{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:21:45Z","timestamp":1751516505759,"version":"3.41.0"},"publisher-location":"Cham","reference-count":263,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319733432"},{"type":"electronic","value":"9783319733449"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-73344-9_7","type":"book-chapter","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T08:23:22Z","timestamp":1521620602000},"page":"91-126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mitochondria in Liver Diseases"],"prefix":"10.1007","author":[{"given":"Ignazio","family":"Grattagliano","sequence":"first","affiliation":[]},{"given":"Ornella","family":"de Bari","sequence":"additional","affiliation":[]},{"given":"Domenica","family":"Di Palo","sequence":"additional","affiliation":[]},{"given":"Fabrizio","family":"Montecucco","sequence":"additional","affiliation":[]},{"given":"Federico","family":"Carbone","sequence":"additional","affiliation":[]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"David Q.-H.","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"7_CR1","doi-asserted-by":"crossref","first-page":"17665","DOI":"10.1016\/S0021-9258(17)46753-6","volume":"268","author":"NA Abumrad","year":"1993","unstructured":"Abumrad NA, El-Maghrabi MR, Amri EZ, Lopez E, Grimaldi PA (1993) Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem 268:17665\u201317668","journal-title":"J Biol Chem"},{"key":"7_CR2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/CS20140732","volume":"129","author":"MB Afonso","year":"2015","unstructured":"Afonso MB, Rodrigues PM, Carvalho T, Caridade M, Borralho P, Cortez-Pinto H, Castro RE, Rodrigues CM (2015) Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. Clin Sci (Lond) 129:721\u2013739","journal-title":"Clin Sci (Lond)"},{"key":"7_CR3","doi-asserted-by":"crossref","first-page":"e2390","DOI":"10.1038\/cddis.2016.280","volume":"7","author":"MB Afonso","year":"2016","unstructured":"Afonso MB, Rodrigues PM, Simao AL, Ofengeim D, Carvalho T, Amaral JD, Gaspar MM, Cortez-Pinto H, Castro RE, Yuan J, Rodrigues CM (2016) Activation of necroptosis in human and experimental cholestasis. Cell Death Dis 7:e2390","journal-title":"Cell Death Dis"},{"key":"7_CR4","first-page":"82","volume":"30","author":"E Altomare","year":"1998","unstructured":"Altomare E, Grattagliano I, Didonna D, Gentile A, Vendemiale G (1998) Gastric and intestinal ethanol toxicity in the rat. Effect on glutathione level and role of alcohol and acetaldehyde metabolisms. Ital J Gastroenterol Hepatol 30:82\u201390","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"7_CR5","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/hep.510300604","volume":"30","author":"P Angulo","year":"1999","unstructured":"Angulo P, Keach JC, Batts KP, Lindor KD (1999) Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30:1356\u20131362","journal-title":"Hepatology"},{"key":"7_CR6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0035-1562947","volume":"35","author":"QM Anstee","year":"2015","unstructured":"Anstee QM, Day CP (2015) The genetics of nonalcoholic fatty liver disease: spotlight on PNPla3 and TM6SF2. Semin Liver Dis 35:270\u2013290","journal-title":"Semin Liver Dis"},{"key":"7_CR7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhep.2009.03.019","volume":"51","author":"CK Argo","year":"2009","unstructured":"Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH (2009) Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol 51:371\u2013379","journal-title":"J Hepatol"},{"key":"7_CR8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/abbi.1995.1231","volume":"318","author":"DR Arnelle","year":"1995","unstructured":"Arnelle DR, Stamler JS (1995) NO+, NO., and NO\u2212 donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. Arch Biochem Biophys 318:279\u2013285","journal-title":"Arch Biochem Biophys"},{"key":"7_CR9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bbagen.2008.09.004","volume":"1790","author":"P Arosio","year":"2009","unstructured":"Arosio P, Ingrassia R, Cavadini P (2009) Ferritins: a family of molecules for iron storage, antioxidation and more. Biochim Biophys Acta 1790:589\u2013599","journal-title":"Biochim Biophys Acta"},{"key":"7_CR10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/hep.1840050514","volume":"5","author":"BR Bacon","year":"1985","unstructured":"Bacon BR, Park CH, Brittenham GM, Tavill AS (1985) Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload. Hepatology 5:789\u2013797","journal-title":"Hepatology"},{"key":"7_CR11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0748-5514(86)80034-4","volume":"2","author":"BR Bacon","year":"1986","unstructured":"Bacon BR, O\u2019Neill R, Park CH (1986) Iron-induced peroxidative injury to isolated rat hepatic mitochondria. J Free Radic Biol Med 2:339\u2013347","journal-title":"J Free Radic Biol Med"},{"key":"7_CR12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/hep.1840090309","volume":"9","author":"BR Bacon","year":"1989","unstructured":"Bacon BR, Britton RS, O\u2019Neill R (1989) Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload. Hepatology 9:398\u2013404","journal-title":"Hepatology"},{"key":"7_CR13","doi-asserted-by":"crossref","first-page":"G857","DOI":"10.1152\/ajpgi.00044.2006","volume":"291","author":"SM Bailey","year":"2006","unstructured":"Bailey SM, Robinson G, Pinner A, Chamlee L, Ulasova E, Pompilius M, Page GP, Chhieng D, Jhala N, Landar A (2006) S-Adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. Am J Physiol Gastrointest Liver Physiol 291:G857\u2013G867","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"7_CR14","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1111\/j.1572-0241.1999.01294.x","volume":"94","author":"G Barbaro","year":"1999","unstructured":"Barbaro G, Di Lorenzo G, Asti A, Ribersani M, Belloni G, Grisorio B, Filice G, Barbarini G (1999) Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am J Gastroenterol 94:2198\u20132205","journal-title":"Am J Gastroenterol"},{"key":"7_CR15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1590-8658(01)80140-7","volume":"33","author":"G Barbaro","year":"2001","unstructured":"Barbaro G, Di Lorenzo G, Belloni G, Asti A, Pellicelli A, Barbarini G (2001) Hepatic iron storage and megamitochondria formation in patients with chronic hepatitis C related to the hepatitis C virus genotype. Dig Liver Dis 33:81\u201383","journal-title":"Dig Liver Dis"},{"key":"7_CR16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1079\/BJN19900142","volume":"63","author":"C Bates","year":"1990","unstructured":"Bates C (1990) Liberation of CO2 from [C] adipic acid and [C] octanoic acid by adult rats during riboflavin deficiency and its reversal. Br J Nutr 63:553\u2013562","journal-title":"Br J Nutr"},{"key":"7_CR17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.20734","volume":"42","author":"G Bedogni","year":"2005","unstructured":"Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S (2005) Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42:44\u201352","journal-title":"Hepatology"},{"key":"7_CR18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.taap.2008.03.017","volume":"231","author":"EA Belyaeva","year":"2008","unstructured":"Belyaeva EA, Dymkowska D, Wi\u0119ckowski MR, Wojtczak L (2008) Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol Appl Pharmacol 231:34\u201342","journal-title":"Toxicol Appl Pharmacol"},{"key":"7_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cld.2015.10.007","volume":"20","author":"PD Berk","year":"2016","unstructured":"Berk PD, Verna EC (2016) Nonalcoholic fatty liver disease. Clin Liver Dis 20:245\u2013262","journal-title":"Clin Liver Dis"},{"key":"7_CR20","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1073\/pnas.87.9.3484","volume":"87","author":"PD Berk","year":"1990","unstructured":"Berk PD, Wada H, Horio Y, Potter BJ, Sorrentino D, Zhou SL, Isola LM, Stump D, Kiang CL, Thung S (1990) Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related. Proc Natl Acad Sci U S A 87:3484\u20133488","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7_CR21","doi-asserted-by":"crossref","first-page":"8830","DOI":"10.1074\/jbc.272.13.8830","volume":"272","author":"PD Berk","year":"1997","unstructured":"Berk PD, Zhou SL, Kiang CL, Stump D, Bradbury M, Isola LM (1997) Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. J Biol Chem 272:8830\u20138835","journal-title":"J Biol Chem"},{"key":"7_CR22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0016-5085(98)70590-6","volume":"114","author":"A Berson","year":"1998","unstructured":"Berson A, De Beco V, Lett\u00e9ron P, Robin MA, Moreau C, El Kahwaji J, Verthier N, Feldmann G, Fromenty B, Pessayre D (1998) Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 114:764\u2013774","journal-title":"Gastroenterology"},{"key":"7_CR23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/hep.1840130313","volume":"13","author":"G Bianchi","year":"1991","unstructured":"Bianchi G, Marchesini G, Vilstrup H, Fabbri A, De Mitri MS, Zoli M, Pisi\u00e9l E (1991) Hepatic amino-nitrogen clearance to urea-nitrogen in control subjects and in patients with cirrhosis: a simplified method. Hepatology 13:460\u2013466","journal-title":"Hepatology"},{"key":"7_CR24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bpg.2014.07.013","volume":"28","author":"L Bonfrate","year":"2014","unstructured":"Bonfrate L, Wang DQ, Garruti G, Portincasa P (2014) Obesity and the risk and prognosis of gallstone disease and pancreatitis. Best Pract Res Clin Gastroenterol 28:623\u2013635","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"7_CR25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/gastro\/gou068","volume":"3","author":"L Bonfrate","year":"2015","unstructured":"Bonfrate L, Grattagliano I, Palasciano G, Portincasa P (2015) Dynamic carbon 13 breath tests for the study of liver function and gastric emptying. Gastroenterol Rep (Oxf) 3:12\u201321","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"7_CR26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.12688\/f1000research.10397.1","volume":"6","author":"RK Boyapati","year":"2017","unstructured":"Boyapati RK, Tamborska A, Dorward DA, Ho GT (2017) Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases. F1000Res 6:169","journal-title":"F1000Res"},{"key":"7_CR27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1569-2558(03)33004-8","volume":"33","author":"MW Bradbury","year":"2003","unstructured":"Bradbury MW, Berk PD (2003) Cellular uptake of long chain free fatty acids: the structure and function of plasma membrane fatty acid binding protein. Adv Mol Cell Biol 33:47\u201380","journal-title":"Adv Mol Cell Biol"},{"key":"7_CR28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jmb.2011.07.034","volume":"412","author":"MW Bradbury","year":"2011","unstructured":"Bradbury MW, Stump D, Guarnieri F, Berk PD (2011) Molecular modeling and functional confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase. J Mol Biol 412:412\u2013422","journal-title":"J Mol Biol"},{"key":"7_CR29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/hep.1840110116","volume":"11","author":"RS Britton","year":"1990","unstructured":"Britton RS, O\u2019Neill R, Bacon BR (1990) Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 11:93\u201397","journal-title":"Hepatology"},{"key":"7_CR30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/0016-5085(91)90543-T","volume":"101","author":"RS Britton","year":"1991","unstructured":"Britton RS, O\u2019Neill R, Bacon BR (1991) Chronic dietary iron overload in rats results in impaired calcium sequestration by hepatic mitochondria and microsomes 1, 2, and 3. Gastroenterology 101:806\u2013811","journal-title":"Gastroenterology"},{"key":"7_CR31","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1572-0241.2004.04059.x","volume":"99","author":"JD