{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T06:22:55Z","timestamp":1742970175133,"version":"3.40.3"},"publisher-location":"Singapore","reference-count":139,"publisher":"Springer Singapore","isbn-type":[{"type":"print","value":"9789811589980"},{"type":"electronic","value":"9789811589997"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-981-15-8999-7_9","type":"book-chapter","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:03:16Z","timestamp":1609790596000},"page":"227-252","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrochemical Biosensing of Algal Toxins"],"prefix":"10.1007","author":[{"given":"Luis Angel","family":"Zambrano-Intriago","sequence":"first","affiliation":[]},{"given":"C\u00e9lia G.","family":"Amorim","sequence":"additional","affiliation":[]},{"given":"Joan Manuel","family":"Rodr\u00edguez-D\u00edaz","sequence":"additional","affiliation":[]},{"given":"Maria Concei\u00e7\u00e3o B. S. M.","family":"Montenegro","sequence":"additional","affiliation":[]},{"given":"Alberto N.","family":"Ara\u00fajo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"issue":"3","key":"9_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.procbio.2004.04.008","volume":"40","author":"Z Aksu","year":"2005","unstructured":"Aksu Z (2005) Application of biosorption for the removal of organic pollutants: a review. Process Biochem 40(3):997\u20131026. https:\/\/doi.org\/10.1016\/j.procbio.2004.04.008","journal-title":"Process Biochem"},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1590\/S1517-83822006000200017","volume":"37","author":"VPS Almeida","year":"2006","unstructured":"Almeida VPS, Cogo K, Tsai SM, Moon DH (2006) Colorimetric test for the monitoring of microcystins in cyanobacterial culture and environmental samples from Southeast\u2014Brazil. Braz J Microbiol 37:192\u2013198","journal-title":"Braz J Microbiol"},{"issue":"4","key":"9_CR3","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1007\/BF02804901","volume":"25","author":"DM Anderson","year":"2002","unstructured":"Anderson DM, Glibert PM, Burkholder JM (2002) Harmful algal blooms and eutrophication: nutrient sources, composition, and consequences. Estuaries 25(4):704\u2013726. https:\/\/doi.org\/10.1007\/BF02804901","journal-title":"Estuaries"},{"key":"9_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.saa.2018.10.039","volume":"209","author":"N Bagheri","year":"2019","unstructured":"Bagheri N, Khataee A, Hassanzadeh J, Habibi B (2019) Sensitive biosensing of organophosphate pesticides using enzyme mimics of magnetic ZIF-8. Spectrochim Acta A Mol Biomol Spectrosc 209:118\u2013125. https:\/\/doi.org\/10.1016\/j.saa.2018.10.039","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"9_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/047174199X","volume-title":"Fundamentals of electrochemistry","author":"VS Bagotsky","year":"2005","unstructured":"Bagotsky VS (2005) Fundamentals of electrochemistry. Wiley, Hoboken"},{"key":"9_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/9781118354162","volume-title":"Chemical sensors and biosensors: fundamentals and applications","author":"FG Banica","year":"2012","unstructured":"Banica FG (2012) Chemical sensors and biosensors: fundamentals and applications. Wiley, Hoboken"},{"issue":"3","key":"9_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/em.20539","volume":"51","author":"E Bazin","year":"2010","unstructured":"Bazin E, Mourot A, Humpage AR, Fessard V (2010) Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. Environ Mol Mutagen 51(3):251\u2013259. https:\/\/doi.org\/10.1002\/em.20539","journal-title":"Environ Mol Mutagen"},{"issue":"11","key":"9_CR8","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.3390\/s16111901","volume":"16","author":"MP Bilibana","year":"2016","unstructured":"Bilibana MP, Williams AR, Rassie C, Sunday CE, Makelane H, Wilson L, Ntshongontshi N, Jijana AN, Masikini M, Baker PGL, Iwuoha EI (2016) Electrochemical aptatoxisensor responses on nanocomposites containing electro-deposited silver nanoparticles on poly(propyleneimine) dendrimer for the detection of microcystin-LR in freshwater. Sensors 16(11):1901. https:\/\/doi.org\/10.3390\/s16111901","journal-title":"Sensors"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ecolind.2016.03.004","volume":"67","author":"H Blaas","year":"2016","unstructured":"Blaas H, Kroeze C (2016) Excessive nitrogen and phosphorus in European rivers: 2000\u20132050. Ecol Indic 67:328\u2013337. https:\/\/doi.org\/10.1016\/j.ecolind.2016.03.004","journal-title":"Ecol Indic"},{"issue":"4","key":"9_CR10","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/j.1476-5381.1977.tb07561.x","volume":"61","author":"HL Borison","year":"1977","unstructured":"Borison HL, McCarthy LE (1977) Respiratory and circulatory effects of saxitoxin in the cerebrospinal fluid. Br J Pharmacol 61(4):679\u2013689. https:\/\/doi.org\/10.1111\/j.1476-5381.1977.tb07561.x","journal-title":"Br J Pharmacol"},{"issue":"1\u20132","key":"9_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.toxlet.2003.12.005","volume":"148","author":"N Boua\u00efcha","year":"2004","unstructured":"Boua\u00efcha N, Maatouk I (2004) Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes. Toxicol Lett 148(1\u20132):53\u201363. https:\/\/doi.org\/10.1016\/j.toxlet.2003.12.005","journal-title":"Toxicol Lett"},{"issue":"4","key":"9_CR12","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/elan.201600652","volume":"29","author":"S Bratakou","year":"2017","unstructured":"Bratakou S, Nikoleli G-P, Siontorou CG, Nikolelis DP, Karapetis S, Tzamtzis N (2017) Development of an electrochemical biosensor for the rapid detection of Saxitoxin based on air stable lipid films with incorporated anti-STX using graphene electrodes. Electroanalysis 29(4):990\u2013997. https:\/\/doi.org\/10.1002\/elan.201600652","journal-title":"Electroanalysis"},{"key":"9_CR13","volume-title":"Electrochemistry: principles, methods, and applications","author":"CMA Brett","year":"1993","unstructured":"Brett CMA, Brett AMO (1993) Electrochemistry: principles, methods, and applications. Oxford University Press, Oxford"},{"issue":"1","key":"9_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3390\/ijms11010268","volume":"11","author":"A Campos","year":"2010","unstructured":"Campos A, Vasconcelos V (2010) Molecular mechanisms of microcystin toxicity in animal cells. Int J Mol Sci 11(1):268\u2013287. https:\/\/doi.org\/10.3390\/ijms11010268","journal-title":"Int J Mol Sci"},{"issue":"6","key":"9_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2672.1992.tb01858.x","volume":"72","author":"WW Carmichael","year":"1992","unstructured":"Carmichael WW (1992) Cyanobacteria secondary metabolites\u2014the cyanotoxins. J Appl Bacteriol 72(6):445\u2013459. https:\/\/doi.org\/10.1111\/j.1365-2672.1992.tb01858.x","journal-title":"J Appl Bacteriol"},{"issue":"1","key":"9_CR16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/05384680.1978.11903972","volume":"21","author":"WW Carmichael","year":"1978","unstructured":"Carmichael WW, Gorham PR (1978) Anatoxins from clones of Anabaena flos-aquae isolated from lakes of western Canada. SIL Commun 21(1):285\u2013295. https:\/\/doi.org\/10.1080\/05384680.1978.11903972","journal-title":"SIL