{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:26:14Z","timestamp":1765887974892,"version":"3.41.0"},"publisher-location":"Cham","reference-count":414,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319733432"},{"type":"electronic","value":"9783319733449"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-73344-9_20","type":"book-chapter","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T08:23:22Z","timestamp":1521620602000},"page":"423-490","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection"],"prefix":"10.1007","author":[{"given":"Filomena S. G.","family":"Silva","sequence":"first","affiliation":[]},{"given":"Cl\u00e1udio F.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Ricardo J.","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo C.","family":"Pereira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"issue":"1","key":"20_CR1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jss.2009.12.007","volume":"164","author":"AM Abarbanell","year":"2010","unstructured":"Abarbanell AM (2010) Structure and lipophilicity\u2014the keys to understanding the function of pyruvate derivatives for ischemia\/reperfusion? J Surg Res 164(1):72\u201373. https:\/\/doi.org\/10.1016\/j.jss.2009.12.007","journal-title":"J Surg Res"},{"issue":"3","key":"20_CR2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0022-3565(24)39002-0","volume":"295","author":"RM Abreu","year":"2000","unstructured":"Abreu RM, Santos DJ, Moreno AJ (2000) Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress. J Pharmacol Exp Ther 295(3):1022\u20131030","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"20_CR3","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/nm1119","volume":"10","author":"T Adachi","year":"2004","unstructured":"Adachi T, Weisbrod RM, Pimentel DR, Ying J, Sharov VS, Schoneich C, Cohen RA (2004) S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med 10(11):1200\u20131207. https:\/\/doi.org\/10.1038\/nm1119","journal-title":"Nat Med"},{"issue":"29","key":"20_CR4","doi-asserted-by":"publisher","first-page":"10580","DOI":"10.1073\/pnas.1401591111","volume":"111","author":"KN Alavian","year":"2014","unstructured":"Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA Jr, Jonas EA (2014) An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Proc Natl Acad Sci U S A 111(29):10580\u201310585. https:\/\/doi.org\/10.1073\/pnas.1401591111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"20_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/sj.onc.1210600","volume":"27","author":"S Alcala","year":"2008","unstructured":"Alcala S, Klee M, Fernandez J, Fleischer A, Pimentel-Muinos FX (2008) A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release. Oncogene 27(1):44\u201354. https:\/\/doi.org\/10.1038\/sj.onc.1210600","journal-title":"Oncogene"},{"issue":"3","key":"20_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/FJC.0b013e3181831337","volume":"52","author":"M Aldakkak","year":"2008","unstructured":"Aldakkak M, Stowe DF, Heisner JS, Spence M, Camara AK (2008) Enhanced Na+\/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. J Cardiovasc Pharmacol 52(3):236\u2013244. https:\/\/doi.org\/10.1097\/FJC.0b013e3181831337","journal-title":"J Cardiovasc Pharmacol"},{"key":"20_CR7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fphys.2013.00152","volume":"4","author":"BV Alvarez","year":"2013","unstructured":"Alvarez BV, Villa-Abrille MC (2013) Mitochondrial NHE1: a newly identified target to prevent heart disease. Front Physiol 4:152. https:\/\/doi.org\/10.3389\/fphys.2013.00152","journal-title":"Front Physiol"},{"key":"20_CR8","doi-asserted-by":"publisher","first-page":"179057","DOI":"10.1155\/2011\/179057","volume":"2011","author":"P Amin","year":"2011","unstructured":"Amin P, Singh M, Singh K (2011) Beta-adrenergic receptor-stimulated cardiac myocyte apoptosis: role of beta1 integrins. J Signal Transduct 2011:179057. https:\/\/doi.org\/10.1155\/2011\/179057","journal-title":"J Signal Transduct"},{"key":"20_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2017.06.016","volume":"110","author":"TN Andrienko","year":"2017","unstructured":"Andrienko TN, Pasdois P, Pereira GC, Ovens MJ, Halestrap AP (2017) The role of succinate and ROS in reperfusion injury\u00a0\u2013 a critical appraisal. J Mol Cell Cardiol 110:1\u201314. https:\/\/doi.org\/10.1016\/j.yjmcc.2017.06.016","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"20_CR10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0021-9258(17)36131-8","volume":"261","author":"RR Anholt","year":"1986","unstructured":"Anholt RR, Pedersen PL, De Souza EB, Snyder SH (1986) The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem 261(2):576\u2013583","journal-title":"J Biol Chem"},{"issue":"8","key":"20_CR11","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1089\/ars.2014.5952","volume":"22","author":"N Apostolova","year":"2015","unstructured":"Apostolova N, Victor VM (2015) Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal 22(8):686\u2013729. https:\/\/doi.org\/10.1089\/ars.2014.5952","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"20_CR12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1432-1033.1982.tb05859.x","volume":"122","author":"H Aquila","year":"1982","unstructured":"Aquila H, Klingenberg M (1982) The reactivity of -SH groups in the ADP\/ATP carrier isolated from beef heart mitochondria. Eur J Biochem 122(1):141\u2013145","journal-title":"Eur J Biochem"},{"issue":"4","key":"20_CR13","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.molcel.2017.07.019","volume":"67","author":"DM Arduino","year":"2017","unstructured":"Arduino DM, Wettmarshausen J, Vais H, Navas-Navarro P, Cheng Y, Leimpek A, Ma Z, Delrio-Lorenzo A, Giordano A, Garcia-Perez C, Medard G, Kuster B, Garcia-Sancho J, Mokranjac D, Foskett JK, Alonso MT, Perocchi F (2017) Systematic identification of MCU modulators by orthogonal interspecies chemical screening. Mol Cell 67(4):711\u2013723. e717. https:\/\/doi.org\/10.1016\/j.molcel.2017.07.019","journal-title":"Mol Cell"},{"issue":"1","key":"20_CR14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cardiores.2003.11.003","volume":"61","author":"L Argaud","year":"2004","unstructured":"Argaud L, Gateau-Roesch O, Chalabreysse L, Gomez L, Loufouat J, Thivolet-Bejui F, Robert D, Ovize M (2004) Preconditioning delays Ca2+-induced mitochondrial permeability transition. Cardiovasc Res 61(1):115\u2013122","journal-title":"Cardiovasc Res"},{"issue":"2","key":"20_CR15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.yjmcc.2004.12.001","volume":"38","author":"L Argaud","year":"2005","unstructured":"Argaud L, Gateau-Roesch O, Muntean D, Chalabreysse L, Loufouat J, Robert D, Ovize M (2005) Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J Mol Cell Cardiol 38(2):367\u2013374. https:\/\/doi.org\/10.1016\/j.yjmcc.2004.12.001","journal-title":"J Mol Cell Cardiol"},{"issue":"3 Pt 2","key":"20_CR16","first-page":"H887","volume":"263","author":"GK Asimakis","year":"1992","unstructured":"Asimakis GK, Inners-McBride K, Medellin G, Conti VR (1992) Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat heart. Am J Phys 263(3 Pt 2):H887\u2013H894","journal-title":"Am J Phys"},{"issue":"2","key":"20_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/eurheartj\/ehu331","volume":"36","author":"D Atar","year":"2015","unstructured":"Atar D, Arheden H, Berdeaux A, Bonnet JL, Carlsson M, Clemmensen P, Cuvier V, Danchin N, Dubois-Rande JL, Engblom H, Erlinge D, Firat H, Halvorsen S, Hansen HS, Hauke W, Heiberg E, Koul S, Larsen AI, Le Corvoisier P, Nordrehaug JE, Paganelli F, Pruss RM, Rousseau H, Schaller S, Sonou G, Tuseth V, Veys J, Vicaut E, Jensen SE (2015) Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results. Eur Heart J 36(2):112\u2013119. https:\/\/doi.org\/10.1093\/eurheartj\/ehu331","journal-title":"Eur Heart J"},{"issue":"1","key":"20_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ceca.2006.11.004","volume":"42","author":"T Azarashvili","year":"2007","unstructured":"Azarashvili T, Grachev D, Krestinina O, Evtodienko Y, Yurkov I, Papadopoulos V, Reiser G (2007) The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. Cell Calcium 42(1):27\u201339. https:\/\/doi.org\/10.1016\/j.ceca.2006.11.004","journal-title":"Cell Calcium"},{"issue":"2","key":"20_CR19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ceca.2013.12.002","volume":"55","author":"T Azarashvili","year":"2014","unstructured":"Azarashvili T, Odinokova I, Bakunts A, Ternovsky V, Krestinina O, Tyynela J, Saris NE (2014) Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening. Cell Calcium 55(2):69\u201377. https:\/\/doi.org\/10.1016\/j.ceca.2013.12.002","journal-title":"Cell Calcium"},{"issue":"Pt 2","key":"20_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/BJ20031465","volume":"377","author":"H Azoulay-Zohar","year":"2004","unstructured":"Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V (2004) In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 377(Pt 2):347\u2013355. https:\/\/doi.org\/10.1042\/BJ20031465","journal-title":"Biochem J"},{"issue":"2","key":"20_CR21","doi-asserted-by":"publisher","first-page":"H903","DOI":"10.1152\/ajpheart.00575.2007","volume":"293","author":"CP Baines","year":"2007","unstructured":"Baines CP (2007) The mitochondrial permeability transition pore as a target of cardioprotective signaling. Am J Physiol Heart Circ Physiol 293(2):H903\u2013H904. https:\/\/doi.org\/10.1152\/ajpheart.00575.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7033","key":"20_CR22","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nature03434","volume":"434","author":"CP Baines","year":"2005","unstructured":"Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434(7033):658\u2013662. https:\/\/doi.org\/10.1038\/nature03434","journal-title":"Nature"},{"issue":"5","key":"20_CR23","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/ncb1575","volume":"9","author":"CP Baines","year":"2007","unstructured":"Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD (2007) Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9(5):550\u2013555. https:\/\/doi.org\/10.1038\/ncb1575","journal-title":"Nat Cell Biol"},{"issue":"19","key":"20_CR24","doi-asserted-by":"publisher","first-page":"18558","DOI":"10.1074\/jbc.C500089200","volume":"280","author":"E Basso","year":"2005","unstructured":"Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P (2005) Properties of the permeability transition pore in mitochondria devoid of cyclophilin D. J Biol Chem 280(19):18558\u201318561. https:\/\/doi.org\/10.1074\/jbc.C500089200","journal-title":"J Biol Chem"},{"issue":"5","key":"20_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.mito.2012.12.002","volume":"13","author":"S Benfeito","year":"2013","unstructured":"Benfeito S, Oliveira C, Soares P, Fernandes C, Silva T, Teixeira J, Borges F (2013) Antioxidant therapy: still in search of the \u2018magic bullet\u2019. Mitochondrion 13(5):427\u2013435. https:\/\/doi.org\/10.1016\/j.mito.2012.12.002","journal-title":"Mitochondrion"},{"issue":"5","key":"20_CR26","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/eurjhf\/hfr002","volume":"13","author":"MW Bergmann","year":"2011","unstructured":"Bergmann MW, Haufe S, von Knobelsdorff-Brenkenhoff F, Mehling H, Wassmuth R, Munch I, Busjahn A, Schulz-Menger J, Jordan J, Luft FC, Dietz R (2011) A pilot study of chronic, low-dose epoetin-{beta} following percutaneous coronary intervention suggests safety, feasibility, and efficacy in patients with symptomatic ischaemic heart failure. Eur J Heart Fail 13(5):560\u2013568. https:\/\/doi.org\/10.1093\/eurjhf\/hfr002","journal-title":"Eur J Heart Fail"},{"issue":"13","key":"20_CR27","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1016\/S0021-9258(19)50355-6","volume":"267","author":"P Bernardi","year":"1992","unstructured":"Bernardi P (1992) Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization. J Biol Chem 267(13):8834\u20138839","journal-title":"J Biol Chem"},{"key":"20_CR28","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fphys.2013.00095","volume":"4","author":"P Bernardi","year":"2013","unstructured":"Bernardi P (2013) The mitochondrial permeability transition pore: a mystery solved? Front Physiol 4:95. https:\/\/doi.org\/10.3389\/fphys.2013.00095","journal-title":"Front Physiol"},{"issue":"5","key":"20_CR29","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1016\/S0021-9258(19)50676-7","volume":"267","author":"P Bernardi","year":"1992","unstructured":"Bernardi P, Vassanelli S, Veronese P, Colonna R, Szabo I, Zoratti M (1992) Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. J Biol Chem 267(5):2934\u20132939","journal-title":"J Biol Chem"},{"issue":"4","key":"20_CR30","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1152\/physrev.00001.2015","volume":"95","author":"P Bernardi","year":"2015","unstructured":"Bernardi P, Rasola A, Forte M, Lippe G (2015) The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology. Physiol Rev 95(4):1111\u20131155. https:\/\/doi.org\/10.1152\/physrev.00001.2015","journal-title":"Physiol Rev"},{"key":"20_CR31","doi-asserted-by":"publisher","first-page":"e345","DOI":"10.1038\/cddis.2012.84","volume":"3","author":"Y Bhagatte","year":"2012","unstructured":"Bhagatte Y, Lodwick D, Storey N (2012) Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes. Cell Death Dis 3:e345. https:\/\/doi.org\/10.1038\/cddis.2012.84","journal-title":"Cell Death Dis"},{"issue":"3","key":"20_CR32","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s00395-007-0691-y","volume":"103","author":"GS Bhamra","year":"2008","unstructured":"Bhamra GS, Hausenloy DJ, Davidson SM, Carr RD, Paiva M, Wynne AM, Mocanu MM, Yellon DM (2008) Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening. Basic Res Cardiol 103(3):274\u2013284. https:\/\/doi.org\/10.1007\/s00395-007-0691-y","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"20_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/cdd.2015.96","volume":"23","author":"TG Biel","year":"2016","unstructured":"Biel TG, Lee S, Flores-Toro JA, Dean JW, Go KL, Lee MH, Law BK, Law ME, Dunn WA Jr, Zendejas I, Behrns KE, Kim JS (2016) Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner. Cell Death Differ 23(2):279\u2013290. https:\/\/doi.org\/10.1038\/cdd.2015.96","journal-title":"Cell Death Differ"},{"key":"20_CR34","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.yjmcc.2015.03.017","volume":"84","author":"T Bochaton","year":"2015","unstructured":"Bochaton T, Crola-Da-Silva C, Pillot B, Villedieu C, Ferreras L, Alam MR, Thibault H, Strina M, Gharib A, Ovize M, Baetz D (2015) Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D. J Mol Cell Cardiol 84:61\u201369. https:\/\/doi.org\/10.1016\/j.yjmcc.2015.03.017","journal-title":"J Mol Cell Cardiol"},{"issue":"5","key":"20_CR35","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1089\/ars.2010.3309","volume":"14","author":"K Boengler","year":"2011","unstructured":"Boengler K, Heusch G, Schulz R (2011) Mitochondria in postconditioning. Antioxid Redox Signal 14(5):863\u2013880. https:\/\/doi.org\/10.1089\/ars.2010.3309","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"20_CR36","doi-asserted-by":"publisher","first-page":"674","DOI":"10.4161\/cc.23599","volume":"12","author":"M Bonora","year":"2013","unstructured":"Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, Wieckowski MR, Kroemer G, Galluzzi L, Pinton P (2013) Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12(4):674\u2013683. https:\/\/doi.org\/10.4161\/cc.23599","journal-title":"Cell Cycle"},{"issue":"7","key":"20_CR37","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.15252\/embr.201643602","volume":"18","author":"M Bonora","year":"2017","unstructured":"Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G, Wieckowski MR, Galluzzi L, Pinton P (2017) Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Rep 18(7):1077\u20131089. https:\/\/doi.org\/10.15252\/embr.201643602","journal-title":"EMBO Rep"},{"issue":"2","key":"20_CR38","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0022-5223(03)00209-5","volume":"126","author":"SW Boyce","year":"2003","unstructured":"Boyce SW, Bartels C, Bolli R, Chaitman B, Chen JC, Chi E, Jessel A, Kereiakes D, Knight J, Thulin L, Theroux P, Investigators GDIANS (2003) Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study. J Thorac Cardiovasc Surg 126(2):420\u2013427","journal-title":"J Thorac Cardiovasc Surg"},{"key":"20_CR39","doi-asserted-by":"publisher","first-page":"37798","DOI":"10.1038\/srep37798","volume":"6","author":"T Briston","year":"2016","unstructured":"Briston T, Lewis S, Koglin M, Mistry K, Shen Y, Hartopp N, Katsumata R, Fukumoto H, Duchen MR, Szabadkai G, Staddon JM, Roberts M, Powney B (2016) Identification of ER-000444793, a cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep 6:37798. https:\/\/doi.org\/10.1038\/srep37798","journal-title":"Sci Rep"},{"issue":"1","key":"20_CR40","doi-asserted-by":"publisher","first-page":"10492","DOI":"10.1038\/s41598-017-10673-8","volume":"7","author":"T Briston","year":"2017","unstructured":"Briston T, Roberts M, Lewis S, Powney B, Staddon MJ, Szabadkai G (2017) Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability. Sci Rep 7(1):10492. https:\/\/doi.org\/10.1038\/s41598-017-10673-8","journal-title":"Sci Rep"},{"issue":"27","key":"20_CR41","doi-asserted-by":"publisher","first-page":"20474","DOI":"10.1074\/jbc.M001077200","volume":"275","author":"PS Brookes","year":"2000","unstructured":"Brookes PS, Salinas EP, Darley-Usmar K, Eiserich JP, Freeman BA, Darley-Usmar VM, Anderson PG (2000) Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J Biol Chem 275(27):20474\u201320479. https:\/\/doi.org\/10.1074\/jbc.M001077200","journal-title":"J Biol Chem"},{"issue":"1","key":"20_CR42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/cvr\/cvn053","volume":"79","author":"DA Brown","year":"2008","unstructured":"Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O'Rourke B (2008) Effects of 4\u2032-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. Cardiovasc Res 79(1):141\u2013149. https:\/\/doi.org\/10.1093\/cvr\/cvn053","journal-title":"Cardiovasc Res"},{"issue":"1","key":"20_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/cvr\/cvq154","volume":"88","author":"GR Budas","year":"2010","unstructured":"Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D (2010) Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. Cardiovasc Res 88(1):83\u201392. https:\/\/doi.org\/10.1093\/cvr\/cvq154","journal-title":"Cardiovasc Res"},{"issue":"3","key":"20_CR44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1054\/ceca.1999.0027","volume":"25","author":"AE Bugrim","year":"1999","unstructured":"Bugrim AE (1999) Regulation of Ca2+ release by cAMP-dependent protein kinase. A mechanism for agonist-specific calcium signaling? Cell Calcium 25(3):219\u2013226. https:\/\/doi.org\/10.1054\/ceca.1999.0027","journal-title":"Cell Calcium"},{"issue":"1","key":"20_CR45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1432-1033.1989.tb14637.x","volume":"180","author":"R Bunger","year":"1989","unstructured":"Bunger R, Mallet RT, Hartman DA (1989) Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure. Eur J Biochem 180(1):221\u2013233","journal-title":"Eur J Biochem"},{"issue":"36","key":"20_CR46","doi-asserted-by":"publisher","first-page":"12446","DOI":"10.1523\/JNEUROSCI.1641-15.2015","volume":"35","author":"E Caballero-Garrido","year":"2015","unstructured":"Caballero-Garrido E, Pena-Philippides JC, Lordkipanidze T, Bragin D, Yang Y, Erhardt EB, Roitbak T (2015) In vivo inhibition of miR-155 promotes recovery after experimental mouse stroke. J Neurosci 35(36):12446\u201312464. https:\/\/doi.org\/10.1523\/JNEUROSCI.1641-15.2015","journal-title":"J Neurosci"},{"issue":"1","key":"20_CR47","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nbt1044","volume":"23","author":"S Cabantous","year":"2005","unstructured":"Cabantous S, Terwilliger TC, Waldo GS (2005) Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein. Nat Biotechnol 23(1):102\u2013107. https:\/\/doi.org\/10.1038\/nbt1044","journal-title":"Nat Biotechnol"},{"issue":"3","key":"20_CR48","doi-asserted-by":"publisher","first-page":"696","DOI":"10.2337\/db07-1098","volume":"57","author":"JW Calvert","year":"2008","unstructured":"Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann WH, Tian R, Lefer DJ (2008) Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling. Diabetes 57(3):696\u2013705. https:\/\/doi.org\/10.2337\/db07-1098","journal-title":"Diabetes"},{"issue":"3","key":"20_CR49","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1089\/ars.2009.2788","volume":"13","author":"AK Camara","year":"2010","unstructured":"Camara AK, Lesnefsky EJ, Stowe DF (2010) Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal 13(3):279\u2013347. https:\/\/doi.org\/10.1089\/ars.2009.2788","journal-title":"Antioxid Redox Signal"},{"key":"20_CR50","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3389\/fphys.2017.00460","volume":"8","author":"AKS Camara","year":"2017","unstructured":"Camara AKS, Zhou Y, Wen PC, Tajkhorshid E, Kwok WM (2017) Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target. Front Physiol 8:460. https:\/\/doi.org\/10.3389\/fphys.2017.00460","journal-title":"Front Physiol"},{"key":"20_CR51","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.ijcard.2016.07.125","volume":"221","author":"G Campo","year":"2016","unstructured":"Campo G, Morciano G, Pavasini R, Bonora M, Sbano L, Biscaglia S, Bovolenta M, Pinotti M, Punzetti S, Rizzo P, Aquila G, Giorgi C, Ferrari R, Pinton