{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:22:59Z","timestamp":1739510579126,"version":"3.37.0"},"publisher-location":"Dordrecht","reference-count":136,"publisher":"Springer Netherlands","isbn-type":[{"type":"print","value":"9789048131433"},{"type":"electronic","value":"9789048131440"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-90-481-3144-0_9","type":"book-chapter","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T19:03:30Z","timestamp":1259607810000},"page":"165-188","source":"Crossref","is-referenced-by-count":4,"title":["Adenosine A3 Receptor Signaling in the Central Nervous System"],"prefix":"10.1007","author":[{"given":"Felicita","family":"Pedata","sequence":"first","affiliation":[]},{"given":"Anna Maria","family":"Pugliese","sequence":"additional","affiliation":[]},{"given":"Ana M.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[]},{"given":"Joaquim A.","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,11,6]]},"reference":[{"issue":"6","key":"9_CR1_9","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0026-895X(25)10571-3","volume":"48","author":"MP Abbracchio","year":"1995","unstructured":"Abbracchio MP, Brambilla R, Ceruti S, Kim HO, von Lubitz DK, Jacobson KA, Cattabeni F (1995) G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. Mol Pharmacol 48(6):1038\u20131045","journal-title":"Mol Pharmacol"},{"key":"9_CR2_9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1749-6632.1997.tb48410.x","volume":"825","author":"MP Abbracchio","year":"1997","unstructured":"Abbracchio MP, Ceruti S, Brambilla R, Franceschi C, Malorni W, Jacobson KA, von Lubitz DK, Cattabeni F (1997) Modulation of apoptosis by adenosine in the central nervous system: a possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders. Ann N Y Acad Sci 825:11\u201322","journal-title":"Ann N Y Acad Sci"},{"key":"9_CR3_9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1749-6632.2001.tb03613.x","volume":"939","author":"MP Abbracchio","year":"2001","unstructured":"Abbracchio MP, Camurri A, Ceruti S, Cattabeni F, Falzano L, Giammarioli AM, Jacobson KA, Trincavelli L, Martini C, Malorni W, Fiorentini C (2001) The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins. Ann N Y Acad Sci 939:63\u201373","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"9_CR4_9","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/sj.bjp.0705707","volume":"141","author":"S Alloisio","year":"2004","unstructured":"Alloisio S, Cugnoli C, Ferroni S, Nobile M (2004) Differential modulation of ATP-induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes. Br J Pharmacol 141(6):935\u2013942","journal-title":"Br J Pharmacol"},{"issue":"3","key":"9_CR5_9","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1385\/JMN:17:3:285","volume":"17","author":"E Appel","year":"2001","unstructured":"Appel E, Kazimirsky G, Ashkenazi E, Kim SG, Jacobson KA, Brodie C (2001) Roles of BCL-2 and caspase 3 in the adenosine A3 receptor-induced apoptosis. J Mol Neurosci 17(3):285\u2013292","journal-title":"J Mol Neurosci"},{"issue":"2","key":"9_CR6_9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/(SICI)1098-1128(200003)20:2<103::AID-MED1>3.0.CO;2-X","volume":"20","author":"PG Baraldi","year":"2000","unstructured":"Baraldi PG, Cacciari B, Romagnoli R, Merighi S, Varani K, Borea PA, Spalluto G (2000) A(3) adenosine receptor ligands: history and perspectives. Med Res Rev 20(2):103\u2013128","journal-title":"Med Res Rev"},{"issue":"5","key":"9_CR7_9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.physbeh.2008.09.018","volume":"95","author":"O Bjorklund","year":"2008","unstructured":"Bjorklund O, Halldner-Henriksson L, Yang J, Eriksson TM, Jacobson MA, Dare E, Fredholm BB (2008a) Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice. Physiol Behav 95(5):668\u2013676","journal-title":"Physiol Behav"},{"issue":"1\u20133","key":"9_CR8_9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ejphar.2008.08.002","volume":"596","author":"O Bjorklund","year":"2008","unstructured":"Bjorklund O, Shang M, Tonazzini I, Dare E, Fredholm BB (2008b) Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. Eur J Pharmacol 596(1\u20133):6\u201313","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"9_CR9_9","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1358\/dnp.2007.20.10.1181353","volume":"20","author":"D Boison","year":"2007","unstructured":"Boison D (2007) Adenosine as a modulator of brain activity. Drug News Perspect 20(10):607\u2013611","journal-title":"Drug News Perspect"},{"issue":"3","key":"9_CR10_9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pneurobio.2007.12.002","volume":"84","author":"D Boison","year":"2008","unstructured":"Boison D (2008) The adenosine kinase hypothesis of epileptogenesis. Prog Neurobiol 84(3):249\u2013262","journal-title":"Prog Neurobiol"},{"issue":"2\u20133","key":"9_CR11_9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0014-2999(97)89651-3","volume":"327","author":"KK Borowicz","year":"1997","unstructured":"Borowicz KK, Kleinrok Z, Czuczwar SJ (1997) N6-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive activity of antiepileptic drugs. Eur J Pharmacol 327(2\u20133):125\u2013133","journal-title":"Eur J Pharmacol"},{"key":"9_CR12_9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0028-3908(00)00117-9","volume":"40","author":"A Brand","year":"2001","unstructured":"Brand A, Vissiennon Z, Eschke D, Nieber K (2001) Adenosine A(1) and A(3) receptors mediate inhibition of synaptic transmission in rat cortical neurons. Neuropharmacology 40:85\u201395","journal-title":"Neuropharmacology"},{"issue":"8","key":"9_CR13_9","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1002\/jnr.21071","volume":"84","author":"GJ Chen","year":"2006","unstructured":"Chen GJ, Harvey BK, Shen H, Chou J, Victor A, Wang Y (2006) Activation of adenosine A3 receptors reduces ischemic brain injury in rodents. J Neurosci Res 84(8):1848\u20131855","journal-title":"J Neurosci Res"},{"issue":"15","key":"9_CR14_9","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.2174\/138161208784480126","volume":"14","author":"JF Chen","year":"2008","unstructured":"Chen JF, Pedata F (2008) Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors. Curr Pharm Des 14(15):1490\u20131499","journal-title":"Curr Pharm Des"},{"issue":"5","key":"9_CR15_9","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.pneurobio.2007.09.002","volume":"83","author":"JF Chen","year":"2007","unstructured":"Chen