Commun"},{"issue":"3","key":"9_CR17","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1461-0248.2005.00877.x","volume":"9","author":"SR Carpenter","year":"2006","unstructured":"Carpenter SR, Brock WA (2006) Rising variance: a leading indicator of ecological transition. Ecol Lett 9(3):311\u2013318. https:\/\/doi.org\/10.1111\/j.1461-0248.2005.00877.x","journal-title":"Ecol Lett"},{"issue":"3","key":"9_CR18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1890\/1051-0761(1998)008[0559:NPOSWW]2.0.CO;2","volume":"8","author":"SR Carpenter","year":"1998","unstructured":"Carpenter SR, Caraco NF, Correll DL, Howarth RW, Sharpley AN, Smith VH (1998) Nonpoint pollution of surface waters with phosphorus and nitrogen. Ecol Appl 8(3):559\u2013568. https:\/\/doi.org\/10.1890\/1051-0761(1998)008[0559:NPOSWW]2.0.CO;2","journal-title":"Ecol Appl"},{"issue":"2","key":"9_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1006\/immu.1993.1047","volume":"3","author":"RM Carter","year":"1993","unstructured":"Carter RM, Poli MA, Pesavento M, Sibley DET, Lubrano GJ, Guilbault GG (1993) Immunoelectrochemical biosensors for detection of saxitoxin and brevetoxin. Immuno Methods 3(2):128\u2013133. https:\/\/doi.org\/10.1006\/immu.1993.1047","journal-title":"Immuno Methods"},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cca.2013.07.005","volume":"425","author":"Y Chen","year":"2013","unstructured":"Chen Y, Shen D, Fang D (2013) Nodularins in poisoning. Clin Chim Acta 425:18\u201329. https:\/\/doi.org\/10.1016\/j.cca.2013.07.005","journal-title":"Clin Chim Acta"},{"issue":"3","key":"9_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/jat.1586","volume":"31","author":"N Chernoff","year":"2011","unstructured":"Chernoff N, Rogers EH, Zehr RD, Gage MI, Malarkey DE, Bradfield CA, Liu Y, Schmid JE, Jaskot RH, Richards JH, Wood CR, Rosen MB (2011) Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin. J Appl Toxicol 31(3):242\u2013254. https:\/\/doi.org\/10.1002\/jat.1586","journal-title":"J Appl Toxicol"},{"key":"9_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/978-3-642-59514-1_2","volume-title":"Cyanotoxins: occurrence, causes, consequences","author":"I Chorus","year":"2001","unstructured":"Chorus I (2001) Cyanotoxin occurrence in freshwaters. In: Chorus I (ed) Cyanotoxins: occurrence, causes, consequences. Springer, Berlin, pp 5\u2013101. https:\/\/doi.org\/10.1007\/978-3-642-59514-1_2"},{"key":"9_CR23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3354\/meps210223","volume":"210","author":"J Cloern","year":"2001","unstructured":"Cloern J (2001) Our evolving conceptual model of the coastal eutrophication problem. Mar Ecol Prog Ser 210:223\u2013253. https:\/\/doi.org\/10.3354\/meps210223","journal-title":"Mar Ecol Prog Ser"},{"issue":"4","key":"9_CR24","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3390\/md11040991","volume":"11","author":"DK Cusick","year":"2013","unstructured":"Cusick DK, Sayler SG (2013) An overview on the marine neurotoxin, saxitoxin: genetics, molecular targets, methods of detection and ecological functions. Mar Drugs 11(4):991. https:\/\/doi.org\/10.3390\/md11040991","journal-title":"Mar Drugs"},{"issue":"2","key":"9_CR25","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ecoenv.2004.04.006","volume":"59","author":"DR de Figueiredo","year":"2004","unstructured":"de Figueiredo DR, Azeiteiro UM, Esteves SM, Gon\u00e7alves FJM, Pereira MJ (2004) Microcystin-producing blooms\u2014a serious global public health issue. Ecotoxicol Environ Saf 59(2):151\u2013163. https:\/\/doi.org\/10.1016\/j.ecoenv.2004.04.006","journal-title":"Ecotoxicol Environ Saf"},{"issue":"11","key":"9_CR26","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1039\/C3EM00353A","volume":"15","author":"AA de la Cruz","year":"2013","unstructured":"de la Cruz AA, Hiskia A, Kaloudis T, Chernoff N, Hill D, Antoniou MG, He X, Loftin K, O'Shea K, Zhao C, Pelaez M, Han C, Lynch TJ, Dionysiou DD (2013) A review on cylindrospermopsin: the global occurrence, detection, toxicity and degradation of a potent cyanotoxin. Environ Sci: Processes Impacts 15(11):1979\u20132003. https:\/\/doi.org\/10.1039\/C3EM00353A","journal-title":"Environ Sci: Processes Impacts"},{"key":"9_CR27","doi-asserted-by":"crossref","DOI":"10.1002\/9780470511305","volume-title":"Chemical sensors and biosensors","author":"BR Eggins","year":"2002","unstructured":"Eggins BR (2002) Chemical sensors and biosensors. Wiley, Hoboken"},{"issue":"15","key":"9_CR28","doi-asserted-by":"publisher","first-page":"7551","DOI":"10.1021\/ac501335k","volume":"86","author":"S Eissa","year":"2014","unstructured":"Eissa S, Ng A, Siaj M, Zourob M (2014) Label-free voltammetric aptasensor for the sensitive detection of microcystin-LR using graphene-modified electrodes. Anal Chem 86(15):7551\u20137557. https:\/\/doi.org\/10.1021\/ac501335k","journal-title":"Anal Chem"},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.bios.2015.01.055","volume":"69","author":"S Eissa","year":"2015","unstructured":"Eissa S, Siaj M, Zourob M (2015) Aptamer-based competitive electrochemical biosensor for brevetoxin-2. Biosens Bioelectron 69:148\u2013154. https:\/\/doi.org\/10.1016\/j.bios.2015.01.055","journal-title":"Biosens Bioelectron"},{"issue":"18","key":"9_CR30","doi-asserted-by":"publisher","first-page":"9196","DOI":"10.1021\/ac502157g","volume":"86","author":"R Elshafey","year":"2014","unstructured":"Elshafey R, Siaj M, Zourob M (2014) In vitro selection, characterization, and biosensing application of high-affinity cylindrospermopsin-targeting aptamers. Anal Chem 86(18):9196\u20139203. https:\/\/doi.org\/10.1021\/ac502157g","journal-title":"Anal Chem"},{"key":"9_CR31","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.bios.2015.01.002","volume":"68","author":"R Elshafey","year":"2015","unstructured":"Elshafey R, Siaj M, Zourob M (2015) DNA aptamers selection and characterization for development of label-free impedimetric aptasensor for neurotoxin anatoxin-a. Biosens Bioelectron 68:295\u2013302. https:\/\/doi.org\/10.1016\/j.bios.2015.01.002","journal-title":"Biosens Bioelectron"},{"key":"9_CR32","unstructured":"EPA (2015) Method 545: determination of cylindrospermopsin and Anatoxin-a in drinking water by liquid chromatography electrospray ionization tandem mass spectrometry (LC\/ESI-MS\/MS). EPA 815-R-15-009. U.S. Environmental Protection Agency"},{"key":"9_CR33","unstructured":"EPA (2019) Determination of cyanotoxins in drinking and ambient freshwaters. United States Environmental Protection Agency. https:\/\/www.epa.gov\/cyanohabs\/determination-cyanotoxins-drinking-and-ambient-freshwaters"},{"issue":"2","key":"9_CR34","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0041-0101(88)90168-7","volume":"26","author":"JE Eriksson","year":"1988","unstructured":"Eriksson JE, Meriluoto JAO, Kujari HP, \u00d6sterlund K, Fagerlund K, H\u00c4llbom L (1988) Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena. Toxicon 26(2):161\u2013166. https:\/\/doi.org\/10.1016\/0041-0101(88)90168-7","journal-title":"Toxicon"},{"key":"9_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-40241-8_1","volume-title":"Biosensors: essentials","author":"G Evtugyn","year":"2014","unstructured":"Evtugyn G (2014) Introduction and overview of history. In: Evtugyn G (ed) Biosensors: essentials. Springer, Berlin, pp 