P (2016) Fo ATP synthase C subunit serum levels in patients with ST-segment elevation myocardial infarction: preliminary findings. Int J Cardiol 221:993\u2013997. https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.125","journal-title":"Int J Cardiol"},{"issue":"23","key":"20_CR52","doi-asserted-by":"publisher","first-page":"15980","DOI":"10.1074\/jbc.C114.559633","volume":"289","author":"M Carraro","year":"2014","unstructured":"Carraro M, Giorgio V, Sileikyte J, Sartori G, Forte M, Lippe G, Zoratti M, Szabo I, Bernardi P (2014) Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transition. J Biol Chem 289(23):15980\u201315985. https:\/\/doi.org\/10.1074\/jbc.C114.559633","journal-title":"J Biol Chem"},{"issue":"4","key":"20_CR53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/187152906779010746","volume":"6","author":"RS Carreira","year":"2006","unstructured":"Carreira RS, Monteiro P, Gon Alves LM, Providencia LA (2006) Carvedilol: just another Beta-blocker or a powerful cardioprotector? Cardiovasc Hematol Disord Drug Targets 6(4):257\u2013266","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"issue":"20","key":"20_CR54","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2174\/138161211796904777","volume":"17","author":"RS Carreira","year":"2011","unstructured":"Carreira RS, Lee P, Gottlieb RA (2011) Mitochondrial therapeutics for cardioprotection. Curr Pharm Des 17(20):2017\u20132035","journal-title":"Curr Pharm Des"},{"issue":"6","key":"20_CR55","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02110442","volume":"28","author":"RF Castilho","year":"1996","unstructured":"Castilho RF, Kowaltowski AJ, Vercesi AE (1996) The irreversibility of inner mitochondrial membrane permeabilization by Ca2+ plus prooxidants is determined by the extent of membrane protein thiol cross-linking. J Bioenerg Biomembr 28(6):523\u2013529","journal-title":"J Bioenerg Biomembr"},{"issue":"2","key":"20_CR56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0022-2828(90)91111-J","volume":"22","author":"L Cavallini","year":"1990","unstructured":"Cavallini L, Valente M, Rigobello MP (1990) The protective action of pyruvate on recovery of ischemic rat heart: comparison with other oxidizable substrates. J Mol Cell Cardiol 22(2):143\u2013154","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"20_CR57","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/eurheartj\/eht420","volume":"35","author":"G Cerisano","year":"2014","unstructured":"Cerisano G, Buonamici P, Valenti R, Sciagra R, Raspanti S, Santini A, Carrabba N, Dovellini EV, Romito R, Pupi A, Colonna P, Antoniucci D (2014) Early short-term doxycycline therapy in patients with acute myocardial infarction and left ventricular dysfunction to prevent the ominous progression to adverse remodelling: the TIPTOP trial. Eur Heart J 35(3):184\u2013191. https:\/\/doi.org\/10.1093\/eurheartj\/eht420","journal-title":"Eur Heart J"},{"issue":"6","key":"20_CR58","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0006-2952(00)00588-8","volume":"61","author":"B Chelli","year":"2001","unstructured":"Chelli B, Falleni A, Salvetti F, Gremigni V, Lucacchini A, Martini C (2001) Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue. Biochem Pharmacol 61(6):695\u2013705","journal-title":"Biochem Pharmacol"},{"issue":"22","key":"20_CR59","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1016\/j.jacc.2012.07.056","volume":"60","author":"HH Chen","year":"2012","unstructured":"Chen HH, Glockner JF, Schirger JA, Cataliotti A, Redfield MM, Burnett JC Jr (2012) Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide. J Am Coll Cardiol 60(22):2305\u20132312. https:\/\/doi.org\/10.1016\/j.jacc.2012.07.056","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"20_CR60","doi-asserted-by":"publisher","first-page":"H424","DOI":"10.1152\/ajpheart.00454.2014","volume":"308","author":"T Chen","year":"2015","unstructured":"Chen T, Li J, Liu J, Li N, Wang S, Liu H, Zeng M, Zhang Y, Bu P (2015) Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-beta\/Smad3 pathway. Am J Physiol Heart Circ Physiol 308(5):H424\u2013H434. https:\/\/doi.org\/10.1152\/ajpheart.00454.2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"20_CR61","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.febslet.2010.12.008","volume":"585","author":"Q Cheng","year":"2011","unstructured":"Cheng Q, Sedlic F, Pravdic D, Bosnjak ZJ, Kwok WM (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585(2):328\u2013334. https:\/\/doi.org\/10.1016\/j.febslet.2010.12.008","journal-title":"FEBS Lett"},{"issue":"6","key":"20_CR62","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2165\/11636090-000000000-00000","volume":"12","author":"C Chen-Scarabelli","year":"2012","unstructured":"Chen-Scarabelli C, Saravolatz L Jr, Murad Y, Shieh WS, Qureshi W, Di Rezze J, Abrencillo R, Gardin T, Gidwani UK, Saravolatz L, Faggian G, Scarabelli TM (2012) A critical review of the use of carvedilol in ischemic heart disease. Am J Cardiovasc Drugs 12(6):391\u2013401. https:\/\/doi.org\/10.2165\/11636090-000000000-00000","journal-title":"Am J Cardiovasc Drugs"},{"issue":"2","key":"20_CR63","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1097\/ALN.0000000000000331","volume":"121","author":"P Chiari","year":"2014","unstructured":"Chiari P, Angoulvant D, Mewton N, Desebbe O, Obadia JF, Robin J, Farhat F, Jegaden O, Bastien O, Lehot JJ, Ovize M (2014) Cyclosporine protects the heart during aortic valve surgery. Anesthesiology 121(2):232\u2013238. https:\/\/doi.org\/10.1097\/ALN.0000000000000331","journal-title":"Anesthesiology"},{"key":"20_CR64","doi-asserted-by":"publisher","unstructured":"Chinopoulos C (2017) Mitochondrial permeability transition pore: back to the drawing board. Neurochem Int. https:\/\/doi.org\/10.1016\/j.neuint.2017.06.010","DOI":"10.1016\/j.neuint.2017.06.010"},{"key":"20_CR65","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fonc.2014.00235","volume":"4","author":"C Chinopoulos","year":"2014","unstructured":"Chinopoulos C, Szabadkai G (2014) What makes you can also break you, part III: mitochondrial permeability transition pore formation by an uncoupling channel within the C-subunit ring of the F1FO ATP synthase? Front Oncol 4:235. https:\/\/doi.org\/10.3389\/fonc.2014.00235","journal-title":"Front Oncol"},{"issue":"7527","key":"20_CR66","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E, Aksentijevic D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515(7527):431\u2013435. https:\/\/doi.org\/10.1038\/nature13909","journal-title":"Nature"},{"issue":"38","key":"20_CR67","doi-asserted-by":"publisher","first-page":"34793","DOI":"10.1074\/jbc.M202191200","volume":"277","author":"SJ Clarke","year":"2002","unstructured":"Clarke SJ, McStay GP, Halestrap AP (2002) Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A. J Biol Chem 277(38):34793\u201334799. https:\/\/doi.org\/10.1074\/jbc.M202191200","journal-title":"J Biol Chem"},{"issue":"9","key":"20_CR68","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1161\/CIRCRESAHA.107.167072","volume":"102","author":"SJ Clarke","year":"2008","unstructured":"Clarke SJ, Khaliulin I, Das M, Parker JE, Heesom KJ, Halestrap AP (2008) Inhibition of mitochondrial permeability transition pore opening by ischemic preconditioning is probably mediated by reduction of oxidative stress rather than mitochondrial protein phosphorylation. Circ Res 102(9):1082\u20131090. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.167072","journal-title":"Circ Res"},{"issue":"6","key":"20_CR69","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.bmcl.2006.12.102","volume":"17","author":"J Cleary","year":"2007","unstructured":"Cleary J, Johnson KM, Opipari AW Jr, Glick GD (2007) Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor. Bioorg Med Chem Lett 17(6):1667\u20131670. https:\/\/doi.org\/10.1016\/j.bmcl.2006.12.102","journal-title":"Bioorg Med Chem Lett"},{"issue":"6","key":"20_CR70","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nrd1415","volume":"3","author":"P Cohen","year":"2004","unstructured":"Cohen P, Goedert M (2004) GSK3 inhibitors: development and therapeutic potential. Nat Rev Drug Discov 3(6):479\u2013487. https:\/\/doi.org\/10.1038\/nrd1415","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"20_CR71","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0003-2697(84)90016-2","volume":"139","author":"G Constantopoulos","year":"1984","unstructured":"Constantopoulos G, Barranger JA (1984) Nonenzymatic decarboxylation of pyruvate. Anal Biochem 139(2):353\u2013358","journal-title":"Anal Biochem"},{"issue":"2","key":"20_CR72","doi-asserted-by":"publisher","first-page":"H874","DOI":"10.1152\/ajpheart.01189.2007","volume":"295","author":"AD Costa","year":"2008","unstructured":"Costa AD, Garlid KD (2008) Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT. Am J Physiol Heart Circ Physiol 295(2):H874\u2013H882. https:\/\/doi.org\/10.1152\/ajpheart.01189.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"20_CR73","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1161\/01.RES.0000178451.08719.5b","volume":"97","author":"AD Costa","year":"2005","unstructured":"Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD (2005) Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res 97(4):329\u2013336. https:\/\/doi.org\/10.1161\/01.RES.0000178451.08719.5b","journal-title":"Circ Res"},{"issue":"30","key":"20_CR74","doi-asserted-by":"publisher","first-page":"20801","DOI":"10.1074\/jbc.M600959200","volume":"281","author":"AD Costa","year":"2006","unstructured":"Costa AD, Jakob R, Costa CL, Andrukhiv K, West IC, Garlid KD (2006) The mechanism by which the mitochondrial ATP-sensitive K+ channel opening and H2O2 inhibit the mitochondrial permeability transition. J Biol Chem 281(30):20801\u201320808. https:\/\/doi.org\/10.1074\/jbc.M600959200","journal-title":"J Biol Chem"},{"issue":"2","key":"20_CR75","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/cvr\/cvm050","volume":"77","author":"AD Costa","year":"2008","unstructured":"Costa AD, Pierre SV, Cohen MV, Downey JM, Garlid KD (2008) cGMP signalling in pre- and post-conditioning: the role of mitochondria. Cardiovasc Res 77(2):344\u2013352. https:\/\/doi.org\/10.1093\/cvr\/cvm050","journal-title":"Cardiovasc Res"},{"issue":"10","key":"20_CR76","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.embor.7401062","volume":"8","author":"JT Cribbs","year":"2007","unstructured":"Cribbs JT, Strack S (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 8(10):939\u2013944. https:\/\/doi.org\/10.1038\/sj.embor.7401062","journal-title":"EMBO Rep"},{"issue":"2","key":"20_CR77","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1432-1033.1988.tb14475.x","volume":"178","author":"M Crompton","year":"1988","unstructured":"Crompton M, Costi A (1988) Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress. A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload. Eur J Biochem 178(2):489\u2013501","journal-title":"Eur J Biochem"},{"issue":"1","key":"20_CR78","first-page":"357","volume":"255","author":"M Crompton","year":"1988","unstructured":"Crompton M, Ellinger H, Costi A (1988) Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J 255(1):357\u2013360","journal-title":"Biochem J"},{"issue":"1\u20136","key":"20_CR79","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0960-0760(99)00056-4","volume":"69","author":"M Culty","year":"1999","unstructured":"Culty M, Li H, Boujrad N, Amri H, Vidic B, Bernassau JM, Reversat JL, Papadopoulos V (1999) In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis. J Steroid Biochem Mol Biol 69(1\u20136):123\u2013130","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"11","key":"20_CR80","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1056\/NEJMoa1505489","volume":"373","author":"TT Cung","year":"2015","unstructured":"Cung TT, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guerin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit JF, Jouve B, Motreff P, Tron C, Labeque JN, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice MC, Ider O, Dubois-Rande JL, Unterseeh T, Le Breton H, Beard T, Blanchard D, Grollier G, Malquarti V, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M (2015) Cyclosporine before PCI in patients with acute myocardial infarction. N Engl J Med 373(11):1021\u20131031. https:\/\/doi.org\/10.1056\/NEJMoa1505489","journal-title":"N Engl J Med"},{"issue":"9","key":"20_CR81","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/iub.1063","volume":"64","author":"D Silva Da","year":"2012","unstructured":"Da Silva D, Ausina P, Alencar EM, Coelho WS, Zancan P, Sola-Penna M (2012) Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice. IUBMB Life 64(9):766\u2013774. https:\/\/doi.org\/10.1002\/iub.1063","journal-title":"IUBMB Life"},{"issue":"9","key":"20_CR82","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/CIRCRESAHA.108.178970","volume":"103","author":"S Das","year":"2008","unstructured":"Das S, Wong R, Rajapakse N, Murphy E, Steenbergen C (2008) Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation. Circ Res 103(9):983\u2013991. https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.178970","journal-title":"Circ Res"},{"issue":"Pt 8","key":"20_CR83","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1242\/jcs.140467","volume":"127","author":"C Datler","year":"2014","unstructured":"Datler C, Pazarentzos E, Mahul-Mellier AL, Chaisaklert W, Hwang MS, Osborne F, Grimm S (2014) CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex. J Cell Sci 127(Pt 8):1816\u20131828. https:\/\/doi.org\/10.1242\/jcs.140467","journal-title":"J Cell Sci"},{"issue":"38","key":"20_CR84","doi-asserted-by":"publisher","first-page":"15301","DOI":"10.1073\/pnas.1305462110","volume":"110","author":"B Daum","year":"2013","unstructured":"Daum B, Walter A, Horst A, Osiewacz HD, Kuhlbrandt W (2013) Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria. Proc Natl Acad Sci U S A 110(38):15301\u201315306. https:\/\/doi.org\/10.1073\/pnas.1305462110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"20_CR85","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.biocel.2005.09.017","volume":"38","author":"SM Davidson","year":"2006","unstructured":"Davidson SM, Hausenloy D, Duchen MR, Yellon DM (2006) Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. Int J Biochem Cell Biol 38(3):414\u2013419. https:\/\/doi.org\/10.1016\/j.biocel.2005.09.017","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"20_CR86","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1432-1033.1993.tb18070.x","volume":"215","author":"DV Macedo de","year":"1993","unstructured":"de Macedo DV, Nepomuceno ME, Pereira-da-Silva L (1993) Involvement of the ADP\/ATP carrier in permeabilization processes of the inner mitochondrial membrane. Eur J Biochem 215(3):595\u2013600","journal-title":"Eur J Biochem"},{"issue":"1","key":"20_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2014.03.004","volume":"56","author":"E Marchi De","year":"2014","unstructured":"De Marchi E, Bonora M, Giorgi C, Pinton P (2014) The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux. Cell Calcium 56(1):1\u201313. https:\/\/doi.org\/10.1016\/j.ceca.2014.03.004","journal-title":"Cell Calcium"},{"issue":"5","key":"20_CR88","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00395-013-0379-4","volume":"108","author":"D Paulis De","year":"2013","unstructured":"De Paulis D, Chiari P, Teixeira G, Couture-Lepetit E, Abrial M, Argaud L, Gharib A, Ovize M (2013) Cyclosporine A at reperfusion fails to reduce infarct size in the in vivo rat heart. Basic Res Cardiol 108(5):379. https:\/\/doi.org\/10.1007\/s00395-013-0379-4","journal-title":"Basic Res Cardiol"},{"issue":"5 Pt 2","key":"20_CR89","first-page":"H1571","volume":"265","author":"LW DeBoer","year":"1993","unstructured":"DeBoer LW, Bekx PA, Han L, Steinke L (1993) Pyruvate enhances recovery of rat hearts after ischemia and reperfusion by preventing free radical generation. Am J Phys 265(5 Pt 2):H1571\u2013H1576","journal-title":"Am J Phys"},{"issue":"1","key":"20_CR90","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0008-6363(99)00179-0","volume":"44","author":"LR Dekker","year":"1999","unstructured":"Dekker LR, Coronel R, VanBavel E, Spaan JA, Opthof T (1999) Intracellular Ca2+ and delay of ischemia-induced electrical uncoupling in preconditioned rabbit ventricular myocardium. Cardiovasc Res 44(1):101\u2013112","journal-title":"Cardiovasc Res"},{"issue":"2 Pt 2","key":"20_CR91","first-page":"H484","volume":"275","author":"TJ Delcamp","year":"1998","unstructured":"Delcamp TJ, Dales C, Ralenkotter L, Cole PS, Hadley RW (1998) Intramitochondrial [Ca2+] and membrane potential in ventricular myocytes exposed to anoxia-reoxygenation. Am J Phys 275(2 Pt 2):H484\u2013H494","journal-title":"Am J Phys"},{"issue":"5","key":"20_CR92","doi-asserted-by":"publisher","first-page":"e000461","DOI":"10.1161\/JAHA.113.000461","volume":"2","author":"MH Disatnik","year":"2013","unstructured":"Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D (2013) Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. J Am Heart Assoc 2(5):e000461. https:\/\/doi.org\/10.1161\/JAHA.113.000461","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"20_CR93","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1021\/acschembio.5b00753","volume":"11","author":"AS Dixon","year":"2016","unstructured":"Dixon AS, Schwinn MK, Hall MP, Zimmerman K, Otto P, Lubben TH, Butler BL, Binkowski BF, Machleidt T, Kirkland TA, Wood MG, Eggers CT, Encell LP, Wood KV (2016) NanoLuc complementation reporter optimized for accurate measurement of protein interactions in cells. ACS Chem Biol 11(2):400\u2013408. https:\/\/doi.org\/10.1021\/acschembio.5b00753","journal-title":"ACS Chem Biol"},{"issue":"5","key":"20_CR94","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00005344-199911000-00005","volume":"34","author":"P Dobsak","year":"1999","unstructured":"Dobsak P, Courderot-Masuyer C, Zeller M, Vergely C, Laubriet A, Assem M, Eicher JC, Teyssier JR, Wolf JE, Rochette L (1999) Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J Cardiovasc Pharmacol 34(5):651\u2013659","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1\u20132","key":"20_CR95","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000046878","volume":"10","author":"M Dolder","year":"2001","unstructured":"Dolder M, Wendt S, Wallimann T (2001) Mitochondrial creatine kinase in contact sites: interaction with porin and adenine nucleotide translocase, role in permeability transition and sensitivity to oxidative damage. Biol Signals Recept 10(1\u20132):93\u2013111","journal-title":"Biol Signals Recept"},{"issue":"2","key":"20_CR96","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2217\/fca.14.6","volume":"10","author":"RK Dongworth","year":"2014","unstructured":"Dongworth RK, Hall AR, Burke N, Hausenloy DJ (2014) Targeting mitochondria for cardioprotection: examining the benefit for patients. Futur Cardiol 10(2):255\u2013272. https:\/\/doi.org\/10.2217\/fca.14.6","journal-title":"Futur Cardiol"},{"issue":"2","key":"20_CR97","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1177\/1074248407300897","volume":"12","author":"J Dow","year":"2007","unstructured":"Dow J, Kloner RA (2007) Postconditioning does not reduce myocardial infarct size in an in vivo regional ischemia rodent model. J Cardiovasc Pharmacol Ther 12(2):153\u2013163. https:\/\/doi.org\/10.1177\/1074248407300897","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"3","key":"20_CR98","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1042\/BJ20111301","volume":"441","author":"H Dube","year":"2012","unstructured":"Dube H, Selwood D, Malouitre S, Capano M, Simone MI, Crompton M (2012) A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes. Biochem J 441(3):901\u2013907. https:\/\/doi.org\/10.1042\/BJ20111301","journal-title":"Biochem J"},{"issue":"3","key":"20_CR99","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00395-015-0490-9","volume":"110","author":"SU Eisenhardt","year":"2015","unstructured":"Eisenhardt SU, Weiss JB, Smolka C, Maxeiner J, Pankratz F, Bemtgen X, Kustermann M, Thiele JR, Schmidt Y, Bjoern Stark G, Moser M, Bode C, Grundmann S (2015) MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst. Basic Res Cardiol 110(3):32. https:\/\/doi.org\/10.1007\/s00395-015-0490-9","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"20_CR100","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1253\/circj.CJ-13-0321","volume":"77","author":"JW Elrod","year":"2013","unstructured":"Elrod JW, Molkentin JD (2013) Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circ J 77(5):1111\u20131122","journal-title":"Circ J"},{"issue":"6 Pt 1","key":"20_CR101","doi-asserted-by":"crossref","first-page":"C1297","DOI":"10.1152\/ajpcell.1999.276.6.C1297","volume":"276","author":"O Eriksson","year":"1999","unstructured":"Eriksson O, Pollesello P, Geimonen E (1999) Regulation of total mitochondrial Ca2+ in perfused liver is independent of the permeability transition pore. Am J Phys 276(6 Pt 1):C1297\u2013C1302","journal-title":"Am J Phys"},{"issue":"12","key":"20_CR102","doi-asserted-by":"publisher","first-page":"5333","DOI":"10.1021\/jm500547c","volume":"57","author":"D Fancelli","year":"2014","unstructured":"Fancelli D, Abate A, Amici R, Bernardi P, Ballarini M, Cappa A, Carenzi G, Colombo A, Contursi C, Di Lisa F, Dondio G, Gagliardi S, Milanesi E, Minucci S, Pain G, Pelicci PG, Saccani A, Storto M, Thaler F, Varasi M, Villa M, Plyte S (2014) Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo. J Med Chem 