{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:06:55Z","timestamp":1773644815356,"version":"3.50.1"},"reference-count":147,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s00018-013-1290-8","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T02:22:25Z","timestamp":1362104545000},"page":"3871-3882","source":"Crossref","is-referenced-by-count":279,"title":["Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?"],"prefix":"10.1007","volume":"70","author":[{"given":"F\u00e1bio G.","family":"Teixeira","sequence":"first","affiliation":[]},{"given":"Miguel M.","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio J.","family":"Salgado","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"issue":"1","key":"1290_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/gt.2010.130","volume":"18","author":"S Gogel","year":"2011","unstructured":"Gogel S, Gubernator M, Minger SL (2011) Progress and prospects: stem cells and neurological diseases. Gene Ther 18(1):1\u20136","journal-title":"Gene Ther"},{"issue":"1","key":"1290_CR2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI40543","volume":"120","author":"O Lindvall","year":"2010","unstructured":"Lindvall O, Kokaia Z (2010) Stem cells in human neurodegenerative disorders\u2014time for clinical translation? J Clin Invest 120(1):29\u201340","journal-title":"J Clin Invest"},{"issue":"2","key":"1290_CR3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.stem.2012.01.009","volume":"10","author":"O Lindvall","year":"2012","unstructured":"Lindvall O, Barker RA, Brustle O et al (2012) Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell 10(2):151\u2013155","journal-title":"Cell Stem Cell"},{"issue":"2","key":"1290_CR4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12015-010-9195-5","volume":"7","author":"J Becerra","year":"2011","unstructured":"Becerra J, Santos-Ruiz L, Andrades JA et al (2011) The stem cell niche should be a key issue for cell therapy in regenerative medicine. Stem Cell Rev 7(2):248\u2013255","journal-title":"Stem Cell Rev"},{"issue":"12","key":"1290_CR5","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1016\/j.biomaterials.2010.12.032","volume":"32","author":"FM Chen","year":"2011","unstructured":"Chen FM, Wu LA, Zhang M et al (2011) Homing of endogenous stem\/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives. Biomaterials 32(12):3189\u20133209","journal-title":"Biomaterials"},{"issue":"3","key":"1290_CR6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.biotechadv.2011.11.005","volume":"30","author":"FM Chen","year":"2012","unstructured":"Chen FM, Zhao YM, Jin Y et al (2012) Prospects for translational regenerative medicine. Biotechnol Adv 30(3):658\u2013672","journal-title":"Biotechnol Adv"},{"issue":"5","key":"1290_CR7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1742-7843.2004.pto950502.x","volume":"95","author":"M Kassem","year":"2004","unstructured":"Kassem M, Kristiansen M, Abdallah BM (2004) Mesenchymal stem cells: cell biology and potential use in therapy. Basic Clin Pharmacol Toxicol 95(5):209\u2013214","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"4","key":"1290_CR8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s11684-011-0164-4","volume":"5","author":"S Wang","year":"2011","unstructured":"Wang S, Qu X, Zhao RC (2011) Mesenchymal stem cells hold promise for regenerative medicine. Front Med 5(4):372\u2013378","journal-title":"Front Med"},{"issue":"1","key":"1290_CR9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.beha.2011.01.004","volume":"24","author":"A Uccelli","year":"2011","unstructured":"Uccelli A, Benvenuto F, Laroni A et al (2011) Neuroprotective features of mesenchymal stem cells. Best Pract Res Clin Haematol 24(1):59\u201364","journal-title":"Best Pract Res Clin Haematol"},{"issue":"7","key":"1290_CR10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1474-4422(11)70121-1","volume":"10","author":"A Uccelli","year":"2011","unstructured":"Uccelli A, Laroni A, Freedman MS (2011) Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol 10(7):649\u2013656","journal-title":"Lancet Neurol"},{"issue":"4","key":"1290_CR11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315\u2013317","journal-title":"Cytotherapy"},{"issue":"2","key":"1290_CR12","first-page":"83","volume":"2","author":"AJ Friedenstein","year":"1974","unstructured":"Friedenstein AJ, Deriglasova UF, Kulagina NN et al (1974) Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol 2(2):83\u201392","journal-title":"Exp Hematol"},{"issue":"12","key":"1290_CR13","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1091\/mbc.E02-02-0105","volume":"13","author":"PA Zuk","year":"2002","unstructured":"Zuk PA, Zuk M, Ashjian P et al (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13(12):4279\u20134295","journal-title":"Mol Biol Cell"},{"issue":"2","key":"1290_CR14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","volume":"7","author":"PA Zuk","year":"2001","unstructured":"Zuk PA, Zuk M, Mizuno H et al (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7(2):211\u2013228","journal-title":"Tissue Eng"},{"issue":"25","key":"1290_CR15","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","volume":"97","author":"S