JF, Sonsalla PK, Pedata F, Melani A, Domenici MR, Popoli P, Geiger J, Lopes LV, de Mendonca A (2007) Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and \u201cfine tuning\u201d modulation. Prog Neurobiol 83(5):310\u2013331","journal-title":"Prog Neurobiol"},{"issue":"2","key":"9_CR16_9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/jnr.1141","volume":"65","author":"Y Chen","year":"2001","unstructured":"Chen Y, Rathbone MP, Hertz L (2001) Guanosine-induced increase in free cytosolic calcium concentration in mouse astrocytes in primary cultures: does it act on an A3 adenosine receptor? J Neurosci Res 65(2):184\u2013189","journal-title":"J Neurosci Res"},{"issue":"17","key":"9_CR17_9","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1021\/jm070123v","volume":"50","author":"V Colotta","year":"2007","unstructured":"Colotta V, Catarzi D, Varano F, Capelli F, Lenzi O, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Pugliese AM, Pedata F, Schiesaro A, Morizzo E, Moro S (2007) New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand\u2013receptor modeling studies. J Med Chem 50(17):4061\u20134074","journal-title":"J Med Chem"},{"issue":"11","key":"9_CR18_9","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.bmc.2008.04.039","volume":"16","author":"V Colotta","year":"2008","unstructured":"Colotta V, Catarzi D, Varano F, Lenzi O, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Traini C, Pugliese AM, Pedata F, Morizzo E, Moro S (2008) Synthesis, ligand\u2013receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists Bioorg Med Chem 16(11):6086\u20136102","journal-title":"Bioorg Med Chem"},{"issue":"1\u20132","key":"9_CR19_9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0014-2999(84)90364-9","volume":"104","author":"R Corradetti","year":"1984","unstructured":"Corradetti R, Lo CG, Moroni F, Passani MB, Pepeu G (1984) Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur J Pharmacol 104(1\u20132):19\u201326","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"9_CR20_9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0304-3940(01)01633-0","volume":"302","author":"AR Costenla","year":"2001","unstructured":"Costenla AR, Lopes LV, de Mendonca A, Ribeiro JA (2001) A functional role for adenosine A3 receptors: modulation of synaptic plasticity in the rat hippocampus. Neurosci Lett 302(1):53\u201357","journal-title":"Neurosci Lett"},{"issue":"11","key":"9_CR21_9","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1097\/00001756-199507310-00029","volume":"6","author":"RA Cunha","year":"1995","unstructured":"Cunha RA, Constantino MC, Sebasti\u00e3o AM, Ribeiro JA (1995) Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport 6(11):1583\u20131588","journal-title":"Neuroreport"},{"issue":"3","key":"9_CR22_9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF00168627","volume":"353","author":"RA Cunha","year":"1996","unstructured":"Cunha RA, Johansson B, Constantino MD, Sebasti\u00e3o AM, Fredholm BB (1996a) Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn Schmiedebergs Arch Pharmacol 353(3):261\u2013271","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"9_CR23_9","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1046\/j.1471-4159.1996.67052180.x","volume":"67","author":"RA Cunha","year":"1996","unstructured":"Cunha RA, Vizi ES, Ribeiro JA, Sebasti\u00e3o AM (1996b) Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J Neurochem 67(5):2180\u20132187","journal-title":"J Neurochem"},{"issue":"8","key":"9_CR24_9","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/00001756-199505300-00006","volume":"6","author":"A Mendonca de","year":"1995","unstructured":"de Mendonca A, Sebasti\u00e3o AM, Ribeiro JA (1995) Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation. Neuroreport 6(8):1097\u20131100","journal-title":"Neuroreport"},{"issue":"2","key":"9_CR25_9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3940(00)01391-4","volume":"291","author":"A Mendonca","year":"2000","unstructured":"de Mendonca A, Ribeiro JA (2000) Long-term potentiation observed upon blockade of adenosine A1 receptors in rat hippocampus is N-methyl-D-aspartate receptor-dependent. Neurosci.Lett 291(2):81\u201384","journal-title":"Neurosci.Lett"},{"issue":"2\u20133","key":"9_CR26_9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0014-2999(99)00132-6","volume":"371","author":"G Sarro De","year":"1999","unstructured":"De Sarro G, De Sarro A, Di Paola ED, Bertorelli R (1999) Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA\/2 mice. Eur J Pharmacol 371(2\u20133):137\u2013145","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"9_CR27_9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0165-3806(88)90251-9","volume":"470","author":"J Deckert","year":"1988","unstructured":"Deckert J, Morgan PF, Daval JL, Nakajima T, Marangos PJ (1988) Ontogeny of adenosine uptake sites in guinea pig brain: differential profile of [3H]nitrobenzylthioinosine and [3H]dipyridamole binding sites. Brain Res 470(2):313\u2013316","journal-title":"Brain Res"},{"issue":"2","key":"9_CR28_9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-3565(25)22108-5","volume":"246","author":"GE DeLander","year":"1988","unstructured":"DeLander GE, Wahl JJ (1988) Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally. J Pharmacol Exp Ther 246(2):565\u2013570","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"9_CR29_9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/glia.10055","volume":"38","author":"P Iorio Di","year":"2002","unstructured":"Di Iorio P, Kleywegt S, Ciccarelli R, Traversa U, Andrew CM, Crocker CE, Werstiuk ES, Rathbone MP (2002) Mechanisms of apoptosis induced by purine nucleosides in astrocytes. Glia 38(3):179\u2013190","journal-title":"Glia"},{"issue":"9","key":"9_CR30_9","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","volume":"22","author":"U Dirnagl","year":"1999","unstructured":"Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22(9):391\u2013397","journal-title":"Trends Neurosci"},{"issue":"6","key":"9_CR31_9","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1476-5381.1996.tb15561.x","volume":"118","author":"AK Dixon","year":"1996","unstructured":"Dixon AK, Gubitz AK, Sirinathsinghji DJ, Richardson PJ, Freeman TC (1996) Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol 118(6):1461\u20131468","journal-title":"Br J Pharmacol"},{"issue":"5","key":"9_CR32_9","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1528-1157.1985.tb05684.x","volume":"26","author":"M