{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T06:21:46Z","timestamp":1750486906580},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1982,8,1]],"date-time":"1982-08-01T00:00:00Z","timestamp":397008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1982,8]]},"DOI":"10.1007\/bf00506306","type":"journal-article","created":{"date-parts":[[2004,11,22]],"date-time":"2004-11-22T14:53:34Z","timestamp":1101135214000},"page":"90-96","source":"Crossref","is-referenced-by-count":62,"title":["A study of the sensitivity of rat brain alpha2-adrenoceptors during chronic antidepressant treatments"],"prefix":"10.1007","volume":"320","author":[{"given":"Michael F.","family":"Sugrue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF00506488","volume":"292","author":"NE And\ufffdn","year":"1976","unstructured":"And\ufffdn NE, Grabowska M, Str\ufffdmbom U (1976) Different alpha-adrenoceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents. Naunyn-Schmiedeberg's Arch Pharmacol 292:43?52","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00003495-197816040-00001","volume":"16","author":"RN Brogden","year":"1978","unstructured":"Brogden RN, Heel RC, Speight TM, Avery GS (1978) Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs 16:273?301","journal-title":"Drugs"},{"key":"CR3","first-page":"568","volume":"12","author":"DB Bylund","year":"1976","unstructured":"Bylund DB, Snyder SH (1976) Beta-adrenergic receptor binding in membrane preparations from mammalian brain. Mol Pharmacol 12:568?580","journal-title":"Mol Pharmacol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-2999(69)90114-9","volume":"5","author":"A Carlsson","year":"1969","unstructured":"Carlsson A, Corrodi H, Fuxe K, H\ufffdkfelt T (1969) Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4-alpha-dimethyl-meta-tyramine. Eur J Pharmacol 5:367?373","journal-title":"Eur J Pharmacol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0014-2999(81)90176-X","volume":"70","author":"F Cerrito","year":"1981","unstructured":"Cerrito F, Raiteri M (1981) Supersensitivity of central noradrenergic presynaptic autoreceptors following chronic treatment with the antidepressant mianserin. Eur J Pharmacol 70:425?426","journal-title":"Eur J Pharmacol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Y Cheng","year":"1973","unstructured":"Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction. Biochem Pharmacol 22:3099?3108","journal-title":"Biochem Pharmacol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0028-3908(80)90197-5","volume":"19","author":"S Clements-Jewery","year":"1980","unstructured":"Clements-Jewery S, Robson PA, Chidley LJ (1980) Biochemical investigations into the mode of action of trazodone. Neuropharmacology 19:1165?1173","journal-title":"Neuropharmacology"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0028-3908(82)90091-0","volume":"21","author":"RM Cohen","year":"1982","unstructured":"Cohen RM, Campbell IC, Dauphin MD, Tallman JF, Murphy DL (1982) Changes in alpha and beta-receptor densities in rat brain as a result of treatment with monoamine oxidase inhibiting (MAOI) antidepressants. Neuropharmacology 21:293?298","journal-title":"Neuropharmacology"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.211589","volume":"202","author":"FT Crews","year":"1978","unstructured":"Crews FT, Smith CB (1978) Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment. Science 202:322?324","journal-title":"Science"},{"key":"CR10","first-page":"143","volume":"215","author":"FT Crews","year":"1980","unstructured":"Crews FT, Smith CB (1980) Potentiation of responses to adrenergic nerve stimulation in isolated rat atria during chronic tricyclic antidepressant administration. J Pharmacol Exp Ther 215:143?149","journal-title":"J Pharmacol Exp Ther"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00498452","volume":"307","author":"A Delini-Stula","year":"1979","unstructured":"Delini-Stula A, Baumann P, B\ufffdch O (1979) Depression of exploratory activity by clonidine in rats as a model for the detection of relative pre- and postsynaptic central noradrenergic