Gronthos","year":"2000","unstructured":"Gronthos S, Mankani M, Brahim J et al (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97(25):13625\u201313630","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"1290_CR16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1359\/jbmr.2003.18.4.696","volume":"18","author":"S Shi","year":"2003","unstructured":"Shi S, Gronthos S (2003) Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 18(4):696\u2013704","journal-title":"J Bone Miner Res"},{"issue":"5","key":"1290_CR17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1634\/stemcells.22-5-649","volume":"22","author":"Y Fukuchi","year":"2004","unstructured":"Fukuchi Y, Nakajima H, Sugiyama D et al (2004) Human placenta-derived cells have mesenchymal stem\/progenitor cell potential. Stem Cells 22(5):649\u2013658","journal-title":"Stem Cells"},{"issue":"1","key":"1290_CR18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12015-012-9385-4","volume":"9","author":"MH Abumaree","year":"2012","unstructured":"Abumaree MH, Al Jumah M, Kalionis B et al. (2012) Phenotypic and functional characterization of mesenchymal stem cells from chorionic villi of human term placenta. Stem Cell Rev 9(1):16\u201331","journal-title":"Stem Cell Rev"},{"issue":"1","key":"1290_CR19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2141.2000.01986.x","volume":"109","author":"A Erices","year":"2000","unstructured":"Erices A, Conget P, Minguell JJ (2000) Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 109(1):235\u2013242","journal-title":"Br J Haematol"},{"issue":"7","key":"1290_CR20","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","volume":"22","author":"HS Wang","year":"2004","unstructured":"Wang HS, Hung SC, Peng ST et al (2004) Mesenchymal stem cells in the Wharton\u2019s jelly of the human umbilical cord. Stem Cells 22(7):1330\u20131337","journal-title":"Stem Cells"},{"issue":"2","key":"1290_CR21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12015-006-0022-y","volume":"2","author":"ML Weiss","year":"2006","unstructured":"Weiss ML, Troyer DL (2006) Stem cells in the umbilical cord. Stem Cell Rev 2(2):155\u2013162","journal-title":"Stem Cell Rev"},{"issue":"4","key":"1290_CR22","doi-asserted-by":"crossref","first-page":"e35577","DOI":"10.1371\/journal.pone.0035577","volume":"7","author":"G Paul","year":"2012","unstructured":"Paul G, Ozen I, Christophersen NS et al (2012) The adult human brain harbors multipotent perivascular mesenchymal stem cells. PLoS One 7(4):e35577","journal-title":"PLoS One"},{"issue":"11","key":"1290_CR23","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","volume":"25","author":"G Chamberlain","year":"2007","unstructured":"Chamberlain G, Fox J, Ashton B et al (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25(11):2739\u20132749","journal-title":"Stem Cells"},{"issue":"5\u20136","key":"1290_CR24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cytogfr.2009.10.002","volume":"20","author":"S Meirelles Lda","year":"2009","unstructured":"Meirelles Lda S, Fontes AM, Covas DT et al (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20(5\u20136):419\u2013427","journal-title":"Cytokine Growth Factor Rev"},{"issue":"23","key":"1290_CR25","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.4161\/cc.6.23.5095","volume":"6","author":"DG Phinney","year":"2007","unstructured":"Phinney DG (2007) Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle 6(23):2884\u20132889","journal-title":"Cell Cycle"},{"issue":"11","key":"1290_CR26","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","volume":"25","author":"DG Phinney","year":"2007","unstructured":"Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair\u2013current views. Stem Cells 25(11):2896\u20132902","journal-title":"Stem Cells"},{"issue":"1","key":"1290_CR27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/ar2116","volume":"9","author":"CM Kolf","year":"2007","unstructured":"Kolf CM, Cho E, Tuan RS (2007) Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 9(1):204","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"1290_CR28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1634\/stemcells.21-1-50","volume":"21","author":"KE Mitchell","year":"2003","unstructured":"Mitchell KE, Weiss ML, Mitchell BM et al (2003) Matrix cells from Wharton\u2019s jelly form neurons and glia. Stem Cells 21(1):50\u201360","journal-title":"Stem Cells"},{"issue":"3","key":"1290_CR29","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/jcp.22062","volume":"223","author":"M Alaminos","year":"2010","unstructured":"Alaminos M, Perez-Kohler B, Garzon I et al (2010) Transdifferentiation potentiality of human Wharton\u2019s jelly stem cells towards vascular endothelial cells. J Cell Physiol 223(3):640\u2013647","journal-title":"J Cell Physiol"},{"issue":"8","key":"1290_CR30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/WNR.0b013e3283469615","volume":"22","author":"Y Liqing","year":"2011","unstructured":"Liqing Y, Jia G, Jiqing C et al (2011) Directed differentiation of motor neuron cell-like cells from human adipose-derived stem cells in vitro. NeuroReport 22(8):370\u2013373","journal-title":"NeuroReport"},{"key":"1290_CR31","first-page":"812693","volume":"2012","author":"PC