1\u201320. https:\/\/doi.org\/10.1007\/978-3-642-40241-8_1"},{"issue":"1","key":"9_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<143::AID-TOX18>3.0.CO;2-H","volume":"14","author":"IR Falconer","year":"1999","unstructured":"Falconer IR, Hardy SJ, Humpage AR, Froscio SM, Tozer GJ, Hawkins PR (1999) Hepatic and renal toxicity of the blue\u2013green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice. Environ Toxicol 14(1):143\u2013150. https:\/\/doi.org\/10.1002\/(SICI)1522-7278(199902)14:1<143::AID-TOX18>3.0.CO;2-H","journal-title":"Environ Toxicol"},{"issue":"4","key":"9_CR37","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/tox.10121","volume":"18","author":"SM Froscio","year":"2003","unstructured":"Froscio SM, Humpage AR, Burcham PC, Falconer IR (2003) Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes. Environ Toxicol 18(4):243\u2013251. https:\/\/doi.org\/10.1002\/tox.10121","journal-title":"Environ Toxicol"},{"issue":"12","key":"9_CR38","doi-asserted-by":"publisher","first-page":"8245","DOI":"10.1166\/jnn.2013.7936","volume":"13","author":"X Fu","year":"2013","unstructured":"Fu X, Feng Y, Niu S, Zhao C, Yang M, Yang Y (2013) Sensitive detection of microcystin-LR by using a label-free electrochemical immunosensor based on au nanoparticles\/silicon template\/methylene blue nanocomposite. J Nanosci Nanotechnol 13(12):8245\u20138252. https:\/\/doi.org\/10.1166\/jnn.2013.7936","journal-title":"J Nanosci Nanotechnol"},{"issue":"3","key":"9_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1080\/03067319.2016.1150460","volume":"96","author":"X Fu","year":"2016","unstructured":"Fu X, Zhao C, Liu X, Zhao J, Niu X, Zheng L, Yang Y (2016) A layer-by-layer assembly label-free electrochemical immunosensor for the detection of microcystin-LR based on CHIT\/PAMAM dendrimer\/silver nanocubes. Int J Environ Anal Chem 96(3):284\u2013297. https:\/\/doi.org\/10.1080\/03067319.2016.1150460","journal-title":"Int J Environ Anal Chem"},{"key":"9_CR40","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bios.2015.11.072","volume":"78","author":"C Gan","year":"2016","unstructured":"Gan C, Ling L, He Z, Lei H, Liu Y (2016a) In-situ assembly of biocompatible core\u2013shell hierarchical nanostructures sensitized immunosensor for microcystin-LR detection. Biosens Bioelectron 78:381\u2013389. https:\/\/doi.org\/10.1016\/j.bios.2015.11.072","journal-title":"Biosens Bioelectron"},{"issue":"57","key":"9_CR41","doi-asserted-by":"publisher","first-page":"51662","DOI":"10.1039\/C6RA07881H","volume":"6","author":"C Gan","year":"2016","unstructured":"Gan C, Sun Z, Ling L, He Z, Lei H, Liu Y (2016b) Construction of portable electrochemical immunosensors based on graphene hydrogel@polydopamine for microcystin-LR detection using multi-mesoporous carbon sphere-enzyme labels. RSC Adv 6(57):51662\u201351669. https:\/\/doi.org\/10.1039\/C6RA07881H","journal-title":"RSC Adv"},{"issue":"2","key":"9_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.toxicon.2003.11.018","volume":"43","author":"C Garc\u0131\u0301a","year":"2004","unstructured":"Garc\u0131\u0301a C, Ma d CB, Lagos M, Lagos N (2004) Paralytic shellfish poisoning: post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords. Toxicon 43(2):149\u2013158. https:\/\/doi.org\/10.1016\/j.toxicon.2003.11.018","journal-title":"Toxicon"},{"key":"9_CR43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.hal.2016.09.007","volume":"59","author":"CM Gibble","year":"2016","unstructured":"Gibble CM, Peacock MB, Kudela RM (2016) Evidence of freshwater algal toxins in marine shellfish: implications for human and aquatic health. Harmful Algae 59:59\u201366. https:\/\/doi.org\/10.1016\/j.hal.2016.09.007","journal-title":"Harmful Algae"},{"issue":"1","key":"9_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hal.2008.08.020","volume":"8","author":"PM Glibert","year":"2008","unstructured":"Glibert PM, Burkholder JM, Graneli E, Anderson DM (2008) Advances and insights in the complex relationships between eutrophication and HABs: preface to the special issue. Harmful Algae 8(1):1\u20132. https:\/\/doi.org\/10.1016\/j.hal.2008.08.020","journal-title":"Harmful Algae"},{"issue":"3","key":"9_CR45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S1093-0191(03)00032-7","volume":"8","author":"PR Gogate","year":"2004","unstructured":"Gogate PR, Pandit AB (2004) A review of imperative technologies for wastewater treatment I: oxidation technologies at ambient conditions. Adv Environ Res 8(3):501\u2013551. https:\/\/doi.org\/10.1016\/S1093-0191(03)00032-7","journal-title":"Adv Environ Res"},{"issue":"13","key":"9_CR46","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1021\/ac048431d","volume":"77","author":"M\u00c1 Gonz\u00e1lez-Mart\u00ednez","year":"2005","unstructured":"Gonz\u00e1lez-Mart\u00ednez M\u00c1, Brun EM, Puchades R, Maquieira \u00c1, Ramsey K, Rubio F (2005) Glyphosate immunosensor. Application for water and soil analysis. Anal Chem 77(13):4219\u20134227. https:\/\/doi.org\/10.1021\/ac048431d","journal-title":"Anal Chem"},{"key":"9_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.hal.2019.03.008","volume":"91","author":"AW Griffith","year":"2020","unstructured":"Griffith AW, Gobler CJ (2020) Harmful algal blooms: a climate change co-stressor in marine and freshwater ecosystems. Harmful Algae 91:101590. https:\/\/doi.org\/10.1016\/j.hal.2019.03.008","journal-title":"Harmful Algae"},{"issue":"2","key":"9_CR48","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/j.1365-2486.2011.02576.x","volume":"18","author":"B Grizzetti","year":"2012","unstructured":"Grizzetti B, Bouraoui F, Aloe A (2012) Changes of nitrogen and phosphorus loads to European seas. Glob Chang Biol 18(2):769\u2013782. https:\/\/doi.org\/10.1111\/j.1365-2486.2011.02576.x","journal-title":"Glob Chang Biol"},{"issue":"4","key":"9_CR49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s40828-017-0052-x","volume":"3","author":"P Gr\u00fcndler","year":"2017","unstructured":"Gr\u00fcndler P (2017) Chemical sensors. Chem Texts 3(4):16. https:\/\/doi.org\/10.1007\/s40828-017-0052-x","journal-title":"Chem Texts"},{"issue":"7","key":"9_CR50","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.toxicon.2005.02.031","volume":"45","author":"M Gugger","year":"2005","unstructured":"Gugger M, Lenoir S, Berger C, Ledreux A, Druart J-C, Humbert J-F, Guette C, Bernard C (2005) First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon 45(7):919\u2013928. https:\/\/doi.org\/10.1016\/j.toxicon.2005.02.031","journal-title":"Toxicon"},{"issue":"2\u20133","key":"9_CR51","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/s0300-483x(03)00112-4","volume":"188","author":"N Gupta","year":"2003","unstructured":"Gupta N, Pant SC, Vijayaraghavan R, Rao PV (2003) Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 188(2\u20133):285\u2013296. https:\/\/doi.org\/10.1016\/s0300-483x(03)00112-4","journal-title":"Toxicology"},{"key":"9_CR52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.aquatox.2015.01.024","volume":"161","author":"R Guzm\u00e1n-Guill\u00e9n","year":"2015","unstructured":"Guzm\u00e1n-Guill\u00e9n R, Manzano IL, Moreno IM, Ortega AIP, Moyano R, Blanco A, Came\u00e1n AM (2015) Cylindrospermopsin induces neurotoxicity in tilapia fish (Oreochromis niloticus) exposed to Aphanizomenon