receptor selectivity of alpha-adrenolytic drugs. Naunyn-Schmiedeberg's Arch Pharmacol 307:115?122","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/0006-2952(79)90611-7","volume":"28","author":"EM DeMet","year":"1979","unstructured":"DeMet EM, Halaris AE (1979) Origin and distribution of 3-methoxy-4-hydroxyphenylglycol in body fluids. Biochem Pharmacol 28:3043?3050","journal-title":"Biochem Pharmacol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1476-5381.1979.tb16116.x","volume":"67","author":"GM Drew","year":"1979","unstructured":"Drew GM, Gower AJ, Marriott AS (1979) Alpha2-adrenoceptors mediate clonidine-induced sedation in the rat. Br J Pharmacol 67:133?141","journal-title":"Br J Pharmacol"},{"key":"CR14","first-page":"311","volume":"206","author":"A Frazer","year":"1978","unstructured":"Frazer A, Hess ME, Mendels J, Gable B, Kunkel E, Bender A (1978) Influence of acute and chronic treatment with demethylimipramine on catecholamine effects in the rat. J Pharmacol Exp Ther 206:311?319","journal-title":"J Pharmacol Exp Ther"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0028-3908(79)90020-0","volume":"18","author":"RW Fuller","year":"1979","unstructured":"Fuller RW, Snoddy HD, Perry KW (1979) Nisoxetine antagonism of norepinephrine depletion in brain and heart after alpha-methyl-m-tyrosine administration. Neuropharmacology 18:767?770","journal-title":"Neuropharmacology"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00504525","volume":"314","author":"H Glossman","year":"1980","unstructured":"Glossman H, Hornung R (1980) Alpha2 adrenoceptors in rat brain. The divalent cation site. Naunyn-Schmiedeberg's Arch Pharmacol 314:101?109","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00411167","volume":"15","author":"MI Gluckman","year":"1969","unstructured":"Gluckman MI, Baum T (1969) The phramacology of iprindole, a new antidepressant. Psychopharmacologia (Berl) 15:169?185","journal-title":"Psychopharmacologia (Berl)"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1016\/0024-3205(81)90100-4","volume":"28","author":"Z G\ufffdrka","year":"1981","unstructured":"G\ufffdrka Z, Zacny E (1981) The effect of single and chronic administration of imipramine on clonidine-induced hypothermia in the rat. Life Sci 28:2847?2854","journal-title":"Life Sci"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-2999(81)90549-5","volume":"75","author":"DJ Heal","year":"1981","unstructured":"Heal DJ, Akagi H, Bowdler JM, Green AR (1981) Repeated electroconvulsive shock attenuates clonidine-induced hypoactivity in rodents. Eur J Pharmacol 75:231?237","journal-title":"Eur J Pharmacol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-2999(80)90019-9","volume":"67","author":"RW Johnson","year":"1980","unstructured":"Johnson RW, Reisine T, Spotnitz S, Wiech N, Ursillo R, Yamamura HI (1980) Effects of desipramine and yohimbine on alpha2- and beta-adrenoceptor sensitivity. Eur J Pharmacol 67:123?127","journal-title":"Eur J Pharmacol"},{"key":"CR21","series-title":"Advances in the biosciences","volume-title":"Presynaptic receptors","author":"SZ Langer","year":"1979","unstructured":"Langer SZ, Starke K, Dubocovich ML (eds) (1979) Presynaptic receptors. Advances in the biosciences, vol 18. Pergamon Press, Oxford"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1192\/bjp.136.4.354","volume":"136","author":"Y Lecrubier","year":"1980","unstructured":"Lecrubier Y, Puech AJ, Jouvent R, Simon P, Widlocher D (1980) A beta-adrenergic stimulant (salbutamol) versus clomipramine in depression: a controlled study. Br J Psychiat 136:354?358","journal-title":"Br J Psychiat"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265?275","journal-title":"J Biol Chem"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1126\/science.6101510","volume":"107","author":"A Maggi","year":"1980","unstructured":"Maggi A, U'Prichard DC, Enna SJ (1980) Beta-adrenergic regulation of alpha2-adrenergic receptors in the central nervous system. Science 107:645?647","journal-title":"Science"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0014-2999(80)90126-0","volume":"61","author":"BA