Baer","year":"2012","unstructured":"Baer PC, Geiger H (2012) Adipose-derived mesenchymal stromal\/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int 2012:812693","journal-title":"Stem Cells Int"},{"issue":"3","key":"1290_CR32","first-page":"347","volume":"59","author":"DJ Maltman","year":"2011","unstructured":"Maltman DJ, Hardy SA, Przyborski SA (2011) Role of mesenchymal stem cells in neurogenesis and nervous system repair. Neurochem Int 59(3):347\u2013356","journal-title":"Neurochem Int"},{"issue":"12","key":"1290_CR33","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.addr.2010.09.013","volume":"62","author":"T Meyerrose","year":"2010","unstructured":"Meyerrose T, Olson S, Pontow S et al (2010) Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors. Adv Drug Deliv Rev 62(12):1167\u20131174","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"1290_CR34","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/pmic.201000402","volume":"11","author":"H Skalnikova","year":"2011","unstructured":"Skalnikova H, Motlik J, Gadher SJ et al (2011) Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines. Proteomics 11(4):691\u2013708","journal-title":"Proteomics"},{"issue":"4","key":"1290_CR35","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1371\/journal.pone.0001886","volume":"3","author":"L Chen","year":"2008","unstructured":"Chen L, Tredget EE, Wu PY et al (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3(4):e1886","journal-title":"PLoS One"},{"issue":"3","key":"1290_CR36","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1634\/stemcells.2008-0742","volume":"27","author":"GJ Block","year":"2009","unstructured":"Block GJ, Ohkouchi S, Fung F et al (2009) Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells 27(3):670\u2013681","journal-title":"Stem Cells"},{"issue":"5","key":"1290_CR37","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.copbio.2009.08.009","volume":"20","author":"J Wagner","year":"2009","unstructured":"Wagner J, Kean T, Young R et al (2009) Optimizing mesenchymal stem cell-based therapeutics. Curr Opin Biotechnol 20(5):531\u2013536","journal-title":"Curr Opin Biotechnol"},{"key":"1290_CR38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fphys.2012.00359","volume":"3","author":"SR Baglio","year":"2012","unstructured":"Baglio SR, Pegtel DM, Baldini N (2012) Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 3:359","journal-title":"Front Physiol"},{"issue":"6","key":"1290_CR39","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstrom K, Bossios A et al (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9(6):654\u2013659","journal-title":"Nat Cell Biol"},{"issue":"14","key":"1290_CR40","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.0914843107","volume":"107","author":"DM Pegtel","year":"2010","unstructured":"Pegtel DM, Cosmopoulos K, Thorley-Lawson DA et al (2010) Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci USA 107(14):6328\u20136333","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1290_CR41","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","volume":"4","author":"RC Lai","year":"2010","unstructured":"Lai RC, Arslan F, Lee MM et al (2010) Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury. Stem Cell Res 4(3):214\u2013222","journal-title":"Stem Cell Res"},{"key":"1290_CR42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1479-5876-9-47","volume":"9","author":"TS Chen","year":"2011","unstructured":"Chen TS, Arslan F, Yin Y et al (2011) Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med 9:47","journal-title":"J Transl Med"},{"issue":"5","key":"1290_CR43","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/cr.2010.44","volume":"20","author":"Y Shi","year":"2010","unstructured":"Shi Y, Hu G, Su J et al (2010) Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res 20(5):510\u2013518","journal-title":"Cell Res"},{"issue":"4","key":"1290_CR44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/14653240903080367","volume":"11","author":"JA Kode","year":"2009","unstructured":"Kode JA, Mukherjee S, Joglekar MV et al (2009) Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 11(4):377\u2013391","journal-title":"Cytotherapy"},{"issue":"1","key":"1290_CR45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2141.2005.05409.x","volume":"129","author":"B Puissant","year":"2005","unstructured":"Puissant B, Barreau C, Bourin P et al (2005) Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 129(1):118\u2013129","journal-title":"Br J Haematol"},{"issue":"5","key":"1290_CR46","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/j.1471-4159.2009.06268.x","volume":"110","author":"C Lanza","year":"2009","unstructured":"Lanza C, Morando S, Voci A et al (2009) Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. J Neurochem 110(5):1674\u20131684","journal-title":"J Neurochem"},{"issue":"5","key":"1290_CR47","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","volume":"98","author":"AI Caplan","year":"2006","unstructured":"Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98(5):1076\u20131084","journal-title":"J Cell Biochem"},{"issue":"1","key":"1290_CR48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2005.10.029","volume":"198","author":"L