57(12):5333\u20135347. https:\/\/doi.org\/10.1021\/jm500547c","journal-title":"J Med Chem"},{"issue":"4","key":"20_CR103","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.carpath.2006.04.005","volume":"15","author":"JC Fantinelli","year":"2006","unstructured":"Fantinelli JC, Cingolani HE, Mosca SM (2006) Na+\/H+ exchanger inhibition at the onset of reperfusion decreases myocardial infarct size: role of reactive oxygen species. Cardiovasc Pathol 15(4):179\u2013184. https:\/\/doi.org\/10.1016\/j.carpath.2006.04.005","journal-title":"Cardiovasc Pathol"},{"issue":"5","key":"20_CR104","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/00000542-200511000-00013","volume":"103","author":"J Feng","year":"2005","unstructured":"Feng J, Lucchinetti E, Ahuja P, Pasch T, Perriard JC, Zaugg M (2005) Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta. Anesthesiology 103(5):987\u2013995","journal-title":"Anesthesiology"},{"issue":"1","key":"20_CR105","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s12012-010-9095-6","volume":"11","author":"X Feng","year":"2011","unstructured":"Feng X, Li J, Liu J, Jin M, Liu X, Du H, Zhang L, Sun Z, Li X (2011) Protective effect of FK506 on myocardial ischemia\/reperfusion injury by suppression of CaN and ASK1 signaling circuitry. Cardiovasc Toxicol 11(1):18\u201327. https:\/\/doi.org\/10.1007\/s12012-010-9095-6","journal-title":"Cardiovasc Toxicol"},{"issue":"5","key":"20_CR106","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1002\/hep.22835","volume":"49","author":"R Flisiak","year":"2009","unstructured":"Flisiak R, Feinman SV, Jablkowski M, Horban A, Kryczka W, Pawlowska M, Heathcote JE, Mazzella G, Vandelli C, Nicolas-Metral V, Grosgurin P, Liz JS, Scalfaro P, Porchet H, Crabbe R (2009) The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology 49(5):1460\u20131468. https:\/\/doi.org\/10.1002\/hep.22835","journal-title":"Hepatology"},{"issue":"4","key":"20_CR107","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00395-006-0593-4","volume":"101","author":"K Forster","year":"2006","unstructured":"Forster K, Paul I, Solenkova N, Staudt A, Cohen MV, Downey JM, Felix SB, Krieg T (2006) NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Basic Res Cardiol 101(4):319\u2013326. https:\/\/doi.org\/10.1007\/s00395-006-0593-4","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"20_CR108","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1123\/ijspp.1.4.311","volume":"1","author":"M Francaux","year":"2006","unstructured":"Francaux M, Poortmans JR (2006) Side effects of creatine supplementation in athletes. Int J Sports Physiol Perform 1(4):311\u2013323","journal-title":"Int J Sports Physiol Perform"},{"issue":"34","key":"20_CR109","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1038\/onc.2008.114","volume":"27","author":"L Galluzzi","year":"2008","unstructured":"Galluzzi L, Kepp O, Tajeddine N, Kroemer G (2008) Disruption of the hexokinase-VDAC complex for tumor therapy. Oncogene 27(34):4633\u20134635. https:\/\/doi.org\/10.1038\/onc.2008.114","journal-title":"Oncogene"},{"issue":"4","key":"20_CR110","doi-asserted-by":"publisher","first-page":"e60967","DOI":"10.1371\/journal.pone.0060967","volume":"8","author":"D Gao","year":"2013","unstructured":"Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J (2013) Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One 8(4):e60967. https:\/\/doi.org\/10.1371\/journal.pone.0060967","journal-title":"PLoS One"},{"issue":"6","key":"20_CR111","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1152\/japplphysiol.90616.2008","volume":"105","author":"CD Garciarena","year":"2008","unstructured":"Garciarena CD, Caldiz CI, Correa MV, Schinella GR, Mosca SM, Chiappe de Cingolani GE, Cingolani HE, Ennis IL (2008) Na+\/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action. J Appl Physiol (1985) 105(6):1706\u20131713. https:\/\/doi.org\/10.1152\/japplphysiol.90616.2008","journal-title":"J Appl Physiol (1985)"},{"issue":"2","key":"20_CR112","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0026-895X(25)09915-8","volume":"45","author":"M Garnier","year":"1994","unstructured":"Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA, Papadopoulos V (1994) In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol 45(2):201\u2013211","journal-title":"Mol Pharmacol"},{"issue":"12","key":"20_CR113","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.4161\/15548627.2014.991665","volume":"10","author":"J Gatliff","year":"2014","unstructured":"Gatliff J, East D, Crosby J, Abeti R, Harvey R, Craigen W, Parker P, Campanella M (2014) TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy 10(12):2279\u20132296. https:\/\/doi.org\/10.4161\/15548627.2014.991665","journal-title":"Autophagy"},{"issue":"15","key":"20_CR114","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1073\/pnas.1217823110","volume":"110","author":"V Giorgio","year":"2013","unstructured":"Giorgio V, von Stockum S, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V, Zoratti M, Szabo I, Lippe G, Bernardi P (2013) Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A 110(15):5887\u20135892. https:\/\/doi.org\/10.1073\/pnas.1217823110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"20_CR115","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.15252\/embr.201643354","volume":"18","author":"V Giorgio","year":"2017","unstructured":"Giorgio V, Burchell V, Schiavone M, Bassot C, Minervini G, Petronilli V, Argenton F, Forte M, Tosatto S, Lippe G, Bernardi P (2017) Ca2+ binding to F-ATP synthase beta subunit triggers the mitochondrial permeability transition. EMBO Rep 18(7):1065\u20131076. https:\/\/doi.org\/10.15252\/embr.201643354","journal-title":"EMBO Rep"},{"issue":"1","key":"20_CR116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2015.12.046","volume":"581","author":"S Golshani-Hebroni","year":"2016","unstructured":"Golshani-Hebroni S (2016) Mg(++) requirement for MtHK binding, and Mg(++) stabilization of mitochondrial membranes via activation of MtHK & MtCK and promotion of mitochondrial permeability transition pore closure: a hypothesis on mechanisms underlying Mg(++)\u2019s antioxidant and cytoprotective effects. Gene 581(1):1\u201313. https:\/\/doi.org\/10.1016\/j.gene.2015.12.046","journal-title":"Gene"},{"issue":"3","key":"20_CR117","doi-asserted-by":"publisher","first-page":"H1654","DOI":"10.1152\/ajpheart.01378.2006","volume":"293","author":"L Gomez","year":"2007","unstructured":"Gomez L, Thibault H, Gharib A, Dumont JM, Vuagniaux G, Scalfaro P, Derumeaux G, Ovize M (2007) Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice. Am J Physiol Heart Circ Physiol 293(3):H1654\u2013H1661. https:\/\/doi.org\/10.1152\/ajpheart.01378.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"21","key":"20_CR118","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1161\/CIRCULATIONAHA.107.755066","volume":"117","author":"L Gomez","year":"2008","unstructured":"Gomez L, Paillard M, Thibault H, Derumeaux G, Ovize M (2008) Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion. Circulation 117(21):2761\u20132768. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.755066","journal-title":"Circulation"},{"issue":"6","key":"20_CR119","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.yjmcc.2009.03.001","volume":"46","author":"EJ Griffiths","year":"2009","unstructured":"Griffiths EJ (2009) Mitochondrial calcium transport in the heart: physiological and pathological roles. J Mol Cell Cardiol 46(6):789\u2013803. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.03.001","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"20_CR120","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1006\/jmcc.1993.1162","volume":"25","author":"EJ Griffiths","year":"1993","unstructured":"Griffiths EJ, Halestrap AP (1993) Protection by cyclosporin A of ischemia\/reperfusion-induced damage in isolated rat hearts. J Mol Cell Cardiol 25(12):1461\u20131469. https:\/\/doi.org\/10.1006\/jmcc.1993.1162","journal-title":"J Mol Cell Cardiol"},{"issue":"Pt 1","key":"20_CR121","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/bj3070093","volume":"307","author":"EJ Griffiths","year":"1995","unstructured":"Griffiths EJ, Halestrap AP (1995) Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 307(Pt 1):93\u201398","journal-title":"Biochem J"},{"issue":"7","key":"20_CR122","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1161\/01.RES.0000122392.33172.09","volume":"94","author":"ER Gross","year":"2004","unstructured":"Gross ER, Hsu AK, Gross GJ (2004) Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 94(7):960\u2013966. https:\/\/doi.org\/10.1161\/01.RES.0000122392.33172.09","journal-title":"Circ Res"},{"issue":"4","key":"20_CR123","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000342981","volume":"123","author":"Group MS","year":"2012","unstructured":"Group MS (2012) Rationale and design of the \u2018MITOCARE\u2019 study: a phase II, multicenter, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of TRO40303 for the reduction of reperfusion injury in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Cardiology 123(4):201\u2013207. https:\/\/doi.org\/10.1159\/000342981","journal-title":"Cardiology"},{"issue":"5","key":"20_CR124","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/00005344-199011000-00014","volume":"16","author":"GJ Grover","year":"1990","unstructured":"Grover GJ, Dzwonczyk S, Sleph PG (1990) Ruthenium red improves postischemic contractile function in isolated rat hearts. J Cardiovasc Pharmacol 16(5):783\u2013789","journal-title":"J Cardiovasc Pharmacol"},{"issue":"4","key":"20_CR125","doi-asserted-by":"publisher","first-page":"H1747","DOI":"10.1152\/ajpheart.01019.2003","volume":"287","author":"GJ Grover","year":"2004","unstructured":"Grover GJ, Atwal KS, Sleph PG, Wang FL, Monshizadegan H, Monticello T, Green DW (2004) Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. Am J Phys Heart Circ Phys 287(4):H1747\u2013H1755. https:\/\/doi.org\/10.1152\/ajpheart.01019.2003","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"5","key":"20_CR126","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.biotechadv.2012.09.005","volume":"31","author":"J Gruber","year":"2013","unstructured":"Gruber J, Fong S, Chen CB, Yoong S, Pastorin G, Schaffer S, Cheah I, Halliwell B (2013) Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnol Adv 31(5):563\u2013592. https:\/\/doi.org\/10.1016\/j.biotechadv.2012.09.005","journal-title":"Biotechnol Adv"},{"issue":"6","key":"20_CR127","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1152\/japplphysiol.90537.2008","volume":"106","author":"E Gurel","year":"2009","unstructured":"Gurel E, Smeele KM, Eerbeek O, Koeman A, Demirci C, Hollmann MW, Zuurbier CJ (2009) Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion. J Appl Physiol (1985) 106(6):1909\u20131916. https:\/\/doi.org\/10.1152\/japplphysiol.90537.2008","journal-title":"J Appl Physiol (1985)"},{"key":"20_CR128","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.yjmcc.2014.04.008","volume":"72","author":"M Gutierrez-Aguilar","year":"2014","unstructured":"Gutierrez-Aguilar M, Douglas DL, Gibson AK, Domeier TL, Molkentin JD, Baines CP (2014) Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. J Mol Cell Cardiol 72:316\u2013325. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.04.008","journal-title":"J Mol Cell Cardiol"},{"key":"20_CR129","doi-asserted-by":"publisher","unstructured":"Gwag HB, Kim EK, Park TK, Lee JM, Yang JH, Song YB, Choi JH, Choi SH, Lee SH, Chang SA, Park SJ, Lee SC, Park SW, Jang WJ, Lee M, Chun WJ, Oh JH, Park YH, Choe YH, Gwon HC, Hahn JY (2017) Cardioprotective effects of intracoronary morphine in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a prospective, randomized trial. J Am Heart Assoc 6(4). https:\/\/doi.org\/10.1161\/JAHA.116.005426","DOI":"10.1161\/JAHA.116.005426"},{"issue":"12","key":"20_CR130","doi-asserted-by":"publisher","first-page":"914","DOI":"10.18632\/aging.100252","volume":"2","author":"AV Hafner","year":"2010","unstructured":"Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA (2010) Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) 2(12):914\u2013923. https:\/\/doi.org\/10.18632\/aging.100252","journal-title":"Aging (Albany NY)"},{"issue":"Pt 3","key":"20_CR131","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj2780715","volume":"278","author":"AP Halestrap","year":"1991","unstructured":"Halestrap AP (1991) Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage. Biochem J 278(Pt 3):715\u2013719","journal-title":"Biochem J"},{"issue":"6","key":"20_CR132","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","volume":"46","author":"AP Halestrap","year":"2009","unstructured":"Halestrap AP (2009) What is the mitochondrial permeability transition pore? J Mol Cell Cardiol 46(6):821\u2013831. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.02.021","journal-title":"J Mol Cell Cardiol"},{"key":"20_CR133","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3389\/fonc.2014.00234","volume":"4","author":"AP Halestrap","year":"2014","unstructured":"Halestrap AP (2014) The C ring of the F1Fo ATP synthase forms the mitochondrial permeability transition pore: a critical appraisal. Front Oncol 4:234. https:\/\/doi.org\/10.3389\/fonc.2014.00234","journal-title":"Front Oncol"},{"issue":"16","key":"20_CR134","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2174\/0929867033457278","volume":"10","author":"AP Halestrap","year":"2003","unstructured":"Halestrap AP, Brenner C (2003) The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem 10(16):1507\u20131525","journal-title":"Curr Med Chem"},{"issue":"1","key":"20_CR135","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj2680153","volume":"268","author":"AP Halestrap","year":"1990","unstructured":"Halestrap AP, Davidson AM (1990) Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem J 268(1):153\u2013160","journal-title":"Biochem J"},{"issue":"11","key":"20_CR136","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.bbabio.2008.12.017","volume":"1787","author":"AP Halestrap","year":"2009","unstructured":"Halestrap AP, Pasdois P (2009) The role of the mitochondrial permeability transition pore in heart disease. Biochim Biophys Acta 1787(11):1402\u20131415. https:\/\/doi.org\/10.1016\/j.bbabio.2008.12.017","journal-title":"Biochim Biophys Acta"},{"key":"20_CR137","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.yjmcc.2014.08.018","volume":"78","author":"AP Halestrap","year":"2015","unstructured":"Halestrap AP, Richardson AP (2015) The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia\/reperfusion injury. J Mol Cell Cardiol 78:129\u2013141. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.08.018","journal-title":"J Mol Cell Cardiol"},{"issue":"1\u20132","key":"20_CR138","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1006879618176","volume":"174","author":"AP Halestrap","year":"1997","unstructured":"Halestrap AP, Connern CP, Griffiths EJ, Kerr PM (1997a) Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia\/reperfusion injury. Mol Cell Biochem 174(1\u20132):167\u2013172","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"20_CR139","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1074\/jbc.272.6.3346","volume":"272","author":"AP Halestrap","year":"1997","unstructured":"Halestrap AP, Woodfield KY, Connern CP (1997b) Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem 272(6):3346\u20133354","journal-title":"J Biol Chem"},{"issue":"3","key":"20_CR140","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","volume":"61","author":"AP Halestrap","year":"2004","unstructured":"Halestrap AP, Clarke SJ, Javadov SA (2004) Mitochondrial permeability transition pore opening during myocardial reperfusion\u2014a target for cardioprotection. Cardiovasc Res 61(3):372\u2013385. https:\/\/doi.org\/10.1016\/S0008-6363(03)00533-9","journal-title":"Cardiovasc Res"},{"issue":"8","key":"20_CR141","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.bbabio.2007.05.008","volume":"1767","author":"AP Halestrap","year":"2007","unstructured":"Halestrap AP, Clarke SJ, Khaliulin I (2007) The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta 1767(8):1007\u20131031. https:\/\/doi.org\/10.1016\/j.bbabio.2007.05.008","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"20_CR142","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1111\/bph.12899","volume":"172","author":"AP Halestrap","year":"2015","unstructured":"Halestrap AP, Pereira GC, Pasdois P (2015) The role of hexokinase in cardioprotection\u00a0\u2013 mechanism and potential for translation. Br J Pharmacol 172(8):2085\u20132100. https:\/\/doi.org\/10.1111\/bph.12899","journal-title":"Br J Pharmacol"},{"key":"20_CR143","doi-asserted-by":"publisher","first-page":"e2238","DOI":"10.1038\/cddis.2016.139","volume":"7","author":"AR Hall","year":"2016","unstructured":"Hall AR, Burke N, Dongworth RK, Kalkhoran SB, Dyson A, Vicencio JM, Dorn GW II, Yellon DM, Hausenloy DJ (2016) Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction. Cell Death Dis 7:e2238. https:\/\/doi.org\/10.1038\/cddis.2016.139","journal-title":"Cell Death Dis"},{"issue":"1","key":"20_CR144","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.yjmcc.2005.04.002","volume":"39","author":"PJ Hanley","year":"2005","unstructured":"Hanley PJ, Daut J (2005) K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms. J Mol Cell Cardiol 39(1):17\u201350. https:\/\/doi.org\/10.1016\/j.yjmcc.2005.04.002","journal-title":"J Mol Cell Cardiol"},{"issue":"Pt 3","key":"20_CR145","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1113\/jphysiol.2002.023960","volume":"542","author":"PJ Hanley","year":"2002","unstructured":"Hanley PJ, Mickel M, Loffler M, Brandt U, Daut J (2002) K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol 542(Pt 3):735\u2013741","journal-title":"J Physiol"},{"issue":"4","key":"20_CR146","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1023\/B:JOBB.0000041776.31885.45","volume":"36","author":"MJ Hansson","year":"2004","unstructured":"Hansson MJ, Mattiasson G, Mansson R, Karlsson J, Keep MF, Waldmeier P, Ruegg UT, Dumont JM, Besseghir K, Elmer E (2004) The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria. J Bioenerg Biomembr 36(4):407\u2013413. https:\/\/doi.org\/10.1023\/B:JOBB.0000041776.31885.45","journal-title":"J Bioenerg Biomembr"},{"key":"20_CR147","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ejphar.2015.04.009","volume":"760","author":"MJ Hansson","year":"2015","unstructured":"Hansson MJ, Llwyd O, Morin D, de Paulis D, Arnoux T, Gouarne C, Koul S, Engblom H, Bordet T, Tissier R, Arheden H, Erlinge D, Halestrap AP, Berdeaux A, Pruss RM, Schaller S (2015) Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia\/reperfusion injury. Eur J Pharmacol 760:7\u201319. https:\/\/doi.org\/10.1016\/j.ejphar.2015.04.009","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"20_CR148","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1006\/jmcc.1999.1029","volume":"31","author":"M Hartmann","year":"1999","unstructured":"Hartmann M, Decking UK (1999) Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective. J Mol Cell Cardiol 31(11):1985\u20131995. https:\/\/doi.org\/10.1006\/jmcc.1999.1029","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"20_CR149","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1253\/circj.CJ-08-0130","volume":"72","author":"N Hata","year":"2008","unstructured":"Hata N, Seino Y, Tsutamoto T, Hiramitsu S, Kaneko N, Yoshikawa T, Yokoyama H, Tanaka K, Mizuno K, Nejima J, Kinoshita M (2008) Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study. Circ J 72(11):1787\u20131793","journal-title":"Circ J"},{"issue":"3","key":"20_CR150","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.cardiores.2003.09.024","volume":"61","author":"DJ Hausenloy","year":"2004","unstructured":"Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 61(3):448\u2013460. https:\/\/doi.org\/10.1016\/j.cardiores.2003.09.024","journal-title":"Cardiovasc Res"},{"issue":"4","key":"20_CR151","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","volume":"13","author":"DJ Hausenloy","year":"2016","unstructured":"Hausenloy DJ, Yellon DM (2016) Ischaemic conditioning and reperfusion injury. Nat Rev Cardiol 13(4):193\u2013209. https:\/\/doi.org\/10.1038\/nrcardio.2016.5","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"20_CR152","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0008-6363(02)00455-8","volume":"55","author":"DJ Hausenloy","year":"2002","unstructured":"Hausenloy DJ, Maddock HL, Baxter GF, Yellon DM (2002) Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning? Cardiovasc Res 55(3):534\u2013543","journal-title":"Cardiovasc Res"},{"issue":"3","key":"20_CR153","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cardiores.2003.09.025","volume":"60","author":"DJ Hausenloy","year":"2003","unstructured":"Hausenloy DJ, Duchen MR, Yellon DM (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res 60(3):617\u2013625","journal-title":"Cardiovasc Res"},{"issue":"2","key":"20_CR154","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.cardiores.2004.04.011","volume":"63","author":"DJ Hausenloy","year":"2004","unstructured":"Hausenloy DJ, Mocanu MM, Yellon DM (2004a) Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning. Cardiovasc Res 63(2):305\u2013312. https:\/\/doi.org\/10.1016\/j.cardiores.2004.04.011","journal-title":"Cardiovasc Res"},{"issue":"2","key":"20_CR155","doi-asserted-by":"publisher","first-page":"H841","DOI":"10.1152\/ajpheart.00678.2003","volume":"287","author":"DJ Hausenloy","year":"2004","unstructured":"Hausenloy DJ, Yellon DM, Mani-Babu S, Duchen MR (2004b) Preconditioning protects by inhibiting the mitochondrial permeability transition. Am J Physiol Heart Circ Physiol 287(2):H841\u2013H849. https:\/\/doi.org\/10.1152\/ajpheart.00678.2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"20_CR156","doi-asserted-by":"publisher","first-page":"H971","DOI":"10.1152\/ajpheart.00374.2004","volume":"288","author":"DJ Hausenloy","year":"2005","unstructured":"Hausenloy DJ, Tsang A, Mocanu MM, Yellon DM (2005a) Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 288(2):H971\u2013H976. https:\/\/doi.org\/10.1152\/ajpheart.00374.