{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:12:00Z","timestamp":1699794720811},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1955,4,1]],"date-time":"1955-04-01T00:00:00Z","timestamp":-465609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experientia"],"published-print":{"date-parts":[[1955,4]]},"DOI":"10.1007\/bf02158478","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T08:18:40Z","timestamp":1126858720000},"page":"152-154","source":"Crossref","is-referenced-by-count":4,"title":["Mitotic frequency in normal and regenerating tail tips ofRana pipiens embryos"],"prefix":"10.1007","volume":"11","author":[{"given":"Marie","family":"DiBerardino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02158478_CR1","first-page":"715","volume":"79","author":"G. Fankhauser","year":"1938","unstructured":"G. Fankhauser, Proc. Amer. Phil. Soc.79, 715 (1938); Quart. Rev. Biol.20, 20 (1945).","journal-title":"Proc. Amer. Phil. Soc."},{"key":"BF02158478_CR2","first-page":"428","volume":"93","author":"D. P. Costello","year":"1949","unstructured":"D. P. Costello andC. Henley, Proc. Amer. Phil. Soc.93, 428 (1949).","journal-title":"Proc. Amer. Phil. Soc."},{"key":"BF02158478_CR3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jmor.1050890107","volume":"89","author":"C. Henley","year":"1951","unstructured":"C. Henley andD. P. Costello, J. Morph.89, 91 (1951).","journal-title":"J. Morph."},{"key":"BF02158478_CR4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3109\/10520295009110973","volume":"25","author":"H. P. Ting","year":"1950","unstructured":"H. P. Ting, Stain Techn.25, 127 (1950).","journal-title":"Stain Techn."},{"key":"BF02158478_CR5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ar.1090780202","volume":"78","author":"W. Shumway","year":"1940","unstructured":"W. Shumway, Anat. Rec.78, 139 (1940).","journal-title":"Anat. Rec."},{"key":"BF02158478_CR6","first-page":"102","volume-title":"Experimental Embryology","author":"R. Rugh","year":"1948","unstructured":"R. Rugh,Experimental Embryology (Burgess Publishing Co., Minneapolis, Minn., 1948), p. 102."},{"key":"BF02158478_CR7","first-page":"428","volume":"93","author":"D. P. Costello","year":"1949","unstructured":"Although the embryos were exposed to M.S. 222 for only a very brief period, and developed normally thereafter, it is still necessary to consider the possibility of there being effects of the chemical on mitosis. According toD. P. Costello andC. Henley [Proc. Amer. Phil. Soc.93, 428 (1949)], M.S. 222 used as an anaesthetic in a concentration of 1:2000 (0.05%) has no noticeable effect on mitosis in regenerating tail tips of Triturus torosus larvae. Also, in this laboratory the anaesthetic has been used on young tadpoles without detectable effect on the mitotic mechanism during subsequent regeneration. Finally, it may be noted from data presented in this paper that the mitotic frequency peak in regenerating tips occurs at stage 25, whether the anaesthesia and amputation occurred at stage 18 or at stage 19. If there were a significant inhibiting effect of the chemical on mitosis one would expect embryos exposed to it at stage 19 to exhibit the peak at a later stage than those exposed at stage 18. Considering these points, we think it unlikely that the M.S. 222, as used in these experiments, has significant effects on mitosis.","journal-title":"Proc. Amer. Phil. 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