Crigler","year":"2006","unstructured":"Crigler L, Robey RC, Asawachaicharn A et al (2006) Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol 198(1):54\u201364","journal-title":"Exp Neurol"},{"issue":"1","key":"1290_CR49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neulet.2010.07.062","volume":"483","author":"N Nakano","year":"2010","unstructured":"Nakano N, Nakai Y, Seo TB et al (2010) Characterization of conditioned medium of cultured bone marrow stromal cells. Neurosci Lett 483(1):57\u201361","journal-title":"Neurosci Lett"},{"issue":"1","key":"1290_CR50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.scr.2009.02.006","volume":"3","author":"A Wilkins","year":"2009","unstructured":"Wilkins A, Kemp K, Ginty M et al (2009) Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro. Stem Cell Res 3(1):63\u201370","journal-title":"Stem Cell Res"},{"issue":"8","key":"1290_CR51","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/term.365","volume":"5","author":"CA Ribeiro","year":"2011","unstructured":"Ribeiro CA, Salgado AJ, Fraga JS et al (2011) The secretome of bone marrow mesenchymal stem cells\u2014conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures). J Tissue Eng Regen Med 5(8):668\u2013672","journal-title":"J Tissue Eng Regen Med"},{"key":"1290_CR52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2009.11.041","volume":"1311","author":"L Cova","year":"2010","unstructured":"Cova L, Armentero MT, Zennaro E et al (2010) Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson\u2019s disease. Brain Res 1311:12\u201327","journal-title":"Brain Res"},{"issue":"2","key":"1290_CR53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2990.2010.01124.x","volume":"37","author":"C Nicaise","year":"2011","unstructured":"Nicaise C, Mitrecic D, Pochet R (2011) Brain and spinal cord affected by amyotrophic lateral sclerosis induce differential growth factors expression in rat mesenchymal and neural stem cells. Neuropathol Appl Neurobiol 37(2):179\u2013188","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"10","key":"1290_CR54","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","volume":"109","author":"J Rehman","year":"2004","unstructured":"Rehman J, Traktuev D, Li J et al (2004) Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109(10):1292\u20131298","journal-title":"Circulation"},{"issue":"2","key":"1290_CR55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/157488810791268564","volume":"5","author":"AJ Salgado","year":"2010","unstructured":"Salgado AJ, Reis RL, Sousa NJ et al (2010) Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine. Curr Stem Cell Res Ther 5(2):103\u2013110","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1\u20133","key":"1290_CR56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tox.2010.10.011","volume":"279","author":"S Lu","year":"2011","unstructured":"Lu S, Lu C, Han Q et al (2011) Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K\/Akt activation. Toxicology 279(1\u20133):189\u2013195","journal-title":"Toxicology"},{"key":"1290_CR57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuroscience.2011.02.038","volume":"181","author":"B Tan","year":"2011","unstructured":"Tan B, Luan Z, Wei X et al (2011) AMP-activated kinase mediates adipose stem cell-stimulated neuritogenesis of PC12 cells. Neuroscience 181:40\u201347","journal-title":"Neuroscience"},{"issue":"2","key":"1290_CR58","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1634\/stemcells.2008-0333","volume":"27","author":"X Wei","year":"2009","unstructured":"Wei X, Du Z, Zhao L et al (2009) IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 27(2):478\u2013488","journal-title":"Stem Cells"},{"issue":"3","key":"1290_CR59","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/scrt109","volume":"3","author":"CA Ribeiro","year":"2012","unstructured":"Ribeiro CA, Fraga JS, Graos M et al (2012) The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations. Stem Cell Res Ther 3(3):18","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"1290_CR60","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10571-011-9712-3","volume":"31","author":"D Arboleda","year":"2011","unstructured":"Arboleda D, Forostyak S, Jendelova P et al (2011) Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury. Cell Mol Neurobiol 31(7):1113\u20131122","journal-title":"Cell Mol Neurobiol"},{"key":"1290_CR61","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2012.04.033","volume":"1461","author":"Y Egashira","year":"2012","unstructured":"Egashira Y, Sugitani S, Suzuki Y et al (2012) The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model. Brain Res 1461:87\u201395","journal-title":"Brain Res"},{"issue":"3","key":"1290_CR62","doi-asserted-by":"crossref","first-page":"e17899","DOI":"10.1371\/journal.pone.0017899","volume":"6","author":"T Lopatina","year":"2011","unstructured":"Lopatina T, Kalinina N, Karagyaur M et al (2011) Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 6(3):e17899","journal-title":"PLoS One"},{"key":"1290_CR63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainres.2008.06.087","volume":"1229","author":"SH Koh","year":"2008","unstructured":"Koh SH, Kim KS, Choi MR et al (2008) Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats. Brain Res 1229:233\u2013248","journal-title":"Brain Res"},{"issue":"7","key":"1290_CR64","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1089\/scd.2009.0279","volume":"19","author":"AJ Salgado","year":"2010","unstructured":"Salgado AJ, Fraga JS, Mesquita AR et al (2010) Role of human umbilical cord mesenchymal progenitors conditioned media in neuronal\/glial cell densities, viability, and proliferation. Stem Cells Dev 19(7):1067\u20131074","journal-title":"Stem Cells Dev"},{"issue":"3","key":"1290_CR65","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.nbd.2007.06.010","volume":"27","author":"DC Ding","year":"2007","unstructured":"Ding DC, Shyu WC, Chiang MF et al (2007) Enhancement of neuroplasticity through upregulation of beta1-integrin in human umbilical cord-derived stromal cell implanted stroke model. Neurobiol Dis 27(3):339\u2013353","journal-title":"Neurobiol Dis"},{"issue":"7","key":"1290_CR66","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/jcbfm.2011.187","volume":"32","author":"K Abe","year":"2012","unstructured":"Abe K, Yamashita T, Takizawa S et al (2012) Stem cell therapy for cerebral ischemia: from basic science to clinical applications. J Cereb Blood Flow Metab 32(7):1317\u20131331","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"1290_CR67","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3109\/14653249.2010.487899","volume":"12","author":"R Pal","year":"2010","unstructured":"Pal R, Gopinath C, Rao NM et al (2010) Functional recovery after transplantation of bone marrow-derived human mesenchymal stromal cells in a rat model of spinal cord injury. Cytotherapy 12(6):792\u2013806","journal-title":"Cytotherapy"},{"issue":"12","key":"1290_CR68","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1007\/s00415-011-6110-1","volume":"258","author":"HJ Kim","year":"2011","unstructured":"Kim HJ, Kim HJ, Lee JY et al (2011) Phenotype analysis in patients with early onset Parkinson\u2019s disease with and without parkin mutations. J Neurol 258(12):2260\u20132267","journal-title":"J Neurol"},{"issue":"4","key":"1290_CR69","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5483\/BMBRep.2010.43.4.225","volume":"43","author":"YC Chung","year":"2010","unstructured":"Chung YC, Ko HW, Bok E et al (2010) The role of neuroinflammation on the pathogenesis of Parkinson\u2019s disease. BMB Rep 43(4):225\u2013232","journal-title":"BMB Rep"},{"issue":"5\u20136","key":"1290_CR70","first-page":"347","volume":"20","author":"SV Anisimov","year":"2009","unstructured":"Anisimov SV (2009) Cell-based therapeutic approaches for Parkinson\u2019s disease: progress and perspectives. Rev Neurosci 20(5\u20136):347\u2013381","journal-title":"Rev Neurosci"},{"issue":"1","key":"1290_CR71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pneurobio.2006.11.009","volume":"81","author":"N Singh","year":"2007","unstructured":"Singh N, Pillay V, Choonara YE (2007) Advances in the treatment of Parkinson\u2019s disease. Prog Neurobiol 81(1):29\u201344","journal-title":"Prog Neurobiol"},{"issue":"Suppl 6","key":"1290_CR72","first-page":"VI\/44","volume":"251","author":"T Muller","year":"2004","unstructured":"Muller T, Hefter H, Hueber R et al (2004) Is levodopa toxic? J Neurol 251(Suppl 6):VI\/44\u2013VI\/46","journal-title":"J Neurol"},{"issue":"5","key":"1290_CR73","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/archneur.61.5.657","volume":"61","author":"T Muller","year":"2004","unstructured":"Muller T, Renger K, Kuhn W (2004) Levodopa-associated increase of homocysteine levels and sural axonal neurodegeneration. Arch Neurol 61(5):657\u2013660","journal-title":"Arch Neurol"},{"issue":"4","key":"1290_CR74","first-page":"191","volume":"3","author":"WJ Weiner","year":"2006","unstructured":"Weiner WJ (2006) Advances in the diagnosis, treatment, and understanding of Parkinson\u2019s disease and parkinsonism. Rev Neurol Dis 3(4):191\u2013194","journal-title":"Rev Neurol Dis"},{"issue":"4942","key":"1290_CR75","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1126\/science.2105529","volume":"247","author":"O Lindvall","year":"1990","unstructured":"Lindvall O, Brundin P, Widner H et al (1990) Grafts of fetal dopamine neurons survive and improve motor function in Parkinson\u2019s disease. Science 247(4942):574\u2013577","journal-title":"Science"},{"issue":"6","key":"1290_CR76","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archneur.1989.00520420033021","volume":"46","author":"O Lindvall","year":"1989","unstructured":"Lindvall O, Rehncrona S, Brundin P et al (1989) Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson\u2019s disease. A detailed account of methodology and a 6-month follow-up. Arch Neurol 46(6):615\u2013631","journal-title":"Arch Neurol"},{"issue":"2","key":"1290_CR77","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ana.410310206","volume":"31","author":"O Lindvall","year":"1992","unstructured":"Lindvall O, Widner H, Rehncrona S et al (1992) Transplantation of fetal dopamine neurons in Parkinson\u2019s disease: one-year clinical and neurophysiological observations in two patients with putaminal implants. Ann Neurol 31(2):155\u2013165","journal-title":"Ann