Dragunow","year":"1985","unstructured":"Dragunow M, Goddard GV, Laverty R (1985) Is adenosine an endogenous anticonvulsant? Epilepsia 26(5):480\u2013487","journal-title":"Epilepsia"},{"issue":"5","key":"9_CR33_9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/ana.410290524","volume":"29","author":"M Dragunow","year":"1991","unstructured":"Dragunow M (1991) Adenosine and seizure termination. Ann Neurol 29(5):575","journal-title":"Ann Neurol"},{"issue":"7","key":"9_CR34_9","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1523\/JNEUROSCI.13-07-02910.1993","volume":"13","author":"SM Dudek","year":"1993","unstructured":"Dudek SM, Bear MF (1993) Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J Neurosci 13(7):2910\u20132918","journal-title":"J Neurosci"},{"issue":"5","key":"9_CR35_9","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.1528-1157.1980.tb04305.x","volume":"21","author":"TV Dunwiddie","year":"1980","unstructured":"Dunwiddie TV (1980) Endogenously released adenosine regulates excitability in the in vitro hippocampus. Epilepsia 21(5):541\u2013548","journal-title":"Epilepsia"},{"issue":"2","key":"9_CR36_9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1523\/JNEUROSCI.17-02-00607.1997","volume":"17","author":"TV Dunwiddie","year":"1997","unstructured":"Dunwiddie TV, Diao L, Kim HO, Jiang JL, Jacobson KA (1997) Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. J Neurosci 17(2):607\u2013614","journal-title":"J Neurosci"},{"issue":"5","key":"9_CR37_9","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/ana.410320504","volume":"32","author":"MJ During","year":"1992","unstructured":"During MJ, Spencer DD (1992) Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol 32(5):618\u2013624","journal-title":"Ann Neurol"},{"issue":"9","key":"9_CR38_9","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1111\/j.0953-816X.2004.03355.x","volume":"19","author":"LA Etherington","year":"2004","unstructured":"Etherington LA, Frenguelli BG (2004) Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. Eur J Neurosci 19(9):2539\u20132550","journal-title":"Eur J Neurosci"},{"issue":"3","key":"9_CR39_9","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1023\/A:1023601007518","volume":"23","author":"IM Fedorova","year":"2003","unstructured":"Fedorova IM, Jacobson MA, Basile A, Jacobson KA (2003) Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration. Cell Mol Neurobiol 23(3):431\u2013447","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"9_CR40_9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/(SICI)1098-1136(199610)18:2<152::AID-GLIA7>3.0.CO;2-2","volume":"18","author":"BL Fiebich","year":"1996","unstructured":"Fiebich BL, Biber K, Lieb K, van Calker D, Berger M, Bauer J, Gebicke-Haerter PJ (1996) Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors. Glia 18(2):152\u2013160","journal-title":"Glia"},{"issue":"3","key":"9_CR41_9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0028-3908(97)83762-8","volume":"36","author":"KM Fleming","year":"1997","unstructured":"Fleming KM, Mogul DJ (1997) Adenosine A3 receptors potentiate hippocampal calcium current by a PKA-dependent\/PKC-independent pathway. Neuropharmacology 36(3):353\u2013362","journal-title":"Neuropharmacology"},{"issue":"1","key":"9_CR42_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1476-5381.1993.tb13522.x","volume":"109","author":"JR Fozard","year":"1993","unstructured":"Fozard JR, Carruthers AM (1993). Adenosine A3 receptors mediate hypotension in the angiotensin II-supported circulation of the pithed rat. Br J Pharmacol 109(1):3\u20135","journal-title":"Br J Pharmacol"},{"issue":"3","key":"9_CR43_9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0014-2999(95)00822-5","volume":"298","author":"JR Fozard","year":"1996","unstructured":"Fozard JR, Pfannkuche HJ, Schuurman HJ (1996). Mast cell degranulation following adenosine A3 receptor activation in rats. Eur J Pharmacol 298(3):293\u2013297","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"9_CR44_9","first-page":"527","volume":"53","author":"BB Fredholm","year":"2001","unstructured":"Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53(4):527\u2013552","journal-title":"XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev"},{"issue":"1","key":"9_CR45_9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/mol.59.1.76","volume":"59","author":"Z Gao","year":"2001","unstructured":"Gao Z, Li BS, Day YJ, Linden J (2001) A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Mol Pharmacol 59(1):76\u201382","journal-title":"Mol Pharmacol"},{"issue":"3","key":"9_CR46_9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1517\/14728214.12.3.479","volume":"12","author":"ZG Gao","year":"2007","unstructured":"Gao ZG, Jacobson KA (2007) Emerging adenosine receptor agonists. Expert Opin Emerg Drugs 12(3):479\u2013492","journal-title":"Expert Opin Emerg Drugs"},{"issue":"1","key":"9_CR47_9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.pharmthera.2007.09.002","volume":"117","author":"S Gessi","year":"2008","unstructured":"Gessi S, Merighi S, Varani K, Leung E, Mac Lennan S, Borea PA (2008) The A3 adenosine receptor: an enigmatic player in cell biology. Pharmacol Ther 117(1):123\u2013140","journal-title":"Pharmacol Ther"},{"issue":"3","key":"9_CR48_9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/jphysiol.1972.sp009916","volume":"224","author":"BL Ginsborg","year":"1972","unstructured":"Ginsborg BL, Hirst GD (1972) The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat. J Physiol 224(3):629\u2013645","journal-title":"J Physiol"},{"issue":"4","key":"9_CR49_9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0301-0082(91)90005-L","volume":"36","author":"RW Greene","year":"1991","unstructured":"Greene RW, Haas HL (1991) The electrophysiology of adenosine in the mammalian central nervous system. Prog Neurobiol 36(4):329\u2013341","journal-title":"Prog Neurobiol"},{"issue":"1","key":"9_CR50_9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1471-4159.1987.tb03419.x","volume":"49","author":"H Hagberg","year":"1987","unstructured":"Hagberg H, Andersson P, Lacarewicz J, Jacobson I, Butcher S, Sandberg M (1987) Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J Neurochem 49(1):227\u2013231","journal-title":"J Neurochem"},{"issue":"4","key":"9_CR51_9","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1046\/j.1471-4159.2003.01919.x","volume":"86","author":"C