Browning","year":"2004","unstructured":"Browning JD, Kumar KS, Saboorian MH, Thiele DL (2004) Ethnic differences in the prevalence of cryptogenic cirrhosis. Am J Gastroenterol 99:292\u2013298","journal-title":"Am J Gastroenterol"},{"key":"7_CR32","doi-asserted-by":"crossref","first-page":"15080","DOI":"10.1038\/nrdp.2015.80","volume":"1","author":"EM Brunt","year":"2015","unstructured":"Brunt EM, Wong VW, Nobili V, Day CP, Sookoian S, Maher JJ, Bugianesi E, Sirlin CB, Neuschwander-Tetri BA, Rinella ME (2015) Nonalcoholic fatty liver disease. Nat Rev Dis Primers 1:15080","journal-title":"Nat Rev Dis Primers"},{"key":"7_CR33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/gast.2002.34168","volume":"123","author":"E Bugianesi","year":"2002","unstructured":"Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, De Paolis P, Capussotti L, Salizzoni M (2002) Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123:134\u2013140","journal-title":"Gastroenterology"},{"key":"7_CR34","first-page":"246","volume":"15","author":"AD Burt","year":"1998","unstructured":"Burt AD, Mutton A, Day CP (1998) Diagnosis and interpretation of steatosis and steatohepatitis. SeminDiagnPathol 15:246\u2013258","journal-title":"SeminDiagnPathol"},{"key":"7_CR35","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/978-1-59745-242-7_25","volume":"447","author":"A Cahill","year":"2008","unstructured":"Cahill A, Sykora P (2008) Alcoholic liver disease and the mitochondrial ribosome: methods of analysis. Methods Mol Biol 447:381\u2013394","journal-title":"Methods Mol Biol"},{"key":"7_CR36","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1517\/14728222.11.9.1231","volume":"11","author":"G Calamita","year":"2007","unstructured":"Calamita G, Portincasa P (2007) Present and future therapeutic strategies in non-alcoholic fatty liver disease. Expert Opin Ther Targets 11:1231\u20131249","journal-title":"Expert Opin Ther Targets"},{"key":"7_CR37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cld.2004.04.009","volume":"8","author":"SH Caldwell","year":"2004","unstructured":"Caldwell SH, Chang CY, Nakamoto RK, Krugner-Higby L (2004) Mitochondria in nonalcoholic fatty liver disease. Clin Liver Dis 8:595\u2013617","journal-title":"Clin Liver Dis"},{"key":"7_CR38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0076-6879(08)04420-0","volume":"456","author":"RV Campbell","year":"2009","unstructured":"Campbell RV, Yang Y, Wang T, Rachamallu A, Li Y, Watowich SJ, Weinman SA (2009) Effects of hepatitis C core protein on mitochondrial electron transport and production of reactive oxygen species. Methods Enzymol 456:363\u2013380","journal-title":"Methods Enzymol"},{"key":"7_CR39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/hep.20255","volume":"40","author":"MC Carreras","year":"2004","unstructured":"Carreras MC, Converso DP, Lorenti AS, Barbich M, Levisman DM, Jaitovich A, Antico Arciuch VG, Galli S, Poderoso JJ (2004) Mitochondrial nitric oxide synthase drives redox signals for proliferation and quiescence in rat liver development. Hepatology 40:157\u2013166","journal-title":"Hepatology"},{"key":"7_CR40","doi-asserted-by":"crossref","first-page":"39336","DOI":"10.1074\/jbc.M111.280420","volume":"286","author":"SC Cazanave","year":"2011","unstructured":"Cazanave SC, Mott JL, Bronk SF, Werneburg NW, Fingas CD, Meng XW, Finnberg N, El-Deiry WS, Kaufmann SH, Gores GJ (2011) Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem 286:39336\u201339348","journal-title":"J Biol Chem"},{"key":"7_CR41","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","volume":"142","author":"N Chalasani","year":"2012","unstructured":"Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142:1592\u20131609","journal-title":"Gastroenterology"},{"key":"7_CR42","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1440-1827.1987.tb03057.x","volume":"37","author":"ES Chang","year":"1987","unstructured":"Chang ES (1987) Ultrastructural morphogenesis of mitochondria in alcoholic liver. Pathol Int 37:213\u2013224","journal-title":"Pathol Int"},{"key":"7_CR43","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1572-0241.2006.01039.x","volume":"102","author":"M Charlton","year":"2007","unstructured":"Charlton M (2007) Noninvasive indices of fibrosis in NAFLD: starting to think about a three-hit (at least) phenomenon. Am J Gastroenterol 102:409\u2013411","journal-title":"Am J Gastroenterol"},{"key":"7_CR44","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/hep.20813","volume":"42","author":"T Chen","year":"2005","unstructured":"Chen T, Pearce LL, Peterson J, Stoyanovsky D, Billiar TR (2005) Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor\u2013mediated toxicity. Hepatology 42:598\u2013607","journal-title":"Hepatology"},{"key":"7_CR45","doi-asserted-by":"crossref","first-page":"23537","DOI":"10.1074\/jbc.M112.363960","volume":"287","author":"Z Chen","year":"2012","unstructured":"Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, Mcdonald WG, Colca JR, Kletzien RF, Finck BN (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor \u03b3-sparing thiazolidinedione. J Biol Chem 287:23537\u201323548","journal-title":"J Biol Chem"},{"key":"7_CR46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/clpt.2013.10","volume":"93","author":"JR Colca","year":"2013","unstructured":"Colca JR, Vanderlugt JT, Adams WJ, Shashlo A, Mcdonald WG, Liang J, Zhou R, Orloff DG (2013) Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizer. Clin Pharmacol Ther 93:352\u2013359","journal-title":"Clin Pharmacol Ther"},{"key":"7_CR47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hep4.1036","volume":"1","author":"JR Colca","year":"2017","unstructured":"Colca JR, Mcdonald WG, Mccommis KS, Finck BN (2017) Treating fatty liver disease by modulating mitochondrial pyruvate metabolism. Hepatol Commun 1:193\u2013197","journal-title":"Hepatol Commun"},{"key":"7_CR48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0005-2728(90)90136-R","volume":"1019","author":"WB Coleman","year":"1990","unstructured":"Coleman WB, Cunningham CC (1990) Effects of chronic ethanol consumption on the synthesis of polypeptides encoded by the hepatic mitochondrial genome. Biochim Biophys Acta 1019:142\u2013150","journal-title":"Biochim Biophys Acta"},{"key":"7_CR49","first-page":"245","volume":"2","author":"E Corradini","year":"2004","unstructured":"Corradini E, Ferrara F, Pietrangelo A (2004) Iron and the liver. Pediatr Endocrinol Rev 2:245\u2013248","journal-title":"Pediatr Endocrinol Rev"},{"key":"7_CR50","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1001\/jama.282.17.1659","volume":"282","author":"H Cortez-Pinto","year":"1999","unstructured":"Cortez-Pinto H, Chatham J, Chacko V, Arnold C, Rashid A, Diehl AM (1999) Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 282:1659\u20131664","journal-title":"JAMA"},{"key":"7_CR51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/cs0830183","volume":"83","author":"PC Dagnelie","year":"1992","unstructured":"Dagnelie PC, Menon DK, Cox IJ, Bell JD, Sargentoni J, Coutts GA, Urenjak J, Iles RA (1992) Effect of L-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo. Clin Sci 83:183\u2013190","journal-title":"Clin Sci"},{"key":"7_CR52","doi-asserted-by":"crossref","first-page":"10375","DOI":"10.1128\/JVI.00395-08","volume":"82","author":"L Deng","year":"2008","unstructured":"Deng L, Adachi T, Kitayama K, Bungyoku Y, Kitazawa S, Ishido S, Shoji I, Hotta H (2008) Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase 3-dependent pathway. J Virol 82:10375\u201310385","journal-title":"J Virol"},{"key":"7_CR53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11010-008-0003-3","volume":"326","author":"M Digel","year":"2009","unstructured":"Digel M, Ehehalt R, Stremmel W, Fullekrug J (2009) Acyl-CoA synthetases: fatty acid uptake and metabolic channeling. Mol Cell Biochem 326:23\u201328","journal-title":"Mol Cell Biochem"},{"key":"7_CR54","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.2174\/092986711798194432","volume":"18","author":"CV Diogo","year":"2011","unstructured":"Diogo CV, Grattagliano I, Oliveira PJ, Bonfrate L, Portincasa P (2011) Re-wiring the circuit: mitochondria as a pharmacological target in liver disease. Curr Med Chem 18:5448\u20135465","journal-title":"Curr Med Chem"},{"key":"7_CR55","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","volume":"115","author":"KL Donnelly","year":"2005","unstructured":"Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115:1343\u20131351","journal-title":"J Clin Invest"},{"key":"7_CR56","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/hep.1840150515","volume":"15","author":"JF Dufour","year":"1992","unstructured":"Dufour JF, Stoupis C, Lazeyras F, Vock P, Terrier F, Reichen J (1992) Alterations in hepatic fructose metabolism in cirrhotic patients demonstrated by dynamic 31phosphorus spectroscopy. Hepatology 15:835\u2013842","journal-title":"Hepatology"},{"key":"7_CR57","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","volume":"51","author":"E Fabbrini","year":"2010","unstructured":"Fabbrini E, Sullivan S, Klein S (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51:679\u2013689","journal-title":"Hepatology"},{"key":"7_CR58","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1093\/jn\/133.9.2707","volume":"133","author":"X Fan","year":"2003","unstructured":"Fan X, Bradbury MW, Berk PD (2003) Leptin and insulin modulate nutrient partitioning and weight loss in ob\/ob mice through regulation of long-chain fatty acid uptake by adipocytes. J Nutr 133:2707\u20132715","journal-title":"J Nutr"},{"key":"7_CR59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrgastro.2013.34","volume":"10","author":"GC Farrell","year":"2013","unstructured":"Farrell GC, Wong VW, Chitturi S (2013) NAFLD in Asia\u2014as common and important as in the West. Nat Rev Gastroenterol Hepatol 10:307\u2013318","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"7_CR60","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/hep.510310318","volume":"31","author":"G Feldmann","year":"2000","unstructured":"Feldmann G, Haouzi D, Moreau A, Durand-Schneider AM, Bringuier A, Berson A, Mansouri A, Fau D, Pessayre D (2000) Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in mice. Hepatology 31:674\u2013683","journal-title":"Hepatology"},{"key":"7_CR61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/febs.13120","volume":"282","author":"M Feoktistova","year":"2015","unstructured":"Feoktistova M, Leverkus M (2015) Programmed necrosis and necroptosis signalling. FEBS J 282:19\u201331","journal-title":"FEBS J"},{"key":"7_CR62","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1172\/JCI115010","volume":"87","author":"J Fernandez-Checa","year":"1991","unstructured":"Fernandez-Checa J, Garc\u00eda-Ruiz C, Ookhtens M, Kaplowitz N (1991) Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Investig 87:397","journal-title":"J Clin Investig"},{"key":"7_CR63","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-2007-1007172","volume":"18","author":"JC Fern\u00e1ndez-Checa","year":"1998","unstructured":"Fern\u00e1ndez-Checa JC, Kaplowitz N, Garc\u00eda-Ruiz C, Colell A (1998) Mitochondrial glutathione: importance and transport. Semin Liver Dis 18:389\u2013401","journal-title":"Semin Liver Dis"},{"key":"7_CR64","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/gut.2008.164335","volume":"58","author":"M Feuchtinger","year":"2009","unstructured":"Feuchtinger M, Christ S, Preuss B, Dengjel J, Duman S, Stevanovic S, Klein R (2009) Detection of novel non-M2-related antimitochondrial antibodies in patients with anti-M2 negative primary biliary cirrhosis. Gut 58:983\u2013989","journal-title":"Gut"},{"key":"7_CR65","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11901-014-0227-5","volume":"13","author":"CM Fielding","year":"2014","unstructured":"Fielding CM, Angulo P (2014) Hepatic steatosis and steatohepatitis: are they really two distinct entities? Curr Hepatol Rep 13:151\u2013158","journal-title":"Curr Hepatol Rep"},{"key":"7_CR66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/(SICI)1097-4652(200001)182:1<41::AID-JCP5>3.0.CO;2-7","volume":"182","author":"L Formigli","year":"2000","unstructured":"Formigli L, Papucci L, Tani A, Schiavone N, Tempestini A, Orlandini G, Capaccioli S, Zecchi Orlandini S (2000) Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. J Cell Physiol 182:41\u201349","journal-title":"J Cell Physiol"},{"key":"7_CR67","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.cgh.2012.06.019","volume":"10","author":"SM Francque","year":"2012","unstructured":"Francque SM, Verrijken A, Mertens I, Hubens G, Van Marck E, Pelckmans P, Michielsen P, Van Gaal L (2012) Noninvasive assessment of nonalcoholic fatty liver disease in obese or overweight patients. Clin Gastroenterol Hepatol 10:1162\u20138; quiz e87","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7_CR68","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0163-7258(95)00012-6","volume":"67","author":"B Fromenty","year":"1995","unstructured":"Fromenty B, Pessayre D (1995) Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 67:101\u2013154","journal-title":"Pharmacol Ther"},{"key":"7_CR69","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI83885","volume":"126","author":"I Garcia-Martinez","year":"2016","unstructured":"Garcia-Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, Shlomchik MJ, Coffman RL, Candia A, Mehal WZ (2016) Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest 126:859\u2013864","journal-title":"J Clin Invest"},{"key":"7_CR70","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1440-1746.2006.04570.x","volume":"21","author":"C Garcia-Ruiz","year":"2006","unstructured":"Garcia-Ruiz C, Fernandez-Checa JC (2006) Mitochondrial glutathione: hepatocellular survival\u2013death switch. J Gastroenterol Hepatol 21:S3\u2013S6","journal-title":"J Gastroenterol Hepatol"},{"key":"7_CR71","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/hep.21313","volume":"44","author":"I Garc\u00eda-Ruiz","year":"2006","unstructured":"Garc\u00eda-Ruiz I, Rodr\u00edguez-Juan C, D\u00edaz-Sanjuan T, Del Hoyo P, Colina F, Mu\u00f1oz-Yag\u00fce T, Sol\u00eds-Herruzo JA (2006) Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob\/ob mice. Hepatology 44:581\u2013591","journal-title":"Hepatology"},{"key":"7_CR72","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1242\/dmm.018234","volume":"8","author":"I Garcia-Ruiz","year":"2015","unstructured":"Garcia-Ruiz I, Solis-Munoz P, Fernandez-Moreira D, Munoz-Yague T, Solis-Herruzo JA (2015) In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis. Dis Model Mech 8:183\u2013191","journal-title":"Dis Model Mech"},{"key":"7_CR73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/bj1660039","volume":"166","author":"SJ Gatley","year":"1977","unstructured":"Gatley SJ, Sherratt H (1977) The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics. Biochem J 166:39\u201347","journal-title":"Biochem J"},{"key":"7_CR74","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.15252\/emmm.201403856","volume":"6","author":"J Gautheron","year":"2014","unstructured":"Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP (2014) A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol Med 6:1062\u20131074","journal-title":"EMBO Mol Med"},{"key":"7_CR75","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1258\/ebm.2010.010095","volume":"235","author":"F Ge","year":"2010","unstructured":"Ge F, Lobdell H IV, Zhou S, Hu C, Berk PD (2010a) Digital analysis of hepatic sections in mice accurately quantitates triglycerides and selected properties of lipid droplets. Exp Biol Med 235:1282\u20131286","journal-title":"Exp Biol Med"},{"key":"7_CR76","doi-asserted-by":"crossref","first-page":"G855","DOI":"10.1152\/ajpgi.00434.2009","volume":"299","author":"F Ge","year":"2010","unstructured":"Ge F, Zhou S, Hu C, Lobdell H, Berk PD (2010b) Insulin-and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob\/ob or db\/db mice. Am J Physiol Gastrointest Liver Physiol 299:G855\u2013G866","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"doi-asserted-by":"publisher","unstructured":"Ge F, Hu C, Hyodo E, Arai K, Zhou S, Lobdell H IV, Walewski JL, Homma S, Berk PD (2011) Cardiomyocyte triglyceride accumulation and reduced ventricular function in mice with obesity reflect increased long chain fatty acid uptake and de novo fatty acid synthesis. J Obes. https:\/\/doi.org\/10.1155\/2012\/205648","key":"7_CR77","DOI":"10.1155\/2012\/205648"},{"key":"7_CR78","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/oby.21249","volume":"24","author":"F Ge","year":"2016","unstructured":"Ge F, Walewski JL, Torghabeh MH, Lobdell HT, Hu C, Zhou S, Dakin G, Pomp A, Bessler M, Schrope B, Ude-Welcome A, Inabnet WB, Feng T, Carras-Terzian E, Anglade D, Ebel FE, Berk PD (2016) Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss. Obesity (Silver Spring) 24:113\u2013122","journal-title":"Obesity (Silver Spring)"},{"key":"7_CR79","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/jsre.1999.5620","volume":"86","author":"I Grattagliano","year":"1999","unstructured":"Grattagliano I, Vendemiale G, Lauterburg BH (1999) Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester. J Surg Res 86:2\u20138","journal-title":"J Surg Res"},{"key":"7_CR80","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1093\/jn\/130.9.2131","volume":"130","author":"I Grattagliano","year":"2000","unstructured":"Grattagliano I, Vendemiale G, Caraceni P, Domenicali M, Nardo B, Cavallari A, Trevisani F, Bernardi M, Altomare E (2000) Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet. J Nutr 130:2131\u20132136","journal-title":"J Nutr"},{"key":"7_CR81","first-page":"355","volume":"19","author":"I Grattagliano","year":"2003","unstructured":"Grattagliano I, Caraceni P, Portincasa P, Domenicali M, Palmieri VO, Trevisani F, Bernardi M, Palasciano G (2003) Adaptation of subcellular glutathione detoxification system to stress conditions in choline-deficient diet induced rat fatty liver. Cell BiolToxicol 19:355\u2013366","journal-title":"Cell BiolToxicol"},{"key":"7_CR82","first-page":"1323","volume":"39","author":"I Grattagliano","year":"2004","unstructured":"Grattagliano I, Portincasa P, Cocco T, Moschetta A, Di Paola M, Palmieri VO, Palasciano G (2004a) Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. ExpGerontol 39:1323\u20131332","journal-title":"ExpGerontol"},{"key":"7_CR83","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/hep.20208","volume":"39","author":"I Grattagliano","year":"2004","unstructured":"Grattagliano I, Russmann S, Palmieri VO, Juni P, Bihl F, Portincasa P, Palasciano G, Lauterburg BH (2004b) Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C. Hepatology 39:1248\u20131255","journal-title":"Hepatology"},{"key":"7_CR84","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/hep.21519","volume":"45","author":"I Grattagliano","year":"2007","unstructured":"Grattagliano I, Portincasa P, Palmieri VO, Palasciano G (2007) Mutual changes of thioredoxin and nitrosothiols during biliary cirrhosis: results from humans and cholestatic rats. Hepatology 45:331\u2013339","journal-title":"Hepatology"},{"key":"7_CR85","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2362.2008.01963.x","volume":"38","author":"I Grattagliano","year":"2008","unstructured":"Grattagliano I, Caraceni P, Calamita G, Ferri D, Gargano I, Palasciano G, Portincasa P (2008) Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Eur J Clin Investig 38:523\u2013530","journal-title":"Eur J Clin Investig"},{"key":"7_CR86","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2174\/138945011795528877","volume":"12","author":"I Grattagliano","year":"2011","unstructured":"Grattagliano I, Russmann S, Diogo C, Bonfrate L, Oliveira PJ, Wang DQ, Portincasa P (2011) Mitochondria in chronic liver disease. CurrDrug Targets 12:879\u2013893","journal-title":"CurrDrug Targets"},{"key":"7_CR87","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3748\/wjg.v19.i20.3007","volume":"19","author":"I Grattagliano","year":"2013","unstructured":"Grattagliano I, Diogo CV, Mastrodonato M, De Bari O, Persichella M, Wang DQ, Liquori A, Ferri D, Carratu MR, Oliveira PJ, Portincasa P (2013) A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes. World J Gastroenterol 19:3007\u20133017","journal-title":"World J Gastroenterol"},{"key":"7_CR88","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/ijo.2015.59","volume":"39","author":"F Greenway","year":"2015","unstructured":"Greenway F (2015) Physiological adaptations to weight loss and factors favouring weight regain. Int J Obes 39:1188\u20131196","journal-title":"Int J Obes"},{"key":"7_CR89","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0140-6736(00)02556-3","volume":"356","author":"M Gu","year":"2000","unstructured":"Gu M, Cooper J, Butler P, Walker A, Mistry P, Dooley J, Schapira A (2000) Oxidative-phosphorylation defects in liver of patients with Wilson\u2019s disease. Lancet 356:469\u2013474","journal-title":"Lancet"},{"key":"7_CR90","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/A:1005564031119","volume":"32","author":"F Guerrieri","year":"2000","unstructured":"Guerrieri F, Nicoletti C, Adorisio E, Caraccio G, Leonetti P, Zanotti F, Cantatore P (2000) Correlation between decreased expression of mitochondrial F0F1-ATP synthase and low regenerating capability of the liver after partial hepatectomy in hypothyroid rats. J Bioenerg Biomembr 32:183\u2013191","journal-title":"J Bioenerg Biomembr"},{"key":"7_CR91","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/hep.1840130502","volume":"13","author":"PD Hall","year":"1991","unstructured":"Hall PD, Plummer JL, Ilsley AH, Cousins MJ (1991) Hepatic fibrosis and cirrhosis after chronic administration of alcohol and \u201clow-dose\u201d carbon tetrachloride vapor in the rat. Hepatology 13:815\u2013819","journal-title":"Hepatology"},{"key":"7_CR92","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2337\/dc09-0148","volume":"33","author":"E Hamaguchi","year":"2010","unstructured":"Hamaguchi E, Takamura T, Sakurai M, Mizukoshi E, Zen Y, Takeshita Y, Kurita S, Arai K, Yamashita T, Sasaki M, Nakanuma Y, Kaneko S (2010) Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. Diabetes Care 33:284\u2013286","journal-title":"Diabetes Care"},{"key":"7_CR93","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0168-8278(92)90164-K","volume":"14","author":"O Hamberg","year":"1992","unstructured":"Hamberg O, Nielsen K, Vilstrup H (1992) Effects of an increase in protein intake on hepatic efficacy for urea synthesis in healthy subjects and in patients with cirrhosis. J Hepatol 14:237\u2013243","journal-title":"J Hepatol"},{"key":"7_CR94","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2016.11.020","volume":"102","author":"D Han","year":"2017","unstructured":"Han D, Johnson HS, Rao MP, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Casian JG, Cadenas E, Kaplowitz N (2017) Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radic Biol Med 102:100\u2013110","journal-title":"Free Radic Biol Med"},{"key":"7_CR95","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/jhep.2000.9034","volume":"32","author":"D Haouzi","year":"2000","unstructured":"Haouzi D, Lek\u00e9hal M, Moreau A, Moulis C, Feldmann G, Robin MA, Lett\u00e9ron P, Fau D, Pessayre D (2000) Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes. Hepatology 32:303\u2013311","journal-title":"Hepatology"},{"key":"7_CR96","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1053\/bega.2002.0325","volume":"16","author":"M Haque","year":"2002","unstructured":"Haque M, Sanyal AJ (2002) The metabolic abnormalities associated with non-alcoholic fatty liver disease. Best Pract Res Clin Gastroenterol 