{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:04:08Z","timestamp":1760547848473},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1984,6,1]],"date-time":"1984-06-01T00:00:00Z","timestamp":454896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1984,6]]},"DOI":"10.1007\/bf00464789","type":"journal-article","created":{"date-parts":[[2004,11,14]],"date-time":"2004-11-14T13:35:50Z","timestamp":1100439350000},"page":"249-256","source":"Crossref","is-referenced-by-count":138,"title":["Evaluation of the ?-carboline ZK 93 426 as a benzodiazepine receptor antagonist"],"prefix":"10.1007","volume":"83","author":[{"given":"Leif H.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erling N.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Braestrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tage","family":"Honor\ufffd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Seidelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Schmiechen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/0024-3205(82)90051-0","volume":"31","author":"TE Albertson","year":"1982","unstructured":"Albertson TE, Bowyer JF, Paule MG (1982) Modification of the anticonvulsant efficacy of diazepam by Ro 15-1788 in the kindled amygdaloid seizure model. Life Sci 31:1597?1601","journal-title":"Life Sci"},{"key":"CR2","first-page":"150","volume":"23","author":"P Bernard","year":"1981","unstructured":"Bernard P, Bergen K, Sobiski R, Robson RD (1981) CGS 8216 (2-Phenylpyrazolo[4,3-c]quinoline-3(5H)-one), an orally effective benzodiazepine antagonist. Pharmacologist 23:150","journal-title":"Pharmacologist"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-2999(68)90170-2","volume":"4","author":"JR Boissier","year":"1968","unstructured":"Boissier JR, Simon P, Aron C (1968) A new method for rapid screening of minor tranquillizers in mice. Eur J Pharmacol 4:145?150","journal-title":"Eur J Pharmacol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF00470579","volume":"78","author":"EP Bonetti","year":"1982","unstructured":"Bonetti EP, Pieri L, Cumin R, Schaffner R, Pieri M, Gamzu ER, M\u00fcller RKM, Haefely W (1982) Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects. Psychopharmacology 78:8?18","journal-title":"Psychopharmacology"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.6281892","volume":"216","author":"C Braestrup","year":"1982","unstructured":"Braestrup C, Schmiechen R, Neff G, Nielsen M, Petersen EN (1982) Interaction of convulsive ligands with benzodiazepine receptors. Science 216:1241?1243","journal-title":"Science"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1471-4159.1983.tb04763.x","volume":"41","author":"C Braestrup","year":"1983","unstructured":"Braestrup C, Nielsen M, Honor\u00e9 T (1983) Binding of [3H]-DMCM, a convulsive benzodiazepine ligand to rat brain membranes. Preliminary studies. J Neurochem 41:454?464","journal-title":"J Neurochem"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-2999(78)90330-8","volume":"48","author":"RSL Chang","year":"1978","unstructured":"Chang RSL, Snyder SH (1978) Benzodiazepine receptors: Labelling in intact animals with [3H]flunitrazepam. Eur J Pharmacol 48:213?218","journal-title":"Eur J Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4684-3090-5_6","volume-title":"Discriminative stimulus properties of drugs","author":"FC Colpaert","year":"1977","unstructured":"Colpaert FC (1977) Discriminative stimulus properties of benzodiazepines and barbiturates. In: Lal H (ed) Discriminative stimulus properties of drugs. Plenum, New York, pp 93?106"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0028-3908(82)90217-9","volume":"21","author":"MG Corda","year":"1982","unstructured":"Corda MG, Costa E, Guidotti A (1982) Specific proconvulsant action of an imidazobenzodiazepine (Ro 15-1788) on isoniazid convulsions. Neuropharmacology 21:91?94","journal-title":"Neuropharmacology"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1073\/pnas.80.7.2072","volume":"80","author":"MG Corda","year":"1983","unstructured":"Corda MG, Blaker WD, Mendelson WB, Guidotti A, Costa E (1983) ?-Carbolines enhance shock-induced suppression of drinking in rats. Proc Natl Acad Sci USA 80:2072?2076","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0024-3205(82)90573-2","volume":"30","author":"AJ Czernik","year":"1982","unstructured":"Czernik AJ, Petrack B, Kalinsky HJ, Psychoyos S, Cash WD, Tsai C, Rinehart RK, Granat FR, Lovell RA, Brundish DE, Wade R (1982) CGS 8216: Receptor binding characteristics of a potent benzodiazepine antagonist. Life Sci 30:363?372","journal-title":"Life Sci"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0014-2999(82)90355-7","volume":"81","author":"R Dantzer","year":"1982","unstructured":"Dantzer R, Perio A (1982) Behavioural evidence for partial agonist properties of Ro 15-1788, a benzodiazepine receptor antagonist. Eur J Pharmacol 81:655?658","journal-title":"Eur J Pharmacol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/01621459.1948.10483254","volume":"43","author":"WJ Dixon","year":"1948","unstructured":"Dixon WJ, Mood AM (1948) A method for obtaining and analysing sensitivity data. J Am Statist Assoc 43:109?112","journal-title":"J Am Statist Assoc"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0140-6736(83)90076-4","volume":"II","author":"R Dorow","year":"1983","unstructured":"Dorow R, Horowski R, Paschelke G, Amin M, Braestrup C (1983) Severe anxiety induced by FG 7142, a ?-carboline ligand for benzodiazepine receptors. Lancet II:98","journal-title":"Lancet"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0014-2999(81)90375-7","volume":"70","author":"FJ Ehlert","year":"1981","unstructured":"Ehlert FJ, Roeske WR, Braestrup C, Yamamura SH, Yamamura HI (1981) ?-Aminobutyric acid regulation of the benzodiazepine receptor: Biochemical evidence for pharmacologically different effects of benzodiazepines and propyl ?