McMillen","year":"1980","unstructured":"McMillen BA, Warnack W, German DC, Shore PA (1980) Effects of chronic desipramine treatment on rat brain noradrenergic responses to alpha-adrenergic drugs. Eur J Pharmacol 61:239?246","journal-title":"Eur J Pharmacol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1476-5381.1972.tb08099.x","volume":"45","author":"JL Meek","year":"1972","unstructured":"Meek JL, Neff NH (1972) Fluorometric estimation of 4-hydroxy-3-methoxyphenylethyleneglycol sulphate in brain. Br J Pharmacol 45:435?441","journal-title":"Br J Pharmacol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0091-3057(80)90457-8","volume":"12","author":"LR Meyerson","year":"1980","unstructured":"Meyerson LR, Ong HH, Martin LL, Ellis DB (1980) Effect of antidepressant agents on beta-adrenergic receptor and neurotransmitter regulatory systems. Pharmacol Biochem Behav 12:943?948","journal-title":"Pharmacol Biochem Behav"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(79)90246-2","volume":"60","author":"R Mishra","year":"1979","unstructured":"Mishra R, Janowsky A, Sulser F (1979) Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: effects of nisoxetine versus fluoxetine. Eur J Pharmacol 60:379?382","journal-title":"Eur J Pharmacol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/0028-3908(80)90009-X","volume":"19","author":"R Mishra","year":"1980","unstructured":"Mishra R, Janowsky A, Sulser F (1980) Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding. Neuropharmacology 19:983?987","journal-title":"Neuropharmacology"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/BF00507225","volume":"316","author":"MJ Morris","year":"1981","unstructured":"Morris MJ, Elghozi JL, Dausse JP, Meyer P (1981) Alpha1- and alpha2-adrenoceptors in rat cerebral cortex: effect of frontal lobotomy. Naunyn-Schmiedeberg's Arch Pharmacol 316:42?44","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.2042-7158.1977.tb11255.x","volume":"20","author":"A Nagy","year":"1977","unstructured":"Nagy A (1977) Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats. J Pharm Pharmacol 20:104?107","journal-title":"J Pharm Pharmacol"},{"key":"CR32","first-page":"582","volume":"215","author":"SJ Peroutka","year":"1980","unstructured":"Peroutka SJ, Snyder SH (1980) Regulation of serotonin2 (5-HT2) receptors labeled with (3H) spiroperidol by chronic treatment with the antidepressant amitriptyline. J Pharmacol Exp Ther 215:582?587","journal-title":"J Pharmacol Exp Ther"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0014-2999(81)90123-0","volume":"76","author":"BD Perry","year":"1981","unstructured":"Perry BD, U'Prichard DC (1981) (3H) Rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha2-adrenergic receptors. Eur J Pharmacol 76:461?464","journal-title":"Eur J Pharmacol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0006-8993(80)90060-8","volume":"188","author":"TD Reisine","year":"1980","unstructured":"Reisine TD, U'Prichard DC, Wiech NL, Ursillo RC, Yamamura HI (1980) Effects of combined administration of amphetamine and iprindole on brain adrenergic receptors. Brain Res 188:587?592","journal-title":"Brain Res"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","volume":"51","author":"G Scatchard","year":"1949","unstructured":"Scatchard G (1949) The attractions of proteins for small moledcules and ions. Ann NY Acad Sci 51:660?672","journal-title":"Ann NY Acad Sci"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0006-8993(81)90919-7","volume":"210","author":"CB Smith","year":"1981","unstructured":"Smith CB, Garcia-Sevilla JA, Hollingsworth PJ (1981) Alpha2-adrenoceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment. Brain Res 210:413?418","journal-title":"Brain Res"},{"key":"CR37","first-page":"404","volume-title":"Biometry: the principles and practice of statistics in biological research","author":"RR Sokal","year":"1969","unstructured":"Sokal RR, Rohlf FJ (1969) Biometry: the principles and practice of statistics in biological research. Freeman and Co, San Francisco, pp 