16:709\u2013731","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"7_CR97","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cgh.2014.11.024","volume":"13","author":"SA Harrison","year":"2015","unstructured":"Harrison SA (2015) Nonalcoholic fatty liver disease and fibrosis progression: the good, the bad, and the unknown. Clin Gastroenterol Hepatol 13:655\u2013657","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7_CR98","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/carcin\/21.5.983","volume":"21","author":"K Hensley","year":"2000","unstructured":"Hensley K, Kotake Y, Sang H, Pye QN, Wallis GL, Kolker LM, Tabatabaie T, Stewart CA, Konishi Y, Nakae D (2000) Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria. Carcinogenesis 21:983\u2013989","journal-title":"Carcinogenesis"},{"key":"7_CR99","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/hep.1840160619","volume":"16","author":"A Hirano","year":"1992","unstructured":"Hirano A, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC (1992) Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16:1423\u20131427","journal-title":"Hepatology"},{"key":"7_CR100","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.cgh.2009.06.007","volume":"7","author":"N Hossain","year":"2009","unstructured":"Hossain N, Afendy A, Stepanova M, Nader F, Srishord M, Rafiq N, Goodman Z, Younossi Z (2009) Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 7:1224\u20139, 1229 e1-2","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7_CR101","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1172\/JCI74068","volume":"124","author":"S Inokuchi-Shimizu","year":"2014","unstructured":"Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E (2014) TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124:3566\u20133578","journal-title":"J Clin Invest"},{"key":"7_CR102","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbagen.2009.04.009","volume":"1790","author":"HC Isom","year":"2009","unstructured":"Isom HC, Mcdevitt EI, Moon MS (2009) Elevated hepatic iron: a confounding factor in chronic hepatitis C. Biochim Biophys Acta 1790:650\u2013662","journal-title":"Biochim Biophys Acta"},{"key":"7_CR103","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/hep.1840090125","volume":"9","author":"Y Israel","year":"1989","unstructured":"Israel Y (1989) Covalent binding of acetaldehyde to liver tubulin: a step in the right direction. Hepatology 9:161\u2013162","journal-title":"Hepatology"},{"key":"7_CR104","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/0016-5085(91)90791-I","volume":"100","author":"S Iwata","year":"1991","unstructured":"Iwata S, Ozawa K, Shimahara Y, Mori K, Kobayashi N, Kumada K, Yamaoka Y (1991) Diurnal fluctuations of arterial ketone body ratio in normal subjects and patients with liver dysfunction. Gastroenterology 100:1371\u20131378","journal-title":"Gastroenterology"},{"key":"7_CR105","doi-asserted-by":"crossref","first-page":"8341286","DOI":"10.1155\/2017\/8341286","volume":"2017","author":"RN Jadeja","year":"2017","unstructured":"Jadeja RN, Devkar RV, Nammi S (2017) Oxidative stress in liver diseases: pathogenesis, prevention, and therapeutics. Oxidative Med Cell Longev 2017:8341286","journal-title":"Oxidative Med Cell Longev"},{"key":"7_CR106","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bpg.2009.02.004","volume":"23","author":"M Janssen","year":"2009","unstructured":"Janssen M, Swinkels D (2009) Hereditary haemochromatosis. Best Pract Res Clin Gastroenterol 23:171\u2013183","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"7_CR107","doi-asserted-by":"crossref","first-page":"14463","DOI":"10.1074\/jbc.M112.437210","volume":"288","author":"ES Johnson","year":"2013","unstructured":"Johnson ES, Lindblom KR, Robeson A, Stevens RD, Ilkayeva OR, Newgard CB, Kornbluth S, Andersen JL (2013) Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. J Biol Chem 288:14463\u201314475","journal-title":"J Biol Chem"},{"key":"7_CR108","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-0028-1091981","volume":"28","author":"J Jou","year":"2008","unstructured":"Jou J, Choi SS, Diehl AM (2008) Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis 28:370\u2013379","journal-title":"Semin Liver Dis"},{"key":"7_CR109","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2119\/2007-00114.Jouihan","volume":"14","author":"HA Jouihan","year":"2008","unstructured":"Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA (2008) Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med 14:98","journal-title":"Mol Med"},{"key":"7_CR110","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.freeradbiomed.2009.03.004","volume":"46","author":"VE Kagan","year":"2009","unstructured":"Kagan VE, Bay\u0131r HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM (2009) Cytochrome c\/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med 46:1439\u20131453","journal-title":"Free Radic Biol Med"},{"key":"7_CR111","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1572-0241.2000.01979.x","volume":"95","author":"F Kageyama","year":"2000","unstructured":"Kageyama F, Kobayashi Y, Kawasaki T, Toyokuni S, Uchida K, Nakamura H (2000) Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. Am J Gastroenterol 95:1041\u20131050","journal-title":"Am J Gastroenterol"},{"key":"7_CR112","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hep.1840160225","volume":"16","author":"S Kamimura","year":"1992","unstructured":"Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H (1992) Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology 16:448\u2013453","journal-title":"Hepatology"},{"key":"7_CR113","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI37007","volume":"119","author":"HL Kammoun","year":"2009","unstructured":"Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferre P, Foufelle F (2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119:1201\u20131215","journal-title":"J Clin Invest"},{"key":"7_CR114","first-page":"7","volume":"22","author":"JP Kampf","year":"2007","unstructured":"Kampf JP, Kleinfeld AM (2007) Is membrane transport of FFA mediated by lipid, protein, or both? An unknown protein mediates free fatty acid transport across the adipocyte plasma membrane. Physiology (Bethesda) 22:7\u201314","journal-title":"Physiology (Bethesda)"},{"key":"7_CR115","doi-asserted-by":"crossref","first-page":"E1207","DOI":"10.1152\/ajpendo.00259.2007","volume":"293","author":"JP Kampf","year":"2007","unstructured":"Kampf JP, Parmley D, Kleinfeld AM (2007) Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump. Am J Physiol Endocrinol Metab 293:E1207\u2013E1214","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"7_CR116","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cbi.2006.06.007","volume":"163","author":"GE Kass","year":"2006","unstructured":"Kass GE (2006) Mitochondrial involvement in drug-induced hepatic injury. Chem Biol Interact 163:145\u2013159","journal-title":"Chem Biol Interact"},{"key":"7_CR117","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cld.2007.11.005","volume":"12","author":"GE Kass","year":"2008","unstructured":"Kass GE, Price SC (2008) Role of mitochondria in drug-induced cholestatic injury. Clin Liver Dis 12:27\u201351, vii","journal-title":"Clin Liver Dis"},{"key":"7_CR118","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","volume":"21","author":"C Koliaki","year":"2015","unstructured":"Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M (2015) Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21:739\u2013746","journal-title":"Cell Metab"},{"key":"7_CR119","first-page":"1","volume":"60","author":"S Krahenbuhl","year":"1993","unstructured":"Krahenbuhl S (1993) Alterations in mitochondrial function and morphology in chronic liver disease: pathogenesis and potential for therapeutic intervention. PharmacolTher 60:1\u201338","journal-title":"PharmacolTher"},{"key":"7_CR120","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/hep.1840140528","volume":"14","author":"S Krahenbuhl","year":"1991","unstructured":"Krahenbuhl S, Brass EP (1991) Fuel homeostasis and carnitine metabolism in rats with secondary biliary cirrhosis. Hepatology 14:927\u2013934","journal-title":"Hepatology"},{"key":"7_CR121","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/hep.1840150631","volume":"15","author":"S Kr\u00e4henb\u00fchl","year":"1992","unstructured":"Kr\u00e4henb\u00fchl S, Kr\u00e4henb\u00fchl-Glauser S, Stucki J, Gehr P, Reichen J (1992a) Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte. Hepatology 15:1167\u20131172","journal-title":"Hepatology"},{"key":"7_CR122","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/hep.1840150630","volume":"15","author":"S Kr\u00e4henb\u00fchl","year":"1992","unstructured":"Kr\u00e4henb\u00fchl S, Stucki J, Reichen J (1992b) Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis. Hepatology 15:1160\u20131166","journal-title":"Hepatology"},{"key":"7_CR123","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/hep.1840200632","volume":"20","author":"S Kr\u00e4henb\u00fchl","year":"1994","unstructured":"Kr\u00e4henb\u00fchl S, Fischer S, Talos C, Reichen PJ (1994) Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: dose-response study in isolated rat liver mitochondria. Hepatology 20:1595\u20131601","journal-title":"Hepatology"},{"key":"7_CR124","first-page":"607","volume":"22","author":"S Kr\u00e4henb\u00fchl","year":"1995","unstructured":"Kr\u00e4henb\u00fchl S, Talos C, Lauterburg BH, Reichen J (1995) Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22:607\u2013612","journal-title":"Hepatology"},{"key":"7_CR125","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0168-8278(00)80362-1","volume":"33","author":"L Kr\u00e4henb\u00fchl","year":"2000","unstructured":"Kr\u00e4henb\u00fchl L, Ledermann M, Lang C, Kr\u00e4henb\u00fchl S (2000) Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis. J Hepatol 33:216\u2013223","journal-title":"J Hepatol"},{"key":"7_CR126","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.bpg.2010.08.005","volume":"24","author":"M Krawczyk","year":"2010","unstructured":"Krawczyk M, Bonfrate L, Portincasa P (2010) Nonalcoholic fatty liver disease. Best Pract Res Clin Gastroenterol 24:695\u2013708","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"7_CR127","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-0033-1358525","volume":"33","author":"M Krawczyk","year":"2013","unstructured":"Krawczyk M, Portincasa P, Lammert F (2013) PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease. Semin Liver Dis 33:369\u2013379","journal-title":"Semin Liver Dis"},{"key":"7_CR128","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.taap.2005.03.016","volume":"209","author":"G Krumschnabel","year":"2005","unstructured":"Krumschnabel G, Manzl C, Berger C, Hofer B (2005) Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicol Appl Pharmacol 209:62\u201373","journal-title":"Toxicol Appl Pharmacol"},{"key":"7_CR129","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","volume":"146","author":"JE Lambert","year":"2014","unstructured":"Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ (2014) Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 146:726\u2013735","journal-title":"Gastroenterology"},{"key":"7_CR130","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0168-8278(88)80012-6","volume":"7","author":"BH Lauterburg","year":"1988","unstructured":"Lauterburg BH, Bilzer M (1988) Mechanisms of acetaldehyde hepatotoxicity. J Hepatol 7:384\u2013390","journal-title":"J Hepatol"},{"key":"7_CR131","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-3565(25)21438-0","volume":"230","author":"BH Lauterburg","year":"1984","unstructured":"Lauterburg BH, Davies S, Mitchell J (1984) Ethanol suppresses hepatic glutathione synthesis in rats in vivo. J Pharmacol Exp Ther 230:7\u201311","journal-title":"J Pharmacol Exp