ovalisporum. Aquat Toxicol 161:17\u201324. https:\/\/doi.org\/10.1016\/j.aquatox.2015.01.024","journal-title":"Aquat Toxicol"},{"issue":"14","key":"9_CR53","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1002\/adfm.201201920","volume":"23","author":"C Han","year":"2013","unstructured":"Han C, Doepke A, Cho W, Likodimos V, de la Cruz AA, Back T, Heineman WR, Halsall HB, Shanov VN, Schulz MJ, Falaras P, Dionysiou DD (2013) A multiwalled-carbon-nanotube-based biosensor for monitoring microcystin-LR in sources of drinking water supplies. Adv Funct Mater 23(14):1807\u20131816. https:\/\/doi.org\/10.1002\/adfm.201201920","journal-title":"Adv Funct Mater"},{"key":"9_CR54","unstructured":"Hance J (2020) Lethal algae blooms\u2014an ecosystem out of balance. https:\/\/www.theguardian.com\/environment\/2020\/jan\/04\/lethal-algae-blooms-an-ecosystem-out-of-balance"},{"issue":"13","key":"9_CR55","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1016\/S0043-1354(01)00018-5","volume":"35","author":"T Heresztyn","year":"2001","unstructured":"Heresztyn T, Nicholson BC (2001) Determination of cyanobacterial hepatotoxins directly in water using a protein phosphatase inhibition assay. Water Res 35(13):3049\u20133056. https:\/\/doi.org\/10.1016\/S0043-1354(01)00018-5","journal-title":"Water Res"},{"issue":"1","key":"9_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1466-822X.2006.00212.x","volume":"15","author":"RJ Hobbs","year":"2006","unstructured":"Hobbs RJ, Arico S, Aronson J, Baron JS, Bridgewater P, Cramer VA, Epstein PR, Ewel JJ, Klink CA, Lugo AE, Norton D, Ojima D, Richardson DM, Sanderson EW, Valladares F, Vil\u00e0 M, Zamora R, Zobel M (2006) Novel ecosystems: theoretical and management aspects of the new ecological world order. Glob Ecol Biogeogr 15(1):1\u20137. https:\/\/doi.org\/10.1111\/j.1466-822X.2006.00212.x","journal-title":"Glob Ecol Biogeogr"},{"key":"9_CR57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.snb.2016.04.034","volume":"233","author":"L Hou","year":"2016","unstructured":"Hou L, Ding Y, Zhang L, Guo Y, Li M, Chen Z, Wu X (2016a) An ultrasensitive competitive immunosensor for impedimetric detection of microcystin-LR via antibody-conjugated enzymatic biocatalytic precipitation. Sens Actuators B 233:63\u201370. https:\/\/doi.org\/10.1016\/j.snb.2016.04.034","journal-title":"Sens Actuators B"},{"issue":"6","key":"9_CR58","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1007\/s00604-016-1836-1","volume":"183","author":"L Hou","year":"2016","unstructured":"Hou L, Jiang L, Song Y, Ding Y, Zhang J, Wu X, Tang D (2016b) Amperometric aptasensor for saxitoxin using a gold electrode modified with carbon nanotubes on a self-assembled monolayer, and methylene blue as an electrochemical indicator probe. Microchim Acta 183(6):1971\u20131980. https:\/\/doi.org\/10.1007\/s00604-016-1836-1","journal-title":"Microchim Acta"},{"key":"9_CR59","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-75865-7","volume-title":"Cyanobacterial harmful algal blooms: state of the science and research needs","author":"HK Hudnell","year":"2008","unstructured":"Hudnell HK (2008) Cyanobacterial harmful algal blooms: state of the science and research needs. Springer, New York"},{"issue":"9","key":"9_CR60","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1351\/pac199163091247","volume":"63","author":"A Hulanicki","year":"1991","unstructured":"Hulanicki A, Glab S, Ingman F (1991) Chemical sensors: definitions and classification. Pure Appl Chem 63(9):1247\u20131250. https:\/\/doi.org\/10.1351\/pac199163091247","journal-title":"Pure Appl Chem"},{"key":"9_CR61","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/B978-012374484-5.00027-4","volume-title":"Handbook of toxicology of chemical warfare agents","author":"JF Humbert","year":"2009","unstructured":"Humbert JF (2009) Toxins of cyanobacteria. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents. Academic Press, San Diego, pp 371\u2013379. https:\/\/doi.org\/10.1016\/B978-012374484-5.00027-4"},{"issue":"4","key":"9_CR62","doi-asserted-by":"publisher","first-page":"378","DOI":"10.5811\/westjem.2014.4.16279","volume":"15","author":"W Hurley","year":"2014","unstructured":"Hurley W, Wolterstorff C, MacDonald R, Schultz D (2014) Paralytic shellfish poisoning: a case series. West J Emerg Med 15(4):378\u2013381. https:\/\/doi.org\/10.5811\/westjem.2014.4.16279","journal-title":"West J Emerg Med"},{"issue":"2\u20133","key":"9_CR63","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.tox.2005.12.007","volume":"220","author":"R Jayaraj","year":"2006","unstructured":"Jayaraj R, Anand T, Rao PV (2006) Activity and gene expression profile of certain antioxidant enzymes to microcystin-LR induced oxidative stress in mice. Toxicology 220(2\u20133):136\u2013146. https:\/\/doi.org\/10.1016\/j.tox.2005.12.007","journal-title":"Toxicology"},{"issue":"3","key":"9_CR64","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/BF02492136","volume":"55","author":"HT Kankaanp\u00e4\u00e4","year":"2002","unstructured":"Kankaanp\u00e4\u00e4 HT, Vuorensola KM, Sipi\u00e4 VO, Meriluoto JAO (2002) Chromatographic and spectral behaviour and detection of hepatotoxic nodularin in fish, clam, mussel and mouse tissues using HPLC analysis. Chromatographia 55(3):157\u2013162. https:\/\/doi.org\/10.1007\/BF02492136","journal-title":"Chromatographia"},{"issue":"1","key":"9_CR65","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1113\/jphysiol.1965.sp007688","volume":"180","author":"CY Kao","year":"1965","unstructured":"Kao CY, Nishiyama A (1965) Actions of saxitoxin on peripheral neuromuscular systems. J Physiol 180(1):50\u201366","journal-title":"J Physiol"},{"issue":"2","key":"9_CR66","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1021\/ac202878q","volume":"84","author":"DW Kimmel","year":"2012","unstructured":"Kimmel DW, LeBlanc G, Meschievitz ME, Cliffel DE (2012) Electrochemical sensors and biosensors. Anal Chem 84(2):685\u2013707. https:\/\/doi.org\/10.1021\/ac202878q","journal-title":"Anal Chem"},{"issue":"9","key":"9_CR67","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1021\/ed060p702","volume":"60","author":"PT Kissinger","year":"1983","unstructured":"Kissinger PT, Heineman WR (1983) Cyclic voltammetry. J Chem Educ 60(9):702. https:\/\/doi.org\/10.1021\/ed060p702","journal-title":"J Chem Educ"},{"key":"9_CR68","doi-asserted-by":"publisher","DOI":"10.1201\/9781315274263","volume-title":"Laboratory techniques in Electroanalytical chemistry, revised and expanded","author":"P Kissinger","year":"2018","unstructured":"Kissinger P, Heineman WR (2018) Laboratory techniques in Electroanalytical chemistry, revised and expanded. CRC Press, Boca Raton"},{"issue":"4","key":"9_CR69","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1021\/es00053a032","volume":"28","author":"TW Lambert","year":"1994","unstructured":"Lambert TW, Boland MP, Holmes CF, Hrudey SE (1994) Quantitation of the microcystin hepatotoxins in water at environmentally relevant concentrations with the protein phosphatase bioassay. Environ Sci Technol 28(4):753\u2013755. https:\/\/doi.org\/10.1021\/es00053a032","journal-title":"Environ Sci Technol"},{"key":"9_CR70","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.talanta.2012.10.081","volume":"103","author":"Z