Hammarberg","year":"2003","unstructured":"Hammarberg C, Schulte G, Fredholm BB (2003) Evidence for functional adenosine A3 receptors in microglia cells. J Neurochem 86(4):1051\u20131054","journal-title":"J Neurochem"},{"issue":"1","key":"9_CR52_9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bcp.2003.08.031","volume":"67","author":"C Hammarberg","year":"2004","unstructured":"Hammarberg C, Fredholm BB, Schulte G (2004) Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1\/2 via phosphatidylinositol-3\u2019-kinase. Biochem Pharmacol 67(1):129\u2013134","journal-title":"Biochem Pharmacol"},{"issue":"1\u20132","key":"9_CR53_9","first-page":"55","volume":"21","author":"S Hentschel","year":"2003","unstructured":"Hentschel S, Lewerenz A, Nieber K (2003) Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons. Restor Neurol Neurosci 21(1\u20132):55\u201363","journal-title":"Restor Neurol Neurosci"},{"issue":"11","key":"9_CR54_9","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1523\/JNEUROSCI.4247-06.2007","volume":"27","author":"CC Huang","year":"2007","unstructured":"Huang CC, Yang PC, Lin HJ, Hsu KS (2007) Repeated cocaine administration impairs group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex. J Neurosci 27(11):2958\u20132968","journal-title":"J Neurosci"},{"issue":"1","key":"9_CR55_9","first-page":"57","volume":"336","author":"KA Jacobson","year":"1993","unstructured":"Jacobson KA, Nikodijevic O, Shi D, Gallo-Rodriguez C, Olah ME, Stiles GL, Daly JW (1993) A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett 336(1):57\u201360","journal-title":"Mediation of behavioral depressant effects. FEBS Lett"},{"issue":"10","key":"9_CR56_9","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1021\/jm00010a017","volume":"38","author":"KA Jacobson","year":"1995","unstructured":"Jacobson KA, Siddiqi SM, Olah ME, Ji XD, Melman N, Bellamkonda K, Meshulam Y, Stiles GL, Kim HO (1995) Structure\u2013activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors. J Med Chem 38(10):1720\u20131735","journal-title":"J Med Chem"},{"issue":"5","key":"9_CR57_9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S0165-6147(98)01203-6","volume":"19","author":"KA Jacobson","year":"1998","unstructured":"Jacobson KA (1998). Adenosine A3 receptors: novel ligands and paradoxical effects. Trends Pharmacol Sci 19(5):184\u2013191","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"9_CR58_9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1023\/A:1009666707307","volume":"4","author":"KA Jacobson","year":"1999","unstructured":"Jacobson KA, Hoffmann C, Cattabeni F, Abbracchio MP (1999) Adenosine-induced cell death: evidence for receptor-mediated signalling. Apoptosis 4(3):197\u2013211","journal-title":"Apoptosis"},{"issue":"2\u20133","key":"9_CR59_9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0014-2999(95)00668-0","volume":"295","author":"SH Kafka","year":"1996","unstructured":"Kafka SH, Corbett R (1996) Selective adenosine A2A receptor\/dopamine D2 receptor interactions in animal models of schizophrenia. Eur J Pharmacol 295(2\u20133):147\u2013154","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"9_CR60_9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0006-8993(98)00304-7","volume":"794","author":"S Latini","year":"1998","unstructured":"Latini S, Bordoni F, Corradetti R, Pepeu G, Pedata F (1998) Temporal correlation between adenosine outflow and synaptic potential inhibition in rat hippocampal slices during ischemia-like conditions. Brain Res., 794, (2) 325-328.","journal-title":"Brain Res."},{"issue":"3","key":"9_CR61_9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1046\/j.1471-4159.2001.00607.x","volume":"79","author":"S Latini","year":"2001","unstructured":"Latini S, Pedata F (2001) Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem 79(3):463\u2013484","journal-title":"J Neurochem"},{"issue":"2\u20133","key":"9_CR62_9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.eplepsyres.2004.03.005","volume":"59","author":"MA Laudadio","year":"2004","unstructured":"Laudadio MA, Psarropoulou C (2004) The A3 adenosine receptor agonist 2-Cl-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices. Epilepsy Res 59(2\u20133):83\u201394","journal-title":"Epilepsy Res"},{"issue":"1","key":"9_CR63_9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/0006-8993(84)90694-2","volume":"321","author":"KS Lee","year":"1984","unstructured":"Lee KS, Schubert P, Heinemann U (1984) The anticonvulsive action of adenosine: a postsynaptic, dendritic action by a possible endogenous anticonvulsant. Brain Res 321(1):160\u2013164","journal-title":"Brain Res"},{"issue":"1\u20132","key":"9_CR64_9","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0006-8993(93)90888-T","volume":"609","author":"KS Lee","year":"1993","unstructured":"Lee KS, Lowenkopf T (1993) Endogenous adenosine delays the onset of hypoxic depolarization in the rat hippocampus in vitro via an action at A1 receptors. Brain Res 609(1\u20132):313\u2013315","journal-title":"Brain Res"},{"issue":"1","key":"9_CR65_9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2005.11.004","volume":"396","author":"JY Lee","year":"2006","unstructured":"Lee JY, Jhun BS, Oh YT, Lee JH, Choe W, Baik HH, Ha J, Yoon KS, Kim SS, Kang I (2006) Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase\/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci Lett 396(1):1\u20136","journal-title":"Neurosci Lett"},{"issue":"2","key":"9_CR66_9","first-page":"571","volume":"118","author":"T Li","year":"2008","unstructured":"Li T, Ren G, Lusardi T, Wilz A, Lan JQ, Iwasato T, Itohara S, Simon RP, Boison D (2008) Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest 118(2):571\u2013582","journal-title":"J Clin Invest"},{"issue":"Pt 5","key":"9_CR67_9","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/brain\/awm057","volume":"130","author":"T Li","year":"2007","unstructured":"Li T, Steinbeck JA, Lusardi T, Koch P, Lan JQ, Wilz A, Segschneider M, Simon RP, Brustle O, Boison D (2007) Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain 130 Pt 5:1276\u20131288","journal-title":"Brain"},{"issue":"12","key":"9_CR68_9","doi-asserted-by":"publisher","first-page":"6995","DOI":"10.1073\/pnas.95.12.6995","volume":"95","author":"BT Liang","year":"1998","unstructured":"Liang BT, Jacobson KA (1998) A physiological role of the adenosine A3 receptor: sustained cardioprotection. Proc Natl Acad