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Dehydrating agents such as dimethylsulfoxide and dimethylsulfone greatly enhanced the initial rate of the fusion process, the effect of dimethylsulfone doubling that of dimethylsulfoxide. The effect of poly(ethylene glycol) on the fusion process was found to be dependent on the polymer concentration and molecular weight. In general, similar observations were made for both viruses. These results stress the importance of dehydration and hydrophobic interactions in the fusion activity of influenza and Sendai viruses, and show that these factors may be generally involved in membrane fusion events mediated by many other lipid enveloped viruses.<\/jats:p>","DOI":"10.1007\/bf01901634","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T16:20:40Z","timestamp":1122654040000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of hydrophobic interactions in the fusion activity of influenza and sendai viruses towards model membranes"],"prefix":"10.1042","volume":"14","author":[{"given":"Jo\u00e3o","family":"Ramalho-Santos","sequence":"first","affiliation":[{"name":"Department of Zoology, Center for Cell Biology and Center for Neurosciences of Coimbra, University of Coimbra, 3049 Coimbra Codex, Portugal"}]},{"given":"Ricardo","family":"Negr\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center for Cell Biology and Center for Neurosciences of Coimbra, University of Coimbria, 3049 Coimbra Codex, Portugal"}]},{"given":"Maria da Concei\u00e7\u00e3o Pedroso","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center for Cell Biology and Center for Neurosciences of Coimbra, University of Coimbria, 3049 Coimbra Codex, Portugal"}]}],"member":"288","reference":[{"key":"BF01901634_CR1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.bi.56.070187.002053","volume":"56","author":"D. 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