{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:19:58Z","timestamp":1773026398825,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1007\/bf02789090","type":"journal-article","created":{"date-parts":[[2007,12,22]],"date-time":"2007-12-22T10:49:24Z","timestamp":1198320564000},"page":"303-311","source":"Crossref","is-referenced-by-count":123,"title":["Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob\/ob) mice"],"prefix":"10.1007","volume":"61","author":[{"given":"Ming-Der","family":"Chen","sequence":"first","affiliation":[]},{"given":"Shy-Jane","family":"Liou","sequence":"additional","affiliation":[]},{"given":"Pi-Yao","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Vivian C.","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Paul S.","family":"Alexander","sequence":"additional","affiliation":[]},{"given":"Wen-Han","family":"Lin","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF02789090_CR1","first-page":"465","volume":"13","author":"P. J. Collipp","year":"1984","unstructured":"P. J. Collipp, New development in medical therapy of obesity: thyroid and zinc,Pediatr. Ann. 13, 465\u2013472 (1984).","journal-title":"Pediatr. Ann."},{"key":"BF02789090_CR2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/ajcn\/48.5.1307","volume":"48","author":"M. D. Chen","year":"1988","unstructured":"M. D. Chen, P. Y. Lin, W. H. Lin, and V. Cheng, Zinc in hair and serum of obese individuals in Taiwan,Am. J. Clin. Nutr. 48, 1307\u20131309 (1988).","journal-title":"Am. J. Clin. Nutr."},{"key":"BF02789090_CR3","first-page":"177","volume":"24","author":"G. Di-Martino","year":"1993","unstructured":"G. Di-Martino, M. G. Matera, B. De-Martino, C. Vacca, S. Di-Martino, and F. Rossi, Relationship between zinc and obesity,J. Med. 24, 177\u2013183 (1993).","journal-title":"J. Med."},{"key":"BF02789090_CR4","first-page":"210","volume":"48","author":"M. D. Chen","year":"1991","unstructured":"M. D. Chen, W. H. Lin, and P. Y. Lin, Zinc sulfate and thyroxine treatment on the obese patients,Chin. Med. J. 48, 210\u2013216 (1991).","journal-title":"Chin. Med. J."},{"key":"BF02789090_CR5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2337\/diab.34.2.179","volume":"34","author":"N. Begin-Heick","year":"1985","unstructured":"N. Begin-Heick, M. Daple-Scott, J. Rowe, and H. M. C. Heick, Zinc supplementation attenuates insulin secretory activity in pancreatic islet of the ob \/ob mouse,Diabetes 34, 179\u2013184 (1985).","journal-title":"Diabetes"},{"key":"BF02789090_CR6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/jn\/117.5.886","volume":"117","author":"M. L. Kennedy","year":"1987","unstructured":"M. L. Kennedy and M. L. Failla, Zinc metabolism in genetically obese (ob\/ob) mice,J. Nutr. 117, 886\u2013893 (1987).","journal-title":"J. Nutr."},{"key":"BF02789090_CR7","first-page":"s27","volume":"91","author":"W. H. Lin","year":"1992","unstructured":"W. H. Lin, M. D. Chen, and P. Y. Lin, Investigation of the profile of selected trace metals in genetically obese (ob\/ob) and lean (+\/?) mice,J. Formosan. Med. Assoc. 91, s27-s33 (1992).","journal-title":"J. Formosan. Med. Assoc."},{"key":"BF02789090_CR8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02789454","volume":"52","author":"M. D. Chen","year":"1996","unstructured":"M. D. Chen, P. Y. Lin, V. Cheng, and W. H. Lin, Zinc supplementation aggravates body fat accumulation in genetically obese (ob\/ob) mice and dietary-obese mice,Biol. Trace. Elem. Res. 52, 125\u2013132 (1996).","journal-title":"Biol. Trace. Elem. Res."},{"key":"BF02789090_CR9","first-page":"653","volume":"42","author":"D. A. Leaf","year":"1990","unstructured":"D. A. Leaf, Overweight: assessment and management issues,Am. Fam. Physician. 42, 653\u2013660 (1990).","journal-title":"Am. Fam. Physician."},{"key":"BF02789090_CR10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02790141","volume":"47","author":"J. F. Burn","year":"1995","unstructured":"J. F. Burn, R. Guintrand-Hugret, C. Fons, J. Carvajal, C. Fedou, M. Fussellier, L. Bardet, and A. Orsetti, Effects of oral zinc gluconate on glucose effectiveness and insulin sensitivity in humans,Biol. Trace. Elem. Res. 47, 385\u2013391 (1995).","journal-title":"Biol. Trace. Elem. Res."},{"key":"BF02789090_CR11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0306-9877(94)90029-9","volume":"42","author":"J. E. Sprietsma","year":"1994","unstructured":"J. E. Sprietsma and G. E. Schuitemaker, Diabetes can be prevented by reducing insulin production,Med. Hypotheses 42, 15\u201323 (1994).","journal-title":"Med. Hypotheses"},{"key":"BF02789090_CR12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02789121","volume":"3","author":"H. P. Roth","year":"1981","unstructured":"H. P. Roth and M. Kirchgessner, Zinc and insulin metabolism,Biol. Trace. Elem. Res. 3, 13\u201332 (1981).","journal-title":"Biol. Trace. Elem. Res."},{"key":"BF02789090_CR13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02784615","volume":"32","author":"P. Faure","year":"1992","unstructured":"P. Faure, A. Roussel, C. Coudray, M. J. Richard, S. Halimi, and A. Favier, Zinc and insulin sensitivity,Biol. Trace. Elem. Res. 32, 305\u2013310 (1992).","journal-title":"Biol. Trace. Elem. Res."