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"20_CR157","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.tcm.2005.03.001","volume":"15","author":"DJ Hausenloy","year":"2005","unstructured":"Hausenloy DJ, Tsang A, Yellon DM (2005b) The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med 15(2):69\u201375. https:\/\/doi.org\/10.1016\/j.tcm.2005.03.001","journal-title":"Trends Cardiovasc Med"},{"issue":"7","key":"20_CR158","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1136\/heartjnl-2013-304845","volume":"100","author":"D Hausenloy","year":"2014","unstructured":"Hausenloy D, Kunst G, Boston-Griffiths E, Kolvekar S, Chaubey S, John L, Desai J, Yellon D (2014) The effect of cyclosporin-A on peri-operative myocardial injury in adult patients undergoing coronary artery bypass graft surgery: a randomised controlled clinical trial. Heart 100(7):544\u2013549. https:\/\/doi.org\/10.1136\/heartjnl-2013-304845","journal-title":"Heart"},{"issue":"1","key":"20_CR159","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1005568630151","volume":"32","author":"RA Haworth","year":"2000","unstructured":"Haworth RA, Hunter DR (2000) Control of the mitochondrial permeability transition pore by high-affinity ADP binding at the ADP\/ATP translocase in permeabilized mitochondria. J Bioenerg Biomembr 32(1):91\u201396","journal-title":"J Bioenerg Biomembr"},{"issue":"1\u20133","key":"20_CR160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(01)03314-2","volume":"512","author":"L He","year":"2002","unstructured":"He L, Lemasters JJ (2002) Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett 512(1\u20133):1\u20137","journal-title":"FEBS Lett"},{"issue":"13","key":"20_CR161","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1073\/pnas.1702357114","volume":"114","author":"J He","year":"2017","unstructured":"He J, Ford HC, Carroll J, Ding S, Fearnley IM, Walker JE (2017) Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase. Proc Natl Acad Sci U S A 114(13):3409\u20133414. https:\/\/doi.org\/10.1073\/pnas.1702357114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"20_CR162","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0005-2728(97)00050-9","volume":"1321","author":"K Herick","year":"1997","unstructured":"Herick K, Kramer R, Luhring H (1997) Patch clamp investigation into the phosphate carrier from Saccharomyces cerevisiae mitochondria. Biochim Biophys Acta 1321(3):207\u2013220","journal-title":"Biochim Biophys Acta"},{"issue":"9161","key":"20_CR163","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0140-6736(98)06423-X","volume":"353","author":"HP Hermann","year":"1999","unstructured":"Hermann HP, Pieske B, Schwarzmuller E, Keul J, Just H, Hasenfuss G (1999) Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study. Lancet 353(9161):1321\u20131323","journal-title":"Lancet"},{"issue":"3 Pt 2","key":"20_CR164","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1006\/clin.1996.0140","volume":"80","author":"S Ho","year":"1996","unstructured":"Ho S, Clipstone N, Timmermann L, Northrop J, Graef I, Fiorentino D, Nourse J, Crabtree GR (1996) The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 80(3 Pt 2):S40\u2013S45","journal-title":"Clin Immunol Immunopathol"},{"issue":"4","key":"20_CR165","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1128\/MMBR.00016-08","volume":"72","author":"S Hong","year":"2008","unstructured":"Hong S, Pedersen PL (2008) ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas. Microbiol Mol Biol Rev 72(4):590\u2013641. https:\/\/doi.org\/10.1128\/MMBR.00016-08","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1\u20133","key":"20_CR166","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ejphar.2012.07.053","volume":"695","author":"L Hong","year":"2012","unstructured":"Hong L, Xi J, Zhang Y, Tian W, Xu J, Cui X, Xu Z (2012) Atrial natriuretic peptide prevents the mitochondrial permeability transition pore opening by inactivating glycogen synthase kinase 3beta via PKG and PI3K in cardiac H9c2 cells. Eur J Pharmacol 695(1\u20133):13\u201319. https:\/\/doi.org\/10.1016\/j.ejphar.2012.07.053","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"20_CR167","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1631\/jzus.B1600253","volume":"17","author":"DX Hu","year":"2016","unstructured":"Hu DX, Liu XB, Song WC, Wang JA (2016) Roles of SIRT3 in heart failure: from bench to bedside. J Zhejiang Univ Sci B 17(11):821\u2013830. https:\/\/doi.org\/10.1631\/jzus.B1600253","journal-title":"J Zhejiang Univ Sci B"},{"issue":"1","key":"20_CR168","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10863-016-9672-x","volume":"49","author":"S Hurst","year":"2017","unstructured":"Hurst S, Hoek J, Sheu SS (2017) Mitochondrial Ca2+ and regulation of the permeability transition pore. J Bioenerg Biomembr 49(1):27\u201347. https:\/\/doi.org\/10.1007\/s10863-016-9672-x","journal-title":"J Bioenerg Biomembr"},{"issue":"10","key":"20_CR169","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1006\/jmcc.2000.1222","volume":"32","author":"C Hurtado","year":"2000","unstructured":"Hurtado C, Pierce GN (2000) Inhibition of Na(+)\/H(+) exchange at the beginning of reperfusion is cardioprotective in isolated, beating adult cardiomyocytes. J Mol Cell Cardiol 32(10):1897\u20131907. https:\/\/doi.org\/10.1006\/jmcc.2000.1222","journal-title":"J Mol Cell Cardiol"},{"key":"20_CR170","doi-asserted-by":"publisher","first-page":"20467","DOI":"10.1038\/srep20467","volume":"6","author":"G Ikeda","year":"2016","unstructured":"Ikeda G, Matoba T, Nakano Y, Nagaoka K, Ishikita A, Nakano K, Funamoto D, Sunagawa K, Egashira K (2016) Nanoparticle-mediated targeting of cyclosporine A enhances cardioprotection against ischemia-reperfusion injury through inhibition of mitochondrial permeability transition pore opening. Sci Rep 6:20467. https:\/\/doi.org\/10.1038\/srep20467","journal-title":"Sci Rep"},{"issue":"18","key":"20_CR171","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1111\/bph.12638","volume":"171","author":"F Ivanes","year":"2014","unstructured":"Ivanes F, Faccenda D, Gatliff J, Ahmed AA, Cocco S, Cheng CH, Allan E, Russell C, Duchen MR, Campanella M (2014) The compound BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol 171(18):4193\u20134206. https:\/\/doi.org\/10.1111\/bph.12638","journal-title":"Br J Pharmacol"},{"issue":"6","key":"20_CR172","doi-asserted-by":"publisher","first-page":"838","DOI":"10.3349\/ymj.2010.51.6.838","volume":"51","author":"IS Jang","year":"2010","unstructured":"Jang IS, Park MY, Shin IW, Sohn JT, Lee HK, Chung YK (2010) Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia\/reperfusion injury. Yonsei Med J 51(6):838\u2013844. https:\/\/doi.org\/10.3349\/ymj.2010.51.6.838","journal-title":"Yonsei Med J"},{"issue":"1\u20134","key":"20_CR173","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000103747","volume":"20","author":"S Javadov","year":"2007","unstructured":"Javadov S, Karmazyn M (2007) Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem 20(1\u20134):1\u201322. https:\/\/doi.org\/10.1159\/000103747","journal-title":"Cell Physiol Biochem"},{"issue":"Pt 2","key":"20_CR174","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1113\/jphysiol.2003.034231","volume":"549","author":"SA Javadov","year":"2003","unstructured":"Javadov SA, Clarke S, Das M, Griffiths EJ, Lim KH, Halestrap AP (2003) Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart. J Physiol 549(Pt 2):513\u2013524. https:\/\/doi.org\/10.1113\/jphysiol.2003.034231","journal-title":"J Physiol"},{"issue":"1","key":"20_CR175","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.yjmcc.2004.10.007","volume":"38","author":"S Javadov","year":"2005","unstructured":"Javadov S, Huang C, Kirshenbaum L, Karmazyn M (2005) NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat. J Mol Cell Cardiol 38(1):135\u2013143. https:\/\/doi.org\/10.1016\/j.yjmcc.2004.10.007","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"20_CR176","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/cvr\/cvm039","volume":"77","author":"S Javadov","year":"2008","unstructured":"Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M (2008) NHE-1 inhibition-induced cardioprotection against ischaemia\/reperfusion is associated with attenuation of the mitochondrial permeability transition. Cardiovasc Res 77(2):416\u2013424. https:\/\/doi.org\/10.1093\/cvr\/cvm039","journal-title":"Cardiovasc Res"},{"issue":"3","key":"20_CR177","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1124\/jpet.109.153213","volume":"330","author":"S Javadov","year":"2009","unstructured":"Javadov S, Karmazyn M, Escobales N (2009a) Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases. J Pharmacol Exp Ther 330(3):670\u2013678. https:\/\/doi.org\/10.1124\/jpet.109.153213","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"20_CR178","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.yjmcc.2008.12.023","volume":"46","author":"S Javadov","year":"2009","unstructured":"Javadov S, Rajapurohitam V, Kilic A, Zeidan A, Choi A, Karmazyn M (2009b) Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. J Mol Cell Cardiol 46(6):998\u20131007. https:\/\/doi.org\/10.1016\/j.yjmcc.2008.12.023","journal-title":"J Mol Cell Cardiol"},{"issue":"8","key":"20_CR179","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1038\/emboj.2012.45","volume":"31","author":"S Jiang","year":"2012","unstructured":"Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, Liang S, Li B, Li Y, Li D, Wang ED, Liu MF (2012) A novel miR-155\/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J 31(8):1985\u20131998. https:\/\/doi.org\/10.1038\/emboj.2012.45","journal-title":"EMBO J"},{"issue":"7423","key":"20_CR180","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature11444","volume":"491","author":"ML Joiner","year":"2012","unstructured":"Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME (2012) CaMKII determines mitochondrial stress responses in heart. Nature 491(7423):269\u2013273. https:\/\/doi.org\/10.1038\/nature11444","journal-title":"Nature"},{"key":"20_CR181","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.phrs.2015.04.013","volume":"99","author":"EA Jonas","year":"2015","unstructured":"Jonas EA, Porter GA Jr, Beutner G, Mnatsakanyan N, Alavian KN (2015) Cell death disguised: the mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase. Pharmacol Res 99:382\u2013392. https:\/\/doi.org\/10.1016\/j.phrs.2015.04.013","journal-title":"Pharmacol Res"},{"issue":"2","key":"20_CR182","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10545-011-9382-9","volume":"35","author":"AI Jonckheere","year":"2012","unstructured":"Jonckheere AI, Smeitink JA, Rodenburg RJ (2012) Mitochondrial ATP synthase: architecture, function and pathology. J Inherit Metab Dis 35(2):211\u2013225. https:\/\/doi.org\/10.1007\/s10545-011-9382-9","journal-title":"J Inherit Metab Dis"},{"issue":"16","key":"20_CR183","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1046\/j.1432-1033.2002.03087.x","volume":"269","author":"RA Jones","year":"2002","unstructured":"Jones RA, Smail A, Wilson MR (2002) Detecting mitochondrial permeability transition by confocal imaging of intact cells pinocytically loaded with calcein. Eur J Biochem 269(16):3990\u20133997","journal-title":"Eur J Biochem"},{"issue":"11","key":"20_CR184","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1172\/JCI19906","volume":"113","author":"M Juhaszova","year":"2004","unstructured":"Juhaszova M, Zorov DB, Kim SH, Pepe S, Fu Q, Fishbein KW, Ziman BD, Wang S, Ytrehus K, Antos CL, Olson EN, Sollott SJ (2004) Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 113(11):1535\u20131549. https:\/\/doi.org\/10.1172\/JCI19906","journal-title":"J Clin Invest"},{"issue":"11","key":"20_CR185","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1161\/CIRCRESAHA.109.197996","volume":"104","author":"M Juhaszova","year":"2009","unstructured":"Juhaszova M, Zorov DB, Yaniv Y, Nuss HB, Wang S, Sollott SJ (2009) Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res 104(11):1240\u20131252. https:\/\/doi.org\/10.1161\/CIRCRESAHA.109.197996","journal-title":"Circ Res"},{"key":"20_CR186","doi-asserted-by":"publisher","first-page":"3869610","DOI":"10.1155\/2016\/3869610","volume":"2016","author":"N Kaludercic","year":"2016","unstructured":"Kaludercic N, Giorgio V (2016) The dual function of reactive oxygen\/nitrogen species in bioenergetics and cell death: the role of ATP synthase. Oxidative Med Cell Longev 2016:3869610. https:\/\/doi.org\/10.1155\/2016\/3869610","journal-title":"Oxidative Med Cell Longev"},{"issue":"2","key":"20_CR187","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.cmet.2013.07.002","volume":"18","author":"G Karamanlidis","year":"2013","unstructured":"Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz SC Jr, Suthammarak W, Gong G, Sedensky MM, Morgan PG, Wang W, Tian R (2013) Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure. Cell Metab 18(2):239\u2013250. https:\/\/doi.org\/10.1016\/j.cmet.2013.07.002","journal-title":"Cell Metab"},{"issue":"2","key":"20_CR188","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1177\/1074248410362074","volume":"15","author":"LO Karlsson","year":"2010","unstructured":"Karlsson LO, Zhou AX, Larsson E, Astrom-Olsson K, Mansson C, Akyurek LM, Grip L (2010) Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model. J Cardiovasc Pharmacol Ther 15(2):182\u2013189. https:\/\/doi.org\/10.1177\/1074248410362074","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"3 Pt 2","key":"20_CR189","first-page":"H608","volume":"255","author":"M Karmazyn","year":"1988","unstructured":"Karmazyn M (1988) Amiloride enhances postischemic ventricular recovery: possible role of Na+-H+ exchange. Am J Phys 255(3 Pt 2):H608\u2013H615","journal-title":"Am J Phys"},{"issue":"1","key":"20_CR190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/A:1008990530176","volume":"8","author":"M Karmazyn","year":"1999","unstructured":"Karmazyn M (1999) Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition. J Thromb Thrombolysis 8(1):33\u201338","journal-title":"J Thromb Thrombolysis"},{"issue":"7","key":"20_CR191","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1074\/jbc.M009093200","volume":"276","author":"GF Kelso","year":"2001","unstructured":"Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC, Smith RA, Murphy MP (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 276(7):4588\u20134596. https:\/\/doi.org\/10.1074\/jbc.M009093200","journal-title":"J Biol Chem"},{"issue":"5","key":"20_CR192","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4161\/chan.2.5.6898","volume":"2","author":"G Kemp","year":"2008","unstructured":"Kemp G, Young H, Fliegel L (2008) Structure and function of the human Na+\/H+ exchanger isoform 1. Channels (Austin) 2(5):329\u2013336","journal-title":"Channels (Austin)"},{"issue":"2 Pt 2","key":"20_CR193","first-page":"H496","volume":"276","author":"PM Kerr","year":"1999","unstructured":"Kerr PM, Suleiman MS, Halestrap AP (1999) Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate. Am J Phys 276(2 Pt 2):H496\u2013H502","journal-title":"Am J Phys"},{"issue":"Pt 3","key":"20_CR194","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1113\/jphysiol.2007.130369","volume":"581","author":"I Khaliulin","year":"2007","unstructured":"Khaliulin I, Clarke SJ, Lin H, Parker J, Suleiman MS, Halestrap AP (2007) Temperature preconditioning of isolated rat hearts\u2014a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore. J Physiol 581(Pt 3):1147\u20131161. https:\/\/doi.org\/10.1113\/jphysiol.2007.130369","journal-title":"J Physiol"},{"issue":"2","key":"20_CR195","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/cvr\/cvq190","volume":"88","author":"I Khaliulin","year":"2010","unstructured":"Khaliulin I, Parker JE, Halestrap AP (2010) Consecutive pharmacological activation of PKA and PKC mimics the potent cardioprotection of temperature preconditioning. Cardiovasc Res 88(2):324\u2013333. https:\/\/doi.org\/10.1093\/cvr\/cvq190","journal-title":"Cardiovasc Res"},{"issue":"6","key":"20_CR196","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1258\/ebm.2011.010357","volume":"236","author":"I Khaliulin","year":"2011","unstructured":"Khaliulin I, Halestrap AP, Suleiman MS (2011) Temperature preconditioning is optimal at 26 degrees C and confers additional protection to hypothermic cardioplegic ischemic arrest. Exp Biol Med (Maywood) 236(6):736\u2013745. https:\/\/doi.org\/10.1258\/ebm.2011.010357","journal-title":"Exp Biol Med (Maywood)"},{"issue":"6","key":"20_CR197","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/bph.13709","volume":"174","author":"I Khaliulin","year":"2017","unstructured":"Khaliulin I, Bond M, James AF, Dyar Z, Amini R, Johnson JL, Suleiman MS (2017) Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac. Br J Pharmacol 174(6):438\u2013453. https:\/\/doi.org\/10.1111\/bph.13709","journal-title":"Br J Pharmacol"},{"issue":"9","key":"20_CR198","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1046\/j.1460-9568.1999.00743.x","volume":"11","author":"L Khaspekov","year":"1999","unstructured":"Khaspekov L, Friberg H, Halestrap A, Viktorov I, Wieloch T (1999) Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose\/oxygen deprivation-induced damage to rat cultured hippocampal neurons. Eur J Neurosci 11(9):3194\u20133198","journal-title":"Eur J Neurosci"},{"issue":"5","key":"20_CR199","doi-asserted-by":"publisher","first-page":"H2024","DOI":"10.1152\/ajpheart.00683.2005","volume":"290","author":"JS Kim","year":"2006","unstructured":"Kim JS, Jin Y, Lemasters JJ (2006) Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 290(5):H2024\u2013H2034. https:\/\/doi.org\/10.1152\/ajpheart.00683.2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"20_CR200","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/hep.22187","volume":"47","author":"JS Kim","year":"2008","unstructured":"Kim JS, Nitta T, Mohuczy D, O'Malley KA, Moldawer LL, Dunn WA Jr, Behrns KE (2008) Impaired autophagy: a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology 47(5):1725\u20131736. https:\/\/doi.org\/10.1002\/hep.22187","journal-title":"Hepatology"},{"issue":"4","key":"20_CR201","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF00762521","volume":"21","author":"KW Kinnally","year":"1989","unstructured":"Kinnally KW, Campo ML, Tedeschi H (1989) Mitochondrial channel activity studied by patch-clamping mitoplasts. J Bioenerg Biomembr 21(4):497\u2013506","journal-title":"J Bioenerg Biomembr"},{"issue":"4","key":"20_CR202","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1073\/pnas.90.4.1374","volume":"90","author":"KW Kinnally","year":"1993","unstructured":"Kinnally KW, Zorov DB, Antonenko YN, Snyder SH, McEnery MW, Tedeschi H (1993) Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. Proc Natl Acad Sci U S A 90(4):1374\u20131378","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"20_CR203","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.bbamcr.2010.09.013","volume":"1813","author":"KW Kinnally","year":"2011","unstructured":"Kinnally KW, Peixoto PM, Ryu SY, Dejean LM (2011) Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta 1813(4):616\u2013622. https:\/\/doi.org\/10.1016\/j.bbamcr.2010.09.013","journal-title":"Biochim Biophys Acta"},{"issue":"5 Pt 2","key":"20_CR204","first-page":"H2071","volume":"272","author":"M Kitakaze","year":"1997","unstructured":"Kitakaze M, Takashima S, Funaya H, Minamino T, Node K, Shinozaki Y, Mori H, Hori M (1997) Temporary acidosis during reperfusion limits myocardial infarct size in dogs. Am J Phys 272(5 Pt 2):H2071\u2013H2078","journal-title":"Am J Phys"},{"issue":"9597","key":"20_CR205","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/S0140-6736(07)61634-1","volume":"370","author":"M Kitakaze","year":"2007","unstructured":"Kitakaze M, Asakura M, Kim J, Shintani Y, Asanuma H, Hamasaki T, Seguchi O, Myoishi M, Minamino T, Ohara T, Nagai Y, Nanto S, Watanabe K, Fukuzawa S, Hirayama A, Nakamura N, Kimura K, Fujii K, Ishihara M, Saito Y, Tomoike H, Kitamura S, investigators JW (2007) Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 370(9597):1483\u20131493. https:\/\/doi.org\/10.1016\/S0140-6736(07)61634-1","journal-title":"Lancet"},{"issue":"1","key":"20_CR206","doi-asserted-by":"crossref","first-page":"112","DOI":"10.18433\/J3XG7T","volume":"18","author":"MS Klishadi","year":"2015","unstructured":"Klishadi MS, Zarei F, Hejazian SH, Moradi A, Hemati M, Safari F (2015) Losartan protects the heart against ischemia reperfusion injury: sirtuin3 involvement. J Pharm Pharm Sci 18(1):112\u2013123","journal-title":"J Pharm Pharm Sci"},{"issue":"7","key":"20_CR207","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/j.1440-1681.2008.04925.x","volume":"35","author":"H Kobayashi","year":"2008","unstructured":"Kobayashi H, Miura T, Ishida H, Miki T, Tanno M, Yano T, Sato T, Hotta H, Shimamoto K (2008) Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion. Clin Exp Pharmacol Physiol 35(7):812\u2013819. https:\/\/doi.org\/10.1111\/j.1440-1681.2008.04925.