Lin","year":"2013","unstructured":"Lin Z, Huang H, Xu Y, Gao X, Qiu B, Chen X, Chen G (2013) Determination of microcystin-LR in water by a label-free aptamer based electrochemical impedance biosensor. Talanta 103:371\u2013374. https:\/\/doi.org\/10.1016\/j.talanta.2012.10.081","journal-title":"Talanta"},{"issue":"10","key":"9_CR71","doi-asserted-by":"publisher","first-page":"5504","DOI":"10.1021\/es2041042","volume":"46","author":"M Lotierzo","year":"2012","unstructured":"Lotierzo M, Abuknesha R, Davis F, Tothill IE (2012) A membrane-based ELISA assay and electrochemical Immunosensor for microcystin-LR in water samples. Environ Sci Technol 46(10):5504\u20135510. https:\/\/doi.org\/10.1021\/es2041042","journal-title":"Environ Sci Technol"},{"issue":"1","key":"9_CR72","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.bios.2008.03.016","volume":"24","author":"S Loyprasert","year":"2008","unstructured":"Loyprasert S, Thavarungkul P, Asawatreratanakul P, Wongkittisuksa B, Limsakul C, Kanatharana P (2008) Label-free capacitive immunosensor for microcystin-LR using self-assembled thiourea monolayer incorporated with Ag nanoparticles on gold electrode. Biosens Bioelectron 24(1):78\u201386. https:\/\/doi.org\/10.1016\/j.bios.2008.03.016","journal-title":"Biosens Bioelectron"},{"issue":"5","key":"9_CR73","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/aaee3f","volume":"30","author":"X Lu","year":"2019","unstructured":"Lu X, Li Y, Tao L, Song D, Wang Y, Li Y, Gao F (2019) Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides. Nanotechnology 30(5):055501. https:\/\/doi.org\/10.1088\/1361-6528\/aaee3f","journal-title":"Nanotechnology"},{"issue":"5","key":"9_CR74","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0041-0101(86)90074-7","volume":"24","author":"NA Mahmood","year":"1986","unstructured":"Mahmood NA, Carmichael WW (1986) The pharmacology of anatoxin-a(s), a neurotoxin produced by the freshwater cyanobacterium Anabaena flos-aquae NRC 525-17. Toxicon 24(5):425\u2013434. https:\/\/doi.org\/10.1016\/0041-0101(86)90074-7","journal-title":"Toxicon"},{"key":"9_CR75","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/B978-0-12-819090-6.00031-3","volume-title":"Handbook of toxicology of chemical warfare agents","author":"JK Malik","year":"2020","unstructured":"Malik JK, Bharti VK, Rahal A, Kumar D, Gupta RC (2020) Cyanobacterial (blue-green algae) toxins. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents, 3rd edn. Academic Press, Boston, pp 467\u2013478. https:\/\/doi.org\/10.1016\/B978-0-12-819090-6.00031-3","edition":"3"},{"key":"9_CR76","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.toxicon.2018.07.010","volume":"151","author":"IY Massey","year":"2018","unstructured":"Massey IY, Yang F, Ding Z, Yang S, Guo J, Tezi C, Al-Osman M, Kamegni RB, Zeng W (2018) Exposure routes and health effects of microcystins on animals and humans: a mini-review. Toxicon 151:156\u2013162. https:\/\/doi.org\/10.1016\/j.toxicon.2018.07.010","journal-title":"Toxicon"},{"issue":"2","key":"9_CR77","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.limno.2008.09.001","volume":"39","author":"V Messineo","year":"2009","unstructured":"Messineo V, Bogialli S, Melchiorre S, Sechi N, Lugli\u00e8 A, Casiddu P, Mariani MA, Padedda BM, Corcia AD, Mazza R, Carloni E, Bruno M (2009) Cyanobacterial toxins in Italian freshwaters. Limnologica 39(2):95\u2013106. https:\/\/doi.org\/10.1016\/j.limno.2008.09.001","journal-title":"Limnologica"},{"key":"9_CR78","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bcab.2018.11.029","volume":"17","author":"SK Metkar","year":"2019","unstructured":"Metkar SK, Girigoswami K (2019) Diagnostic biosensors in medicine\u2014a review. Biocatal Agric Biotechnol 17:271\u2013283. https:\/\/doi.org\/10.1016\/j.bcab.2018.11.029","journal-title":"Biocatal Agric Biotechnol"},{"key":"9_CR79","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-73740-7","volume-title":"Square-wave voltammetry: theory and application","author":"V Mirceski","year":"2007","unstructured":"Mirceski V, Komorsky-Lovric S, Lovric M (2007) Square-wave voltammetry: theory and application. Springer, Berlin"},{"issue":"9","key":"9_CR80","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/foods7090141","volume":"7","author":"GK Mishra","year":"2018","unstructured":"Mishra GK, Barfidokht A, Tehrani F, Mishra RK (2018) Food safety analysis using electrochemical biosensors. Foods 7(9):141. https:\/\/doi.org\/10.3390\/foods7090141","journal-title":"Foods"},{"issue":"4","key":"9_CR81","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.aquatox.2006.03.011","volume":"78","author":"TAM Msagati","year":"2006","unstructured":"Msagati TAM, Siame BA, Shushu DD (2006) Evaluation of methods for the isolation, detection and quantification of cyanobacterial hepatotoxins. Aquat Toxicol 78(4):382\u2013397. https:\/\/doi.org\/10.1016\/j.aquatox.2006.03.011","journal-title":"Aquat Toxicol"},{"issue":"19","key":"9_CR82","doi-asserted-by":"publisher","first-page":"10697","DOI":"10.1021\/es301686k","volume":"46","author":"A Ng","year":"2012","unstructured":"Ng A, Chinnappan R, Eissa S, Liu H, Tlili C, Zourob M (2012) Selection, characterization, and biosensing application of high affinity congener-specific microcystin-targeting aptamers. Environ Sci Technol 46(19):10697\u201310703. https:\/\/doi.org\/10.1021\/es301686k","journal-title":"Environ Sci Technol"},{"issue":"8","key":"9_CR83","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.envint.2007.06.003","volume":"33","author":"J Osswald","year":"2007","unstructured":"Osswald J, Rell\u00e1n S, Gago A, Vasconcelos V (2007) Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a. Environ Int 33(8):1070\u20131089. https:\/\/doi.org\/10.1016\/j.envint.2007.06.003","journal-title":"Environ Int"},{"issue":"3","key":"9_CR84","doi-asserted-by":"publisher","first-page":"129","DOI":"10.31482\/mmsl.2011.019","volume":"80","author":"J Pato\u010dka","year":"2011","unstructured":"Pato\u010dka J, Gupta CR, Ku\u010da K (2011) Anatoxin-A(S): natural organophosphorus anticholinesterase agent. MMSL 80(3):129\u2013139. https:\/\/doi.org\/10.31482\/mmsl.2011.019","journal-title":"MMSL"},{"issue":"5","key":"9_CR85","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.3390\/md8051650","volume":"8","author":"L Pearson","year":"2010","unstructured":"Pearson L, Mihali T, Moffitt M, Kellmann R, Neilan B (2010) On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin. Mar Drugs 8(5):1650\u20131680. https:\/\/doi.org\/10.3390\/md8051650","journal-title":"Mar Drugs"},{"key":"9_CR86","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/B978-0-12-385926-6.00083-1","volume-title":"Veterinary toxicology","author":"B Puschner","year":"2012","unstructured":"Puschner B, Roegner A (2012) Cyanobacterial (blue-green algae) toxins. In: Gupta RC (ed) Veterinary toxicology, 2nd edn. Academic Press, Boston, pp 953\u2013965. https:\/\/doi.org\/10.1016\/B978-0-12-385926-6.00083-1","edition":"2"},{"issue":"4","key":"9_CR87","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/sj.gt.3302900","volume":"14","author":"NS Que-Gewirth","year":"2007","unstructured":"Que-Gewirth NS, Sullenger BA (2007) Gene therapy progress and prospects: RNA aptamers. Gene Ther 14(4):283\u2013291. https:\/\/doi.org\/10.1038\/sj.gt.3302900","journal-title":"Gene