009)","journal-title":"Blood"},{"key":"8_CR122","first-page":"661","volume":"52","author":"H. Vaziri","year":"1993","unstructured":"H. Vaziri, F. Schachter, I. Uchida, L. Wei X. Zhu, R. Effros, D. Cohen, C.B. Harley, Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52, 661\u2013667 (1993)","journal-title":"Am. J. Hum. Genet."},{"key":"8_CR123","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1073\/pnas.91.21.9857","volume":"91","author":"H. Vaziri","year":"1994","unstructured":"H. Vaziri, W. Dragowska, R.C. Allsopp, T.E. Thomas, C.B. Harley, P.M. Lansorp, Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA 91, 9857\u20139850 (1994)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"8_CR124","first-page":"149","volume-title":"Weisses Blut (1845), Gesammelte Abhandlungen zur Wissenschaftlichen Medicin","author":"R.L.K. Virchow","year":"1856","unstructured":"R.L.K. Virchow, Weisses Blut (1845), Gesammelte Abhandlungen zur Wissenschaftlichen Medicin (Meidinger Sohn, Frankfurt, 1856), pp. 149\u2013154"},{"key":"8_CR125","first-page":"190","volume-title":"Leuk\u00e4mie, Gesammelte Abhandlungen zur wissenschaftlichen medicin","author":"R.L.K. Virchow","year":"1856","unstructured":"R.L.K. Virchow, Leuk\u00e4mie, Gesammelte Abhandlungen zur wissenschaftlichen medicin (Meidinger Sohn, Frankfurt, 1856), pp. 190\u2013212"},{"key":"8_CR126","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/A:1024866504538","volume":"41","author":"S. Viswanathan","year":"2003","unstructured":"S. Viswanathan, P.W. Zandstra, Towards predictive models of stem cell fate. Cytotechnology 41, 75\u201392 (2003)","journal-title":"Cytotechnology"},{"key":"8_CR127","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003599","volume":"10","author":"T. Walenda","year":"2014","unstructured":"T. Walenda, T. Stiehl, H. Braun, J. Fr\u00f6bel, A.D. Ho, T. Schroeder, T.W. Goecke, B. Rath, U. Germing, A. Marciniak-Czochra, W. Wagner, Feedback signals in myelodysplastic syndromes: increased self-renewal of the malignant clone suppresses normal hematopoiesis. PLoS Comput. Biol. 10, e1003599 (2014)","journal-title":"PLoS Comput. Biol."},{"issue":"9","key":"8_CR128","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tcb.2005.07.004","volume":"15","author":"J.C. Wang","year":"2005","unstructured":"J.C. Wang, J.E. Dick, Cancer stem cells: lessons from leukemia. Trends Cell Biol. 15(9), 494\u2013501 (2005)","journal-title":"Trends Cell Biol."},{"key":"8_CR129","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1182\/blood.V43.3.379.379","volume":"43","author":"T.E. Wheldon","year":"1974","unstructured":"T.E. Wheldon, J. Kirk, H.M. Finlay, Cyclical granulopoiesis in chronic granulocytic leukemia: a simulation study. Blood 43, 379\u2013387 (1974)","journal-title":"Blood"}],"container-title":["MS&A","Hemomath"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-60513-5_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T19:40:44Z","timestamp":1603222844000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-60513-5_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319605128","9783319605135"],"references-count":129,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-60513-5_8","relation":{},"ISSN":["2037-5255","2037-5263"],"issn-type":[{"type":"print","value":"2037-5255"},{"type":"electronic","value":"2037-5263"}],"subject":[],"published":{"date-parts":[[2017]]}}}