},{"key":"BF02789090_CR14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2337\/diab.29.8.665","volume":"29","author":"L. Coulston","year":"1980","unstructured":"L. Coulston and P. Nandona, Insulin-like effect of zinc on adipocytes,Diabetes 29, 665\u2013667 (1980).","journal-title":"Diabetes"},{"key":"BF02789090_CR15","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1016\/S0021-9258(18)34730-6","volume":"257","author":"J. M. May","year":"1982","unstructured":"J. M. May and C. S. Contoreggi, The mechanism of the insulin-like effects of ionic zinc,J. Biol. Chem. 257, 4362\u20131368 (1982).","journal-title":"J. Biol. Chem."},{"key":"BF02789090_CR16","doi-asserted-by":"crossref","first-page":"16,118","DOI":"10.1016\/S0021-9258(18)71594-9","volume":"264","author":"O. Ezaki","year":"1989","unstructured":"O. Ezaki, IIb group metal ions (Zn2+, Cd2+, Hg2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes,J. Biol. Chem. 264, 16,118\u201316,122 (1989).","journal-title":"J. Biol. Chem."},{"key":"BF02789090_CR17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.2337\/diab.41.8.982","volume":"41","author":"A. Shisheva","year":"1992","unstructured":"A. Shisheva, D. Gefel, and Y. Shechter, Insulinlike effects of zinc ion in vitro and in vivo: preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats,Diabetes 41, 982\u2013988 (1992).","journal-title":"Diabetes"},{"key":"BF02789090_CR18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1152\/physrev.1979.59.3.719","volume":"59","author":"G. A. Bray","year":"1979","unstructured":"G. A. Bray and D. A. York, Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis,Physiol. Rev. 59, 719\u2013809 (1979).","journal-title":"Physiol. Rev."},{"key":"BF02789090_CR19","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0076-6879(88)58073-4","volume":"158","author":"K. H. Falchuk","year":"1988","unstructured":"K. H. Falchuk, K. L. Hilt, and B. L. Vallee, Determination of zinc in biological samples by atomic absorption spectrometry,Method Enzymol. 158, 422\u2013434 (1988).","journal-title":"Method Enzymol."},{"key":"BF02789090_CR20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)51687-2","volume":"239","author":"M. Rodbell","year":"1964","unstructured":"M. Rodbell, Metabolism of isolated fat cells, I. Effects of hormones on glucose metabolism and lipolysis,J. Biol. Chem. 239, 375\u2013380 (1964).","journal-title":"J. Biol. Chem."},{"key":"BF02789090_CR21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"F. Denizot","year":"1986","unstructured":"F. Denizot and R. Lang, Rapid colorimetric assay for cell growth survival,J. Immunol. Method. 89, 271\u2013277 (1986).","journal-title":"J. Immunol. Method."},{"key":"BF02789090_CR22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/bj1840107","volume":"184","author":"J. A. Carnie","year":"1979","unstructured":"J. A. Carnie, D. G. Smith, and M. Mavris-Vavayannis, Effects of insulin on lipolysis and lipogenesis in adipocytes from genetically obese (ob\/ob) mice,Biochem. J. 184, 107\u2013112 (1979).","journal-title":"Biochem. J."},{"key":"BF02789090_CR23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1055\/s-0028-1093439","volume":"10","author":"S. R. Jooly","year":"1978","unstructured":"S. R. Jooly, J. J. Lech, and L. A. Menahan, Influence of genetic obesity in mice on the lipolytic response of isolated adipocytes to isoproterenol an ACTH-(l-24),Horm. Metab. Res. 10, 223\u2013227 (1978).","journal-title":"Horm. Metab. Res."},{"key":"BF02789090_CR24","volume-title":"SAS users guide: statistics","author":"Statistical Analysis System Institute Inc","year":"1985","unstructured":"Statistical Analysis System Institute Inc,SAS users guide: statistics, SAS Institute, Cary, NC (1985)."},{"key":"BF02789090_CR25","first-page":"415","volume":"13","author":"H. Yki-Jarvinen","year":"1992","unstructured":"H. Yki-Jarvinen, Glucose toxicity,Endocrine Rev. 13, 415\u2013431 (1992).","journal-title":"Endocrine Rev."},{"key":"BF02789090_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-08-092469-4.50005-4","volume-title":"in Trace Elements in Human and Animal Nutrition-Fifth Edition","author":"M. K. Hambridge","year":"1986","unstructured":"M. K. Hambridge, C. E. Casey, and N. F. Krebs, Zinc,in Trace Elements in Human and Animal Nutrition-Fifth Edition, W. Mertz, ed., Academic, New York, pp. 1\u2013137 (1986)."},{"key":"BF02789090_CR27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00140481","volume":"7","author":"J. A. Fernandez-Lopez","year":"1994","unstructured":"J. A. Fernandez-Lopez, M. Esteve, I. Rafecas, X. Remesar, and M. Alemany, Management of dietary essential metals (iron, copper, zinc, chromium and manganese) by Wistar and Zucker obese rats fed a self-selected high-energy diet,Biometals 7, 117\u2013129 (1994).","journal-title":"Biometals"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02789090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02789090\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02789090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T05:25:48Z","timestamp":1630387548000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02789090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["BF02789090"],"URL":"https:\/\/doi.org\/10.1007\/bf02789090","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}