Ther"},{"key":"9_CR88","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/863196","volume":"2011","author":"A-E Radi","year":"2011","unstructured":"Radi A-E (2011) Electrochemical aptamer-based biosensors: recent advances and perspectives. Int J Electrochem 2011:863196. https:\/\/doi.org\/10.4061\/2011\/863196","journal-title":"Int J Electrochem"},{"issue":"2","key":"9_CR89","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0003-2670(02)00588-3","volume":"466","author":"J Rapala","year":"2002","unstructured":"Rapala J, Erkomaa K, Kukkonen J, Sivonen K, Lahti K (2002) Detection of microcystins with protein phosphatase inhibition assay, high-performance liquid chromatography\u2013UV detection and enzyme-linked immunosorbent assay: comparison of methods. Anal Chim Acta 466(2):213\u2013231. https:\/\/doi.org\/10.1016\/S0003-2670(02)00588-3","journal-title":"Anal Chim Acta"},{"issue":"1","key":"9_CR90","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/bios9010020","volume":"9","author":"E Reynoso","year":"2019","unstructured":"Reynoso E, Torres E, Bettazzi F, Palchetti I (2019) Trends and perspectives in immunosensors for determination of currently-used pesticides: the case of glyphosate, organophosphates, and neonicotinoids. Biosensors 9(1):20. https:\/\/doi.org\/10.3390\/bios9010020","journal-title":"Biosensors"},{"issue":"5","key":"9_CR91","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1039\/b714449k","volume":"39","author":"NJ Ronkainen","year":"2010","unstructured":"Ronkainen NJ, Halsall HB, Heineman WR (2010) Electrochemical biosensors. Chem Soc Rev 39(5):1747\u20131763. https:\/\/doi.org\/10.1039\/b714449k","journal-title":"Chem Soc Rev"},{"key":"9_CR92","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bios.2018.01.023","volume":"105","author":"M Rubab","year":"2018","unstructured":"Rubab M, Shahbaz HM, Olaimat AN, Oh DH (2018) Biosensors for rapid and sensitive detection of Staphylococcus aureus in food. Biosens Bioelectron 105:49\u201357. https:\/\/doi.org\/10.1016\/j.bios.2018.01.023","journal-title":"Biosens Bioelectron"},{"key":"9_CR93","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bios.2013.01.007","volume":"44","author":"L Ruiyi","year":"2013","unstructured":"Ruiyi L, Qianfang X, Zaijun L, Xiulan S, Junkang L (2013) Electrochemical immunosensor for ultrasensitive detection of microcystin-LR based on graphene\u2013gold nanocomposite\/functional conducting polymer\/gold nanoparticle\/ionic liquid composite film with electrodeposition. Biosens Bioelectron 44:235\u2013240. https:\/\/doi.org\/10.1016\/j.bios.2013.01.007","journal-title":"Biosens Bioelectron"},{"issue":"2","key":"9_CR94","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0006-2952(94)00466-8","volume":"49","author":"MT Runnegar","year":"1995","unstructured":"Runnegar MT, Kong S-M, Zhong Y-Z, Lu SC (1995) Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem Pharmacol 49(2):219\u2013225. https:\/\/doi.org\/10.1016\/S0006-2952(94)00466-8","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"9_CR95","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s11418-017-1144-z","volume":"72","author":"S Sakamoto","year":"2018","unstructured":"Sakamoto S, Putalun W, Vimolmangkang S, Phoolcharoen W, Shoyama Y, Tanaka H, Morimoto S (2018) Enzyme-linked immunosorbent assay for the quantitative\/qualitative analysis of plant secondary metabolites. J Nat Med 72(1):32\u201342. https:\/\/doi.org\/10.1007\/s11418-017-1144-z","journal-title":"J Nat Med"},{"key":"9_CR96","doi-asserted-by":"publisher","unstructured":"Sanseverino I, Ant\u00f3nio DC, Loos R, Lettieri T (2017) Cyanotoxins: methods and approaches for their analysis and detection. JRC Technical Reports EUR-28624 EN. https:\/\/doi.org\/10.2760\/36186","DOI":"10.2760\/36186"},{"key":"9_CR97","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1127\/1864-1318\/2005\/0117-0393","volume":"117","author":"M Santos","year":"2005","unstructured":"Santos M, Pacheco D, Santana F, Muelle H (2005) Cyanobacteria blooms in Sete-Cidades lake (S. Miguel Island - Azores). Algol Stud 117:393\u2013406. https:\/\/doi.org\/10.1127\/1864-1318\/2005\/0117-0393","journal-title":"Algol Stud"},{"issue":"3","key":"9_CR98","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.trac.2011.01.006","volume":"30","author":"N Sanvicens","year":"2011","unstructured":"Sanvicens N, Mannelli I, Salvador JP, Valera E, Marco MP (2011) Biosensors for pharmaceuticals based on novel technology. TrAC Trends Anal Chem 30(3):541\u2013553. https:\/\/doi.org\/10.1016\/j.trac.2011.01.006","journal-title":"TrAC Trends Anal Chem"},{"key":"9_CR99","volume-title":"Electroanalytical methods: guide to experiments and applications","author":"F Scholz","year":"2013","unstructured":"Scholz F (2013) Electroanalytical methods: guide to experiments and applications. Springer, Berlin"},{"issue":"4","key":"9_CR100","doi-asserted-by":"publisher","first-page":"GB4S01","DOI":"10.1029\/2005gb002606","volume":"19","author":"SP Seitzinger","year":"2005","unstructured":"Seitzinger SP, Harrison JA, Dumont E, Beusen AHW, Bouwman AF (2005) Sources and delivery of carbon, nitrogen, and phosphorus to the coastal zone: an overview of global nutrient export from watersheds (NEWS) models and their application. Global Biogeochem Cycles 19(4):GB4S01. https:\/\/doi.org\/10.1029\/2005gb002606","journal-title":"Global Biogeochem Cycles"},{"issue":"2","key":"9_CR101","doi-asserted-by":"publisher","first-page":"66","DOI":"10.5539\/gjhs.v7n2p66","volume":"7","author":"HR Shamsollahi","year":"2014","unstructured":"Shamsollahi HR, Alimohammadi M, Nabizadeh R, Nazmara S, Mahvi AH (2014) Measurement of microcystin\u2014LR in water samples using improved HPLC method. Global J Health Sci 7(2):66\u201370. https:\/\/doi.org\/10.5539\/gjhs.v7n2p66","journal-title":"Global J Health Sci"},{"key":"9_CR102","unstructured":"Shoemaker J, Tettenhorst D, Delacruz A (2015) Method 544: determination of microcystins and nodularin in drinking water by solid phase extraction and liquid chromatography\/tandem mass spectrometry (LC\/MS\/MS). Washington, DC"},{"key":"9_CR103","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/B978-0-323-49780-0.00006-5","volume-title":"Nanoscience and its applications","author":"FR Sim\u00f5es","year":"2017","unstructured":"Sim\u00f5es FR, Xavier MG (2017) Electrochemical sensors. In: Da R\u00f3z AL, Ferreira M, de Lima Leite F, Oliveira ON (eds) Nanoscience and its applications. William Andrew Publishing, Burlington, pp 155\u2013178. https:\/\/doi.org\/10.1016\/B978-0-323-49780-0.00006-5"},{"key":"9_CR104","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/B978-012373944-5.00005-5","volume-title":"Encyclopedia of microbiology","author":"K Sivonen","year":"2009","unstructured":"Sivonen K (2009) Cyanobacterial toxins. In: Schaechter M (ed) Encyclopedia of microbiology, 3rd edn. Academic Press, Oxford, pp 290\u2013307. https:\/\/doi.org\/10.1016\/B978-012373944-5.00005-5","edition":"3"},{"issue":"4","key":"9_CR105","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.tree.2008.11.009","volume":"24","author":"VH Smith","year":"2009","unstructured":"Smith VH, Schindler DW (2009) Eutrophication science: where do we go from here? Trends Ecol Evol 