Neurol"},{"issue":"2","key":"1290_CR78","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ana.410310207","volume":"31","author":"GV Sawle","year":"1992","unstructured":"Sawle GV, Bloomfield PM, Bjorklund A et al (1992) Transplantation of fetal dopamine neurons in Parkinson\u2019s disease: PET [18F]6-L-fluorodopa studies in two patients with putaminal implants. Ann Neurol 31(2):166\u2013173","journal-title":"Ann Neurol"},{"issue":"4","key":"1290_CR79","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2174\/157015910793358204","volume":"8","author":"MF Azari","year":"2010","unstructured":"Azari MF, Mathias L, Ozturk E et al (2010) Mesenchymal stem cells for treatment of CNS injury. Curr Neuropharmacol 8(4):316\u2013323","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"1290_CR80","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11481-007-9074-2","volume":"2","author":"Y Wang","year":"2007","unstructured":"Wang Y, Chen S, Yang D et al (2007) Stem cell transplantation: a promising therapy for Parkinson\u2019s disease. J Neuroimmune Pharmacol 2(3):243\u2013250","journal-title":"J Neuroimmune Pharmacol"},{"issue":"7","key":"1290_CR81","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.neuint.2008.02.003","volume":"52","author":"G Bouchez","year":"2008","unstructured":"Bouchez G, Sensebe L, Vourc\u2019h P et al (2008) Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson\u2019s disease. Neurochem Int 52(7):1332\u20131342","journal-title":"Neurochem Int"},{"issue":"4","key":"1290_CR82","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/14653240802021330","volume":"10","author":"YS Levy","year":"2008","unstructured":"Levy YS, Bahat-Stroomza M, Barzilay R et al (2008) Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson\u2019s disease. Cytotherapy 10(4):340\u2013352","journal-title":"Cytotherapy"},{"issue":"1","key":"1290_CR83","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/CBI20090012","volume":"34","author":"GZ Jin","year":"2010","unstructured":"Jin GZ, Cho SJ, Lee YS et al (2010) Intrastriatal grafts of mesenchymal stem cells in adult intact rats can elevate tyrosine hydroxylase expression and dopamine levels. Cell Biol Int 34(1):135\u2013140","journal-title":"Cell Biol Int"},{"issue":"1","key":"1290_CR84","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.expneurol.2007.10.011","volume":"210","author":"MK McCoy","year":"2008","unstructured":"McCoy MK, Martinez TN, Ruhn KA et al (2008) Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson\u2019s disease. Exp Neurol 210(1):14\u201329","journal-title":"Exp Neurol"},{"issue":"1","key":"1290_CR85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1634\/stemcells.2005-0053","volume":"24","author":"YS Fu","year":"2006","unstructured":"Fu YS, Cheng YC, Lin MY et al (2006) Conversion of human umbilical cord mesenchymal stem cells in Wharton\u2019s jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells 24(1):115\u2013124","journal-title":"Stem Cells"},{"issue":"1","key":"1290_CR86","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2007.03.070","volume":"419","author":"I Kan","year":"2007","unstructured":"Kan I, Ben-Zur T, Barhum Y et al (2007) Dopaminergic differentiation of human mesenchymal stem cells\u2014utilization of bioassay for tyrosine hydroxylase expression. Neurosci Lett 419(1):28\u201333","journal-title":"Neurosci Lett"},{"issue":"1\u20132","key":"1290_CR87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneuroim.2009.09.003","volume":"216","author":"YX Chao","year":"2009","unstructured":"Chao YX, He BP, Tay SS (2009) Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson\u2019s disease. J Neuroimmunol 216(1\u20132):39\u201350","journal-title":"J Neuroimmunol"},{"issue":"2","key":"1290_CR88","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.trsl.2010.11.001","volume":"157","author":"MG Thomas","year":"2011","unstructured":"Thomas MG, Stone L, Evill L et al (2011) Bone marrow stromal cells as replacement cells for Parkinson\u2019s disease: generation of an anatomical but not functional neuronal phenotype. Transl Res 157(2):56\u201363","journal-title":"Transl Res"},{"key":"1290_CR89","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2202-11-52","volume":"11","author":"F Wang","year":"2010","unstructured":"Wang F, Yasuhara T, Shingo T et al (2010) Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alpha. BMC Neurosci 11:52","journal-title":"BMC Neurosci"},{"issue":"3","key":"1290_CR90","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1634\/stemcells.2005-0330","volume":"24","author":"ML Weiss","year":"2006","unstructured":"Weiss ML, Medicetty S, Bledsoe AR et al (2006) Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson\u2019s disease. Stem Cells 24(3):781\u2013792","journal-title":"Stem Cells"},{"issue":"8","key":"1290_CR91","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/scd.2008.0411","volume":"18","author":"O Sadan","year":"2009","unstructured":"Sadan O, Bahat-Stromza M, Barhum Y et al (2009) Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease. Stem Cells Dev 18(8):1179\u20131190","journal-title":"Stem Cells Dev"},{"issue":"4","key":"1290_CR92","first-page":"201","volume":"11","author":"O