Sci U S A 95(12):6995\u20136999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"9_CR69_9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0026-895X(25)13220-3","volume":"44","author":"J Linden","year":"1993","unstructured":"Linden J, Taylor HE, Robeva AS, Tucker AL, Stehle JH, Rivkees SA, Fink JS, Reppert SM (1993) Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Mol Pharmacol 44(3):524\u2013532","journal-title":"Mol Pharmacol"},{"issue":"5","key":"9_CR70_9","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1073\/pnas.77.5.2551","volume":"77","author":"C Londos","year":"1980","unstructured":"Londos C, Cooper DM, Wolff J (1980) Subclasses of external adenosine receptors. Proc Natl Acad Sci U S A 77(5):2551\u20132554","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"9_CR71_9","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1097\/00001756-200308260-00021","volume":"14","author":"LV Lopes","year":"2003","unstructured":"Lopes LV, Rebola N, Pinheiro PC, Richardson PJ, Oliveira CR, Cunha RA (2003) Adenosine A3 receptors are located in neurons of the rat hippocampus. Neuroreport 14 (12):1645\u20131648","journal-title":"Neuroreport"},{"issue":"16","key":"9_CR72_9","doi-asserted-by":"crossref","first-page":"6138","DOI":"10.1523\/JNEUROSCI.18-16-06138.1998","volume":"18","author":"TA Macek","year":"1998","unstructured":"Macek TA, Schaffhauser H, Conn PJ (1998) Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins. J Neurosci 18(16):6138\u20136146","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"9_CR73_9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0014-2999(01)01619-3","volume":"441","author":"A Mauborgne","year":"2002","unstructured":"Mauborgne A, Polienor H, Hamon M, Cesselin F, Bourgoin S (2002) Adenosine receptor-mediated control of in vitro release of pain-related neuropeptides from the rat spinal cord. Eur J Pharmacol 441(1\u20132) 47\u201355","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"9_CR74_9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0014-5793(91)80674-R","volume":"284","author":"W Meyerhof","year":"1991","unstructured":"Meyerhof W, Muller-Brechlin R, Richter, D (1991a) Molecular cloning of a novel putative G-protein coupled receptor expressed during rat spermiogenesis. FEBS Lett 284(2):155\u2013160","journal-title":"FEBS Lett"},{"issue":"9","key":"9_CR75_9","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1089\/dna.1991.10.689","volume":"10","author":"W Meyerhof","year":"1991","unstructured":"Meyerhof W, Paust HJ, Schonrock C, Richter D (1991b) Cloning of a cDNA encoding a novel putative G-protein-coupled receptor expressed in specific rat brain regions. DNA Cell Biol 10(9):689\u2013694","journal-title":"DNA Cell Biol"},{"issue":"44","key":"9_CR76_9","doi-asserted-by":"crossref","first-page":"27351","DOI":"10.1016\/S0021-9258(18)46992-X","volume":"269","author":"KJ Miller","year":"1994","unstructured":"Miller KJ, Hoffman BJ (1994) Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP. J Biol Chem 269(44):27351\u201327356","journal-title":"J Biol Chem"},{"issue":"2","key":"9_CR77_9","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1006\/brcg.1996.0041","volume":"31","author":"D Neary","year":"1996","unstructured":"Neary D, Snowden J (1996) Fronto-temporal dementia: nosology, neuropsychology, and neuropathology. Brain Cogn 31(2):176\u2013187","journal-title":"Brain Cogn"},{"key":"9_CR78_9","unstructured":"Nieber K, Hentschel S (2006) Signalling pathways of the adenosine A3 receptors in rat cortical neurons. In: Proceedings of the 8th international symposium on adenosine and adenine nucleotides, Ferrara, Italy, 24\u201328 May 2006"},{"issue":"6","key":"9_CR79_9","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1046\/j.1471-4159.1997.69062581.x","volume":"69","author":"M Okada","year":"1997","unstructured":"Okada M, Kawata Y, Kiryu K, Mizuno K, Wada K, Tasaki H, Kaneko S (1997) Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. J Neurochem 69(6):2581\u20132588","journal-title":"J Neurochem"},{"issue":"1","key":"9_CR80_9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1460-9568.1999.00415.x","volume":"11","author":"M Okada","year":"1999","unstructured":"Okada M, Kawata Y, Murakami T, Wada K, Mizuno K, Kondo T, Kaneko S (1999) Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin. Eur J Neurosci 11(1):1\u20139","journal-title":"Eur J Neurosci"},{"issue":"4","key":"9_CR81_9","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/j.1471-4159.1991.tb08275.x","volume":"57","author":"JC Oliveira","year":"1991","unstructured":"Oliveira JC, Sebasti\u00e3o AM, Ribeiro JA (1991) Solubilized rat brain adenosine receptors have two high-affinity binding sites for 1,3-dipropyl-8-cyclopentylxanthine. J Neurochem 57(4):1165\u20131171","journal-title":"J Neurochem"},{"issue":"49","key":"9_CR82_9","first-page":"29607","volume":"270","author":"TM Palmer","year":"1995","unstructured":"Palmer TM, Benovic JL, Stiles GL (1995) Agonist-dependent phosphorylation and desensitization of the rat A3 adenosine receptor. Evidence for a G-protein-coupled receptor kinase-mediated mechanism. J Biol Chem 270(49):29607\u201329613","journal-title":"Evidence for a G-protein-coupled receptor kinase-mediated mechanism. J Biol Chem"},{"issue":"5","key":"9_CR83_9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/jcbfm.1987.116","volume":"7","author":"TS Park","year":"1987","unstructured":"Park TS, Van Wylen DG, Rubio R, Berne RM (1987) Interstitial fluid adenosine and sagittal sinus blood flow during bicuculline-seizures in newborn piglets. J Cereb Blood Flow Metab 7(5):633\u2013639","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"9_CR84_9","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1111\/j.1471-4159.2006.03823.x","volume":"97","author":"T Pearson","year":"2006","unstructured":"Pearson T, Damian K, Lynas RE, Frenguelli BG (2006) Sustained elevation of extracellular adenosine and activation of A1 receptors underlie the post-ischaemic inhibition of neuronal function in rat hippocampus in vitro. J Neurochem 97(5):1357\u20131368","journal-title":"J Neurochem"},{"issue":"1\u20132","key":"9_CR85_9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0006-8993(98)00430-2","volume":"798","author":"JG Pilitsis","year":"1998","unstructured":"Pilitsis JG, Kimelberg HK (1998) Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes. Brain Res 798(1\u20132):294\u2013303","journal-title":"Brain