24(4):201\u2013207. https:\/\/doi.org\/10.1016\/j.tree.2008.11.009","journal-title":"Trends Ecol Evol"},{"key":"9_CR106","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/B978-0-12-415759-0.00038-8","volume-title":"Haschek and Rousseaux\u2019s handbook of toxicologic pathology","author":"PF Solter","year":"2013","unstructured":"Solter PF, Beasley VR (2013) Phycotoxins. In: Haschek WM, Rousseaux CG, Wallig MA (eds) Haschek and Rousseaux\u2019s handbook of toxicologic pathology, 3rd edn. Academic Press, Boston, pp 1155\u20131186. https:\/\/doi.org\/10.1016\/B978-0-12-415759-0.00038-8","edition":"3"},{"issue":"1","key":"9_CR107","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jfda.2015.05.001","volume":"24","author":"B Stephen Inbaraj","year":"2016","unstructured":"Stephen Inbaraj B, Chen BH (2016) Nanomaterial-based sensors for detection of foodborne bacterial pathogens and toxins as well as pork adulteration in meat products. J Food Drug Anal 24(1):15\u201328. https:\/\/doi.org\/10.1016\/j.jfda.2015.05.001","journal-title":"J Food Drug Anal"},{"issue":"1","key":"9_CR108","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1749-6632.1986.tb15564.x","volume":"479","author":"G Strichartz","year":"1986","unstructured":"Strichartz G, Rando T, Hall S, Gitschier J, Hall L, Magnani B, Bay CH (1986) On the mechanism by which saxitoxin binds to and blocks sodium channelsa. Ann N Y Acad Sci 479(1):96\u2013112. https:\/\/doi.org\/10.1111\/j.1749-6632.1986.tb15564.x","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"9_CR109","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/00032710903406912","volume":"43","author":"X Sun","year":"2010","unstructured":"Sun X, Shi H, Wang H, Xiao L, Li L (2010) A simple, highly sensitive, and label-free Impedimetric Immunosensor for detection of microcystin-LR in water. Anal Lett 43(4):533\u2013544. https:\/\/doi.org\/10.1080\/00032710903406912","journal-title":"Anal Lett"},{"issue":"1","key":"9_CR110","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00604-012-0912-4","volume":"180","author":"X Sun","year":"2013","unstructured":"Sun X, Guan L, Shi H, Ji J, Zhang Y, Li Z (2013) Determination of microcystin-LR with a glassy carbon impedimetric immunoelectrode modified with an ionic liquid and multiwalled carbon nanotubes. Microchim Acta 180(1):75\u201383. https:\/\/doi.org\/10.1007\/s00604-012-0912-4","journal-title":"Microchim Acta"},{"issue":"15","key":"9_CR111","doi-asserted-by":"publisher","first-page":"9256","DOI":"10.1021\/acs.est.5b01674","volume":"49","author":"F Tan","year":"2015","unstructured":"Tan F, Saucedo NM, Ramnani P, Mulchandani A (2015) Label-free electrical Immunosensor for highly sensitive and specific detection of microcystin-LR in water samples. Environ Sci Technol 49(15):9256\u20139263. https:\/\/doi.org\/10.1021\/acs.est.5b01674","journal-title":"Environ Sci Technol"},{"issue":"6","key":"9_CR112","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1111\/j.1471-4159.1993.tb03519.x","volume":"60","author":"P Thomas","year":"1993","unstructured":"Thomas P, Stephens M, Wilkie G, Amar M, Lunt GG, Whiting P, Gallagher T, Pereira E, Alkondon M, Albuquerque EX, Wonnacott S (1993) (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem 60(6):2308\u20132311. https:\/\/doi.org\/10.1111\/j.1471-4159.1993.tb03519.x","journal-title":"J Neurochem"},{"issue":"3","key":"9_CR113","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00604-011-0557-8","volume":"173","author":"P Tong","year":"2011","unstructured":"Tong P, Tang S, He Y, Shao Y, Zhang L, Chen G (2011) Label-free immunosensing of microcystin-LR using a gold electrode modified with gold nanoparticles. Microchim Acta 173(3):299\u2013305. https:\/\/doi.org\/10.1007\/s00604-011-0557-8","journal-title":"Microchim Acta"},{"issue":"5","key":"9_CR114","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.toxicon.2009.07.012","volume":"55","author":"T Triantis","year":"2010","unstructured":"Triantis T, Tsimeli K, Kaloudis T, Thanassoulias N, Lytras E, Hiskia A (2010) Development of an integrated laboratory system for the monitoring of cyanotoxins in surface and drinking waters. Toxicon 55(5):979\u2013989. https:\/\/doi.org\/10.1016\/j.toxicon.2009.07.012","journal-title":"Toxicon"},{"key":"9_CR501","doi-asserted-by":"publisher","unstructured":"Ugo P, Moretto LM (2017) Electrochemical immunosensors and aptasensors. Chemosensors 5(2):13\u201317. https:\/\/doi.org\/10.3390\/books978-3-03842-407-9","DOI":"10.3390\/books978-3-03842-407-9"},{"key":"9_CR116","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-3-319-19018-1_4","volume-title":"Environmental microbial biotechnology","author":"LSB Upadhyay","year":"2015","unstructured":"Upadhyay LSB, Verma N (2015) Role of biosensors in environmental monitoring. In: Sukla LB, Pradhan N, Panda S, Mishra BK (eds) Environmental microbial biotechnology. Springer, Cham, pp 77\u201390. https:\/\/doi.org\/10.1007\/978-3-319-19018-1_4"},{"key":"9_CR117","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/B978-0-12-800159-2.00031-2","volume-title":"Handbook of toxicology of chemical warfare agents","author":"D van der Merwe","year":"2015","unstructured":"van der Merwe D (2015) Cyanobacterial (blue-green algae) toxins. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents, 2nd edn. Academic Press, Boston, pp 421\u2013429. https:\/\/doi.org\/10.1016\/B978-0-12-800159-2.00031-2","edition":"2"},{"key":"9_CR118","volume-title":"Analytical electrochemistry","author":"J Wang","year":"2004","unstructured":"Wang J (2004) Analytical electrochemistry. Wiley, Hoboken"},{"key":"9_CR119","doi-asserted-by":"publisher","DOI":"10.1002\/0471790303","volume-title":"Analytical electrochemistry","author":"J Wang","year":"2006","unstructured":"Wang J (2006) Analytical electrochemistry. Wiley, Hoboken"},{"issue":"12","key":"9_CR120","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1021\/nl902368r","volume":"9","author":"L Wang","year":"2009","unstructured":"Wang L, Chen W, Xu D, Shim BS, Zhu Y, Sun F, Liu L, Peng C, Jin Z, Xu C, Kotov NA (2009) Simple, rapid, sensitive, and versatile SWNT\u2212paper sensor for environmental toxin detection competitive with ELISA. Nano Lett 9(12):4147\u20134152. https:\/\/doi.org\/10.1021\/nl902368r","journal-title":"Nano Lett"},{"key":"9_CR121","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/B978-0-12-385876-4.00020-7","volume-title":"Freshwater algae of North America","author":"SB Watson","year":"2015","unstructured":"Watson SB, Whitton BA, Higgins SN, Paerl HW, Brooks BW, Wehr JD (2015) Harmful algal blooms. In: Wehr JD, Sheath RG, Kociolek JP (eds) Freshwater algae of North America, 2nd edn. Academic Press, Boston, pp 873\u2013920. https:\/\/doi.org\/10.1016\/B978-0-12-385876-4.00020-7","edition":"2"},{"issue":"21","key":"9_CR122","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1002\/adfm.201100773","volume":"21","author":"Q Wei","year":"2011","unstructured":"Wei Q, Zhao Y, Du B, Wu D, Cai Y, Mao K, Li H, Xu C (2011) Nanoporous PtRu alloy enhanced nonenzymatic Immunosensor for ultrasensitive detection of microcystin-LR. Adv Funct Mater 21(21):4193\u20134198. https:\/\/doi.org\/10.1002\/adfm.201100773","journal-title":"Adv Funct Mater"},{"issue":"1","key":"9_CR123","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.cppeds.2013.10.007","volume":"44","author":"CA