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"3","key":"20_CR208","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.bmcl.2016.12.055","volume":"27","author":"K Kochel","year":"2017","unstructured":"Kochel K, Tomczyk MD, Simoes RF, Fraczek T, Sobon A, Oliveira PJ, Walczak KZ, Koceva-Chyla A (2017) Evaluation of biological properties of 3,3\u2032,4,4\u2032-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity. Bioorg Med Chem Lett 27(3):427\u2013431. https:\/\/doi.org\/10.1016\/j.bmcl.2016.12.055","journal-title":"Bioorg Med Chem Lett"},{"key":"20_CR209","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fcvm.2016.00038","volume":"3","author":"C Koentges","year":"2016","unstructured":"Koentges C, Bode C, Bugger H (2016) SIRT3 in cardiac physiology and disease. Front Cardiovasc Med 3:38. https:\/\/doi.org\/10.3389\/fcvm.2016.00038","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"20_CR210","doi-asserted-by":"publisher","first-page":"H1327","DOI":"10.1152\/ajpheart.00997.2010","volume":"300","author":"MJ Kohr","year":"2011","unstructured":"Kohr MJ, Aponte AM, Sun J, Wang G, Murphy E, Gucek M, Steenbergen C (2011) Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol 300(4):H1327\u2013H1335. https:\/\/doi.org\/10.1152\/ajpheart.00997.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6973","key":"20_CR211","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature02229","volume":"427","author":"JE Kokoszka","year":"2004","unstructured":"Kokoszka JE, Waymire KG, Levy SE, Sligh JE, Cai J, Jones DP, MacGregor GR, Wallace DC (2004) The ADP\/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427(6973):461\u2013465. https:\/\/doi.org\/10.1038\/nature02229","journal-title":"Nature"},{"issue":"24","key":"20_CR212","doi-asserted-by":"publisher","first-page":"9882","DOI":"10.1074\/jbc.M116.768317","volume":"292","author":"P Korge","year":"2017","unstructured":"Korge P, Calmettes G, John SA, Weiss JN (2017a) Reactive oxygen species production induced by pore opening in cardiac mitochondria: the role of complex III. J Biol Chem 292(24):9882\u20139895. https:\/\/doi.org\/10.1074\/jbc.M116.768317","journal-title":"J Biol Chem"},{"issue":"24","key":"20_CR213","doi-asserted-by":"publisher","first-page":"9896","DOI":"10.1074\/jbc.M116.768325","volume":"292","author":"P Korge","year":"2017","unstructured":"Korge P, John SA, Calmettes G, Weiss JN (2017b) Reactive oxygen species production induced by pore opening in cardiac mitochondria: the role of complex II. J Biol Chem 292(24):9896\u20139905. https:\/\/doi.org\/10.1074\/jbc.M116.768325","journal-title":"J Biol Chem"},{"issue":"1","key":"20_CR214","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0005-2728(88)90111-9","volume":"935","author":"M Kottke","year":"1988","unstructured":"Kottke M, Adam V, Riesinger I, Bremm G, Bosch W, Brdiczka D, Sandri G, Panfili E (1988) Mitochondrial boundary membrane contact sites in brain: points of hexokinase and creatine kinase location, and control of Ca2+ transport. Biochim Biophys Acta 935(1):87\u2013102","journal-title":"Biochim Biophys Acta"},{"issue":"1\u20132","key":"20_CR215","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(01)02316-X","volume":"495","author":"AJ Kowaltowski","year":"2001","unstructured":"Kowaltowski AJ, Castilho RF, Vercesi AE (2001) Mitochondrial permeability transition and oxidative stress. FEBS Lett 495(1\u20132):12\u201315","journal-title":"FEBS Lett"},{"issue":"5\u20136","key":"20_CR216","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.bbabio.2006.02.007","volume":"1757","author":"A Krauskopf","year":"2006","unstructured":"Krauskopf A, Eriksson O, Craigen WJ, Forte MA, Bernardi P (2006) Properties of the permeability transition in VDAC1(\u2212\/\u2212) mitochondria. Biochim Biophys Acta 1757(5\u20136):590\u2013595. https:\/\/doi.org\/10.1016\/j.bbabio.2006.02.007","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"20_CR217","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cmet.2014.12.001","volume":"21","author":"JQ Kwong","year":"2015","unstructured":"Kwong JQ, Molkentin JD (2015) Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell Metab 21(2):206\u2013214. https:\/\/doi.org\/10.1016\/j.cmet.2014.12.001","journal-title":"Cell Metab"},{"issue":"1","key":"20_CR218","doi-asserted-by":"publisher","first-page":"205","DOI":"10.14670\/HH-20.205","volume":"20","author":"M Bras Le","year":"2005","unstructured":"Le Bras M, Clement MV, Pervaiz S, Brenner C (2005) Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol 20(1):205\u2013219. https:\/\/doi.org\/10.14670\/HH-20.205","journal-title":"Histol Histopathol"},{"key":"20_CR219","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1479-5876-12-38","volume":"12","author":"S Lamer Le","year":"2014","unstructured":"Le Lamer S, Paradis S, Rahmouni H, Chaimbault C, Michaud M, Culcasi M, Afxantidis J, Latreille M, Berna P, Berdeaux A, Pietri S, Morin D, Donazzolo Y, Abitbol JL, Pruss RM, Schaller S (2014) Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized phase I trial. J Transl Med 12:38. https:\/\/doi.org\/10.1186\/1479-5876-12-38","journal-title":"J Transl Med"},{"issue":"10","key":"20_CR220","doi-asserted-by":"publisher","first-page":"e0164066","DOI":"10.1371\/journal.pone.0164066","volume":"11","author":"S Page Le","year":"2016","unstructured":"Le Page S, Niro M, Fauconnier J, Cellier L, Tamareille S, Gharib A, Chevrollier A, Loufrani L, Grenier C, Kamel R, Sarzi E, Lacampagne A, Ovize M, Henrion D, Reynier P, Lenaers G, Mirebeau-Prunier D, Prunier F (2016) Increase in cardiac ischemia-reperfusion injuries in Opa1+\/\u2212 mouse model. PLoS One 11(10):e0164066. https:\/\/doi.org\/10.1371\/journal.pone.0164066","journal-title":"PLoS One"},{"issue":"3","key":"20_CR221","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.micron.2010.09.002","volume":"42","author":"GJ Lee","year":"2011","unstructured":"Lee GJ, Chae SJ, Jeong JH, Lee SR, Ha SJ, Pak YK, Kim W, Park HK (2011) Characterization of mitochondria isolated from normal and ischemic hearts in rats utilizing atomic force microscopy. Micron 42(3):299\u2013304. https:\/\/doi.org\/10.1016\/j.micron.2010.09.002","journal-title":"Micron"},{"issue":"7","key":"20_CR222","doi-asserted-by":"publisher","first-page":"H1410","DOI":"10.1152\/ajpheart.00731.2011","volume":"302","author":"HL Lee","year":"2012","unstructured":"Lee HL, Chen CL, Yeh ST, Zweier JL, Chen YR (2012) Biphasic modulation of the mitochondrial electron transport chain in myocardial ischemia and reperfusion. Am J Phys Heart Circ Phys 302(7):H1410\u2013H1422. https:\/\/doi.org\/10.1152\/ajpheart.00731.2011","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"6\u20137","key":"20_CR223","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.bbabio.2010.01.034","volume":"1797","author":"AC Leite","year":"2010","unstructured":"Leite AC, Oliveira HC, Utino FL, Garcia R, Alberici LC, Fernandes MP, Castilho RF, Vercesi AE (2010) Mitochondria generated nitric oxide protects against permeability transition via formation of membrane protein S-nitrosothiols. Biochim Biophys Acta 1797(6\u20137):1210\u20131216. https:\/\/doi.org\/10.1016\/j.bbabio.2010.01.034","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"20_CR224","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/S0006-3495(99)77020-7","volume":"77","author":"JJ Lemasters","year":"1999","unstructured":"Lemasters JJ, Nieminen AL (1999) Negative contrast imaging of mitochondria by confocal microscopy. Biophys J 77(3):1747\u20131750. https:\/\/doi.org\/10.1016\/S0006-3495(99)77020-7","journal-title":"Biophys J"},{"issue":"2","key":"20_CR225","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bbamcr.2014.11.002","volume":"1853","author":"AP Leonard","year":"2015","unstructured":"Leonard AP, Cameron RB, Speiser JL, Wolf BJ, Peterson YK, Schnellmann RG, Beeson CC, Rohrer B (2015) Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning. Biochim Biophys Acta 1853(2):348\u2013360. https:\/\/doi.org\/10.1016\/j.bbamcr.2014.11.002","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"20_CR226","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1472-8206.1995.tb00532.x","volume":"9","author":"A Leperre","year":"1995","unstructured":"Leperre A, Millart H, Prevost A, Trenque T, Kantelip JP, Keppler BK (1995) Compared effects of ruthenium red and cis [Ru(NH3)4Cl2]Cl on the isolated ischaemic-reperfused rat heart. Fundam Clin Pharmacol 9(6):545\u2013553","journal-title":"Fundam Clin Pharmacol"},{"issue":"7\u20138","key":"20_CR227","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.bbabio.2008.03.009","volume":"1777","author":"AW Leung","year":"2008","unstructured":"Leung AW, Halestrap AP (2008) Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta 1777(7\u20138):946\u2013952. https:\/\/doi.org\/10.1016\/j.bbabio.2008.03.009","journal-title":"Biochim Biophys Acta"},{"issue":"39","key":"20_CR228","doi-asserted-by":"publisher","first-page":"26312","DOI":"10.1074\/jbc.M805235200","volume":"283","author":"AW Leung","year":"2008","unstructured":"Leung AW, Varanyuwatana P, Halestrap AP (2008) The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition. J Biol Chem 283(39):26312\u201326323. https:\/\/doi.org\/10.1074\/jbc.M805235200","journal-title":"J Biol Chem"},{"issue":"2\u20133","key":"20_CR229","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ejphar.2006.12.027","volume":"560","author":"J Li","year":"2007","unstructured":"Li J, Wang J, Zeng Y (2007) Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition. Eur J Pharmacol 560(2\u20133):117\u2013122. https:\/\/doi.org\/10.1016\/j.ejphar.2006.12.027","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"20_CR230","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1042\/CS20100466","volume":"120","author":"J Li","year":"2011","unstructured":"Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK, Redington AN (2011) Remote preconditioning provides potent cardioprotection via PI3K\/Akt activation and is associated with nuclear accumulation of beta-catenin. Clin Sci (Lond) 120(10):451\u2013462. https:\/\/doi.org\/10.1042\/CS20100466","journal-title":"Clin Sci (Lond)"},{"issue":"Pt 3","key":"20_CR231","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1113\/jphysiol.2002.031484","volume":"545","author":"KH Lim","year":"2002","unstructured":"Lim KH, Javadov SA, Das M, Clarke SJ, Suleiman MS, Halestrap AP (2002) The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration. J Physiol 545(Pt 3):961\u2013974","journal-title":"J Physiol"},{"issue":"3","key":"20_CR232","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.cardiores.2007.04.022","volume":"75","author":"SY Lim","year":"2007","unstructured":"Lim SY, Davidson SM, Hausenloy DJ, Yellon DM (2007) Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore. Cardiovasc Res 75(3):530\u2013535. https:\/\/doi.org\/10.1016\/j.cardiores.2007.04.022","journal-title":"Cardiovasc Res"},{"issue":"1","key":"20_CR233","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1161\/01.CIR.84.1.350","volume":"84","author":"GS Liu","year":"1991","unstructured":"Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM (1991) Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 84(1):350\u2013356","journal-title":"Circulation"},{"issue":"1","key":"20_CR234","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/1755-5922.12225","volume":"35","author":"CW Liu","year":"2017","unstructured":"Liu CW, Yang F, Cheng SZ, Liu Y, Wan LH, Cong HL (2017) Rosuvastatin postconditioning protects isolated hearts against ischemia-reperfusion injury: the role of radical oxygen species, PI3K-Akt-GSK-3beta pathway, and mitochondrial permeability transition pore. Cardiovasc Ther 35(1):3\u20139. https:\/\/doi.org\/10.1111\/1755-5922.12225","journal-title":"Cardiovasc Ther"},{"issue":"1","key":"20_CR235","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.celrep.2015.06.017","volume":"12","author":"TS Luongo","year":"2015","unstructured":"Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW (2015) The mitochondrial calcium uniporter matches energetic supply with cardiac workload during stress and modulates permeability transition. Cell Rep 12(1):23\u201334. https:\/\/doi.org\/10.1016\/j.celrep.2015.06.017","journal-title":"Cell Rep"},{"issue":"6","key":"20_CR236","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1083\/jcb.200105057","volume":"155","author":"M Madesh","year":"2001","unstructured":"Madesh M, Hajnoczky G (2001) VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 155(6):1003\u20131015. https:\/\/doi.org\/10.1083\/jcb.200105057","journal-title":"J Cell Biol"},{"issue":"9341","key":"20_CR237","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0140-6736(02)11278-5","volume":"360","author":"Magnesium in Coronaries Trial I","year":"2002","unstructured":"Magnesium in Coronaries Trial I (2002) Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the magnesium in coronaries (MAGIC) trial: a randomised controlled trial. Lancet 360(9341):1189\u20131196","journal-title":"Lancet"},{"issue":"2","key":"20_CR238","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1525-1373.2000.22319.x","volume":"223","author":"RT Mallet","year":"2000","unstructured":"Mallet RT (2000) Pyruvate: metabolic protector of cardiac performance. Proc Soc Exp Biol Med 223(2):136\u2013148","journal-title":"Proc Soc Exp Biol Med"},{"issue":"7","key":"20_CR239","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/153537020523000701","volume":"230","author":"RT Mallet","year":"2005","unstructured":"Mallet RT, Sun J, Knott EM, Sharma AB, Olivencia-Yurvati AH (2005) Metabolic cardioprotection by pyruvate: recent progress. Exp Biol Med (Maywood) 230(7):435\u2013443","journal-title":"Exp Biol Med (Maywood)"},{"issue":"11","key":"20_CR240","doi-asserted-by":"publisher","first-page":"e14151","DOI":"10.1371\/journal.pone.0014151","volume":"5","author":"Y Manevich","year":"2010","unstructured":"Manevich Y, Townsend DM, Hutchens S, Tew KD (2010) Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase. PLoS One 5(11):e14151. https:\/\/doi.org\/10.1371\/journal.pone.0014151","journal-title":"PLoS One"},{"issue":"1","key":"20_CR241","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4070\/kcj.2016.46.1.1","volume":"46","author":"J Marquez","year":"2016","unstructured":"Marquez J, Lee SR, Kim N, Han J (2016) Post-translational modifications of cardiac mitochondrial proteins in cardiovascular disease: not lost in translation. Korean Circ J 46(1):1\u201312. https:\/\/doi.org\/10.4070\/kcj.2016.46.1.1","journal-title":"Korean Circ J"},{"key":"20_CR001","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3389\/fncel.2014.00433","volume":"8","author":"LJ Martin","year":"2014","unstructured":"Martin LJ, Fancelli D, Wong M, Niedzwiecki M, Ballarini M, Plyte S, Chang Q (2014) GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis. Front Cell Neurosci 8:433. https:\/\/doi.org\/10.3389\/fncel.2014.00433","journal-title":"Front Cell Neurosci"},{"issue":"10","key":"20_CR242","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1016\/j.bbabio.2012.02.022","volume":"1817","author":"I Masgras","year":"2012","unstructured":"Masgras I, Rasola A, Bernardi P (2012) Induction of the permeability transition pore in cells depleted of mitochondrial DNA. Biochim Biophys Acta 1817(10):1860\u20131866. https:\/\/doi.org\/10.1016\/j.bbabio.2012.02.022","journal-title":"Biochim Biophys Acta"},{"issue":"34","key":"20_CR243","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.1038\/sj.onc.1209603","volume":"25","author":"SP Mathupala","year":"2006","unstructured":"Mathupala SP, Ko YH, Pedersen PL (2006) Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25(34):4777\u20134786. https:\/\/doi.org\/10.1038\/sj.onc.1209603","journal-title":"Oncogene"},{"issue":"12","key":"20_CR244","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0024-3205(99)00362-8","volume":"65","author":"H Matsui","year":"1999","unstructured":"Matsui H, Morishima I, Numaguchi Y, Toki Y, Okumura K, Hayakawa T (1999) Protective effects of carvedilol against doxorubicin-induced cardiomyopathy in rats. Life Sci 65(12):1265\u20131274","journal-title":"Life Sci"},{"issue":"6","key":"20_CR245","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.bbamem.2011.10.025","volume":"1818","author":"KS McCommis","year":"2012","unstructured":"McCommis KS, Baines CP (2012) The role of VDAC in cell death: friend or foe? Biochim Biophys Acta 1818(6):1444\u20131450. https:\/\/doi.org\/10.1016\/j.bbamem.2011.10.025","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"20_CR246","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1073\/pnas.89.8.3170","volume":"89","author":"MW McEnery","year":"1992","unstructured":"McEnery MW, Snowman AM, Trifiletti RR, Snyder SH (1992) Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A 89(8):3170\u20133174","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 2","key":"20_CR247","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1042\/BJ20011672","volume":"367","author":"GP McStay","year":"2002","unstructured":"McStay GP, Clarke SJ, Halestrap AP (2002) Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem J 367(Pt 2):541\u2013548. https:\/\/doi.org\/10.1042\/BJ20011672","journal-title":"Biochem J"},{"issue":"4","key":"20_CR248","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.athoracsur.2007.10.054","volume":"85","author":"RM Mentzer Jr","year":"2008","unstructured":"Mentzer RM Jr, Bartels C, Bolli R, Boyce S, Buckberg GD, Chaitman B, Haverich A, Knight J, Menasche P, Myers ML, Nicolau J, Simoons M, Thulin L, Weisel RD, Investigators ES (2008) Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg 85(4):1261\u20131270. https:\/\/doi.org\/10.1016\/j.athoracsur.2007.10.054","journal-title":"Ann Thorac Surg"},{"issue":"15","key":"20_CR249","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1056\/NEJMoa1413579","volume":"373","author":"P Meybohm","year":"2015","unstructured":"Meybohm P, Bein B, Brosteanu O, Cremer J, Gruenewald M, Stoppe C, Coburn M, Schaelte G, Boning A, Niemann B, Roesner J, Kletzin F, Strouhal U, Reyher C, Laufenberg-Feldmann R, Ferner M, Brandes IF, Bauer M, Stehr SN, Kortgen A, Wittmann M, Baumgarten G, Meyer-Treschan T, Kienbaum P, Heringlake M, Schon J, Sander M, Treskatsch S, Smul T, Wolwender E, Schilling T, Fuernau G, Hasenclever D, Zacharowski K, Collaborators RIS (2015) A multicenter trial of remote ischemic preconditioning for heart surgery. N Engl J Med 373(15):1397\u20131407. https:\/\/doi.org\/10.1056\/NEJMoa1413579","journal-title":"N Engl J Med"},{"issue":"7","key":"20_CR250","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1253\/circj.CJ-09-0284","volume":"73","author":"T Miura","year":"2009","unstructured":"Miura T, Miki T (2009) GSK-3beta, a therapeutic target for cardiomyocyte protection. Circ J 73(7):1184\u20131192","journal-title":"Circ J"},{"issue":"3","key":"20_CR251","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10557-010-6234-z","volume":"24","author":"T Miura","year":"2010","unstructured":"Miura T, Tanno M (2010) Mitochondria and GSK-3beta in cardioprotection against ischemia\/reperfusion injury. Cardiovasc Drugs Ther 24(3):255\u2013263. https:\/\/doi.org\/10.1007\/s10557-010-6234-z","journal-title":"Cardiovasc Drugs Ther"},{"issue":"3","key":"20_CR252","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/sj.cdd.4402285","volume":"15","author":"S Miyamoto","year":"2008","unstructured":"Miyamoto S, Murphy AN, Brown JH (2008) Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. Cell Death Differ 15(3):521\u2013529. https:\/\/doi.org\/10.1038\/sj.cdd.4402285","journal-title":"Cell Death Differ"},{"issue":"6","key":"20_CR253","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1006\/jmcc.2002.2006","volume":"34","author":"MM Mocanu","year":"2002","unstructured":"Mocanu MM, Bell RM, Yellon DM (2002) PI3 kinase and not p42\/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol 34(6):661\u2013668. https:\/\/doi.org\/10.1006\/jmcc.2002.2006","journal-title":"J Mol Cell Cardiol"},{"key":"20_CR254","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.yjmcc.2014.08.015","volume":"78","author":"G Morciano","year":"2015","unstructured":"Morciano G, Giorgi C, Bonora M, Punzetti S, Pavasini R, Wieckowski MR, Campo G, Pinton P (2015) Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury. J Mol Cell Cardiol 78:142\u2013153. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.08.015","journal-title":"J Mol Cell Cardiol"},{"key":"20_CR255","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcp.2015.12.003","volume":"105","author":"D Morin","year":"2016","unstructured":"Morin D, Musman J, Pons S, Berdeaux A, Ghaleh B (2016) Mitochondrial translocator protein (TSPO): from physiology to cardioprotection. Biochem Pharmacol 105:1\u201313. https:\/\/doi.org\/10.1016\/j.bcp.2015.12.003","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"20_CR256","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/hh2201.100205","volume":"89","author":"M Murata","year":"2001","unstructured":"Murata M, Akao M, O'Rourke B, Marban E (2001) Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection. Circ Res 89(10):891\u2013898","journal-title":"Circ Res"},{"issue":"2","key":"20_CR257","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0169-409X(99)00069-1","volume":"41","author":"MP Murphy","year":"2000","unstructured":"Murphy MP, Smith RA (2000) Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliv Rev 41(2):235\u2013250","journal-title":"Adv Drug Deliv Rev"},{"key":"20_CR258","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","volume":"47","author":"MP Murphy","year":"2007","unstructured":"Murphy MP, Smith RA (2007) Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47:629\u2013656. https:\/\/doi.org\/10.1146\/annurev.pharmtox.47.120505.105110","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"5","key":"20_CR259","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","volume":"74","author":"CE Murry","year":"1986","unstructured":"Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74(5):1124\u20131136","journal-title":"Circulation"},{"issue":"8","key":"20_CR260","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1111\/bph.12363","volume":"171","author":"R Nederlof","year":"2014","unstructured":"Nederlof R, Eerbeek O, Hollmann MW, Southworth R, Zuurbier CJ (2014) Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart. Br J Pharmacol 171(8):2067\u20132079. https:\/\/doi.org\/10.1111\/bph.12363","journal-title":"Br J Pharmacol"},{"issue":"2","key":"20_CR261","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.mehy.2014.05.004","volume":"83","author":"S Nesci","year":"2014","unstructured":"Nesci S, Ventrella V, Trombetti F, Pirini M, Pagliarani A (2014) Thiol oxidation of mitochondrial F0-c subunits: a way to switch off antimicrobial drug targets of the mitochondrial ATP synthase. Med Hypotheses 83(2):160\u2013165. https:\/\/doi.org\/10.1016\/j.mehy.2014.05.004","journal-title":"Med Hypotheses"},{"issue":"1\u20132","key":"20_CR262","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00232-015-9860-3","volume":"249","author":"S Nesci","year":"2016","unstructured":"Nesci S, Trombetti F, Ventrella V, Pagliarani A (2016) The c-ring of the F1FO-ATP synthase: facts and perspectives. J Membr Biol 249(1\u20132):11\u201321. https:\/\/doi.org\/10.1007\/s00232-015-9860-3","journal-title":"J Membr Biol"},{"issue":"Suppl 11","key":"20_CR263","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1097\/00005344-198710111-00015","volume":"10","author":"G Neugebauer","year":"1987","unstructured":"Neugebauer G, Akpan W, von Mollendorff E, Neubert P, Reiff K (1987) Pharmacokinetics and disposition of carvedilol in humans. J Cardiovasc Pharmacol 10(Suppl 11):S85\u2013S88","journal-title":"J Cardiovasc Pharmacol"},{"issue":"46","key":"20_CR264","doi-asserted-by":"publisher","first-page":"40184","DOI":"10.1074\/jbc.M111.243469","volume":"286","author":"TT Nguyen","year":"2011","unstructured":"Nguyen TT, Stevens MV, Kohr M, Steenbergen C, Sack MN, Murphy E (2011) Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore. J Biol Chem 286(46):40184\u201340192. https:\/\/doi.org\/10.1074\/jbc.M111.243469","journal-title":"J Biol Chem"},{"issue":"4","key":"20_CR265","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1074\/jbc.271.4.2185","volume":"271","author":"A Nicolli","year":"1996","unstructured":"Nicolli A, Basso E, Petronilli V, Wenger RM, Bernardi P (1996) Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. J Biol Chem 271(4):2185\u20132192","journal-title":"J Biol Chem"},{"issue":"5","key":"20_CR266","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.yjmcc.2007.08.010","volume":"43","author":"M Nishihara","year":"2007","unstructured":"Nishihara M, Miura T, Miki T, Tanno M, Yano T, Naitoh K, Ohori K, Hotta H, Terashima Y, Shimamoto K (2007) Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection. J Mol Cell Cardiol 43(5):564\u2013570. https:\/\/doi.org\/10.1016\/j.yjmcc.2007.08.010","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"20_CR267","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1253\/circj.CJ-07-0760","volume":"72","author":"F Nomura","year":"2008","unstructured":"Nomura F, Kurobe N, Mori Y, Hikita A, Kawai M, Suwa M, Okutani Y (2008) Multicenter prospective investigation on efficacy and safety of carperitide as a first-line drug for acute heart failure syndrome with preserved blood pressure: COMPASS: carperitide effects observed through monitoring dyspnea in acute decompensated heart failure study. Circ J 72(11):1777\u20131786","journal-title":"Circ J"},{"issue":"2","key":"20_CR268","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00000542-200308000-00024","volume":"99","author":"E Novalija","year":"2003","unstructured":"Novalija E, Kevin LG, Camara AK, Bosnjak ZJ, Kampine JP, Stowe DF (2003) Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade. Anesthesiology 99(2):421\u2013428","journal-title":"Anesthesiology"},{"issue":"1","key":"20_CR269","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1124\/jpet.107.124255","volume":"323","author":"FN Obame","year":"2007","unstructured":"Obame FN, Zini R, Souktani R, Berdeaux A, Morin D (2007) Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization. J Pharmacol Exp Ther 323(1):336\u2013345. https:\/\/doi.org\/10.1124\/jpet.107.124255","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"20_CR270","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1124\/jpet.108.138008","volume":"326","author":"FN Obame","year":"2008","unstructured":"Obame FN, Plin-Mercier C, Assaly R, Zini R, Dubois-Rande JL, Berdeaux A, Morin D (2008) Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore. J Pharmacol Exp Ther 326(1):252\u2013258. https:\/\/doi.org\/10.1124\/jpet.108.138008","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"20_CR271","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/iub.1323","volume":"66","author":"A Odunewu-Aderibigbe","year":"2014","unstructured":"Odunewu-Aderibigbe A, Fliegel L (2014) The Na(+) \/H(+) exchanger and pH regulation in the heart. IUBMB Life 66(10):679\u2013685. https:\/\/doi.org\/10.1002\/iub.1323","journal-title":"IUBMB Life"},{"issue":"2","key":"20_CR272","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0014-5793(97)01045-4","volume":"414","author":"E O'Gorman","year":"1997","unstructured":"O'Gorman E, Beutner G, Dolder M, Koretsky AP, Brdiczka D, Wallimann T (1997) The role of creatine kinase in inhibition of mitochondrial permeability transition. FEBS Lett 414(2):253\u2013257","journal-title":"FEBS Lett"},{"issue":"1","key":"20_CR273","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1006\/bbrc.2000.3374","volume":"276","author":"PJ Oliveira","year":"2000","unstructured":"Oliveira PJ, Marques MP, Batista de Carvalho LA, Moreno AJ (2000a) Effects of carvedilol on isolated heart mitochondria: evidence for a protonophoretic mechanism. Biochem Biophys Res Commun 276(1):82\u201387. https:\/\/doi.org\/10.1006\/bbrc.2000.3374","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"20_CR274","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1006\/abbi.1999.1624","volume":"374","author":"PJ Oliveira","year":"2000","unstructured":"Oliveira PJ, Santos DJ, Moreno AJ (2000b) Carvedilol inhibits the exogenous NADH dehydrogenase in rat heart mitochondria. Arch Biochem Biophys 374(2):279\u2013285. https:\/\/doi.org\/10.1006\/abbi.1999.1624","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"20_CR275","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-2999(01)00745-2","volume":"412","author":"PJ Oliveira","year":"2001","unstructured":"Oliveira PJ, Coxito PM, Rolo AP, Santos DL, Palmeira CM, Moreno AJ (2001a) Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore. Eur J Pharmacol 412(3):231\u2013237","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"20_CR276","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0024-3205(01)01109-2","volume":"69","author":"PJ Oliveira","year":"2001","unstructured":"Oliveira PJ, Rolo AP, Sardao VA, Coxito PM, Palmeira CM, Moreno AJ (2001b) Carvedilol in heart mitochondria: protonophore or opener of the mitochondrial K(ATP) channels? Life Sci 69(2):123\u2013132","journal-title":"Life Sci"},{"issue":"2","key":"20_CR277","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.taap.2004.04.005","volume":"200","author":"PJ Oliveira","year":"2004","unstructured":"Oliveira PJ, Bjork JA, Santos MS, Leino RL, Froberg MK, Moreno AJ, Wallace KB (2004a) Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity. Toxicol Appl Pharmacol 200(2):159\u2013168. https:\/\/doi.org\/10.1016\/j.taap.2004.04.005","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"20_CR278","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/CT:4:1:11","volume":"4","author":"PJ Oliveira","year":"2004","unstructured":"Oliveira PJ, Esteves T, Rolo AP, Palmeira CM, Moreno AJ (2004b) Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism. Cardiovasc Toxicol 4(1):11\u201320","journal-title":"Cardiovasc Toxicol"},{"issue":"18","key":"20_CR279","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1161\/CIRCULATIONAHA.109.906610","volume":"121","author":"SB Ong","year":"2010","unstructured":"Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, Hausenloy DJ (2010) Inhibiting mitochondrial fission protects the heart against ischemia\/reperfusion injury. Circulation 121(18):2012\u20132022. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.906610","journal-title":"Circulation"},{"issue":"8","key":"20_CR280","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1111\/bph.13013","volume":"172","author":"SB Ong","year":"2015","unstructured":"Ong SB, Dongworth RK, Cabrera-Fuentes HA, Hausenloy DJ (2015a) Role of the MPTP in conditioning the heart\u00a0\u2013 translatability and mechanism. Br J Pharmacol 172(8):2074\u20132084. https:\/\/doi.org\/10.1111\/bph.13013","journal-title":"Br J Pharmacol"},{"issue":"3","key":"20_CR281","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1160\/TH14-07-0592","volume":"113","author":"SB Ong","year":"2015","unstructured":"Ong SB, Hall AR, Dongworth RK, Kalkhoran S, Pyakurel A, Scorrano L, Hausenloy DJ (2015b) Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology. Thromb Haemost 113(3):513\u2013521. https:\/\/doi.org\/10.1160\/TH14-07-0592","journal-title":"Thromb Haemost"},{"key":"20_CR282","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.yjmcc.2014.11.005","volume":"78","author":"SB Ong","year":"2015","unstructured":"Ong SB, Samangouei P, Kalkhoran SB, Hausenloy DJ (2015c) The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury. J Mol Cell Cardiol 78:23\u201334. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.11.005","journal-title":"J Mol Cell Cardiol"},{"issue":"1\u20133","key":"20_CR283","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejphar.2011.11.040","volume":"675","author":"A Onishi","year":"2012","unstructured":"Onishi A, Miyamae M, Kaneda K, Kotani J, Figueredo VM (2012) Direct evidence for inhibition of mitochondrial permeability transition pore opening by sevoflurane preconditioning in cardiomyocytes: comparison with cyclosporine A. Eur J Pharmacol 675(1\u20133):40\u201346. https:\/\/doi.org\/10.1016\/j.ejphar.2011.11.040","journal-title":"Eur J Pharmacol"},{"key":"20_CR284","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ejphar.2014.09.042","volume":"744","author":"P Ortiz-Vilchis","year":"2014","unstructured":"Ortiz-Vilchis P, Yamazaki KG, Rubio-Gayosso I, Ramirez-Sanchez I, Calzada C, Romero-Perez D, Ortiz A, Meaney E, Taub P, Villarreal F, Ceballos G (2014) Co-administration of the flavanol (\u2212)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling. Eur J Pharmacol 744:76\u201382. https:\/\/doi.org\/10.1016\/j.ejphar.2014.09.042","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"20_CR285","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.bbamcr.2013.02.002","volume":"1833","author":"H Otera","year":"2013","unstructured":"Otera H, Ishihara N, Mihara K (2013) New insights into the function and regulation of mitochondrial fission. Biochim Biophys Acta 1833(5):1256\u20131268. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.02.002","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"20_CR286","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jacc.2015.10.081","volume":"67","author":"F Ottani","year":"2016","unstructured":"Ottani F, Latini R, Staszewsky L, La Vecchia L, Locuratolo N, Sicuro M, Masson S, Barlera S, Milani V, Lombardi M, Costalunga A, Mollichelli N, Santarelli A, De Cesare N, Sganzerla P, Boi A, Maggioni AP, Limbruno U, Investigators C (2016) Cyclosporine A in reperfused myocardial infarction: the multicenter, controlled, open-label CYCLE trial. J Am Coll Cardiol 67(4):365\u2013374. https:\/\/doi.org\/10.1016\/j.jacc.2015.10.081","journal-title":"J Am Coll Cardiol"},{"issue":"Pt 3","key":"20_CR287","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj3480607","volume":"348","author":"MR Owen","year":"2000","unstructured":"Owen MR, Doran E, Halestrap AP (2000) Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348(Pt 3):607\u2013614","journal-title":"Biochem J"},{"issue":"12","key":"20_CR288","doi-asserted-by":"publisher","first-page":"4766","DOI":"10.1096\/fj.15-275404","volume":"29","author":"AO Oyewole","year":"2015","unstructured":"Oyewole AO, Birch-Machin MA (2015) Mitochondria-targeted antioxidants. FASEB J 29(12):4766\u20134771. https:\/\/doi.org\/10.1096\/fj.15-275404","journal-title":"FASEB J"},{"issue":"1","key":"20_CR289","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1038\/s41598-017-04618-4","volume":"7","author":"M Panel","year":"2017","unstructured":"Panel M, Ghaleh B, Morin D (2017) Ca2+ ionophores are not suitable for inducing mPTP opening in murine isolated adult cardiac myocytes. Sci Rep 7(1):4283. https:\/\/doi.org\/10.1038\/s41598-017-04618-4","journal-title":"Sci Rep"},{"issue":"1","key":"20_CR290","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1124\/jpet.106.101477","volume":"318","author":"SS Park","year":"2006","unstructured":"Park SS, Zhao H, Jang Y, Mueller RA, Xu Z (2006a) N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta. J Pharmacol Exp Ther 318(1):124\u2013131. https:\/\/doi.org\/10.1124\/jpet.106.101477","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"20_CR291","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.yjmcc.2006.01.024","volume":"40","author":"SS Park","year":"2006","unstructured":"Park SS, Zhao H, Mueller RA, Xu Z (2006b) Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta. J Mol Cell Cardiol 40(5):708\u2013716. https:\/\/doi.org\/10.1016\/j.yjmcc.2006.01.024","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"20_CR292","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1042\/BJ20101957","volume":"436","author":"P Pasdois","year":"2011","unstructured":"Pasdois P, Parker JE, Griffiths EJ, Halestrap AP (2011) The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Biochem J 436(2):493\u2013505. https:\/\/doi.org\/10.1042\/BJ20101957","journal-title":"Biochem J"},{"issue":"1","key":"20_CR293","doi-asserted-by":"publisher","first-page":"e005645","DOI":"10.1161\/JAHA.112.005645","volume":"2","author":"P Pasdois","year":"2012","unstructured":"Pasdois P, Parker JE, Halestrap AP (2012) Extent of mitochondrial hexokinase II dissociation during ischemia correlates with mitochondrial cytochrome c release, reactive oxygen species production, and infarct size on reperfusion. J Am Heart Assoc 2(1):e005645. https:\/\/doi.org\/10.1161\/JAHA.112.005645","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"20_CR294","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10863-008-9148-8","volume":"40","author":"JG Pastorino","year":"2008","unstructured":"Pastorino JG, Hoek JB (2008) Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr 40(3):171\u2013182. https:\/\/doi.org\/10.1007\/s10863-008-9148-8","journal-title":"J Bioenerg Biomembr"},{"issue":"9","key":"20_CR295","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.1074\/jbc.M109950200","volume":"277","author":"JG Pastorino","year":"2002","unstructured":"Pastorino JG, Shulga N, Hoek JB (2002) Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 277(9):7610\u20137618. https:\/\/doi.org\/10.1074\/jbc.M109950200","journal-title":"J Biol Chem"},{"issue":"22","key":"20_CR296","doi-asserted-by":"publisher","first-page":"10545","DOI":"10.1158\/0008-5472.CAN-05-1925","volume":"65","author":"JG Pastorino","year":"2005","unstructured":"Pastorino JG, Hoek JB, Shulga N (2005) Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res 65(22):10545\u201310554. https:\/\/doi.org\/10.1158\/0008-5472.CAN-05-1925","journal-title":"Cancer Res"},{"issue":"20","key":"20_CR297","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2174\/138161211796904812","volume":"17","author":"GC Pereira","year":"2011","unstructured":"Pereira GC, Silva AM, Diogo CV, Carvalho FS, Monteiro P, Oliveira PJ (2011) Drug-induced cardiac mitochondrial toxicity and protection: from doxorubicin to carvedilol. Curr Pharm Des 17(20):2113\u20132129","journal-title":"Curr Pharm Des"},{"key":"20_CR298","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.phrs.2014.08.004","volume":"89","author":"AJ Perricone","year":"2014","unstructured":"Perricone AJ, Vander Heide RS (2014) Novel therapeutic strategies for ischemic heart disease. Pharmacol Res 89:36\u201345. https:\/\/doi.org\/10.1016\/j.phrs.2014.08.004","journal-title":"Pharmacol Res"},{"issue":"1","key":"20_CR299","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-5793(89)81513-3","volume":"259","author":"V Petronilli","year":"1989","unstructured":"Petronilli V, Szabo I, Zoratti M (1989) The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria. FEBS Lett 259(1):137\u2013143","journal-title":"FEBS Lett"},{"issue":"3\u20134","key":"20_CR300","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/biof.5520080314","volume":"8","author":"V Petronilli","year":"1998","unstructured":"Petronilli V, Miotto G, Canton M, Colonna R, Bernardi P, Di Lisa F (1998) Imaging the mitochondrial permeability transition pore in intact cells. Biofactors 8(3\u20134):263\u2013272","journal-title":"Biofactors"},{"issue":"2","key":"20_CR301","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0006-3495(99)77239-5","volume":"76","author":"V Petronilli","year":"1999","unstructured":"Petronilli V, Miotto G, Canton M, Brini M, Colonna R, Bernardi P, Di Lisa F (1999) Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 76(2):725\u2013734. https:\/\/doi.org\/10.1016\/S0006-3495(99)77239-5","journal-title":"Biophys J"},{"issue":"6","key":"20_CR302","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.bbagen.2011.03.008","volume":"1820","author":"CA Piantadosi","year":"2012","unstructured":"Piantadosi CA (2012) Regulation of mitochondrial processes by protein S-nitrosylation. Biochim Biophys Acta 1820(6):712\u2013721. https:\/\/doi.org\/10.1016\/j.bbagen.2011.03.008","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"20_CR303","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1006\/niox.2001.0368","volume":"6","author":"CA Piantadosi","year":"2002","unstructured":"Piantadosi CA, Tatro LG, Whorton AR (2002) Nitric oxide and differential effects of ATP on mitochondrial permeability transition. Nitric Oxide 6(1):45\u201360. https:\/\/doi.org\/10.1006\/niox.2001.0368","journal-title":"Nitric Oxide"},{"issue":"5","key":"20_CR304","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1056\/NEJMoa071142","volume":"359","author":"C Piot","year":"2008","unstructured":"Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, Andre-Fouet X, Revel D, Kirkorian G, Monassier JP, Derumeaux G, Ovize M (2008) Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 359(5):473\u2013481. https:\/\/doi.org\/10.1056\/NEJMoa071142","journal-title":"N Engl J Med"},{"issue":"3","key":"20_CR305","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1093\/cvr\/cvs117","volume":"94","author":"J Piquereau","year":"2012","unstructured":"Piquereau J, Caffin F, Novotova M, Prola A, Garnier A, Mateo P, Fortin D, Huynh le H, Nicolas V, Alavi MV, Brenner C, Ventura-Clapier R, Veksler V, Joubert F (2012) Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res 94(3):408\u2013417. https:\/\/doi.org\/10.1093\/cvr\/cvs117","journal-title":"Cardiovasc Res"},{"issue":"3","key":"20_CR306","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2165\/00007256-200030030-00002","volume":"30","author":"JR Poortmans","year":"2000","unstructured":"Poortmans JR, Francaux M (2000) Adverse effects of creatine supplementation: fact or fiction? Sports Med 30(3):155\u2013170","journal-title":"Sports Med"},{"issue":"2","key":"20_CR307","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1440-1681.2007.04800.x","volume":"35","author":"MG Prendes","year":"2008","unstructured":"Prendes MG, Torresin E, Gonzalez M, Fernandez MA, Perazzo JC, Savino EA, Varela A (2008) Protection of ischaemic-reperfused rat heart by dimethylamiloride is associated with inhibition of mitochondrial permeability transition. Clin Exp Pharmacol Physiol 35(2):201\u2013206. https:\/\/doi.org\/10.1111\/j.1440-1681.2007.04800.