Res"},{"issue":"2","key":"9_CR86_9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/sj.bjp.0705442","volume":"140","author":"AM Pugliese","year":"2003","unstructured":"Pugliese AM, Latini S, Corradetti R, Pedata F (2003) Brief, repeated, oxygen\u2013glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors. Br J Pharmacol 140(2):305\u2013314","journal-title":"Br J Pharmacol"},{"issue":"5","key":"9_CR87_9","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/sj.bjp.0706646","volume":"147","author":"AM Pugliese","year":"2006","unstructured":"Pugliese AM, Coppi E, Spalluto G, Corradetti R, Pedata F (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147(5):524\u2013532","journal-title":"Br J Pharmacol"},{"issue":"5","key":"9_CR88_9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.bcp.2007.06.003","volume":"74","author":"AM Pugliese","year":"2007","unstructured":"Pugliese AM, Coppi E, Volpini R, Cristalli G, Corradetti R, Jeong LS, Jacobson KA, Pedata F (2007) Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen\u2013glucose deprivation episodes of different duration. Biochem Pharmacol 74(5)768\u2013779","journal-title":"Biochem Pharmacol"},{"issue":"23","key":"9_CR89_9","doi-asserted-by":"crossref","first-page":"16887","DOI":"10.1016\/S0021-9258(19)85277-8","volume":"268","author":"V Ramkumar","year":"1993","unstructured":"Ramkumar V, Stiles GL, Beaven MA, Ali H (1993) The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J Biol Chem 268(23):16887\u201316890","journal-title":"J Biol Chem"},{"issue":"5","key":"9_CR90_9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.neuint.2005.05.009","volume":"47","author":"N Rebola","year":"2005","unstructured":"Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA (2005) Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons. Neurochem Int 47(5):317\u2013325","journal-title":"Neurochem Int"},{"issue":"1","key":"9_CR91_9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neuron.2007.11.023","volume":"57","author":"N Rebola","year":"2008","unstructured":"Rebola N, Lujan R, Cunha RA, Mulle C (2008) Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57(1):121\u2013134","journal-title":"Neuron"},{"issue":"5","key":"9_CR92_9","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s000110050169","volume":"46","author":"JJ Reeves","year":"1997","unstructured":"Reeves JJ, Jones CA, Sheehan MJ, Vardey CJ, Whelan CJ (1997) Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and in vivo. Inflamm Res 46(5):180\u2013184","journal-title":"Inflamm Res"},{"issue":"2","key":"9_CR93_9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.1975.tb06931.x","volume":"54","author":"JA Ribeiro","year":"1975","unstructured":"Ribeiro JA, Walker J (1975) The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions. Br J Pharmacol 54(2):213\u2013218","journal-title":"Br J Pharmacol"},{"issue":"2","key":"9_CR94_9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1476-5381.1984.tb16511.x","volume":"83","author":"JA Ribeiro","year":"1984","unstructured":"Ribeiro JA, Sebasti\u00e3o AM (1984) Enhancement of tetrodotoxin-induced axonal blockade by adenosine, adenosine analogues, dibutyryl cyclic AMP and methylxanthines in the frog sciatic nerve. Br J Pharmacol 83(2):485\u2013492","journal-title":"Br J Pharmacol"},{"issue":"3","key":"9_CR95_9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0301-0082(86)90015-8","volume":"26","author":"JA Ribeiro","year":"1986","unstructured":"Ribeiro JA, Sebasti\u00e3o AM (1986) Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor. Prog Neurobiol 26(3):179\u2013209","journal-title":"Prog Neurobiol"},{"issue":"6","key":"9_CR96_9","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1210\/en.135.6.2307","volume":"135","author":"SA Rivkees","year":"1994","unstructured":"Rivkees SA (1994) Localization and characterization of adenosine receptor expression in rat testis. Endocrinology 135(6):2307\u20132313","journal-title":"Endocrinology"},{"issue":"5","key":"9_CR97_9","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1097\/00001756-200004070-00026","volume":"11","author":"SA Rivkees","year":"2000","unstructured":"Rivkees SA, Thevananther S, Hao H (2000) Are A3 adenosine receptors expressed in the brain? Neuroreport 11(5):1025\u20131030","journal-title":"Neuroreport"},{"issue":"39","key":"9_CR98_9","doi-asserted-by":"publisher","first-page":"15118","DOI":"10.1073\/pnas.0807277105","volume":"105","author":"C Roseti","year":"2008","unstructured":"Roseti C, Martinello K, Fucile S, Piccari V, Mascia A, Di Gennaro G, Quarato PP, Manfredi M, Esposito V, Cantore G, Arcella A, Simonato M, Fredholm BB, Limatola C, Miledi R, Eusebi F (2008) Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors. Proc Natl Acad Sci U S A 105(39):15118\u201315123","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"9_CR99_9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0166-4328(02)00314-5","volume":"141","author":"A Rubaj","year":"2003","unstructured":"Rubaj A, Zgodzinski W, Sieklucka-Dziuba M (2003) The influence of adenosine A3 receptor agonist: IB-MECA, on scopolamine- and MK-801-induced memory impairment. Behav Brain Res 141(1):11\u201317","journal-title":"Behav Brain Res"},{"issue":"21","key":"9_CR100_9","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1073\/pnas.90.21.10365","volume":"90","author":"CA Salvatore","year":"1993","unstructured":"Salvatore CA, Jacobson MA, Taylor HE, Linden J, Johnson RG (1993) Molecular cloning and characterization of the human A3 adenosine receptor. Proc Natl Acad Sci U S A 90(21):10365\u201310369","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9_CR101_9","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1074\/jbc.275.6.4429","volume":"275","author":"CA Salvatore","year":"2000","unstructured":"Salvatore CA, Tilley SL, Latour AM, Fletcher DS, Koller BH, Jacobson MA (2000) Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells. J Biol Chem 275(6):4429\u20134434","journal-title":"J Biol Chem"},{"issue":"1","key":"9_CR102_9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/BF00582948","volume":"406","author":"G Sanderson","year":"1986","unstructured":"Sanderson G, Scholfield CN (1986) Effects of adenosine uptake blockers and adenosine on evoked potentials of guinea-pig olfactory cortex. Pflugers Arch 406(1):25\u201330","journal-title":"Pflugers Arch"},{"issue":"1","key":"9_CR103_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0026-895X(25)15197-3","volume":"6","author":"A