Ther"},{"key":"7_CR132","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/hep.1840170311","volume":"17","author":"BH Lauterburg","year":"1993","unstructured":"Lauterburg BH, Liang D, Schwarzenbach FA, Breen KJ (1993) Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology 17:418\u2013422","journal-title":"Hepatology"},{"key":"7_CR133","first-page":"378","volume":"125","author":"BH Lauterburg","year":"1995","unstructured":"Lauterburg BH, Grattagliano I, Gm\u00fcR R, Stalder M, Hildebrand P (1995) Noninvasive assessment of the effect of xenobiotics on mitochondrial function in human beings: studies with acetylsalicylic acid and ethanol with the use of the carbon 13-labeled ketoisocaproate breath test. J Lab Clin Med 125:378\u2013383","journal-title":"J Lab Clin Med"},{"key":"7_CR134","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.pathol.4.110807.092205","volume":"4","author":"PL Lee","year":"2009","unstructured":"Lee PL, Beutler E (2009) Regulation of hepcidin and iron-overload disease. Annu Rev Pathol Mech Dis 4:489\u2013515","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"7_CR135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2012.02.028","volume":"57","author":"A Leroux","year":"2012","unstructured":"Leroux A, Ferrere G, Godie V, Cailleux F, Renoud M-L, Gaudin F, Naveau S, Pr\u00e9vot S, Makhzami S, Perlemuter G (2012) Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J Hepatol 57:141\u2013149","journal-title":"J Hepatol"},{"key":"7_CR136","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbagen.2008.09.008","volume":"1790","author":"S Levi","year":"2009","unstructured":"Levi S, Rovida E (2009) The role of iron in mitochondrial function. Biochim Biophys Acta 1790:629\u2013636","journal-title":"Biochim Biophys Acta"},{"key":"7_CR137","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1096\/fj.06-7345com","volume":"21","author":"Y Li","year":"2007","unstructured":"Li Y, Boehning DF, Qian T, Popov VL, Weinman SA (2007) Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity. FASEB J 21:2474\u20132485","journal-title":"FASEB J"},{"key":"7_CR138","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1172\/JCI114068","volume":"83","author":"C Lieber","year":"1989","unstructured":"Lieber C, Baraona E, Hernandez-Munoz R, Kubota S, Sato N, Kawano S, Matsumura T, Inatomi N (1989) Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates. J Clin Investig 83:1682","journal-title":"J Clin Investig"},{"key":"7_CR139","doi-asserted-by":"crossref","first-page":"14890","DOI":"10.1074\/jbc.M010286200","volume":"276","author":"LL Listenberger","year":"2001","unstructured":"Listenberger LL, Ory DS, Schaffer JE (2001) Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276:14890\u201314895","journal-title":"J Biol Chem"},{"key":"7_CR140","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.freeradbiomed.2012.02.008","volume":"52","author":"C Loguercio","year":"2012","unstructured":"Loguercio C, Andreone P, Brisc C, Brisc MC, Bugianesi E, Chiaramonte M, Cursaro C, Danila M, de Sio I, Floreani A, Freni MA, Grieco A, Groppo M, Lazzari R, Lobello S, Lorefice E, Margotti M, Miele L, Milani S, Okolicsanyi L, Palasciano G, Portincasa P, Saltarelli P, Smedile A, Somalvico F, Spadaro A, Sporea I, Sorrentino P, Vecchione R, Tuccillo C, del Vecchio Blanco C, Federico A (2012) Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 52:1658\u20131665","journal-title":"Free Radic Biol Med"},{"key":"7_CR141","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","volume":"10","author":"R Loomba","year":"2013","unstructured":"Loomba R, Sanyal AJ (2013) The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol 10:686\u2013690","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"7_CR142","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","volume":"55","author":"J Ludwig","year":"1980","unstructured":"Ludwig J, Viggiano TR, McGill DB, Oh BJ (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55:434\u2013438","journal-title":"Mayo Clin Proc"},{"key":"7_CR143","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00232-017-9947-0","volume":"250","author":"L Ma","year":"2017","unstructured":"Ma L, Dong JX, Wu C, Li XY, Chen J, Zhang H, Liu Y (2017) Spectroscopic, polarographic, and microcalorimetric studies on mitochondrial dysfunction induced by ethanol. J Membr Biol 250:195\u2013204","journal-title":"J Membr Biol"},{"key":"7_CR144","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1136\/gutjnl-2014-307362","volume":"64","author":"MV Machado","year":"2015","unstructured":"Machado MV, Michelotti GA, Pereira Tde A, Boursier J, Kruger L, Swiderska-Syn M, Karaca G, Xie G, Guy CD, Bohinc B, Lindblom KR, Johnson E, Kornbluth S, Diehl AM (2015) Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. Gut 64:1148\u20131157","journal-title":"Gut"},{"key":"7_CR145","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","volume":"134","author":"H Malhi","year":"2008","unstructured":"Malhi H, Gores GJ (2008a) Cellular and molecular mechanisms of liver injury. Gastroenterology 134:1641\u20131654","journal-title":"Gastroenterology"},{"key":"7_CR146","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-0028-1091980","volume":"28","author":"H Malhi","year":"2008","unstructured":"Malhi H, Gores GJ (2008b) Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 28:360\u2013369","journal-title":"Semin Liver Dis"},{"key":"7_CR147","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/gast.1997.v113.pm9247482","volume":"113","author":"A Mansouri","year":"1997","unstructured":"Mansouri A, Gaou I, Fromenty B, Berson A, Letteron P, Degott C, Erlinger S, Pessayre D (1997) Premature oxidative aging of hepatic mitochondrial DNA in Wilson\u2019s disease. Gastroenterology 113:599\u2013605","journal-title":"Gastroenterology"},{"key":"7_CR148","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.3748\/wjg.v13.i37.4967","volume":"13","author":"SK Mantena","year":"2007","unstructured":"Mantena SK, King AL, Andringa KK, Landar A, Darley-Usmar V, Bailey SM (2007) Novel interactions of mitochondria and reactive oxygen\/nitrogen species in alcohol mediated liver disease. World J Gastroenterol 13:4967","journal-title":"World J Gastroenterol"},{"key":"7_CR149","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.freeradbiomed.2007.12.029","volume":"44","author":"SK Mantena","year":"2008","unstructured":"Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM (2008) Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med 44:1259\u20131272","journal-title":"Free Radic Biol Med"},{"key":"7_CR150","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/JVI.71.2.1301-1309.1997","volume":"71","author":"M Matsumoto","year":"1997","unstructured":"Matsumoto M, Hsieh T-Y, Zhu N, Vanarsdale T, Hwang SB, Jeng K-S, Gorbalenya AE, Lo S-Y, Ou J-H, Ware CF (1997) Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol 71:1301\u20131309","journal-title":"J Virol"},{"key":"7_CR151","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","volume":"116","author":"CA Matteoni","year":"1999","unstructured":"Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ (1999) Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116:1413\u20131419","journal-title":"Gastroenterology"},{"key":"7_CR152","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cmet.2015.07.028","volume":"22","author":"KS Mccommis","year":"2015","unstructured":"Mccommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN (2015) Loss of mitochondrial pyruvate carrier 2 in the liver leads to defects in gluconeogenesis and compensation via pyruvate-alanine cycling. Cell Metab 22:682\u2013694","journal-title":"Cell Metab"},{"issue":"5","key":"7_CR153","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/hep.29025","volume":"65","author":"K Mccommis","year":"2016","unstructured":"Mccommis K, Hodges W, Brunt E, Nalbantoglu I, McDonald W, Holley C, Fujiwara H, Schaffer J, Colca J, Finck B (2016) Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology (Baltimore, Md) 65(5):1543\u20131556","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"Suppl 1","key":"7_CR154","first-page":"S17","volume":"40","author":"AJ McCullough","year":"2006","unstructured":"McCullough AJ (2006) Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 40(Suppl 1):S17\u2013S29","journal-title":"J Clin Gastroenterol"},{"key":"7_CR155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbi.2006.05.011","volume":"163","author":"R Mehta","year":"2006","unstructured":"Mehta R, Templeton DM, O\u2019Brien PJ (2006) Mitochondrial involvement in genetically determined transition metal toxicity: II. Copper toxicity. Chem Biol Interact 163:77\u201385","journal-title":"Chem Biol Interact"},{"key":"7_CR156","first-page":"S30","volume":"40","author":"RB Merriman","year":"2006","unstructured":"Merriman RB, Aouizerat BE, Bass NM (2006) Genetic influences in nonalcoholic fatty liver disease. J Clin Gastroenterol 40:S30\u2013S33","journal-title":"J Clin Gastroenterol"},{"key":"7_CR157","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.1840100513","volume":"10","author":"PA Michaletz","year":"1989","unstructured":"Michaletz PA, Cap L, Alpert E, Lauterburg BH (1989) Assessment of mitochondrial function in vivo with a breath test utilizing \u03b1-ketoisocaproic acid. Hepatology 10:829\u2013832","journal-title":"Hepatology"},{"key":"7_CR158","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1111\/j.1572-0241.2003.07725.x","volume":"98","author":"L Miele","year":"2003","unstructured":"Miele L, Grieco A, Armuzzi A, Candelli M, Forgione A, Gasbarrini A, Gasbarrini G (2003) Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test. Am J Gastroenterol 98:2335\u20132336","journal-title":"Am J Gastroenterol"},{"key":"7_CR159","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","volume":"49","author":"L Miele","year":"2009","unstructured":"Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, Masciana R, Forgione A, Gabrieli ML, Perotti G, Vecchio FM, Rapaccini G, Gasbarrini G, Day CP, Grieco A (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49:1877\u20131887","journal-title":"Hepatology"},{"key":"7_CR160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1023\/A:1018824004318","volume":"43","author":"C Miki","year":"1998","unstructured":"Miki C, Iriyama K, Mirza DF, Mayer AD, Buckels JA, Suzuki H, McMaster P (1998) Postperfusion energy metabolism of steatotic graft and its relation to early graft viability following liver transplantation. Dig Dis Sci 43:74\u201379","journal-title":"Dig Dis Sci"},{"key":"7_CR161","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0168-8278(00)80196-8","volume":"32","author":"T Minor","year":"2000","unstructured":"Minor T, Akbar S, Tolba R, Dombrowski F (2000) Cold preservation of fatty liver grafts: prevention of functional and ultrastructural impairments by venous oxygen persufflation. J Hepatol 32:105\u2013111","journal-title":"J Hepatol"},{"key":"7_CR162","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1101\/gr.5755407","volume":"17","author":"O Mirabeau","year":"2007","unstructured":"Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R, Birney E, Rosenthal N, Gross C (2007) Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Genome Res 17:320\u2013327","journal-title":"Genome Res"},{"key":"7_CR163","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1872-034X.2008.00464.x","volume":"39","author":"H Mitsuyoshi","year":"2009","unstructured":"Mitsuyoshi H, Yasui K, Harano Y, Endo M, Tsuji K, Minami M, Itoh Y, Okanoue T, Yoshikawa T (2009) Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res 39:366\u2013373","journal-title":"Hepatol Res"},{"key":"7_CR164","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/hep.24731","volume":"55","author":"JW Molloy","year":"2012","unstructured":"Molloy JW, Calcagno CJ, Williams CD, Jones FJ, Torres DM, Harrison SA (2012) Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. Hepatology 