{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:22:43Z","timestamp":1776021763515,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molec. Gen. Genet."],"published-print":{"date-parts":[[1977,1]]},"DOI":"10.1007\/bf00431594","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T06:53:30Z","timestamp":1100156010000},"page":"289-295","source":"Crossref","is-referenced-by-count":46,"title":["Involvement of IS1 in the dissociation of the r-determinant and RTF components of the plasmid R100.1"],"prefix":"10.1007","volume":"153","author":[{"given":"M.","family":"Chandler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Allet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gallay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Boy de La Tour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Caro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00431594_CR1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/241120a0","volume":"241","author":"B. Allet","year":"1973","unstructured":"Allet, B., Jeppesen, B.G.N., Katagiri, K.J., Delius, H.: Mapping the DNA fragments produced by cleavage of \u03bb DNA with endonuclease RI. Nature (Lond.) 241, 120\u2013123 (1973)","journal-title":"Nature (Lond.)"},{"key":"BF00431594_CR2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/264034a0","volume":"264","author":"B.G. Barrell","year":"1976","unstructured":"Barrell, B.G., Air, G.M., Hutchison, C.A.: Overlapping genes in bacteriophage \u03d5X174. Nature (Lond.) 264, 34\u201341 (1976)","journal-title":"Nature (Lond.)"},{"key":"BF00431594_CR3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0022-2836(72)90559-1","volume":"70","author":"R.E. Bird","year":"1973","unstructured":"Bird, R.E., Louarn, J.M., Martuscelli, J., Caro, L.: Origin and sequence of chromosome replication in Escherichia coli. J. molec. Biol. 70, 549\u2013566 (1973)","journal-title":"J. molec. Biol."},{"key":"BF00431594_CR4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00283357","volume":"108","author":"P. Brachet","year":"1970","unstructured":"Brachet, P., Eisen, H., Rambach, A.: Mutations of coliphage \u03bb affecting the expression of replicative functions O and P. Molec. gen. Genet. 108 266\u2013275 (1970)","journal-title":"Molec. gen. Genet."},{"key":"BF00431594_CR5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0022-2836(76)80138-6","volume":"108","author":"C. Brack","year":"1976","unstructured":"Brack, C., Eberle, H., Bickle, T.A., Yuan, R.: Sites for the restriction endonuclease from Escherichia coli K12 on bacteriophage PM2 DNA. J. molec. Bio. 108, 583\u2013593 (1976)","journal-title":"J. molec. Bio."},{"key":"BF00431594_CR6","unstructured":"Chandler, M., Silver, L., Frey, J., Caro, L.: Suppression of an Escherichia coli dnaA mutation by the integrated R factor R100.1: Generation of small plasmids after integration. J. Bact. in press"},{"key":"BF00431594_CR7","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1073\/pnas.62.4.1159","volume":"62","author":"D.B. Clewell","year":"1969","unstructured":"Clewell, D.B., Helinski, D.R.: Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an open circular DNA form. Proc. nat. Acad. Sci. (Wash.) 62 1159\u20131166 (1969)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00431594_CR8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/263731a0","volume":"263","author":"S.N. Cohen","year":"1976","unstructured":"Cohen, S.N.: Transposable genetic elements and plasmid, evolution. Nature (Lond.) 263, 731\u2013738 (1976)","journal-title":"Nature (Lond.)"},{"key":"BF00431594_CR9","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/2241273a0","volume":"224","author":"S.N. Cohen","year":"1969","unstructured":"Cohen, S.N., Miller, C.: Multiple molecular species of circular R factor DNA isolated from Escherichia coli. Nature (Lond.) 224, 1273\u20131277 (1969)","journal-title":"Nature (Lond.)"},{"key":"BF00431594_CR10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0022-2836(70)90092-6","volume":"50","author":"S.N. Cohen","year":"1970","unstructured":"Cohen, S.N., Miller, C.: Non-chromosomal antibiotic resistance in bacteria II. Molecular nature of R factors isolated from Proteus mirabilis and Escherichia coli. J. molec. Biol. 50, 671\u2013687 (1970a)","journal-title":"J. molec. Biol."},{"key":"BF00431594_CR11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1073\/pnas.67.2.510","volume":"67","author":"S.N. Cohen","year":"1970","unstructured":"Cohen, S.N., Miller, C.: Non-chromosomal antibiotic resistance in bacteria III. Isolation of the discrete transfer unit of the R factor R1. Proc. nat. Acad. Sci. (Wash.) 67 510\u2013516 (1970b)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00431594_CR12","first-page":"56","volume-title":"Microbiology","author":"N. Davidson","year":"1974","unstructured":"Davidson, N., Deonier, R.C., Hu, S., Ohtsubo, E.: Electron microscope heteroduplex studies of sequence, relations among plasmids of Escherichia coli. X. Deoxyribonucleic acid sequence organization of F and of F-Primes, and the sequences involved in Hfr formation, pp. 56\u201365. In: Microbiology D. Schlessinger, ed. Washington, D.C.: American Society for Microbiology 1974"},{"key":"BF00431594_CR13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1266\/jjg.37.66","volume":"37","author":"R. Egawa","year":"1962","unstructured":"Egawa, R., Hirota, Y.: Inhibition of fertility by multiple drugresistance (R) factor in Escherichia coli K12. Jap. J. Genet. 37, 66\u201369 (1962)","journal-title":"Jap. J. Genet."},{"key":"BF00431594_CR14","unstructured":"Hashimoto, H., Rownd, R.: Transposition of the R factor NR1 in Proteus mirabilis: Level of drug resistance of nontransitioned and transitioned cells."