{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:15:07Z","timestamp":1761218107169,"version":"3.44.0"},"publisher-location":"Singapore","reference-count":126,"publisher":"Springer Nature Singapore","isbn-type":[{"type":"print","value":"9789811309465"},{"type":"electronic","value":"9789811309472"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-981-13-0947-2_8","type":"book-chapter","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T09:25:40Z","timestamp":1540373140000},"page":"127-146","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Natural-Based Biomaterials in Advanced Therapies for Autoimmune Diseases"],"prefix":"10.1007","author":[{"given":"Helena","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Joana F.","family":"Fangueiro","sequence":"additional","affiliation":[]},{"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"issue":"2","key":"8_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1089\/humc.2013.119","volume":"24","author":"A Aiuti","year":"2013","unstructured":"Aiuti A, Cossu G, de Felipe P, Galli MC, Narayanan G, Renner M, Voltz-Girolt C (2013) The committee for advanced therapies\u2019 of the European Medicines Agency reflection paper on management of clinical risks deriving from insertional mutagenesis. Hum Gene Ther Clin Dev 24(2):47\u201354. https:\/\/doi.org\/10.1089\/humc.2013.119","journal-title":"Hum Gene Ther Clin Dev"},{"issue":"18","key":"8_CR2","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.2174\/1381612821666150316123711","volume":"21","author":"M Anna-Maria","year":"2015","unstructured":"Anna-Maria M, Andrea F, Hugo AK, Ziya K (2015) Mouse models of autoimmune diseases -autoimmune myocarditis. Curr Pharm Des 21(18):2498\u20132512. https:\/\/doi.org\/10.2174\/1381612821666150316123711","journal-title":"Curr Pharm Des"},{"key":"8_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/B978-0-12-396983-5.00004-1","volume-title":"Chapter 4: Natural polymers: polysaccharides and their derivatives for biomedical applications natural and synthetic biomedical polymers","author":"A Aravamudhan","year":"2014","unstructured":"Aravamudhan A, Ramos DM, Nada AA, Kumbar SG (2014) Chapter 4: Natural polymers: polysaccharides and their derivatives for biomedical applications natural and synthetic biomedical polymers. Elsevier, Oxford, pp 67\u201389. https:\/\/doi.org\/10.1016\/B978-0-12-396983-5.00004-1"},{"issue":"10044","key":"8_CR4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/s0140-6736(16)30169-6","volume":"388","author":"HL Atkins","year":"2016","unstructured":"Atkins HL, Bowman M, Allan D, Anstee G, Arnold DL, Bar-Or A, Freedman MS (2016) Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. Lancet 388(10044):576\u2013585. https:\/\/doi.org\/10.1016\/s0140-6736(16)30169-6","journal-title":"Lancet"},{"key":"8_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.intimp.2017.03.016","volume":"47","author":"R Baharlou","year":"2017","unstructured":"Baharlou R, Ahmadi-Vasmehjani A, Faraji F, Atashzar MR, Khoubyari M, Ahi S, Navabi SS (2017) Human adipose tissue-derived mesenchymal stem cells in rheumatoid arthritis: regulatory effects on peripheral blood mononuclear cells activation. Int Immunopharmacol 47:59\u201369. https:\/\/doi.org\/10.1016\/j.intimp.2017.03.016","journal-title":"Int Immunopharmacol"},{"key":"8_CR6","doi-asserted-by":"publisher","first-page":"Ch. 02","DOI":"10.5772\/64301","volume-title":"Emerging concepts in analysis and applications of hydrogels","author":"M Bahram","year":"2016","unstructured":"Bahram M, Mohseni N, Moghtader M (2016) An introduction to hydrogels and some recent applications. In: Majee SB (ed) Emerging concepts in analysis and applications of hydrogels. InTech, Rijeka, p Ch. 02. https:\/\/doi.org\/10.5772\/64301"},{"issue":"1","key":"8_CR7","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1038\/s41598-017-04559-y","volume":"7","author":"L Bai","year":"2017","unstructured":"Bai L, Shao H, Wang H, Zhang Z, Su C, Dong L, Zhang X (2017) Effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis. Sci Rep 7(1):4323. https:\/\/doi.org\/10.1038\/s41598-017-04559-y","journal-title":"Sci Rep"},{"issue":"10","key":"8_CR8","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.2337\/db11-0844","volume":"61","author":"\u00caJ Bassi","year":"2012","unstructured":"Bassi \u00caJ, Moraes-Vieira PMM, Moreira-S\u00e1 CSR, Almeida DC, Vieira LM, Cunha CS, C\u00e2mara NOS (2012) Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes. Diabetes 61(10):2534\u20132545. https:\/\/doi.org\/10.2337\/db11-0844","journal-title":"Diabetes"},{"key":"8_CR9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jconrel.2015.07.030","volume":"219","author":"EV Batrakova","year":"2015","unstructured":"Batrakova EV, Kim MS (2015) Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release 219:396\u2013405. https:\/\/doi.org\/10.1016\/j.jconrel.2015.07.030","journal-title":"J Control Release"},{"key":"8_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41129-3","volume-title":"Natural polymer drug delivery systems","author":"S Bhatia","year":"2016","unstructured":"Bhatia S (2016) Natural polymers vs synthetic polymer. In: Springer C (ed) Natural polymer drug delivery systems. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-41129-3"},{"issue":"7","key":"8_CR11","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1021\/la9011718","volume":"26","author":"S Bhattacharya","year":"2010","unstructured":"Bhattacharya S, Biswas J (2010) Understanding membranes through the molecular design of lipids. Langmuir 26(7):4642\u20134654. https:\/\/doi.org\/10.1021\/la9011718","journal-title":"Langmuir"},{"issue":"3","key":"8_CR12","first-page":"365","volume":"3","author":"Z Blach-Olszewska","year":"2007","unstructured":"Blach-Olszewska Z, Leszek J (2007) Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders. Neuropsychiatr Dis Treat 3(3):365\u2013372 ISSN: 1176-6328","journal-title":"Neuropsychiatr Dis Treat"},{"key":"8_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.coviro.2016.08.004","volume":"21","author":"D Blessing","year":"2016","unstructured":"Blessing D, D\u00e9glon N (2016) Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system. Curr Opin Virol 21:61\u201366. https:\/\/doi.org\/10.1016\/j.coviro.2016.08.004","journal-title":"Curr Opin Virol"},{"issue":"3","key":"8_CR14","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s13346-015-0220-8","volume":"5","author":"M-L