Sattin","year":"1970","unstructured":"Sattin A, Rall TW (1970) The effect of adenosine and adenine nucleotides on the cyclic adenosine 3\u2032, 5\u2032-phosphate content of guinea pig cerebral cortex slices. Mol Pharmacol 6(1):13\u201323","journal-title":"Mol Pharmacol"},{"issue":"1","key":"9_CR104_9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(97)01110-2","volume":"333","author":"J Sawynok","year":"1997","unstructured":"Sawynok J, Zarrindast MR, Reid AR, Doak GJ (1997) Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. Eur J Pharmacol 333(1):1\u20137","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"9_CR105_9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(97)01605-1","volume":"347","author":"J Sawynok","year":"1998","unstructured":"Sawynok J (1998) Adenosine receptor activation and nociception. Eur J Pharmacol 347(1):1\u201311","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"9_CR106_9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0304-3959(98)00195-X","volume":"80","author":"J Sawynok","year":"1999","unstructured":"Sawynok J, Reid AR, Esser MJ (1999) Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine. Pain 80(1\u20132):45\u201355","journal-title":"Pain"},{"issue":"21","key":"9_CR107_9","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1523\/JNEUROSCI.21-21-08564.2001","volume":"21","author":"AM Sebasti\u00e3o","year":"2001","unstructured":"Sebasti\u00e3o AM, de Mendonca A, Moreira T, Ribeiro JA (2001) Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation. J Neurosci 21(21):8564\u20138571","journal-title":"J Neurosci"},{"issue":"3","key":"9_CR108_9","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1161\/01.STR.0000155747.15679.04","volume":"36","author":"H Shen","year":"2005","unstructured":"Shen H, Chen GJ, Harvey BK, Bickford PC, Wang Y (2005) Inosine reduces ischemic brain injury in rats. Stroke 36(3):654\u2013659","journal-title":"Stroke"},{"issue":"3","key":"9_CR109_9","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1097\/00000539-199709000-00025","volume":"85","author":"KF Sjolund","year":"1997","unstructured":"Sjolund KF, Sollevi A, Segerdahl M, Lundeberg T (1997) Intrathecal adenosine analog administration reduces substance P in cerebrospinal fluid along with behavioral effects that suggest antinociception in rats. Anesth Analg 85(3):627\u2013632","journal-title":"Anesth Analg"},{"issue":"3","key":"9_CR110_9","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/physrev.2001.81.3.1065","volume":"81","author":"GG Somjen","year":"2001","unstructured":"Somjen GG (2001) Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev 81(3):1065\u20131096","journal-title":"Physiol Rev"},{"issue":"3","key":"9_CR111_9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/sj.bjp.0702126","volume":"125","author":"L Stella","year":"1998","unstructured":"Stella L, de Novellis V, Marabese I, Berrino L, Maione S, Filippelli A, Rossi F (1998) The role of A3 adenosine receptors in central regulation of arterial blood pressure. Br J Pharmacol 125(3):437\u2013440","journal-title":"Br J Pharmacol"},{"issue":"2","key":"9_CR112_9","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/jn.1997.78.2.891","volume":"78","author":"E Tanaka","year":"1997","unstructured":"Tanaka E, Yamamoto S, Kudo Y, Mihara S, Higashi H (1997) Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro. J Neurophysiol 78(2):891\u2013902","journal-title":"J Neurophysiol"},{"issue":"3","key":"9_CR113_9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1172\/JCI8253","volume":"105","author":"SL Tilley","year":"2000","unstructured":"Tilley SL, Wagoner VA, Salvatore CA, Jacobson MA, Koller BH (2000) Adenosine and inosine increase cutaneous vasopermeability by activating A(3) receptors on mast cells. J Clin Invest 105(3):361\u2013367","journal-title":"J Clin Invest"},{"issue":"6","key":"9_CR114_9","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1124\/mol.62.6.1373","volume":"62","author":"ML Trincavelli","year":"2002","unstructured":"Trincavelli ML, Tuscano D, Marroni M, Falleni A, Gremigni V, Ceruti S, Abbracchio MP, Jacobson KA, Cattabeni F, Martini C (2002) A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. Mol Pharmacol 62(6):1373\u20131384","journal-title":"Mol Pharmacol"},{"issue":"5","key":"9_CR115_9","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/j.1471-4159.1979.tb05236.x","volume":"33","author":"D Calker van","year":"1979","unstructured":"van Calker D, Muller M, Hamprecht B (1979) Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem 33(5):999\u20131005","journal-title":"J Neurochem"},{"issue":"Suppl 5","key":"9_CR116_9","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1528-1167.2005.01027.x","volume":"46","author":"EP Vianna","year":"2005","unstructured":"Vianna EP, Ferreira AT, Dona F, Cavalheiro EA, Silva Fernandes MJ (2005) Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. Epilepsia 46(Suppl 5):166\u2013173","journal-title":"Epilepsia"},{"issue":"15","key":"9_CR117_9","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1021\/jm0109762","volume":"45","author":"R Volpini","year":"2002","unstructured":"Volpini R, Costanzi S, Lambertucci C, Taffi S, Vittori S, Klotz KN, Cristalli G (2002) N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem 45(15):3271\u20133279","journal-title":"J Med Chem"},{"issue":"6","key":"9_CR118_9","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1021\/jm060963u","volume":"50","author":"R Volpini","year":"2007","unstructured":"Volpini R, Dal Ben D, Lambertucci C, Taffi S, Vittori S, Klotz KN, Cristalli G (2007) N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem 50(6):1222\u20131230","journal-title":"J Med Chem"},{"issue":"6","key":"9_CR119_9","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1097\/00001756-200004270-00016","volume":"11","author":"CA Arnim von","year":"2000","unstructured":"von Arnim CA, Timmler M, Ludolph AC, Riepe MW (2000) Adenosine receptor up-regulation: initiated upon preconditioning but not upheld. Neuroreport 11(6):1223\u20131226","journal-title":"Neuroreport"},{"issue":"39","key":"9_CR120_9","doi-asserted-by":"publisher","first-page":"9913","DOI":"10.1523\/JNEUROSCI.2290-06.2006","volume":"26","author":"CA Arnim von","year":"2006","unstructured":"von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT (2006) GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J Neurosci 26(39):9913\u20139922","journal-title":"J