},{"key":"BF00431594_CR15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1128\/JB.122.2.764-775.1975","volume":"122","author":"S. Hu","year":"1975","unstructured":"Hu, S., Ohtsubo, E., Davidson, N., Saedler, H.: Electron microscope heteroduplex studies of sequence relationships among bacterial plasmids: identification and mapping of the insertion sequences IS1 and IS2 in F and R plasmids. J. Bact. 122, 764\u2013775 (1975)","journal-title":"J. Bact."},{"key":"BF00431594_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JB.120.1.1-5.1974","volume":"120","author":"J. Louarn","year":"1974","unstructured":"Louarn, J., Funderburg, M., Bird, R.E.: A more precise mapping of the replication origin in Escherichia coli K12. J. Bact. 120 1\u20135 (1974)","journal-title":"J. Bact."},{"key":"BF00431594_CR17","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1073\/pnas.72.3.1184","volume":"72","author":"T. Maniatis","year":"1975","unstructured":"Maniatis, T., Jeffrey, A., Kleid, D.G.: Nucleotide sequence of the rightward operator of phage \u03bb. Proc. nat. Acad. Sci. (Wash.) 72, 1184\u20131188 (1975)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00431594_CR18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1128\/JB.97.1.376-385.1969","volume":"97","author":"T. Nisioka","year":"1969","unstructured":"Nisioka, T., Mitani, M., Clowes, R.: Composite circular forms of R factor deoxyribonucleic acid molecules. J. Bact. 97, 376\u2013385 (1969)","journal-title":"J. Bact."},{"key":"BF00431594_CR19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1128\/JB.103.1.166-177.1970","volume":"130","author":"T. Nisioka","year":"1970","unstructured":"Nisioka, T., Mitani, M., Clowes, R.: Molecular recombination between R factor deoxyribonucleic acid molecules in Escherichia coli host cells. J. Bact. 130, 166\u2013177 (1970)","journal-title":"J. Bact."},{"key":"BF00431594_CR20","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1073\/pnas.73.7.2316","volume":"73","author":"H. Ohtsubo","year":"1976","unstructured":"Ohtsubo, H., Ohtsubo, E., Isolation of inverted repeat sequences including Is1, Is2 and IS3 in Escherichia coli plasmids. Proc. nat. Acad. Sci. (Wash.) 73, 2316\u20132320 (1976)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00431594_CR21","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1128\/JB.123.3.1013-1034.1975","volume":"123","author":"D. Perlman","year":"1975","unstructured":"Perlman, D., Rownd, R.: Transition of R factor NR1 in Proteus mirabilis: Molecular structure and replication of NR1 deoxyribonucleic acid. J. Bact. 123, 1013\u20131034 (1975)","journal-title":"J. Bact."},{"key":"BF00431594_CR22","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1128\/JB.122.2.776-781.1975","volume":"122","author":"K. Ptashne","year":"1975","unstructured":"Ptashne, K., Cohen, S.M.: Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted duplications. J. Bact. 122, 776\u2013781 (1975)","journal-title":"J. Bact."},{"key":"BF00431594_CR23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00332538","volume":"137","author":"H.J. Reif","year":"1975","unstructured":"Reif, H.J., Saedler, H.: IS1 is involved in deletion formation in the gal region of E. coli K12. Molec. gen. Genet. 137, 17\u201328 (1975)","journal-title":"Molec. gen. Genet."},{"key":"BF00431594_CR24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/newbio234040a0","volume":"234","author":"R. Rownd","year":"1971","unstructured":"Rownd, R., Mickel, S.: Dissociation and reassociation of RTF and r-determinants of the R factor NR1 in Proteus mirabilis. Nature (Lond.) 234, 40\u201343 (1971)","journal-title":"Nature (Lond.)"},{"key":"BF00431594_CR25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00269586","volume":"145","author":"F. Schmidt","year":"1976","unstructured":"Schmidt, F., Besemer, J., Starlinger, P.: The isolation of IS1 and IS2 DNA. Molec. gen. Genet. 145 145\u2013154 (1976)","journal-title":"Molec. gen. Genet."},{"key":"BF00431594_CR26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"98","author":"E.M. Southern","year":"1975","unstructured":"Southern, E.M.: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. molec. Biol. 98, 583\u2013517 (1975)","journal-title":"J. molec. Biol."},{"key":"BF00431594_CR27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/JB.127.1.619-636.1976","volume":"127","author":"N. Tanaka","year":"1976","unstructured":"Tanaka, N., Cramer, J.H., Rownd, R.: EcoRI restriction endonuclease map of the composite R plasmid NR1. J. Bact. 127 619\u2013636 (1976)","journal-title":"J. Bact."},{"key":"BF00431594_CR28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-2836(75)90383-6","volume":"91","author":"M. Thomas","year":"1975","unstructured":"Thomas, M., Davis, R.W.: Studies on the cleavage of bacteriophage lambda DNA with EcoRI restriction endonuclease. J. molec. Biol. 91 315\u2013328 (1975)","journal-title":"J. molec. Biol."}],"container-title":["Molecular and General Genetics MGG"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00431594.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00431594\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00431594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00431594.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:22:40Z","timestamp":1585959760000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00431594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["BF00431594"],"URL":"https:\/\/doi.org\/10.1007\/bf00431594","relation":{},"ISSN":["0026-8925","1432-1874"],"issn-type":[{"value":"0026-8925","type":"print"},{"value":"1432-1874","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}