Briuglia","year":"2015","unstructured":"Briuglia M-L, Rotella C, McFarlane A, Lamprou DA (2015) Influence of cholesterol on liposome stability and on in vitro drug release. Drug Deliv Transl Res 5(3):231\u2013242. https:\/\/doi.org\/10.1007\/s13346-015-0220-8","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"8_CR15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10072-010-0382-6","volume":"31","author":"V Bruno","year":"2011","unstructured":"Bruno V, Battaglia G, Nicoletti F (2011) The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases. Neurol Sci 31(3):283\u2013288. https:\/\/doi.org\/10.1007\/s10072-010-0382-6","journal-title":"Neurol Sci"},{"issue":"4","key":"8_CR16","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.yjmcc.2005.01.009","volume":"38","author":"G Cai","year":"2005","unstructured":"Cai G, Zhang J, Liu L, Shen Q (2005) Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense CIITA. J Mol Cell Cardiol 38(4):593\u2013605. https:\/\/doi.org\/10.1016\/j.yjmcc.2005.01.009","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"8_CR17","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/cr.2011.196","volume":"22","author":"Z Cai","year":"2012","unstructured":"Cai Z, Zhang W, Yang F, Yu L, Yu Z, Pan J, Wang J (2012) Immunosuppressive exosomes from TGF-\u03b21 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells. Cell Res 22(3):607\u2013610. https:\/\/doi.org\/10.1038\/cr.2011.196","journal-title":"Cell Res"},{"key":"8_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-1-60761-984-0_2","volume":"695","author":"E Carletti","year":"2011","unstructured":"Carletti E, Motta A, Migliaresi C (2011) Scaffolds for tissue engineering and 3D cell culture. Methods Mol Biol 695:17\u201339. https:\/\/doi.org\/10.1007\/978-1-60761-984-0_2","journal-title":"Methods Mol Biol"},{"issue":"Suppl 4","key":"8_CR19","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00586-008-0745-3","volume":"17","author":"BP Chan","year":"2008","unstructured":"Chan BP, Leong KW (2008) Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J 17(Suppl 4):467\u2013479. https:\/\/doi.org\/10.1007\/s00586-008-0745-3","journal-title":"Eur Spine J"},{"issue":"1","key":"8_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","volume":"20","author":"A Charles","year":"2002","unstructured":"Charles A, Janeway J, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20(1):197\u2013216. https:\/\/doi.org\/10.1146\/annurev.immunol.20.083001.084359","journal-title":"Annu Rev Immunol"},{"key":"8_CR21","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm.3897","volume":"21","author":"JH Cho","year":"2015","unstructured":"Cho JH, Feldman M (2015) Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies. Nat Med 21:730. https:\/\/doi.org\/10.1038\/nm.3897","journal-title":"Nat Med"},{"issue":"4","key":"8_CR22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2174\/156652307781369119","volume":"7","author":"C Claudius","year":"2007","unstructured":"Claudius C, Rashmi G, Hema M, Hanno N, Christiane JB, Reinhard K, Peter JN (2007) Genetically engineered stem cells for therapeutic gene delivery. Curr Gene Ther 7(4):249\u2013260. https:\/\/doi.org\/10.2174\/156652307781369119","journal-title":"Curr Gene Ther"},{"key":"8_CR23","unstructured":"Clinical Trials Gov (2017) https:\/\/clinicaltrials.gov\/. Accessed in 23\/01\/2018."},{"issue":"7","key":"8_CR24","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.autrev.2017.05.002","volume":"16","author":"N Coronel-Restrepo","year":"2017","unstructured":"Coronel-Restrepo N, Posso-Osorio I, Naranjo-Escobar J, Tob\u00f3n GJ (2017) Autoimmune diseases and their relation with immunological, neurological and endocrinological axes. Autoimm Rev 16(7):684\u2013692. https:\/\/doi.org\/10.1016\/j.autrev.2017.05.002","journal-title":"Autoimm Rev"},{"issue":"3","key":"8_CR25","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/art.30174","volume":"63","author":"G Courties","year":"2011","unstructured":"Courties G, Baron M, Presumey J, Escriou V, van Lent P, Scherman D, Davignon JL (2011) Cytosolic phospholipase A2alpha gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis. Arthritis Rheum 63(3):681\u2013690. https:\/\/doi.org\/10.1002\/art.30174","journal-title":"Arthritis Rheum"},{"issue":"1","key":"8_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1089\/hum.2013.2527","volume":"25","author":"RG Crystal","year":"2014","unstructured":"Crystal RG (2014) Adenovirus: the first effective in vivo gene delivery vector. Hum Gene Ther 25(1):3\u201311. https:\/\/doi.org\/10.1089\/hum.2013.2527","journal-title":"Hum Gene Ther"},{"key":"8_CR27","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.carbpol.2017.10.021","volume":"180","author":"TL Cupino","year":"2018","unstructured":"Cupino TL, Watson BA, Cupino AC, Oda K, Ghamsary MG, Soriano S, Kirsch WM (2018) Stability and bioactivity of chitosan as a transfection agent in primary human cell cultures: a case for chitosan-only controls. Carbohydr Polym 180:376\u2013384. https:\/\/doi.org\/10.1016\/j.carbpol.2017.10.021","journal-title":"Carbohydr Polym"},{"issue":"4","key":"8_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.addr.2006.03.001","volume":"58","author":"JM Dang","year":"2006","unstructured":"Dang JM, Leong KW (2006) Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 58(4):487\u2013499. https:\/\/doi.org\/10.1016\/j.addr.2006.03.001","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"8_CR29","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jconrel.2006.04.009","volume":"113","author":"CR Dass","year":"2006","unstructured":"Dass CR, Choong PF (2006) Selective gene delivery for cancer therapy using cationic liposomes: in vivo proof of applicability. J Control Release 113(2):155\u2013163. https:\/\/doi.org\/10.1016\/j.jconrel.2006.04.009","journal-title":"J Control Release"},{"key":"8_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.addr.2013.11.005","volume":"67-68","author":"P de Vos","year":"2014","unstructured":"de Vos P, Lazarjani HA, Poncelet D, Faas MM (2014) Polymers in cell encapsulation from an enveloped cell perspective. Adv Drug Deliv Rev 67-68:15\u201334. https:\/\/doi.org\/10.1016\/j.addr.2013.11.005","journal-title":"Adv Drug Deliv Rev"},{"key":"8_CR31","unstructured":"EMA, European Medicinal Agency (2017) Summaries of scientific recommendations on classification of advanced therapy medicinal products"},{"key":"8_CR32","doi-asserted-by":"publisher","unstructured":"Enderami SE, Soleimani M, Mortazavi Y, Nadri S, Salimi A (2017) Generation of insulin-producing cells from human adipose-derived mesenchymal stem cells on PVA scaffold by optimized differentiation protocol. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.26266","DOI":"10.1002\/jcp.26266"},{"key":"8_CR33","unstructured":"European Commission (2009) Commission Directive 2009\/120\/EC of 14 September 2009 amending Directive 2001\/83\/EC of the European Parliament and of the Council on the Community code relating to medicinal products for human use as regards advanced therapy medicinal products. Off J Eur Union"},{"issue":"11","key":"8_CR34","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.bbalip.2011.06.009","volume":"1811","author":"E Fahy","year":"2011","unstructured":"Fahy E, Cotter D, Sud M, Subramaniam S (2011) Lipid classification, structures and tools. Biochim Biophys Acta 1811(11):637\u2013647. https:\/\/doi.org\/10.1016\/j.bbalip.2011.06.009","journal-title":"Biochim Biophys Acta"},{"issue":"21","key":"8_CR35","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.1073\/pnas.84.21.7413","volume":"84","author":"PL Felgner","year":"1987","unstructured":"Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, Danielsen M (1987) Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84(21):7413\u20137417 ISSN: 0027-8424","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"8_CR36","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s00216-005-3251-z","volume":"382","author":"H Ferreira","year":"2005","unstructured":"Ferreira H, Lucio M, Lima JL, Matos C, Reis S (2005a) Effects of diclofenac on EPC liposome membrane properties. Anal Bioanal Chem 382(5):1256\u20131264. https:\/\/doi.org\/10.1007\/s00216-005-3251-z","journal-title":"Anal Bioanal Chem"},{"issue":"6","key":"8_CR37","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1002\/jps.20351","volume":"94","author":"H Ferreira","year":"2005","unstructured":"Ferreira H, Lucio M, Lima JL, Matos C, Reis S (2005b) Interaction of clonixin with EPC liposomes used as membrane models. J Pharm Sci 94(6):1277\u20131287. https:\/\/doi.org\/10.1002\/jps.20351","journal-title":"J Pharm Sci"},{"issue":"23","key":"8_CR38","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1182\/blood-2012-06-440123","volume":"120","author":"JD Finn","year":"2012","unstructured":"Finn JD, Nichols TC, Svoronos N, Merricks EP, Bellenger DA, Zhou S, Arruda VR (2012) The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy. Blood 120(23):4521\u20134523. https:\/\/doi.org\/10.1182\/blood-2012-06-440123","journal-title":"Blood"},{"issue":"3","key":"8_CR39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/intimm\/dxn147","volume":"21","author":"BB Ganesh","year":"2009","unstructured":"Ganesh BB, Cheatem DM, Sheng JR, Vasu C, Prabhakar BS (2009) GM-CSF-induced CD11c+CD8a\u2014dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int Immun 21(3):269\u2013282. https:\/\/doi.org\/10.1093\/intimm\/dxn147","journal-title":"Int Immun"},{"issue":"2","key":"8_CR40","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.drudis.2016.10.014","volume":"22","author":"A Ganju","year":"2017","unstructured":"Ganju A, Khan S, Hafeez BB, Behrman SW, Yallapu MM, Chauhan SC, Jaggi M (2017) miRNA nanotherapeutics for cancer. Drug Discov Today 22(2):424\u2013432. https:\/\/doi.org\/10.1016\/j.drudis.2016.10.014","journal-title":"Drug Discov Today"},{"issue":"2","key":"8_CR41","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12016-011-8283-x","volume":"41","author":"ME Gershwin","year":"2011","unstructured":"Gershwin ME, Shoenfeld Y (2011) Cutting-edge issues in organ-specific autoimmunity. Clin Rev Allergy Immunol 41(2):123\u2013125. https:\/\/doi.org\/10.1007\/s12016-011-8283-x","journal-title":"Clin Rev Allergy Immunol"},{"key":"8_CR42","doi-asserted-by":"publisher","unstructured":"Gianchecchi E, Delfino DV, Fierabracci A (2017) NK cells in autoimmune diseases: linking innate and adaptive immune responses. Autoimmu Rev. https:\/\/doi.org\/10.1016\/j.autrev.2017.11.018","DOI":"10.1016\/j.autrev.2017.11.018"},{"issue":"8","key":"8_CR43","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1016\/j.nano.2017.08.005","volume":"13","author":"AG Grigoras","year":"2017","unstructured":"Grigoras AG (2017) Polymer-lipid hybrid systems used as carriers for insulin delivery. Nanomedicine 13(8):2425\u20132437. https:\/\/doi.org\/10.1016\/j.nano.2017.08.005","journal-title":"Nanomedicine"},{"issue":"3","key":"8_CR44","first-page":"255","volume":"16","author":"S Hajizadeh-Sikaroodi","year":"2014","unstructured":"Hajizadeh-Sikaroodi S, Hosseini A, Fallah A, Estiri H, Noormohammadi Z, Salehi M, Kazemi B (2014) Lentiviral mediating genetic engineered mesenchymal stem cells for releasing IL-27 as a gene therapy approach for autoimmune diseases. Cell J (Yakhteh) 16(3):255\u2013262 ISSN: 2228-5806","journal-title":"Cell J (Yakhteh)"},{"key":"8_CR45","doi-asserted-by":"publisher","unstructured":"Hanna E, R\u00e9muzat C, Auquier P, Toumi M (2016) Advanced therapy medicinal products: current and future perspectives. J Mark Access Health Pol 4. https:\/\/doi.org\/10.3402\/jmahp.v4.31036","DOI":"10.3402\/jmahp.v4.31036"},{"key":"8_CR46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jaut.2013.05.001","volume":"44","author":"E Hintermann","year":"2013","unstructured":"Hintermann E, Ehser J, Bayer M, Pfeilschifter JM, Christen U (2013) Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. J Autoimm 44:49\u201360. https:\/\/doi.org\/10.1016\/j.jaut.2013.05.001","journal-title":"J Autoimm"},{"issue":"2","key":"8_CR47","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2174\/1871530317666170424101256","volume":"17","author":"X Hou","year":"2017","unstructured":"Hou X, Zhou J, Yang R, Liu SS, Bi M, Liu T, Li YS (2017) Effect of halofuginone on the pathogenesis of autoimmune thyroid disease in different mice models. Endocr Metab Immune Disord Drug Targets 17(2):141\u2013148. https:\/\/doi.org\/10.2174\/1871530317666170424101256","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"8_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3402\/jev.v5.31027","volume":"5","author":"ME Hung","year":"2016","unstructured":"Hung ME, Leonard JN (2016) A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. J Extracell Vesicles 5:1\u201313. https:\/\/doi.org\/10.3402\/jev.v5.31027","journal-title":"J Extracell Vesicles"},{"key":"8_CR49","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3389\/fimmu.2016.00470","volume":"7","author":"MK Juric","year":"2016","unstructured":"Juric MK, Ghimire S, Ogonek J, Weissinger EM, Holler E, van Rood JJ, Greinix HT (2016) Milestones of hematopoietic stem cell transplantation\u00a0\u2013 from first human studies to current developments. Front Immunol 7:470. https:\/\/doi.org\/10.3389\/fimmu.2016.00470","journal-title":"Front Immunol"},{"issue":"3\u20134","key":"8_CR50","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1615\/ForumImmunDisTher.2016016491","volume":"6","author":"S Katsiougiannis","year":"2015","unstructured":"Katsiougiannis S (2015) Extracellular vesicles: evolving contributors in autoimmunity. Immunopathol Dis Therap 6(3\u20134):163\u2013170. https:\/\/doi.org\/10.1615\/ForumImmunDisTher.2016016491","journal-title":"Immunopathol Dis Therap"},{"issue":"2","key":"8_CR51","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.retram.2016.03.003","volume":"64","author":"PJ Kelsey","year":"2016","unstructured":"Kelsey PJ, Oliveira MC, Badoglio M, Sharrack B, Farge D, Snowden JA (2016) Haematopoietic stem cell transplantation in autoimmune diseases: from basic science to clinical practice. Curr Res Transl Med 64(2):71\u201382. https:\/\/doi.org\/10.1016\/j.retram.2016.03.003","journal-title":"Curr Res Transl Med"},{"issue":"3","key":"8_CR52","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00441-015-2140-9","volume":"361","author":"L Khorsandi","year":"2015","unstructured":"Khorsandi L, Khodadadi A, Nejad-Dehbashi F, Saremy S (2015) Three-dimensional differentiation of adipose-derived mesenchymal stem cells into insulin-producing cells. Cell Tissue Res 361(3):745\u2013753. https:\/\/doi.org\/10.1007\/s00441-015-2140-9","journal-title":"Cell Tissue Res"},{"issue":"8","key":"8_CR53","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1002\/art.23660","volume":"58","author":"M Khoury","year":"2008","unstructured":"Khoury M, Escriou V, Courties G, Galy A, Yao R, Largeau C, Apparailly F (2008) Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes. Arthritis Rheum 58(8):2356\u20132367. https:\/\/doi.org\/10.1002\/art.23660","journal-title":"Arthritis Rheum"},{"key":"8_CR54","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jconrel.2015.08.025","volume":"216","author":"MJ Kim","year":"2015","unstructured":"Kim MJ, Park J-S, Lee SJ, Jang J, Park JS, Back SH, Kim K (2015) Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy. J Control Release 216:140\u2013148. https:\/\/doi.org\/10.1016\/j.jconrel.2015.08.025","journal-title":"J Control Release"},{"issue":"4","key":"8_CR55","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.4049\/jimmunol.179.4.2242","volume":"179","author":"SH Kim","year":"2007","unstructured":"Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD (2007) Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol 179(4):2242\u20132249. https:\/\/doi.org\/10.4049\/jimmunol.179.4.2242","journal-title":"J Immunol"},{"key":"8_CR56","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.ijbiomac.2017.06.061","volume":"105","author":"F Kong","year":"2017","unstructured":"Kong F, Liu G, Zhou S, Guo J, Chen S, Wang Z (2017a) Superior transfection efficiency of phagocytic astrocytes by large chitosan\/DNA nanoparticles. Int J Biol Macromol 105:1473\u20131481. https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.06.061","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"8_CR57","first-page":"6198","volume":"10","author":"Y Kong","year":"2017","unstructured":"Kong Y, Wang J, Shen LJ, Zhu YQ, Shen H, Shi Q, Huang L (2017b) B7-2 gene silencing by lentivirus-mediated delivery of shRNA reduces progression of experimental lupus nephritis. Int J Clin Exp Pathol 10(6):6198\u20136209 ISSN:1936\u20132625","journal-title":"Int J Clin Exp Pathol"},{"issue":"3","key":"8_CR58","first-page":"76","volume":"8","author":"A Kotsiafti","year":"2017","unstructured":"Kotsiafti A, Eleutheriou D, Stabouli S (2017) Atherosclerosis as an autoimmune disease. Hell J Atheroscler 8(3):76\u201385","journal-title":"Hell J Atheroscler"},{"key":"8_CR59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev-bioeng-071813-104938","volume":"17","author":"MA Kotterman","year":"2015","unstructured":"Kotterman MA, Chalberg TW, Schaffer DV (2015) Viral vectors for gene therapy: translational and clinical outlook. Annu Rev Biomed Eng 17:63\u201389. https:\/\/doi.org\/10.1146\/annurev-bioeng-071813-104938","journal-title":"Annu Rev Biomed Eng"},{"issue":"14","key":"8_CR60","doi-asserted-by":"publisher","first-page":"8481","DOI":"10.1074\/jbc.271.14.8481","volume":"271","author":"RJ Lee","year":"1996","unstructured":"Lee RJ, Huang L (1996) Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem 271(14):8481\u20138487. https:\/\/doi.org\/10.1074\/jbc.271.14.8481","journal-title":"J Biol Chem"},{"issue":"2","key":"8_CR61","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/mt.2013.245","volume":"22","author":"SJ Lee","year":"2014","unstructured":"Lee SJ, Lee A, Hwang SR, Park J-S, Jang J, Huh MS, Kim K (2014) TNF-\u03b1 gene silencing using polymerized siRNA\/Thiolated glycol chitosan nanoparticles for rheumatoid arthritis. Mol Ther 22(2):397\u2013408. https:\/\/doi.org\/10.1038\/mt.2013.245","journal-title":"Mol Ther"},{"issue":"4","key":"8_CR62","doi-asserted-by":"publisher","first-page":"151","DOI":"10.12691\/ijcd-3-4-8","volume":"3","author":"A Lerner","year":"2015","unstructured":"Lerner A, Jeremias P, Matthias T (2015) The world incidence and prevalence of autoimmune diseases is increasing. Int J Celiac Dis 3(4):151\u2013155. https:\/\/doi.org\/10.12691\/ijcd-3-4-8","journal-title":"Int J Celiac Dis"},{"key":"8_CR63","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/nbt.1989","volume":"29","author":"F Leuschner","year":"2011","unstructured":"Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Nahrendorf M (2011) Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29:1005. https:\/\/doi.org\/10.1038\/nbt.1989","journal-title":"Nat Biotechnol"},{"issue":"1","key":"8_CR64","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13287-015-0066-5","volume":"6","author":"C-y Li","year":"2015","unstructured":"Li C-y, Wu X-y, Tong