Sadan","year":"2009","unstructured":"Sadan O, Shemesh N, Cohen Y et al (2009) Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases. Isr Med Assoc J 11(4):201\u2013204","journal-title":"Isr Med Assoc J"},{"issue":"2","key":"1290_CR93","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3727\/096368909X479839","volume":"19","author":"F Blandini","year":"2010","unstructured":"Blandini F, Cova L, Armentero MT et al (2010) Transplantation of undifferentiated human mesenchymal stem cells protects against 6-hydroxydopamine neurotoxicity in the rat. Cell Transplant 19(2):203\u2013217","journal-title":"Cell Transplant"},{"issue":"Suppl 3","key":"1290_CR94","doi-asserted-by":"crossref","first-page":"S613","DOI":"10.1002\/mds.22061","volume":"23","author":"CW Olanow","year":"2008","unstructured":"Olanow CW (2008) Levodopa\/dopamine replacement strategies in Parkinson\u2019s disease\u2013future directions. Mov Disord 23(Suppl 3):S613\u2013S622","journal-title":"Mov Disord"},{"key":"1290_CR95","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2010.08.040","volume":"1359","author":"TC Moloney","year":"2010","unstructured":"Moloney TC, Rooney GE, Barry FP et al (2010) Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain. Brain Res 1359:33\u201343","journal-title":"Brain Res"},{"issue":"2","key":"1290_CR96","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00381-010-1312-x","volume":"27","author":"MM Mortazavi","year":"2011","unstructured":"Mortazavi MM, Verma K, Tubbs RS et al (2011) Cellular and paracellular transplants for spinal cord injury: a review of the literature. Childs Nerv Syst 27(2):237\u2013243","journal-title":"Childs Nerv Syst"},{"key":"1290_CR97","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2377-11-113","volume":"11","author":"RA Watson","year":"2011","unstructured":"Watson RA, Yeung TM (2011) What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury? BMC Neurol 11:113","journal-title":"BMC Neurol"},{"issue":"1","key":"1290_CR98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pharmthera.2011.05.001","volume":"132","author":"AG Rabchevsky","year":"2011","unstructured":"Rabchevsky AG, Patel SP, Springer JE (2011) Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward? Pharmacol Ther 132(1):15\u201329","journal-title":"Pharmacol Ther"},{"key":"1290_CR99","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2011.03.019","volume":"1391","author":"AJ Shang","year":"2011","unstructured":"Shang AJ, Hong SQ, Xu Q et al (2011) NT-3-secreting human umbilical cord mesenchymal stromal cell transplantation for the treatment of acute spinal cord injury in rats. Brain Res 1391:102\u2013113","journal-title":"Brain Res"},{"issue":"1\u20132","key":"1290_CR100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2006.03.069","volume":"402","author":"M Zurita","year":"2006","unstructured":"Zurita M, Vaquero J (2006) Bone marrow stromal cells can achieve cure of chronic paraplegic rats: functional and morphological outcome one year after transplantation. Neurosci Lett 402(1\u20132):51\u201356","journal-title":"Neurosci Lett"},{"key":"1290_CR101","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainres.2010.03.043","volume":"1332","author":"C Ide","year":"2010","unstructured":"Ide C, Nakai Y, Nakano N et al (2010) Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat. Brain Res 1332:32\u201347","journal-title":"Brain Res"},{"issue":"10","key":"1290_CR102","doi-asserted-by":"crossref","first-page":"e3336","DOI":"10.1371\/journal.pone.0003336","volume":"3","author":"CC Yang","year":"2008","unstructured":"Yang CC, Shih YH, Ko MH et al (2008) Transplantation of human umbilical mesenchymal stem cells from Wharton\u2019s jelly after complete transection of the rat spinal cord. PLoS One 3(10):e3336","journal-title":"PLoS One"},{"issue":"1","key":"1290_CR103","first-page":"107","volume":"24","author":"J Vaquero","year":"2009","unstructured":"Vaquero J, Zurita M (2009) Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol 24(1):107\u2013116","journal-title":"Histol Histopathol"},{"issue":"2","key":"1290_CR104","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/stem.570","volume":"29","author":"KT Wright","year":"2011","unstructured":"Wright KT, El Masri W, Osman A et al (2011) Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells 29(2):169\u2013178","journal-title":"Stem Cells"},{"issue":"2","key":"1290_CR105","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.bbrc.2007.01.013","volume":"354","author":"KT Wright","year":"2007","unstructured":"Wright KT, El Masri W, Osman A et al (2007) Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. Biochem Biophys Res Commun 354(2):559\u2013566","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"1290_CR106","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.expneurol.2004.09.018","volume":"191","author":"P Lu","year":"2005","unstructured":"Lu P, Jones LL, Tuszynski MH (2005) BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 191(2):344\u2013360","journal-title":"Exp Neurol"},{"issue":"1","key":"1290_CR107","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2004.11.055","volume":"1035","author":"B Neuhuber","year":"2005","unstructured":"Neuhuber B, Timothy