-carboline-3-carboxylate. Eur J Pharmacol 70:593?596","journal-title":"Eur J Pharmacol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0091-3057(83)90361-1","volume":"18","author":"SE File","year":"1983","unstructured":"File SE, Lister RG (1983) Quinolines and anxiety: Anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084, Pharmacol. Biochem Behav 18:185?188","journal-title":"Pharmacol. Biochem Behav"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0028-3908(82)90118-6","volume":"21","author":"SE File","year":"1982","unstructured":"File SE, Lister RG, Nutt DJ (1982) The anxiogenic action of benzodiazepine antagonists. Neuropharmacology 21:1033?1037","journal-title":"Neuropharmacology"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(84)90321-2","volume":"100","author":"T Honor\u00e9","year":"1984","unstructured":"Honor\u00e9 T, Nielsen M, Braestrup C (1984) Barbiturate shift as a tool for determination of efficacy of benzodiazepine receptor ligands. Eur J Pharmacol 100:101?108","journal-title":"Eur J Pharmacol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/290514a0","volume":"290","author":"W Hunkeler","year":"1981","unstructured":"Hunkeler W, M\u00f6hler H, Pieri L, Polc P, Bonetti EP, Cumin R, Schaffner R, Haefely W (1981) Selective antagonists of benzodiazepines. Nature 290:514?516","journal-title":"Nature"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0024-3205(83)80014-9","volume":"33","author":"LH Jensen","year":"1983","unstructured":"Jensen LH, Petersen EN, Braestrup C (1983) Audiogenic seizures in DBA\/2 mice discriminate sensitively between low efficacy benzodiazepine receptor agonists and inverse agonists. Life Sci 33:393?399","journal-title":"Life Sci"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF01252804","volume":"58","author":"LH Jensen","year":"1983","unstructured":"Jensen LH, Petersen EN (1983) Bidirectional effects of benzodiazepine receptor ligands against picrotoxin-and pentylenetetrazol-induced seizures. J Neural Transm 58:183?191","journal-title":"J Neural Transm"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3940(82)90055-6","volume":"31","author":"M Karobath","year":"1982","unstructured":"Karobath M, Supavilai P (1982) Distinction of benzodiazepine agonists from antagonists by photoaffinity labelling of benzodiazepine receptors in vitro. Neurosci Lett 31:65?69","journal-title":"Neurosci Lett"},{"key":"CR23","first-page":"99","volume":"96","author":"JT Litchfield","year":"1948","unstructured":"Litchfield JT, Wilcoxon F (1948) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96:99?103","journal-title":"J Pharmacol Exp Ther"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/0024-3205(83)90422-8","volume":"32","author":"WB Mendelson","year":"1983","unstructured":"Mendelson WB, Davis T, Paul SM, Skolnick P (1983) Do benzodiazepine receptors mediate the anticonflict action of pentobarbital? Life Sci 32:2241?2246","journal-title":"Life Sci"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/295436a0","volume":"295","author":"DJ Nutt","year":"1982","unstructured":"Nutt DJ, Cowen PJ, Little HJ (1982) Unusual interactions of benzodiazepine receptor antagonist. Nature 295:436?438","journal-title":"Nature"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0014-2999(80)90538-5","volume":"68","author":"NR Oakley","year":"1980","unstructured":"Oakley NR, Jones BJ (1980) The proconvulsant and diazepamreversing effects of ethyl-?-carboline-3-carboxylate. Eur J Pharmacol 68:381?382","journal-title":"Eur J Pharmacol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-2999(82)90517-9","volume":"82","author":"EN Petersen","year":"1982","unstructured":"Petersen EN, Paschelke G, Kehr W, Nielsen M, Braestrup C (1982) Does the reversal of the anticonflict effect of phenobarbital by ?-CCE and FG 7142 indicate benzodiazepine receptor mediated anxiogenic properties? Eur J Pharmacol 82:217?221","journal-title":"Eur J Pharmacol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-2999(83)90448-X","volume":"94","author":"EN Petersen","year":"1983","unstructured":"Petersen EN (1983) DMCM: A potent convulsive benzodiazepine receptor ligand. Eur J Pharmacol 94:117?124","journal-title":"Eur J Pharmacol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/BF00498510","volume":"321","author":"P Polc","year":"1982","unstructured":"Polc P, Bonetti EP, Schaffner R, Haefely W (1982) A three-state model of the benzodiazepine-receptor explains the interaction between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone. Arch Pharmacol 321:260?264","journal-title":"Arch Pharmacol"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0091-3057(82)90304-5","volume":"17","author":"M Schweri","year":"1982","unstructured":"Schweri M, Cain M, Cook J, Paul S, Skolnick P (1982) Blockade of 3-carbomethoxy-?-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. Pharmacol Biochem Behav 17:457?463","journal-title":"Pharmacol Biochem Behav"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00427516","volume":"64","author":"D Shearman","year":"1979","unstructured":"Shearman D, Lal H (1979) Discriminative stimulus properties of pentylenetetrazol and bemegride: Some generalization and antagonism tests. Psychopharmacology 64:315?319","journal-title":"Psychopharmacology"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0014-2999(82)90428-9","volume":"85","author":"A Valin","year":"1982","unstructured":"Valin A, Dodd RH, Liston DR, Potier P, Rossier J (1982) Methyl-?-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-?-carboline. Eur J Pharmacol 85:93?97","journal-title":"Eur J Pharmacol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00464789.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00464789\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00464789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T02:48:44Z","timestamp":1554346124000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00464789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,6]]}},"alternative-id":["BF00464789"],"URL":"https:\/\/doi.org\/10.1007\/bf00464789","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,6]]}}}