Neurosci"},{"issue":"1","key":"9_CR121_9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0014-2999(99)00135-1","volume":"371","author":"DK Lubitz von","year":"1999","unstructured":"von Lubitz DK (1999) Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? Eur J Pharmacol 371(1):85\u2013102","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"9_CR122_9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0014-2999(94)90523-1","volume":"263","author":"DK Lubitz von","year":"1994","unstructured":"von Lubitz DK, Lin RC, Popik P, Carter MF, Jacobson KA (1994) Adenosine A3 receptor stimulation and cerebral ischemia. Eur J Pharmacol 263(1\u20132):59\u201367","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"9_CR123_9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0014-2999(94)00734-O","volume":"275","author":"DK Lubitz von","year":"1995","unstructured":"von Lubitz DK, Carter MF, Deutsch SI, Lin RC, Mastropaolo J, Meshulam Y, Jacobson KA (1995) The effects of adenosine A3 receptor stimulation on seizures in mice. Eur J Pharmacol 275(1):23\u201329","journal-title":"Eur J Pharmacol"},{"key":"9_CR124_9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1749-6632.1999.tb07984.x","volume":"890","author":"DK Lubitz von","year":"1999","unstructured":"von Lubitz DK, Ye W, McClellan J, Lin RC (1999) Stimulation of adenosine A3 receptors in cerebral ischemia. Neuronal death, recovery, or both? Ann N Y Acad Sci 890:93\u2013106","journal-title":"Ann N Y Acad Sci"},{"key":"9_CR125_9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1749-6632.2001.tb03615.x","volume":"939","author":"DK Lubitz von","year":"2001","unstructured":"von Lubitz DK, Simpson KL, Lin RC (2001) Right thing at a wrong time? Adenosine A3 receptors and cerebroprotection in stroke. Ann N Y Acad Sci 939:85\u201396","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"9_CR126_9","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/glia.20016","volume":"46","author":"MC Wittendorp","year":"2004","unstructured":"Wittendorp MC, Boddeke HW, Biber K (2004) Adenosine A3 receptor-induced CCL2 synthesis in cultured mouse astrocytes. Glia 46(4):410\u2013418","journal-title":"Glia"},{"issue":"3","key":"9_CR127_9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S0306-4522(02)00273-7","volume":"114","author":"WP Wu","year":"2002","unstructured":"Wu WP, Hao JX, Halldner-Henriksson L, Xu XJ, Jacobson MA, Wiesenfeld-Hallin Z, Fredholm BB (2002) Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors. Neuroscience 114(3):523\u2013527","journal-title":"Neuroscience"},{"issue":"3","key":"9_CR128_9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0014-5793(02)03612-8","volume":"532","author":"R Yaar","year":"2002","unstructured":"Yaar R, Lamperti ED, Toselli PA, Ravid K (2002) Activity of the A3 adenosine receptor gene promoter in transgenic mice: characterization of previously unidentified sites of expression. FEBS Lett 532(3):267\u2013272","journal-title":"FEBS Lett"},{"issue":"2","key":"9_CR129_9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1006\/bbrc.1997.6290","volume":"232","author":"Y Yao","year":"1997","unstructured":"Yao Y, Sei Y, Abbracchio MP, Jiang JL, Kim YC, Jacobson KA (1997) Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists. Biochem Biophys Res Commun 232(2):317\u2013322","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"9_CR130_9","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1213\/01.ANE.0000180994.10087.6F","volume":"101","author":"MH Yoon","year":"2005","unstructured":"Yoon MH, Bae HB, Choi JI (2005) Antinociception of intrathecal adenosine receptor subtype agonists in rat formalin test. Anesth Analg 101(5):1417\u20131421","journal-title":"Anesth Analg"},{"issue":"1","key":"9_CR131_9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1159\/000094762","volume":"78","author":"MH Yoon","year":"2006","unstructured":"Yoon MH, Bae HB, Choi JI, Kim SJ, Chung ST, Kim CM (2006) Roles of adenosine receptor subtypes in the antinociceptive effect of intrathecal adenosine in a rat formalin test. Pharmacology 78(1):21\u201326","journal-title":"Pharmacology"},{"issue":"1","key":"9_CR132_9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1006\/geno.1998.5696","volume":"57","author":"Z Zhao","year":"1999","unstructured":"Zhao Z, Francis C, Ravid K (1999) Characterization of the mouse A3 adenosine receptor gene: exon\/intron organization and promoter activity. Genomics 57(1):152\u2013155","journal-title":"Genomics"},{"issue":"1","key":"9_CR133_9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4049\/jimmunol.171.1.338","volume":"171","author":"H Zhong","year":"2003","unstructured":"Zhong H, Shlykov SG, Molina JG, Sanborn BM, Jacobson MA, Tilley SL, Blackburn MR (2003) Activation of murine lung mast cells by the adenosine A3 receptor. J Immunol 171(1):338\u2013345","journal-title":"J Immunol"},{"issue":"16","key":"9_CR134_9","doi-asserted-by":"publisher","first-page":"7432","DOI":"10.1073\/pnas.89.16.7432","volume":"89","author":"QY Zhou","year":"1992","unstructured":"Zhou QY, Li C, Olah ME, Johnson RA, Stiles GL, Civelli O (1992) Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc Natl Acad Sci U S A 89(16):7432\u20137436","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9_CR135_9","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1124\/mol.65.6.1462","volume":"65","author":"CB Zhu","year":"2004","unstructured":"Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD (2004) Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol Pharmacol 65(6):1462\u20131474","journal-title":"Mol Pharmacol"},{"issue":"1","key":"9_CR136_9","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1124\/jpet.107.121665","volume":"322","author":"CB Zhu","year":"2007","unstructured":"Zhu CB, Steiner JA, Munn JL, Daws LC, Hewlett WA, Blakely RD (2007) Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. J Pharmacol Exp Ther 322(1):332\u2013340","journal-title":"J Pharmacol Exp Ther"}],"container-title":["A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-90-481-3144-0_9.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T14:31:07Z","timestamp":1739457067000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-90-481-3144-0_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,6]]},"ISBN":["9789048131433","9789048131440"],"references-count":136,"URL":"https:\/\/doi.org\/10.1007\/978-90-481-3144-0_9","relation":{},"subject":[],"published":{"date-parts":[[2009,11,6]]}}}