55:429\u2013436","journal-title":"Hepatology"},{"key":"7_CR165","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jhep.2011.10.008","volume":"56","author":"J Monsenego","year":"2012","unstructured":"Monsenego J, Mansouri A, Akkaoui M, Lenoir V, Esnous C, Fauveau V, Tavernier V, Girard J, Prip-Buus C (2012) Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis. J Hepatol 56:632\u2013639","journal-title":"J Hepatol"},{"key":"7_CR166","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1016\/S0021-9258(18)45199-X","volume":"262","author":"RI Montgomery","year":"1987","unstructured":"Montgomery RI, Coleman WB, Eble KS, Cunningham CC (1987) Ethanol-elicited alterations in the oligomycin sensitivity and structural stability of the mitochondrial F0. F1 ATPase. J Biol Chem 262:13285\u201313289","journal-title":"J Biol Chem"},{"key":"7_CR167","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.physiol.70.113006.100707","volume":"70","author":"MG Myers","year":"2008","unstructured":"Myers MG, Cowley MA, Munzberg H (2008) Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70:537\u2013556","journal-title":"Annu Rev Physiol"},{"key":"7_CR168","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0041-1345(99)00873-8","volume":"32","author":"B Nardo","year":"2000","unstructured":"Nardo B, Grattagliano I, Domenicali M, Caraceni P, Catena F, Santoni B, Turi P, Cavallari G, Dall\u2019agata M, Trevisani F (2000) Mitochondrial oxidative injury in rat fatty livers exposed to warm ischemia-reperfusion. Transplant Proc 32:51","journal-title":"Transplant Proc"},{"key":"7_CR169","doi-asserted-by":"crossref","first-page":"19180","DOI":"10.1074\/jbc.271.32.19180","volume":"271","author":"D Nikitovic","year":"1996","unstructured":"Nikitovic D, Holmgren A (1996) S-Nitrosoglutathione is cleaved by the thioredoxin system with liberation of glutathione and redox regulating nitric oxide. J Biol Chem 271:19180\u201319185","journal-title":"J Biol Chem"},{"key":"7_CR170","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.1079368","volume":"299","author":"E Nisoli","year":"2003","unstructured":"Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S (2003) Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299:896\u2013899","journal-title":"Science"},{"key":"7_CR171","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1099\/vir.0.81701-0","volume":"87","author":"Y Nomura-Takigawa","year":"2006","unstructured":"Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H (2006) Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J Gen Virol 87:1935\u20131945","journal-title":"J Gen Virol"},{"key":"7_CR172","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/hep.26465","volume":"58","author":"M Noureddin","year":"2013","unstructured":"Noureddin M, Yates KP, Vaughn IA, Neuschwander-Tetri BA, Sanyal AJ, McCullough A, Merriman R, Hameed B, Doo E, Kleiner DE, Behling C, Loomba R, Nash CRN (2013) Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients. Hepatology 58:1644\u20131654","journal-title":"Hepatology"},{"key":"7_CR173","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/gast.2002.30983","volume":"122","author":"M Okuda","year":"2002","unstructured":"Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, Weinman SA (2002) Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122:366\u2013375","journal-title":"Gastroenterology"},{"key":"7_CR174","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(01)00647-5","volume":"31","author":"LH Ottesen","year":"2001","unstructured":"Ottesen LH, Harry D, Frost M, Davies S, Khan K, Halliwell B, Moore K (2001) Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia. Free Radic Biol Med 31:790\u2013798","journal-title":"Free Radic Biol Med"},{"key":"7_CR175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00441-004-0872-z","volume":"316","author":"L Papucci","year":"2004","unstructured":"Papucci L, Formigli L, Schiavone N, Tani A, Donnini M, Lapucci A, Perna F, Tempestini A, Witort E, Morganti M (2004) Apoptosis shifts to necrosis via intermediate types of cell death by a mechanism depending on c-myc and bcl-2 expression. Cell Tissue Res 316:197\u2013209","journal-title":"Cell Tissue Res"},{"key":"7_CR176","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-1119(01)00814-9","volume":"286","author":"G Paradies","year":"2002","unstructured":"Paradies G, Petrosillo G, Pistolese M, Ruggiero FM (2002) Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage. Gene 286:135\u2013141","journal-title":"Gene"},{"key":"7_CR177","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.1840380426","volume":"38","author":"M P\u00e9rez-Carreras","year":"2003","unstructured":"P\u00e9rez-Carreras M, Del Hoyo P, Mart\u00edn MA, Rubio JC, Mart\u00edn A, Castellano G, Colina F, Arenas J, Solis-Herruzo JA (2003) Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38:999\u20131007","journal-title":"Hepatology"},{"key":"7_CR178","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cmet.2013.10.004","volume":"18","author":"RJ Perry","year":"2013","unstructured":"Perry RJ, Kim T, Zhang X-M, Lee H-Y, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW (2013) Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metab 18:740\u2013748","journal-title":"Cell Metab"},{"key":"7_CR179","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jhep.2005.03.004","volume":"42","author":"D Pessayre","year":"2005","unstructured":"Pessayre D, Fromenty B (2005) NASH: a mitochondrial disease. J Hepatol 42:928\u2013940","journal-title":"J Hepatol"},{"key":"7_CR180","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0168-8278(99)80360-2","volume":"31","author":"D Pessayre","year":"1999","unstructured":"Pessayre D, Haouzi D, Fau D, Robin MA, Mansouri A, Berson A (1999a) Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: different forms of drug-induced hepatic apoptosis. J Hepatol 31:760\u2013770","journal-title":"J Hepatol"},{"key":"7_CR181","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1023\/A:1007649815992","volume":"15","author":"D Pessayre","year":"1999","unstructured":"Pessayre D, Mansouri A, Haouzi D, Fromenty B (1999b) Hepatotoxicity due to mitochondrial dysfunction. Cell Biol Toxicol 15:367\u2013373","journal-title":"Cell Biol Toxicol"},{"key":"7_CR182","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.ijo.0802868","volume":"29","author":"O Petrescu","year":"2005","unstructured":"Petrescu O, Fan X, Gentileschi P, Hossain S, Bradbury M, Gagner M, Berk PD (2005) Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity. Int J Obes 29:196\u2013203","journal-title":"Int J Obes"},{"key":"7_CR183","first-page":"1260","volume":"1767","author":"G Petrosillo","year":"2007","unstructured":"Petrosillo G, Portincasa P, Grattagliano I, Casanova G, Matera M, Ruggiero FM, Ferri D, Paradies G (2007) Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin. BiochimBiophysActa 1767:1260\u20131267","journal-title":"BiochimBiophysActa"},{"key":"7_CR184","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2036.2011.04929.x","volume":"35","author":"S Petta","year":"2012","unstructured":"Petta S, Amato MC, Di Marco V, Camma C, Pizzolanti G, Barcellona MR, Cabibi D, Galluzzo A, Sinagra D, Giordano C, Craxi A (2012) Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 35:238\u2013247","journal-title":"Aliment Pharmacol Ther"},{"key":"7_CR185","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/hep.21679","volume":"46","author":"C Piccoli","year":"2007","unstructured":"Piccoli C, Scrima R, Quarato G, D\u2019Aprile A, Ripoli M, Lecce L, Boffoli D, Moradpour D, Capitanio N (2007) Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress. Hepatology 46:58\u201365","journal-title":"Hepatology"},{"key":"7_CR186","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-2952(90)90655-5","volume":"39","author":"A Pietrangelo","year":"1990","unstructured":"Pietrangelo A, Grandi R, Tripodi A, Tomasi A, Ceccarelli D, Ventura E, Masini A (1990) Lipid composition and fluidity of liver mitochondria, microsomes and plasma membrane of rats with chronic dietary iron overload. Biochem Pharmacol 39:123\u2013128","journal-title":"Biochem Pharmacol"},{"key":"7_CR187","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/s-0035-1562949","volume":"35","author":"C Pocha","year":"2015","unstructured":"Pocha C, Kolly P, Dufour JF (2015) Nonalcoholic fatty liver disease-related hepatocellular carcinoma: a problem of growing magnitude. Semin Liver Dis 35:304\u2013317","journal-title":"Semin Liver Dis"},{"key":"7_CR188","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1194\/jlr.M100404-JLR200","volume":"43","author":"J Pohl","year":"2002","unstructured":"Pohl J, Ring A, Stremmel W (2002) Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res 43:1390\u20131399","journal-title":"J Lipid Res"},{"key":"7_CR189","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/jhep.2000.17894","volume":"32","author":"A Poonawala","year":"2000","unstructured":"Poonawala A, Nair SP, Thuluvath PJ (2000) Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 32:689\u2013692","journal-title":"Hepatology"},{"key":"7_CR190","volume-title":"Gallstones. Recent advances in epidemiology, pathogenesis, diagnosis and management","author":"P Portincasa","year":"2017","unstructured":"Portincasa P, Wang DQH (2017) Nonalcoholic fatty liver and gallstone disease. In: Wang DQH, Portincasa P (eds) Gallstones. Recent advances in epidemiology, pathogenesis, diagnosis and management. Nova Science Publishers, Inc, New York"},{"key":"7_CR191","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/CS20050346","volume":"111","author":"P Portincasa","year":"2006","unstructured":"Portincasa P, Grattagliano I, Lauterburg BH, Palmieri VO, Palasciano G, Stellaard F (2006) Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis. Clin Sci (Lond) 111:135\u2013143","journal-title":"Clin Sci (Lond)"},{"key":"7_CR192","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.freeradbiomed.2007.01.039","volume":"42","author":"P Portincasa","year":"2007","unstructured":"Portincasa P, Grattagliano I, Testini M, Caruso ML, Wang DQ, Moschetta A, Calamita G, Vacca M, Valentini AM, Renna G, Lissidini G, Palasciano G (2007) Parallel intestinal and liver injury during early cholestasis in the rat: modulation by bile salts and antioxidants. Free RadicBiolMed 42:1381\u20131391","journal-title":"Free RadicBiolMed"},{"key":"7_CR193","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","volume":"118","author":"C Postic","year":"2008","unstructured":"Postic C, Girard J (2008) Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118:829\u2013838","journal-title":"J Clin Invest"},{"key":"7_CR194","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/jn\/134.5.1003","volume":"134","author":"JR Prohaska","year":"2004","unstructured":"Prohaska JR, Gybina AA (2004) Intracellular copper transport in mammals. J Nutr 134:1003\u20131006","journal-title":"J Nutr"},{"key":"7_CR195","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1530-0277.1989.tb00326.x","volume":"13","author":"ME Quintanilla","year":"1989","unstructured":"Quintanilla ME, Tampier L (1989) Sensitivity of liver mitochondrial functions to various levels of ethanol intake in the rat. Alcohol Clin Exp Res 13:280\u2013283","journal-title":"Alcohol Clin Exp Res"},{"key":"7_CR196","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0016-5085(00)70364-7","volume":"118","author":"V Ratziu","year":"2000","unstructured":"Ratziu V, Giral P, Charlotte F, Bruckert E, Thibault V, Theodorou I, Khalil L, Turpin G, Opolon P, Poynard T (2000) Liver fibrosis in overweight patients. Gastroenterology 118:1117\u20131123","journal-title":"Gastroenterology"},{"key":"7_CR197","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1124\/jpet.108.143578","volume":"327","author":"H Rehman","year":"2008","unstructured":"Rehman H, Ramshesh VK, Theruvath TP, Kim I, Currin