J-b, Yang X-x, Zhao J-l, Zheng Q-f, Ma Z-j (2015) Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther 6(1):55. https:\/\/doi.org\/10.1186\/s13287-015-0066-5","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"8_CR65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/jcp.20897","volume":"211","author":"Y Li","year":"2007","unstructured":"Li Y, Zhang R, Qiao H, Zhang H, Wang Y, Yuan H, Pei X (2007) Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J Cell Physiol 211(1):36\u201344. https:\/\/doi.org\/10.1002\/jcp.20897","journal-title":"J Cell Physiol"},{"issue":"10","key":"8_CR66","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1089\/scd.2009.0010","volume":"18","author":"G Lin","year":"2009","unstructured":"Lin G, Wang G, Liu G, Yang L-J, Chang L-J, Lue TF, Lin C-S (2009) Treatment of type 1 diabetes with adipose tissue\u2013derived stem cells expressing pancreatic duodenal Homeobox 1. Stem Cells Dev 18(10):1399\u20131406. https:\/\/doi.org\/10.1089\/scd.2009.0010","journal-title":"Stem Cells Dev"},{"issue":"21","key":"8_CR67","doi-asserted-by":"publisher","first-page":"11840","DOI":"10.1128\/jvi.01253-07","volume":"81","author":"J Lin","year":"2007","unstructured":"Lin J, Zhi Y, Mays L, Wilson JM (2007) Vaccines based on novel adeno-associated virus vectors elicit aberrant CD8+ T-cell responses in mice. J Virol 81(21):11840\u201311849. https:\/\/doi.org\/10.1128\/jvi.01253-07","journal-title":"J Virol"},{"issue":"3","key":"8_CR68","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.bbrc.2017.08.075","volume":"492","author":"L Liu","year":"2017","unstructured":"Liu L, Liu Y, Yuan M, Xu L, Sun H (2017a) Elevated expression of microRNA-873 facilitates Th17 differentiation by targeting forkhead box O1 (Foxo1) in the pathogenesis of systemic lupus erythematosus. Biochem Biophys Res Commun 492(3):453\u2013460. https:\/\/doi.org\/10.1016\/j.bbrc.2017.08.075","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"8_CR69","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jphs.2017.02.001","volume":"133","author":"S Liu","year":"2017","unstructured":"Liu S, Kiyoi T, Takemasa E, Maeyama K (2017b) Intra-articular lentivirus-mediated gene therapy targeting CRACM1 for the treatment of collagen-induced arthritis. J Pharmacol Sci 133(3):130\u2013138. https:\/\/doi.org\/10.1016\/j.jphs.2017.02.001","journal-title":"J Pharmacol Sci"},{"issue":"5","key":"8_CR70","doi-asserted-by":"publisher","first-page":"A259","DOI":"10.1016\/j.autrev.2009.12.002.","volume":"9","author":"A Lleo","year":"2010","unstructured":"Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME (2010) Definition of human autoimmunity\u00a0\u2013 autoantibodies versus autoimmune disease. Autoimmunol Rev 9(5):A259\u2013A266. https:\/\/doi.org\/10.1016\/j.autrev.2009.12.002.","journal-title":"Autoimmunol Rev"},{"issue":"4","key":"8_CR71","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5301\/ijao.5000555","volume":"40","author":"R Long","year":"2017","unstructured":"Long R, Liu Y, Wang S, Ye L, He P (2017) Co-microencapsulation of BMSCs and mouse pancreatic \u03b2 cells for improving the efficacy of type I diabetes therapy. Int J Artif Organs 40(4):169\u2013175. https:\/\/doi.org\/10.5301\/ijao.5000555","journal-title":"Int J Artif Organs"},{"key":"8_CR72","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13287-017-0593-3","volume":"8","author":"X Lu","year":"2017","unstructured":"Lu X, Wang X, Nian H, Yang D, Wei R (2017) Mesenchymal stem cells for treating autoimmune dacryoadenitis. Stem Cell Res Ther 8:126. https:\/\/doi.org\/10.1186\/s13287-017-0593-3","journal-title":"Stem Cell Res Ther"},{"key":"8_CR73","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.coi.2015.09.001","volume":"37","author":"CL Lucas","year":"2015","unstructured":"Lucas CL, Lenardo MJ (2015) Identifying genetic determinants of autoimmunity and immune dysregulation. Curr Opin Immunol 37:28\u201333. https:\/\/doi.org\/10.1016\/j.coi.2015.09.001","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"8_CR74","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jneuroim.2009.02.017","volume":"210","author":"TK Makar","year":"2009","unstructured":"Makar TK, Bever CT, Singh IS, Royal W, Sahu SN, Sura TP, Trisler D (2009) Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle. J Neuroimmunol 210(1):40\u201351. https:\/\/doi.org\/10.1016\/j.jneuroim.2009.02.017","journal-title":"J Neuroimmunol"},{"issue":"3","key":"8_CR75","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s11095-011-0616-1","volume":"29","author":"R Mandke","year":"2012","unstructured":"Mandke R, Singh J (2012) Cationic nanomicelles for delivery of plasmids encoding Interleukin-4 and Interleukin-10 for prevention of autoimmune diabetes in mice. Pharm Res 29(3):883\u2013897. https:\/\/doi.org\/10.1007\/s11095-011-0616-1","journal-title":"Pharm Res"},{"issue":"17","key":"8_CR76","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1098\/rsif.2007.0220","volume":"4","author":"JF Mano","year":"2007","unstructured":"Mano JF, Silva GA, AzevedoHS MPB, Sousa RA, Silva S, Reis RL (2007) Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends. J R Soc Interface 4(17):999\u20131030. https:\/\/doi.org\/10.1098\/rsif.2007.0220","journal-title":"J R Soc Interface"},{"key":"8_CR77","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/9781119126218.ch31","volume-title":"Biomaterials from nature for advanced devices and therapies","author":"A Martins","year":"2016","unstructured":"Martins A, Ferreira H, Reis RL, Neves NM (2016a) Delivery systems made of natural-origin polymers for tissue engineering and regenerative medicine applications. In: Biomaterials from nature for advanced devices and therapies. Wiley, Hoboken, pp 581\u2013611. https:\/\/doi.org\/10.1002\/9781119126218.ch31"},{"issue":"3","key":"8_CR78","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.stemcr.2016.01.001","volume":"6","author":"M Martins","year":"2016","unstructured":"Martins M, Ribeiro D, Martins A, Reis RL, Neves NM (2016b) Extracellular vesicles derived from osteogenically induced human bone marrow mesenchymal stem cells can modulate lineage commitment. Stem Cell Rep 6(3):284\u2013291. https:\/\/doi.org\/10.1016\/j.stemcr.2016.01.001","journal-title":"Stem Cell Rep"},{"key":"8_CR79","unstructured":"Mascolo M, McNeill A, Fernandes M (2017) Autoimmune diseases\u00a0\u2013 modern diseases. Available