Weirich","year":"2014","unstructured":"Weirich CA, Miller TR (2014) Freshwater harmful algal blooms: toxins and Children\u2019s health. Curr Probl Pediatr Adolesc Health Care 44(1):2\u201324. https:\/\/doi.org\/10.1016\/j.cppeds.2013.10.007","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"issue":"18","key":"9_CR124","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1016\/S0043-1354(02)00194-X","volume":"36","author":"M Welker","year":"2002","unstructured":"Welker M, Bickel H, Fastner J (2002) HPLC-PDA detection of cylindrospermopsin\u2014opportunities and limits. Water Res 36(18):4659\u20134663. https:\/\/doi.org\/10.1016\/S0043-1354(02)00194-X","journal-title":"Water Res"},{"issue":"11","key":"9_CR125","doi-asserted-by":"publisher","first-page":"15085","DOI":"10.3390\/s131115085","volume":"13","author":"GM Weller","year":"2013","unstructured":"Weller GM (2013) Immunoassays and biosensors for the detection of Cyanobacterial toxins in water. Sensors 13(11):15085. https:\/\/doi.org\/10.3390\/s131115085","journal-title":"Sensors"},{"key":"9_CR126","volume-title":"Guidelines for drinking-water quality fourth edition","author":"WHO","year":"2011","unstructured":"WHO (2011) Guidelines for drinking-water quality fourth edition, vol 38. WHO, Geneva"},{"issue":"6","key":"9_CR127","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0041-008X(60)90078-8","volume":"2","author":"GS Wiberg","year":"1960","unstructured":"Wiberg GS, Stephenson NR (1960) Toxicologic studies on paralytic shellfish poison. Toxicol Appl Pharmacol 2(6):607\u2013615. https:\/\/doi.org\/10.1016\/0041-008X(60)90078-8","journal-title":"Toxicol Appl Pharmacol"},{"issue":"7","key":"9_CR128","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.3390\/md8072185","volume":"8","author":"M Wiese","year":"2010","unstructured":"Wiese M, D\u2019Agostino PM, Mihali TK, Moffitt MC, Neilan BA (2010) Neurotoxic alkaloids: saxitoxin and its analogs. Mar Drugs 8(7):2185. https:\/\/doi.org\/10.3390\/md8072185","journal-title":"Mar Drugs"},{"issue":"1","key":"9_CR129","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/elan.201200349","volume":"25","author":"JR Windmiller","year":"2013","unstructured":"Windmiller JR, Wang J (2013) Wearable electrochemical sensors and biosensors: a review. Electroanalysis 25(1):29\u201346. https:\/\/doi.org\/10.1002\/elan.201200349","journal-title":"Electroanalysis"},{"key":"9_CR130","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.envint.2016.02.026","volume":"91","author":"R Wood","year":"2016","unstructured":"Wood R (2016) Acute animal and human poisonings from cyanotoxin exposure\u2014a review of the literature. Environ Int 91:276\u2013282. https:\/\/doi.org\/10.1016\/j.envint.2016.02.026","journal-title":"Environ Int"},{"issue":"6","key":"9_CR131","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/bf01637082","volume":"116","author":"S Yoshizawa","year":"1990","unstructured":"Yoshizawa S, Matsushima R, Watanabe MF, Harada K, Ichihara A, Carmichael WW, Fujiki H (1990) Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity. J Cancer Res Clin Oncol 116(6):609\u2013614. https:\/\/doi.org\/10.1007\/bf01637082","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"9_CR132","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1039\/C0CC04198J","volume":"47","author":"J Zhang","year":"2011","unstructured":"Zhang J, Lei J, Pan R, Leng C, Hu Z, Ju H (2011) In situ assembly of gold nanoparticles on nitrogen-doped carbon nanotubes for sensitive immunosensing of microcystin-LR. Chem Commun 47(2):668\u2013670. https:\/\/doi.org\/10.1039\/C0CC04198J","journal-title":"Chem Commun"},{"key":"9_CR133","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.snb.2016.04.145","volume":"233","author":"J Zhang","year":"2016","unstructured":"Zhang J, Sun Y, Dong H, Zhang X, Wang W, Chen Z (2016) An electrochemical non-enzymatic immunosensor for ultrasensitive detection of microcystin-LR using carbon nanofibers as the matrix. Sens Actuators B 233:624\u2013632. https:\/\/doi.org\/10.1016\/j.snb.2016.04.145","journal-title":"Sens Actuators B"},{"key":"9_CR134","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.electacta.2017.03.161","volume":"236","author":"W Zhang","year":"2017","unstructured":"Zhang W, Han C, Jia B, Saint C, Nadagouda M, Falaras P, Sygellou L, Vogiazi V, Dionysiou DD (2017) A 3D graphene-based biosensor as an early microcystin-LR screening tool in sources of drinking water supply. Electrochim Acta 236:319\u2013327. https:\/\/doi.org\/10.1016\/j.electacta.2017.03.161","journal-title":"Electrochim Acta"},{"key":"9_CR135","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.talanta.2018.03.051","volume":"185","author":"K Zhang","year":"2018","unstructured":"Zhang K, Ma H, Yan P, Tong W, Huang X, Chen DDY (2018a) Electrochemical detection of microcystin-LR based on its deleterious effect on DNA. Talanta 185:405\u2013410. https:\/\/doi.org\/10.1016\/j.talanta.2018.03.051","journal-title":"Talanta"},{"issue":"1","key":"9_CR136","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28959-w","volume":"8","author":"W Zhang","year":"2018","unstructured":"Zhang W, Jia B, Furumai H (2018b) Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination. Sci Rep 8(1):10686. https:\/\/doi.org\/10.1038\/s41598-018-28959-w","journal-title":"Sci Rep"},{"key":"9_CR137","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.colsurfb.2012.10.010","volume":"103","author":"H Zhao","year":"2013","unstructured":"Zhao H, Tian J, Quan X (2013) A graphene and multienzyme functionalized carbon nanosphere-based electrochemical immunosensor for microcystin-LR detection. Colloids Surf B Biointerfaces 103:38\u201344. https:\/\/doi.org\/10.1016\/j.colsurfb.2012.10.010","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"16","key":"9_CR138","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1039\/C5AN00704F","volume":"140","author":"Z Zhao","year":"2015","unstructured":"Zhao Z, Chen H, Ma L, Liu D, Wang Z (2015) A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine\u2013graphene nanocomposites. Analyst 140(16):5570\u20135577. https:\/\/doi.org\/10.1039\/C5AN00704F","journal-title":"Analyst"},{"issue":"11","key":"9_CR139","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1039\/C4AN00132J","volume":"139","author":"W Zhou","year":"2014","unstructured":"Zhou W, Jimmy Huang P-J, Ding J, Liu J (2014) Aptamer-based biosensors for biomedical diagnostics. Analyst 139(11):2627\u20132640. https:\/\/doi.org\/10.1039\/C4AN00132J","journal-title":"Analyst"}],"container-title":["Environmental and Microbial Biotechnology","Advances in the Domain of Environmental Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-15-8999-7_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T19:27:20Z","timestamp":1724182040000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-981-15-8999-7_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9789811589980","9789811589997"],"references-count":139,"URL":"https:\/\/doi.org\/10.1007\/978-981-15-8999-7_9","relation":{},"ISSN":["2662-1681","2662-169X"],"issn-type":[{"type":"print","value":"2662-1681"},{"type":"electronic","value":"2662-169X"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"5 January 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}