RT, Giri S, Lemasters JJ, Zhong Z (2008) NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J Pharmacol Exp Ther 327:699\u2013706","journal-title":"J Pharmacol Exp Ther"},{"key":"7_CR198","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/0006-2952(94)90312-3","volume":"47","author":"C Ribiere","year":"1994","unstructured":"Ribiere C, Hininger I, Saffar-Boccara C, Sabourault D, Nordmann R (1994) Mitochondrial respiratory activity and superoxide radical generation in the liver, brain and heart after chronic ethanol intake. Biochem Pharmacol 47:1827\u20131833","journal-title":"Biochem Pharmacol"},{"key":"7_CR199","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/adc.58.11.916","volume":"58","author":"C Roe","year":"1983","unstructured":"Roe C, Hoppel CL, Stacey T, Chalmers R, Tracey B, Millington D (1983) Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups. Arch Dis Child 58:916\u2013920","journal-title":"Arch Dis Child"},{"key":"7_CR200","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/jgh.12019","volume":"28","author":"YS Roh","year":"2013","unstructured":"Roh YS, Seki E (2013) Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol 28:38\u201342","journal-title":"J Gastroenterol Hepatol"},{"key":"7_CR201","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/toxsci\/57.1.177","volume":"57","author":"AP Rolo","year":"2000","unstructured":"Rolo AP, Oliveira PJ, Moreno AJ, Palmeira CM (2000) Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. Toxicol Sci 57:177\u2013185","journal-title":"Toxicol Sci"},{"key":"7_CR202","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2310\/6650.2002.33433","volume":"50","author":"AP Rolo","year":"2002","unstructured":"Rolo AP, Oliveira PJ, Sei\u00e7A R, Santos MS, Moreno AJ, Palmeira CM (2002a) Disruption of mitochondrial calcium homeostasis after chronic \u03b1-naphthylisothiocyanate administration: relevance for cholestasis. J Investig Med 50:193\u2013200","journal-title":"J Investig Med"},{"key":"7_CR203","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/taap.2002.9434","volume":"182","author":"AP Rolo","year":"2002","unstructured":"Rolo AP, Oliveira PJ, Sei\u00e7a R, Santos MS, Moreno AJ, Palmeira CM (2002b) Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of \u03b1-naphthylisothiocyanate. Toxicol Appl Pharmacol 182:20\u201326","journal-title":"Toxicol Appl Pharmacol"},{"key":"7_CR204","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cbi.2009.08.014","volume":"182","author":"DN Roy","year":"2009","unstructured":"Roy DN, Mandal S, Sen G, Biswas T (2009) Superoxide anion mediated mitochondrial dysfunction leads to hepatocyte apoptosis preferentially in the periportal region during copper toxicity in rats. Chem Biol Interact 182:136\u2013147","journal-title":"Chem Biol Interact"},{"key":"7_CR205","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI30400","volume":"117","author":"VT Samuel","year":"2007","unstructured":"Samuel VT, Liu Z-X, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang X-M, Monia BP, Bhanot S, Shulman GI (2007) Inhibition of protein kinase C\u03b5 prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J Clin Invest 117:739\u2013745","journal-title":"J Clin Invest"},{"key":"7_CR206","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","volume":"120","author":"AJ Sanyal","year":"2001","unstructured":"Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN (2001) Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120:1183\u20131192","journal-title":"Gastroenterology"},{"key":"7_CR207","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00041433-200306000-00008","volume":"14","author":"JE Schaffer","year":"2003","unstructured":"Schaffer JE (2003) Lipotoxicity: when tissues overeat. Curr Opin Lipidol 14:281\u2013287","journal-title":"Curr Opin Lipidol"},{"key":"7_CR208","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0092-8674(94)90252-6","volume":"79","author":"JE Schaffer","year":"1994","unstructured":"Schaffer JE, Lodish HF (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79:427\u2013436","journal-title":"Cell"},{"key":"7_CR209","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0005-2736(80)90373-9","volume":"603","author":"RJ Schilling","year":"1980","unstructured":"Schilling RJ, Reitz RC (1980) A mechanism for ethanol-induced damage to liver mitochondrial structure and function. Biochim Biophys Acta 603:266\u2013277","journal-title":"Biochim Biophys Acta"},{"key":"7_CR210","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1053\/j.gastro.2014.01.020","volume":"146","author":"B Schnabl","year":"2014","unstructured":"Schnabl B, Brenner DA (2014) Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146:1513\u20131524","journal-title":"Gastroenterology"},{"key":"7_CR211","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","volume":"13","author":"E Seki","year":"2007","unstructured":"Seki E, De Minicis S, \u00d6sterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF (2007) TLR4 enhances TGF-\u03b2 signaling and hepatic fibrosis. Nat Med 13:1324\u20131332","journal-title":"Nat Med"},{"key":"7_CR212","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ana.20047","volume":"55","author":"CT Sheline","year":"2004","unstructured":"Sheline CT, Choi DW (2004) Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo. Ann Neurol 55:645\u2013653","journal-title":"Ann Neurol"},{"key":"7_CR213","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/43448","volume":"401","author":"I Shimomura","year":"1999","unstructured":"Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401:73\u201376","journal-title":"Nature"},{"key":"7_CR214","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJMra1011035","volume":"371","author":"GI Shulman","year":"2014","unstructured":"Shulman GI (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371:1131\u20131141","journal-title":"N Engl J Med"},{"key":"7_CR215","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cgh.2014.04.014","volume":"13","author":"S Singh","year":"2015","unstructured":"Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R (2015) Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol 13:643\u201354 e1\u20139; quiz e39\u201340","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7_CR216","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1074\/jbc.M008363200","volume":"276","author":"EA Slee","year":"2001","unstructured":"Slee EA, Adrain C, Martin SJ (2001) Executioner caspase-3,-6, and-7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276:7320\u20137326","journal-title":"J Biol Chem"},{"key":"7_CR217","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0016-5085(90)90627-D","volume":"99","author":"RJ Sokol","year":"1990","unstructured":"Sokol RJ, Deverbaux M, Mierau GW, Hambidge KM, Shikes RH (1990) Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload: modification by vitamin E deficiency. Gastroenterology 99:1061\u20131071","journal-title":"Gastroenterology"},{"key":"7_CR218","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0022-2275(20)41965-0","volume":"32","author":"RJ Sokol","year":"1991","unstructured":"Sokol RJ, Devereaux M, Khandwala RA (1991) Effect of dietary lipid and vitamin E on mitochondrial lipid peroxidation and hepatic injury in the bile duct-ligated rat. J Lipid Res 32:1349\u20131357","journal-title":"J Lipid Res"},{"key":"7_CR219","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1042\/bj2020445","volume":"202","author":"PI Spach","year":"1982","unstructured":"Spach PI, Bottenus RE, Cunningham CC (1982) Control of adenine nucleotide metabolism in hepatic mitochondria from rats with ethanol-induced fatty liver. Biochem J 202:445\u2013452","journal-title":"Biochem J"},{"key":"7_CR220","doi-asserted-by":"crossref","first-page":"e1001324","DOI":"10.1371\/journal.pgen.1001324","volume":"7","author":"EK Speliotes","year":"2011","unstructured":"Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O\u2019Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS, Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB (2011) Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 7:e1001324","journal-title":"PLoS Genet"},{"key":"7_CR221","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1043-2760(01)00427-1","volume":"12","author":"A Stahl","year":"2001","unstructured":"Stahl A, Gimeno RE, Tartaglia LA, Lodish HF (2001) Fatty acid transport proteins: a current view of a growing family. Trends Endocrinol Metab 12:266\u2013273","journal-title":"Trends Endocrinol Metab"},{"key":"7_CR222","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/hep.1840160319","volume":"16","author":"I Sternlieb","year":"1992","unstructured":"Sternlieb I (1992) Fraternal concordance of types of abnormal hepatocellular mitochondria in Wilson\u2019s disease. Hepatology 16:728\u2013732","journal-title":"Hepatology"},{"key":"7_CR223","doi-asserted-by":"crossref","first-page":"15815","DOI":"10.1021\/ja0529135","volume":"127","author":"DA Stoyanovsky","year":"2005","unstructured":"Stoyanovsky DA, Tyurina YY, Tyurin VA, Anand D, Mandavia DN, Gius D, Ivanova J, Pitt B, Billiar TR, Kagan VE (2005) Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. J Am Chem Soc 127:15815\u201315823","journal-title":"J Am Chem Soc"},{"key":"7_CR224","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1073\/pnas.82.1.4","volume":"82","author":"W Stremmel","year":"1985","unstructured":"Stremmel W, Strohmeyer G, Borchard F, Kochwa S, Berk PD (1985) Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. Proc Natl Acad Sci U S A 82:4\u20138","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7_CR225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/ajcp\/73.1.12","volume":"73","author":"FW Stromeyer","year":"1980","unstructured":"Stromeyer FW, Ishak KG (1980) Histology of the liver in Wilson\u2019s disease: a study of 34 cases. Am J Clin Pathol 73:12\u201324","journal-title":"Am J Clin Pathol"},{"key":"7_CR226","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1016\/j.bbagen.2016.09.009","volume":"1861","author":"Q Sun","year":"2017","unstructured":"Sun Q, Zhang W, Zhong W, Sun X, Zhou Z (2017) Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function. Biochim Biophys Acta 1861:2912\u20132921","journal-title":"Biochim Biophys Acta"},{"key":"7_CR227","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0005-2728(98)00110-8","volume":"1366","author":"SA Susin","year":"1998","unstructured":"Susin SA, Zamzami N, Kroemer G (1998) Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1366:151\u2013165","journal-title":"Biochim Biophys Acta"},{"key":"7_CR228","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1530-0277.2008.00803.x","volume":"33","author":"P Sykora","year":"2009","unstructured":"Sykora P, Kharbanda KK, Crumm SE, Cahill A (2009) S-Adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats. Alcohol Clin Exp Res 33:1\u20139","journal-title":"Alcohol Clin Exp Res"},{"key":"7_CR229","first-page":"385","volume":"132","author":"WS Thayer","year":"1980","unstructured":"Thayer WS, Rubin E (1980) Effects of chronic ethanol consumption on the respiratory chain of rat liver submitochondrial particles. Adv Exp Med Biol 132:385\u2013392","journal-title":"Adv Exp Med Biol"},{"key":"7_CR230","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s10495-009-0357-3","volume":"14","author":"M-M Tiao","year":"2009","unstructured":"Tiao M-M, Lin T-K, Liou C-W, Wang P-W, Chen J-B, Kuo F-Y, Huang C-C, Chou Y-M, Chuang J-H (2009) Early transcriptional deregulation of hepatic mitochondrial biogenesis and its consequent effects on murine cholestatic liver injury. Apoptosis 14:890\u2013899","journal-title":"Apoptosis"},{"key":"7_CR231","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.26604","volume":"59","author":"K Tomita","year":"2014","unstructured":"Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Okada Y, Kurihara C, Irie R, Yokoyama