at http:\/\/www.europarl.europa.eu\/supporting-analyses. Accessed Jan 2018"},{"issue":"6","key":"8_CR80","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1600-0897.2010.00822.x-","volume":"63","author":"L Mincheva-Nilsson","year":"2010","unstructured":"Mincheva-Nilsson L, Baranov V (2010) The role of placental exosomes in reproduction. Am J Reprod Immunol 63(6):520\u2013533. https:\/\/doi.org\/10.1111\/j.1600-0897.2010.00822.x-","journal-title":"Am J Reprod Immunol"},{"issue":"4","key":"8_CR81","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s13311-017-0545-8","volume":"14","author":"M Miralles","year":"2017","unstructured":"Miralles M, Eixarch H, Tejero M, Costa C, Hirota K, Castano AR, Chillon M (2017) Clinical and histopathological amelioration of experimental autoimmune encephalomyelitis by AAV vectors expressing a soluble interleukin-23 receptor. Neurotherapeutics 14(4):1095\u20131106. https:\/\/doi.org\/10.1007\/s13311-017-0545-8","journal-title":"Neurotherapeutics"},{"issue":"3","key":"8_CR82","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.stem.2008.02.005","volume":"2","author":"DJ Mooney","year":"2008","unstructured":"Mooney DJ, Vandenburgh H (2008) Cell delivery mechanisms for tissue repair. Cell Stem Cell 2(3):205\u2013213. https:\/\/doi.org\/10.1016\/j.stem.2008.02.005","journal-title":"Cell Stem Cell"},{"key":"8_CR83","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fbioe.2017.00055","volume":"5","author":"D Morrow","year":"2017","unstructured":"Morrow D, Ussi A, Migliaccio G (2017) Addressing pressing needs in the development of advanced therapies. Front Bioeng Biotechnol 5:55. https:\/\/doi.org\/10.3389\/fbioe.2017.00055","journal-title":"Front Bioeng Biotechnol"},{"issue":"9","key":"8_CR84","doi-asserted-by":"publisher","first-page":"E838","DOI":"10.1152\/ajpendo.00219.2014","volume":"307","author":"E Motte","year":"2014","unstructured":"Motte E, Szepessy E, Suenens K, Stange G, Bomans M, Jacobs-Tulleneers-Thevissen D, Pipeleers D (2014) Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell grafts. Am J Physiol Endocrinol Metab 307(9):E838\u2013E846. https:\/\/doi.org\/10.1152\/ajpendo.00219.2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"21","key":"8_CR85","doi-asserted-by":"publisher","first-page":"11382","DOI":"10.1073\/pnas.93.21.11382","volume":"93","author":"L Naldini","year":"1996","unstructured":"Naldini L, Bl\u00f6mer U, Gage FH, Trono D, Verma IM (1996) Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 93(21):11382\u201311388 ISSN: 0027\u20138424","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"8_CR86","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.3390\/polym6051312","volume":"6","author":"CN Ndidi","year":"2014","unstructured":"Ndidi CN, Nelson AO, Okezie IA (2014) Naturapolyceutics: the science of utilizing natural polymers for drug delivery. Polymers 6(5):1312\u20131332. https:\/\/doi.org\/10.3390\/polym6051312","journal-title":"Polymers"},{"issue":"1","key":"8_CR87","doi-asserted-by":"publisher","first-page":"64","DOI":"10.2174\/1566523214666141127095336","volume":"15","author":"O Negre","year":"2015","unstructured":"Negre O, Bartholomae C, Beuzard Y, Cavazzana M, Christiansen L, Courne C, Veres G (2015) Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of beta-thalassemia and sickle cell disease. Curr Gene Ther 15(1):64\u201381 ISSN: 1566-5232","journal-title":"Curr Gene Ther"},{"issue":"3","key":"8_CR88","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.yfrne.2014.04.004.","volume":"35","author":"ST Ngo","year":"2014","unstructured":"Ngo ST, Steyn FJ, McCombe PA (2014) Gender differences in autoimmune disease. Front Neuroendocrinol 35(3):347\u2013369. https:\/\/doi.org\/10.1016\/j.yfrne.2014.04.004.","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"8_CR89","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1369-7021(11)70058-X.","volume":"14","author":"FJ O\u2019Brien","year":"2011","unstructured":"O\u2019Brien FJ (2011) Biomaterials & scaffolds for tissue engineering. Mater Today 14(3):88\u201395. https:\/\/doi.org\/10.1016\/S1369-7021(11)70058-X.","journal-title":"Mater Today"},{"key":"8_CR90","doi-asserted-by":"publisher","unstructured":"Patel P, Chatterjee S (2018) Chapter 1: Innate and adaptive immunity: barriers and receptor-based recognition immunity and inflammation in health and disease. Academic Press, pp 3\u201313. https:\/\/doi.org\/10.1016\/B978-0-12-805417-8.00001-9","DOI":"10.1016\/B978-0-12-805417-8.00001-9"},{"key":"8_CR91","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/1479-5876-9-181","volume":"9","author":"JC Ra","year":"2011","unstructured":"Ra JC, Kang SK, Shin IS, Park HG, Joo SA, Kim JG, Kurtz A (2011) Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells. J Transl Med 9:181. https:\/\/doi.org\/10.1186\/1479-5876-9-181","journal-title":"J Transl Med"},{"key":"8_CR92","doi-asserted-by":"publisher","unstructured":"Raveendran S, Rochani AK, Maekawa T, Kumar DS (2017) Smart carriers and nanohealers: a nanomedical insight on natural polymers. Materials (Basel) 10(8). https:\/\/doi.org\/10.3390\/ma10080929","DOI":"10.3390\/ma10080929"},{"issue":"1","key":"8_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1087-0024.2004.00837.x","volume":"9","author":"NR Rose","year":"2004","unstructured":"Rose NR (2004) Autoimmune disease 2002: an overview. J Investig Dermatol Symp Proc 9(1):1\u20134. https:\/\/doi.org\/10.1111\/j.1087-0024.2004.00837.x","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"125","key":"8_CR94","doi-asserted-by":"publisher","first-page":"125sr121","DOI":"10.1126\/scitranslmed.3003504","volume":"4","author":"MD Rosenblum","year":"2012","unstructured":"Rosenblum MD, Gratz IK, Paw JS, Abbas AK (2012) Treating human autoimmunity: current practice and future prospects. Sci Transl Med 4(125):125sr121. https:\/\/doi.org\/10.1126\/scitranslmed.3003504","journal-title":"Sci Transl Med"},{"issue":"11\u201312","key":"8_CR95","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1111\/j.1582-4934.2009.00857.x","volume":"13","author":"NK Satija","year":"2009","unstructured":"Satija NK, Singh VK, Verma YK, Gupta P, Sharma S, Afrin F, Gurudutta GU (2009) Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine. J Cell Mol Med 13(11\u201312):4385\u20134402. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00857.x","journal-title":"J Cell Mol Med"},{"key":"8_CR96","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/B978-0-7020-5401-3.00018-7","volume-title":"18\u00a0\u2013 Autoimmune disease Scully\u2019s medical problems in dentistry","author":"C Scully","year":"2014","unstructured":"Scully C (2014) 18\u00a0\u2013 Autoimmune disease Scully\u2019s medical problems in dentistry, 7th edn. Churchill Livingstone, Oxford, pp 466\u2013480 ISBN: 978-0-7020-5401-3","edition":"7"},{"issue":"1","key":"8_CR97","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/bit.26461","volume":"115","author":"D Sharon","year":"2018","unstructured":"Sharon D, Kamen A (2018) Advancements in the design and scalable production of viral gene transfer vectors. Biotechnol Bioeng 115(1):25\u201340. https:\/\/doi.org\/10.1002\/bit.26461","journal-title":"Biotechnol Bioeng"},{"issue":"5","key":"8_CR98","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.stemcr.2017.04.008","volume":"8","author":"T Shigemoto-Kuroda","year":"2017","unstructured":"Shigemoto-Kuroda T, Oh JY, D-k K, Jeong HJ, Park SY, Lee HJ, Lee RH (2017) MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis. Stem Cell Rep 8(5):1214\u20131225. https:\/\/doi.org\/10.1016\/j.stemcr.2017.04.008","journal-title":"Stem Cell Rep"},{"issue":"2","key":"8_CR99","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12016-014-8451-x","volume":"49","author":"S-A Shu","year":"2015","unstructured":"Shu S-A, Wang J, Tao M-H, Leung PSC (2015) Gene therapy for autoimmune disease. Clin Rev Allergy Immunol 49(2):163\u2013176. https:\/\/doi.org\/10.1007\/s12016-014-8451-x","journal-title":"Clin Rev Allergy Immunol"},{"issue":"9","key":"8_CR100","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.progpolymsci.2011.05.003.","volume":"36","author":"A Sionkowska","year":"2011","unstructured":"Sionkowska A (2011) Current research on the blends of natural and synthetic polymers as new biomaterials: review. Prog Polym Sci 36(9):1254\u20131276. https:\/\/doi.org\/10.1016\/j.progpolymsci.2011.05.003.","journal-title":"Prog Polym Sci"},{"key":"8_CR101","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1742-4690-11-36","volume":"11","author":"M Sokol","year":"2014","unstructured":"Sokol M, Wabl M, Ruiz IR, Pedersen FS (2014) Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors. Retrovirology 11:36. https:\/\/doi.org\/10.1186\/1742-4690-11-36","journal-title":"Retrovirology"},{"issue":"1","key":"8_CR102","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13287-017-0627-x","volume":"8","author":"L Song","year":"2017","unstructured":"Song L, Sun Z, Kim DS, Gou W, Strange C, Dong H, Wang H (2017) Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function. Stem Cell Res Ther 8(1):192. https:\/\/doi.org\/10.1186\/s13287-017-0627-x","journal-title":"Stem Cell Res Ther"},{"key":"8_CR103","doi-asserted-by":"publisher","unstructured":"Stancu IC, Lungu A, Iovu H (2014) 3\u00a0\u2013 Hydrogels for bone regeneration biomaterials for bone regeneration (pp 62\u201386). Woodhead Publishing. https:\/\/doi.org\/10.1533\/9780857098104.1.62.","DOI":"10.1533\/9780857098104.1.62"},{"key":"8_CR104","doi-asserted-by":"publisher","first-page":"5302120","DOI":"10.1155\/2016\/5302120","volume":"6","author":"A Stepien","year":"2016","unstructured":"Stepien A, Dabrowska NL, Maciagowska M, Macoch RP, Zolocinska A, Mazur S, Pojda Z (2016) Clinical application of autologous adipose stem cells in patients with multiple sclerosis: preliminary results. Mediat Inflamm 6:5302120. https:\/\/doi.org\/10.1155\/2016\/5302120","journal-title":"Mediat Inflamm"},{"key":"8_CR105","series-title":"Current topics in microbiology and immunology","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-79496-4_2","volume-title":"The molecular repertoire of adenoviruses I","author":"PL Stewart","year":"1995","unstructured":"Stewart PL, Burnett RM (1995) Adenovirus structure by X-ray crystallography and electron microscopy. In: Doerfler W, B\u00f6hm P (eds) The molecular repertoire of adenoviruses I, Current topics in microbiology and immunology, vol 199\/1. Springer, Berlin\/Heidelberg. https:\/\/doi.org\/10.1007\/978-3-642-79496-4_2"},{"issue":"9","key":"8_CR106","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1038\/mt.2010.105.","volume":"18","author":"D Sun","year":"2010","unstructured":"Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, Zhang H-G (2010) A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther 18(9):1606\u20131614. https:\/\/doi.org\/10.1038\/mt.2010.105.","journal-title":"Mol Ther"},{"issue":"4","key":"8_CR107","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3892\/ijmm.2017.2914","volume":"39","author":"L-L Sun","year":"2017","unstructured":"Sun L-L, Liu T-J, Li L, Tang W, Zou J-J, Chen X-F, Shi Y-Q (2017) Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces \u03b2-cell proliferation in diabetic mice. Int J Mol Med 39(4):936\u2013948. https:\/\/doi.org\/10.3892\/ijmm.2017.2914","journal-title":"Int J Mol Med"},{"issue":"4 Suppl 92","key":"8_CR108","first-page":"S58","volume":"33","author":"Y Tanaka","year":"2015","unstructured":"Tanaka Y (2015) Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis. Clin Exp Rheumatol 33(4 Suppl 92):S58\u2013S62 ISSN: 0392-856X","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"8_CR109","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.3892\/mmr.2017.7111","volume":"16","author":"AP Tang","year":"2017","unstructured":"Tang AP, Li C, Chen ZH, Li T (2017) Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+\/CD8+ T cells and T-bet\/GATA-(3) expression in NOD mice. Mol Med Rep 16(4):3974\u20133982. https:\/\/doi.org\/10.3892\/mmr.2017.7111","journal-title":"Mol Med Rep"},{"key":"8_CR110","volume-title":"Polymers for controlled drug delivery","author":"PJ Tarcha","year":"1990","unstructured":"Tarcha PJ (1990) Polymers for controlled drug delivery. Taylor & Francis, London ISBN 9780849356520"},{"key":"8_CR111","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.carbpol.2016.11.067.","volume":"159","author":"FS Tekie","year":"2017","unstructured":"Tekie FS, Kiani M, Zakerian A, Pilevarian F, Assali A, Soleimani M, Atyabi F (2017) Nano polyelectrolyte complexes of carboxymethyl dextran and chitosan to improve chitosan-mediated delivery of miR-145. Carbohydr Polym 159:66\u201375. https:\/\/doi.org\/10.1016\/j.carbpol.2016.11.067.","journal-title":"Carbohydr