404?493"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/0024-3205(80)90431-2","volume":"27","author":"C Spyraki","year":"1980","unstructured":"Spyraki C, Fibiger HC (1980) Functional evidence for subsensitivity of noradrenergic alpha2-receptors after chronic desipramine treatment. Life Sci 27:1863?1867","journal-title":"Life Sci"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-2999(80)90537-3","volume":"68","author":"MF Sugrue","year":"1980","unstructured":"Sugrue MF (1980) The inability of chronic mianserin to block central alpha2-adrenoceptors. Eur J Pharmacol 68:377?380","journal-title":"Eur J Pharmacol"},{"key":"CR40","first-page":"13","volume-title":"Antidepressants: neurochemical, behavioral and clinical perspectives","author":"MF Sugrue","year":"1981","unstructured":"Sugrue MF (1981a) Chronic antidepressant administration and adaptive changes in central monoaminergic systems. In: Enna SJ, Malick JB, Richelson F (eds) Antidepressants: neurochemical, behavioral and clinical perspectives. Raven Press, New York, pp 13?30"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0163-7258(81)90001-2","volume":"13","author":"MF Sugrue","year":"1981","unstructured":"Sugrue MF (1981b) Current concepts on the mechanisms of action of antidepressant drugs. Pharmacol Ther 13:219?247","journal-title":"Pharmacol Ther"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0024-3205(81)90082-5","volume":"28","author":"MF Sugrue","year":"1981","unstructured":"Sugrue MF (1981c) Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethyleneglycol sulphate content. Life Sci 28:377?384","journal-title":"Life Sci"},{"key":"CR43","first-page":"760P","volume":"74","author":"MF Sugrue","year":"1981","unstructured":"Sugrue MF (1981d) Effect of chronic antidepressant administration on rat frontal cortex alpha2- and beta-adrenoceptor binding. Br J Pharmacol 74:760P-761P","journal-title":"Br J Pharmacol"},{"key":"CR44","first-page":"55","volume-title":"Typical and atypical antidepressants","author":"MF Sugrue","year":"1982","unstructured":"Sugrue MF (1982) Effect of chronic antidepressants on rat brain alpha2-adrenoceptor sensitivity. In: Racagni G, Costa E (eds) Typical and atypical antidepressants. Raven Press, New York, pp 55?62"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0006-2952(78)90226-5","volume":"27","author":"F Sulser","year":"1978","unstructured":"Sulser F, Vetulani J, Mobley PL (1978) Mode of action of antidepressant drugs. Biochem Pharmacol 27:257?261","journal-title":"Biochem Pharmacol"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.213833","volume":"202","author":"TH Svensson","year":"1978","unstructured":"Svensson TH, Usdin T (1978) Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation. Science 202:1089?1091","journal-title":"Science"},{"key":"CR47","first-page":"47","volume":"16","author":"DC U'Prichard","year":"1979","unstructured":"U'Prichard DC, Bechtel WD, Rouot BM, Snyder SH (1979) Multiple apparent alpha-noradrenergic receptor binding sites in rat brain: effect of 6-hydroxydopamine. Mol Pharmacol 16:47?60","journal-title":"Mol Pharmacol"},{"key":"CR48","unstructured":"Vetulani J, Pilc A, Golembiowska-Nikitin K (1980) The effect of chronic imipramine treatment of rats on 3H-clonidine binding in the brain. Prog Neuro-Psychopharmacology, Suppl 349"},{"key":"CR49","first-page":"446","volume":"207","author":"BB Wolfe","year":"1978","unstructured":"Wolfe BB, Harden TK, Sporn JR, Molinoff PB (1978) Presynaptic modulation of beta-adrenergic receptors in rat cerebral cortex after treatment with antidepressants. J Pharmacol Exp Ther 207:446?457","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00506306.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00506306\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00506306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T17:55:09Z","timestamp":1705341309000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00506306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["BF00506306"],"URL":"https:\/\/doi.org\/10.1007\/bf00506306","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]}}}