H, Shimamura K, Usui S, Ebinuma H, Saito H, Watanabe C, Komoto S, Kawaguchi A, Nagao S, Sugiyama K, Hokari R, Kanai T, Miura S, Hibi T (2014) Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology 59:154\u2013169","journal-title":"Hepatology"},{"key":"7_CR232","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-0032-1306424","volume":"32","author":"DM Torres","year":"2012","unstructured":"Torres DM, Harrison SA (2012) Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soil. Semin Liver Dis 32:30\u201338","journal-title":"Semin Liver Dis"},{"key":"7_CR233","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0168-8278(96)80195-4","volume":"24","author":"F Trevisani","year":"1996","unstructured":"Trevisani F, Colantoni A, Caraceni P, Van Thiel DH (1996) The use of donor fatty liver for liver transplantation: a challenge or a quagmire? J Hepatol 24:114\u2013121","journal-title":"J Hepatol"},{"key":"7_CR234","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/bbrc.1998.0123","volume":"255","author":"BL Trigatti","year":"1999","unstructured":"Trigatti BL, Anderson RG, Gerber GE (1999) Identification of caveolin-1 as a fatty acid binding protein. Biochem Biophys Res Commun 255:34\u201339","journal-title":"Biochem Biophys Res Commun"},{"key":"7_CR235","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.1840120325","volume":"12","author":"H Tsukamoto","year":"1990","unstructured":"Tsukamoto H, Gaal K, French SW (1990) Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12:599\u2013608","journal-title":"Hepatology"},{"key":"7_CR236","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/hep.22998","volume":"50","author":"T Tsutsumi","year":"2009","unstructured":"Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T (2009) Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology 50:378\u2013386","journal-title":"Hepatology"},{"key":"7_CR237","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1210\/en.2003-0870","volume":"144","author":"RH Unger","year":"2003","unstructured":"Unger RH (2003) Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144:5159\u20135165","journal-title":"Endocrinology"},{"key":"7_CR238","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1096\/fj.00-0590","volume":"15","author":"RH Unger","year":"2001","unstructured":"Unger RH, Orci L (2001) Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 15:312\u2013321","journal-title":"FASEB J"},{"key":"7_CR239","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1128\/MCB.00013-08","volume":"28","author":"J-P Upton","year":"2008","unstructured":"Upton J-P, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA (2008) Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 28:3943\u20133951","journal-title":"Mol Cell Biol"},{"key":"7_CR240","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0035-1562944","volume":"35","author":"E Vanni","year":"2015","unstructured":"Vanni E, Marengo A, Mezzabotta L, Bugianesi E (2015) Systemic complications of nonalcoholic fatty liver disease: when the liver is not an innocent bystander. Semin Liver Dis 35:236\u2013249","journal-title":"Semin Liver Dis"},{"key":"7_CR241","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v22.i26.6016","volume":"22","author":"G Vecchione","year":"2016","unstructured":"Vecchione G, Grasselli E, Voci A, Baldini F, Grattagliano I, Wang DQ, Portincasa P, Vergani L (2016) Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells. World J Gastroenterol 22:6016\u20136026","journal-title":"World J Gastroenterol"},{"key":"7_CR242","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0168-8278(98)80201-8","volume":"28","author":"G Vendemiale","year":"1998","unstructured":"Vendemiale G, Grattagliano I, Signorile A, Altomare E (1998) Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: effect of tauroursodeoxycholate. J Hepatol 28:46\u201353","journal-title":"J Hepatol"},{"key":"7_CR243","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0168-8278(02)00234-9","volume":"37","author":"G Vendemiale","year":"2002","unstructured":"Vendemiale G, Grattagliano I, Lupo L, Memeo V, Altomare E (2002) Hepatic oxidative alterations in patients with extra-hepatic cholestasis. Effect of surgical drainage. J Hepatol 37:601\u2013605","journal-title":"J Hepatol"},{"key":"7_CR244","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hep.20326","volume":"40","author":"A Venkatraman","year":"2004","unstructured":"Venkatraman A, Shiva S, Wigley A, Ulasova E, Chhieng D, Bailey SM, Darley-Usmar VM (2004) The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice. Hepatology 40:565\u2013573","journal-title":"Hepatology"},{"key":"7_CR245","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/oby.20725","volume":"22","author":"JL Walewski","year":"2014","unstructured":"Walewski JL, Ge F, Lobdell HT, Levin N, Schwartz GJ, Vasselli JR, Pomp A, Dakin G, Berk PD (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring) 22:1643\u20131652","journal-title":"Obesity (Silver Spring)"},{"key":"7_CR246","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-0035-1550060","volume":"35","author":"MC Wallace","year":"2015","unstructured":"Wallace MC, Friedman SL, Mann DA (2015) Emerging and disease-specific mechanisms of hepatic stellate cell activation. Semin Liver Dis 35:107\u2013118","journal-title":"Semin Liver Dis"},{"key":"7_CR247","doi-asserted-by":"crossref","first-page":"e112327","DOI":"10.1371\/journal.pone.0112327","volume":"9","author":"A Wehr","year":"2014","unstructured":"Wehr A, Baeck C, Ulmer F, Gassler N, Hittatiya K, Luedde T, Neumann UP, Trautwein C, Tacke F (2014) Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. PLoS One 9:e112327","journal-title":"PLoS One"},{"key":"7_CR248","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2353\/ajpath.2009.080697","volume":"174","author":"Y Wei","year":"2009","unstructured":"Wei Y, Clark SE, Thyfault JP, Uptergrove GM, Li W, Whaley-Connell AT, Ferrario CM, Sowers JR, Ibdah JA (2009) Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats. Am J Pathol 174:1329\u20131337","journal-title":"Am J Pathol"},{"key":"7_CR249","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1006\/bbrc.1995.2202","volume":"213","author":"P Wieland","year":"1995","unstructured":"Wieland P, Lauterburg BH (1995) Oxidation of mitochondrial proteins and DNA following administration of ethanol. Biochem Biophys Res Commun 213:815\u2013819","journal-title":"Biochem Biophys Res Commun"},{"key":"7_CR250","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1097\/MEG.0000000000000776","volume":"29","author":"K Wijarnpreecha","year":"2017","unstructured":"Wijarnpreecha K, Thongprayoon C, Ungprasert P (2017) Coffee consumption and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 29:e8\u2013e12","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"7_CR251","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/rmv.611","volume":"19","author":"CD Williamson","year":"2009","unstructured":"Williamson CD, Colberg-Poley AM (2009) Access of viral proteins to mitochondria via mitochondria-associated membranes. Rev Med Virol 19:147\u2013164","journal-title":"Rev Med Virol"},{"key":"7_CR252","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/gut.2009.205088","volume":"59","author":"VW Wong","year":"2010","unstructured":"Wong VW, Wong GL, Choi PC, Chan AW, Li MK, Chan HY, Chim AM, Yu J, Sung JJ, Chan HL (2010) Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut 59:969\u2013974","journal-title":"Gut"},{"key":"7_CR253","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","volume":"334","author":"GD Wu","year":"2011","unstructured":"Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334:105\u2013108","journal-title":"Science"},{"key":"7_CR254","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3109\/00365529209000107","volume":"27","author":"T Yamaguchi","year":"1992","unstructured":"Yamaguchi T, Shimahara Y, Takada Y, Ino K, Mori K, Kobayashi N, Yamaoka Y, Ozawa K (1992) Evaluation of ketogenesis in seriously reduced hepatic mitochondrial redox state an analysis of survivors and non-survivors in critically ill hepatectomized patients. Scand J Gastroenterol 27:472\u2013478","journal-title":"Scand J Gastroenterol"},{"key":"7_CR255","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.3748\/wjg.v13.i16.2352","volume":"13","author":"M Yan","year":"2007","unstructured":"Yan M, Zhu P, Liu H-M, Zhang H-T, Liu L (2007) Ethanol induced mitochondria injury and permeability transition pore opening: role of mitochondria in alcoholic liver disease. World J Gastroenterol 13:2352","journal-title":"World J Gastroenterol"},{"key":"7_CR256","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/abbi.2000.1829","volume":"378","author":"S Yang","year":"2000","unstructured":"Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, Diehl AM (2000) Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 378:259\u2013268","journal-title":"Arch Biochem Biophys"},{"key":"7_CR257","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1053\/jhep.2001.22702","volume":"33","author":"B Yerushalmi","year":"2001","unstructured":"Yerushalmi B, Dahl R, Devereaux MW, Gumpricht E, Sokol RJ (2001) Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology 33:616\u2013626","journal-title":"Hepatology"},{"key":"7_CR258","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/alcalc\/agl017","volume":"41","author":"TA Young","year":"2006","unstructured":"Young TA, Bailey SM, Van Horn CG, Cunningham CC (2006) Chronic ethanol consumption decreases mitochondrial and glycolytic production of ATP in liver. Alcohol Alcohol 41:254\u2013260","journal-title":"Alcohol Alcohol"},{"key":"7_CR259","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/smll.200900520","volume":"5","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Yang M, Park JH, Singelyn J, Ma H, Sailor MJ, Ruoslahti E, Ozkan M, Ozkan C (2009) A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles. Small 5:1990\u20131996","journal-title":"Small"},{"key":"7_CR260","doi-asserted-by":"crossref","first-page":"E1425","DOI":"10.3390\/ijms17091425","volume":"17","author":"L Zhang","year":"2016","unstructured":"Zhang L, Deng S, Zhao S, Ai Y, Zhang L, Pan P, Su X, Tan H, Wu D (2016) Intra-peritoneal administration of mitochondrial DNA provokes acute lung injury and systemic inflammation via Toll-like receptor 9. Int J Mol Sci 17:E1425","journal-title":"Int J Mol Sci"},{"key":"7_CR261","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","volume":"134","author":"J Zhou","year":"2008","unstructured":"Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W (2008) Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology 134:556\u2013567","journal-title":"Gastroenterology"},{"key":"7_CR262","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1128\/JVI.72.5.3691-3697.1998","volume":"72","author":"N Zhu","year":"1998","unstructured":"Zhu N, Khoshnan A, Schneider R, Matsumoto M, Dennert G, Ware C, Lai MM (1998) Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol 72:3691\u20133697","journal-title":"J Virol"},{"key":"7_CR263","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/nyas.12347","volume":"1315","author":"H Zischka","year":"2014","unstructured":"Zischka H, Lichtmannegger J (2014) Pathological mitochondrial copper overload in livers of Wilson\u2019s disease patients and related animal models. Ann N Y Acad Sci 1315:6\u201315","journal-title":"Ann N Y Acad Sci"}],"container-title":["Mitochondrial Biology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-73344-9_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:15:07Z","timestamp":1751494507000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-73344-9_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319733432","9783319733449"],"references-count":263,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-73344-9_7","relation":{},"subject":[],"published":{"date-parts":[[2018]]}}}