Polym"},{"key":"8_CR112","doi-asserted-by":"publisher","unstructured":"Thery C, Amigorena S, Raposo G, Clayton A (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol, Chapter 3. Unit 3.22. https:\/\/doi.org\/10.1002\/0471143030.cb0322s30","DOI":"10.1002\/0471143030.cb0322s30"},{"issue":"3","key":"8_CR113","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1093\/jimmunol\/186.3.1313","volume":"186","author":"SL Tiegs","year":"2011","unstructured":"Tiegs SL, Russell DM, Nemazee D (2011) Receptor editing in self-reactive bone marrow B cells. J Immunol 186(3):1313\u20131324 ISSN: 0022-1767","journal-title":"J Immunol"},{"issue":"8","key":"8_CR114","doi-asserted-by":"publisher","first-page":"e42662","DOI":"10.1371\/journal.pone.0042662","volume":"7","author":"O Treacy","year":"2012","unstructured":"Treacy O, Ryan AE, Heinzl T, O\u2019Flynn L, Cregg M, Wilk M, Ritter T (2012) Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation. PLoS One 7(8):e42662. https:\/\/doi.org\/10.1371\/journal.pone.0042662","journal-title":"PLoS One"},{"issue":"9","key":"8_CR115","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.jcyt.2017.06.002","volume":"19","author":"F Urbinati","year":"2017","unstructured":"Urbinati F, Wherley J, Geiger S, Fernandez BC, Kaufman ML, Cooper A, Kohn DB (2017) Preclinical studies for a phase 1 clinical trial of autologous hematopoietic stem cell gene therapy for sickle cell disease. Cytotherapy 19(9):1096\u20131112. https:\/\/doi.org\/10.1016\/j.jcyt.2017.06.002","journal-title":"Cytotherapy"},{"key":"8_CR116","doi-asserted-by":"publisher","unstructured":"Velema J, Kaplan D (2006) Biopolymer-Based Biomaterials as Scaffolds for Tissue Engineering. In: Lee K, Kaplan D (eds) Tissue engineering I. Springer, Berlin\/Heidelberg, pp 187\u2013238. Adv Biochem Engin\/Biotechnol 102: 187\u2013238. https:\/\/doi.org\/10.1007\/10_013","DOI":"10.1007\/10_013"},{"issue":"12","key":"8_CR117","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.addr.2012.01.016","volume":"64","author":"TN Vo","year":"2012","unstructured":"Vo TN, Kasper FK, Mikos AG (2012) Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev 64(12):1292\u20131309. https:\/\/doi.org\/10.1016\/j.addr.2012.01.016","journal-title":"Adv Drug Deliv Rev"},{"key":"8_CR118","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0065-2776(07)95003-8","volume-title":"B-cell self-tolerance in humans advances in immunology","author":"H Wardemann","year":"2007","unstructured":"Wardemann H, Nussenzweig MC (2007) B-cell self-tolerance in humans advances in immunology, vol 95. Academic Press, San Diego, pp 83\u2013110. https:\/\/doi.org\/10.1016\/S0065-2776(07)95003-8"},{"key":"8_CR119","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13075-015-0824-x","volume":"17","author":"PR Wardwell","year":"2015","unstructured":"Wardwell PR, Forstner MB, Bader RA (2015) Investigation of the cytokine response to NF-kappa B decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models. Arthritis Res Ther 17:10. https:\/\/doi.org\/10.1186\/s13075-015-0824-x","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"8_CR120","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1084\/jem.174.6.1477","volume":"174","author":"JB Weinberg","year":"1991","unstructured":"Weinberg JB, Matthews TJ, Cullen BR, Malim MH (1991) Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes. J Exp Med 174(6):1477\u20131482. https:\/\/doi.org\/10.1084\/jem.174.6.1477","journal-title":"J Exp Med"},{"key":"8_CR121","doi-asserted-by":"publisher","first-page":"26316","DOI":"10.3402\/jev.v4.26316","volume":"4","author":"OP Wiklander","year":"2015","unstructured":"Wiklander OP, Nordin JZ, O\u2019Loughlin A, Gustafsson Y, Corso G, Mager I, Andaloussi SE (2015) Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J Extracell Vesicles 4:26316. https:\/\/doi.org\/10.3402\/jev.v4.26316","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"8_CR122","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1517\/17425247.2016.1165662","volume":"13","author":"XY Wu","year":"2016","unstructured":"Wu XY (2016) Strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery. Expert Opin Drug Deliv 13(5):609\u2013612. https:\/\/doi.org\/10.1517\/17425247.2016.1165662","journal-title":"Expert Opin Drug Deliv"},{"issue":"36","key":"8_CR123","first-page":"2557","volume":"87","author":"J Xu","year":"2007","unstructured":"Xu J, Zhu MY, Lu YH, Lu Y, Wang ZW (2007) Treatment of type 1 diabetes by transplantation of bone-derived mesenchymal stem cells expressing human insulin gene: experiment with mice. Zhonghua Yi Xue Za Zhi 87(36):2557\u20132560 ISSN: 0376-2491","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"17","key":"8_CR124","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/sj.gt.3302984","volume":"14","author":"K Yuasa","year":"2007","unstructured":"Yuasa K, Yoshimura M, Urasawa N, Ohshima S, Howell JM, Nakamura A, Takeda S (2007) Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products. Gene Ther 14(17):1249\u20131260. https:\/\/doi.org\/10.1038\/sj.gt.3302984","journal-title":"Gene Ther"},{"issue":"3","key":"8_CR125","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jconrel.2013.09.015","volume":"172","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Wang Z, Gemeinhart RA (2013) Progress in microRNA delivery. J Control Release 172(3):962\u2013974. https:\/\/doi.org\/10.1016\/j.jconrel.2013.09.015","journal-title":"J Control Release"},{"issue":"10","key":"8_CR126","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1038\/mt.2011.164","volume":"19","author":"X Zhuang","year":"2011","unstructured":"Zhuang X, Xiang X, Grizzl W, Sun D, Zhang S, Axtell RC, Zhang H-G (2011) Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther 19(10):1769\u20131779. https:\/\/doi.org\/10.1038\/mt.2011.164","journal-title":"Mol Ther"}],"container-title":["Advances in Experimental Medicine and Biology","Novel Biomaterials for Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-13-0947-2_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T06:34:45Z","timestamp":1759214085000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-981-13-0947-2_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9789811309465","9789811309472"],"references-count":126,"URL":"https:\/\/doi.org\/10.1007\/978-981-13-0947-2_8","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"25 October 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}