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"26","key":"20_CR308","doi-asserted-by":"publisher","first-page":"10764","DOI":"10.1073\/pnas.0903250106","volume":"106","author":"TA Prime","year":"2009","unstructured":"Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP (2009) A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A 106(26):10764\u201310769. https:\/\/doi.org\/10.1073\/pnas.0903250106","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"20_CR309","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.molcel.2015.08.001","volume":"59","author":"J Prudent","year":"2015","unstructured":"Prudent J, Zunino R, Sugiura A, Mattie S, Shore GC, McBride HM (2015) MAPL SUMOylation of Drp1 stabilizes an ER\/mitochondrial platform required for cell death. Mol Cell 59(6):941\u2013955. https:\/\/doi.org\/10.1016\/j.molcel.2015.08.001","journal-title":"Mol Cell"},{"issue":"3","key":"20_CR310","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.CIR.87.3.893","volume":"87","author":"K Przyklenk","year":"1993","unstructured":"Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P (1993) Regional ischemic \u2018preconditioning\u2019 protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 87(3):893\u2013899","journal-title":"Circulation"},{"key":"20_CR311","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.lfs.2015.12.043","volume":"145","author":"M Rameshrad","year":"2016","unstructured":"Rameshrad M, Babaei H, Azarmi Y, Fouladia DF (2016) Rat aorta as a pharmacological tool for in vitro and in vivo studies. Life Sci 145:190\u2013204. https:\/\/doi.org\/10.1016\/j.lfs.2015.12.043","journal-title":"Life Sci"},{"issue":"3","key":"20_CR312","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ceca.2011.04.007","volume":"50","author":"A Rasola","year":"2011","unstructured":"Rasola A, Bernardi P (2011) Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. Cell Calcium 50(3):222\u2013233. https:\/\/doi.org\/10.1016\/j.ceca.2011.04.007","journal-title":"Cell Calcium"},{"issue":"2","key":"20_CR313","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1073\/pnas.0912742107","volume":"107","author":"A Rasola","year":"2010","unstructured":"Rasola A, Sciacovelli M, Chiara F, Pantic B, Brusilow WS, Bernardi P (2010) Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. Proc Natl Acad Sci U S A 107(2):726\u2013731. https:\/\/doi.org\/10.1073\/pnas.0912742107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"20_CR314","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pcad.2004.04.004","volume":"47","author":"MJ Reiter","year":"2004","unstructured":"Reiter MJ (2004) Cardiovascular drug class specificity: beta-blockers. Prog Cardiovasc Dis 47(1):11\u201333","journal-title":"Prog Cardiovasc Dis"},{"issue":"5","key":"20_CR315","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.bbabio.2011.02.012","volume":"1807","author":"F Ricchelli","year":"2011","unstructured":"Ricchelli F, Sileikyte J, Bernardi P (2011) Shedding light on the mitochondrial permeability transition. Biochim Biophys Acta 1807(5):482\u2013490. https:\/\/doi.org\/10.1016\/j.bbabio.2011.02.012","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"20_CR002","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1042\/BCJ20160070","volume":"473","author":"AP Richardson","year":"2016","unstructured":"Richardson AP, Halestrap AP (2016) Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity. Biochem J 473(9):1129\u20131140. https:\/\/doi.org\/10.1042\/BCJ20160070","journal-title":"Biochem J"},{"issue":"11","key":"20_CR316","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.bbabio.2009.03.015","volume":"1787","author":"R Rizzuto","year":"2009","unstructured":"Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta 1787(11):1342\u20131351. https:\/\/doi.org\/10.1016\/j.bbabio.2009.03.015","journal-title":"Biochim Biophys Acta"},{"issue":"33","key":"20_CR317","doi-asserted-by":"publisher","first-page":"23798","DOI":"10.1074\/jbc.M113.482026","volume":"288","author":"DJ Roberts","year":"2013","unstructured":"Roberts DJ, Tan-Sah VP, Smith JM, Miyamoto S (2013) Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem 288(33):23798\u201323806. https:\/\/doi.org\/10.1074\/jbc.M113.482026","journal-title":"J Biol Chem"},{"issue":"34","key":"20_CR318","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.1038\/sj.onc.1209595","volume":"25","author":"RB Robey","year":"2006","unstructured":"Robey RB, Hay N (2006) Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25(34):4683\u20134696. https:\/\/doi.org\/10.1038\/sj.onc.1209595","journal-title":"Oncogene"},{"issue":"6","key":"20_CR319","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0008-6363(95)00154-9","volume":"30","author":"S Rohmann","year":"1995","unstructured":"Rohmann S, Weygandt H, Minck KO (1995) Preischaemic as well as postischaemic application of a Na+\/H+ exchange inhibitor reduces infarct size in pigs. Cardiovasc Res 30(6):945\u2013951","journal-title":"Cardiovasc Res"},{"issue":"2","key":"20_CR320","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1432-1033.1980.tb04870.x","volume":"110","author":"I Roos","year":"1980","unstructured":"Roos I, Crompton M, Carafoli E (1980) The role of inorganic phosphate in the release of Ca2+ from rat-liver mitochondria. Eur J Biochem 110(2):319\u2013325","journal-title":"Eur J Biochem"},{"issue":"10","key":"20_CR321","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1002\/cmdc.201500284","volume":"10","author":"S Roy","year":"2015","unstructured":"Roy S, Sileikyte J, Schiavone M, Neuenswander B, Argenton F, Aube J, Hedrick MP, Chung TD, Forte MA, Bernardi P, Schoenen FJ (2015) Discovery, synthesis, and optimization of diarylisoxazole-3-carboxamides as potent inhibitors of the mitochondrial permeability transition pore. ChemMedChem 10(10):1655\u20131671. https:\/\/doi.org\/10.1002\/cmdc.201500284","journal-title":"ChemMedChem"},{"issue":"3","key":"20_CR322","doi-asserted-by":"publisher","first-page":"H999","DOI":"10.1152\/ajpheart.00035.2003","volume":"285","author":"M Ruiz-Meana","year":"2003","unstructured":"Ruiz-Meana M, Garcia-Dorado D, Pina P, Inserte J, Agullo L, Soler-Soler J (2003) Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. Am J Physiol Heart Circ Physiol 285(3):H999\u20131006. https:\/\/doi.org\/10.1152\/ajpheart.00035.2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"20_CR323","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s00395-011-0225-5","volume":"106","author":"M Ruiz-Meana","year":"2011","unstructured":"Ruiz-Meana M, Inserte J, Fernandez-Sanz C, Hernando V, Miro-Casas E, Barba I, Garcia-Dorado D (2011) The role of mitochondrial permeability transition in reperfusion-induced cardiomyocyte death depends on the duration of ischemia. Basic Res Cardiol 106(6):1259\u20131268. https:\/\/doi.org\/10.1007\/s00395-011-0225-5","journal-title":"Basic Res Cardiol"},{"issue":"25","key":"20_CR324","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/01.CIR.101.25.2902","volume":"101","author":"HJ Rupprecht","year":"2000","unstructured":"Rupprecht HJ, vom Dahl J, Terres W, Seyfarth KM, Richardt G, Schultheibeta HP, Buerke M, Sheehan FH, Drexler H (2000) Cardioprotective effects of the Na(+)\/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation 101(25):2902\u20132908","journal-title":"Circulation"},{"issue":"3","key":"20_CR325","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/taap.2002.9532","volume":"185","author":"DL Santos","year":"2002","unstructured":"Santos DL, Moreno AJ, Leino RL, Froberg MK, Wallace KB (2002) Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy. Toxicol Appl Pharmacol 185(3):218\u2013227","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"20_CR326","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(89)90901-X","volume":"56","author":"C Sardet","year":"1989","unstructured":"Sardet C, Franchi A, Pouyssegur J (1989) Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+\/H+ antiporter. Cell 56(2):271\u2013280","journal-title":"Cell"},{"issue":"3","key":"20_CR327","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0008-6363(02)00325-5","volume":"55","author":"AT Saurin","year":"2002","unstructured":"Saurin AT, Pennington DJ, Raat NJ, Latchman DS, Owen MJ, Marber MS (2002) Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res 55(3):672\u2013680","journal-title":"Cardiovasc Res"},{"issue":"3","key":"20_CR328","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1124\/jpet.110.167486","volume":"333","author":"S Schaller","year":"2010","unstructured":"Schaller S, Paradis S, Ngoh GA, Assaly R, Buisson B, Drouot C, Ostuni MA, Lacapere JJ, Bassissi F, Bordet T, Berdeaux A, Jones SP, Morin D, Pruss RM (2010) TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition. J Pharmacol Exp Ther 333(3):696\u2013706. https:\/\/doi.org\/10.1124\/jpet.110.167486","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"20_CR329","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbadis.2005.09.004","volume":"1762","author":"U Schlattner","year":"2006","unstructured":"Schlattner U, Tokarska-Schlattner M, Wallimann T (2006) Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta 1762(2):164\u2013180. https:\/\/doi.org\/10.1016\/j.bbadis.2005.09.004","journal-title":"Biochim Biophys Acta"},{"issue":"16","key":"20_CR330","doi-asserted-by":"crossref","first-page":"10558","DOI":"10.1074\/jbc.272.16.10558","volume":"272","author":"A Schroers","year":"1997","unstructured":"Schroers A, Kramer R, Wohlrab H (1997) The reversible antiport-uniport conversion of the phosphate carrier from yeast mitochondria depends on the presence of a single cysteine. J Biol Chem 272(16):10558\u201310564","journal-title":"J Biol Chem"},{"issue":"1","key":"20_CR331","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.taap.2013.08.027","volume":"273","author":"J Schwartz","year":"2013","unstructured":"Schwartz J, Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ (2013) Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia\/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol 273(1):172\u2013179. https:\/\/doi.org\/10.1016\/j.taap.2013.08.027","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"20_CR332","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/cvr\/cvv097","volume":"106","author":"LK Seidlmayer","year":"2015","unstructured":"Seidlmayer LK, Juettner VV, Kettlewell S, Pavlov EV, Blatter LA, Dedkova EN (2015) Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate. Cardiovasc Res 106(2):237\u2013248. https:\/\/doi.org\/10.1093\/cvr\/cvv097","journal-title":"Cardiovasc Res"},{"issue":"3","key":"20_CR333","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbabio.2007.01.023","volume":"1767","author":"P Sgobbo","year":"2007","unstructured":"Sgobbo P, Pacelli C, Grattagliano I, Villani G, Cocco T (2007) Carvedilol inhibits mitochondrial complex I and induces resistance to H2O2-mediated oxidative insult in H9C2 myocardial cells. Biochim Biophys Acta 1767(3):222\u2013232. https:\/\/doi.org\/10.1016\/j.bbabio.2007.01.023","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"20_CR334","doi-asserted-by":"publisher","first-page":"H237","DOI":"10.1152\/ajpheart.01192.2004","volume":"289","author":"S Shanmuganathan","year":"2005","unstructured":"Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM (2005) Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. Am J Physiol Heart Circ Physiol 289(1):H237\u2013H242. https:\/\/doi.org\/10.1152\/ajpheart.01192.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"20_CR335","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1096\/fj.12-226225","volume":"28","author":"WW Sharp","year":"2014","unstructured":"Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, Morrow E, Ryan JJ, Archer SL (2014) Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J 28(1):316\u2013326. https:\/\/doi.org\/10.1096\/fj.12-226225","journal-title":"FASEB J"},{"key":"20_CR336","doi-asserted-by":"publisher","unstructured":"Shim HS, Park JH, Kim YA, Han JY, Park M, Song YG, Kim JS, Shin IW (2016) Ethyl pyruvate has anti-apoptotic and myocardial protective effects after regional ischaemia\/reperfusion myocardial damage in an in vivo rat model. Singapore Med J. https:\/\/doi.org\/10.11622\/smedj.2016190","DOI":"10.11622\/smedj.2016190"},{"issue":"20","key":"20_CR337","doi-asserted-by":"publisher","first-page":"13769","DOI":"10.1074\/jbc.M114.549634","volume":"289","author":"J Sileikyte","year":"2014","unstructured":"Sileikyte J, Blachly-Dyson E, Sewell R, Carpi A, Menabo R, Di Lisa F, Ricchelli F, Bernardi P, Forte M (2014) Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18\u00a0kDa (TSPO)). J Biol Chem 289(20):13769\u201313781. https:\/\/doi.org\/10.1074\/jbc.M114.549634","journal-title":"J Biol Chem"},{"issue":"37","key":"20_CR338","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.2174\/1381612822666160822150243","volume":"22","author":"FS Silva","year":"2016","unstructured":"Silva FS, Simoes RF, Couto R, Oliveira PJ (2016) Targeting mitochondria in cardiovascular diseases. Curr Pharm Des 22(37):5698\u20135717","journal-title":"Curr Pharm Des"},{"issue":"4","key":"20_CR339","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1172\/JCI35814","volume":"119","author":"MV Singh","year":"2009","unstructured":"Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME (2009) Ca2+\/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest 119(4):986\u2013996. https:\/\/doi.org\/10.1172\/JCI35814","journal-title":"J Clin Invest"},{"issue":"12","key":"20_CR340","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1134\/S0006297907120139","volume":"72","author":"VP Skulachev","year":"2007","unstructured":"Skulachev VP (2007) A biochemical approach to the problem of aging: \u201cmegaproject\u201d on membrane-penetrating ions. The first results and prospects. Biochemistry (Mosc) 72(12):1385\u20131396","journal-title":"Biochemistry (Mosc)"},{"issue":"5","key":"20_CR341","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.bbabio.2008.12.008","volume":"1787","author":"VP Skulachev","year":"2009","unstructured":"Skulachev VP, Anisimov VN, Antonenko YN, Bakeeva LE, Chernyak BV, Erichev VP, Filenko OF, Kalinina NI, Kapelko VI, Kolosova NG, Kopnin BP, Korshunova GA, Lichinitser MR, Obukhova LA, Pasyukova EG, Pisarenko OI, Roginsky VA, Ruuge EK, Senin II, Severina II, Skulachev MV, Spivak IM, Tashlitsky VN, Tkachuk VA, Vyssokikh MY, Yaguzhinsky LS, Zorov DB (2009) An attempt to prevent senescence: a mitochondrial approach. Biochim Biophys Acta 1787(5):437\u2013461. https:\/\/doi.org\/10.1016\/j.bbabio.2008.12.008","journal-title":"Biochim Biophys Acta"},{"issue":"6\u20137","key":"20_CR342","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbabio.2010.03.015","volume":"1797","author":"VP Skulachev","year":"2010","unstructured":"Skulachev VP, Antonenko YN, Cherepanov DA, Chernyak BV, Izyumov DS, Khailova LS, Klishin SS, Korshunova GA, Lyamzaev KG, Pletjushkina OY, Roginsky VA, Rokitskaya TI, Severin FF, Severina II, Simonyan RA, Skulachev MV, Sumbatyan NV, Sukhanova EI, Tashlitsky VN, Trendeleva TA, Vyssokikh MY, Zvyagilskaya RA (2010) Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs). Biochim Biophys Acta 1797(6\u20137):878\u2013889. https:\/\/doi.org\/10.1016\/j.bbabio.2010.03.015","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"20_CR343","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.yjmcc.2012.02.009","volume":"52","author":"RC Sloan","year":"2012","unstructured":"Sloan RC, Moukdar F, Frasier CR, Patel HD, Bostian PA, Lust RM, Brown DA (2012) Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. J Mol Cell Cardiol 52(5):1009\u20131018. https:\/\/doi.org\/10.1016\/j.yjmcc.2012.02.009","journal-title":"J Mol Cell Cardiol"},{"issue":"10","key":"20_CR344","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1161\/CIRCRESAHA.111.244962","volume":"108","author":"KM Smeele","year":"2011","unstructured":"Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ (2011) Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis. Circ Res 108(10):1165\u20131169. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.244962","journal-title":"Circ Res"},{"issue":"6","key":"20_CR345","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.tips.2012.03.010","volume":"33","author":"RA Smith","year":"2012","unstructured":"Smith RA, Hartley RC, Cocheme HM, Murphy MP (2012) Mitochondrial pharmacology. Trends Pharmacol Sci 33(6):341\u2013352. https:\/\/doi.org\/10.1016\/j.tips.2012.03.010","journal-title":"Trends Pharmacol Sci"},{"issue":"11","key":"20_CR346","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","volume":"25","author":"BJ Snow","year":"2010","unstructured":"Snow BJ, Rolfe FL, Lockhart MM, Frampton CM, O'Sullivan JD, Fung V, Smith RA, Murphy MP, Taylor KM, Protect Study G (2010) A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson\u2019s disease. Mov Disord 25(11):1670\u20131674. https:\/\/doi.org\/10.1002\/mds.23148","journal-title":"Mov Disord"},{"issue":"4","key":"20_CR347","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1006\/jmcc.1998.0925","volume":"31","author":"S Soboll","year":"1999","unstructured":"Soboll S, Brdiczka D, Jahnke D, Schmidt A, Schlattner U, Wendt S, Wyss M, Wallimann T (1999) Octamer-dimer transitions of mitochondrial creatine kinase in heart disease. J Mol Cell Cardiol 31(4):857\u2013866. https:\/\/doi.org\/10.1006\/jmcc.1998.0925","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"20_CR348","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1026163921643","volume":"17","author":"WC Stanley","year":"2003","unstructured":"Stanley WC, Kivilo KM, Panchal AR, Hallowell PH, Bomont C, Kasumov T, Brunengraber H (2003) Post-ischemic treatment with dipyruvyl-acetyl-glycerol decreases myocardial infarct size in the pig. Cardiovasc Drugs Ther 17(3):209\u2013216","journal-title":"Cardiovasc Drugs Ther"},{"issue":"2","key":"20_CR349","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1084\/jem.20032053","volume":"200","author":"IG Stavrovskaya","year":"2004","unstructured":"Stavrovskaya IG, Narayanan MV, Zhang W, Krasnikov BF, Heemskerk J, Young SS, Blass JP, Brown AM, Beal MF, Friedlander RM, Kristal BS (2004) Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology. J Exp Med 200(2):211\u2013222. https:\/\/doi.org\/10.1084\/jem.20032053","journal-title":"J Exp Med"},{"issue":"1","key":"20_CR350","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/01.RES.72.1.112","volume":"72","author":"C Steenbergen","year":"1993","unstructured":"Steenbergen C, Perlman ME, London RE, Murphy E (1993) Mechanism of preconditioning. Ionic alterations. Circ Res 72(1):112\u2013125","journal-title":"Circ Res"},{"issue":"1","key":"20_CR351","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/bip.21306","volume":"93","author":"AC Stelzer","year":"2010","unstructured":"Stelzer AC, Frazee RW, Van Huis C, Cleary J, Opipari AW Jr, Glick GD, Al-Hashimi HM (2010) NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. Biopolymers 93(1):85\u201392. https:\/\/doi.org\/10.1002\/bip.21306","journal-title":"Biopolymers"},{"issue":"3","key":"20_CR352","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1161\/01.RES.0000202707.79018.0a","volume":"98","author":"J Sun","year":"2006","unstructured":"Sun J, Picht E, Ginsburg KS, Bers DM, Steenbergen C, Murphy E (2006a) Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia\/reperfusion injury. Circ Res 98(3):403\u2013411. https:\/\/doi.org\/10.1161\/01.RES.0000202707.79018.0a","journal-title":"Circ Res"},{"issue":"9\u201310","key":"20_CR353","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1089\/ars.2006.8.1693","volume":"8","author":"J Sun","year":"2006","unstructured":"Sun J, Steenbergen C, Murphy E (2006b) S-Nitrosylation: NO-related redox signaling to protect against oxidative stress. Antioxid Redox Signal 8(9\u201310):1693\u20131705. https:\/\/doi.org\/10.1089\/ars.2006.8.1693","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"20_CR354","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1161\/CIRCRESAHA.107.155879","volume":"101","author":"J Sun","year":"2007","unstructured":"Sun J, Morgan M, Shen RF, Steenbergen C, Murphy E (2007) Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport. Circ Res 101(11):1155\u20131163. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.155879","journal-title":"Circ Res"},{"issue":"3","key":"20_CR355","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.biopha.2009.09.024","volume":"64","author":"Y Sun","year":"2010","unstructured":"Sun Y, Deng T, Lu N, Yan M, Zheng X (2010) B-type natriuretic peptide protects cardiomyocytes at reperfusion via mitochondrial calcium uniporter. Biomed Pharmacother 64(3):170\u2013176. https:\/\/doi.org\/10.1016\/j.biopha.2009.09.024","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"20_CR356","doi-asserted-by":"publisher","first-page":"262 e263","DOI":"10.1016\/j.cjca.2010.12.023","volume":"27","author":"S Surinkaew","year":"2011","unstructured":"Surinkaew S, Chattipakorn S, Chattipakorn N (2011) Roles of mitochondrial benzodiazepine receptor in the heart. Can J Cardiol 27(2):262 e263\u2013262 e213. https:\/\/doi.org\/10.1016\/j.cjca.2010.12.023","journal-title":"Can J Cardiol"},{"issue":"2","key":"20_CR357","doi-asserted-by":"publisher","first-page":"E277","DOI":"10.1208\/aapsj080232","volume":"8","author":"HH Szeto","year":"2006","unstructured":"Szeto HH (2006) Cell-permeable, mitochondrial-targeted, peptide antioxidants. AAPS J 8(2):E277\u2013E283. https:\/\/doi.org\/10.1208\/aapsj080232","journal-title":"AAPS J"},{"issue":"3","key":"20_CR358","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1089\/ars.2007.1892","volume":"10","author":"HH Szeto","year":"2008","unstructured":"Szeto HH (2008) Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. Antioxid Redox Signal 10(3):601\u2013619. https:\/\/doi.org\/10.1089\/ars.2007.1892","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"20_CR359","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1007\/s11095-011-0476-8","volume":"28","author":"HH Szeto","year":"2011","unstructured":"Szeto HH, Schiller PW (2011) Novel therapies targeting inner mitochondrial membrane\u2014from discovery to clinical development. Pharm Res 28(11):2669\u20132679. https:\/\/doi.org\/10.1007\/s11095-011-0476-8","journal-title":"Pharm Res"},{"issue":"1","key":"20_CR360","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1038\/s41598-017-07272-y","volume":"7","author":"J Teixeira","year":"2017","unstructured":"Teixeira J, Oliveira C, Ricardo A, Cagide F, Garrido J, Ribeiro JA, Pereira CM, Silva AF, Andrade PB, Oliveira PJ, Borges F (2017) Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria. Sci Rep 7(1):6842","journal-title":"Sci Rep"},{"issue":"18","key":"20_CR361","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1161\/01.CIR.0000093277.20968.C7","volume":"108","author":"Y Teshima","year":"2003","unstructured":"Teshima Y, Akao M, Jones SP, Marban E (2003) Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 108(18):2275\u20132281. https:\/\/doi.org\/10.1161\/01.CIR.0000093277.20968.C7","journal-title":"Circulation"},{"issue":"25","key":"20_CR362","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.102.25.3032","volume":"102","author":"P Theroux","year":"2000","unstructured":"Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS, Tognoni G, White HD, Willerson JT, Jessel A (2000) Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators. Circulation 102(25):3032\u20133038","journal-title":"Circulation"},{"issue":"4","key":"20_CR363","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.87.4.309","volume":"87","author":"H Tong","year":"2000","unstructured":"Tong H, Chen W, Steenbergen C, Murphy E (2000) Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res 87(4):309\u2013315","journal-title":"Circ Res"},{"issue":"4","key":"20_CR364","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/01.RES.0000012567.95445.55","volume":"90","author":"H Tong","year":"2002","unstructured":"Tong H, Imahashi K, Steenbergen C, Murphy E (2002) Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase-dependent pathway is cardioprotective. Circ Res 90(4):377\u2013379","journal-title":"Circ Res"},{"issue":"3","key":"20_CR365","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00005344-199423030-00002","volume":"23","author":"A Tosaki","year":"1994","unstructured":"Tosaki A, Cordis GA, Szerdahelyi P, Engelman RM, Das DK (1994) Effects of preconditioning on reperfusion arrhythmias, myocardial functions, formation of free radicals, and ion shifts in isolated ischemic\/reperfused rat hearts. J Cardiovasc Pharmacol 23(3):365\u2013373","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"20_CR366","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.gene.2015.11.052","volume":"577","author":"RE Turnham","year":"2016","unstructured":"Turnham RE, Scott JD (2016) Protein kinase A catalytic subunit isoform PRKACA; history, function and physiology. Gene 577(2):101\u2013108. https:\/\/doi.org\/10.1016\/j.gene.2015.11.052","journal-title":"Gene"},{"key":"20_CR367","doi-asserted-by":"publisher","unstructured":"Turrell HE, Thaitirarot C, Crumbie H, Rodrigo G (2014) Remote ischemic preconditioning of cardiomyocytes inhibits the mitochondrial permeability transition pore independently of reduced calcium-loading or sarcKATP channel activation. Physiol Rep 2(11). https:\/\/doi.org\/10.14814\/phy2.12231","DOI":"10.14814\/phy2.12231"},{"issue":"2","key":"20_CR368","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","volume":"27","author":"G Twig","year":"2008","unstructured":"Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27(2):433\u2013446. https:\/\/doi.org\/10.1038\/sj.emboj.7601963","journal-title":"EMBO J"},{"issue":"1","key":"20_CR369","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.mito.2011.04.006","volume":"12","author":"P Varanyuwatana","year":"2012","unstructured":"Varanyuwatana P, Halestrap AP (2012) The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore. Mitochondrion 12(1):120\u2013125. https:\/\/doi.org\/10.1016\/j.mito.2011.04.006","journal-title":"Mitochondrion"},{"issue":"7","key":"20_CR370","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.cell.2012.05.014","volume":"149","author":"AV Vaseva","year":"2012","unstructured":"Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM (2012) p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149(7):1536\u20131548. https:\/\/doi.org\/10.1016\/j.cell.2012.05.014","journal-title":"Cell"},{"issue":"23","key":"20_CR371","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.2174\/138161207781368710","volume":"13","author":"L Veenman","year":"2007","unstructured":"Veenman L, Papadopoulos V, Gavish M (2007) Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des 13(23):2385\u20132405","journal-title":"Curr Pharm Des"},{"issue":"3","key":"20_CR372","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10863-008-9142-1","volume":"40","author":"L Veenman","year":"2008","unstructured":"Veenman L, Shandalov Y, Gavish M (2008) VDAC activation by the 18\u00a0kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr 40(3):199\u2013205. https:\/\/doi.org\/10.1007\/s10863-008-9142-1","journal-title":"J Bioenerg Biomembr"},{"issue":"4","key":"20_CR373","doi-asserted-by":"publisher","first-page":"H1237","DOI":"10.1152\/ajpheart.00840.2010","volume":"300","author":"MC Villa-Abrille","year":"2011","unstructured":"Villa-Abrille MC, Cingolani E, Cingolani HE, Alvarez BV (2011) Silencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening. Am J Physiol Heart Circ Physiol 300(4):H1237\u2013H1251. https:\/\/doi.org\/10.1152\/ajpheart.00840.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"20_CR374","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.1074\/jbc.C114.629766","volume":"290","author":"S Stockum von","year":"2015","unstructured":"von Stockum S, Giorgio V, Trevisan E, Lippe G, Glick GD, Forte MA, Da-Re C, Checchetto V, Mazzotta G, Costa R, Szabo I, Bernardi P (2015) F-ATPase of Drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. J Biol Chem 290(8):4537\u20134544. https:\/\/doi.org\/10.1074\/jbc.C114.629766","journal-title":"J Biol Chem"},{"issue":"1","key":"20_CR375","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1124\/mol.62.1.22","volume":"62","author":"PC Waldmeier","year":"2002","unstructured":"Waldmeier PC, Feldtrauer JJ, Qian T, Lemasters JJ (2002) Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol 62(1):22\u201329","journal-title":"Mol Pharmacol"},{"issue":"4","key":"20_CR376","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1021\/acschembio.6b01129","volume":"12","author":"JR Walker","year":"2017","unstructured":"Walker JR, Hall MP, Zimprich CA, Robers MB, Duellman SJ, Machleidt T, Rodriguez J, Zhou W (2017) Highly potent cell-permeable and impermeable NanoLuc luciferase inhibitors. ACS Chem Biol 12(4):1028\u20131037. https:\/\/doi.org\/10.1021\/acschembio.6b01129","journal-title":"ACS Chem Biol"},{"issue":"5","key":"20_CR377","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s00726-011-0877-3","volume":"40","author":"T Wallimann","year":"2011","unstructured":"Wallimann T, Tokarska-Schlattner M, Schlattner U (2011) The creatine kinase system and pleiotropic effects of creatine. Amino Acids 40(5):1271\u20131296. https:\/\/doi.org\/10.1007\/s00726-011-0877-3","journal-title":"Amino Acids"},{"issue":"5","key":"20_CR378","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.ejcts.2008.07.062","volume":"34","author":"SR Walsh","year":"2008","unstructured":"Walsh SR, Tang TY, Kullar P, Jenkins DP, Dutka DP, Gaunt ME (2008) Ischaemic preconditioning during cardiac surgery: systematic review and meta-analysis of perioperative outcomes in randomised clinical trials. Eur J Cardiothorac Surg 34(5):985\u2013994. https:\/\/doi.org\/10.1016\/j.ejcts.2008.07.062","journal-title":"Eur J Cardiothorac Surg"},{"issue":"5","key":"20_CR379","doi-asserted-by":"crossref","first-page":"H2321","DOI":"10.1152\/ajpheart.2001.280.5.H2321","volume":"280","author":"L Wang","year":"2001","unstructured":"Wang L, Cherednichenko G, Hernandez L, Halow J, Camacho SA, Figueredo V, Schaefer S (2001) Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels. Am J Physiol Heart Circ Physiol 280(5):H2321\u2013H2328","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"20_CR380","doi-asserted-by":"publisher","first-page":"H1290","DOI":"10.1152\/ajpheart.00796.2004","volume":"288","author":"G Wang","year":"2005","unstructured":"Wang G, Liem DA, Vondriska TM, Honda HM, Korge P, Pantaleon DM, Qiao X, Wang Y, Weiss JN, Ping P (2005) Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am J Physiol Heart Circ Physiol 288(3):H1290\u2013H1295. https:\/\/doi.org\/10.1152\/ajpheart.00796.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"20_CR381","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.cell.2008.06.017","volume":"134","author":"W Wang","year":"2008","unstructured":"Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H (2008) Superoxide flashes in single mitochondria. Cell 134(2):279\u2013290. https:\/\/doi.org\/10.1016\/j.cell.2008.06.017","journal-title":"Cell"},{"issue":"19","key":"20_CR382","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1161\/CIRCULATIONAHA.108.791533","volume":"118","author":"MB West","year":"2008","unstructured":"West MB, Rokosh G, Obal D, Velayutham M, Xuan YT, Hill BG, Keith RJ, Schrader J, Guo Y, Conklin DJ, Prabhu SD, Zweier JL, Bolli R, Bhatnagar A (2008) Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia\/reperfusion injury by preventing mitochondrial permeability transition. Circulation 118(19):1970\u20131978. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.108.791533","journal-title":"Circulation"},{"issue":"4","key":"20_CR383","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.07.121","volume":"322","author":"BJ Wilkins","year":"2004","unstructured":"Wilkins BJ, Molkentin JD (2004) Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322(4):1178\u20131191. https:\/\/doi.org\/10.1016\/j.bbrc.2004.07.121","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"20_CR384","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0006-3495(82)84577-3","volume":"37","author":"JE Wilson","year":"1982","unstructured":"Wilson JE (1982) \u201cAmbiquitous\u201d behavior of brain hexokinase: rapid and reversible interaction of hexokinase with the outer mitochondrial membrane. Biophys J 37(1):18\u201319. https:\/\/doi.org\/10.1016\/S0006-3495(82)84577-3","journal-title":"Biophys J"},{"issue":"4","key":"20_CR385","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1529\/biophysj.104.054528","volume":"88","author":"JD Wilson","year":"2005","unstructured":"Wilson JD, Bigelow CE, Calkins DJ, Foster TH (2005) Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling. Biophys J 88(4):2929\u20132938. https:\/\/doi.org\/10.1529\/biophysj.104.054528","journal-title":"Biophys J"},{"issue":"3","key":"20_CR386","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/01.CIR.87.3.881","volume":"87","author":"CL Wolfe","year":"1993","unstructured":"Wolfe CL, Sievers RE, Visseren FL, Donnelly TJ (1993) Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 87(3):881\u2013892","journal-title":"Circulation"},{"key":"20_CR387","doi-asserted-by":"publisher","first-page":"e3196","DOI":"10.7717\/peerj.3196","volume":"5","author":"J Wu","year":"2017","unstructured":"Wu J, Yu J, Xie P, Maimaitili Y, Wang J, Yang L, Ma H, Zhang X, Yang Y, Zheng H (2017) Sevoflurane postconditioning protects the myocardium against ischemia\/reperfusion injury via activation of the JAK2-STAT3 pathway. Peer J 5:e3196. https:\/\/doi.org\/10.7717\/peerj.3196","journal-title":"Peer J"},{"issue":"1\u20133","key":"20_CR388","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ejphar.2008.12.024","volume":"604","author":"J Xi","year":"2009","unstructured":"Xi J, Wang H, Mueller RA, Norfleet EA, Xu Z (2009) Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore. Eur J Pharmacol 604(1\u20133):111\u2013116. https:\/\/doi.org\/10.1016\/j.ejphar.2008.12.024","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"20_CR389","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.RES.85.8.723","volume":"85","author":"XH Xiao","year":"1999","unstructured":"Xiao XH, Allen DG (1999) Role of Na(+)\/H(+) exchanger during ischemia and preconditioning in the isolated rat heart. Circ Res 85(8):723\u2013730","journal-title":"Circ Res"},{"issue":"2","key":"20_CR390","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0008-6363(00)00166-8","volume":"48","author":"XH Xiao","year":"2000","unstructured":"Xiao XH, Allen DG (2000) Activity of the Na(+)\/H(+) exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart. Cardiovasc Res 48(2):244\u2013253","journal-title":"Cardiovasc Res"},{"issue":"4","key":"20_CR391","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1258\/ebm.2009.009291","volume":"235","author":"J Xiao","year":"2010","unstructured":"Xiao J, Liang D, Zhang H, Liu Y, Li F, Chen YH (2010) 4\u2032-Chlorodiazepam, a translocator protein (18\u00a0kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats. Exp Biol Med (Maywood) 235(4):478\u2013486. https:\/\/doi.org\/10.1258\/ebm.2009.009291","journal-title":"Exp Biol Med (Maywood)"},{"key":"20_CR392","doi-asserted-by":"publisher","first-page":"5141","DOI":"10.12659\/msm.898980","volume":"22","author":"G Xing","year":"2016","unstructured":"Xing G, Luo Z, Zhong C, Pan X, Xu X (2016) Influence of miR-155 on cell apoptosis in rats with ischemic stroke: role of the ras homolog enriched in brain (Rheb)\/mTOR pathway. Med Sci Monit 22:5141\u20135153. https:\/\/doi.org\/10.12659\/msm.898980","journal-title":"Med Sci Monit"},{"issue":"2","key":"20_CR393","doi-asserted-by":"crossref","first-page":"H899","DOI":"10.1152\/ajpheart.2001.280.2.H899","volume":"280","author":"M Xu","year":"2001","unstructured":"Xu M, Wang Y, Hirai K, Ayub A, Ashraf M (2001) Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis. Am J Physiol Heart Circ Physiol 280(2):H899\u2013H908","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"20_CR394","doi-asserted-by":"publisher","first-page":"13189","DOI":"10.1038\/ncomms13189","volume":"7","author":"S Xu","year":"2016","unstructured":"Xu S, Wang P, Zhang H, Gong G, Gutierrez Cortes N, Zhu W, Yoon Y, Tian R, Wang W (2016) CaMKII induces permeability transition through Drp1 phosphorylation during chronic beta-AR stimulation. Nat Commun 7:13189. https:\/\/doi.org\/10.1038\/ncomms13189","journal-title":"Nat Commun"},{"issue":"5","key":"20_CR395","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.3892\/mmr.2016.5005","volume":"13","author":"K Yan","year":"2016","unstructured":"Yan K, Gao LN, Cui YL, Zhang Y, Zhou X (2016) The cyclic AMP signaling pathway: exploring targets for successful drug discovery (review). Mol Med Rep 13(5):3715\u20133723. https:\/\/doi.org\/10.3892\/mmr.2016.5005","journal-title":"Mol Med Rep"},{"issue":"3","key":"20_CR396","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10557-010-6236-x","volume":"24","author":"X Yang","year":"2010","unstructured":"Yang X, Cohen MV, Downey JM (2010) Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther 24(3):225\u2013234. https:\/\/doi.org\/10.1007\/s10557-010-6236-x","journal-title":"Cardiovasc Drugs Ther"},{"issue":"20","key":"20_CR397","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1021\/bi00234a016","volume":"30","author":"WL Ying","year":"1991","unstructured":"Ying WL, Emerson J, Clarke MJ, Sanadi DR (1991) Inhibition of mitochondrial calcium ion transport by an oxo-bridged dinuclear ruthenium ammine complex. Biochemistry 30(20):4949\u20134952","journal-title":"Biochemistry"},{"issue":"3 Pt 2","key":"20_CR398","first-page":"H1145","volume":"266","author":"K Ytrehus","year":"1994","unstructured":"Ytrehus K, Liu Y, Downey JM (1994) Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Phys 266(3 Pt 2):H1145\u2013H1152","journal-title":"Am J Phys"},{"issue":"8","key":"20_CR399","doi-asserted-by":"publisher","first-page":"e0134666","DOI":"10.1371\/journal.pone.0134666","volume":"10","author":"P Yu","year":"2015","unstructured":"Yu P, Zhang J, Yu S, Luo Z, Hua F, Yuan L, Zhou Z, Liu Q, Du X, Chen S, Zhang L, Xu G (2015) Protective effect of sevoflurane postconditioning against cardiac ischemia\/reperfusion injury via ameliorating mitochondrial impairment, oxidative stress and rescuing autophagic clearance. PLoS One 10(8):e0134666. https:\/\/doi.org\/10.1371\/journal.pone.0134666","journal-title":"PLoS One"},{"key":"20_CR400","doi-asserted-by":"publisher","first-page":"e2659","DOI":"10.7717\/peerj.2659","volume":"4","author":"J Yu","year":"2016","unstructured":"Yu J, Wu J, Xie P, Maimaitili Y, Wang J, Xia Z, Gao F, Zhang X, Zheng H (2016) Sevoflurane postconditioning attenuates cardiomyocyte hypoxia\/reoxygenation injury via restoring mitochondrial morphology. Peer J 4:e2659. https:\/\/doi.org\/10.7717\/peerj.2659","journal-title":"Peer J"},{"issue":"1","key":"20_CR401","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0005-2728(92)90022-T","volume":"1140","author":"G Yuan","year":"1992","unstructured":"Yuan G, Kaneko M, Masuda H, Hon RB, Kobayashi A, Yamazaki N (1992) Decrease in heart mitochondrial creatine kinase activity due to oxygen free radicals. Biochim Biophys Acta 1140(1):78\u201384","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"20_CR402","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/FJC.0000000000000071","volume":"63","author":"R Zepeda","year":"2014","unstructured":"Zepeda R, Kuzmicic J, Parra V, Troncoso R, Pennanen C, Riquelme JA, Pedrozo Z, Chiong M, Sanchez G, Lavandero S (2014) Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury. J Cardiovasc Pharmacol 63(6):477\u2013487. https:\/\/doi.org\/10.1097\/FJC.0000000000000071","journal-title":"J Cardiovasc Pharmacol"},{"issue":"6","key":"20_CR403","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0735-1097(01)01608-4","volume":"38","author":"U Zeymer","year":"2001","unstructured":"Zeymer U, Suryapranata H, Monassier JP, Opolski G, Davies J, Rasmanis G, Linssen G, Tebbe U, Schroder R, Tiemann R, Machnig T, Neuhaus KL, Investigators E (2001) The Na(+)\/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol 38(6):1644\u20131650","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"20_CR404","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.lfs.2005.05.076","volume":"78","author":"SZ Zhang","year":"2006","unstructured":"Zhang SZ, Gao Q, Cao CM, Bruce IC, Xia Q (2006) Involvement of the mitochondrial calcium uniporter in cardioprotection by ischemic preconditioning. Life Sci 78(7):738\u2013745. https:\/\/doi.org\/10.1016\/j.lfs.2005.05.076","journal-title":"Life Sci"},{"issue":"2","key":"20_CR405","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/cvr\/cvw212","volume":"113","author":"H Zhang","year":"2017","unstructured":"Zhang H, Wang P, Bisetto S, Yoon Y, Chen Q, Sheu SS, Wang W (2017) A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration. Cardiovasc Res 113(2):160\u2013170. https:\/\/doi.org\/10.1093\/cvr\/cvw212","journal-title":"Cardiovasc Res"},{"issue":"33","key":"20_CR406","doi-asserted-by":"publisher","first-page":"34682","DOI":"10.1074\/jbc.M402999200","volume":"279","author":"K Zhao","year":"2004","unstructured":"Zhao K, Zhao GM, Wu D, Soong Y, Birk AV, Schiller PW, Szeto HH (2004) Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem 279(33):34682\u201334690. https:\/\/doi.org\/10.1074\/jbc.M402999200","journal-title":"J Biol Chem"},{"key":"20_CR407","doi-asserted-by":"publisher","unstructured":"Zhou W, Marinelli F, Nief C, Faraldo-Gomez JD (2017) Atomistic simulations indicate the c-subunit ring of the F1Fo ATP synthase is not the mitochondrial permeability transition pore. Elife 6. https:\/\/doi.org\/10.7554\/eLife.23781","DOI":"10.7554\/eLife.23781"},{"issue":"5","key":"20_CR408","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF00762739","volume":"26","author":"M Zoratti","year":"1994","unstructured":"Zoratti M, Szabo I (1994) Electrophysiology of the inner mitochondrial membrane. J Bioenerg Biomembr 26(5):543\u2013553","journal-title":"J Bioenerg Biomembr"},{"issue":"6","key":"20_CR409","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.bbadis.2014.10.016","volume":"1852","author":"BN Zordoky","year":"2015","unstructured":"Zordoky BN, Robertson IM, Dyck JR (2015) Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochim Biophys Acta 1852(6):1155\u20131177. https:\/\/doi.org\/10.1016\/j.bbadis.2014.10.016","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"20_CR410","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/cvr\/cvp151","volume":"83","author":"DB Zorov","year":"2009","unstructured":"Zorov DB, Juhaszova M, Yaniv Y, Nuss HB, Wang S, Sollott SJ (2009) Regulation and pharmacology of the mitochondrial permeability transition pore. Cardiovasc Res 83(2):213\u2013225. https:\/\/doi.org\/10.1093\/cvr\/cvp151","journal-title":"Cardiovasc Res"},{"issue":"1","key":"20_CR411","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1684\/ecn.2013.0335","volume":"24","author":"FA Zouein","year":"2013","unstructured":"Zouein FA, Kurdi M, Booz GW (2013) LIF and the heart: just another brick in the wall? Eur Cytokine Netw 24(1):11\u201319. https:\/\/doi.org\/10.1684\/ecn.2013.0335","journal-title":"Eur Cytokine Netw"},{"issue":"1","key":"20_CR412","doi-asserted-by":"publisher","first-page":"H496","DOI":"10.1152\/ajpheart.01182.2004","volume":"289","author":"CJ Zuurbier","year":"2005","unstructured":"Zuurbier CJ, Eerbeek O, Meijer AJ (2005) Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution. Am J Physiol Heart Circ Physiol 289(1):H496\u2013H499. https:\/\/doi.org\/10.1152\/ajpheart.01182.2004","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Mitochondrial Biology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-73344-9_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:15:10Z","timestamp":1751494510000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-73344-9_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319733432","9783319733449"],"references-count":414,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-73344-9_20","relation":{},"subject":[],"published":{"date-parts":[[2018]]}}}