Hilmes B, Shumsky JS et al (2005) Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 1035(1):73\u201385","journal-title":"Brain Res"},{"issue":"3","key":"1290_CR108","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1440-1789.2009.01063.x","volume":"30","author":"W Gu","year":"2010","unstructured":"Gu W, Zhang F, Xue Q et al (2010) Transplantation of bone marrow mesenchymal stem cells reduces lesion volume and induces axonal regrowth of injured spinal cord. Neuropathology 30(3):205\u2013217","journal-title":"Neuropathology"},{"issue":"9","key":"1290_CR109","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/glia.20992","volume":"58","author":"HW Park","year":"2010","unstructured":"Park HW, Lim MJ, Jung H et al (2010) Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury. Glia 58(9):1118\u20131132","journal-title":"Glia"},{"issue":"11","key":"1290_CR110","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1007\/s11064-009-9992-x","volume":"34","author":"L Zhang","year":"2009","unstructured":"Zhang L, Zhang HT, Hong SQ et al (2009) Cografted Wharton\u2019s jelly cells-derived neurospheres and BDNF promote functional recovery after rat spinal cord transection. Neurochem Res 34(11):2030\u20132039","journal-title":"Neurochem Res"},{"key":"1290_CR111","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-211-35205-2_25","volume":"99","author":"KN Kim","year":"2006","unstructured":"Kim KN, Oh SH, Lee KH et al (2006) Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord. Acta Neurochir Suppl 99:133\u2013136","journal-title":"Acta Neurochir Suppl"},{"issue":"7","key":"1290_CR112","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.clineuro.2012.02.003","volume":"114","author":"S Karamouzian","year":"2012","unstructured":"Karamouzian S, Nematollahi-Mahani SN, Nakhaee N et al (2012) Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients. Clin Neurol Neurosurg 114(7):935\u2013939","journal-title":"Clin Neurol Neurosurg"},{"issue":"1","key":"1290_CR113","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/TA.0b013e31815b847d","volume":"64","author":"F Saito","year":"2008","unstructured":"Saito F, Nakatani T, Iwase M et al (2008) Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report. J Trauma 64(1):53\u201359","journal-title":"J Trauma"},{"issue":"2","key":"1290_CR114","first-page":"127","volume":"30","author":"F Saito","year":"2012","unstructured":"Saito F, Nakatani T, Iwase M et al (2012) Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: a pilot study. Restor Neurol Neurosci 30(2):127\u2013136","journal-title":"Restor Neurol Neurosci"},{"issue":"12","key":"1290_CR115","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1089\/scd.2011.0596","volume":"21","author":"GW Hawryluk","year":"2012","unstructured":"Hawryluk GW, Mothe A, Wang J et al (2012) An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury. Stem Cells Dev 21(12):2222\u20132238","journal-title":"Stem Cells Dev"},{"issue":"4","key":"1290_CR116","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s13311-011-0076-7","volume":"8","author":"MG Fehlings","year":"2011","unstructured":"Fehlings MG, Vawda R (2011) Cellular treatments for spinal cord injury: the time is right for clinical trials. Neurotherapeutics 8(4):704\u2013720","journal-title":"Neurotherapeutics"},{"issue":"4","key":"1290_CR117","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.tice.2012.03.003","volume":"44","author":"SO Yazdani","year":"2012","unstructured":"Yazdani SO, Pedram M, Hafizi M et al (2012) A comparison between neurally induced bone marrow derived mesenchymal stem cells and olfactory ensheathing glial cells to repair spinal cord injuries in rat. Tissue Cell 44(4):205\u2013213","journal-title":"Tissue Cell"},{"issue":"4","key":"1290_CR118","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1602\/neurorx.1.4.379","volume":"1","author":"O Lindvall","year":"2004","unstructured":"Lindvall O, Bjorklund A (2004) Cell replacement therapy: helping the brain to repair itself. NeuroRx 1(4):379\u2013381","journal-title":"NeuroRx"},{"issue":"2","key":"1290_CR119","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12975-010-0023-7","volume":"1","author":"M Ahmad","year":"2010","unstructured":"Ahmad M, Graham SH (2010) Inflammation after stroke: mechanisms and therapeutic approaches. Transl Stroke Res 1(2):74\u201384","journal-title":"Transl Stroke Res"},{"issue":"3","key":"1290_CR120","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s13311-011-0041-5","volume":"8","author":"N Shafi","year":"2011","unstructured":"Shafi N, Kasner SE (2011) Treatment of acute ischemic stroke: beyond thrombolysis and supportive care. Neurotherapeutics 8(3):425\u2013433","journal-title":"Neurotherapeutics"},{"issue":"5","key":"1290_CR121","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00018-008-8346-1","volume":"66","author":"F Locatelli","year":"2009","unstructured":"Locatelli F, Bersano A, Ballaio E et al (2009) Stem cell therapy in stroke. Cell Mol Life Sci 66(5):757\u2013772","journal-title":"Cell Mol Life Sci"},{"key":"1290_CR122","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2010.04.006","volume":"1334","author":"K Komatsu","year":"2010","unstructured":"Komatsu K, Honmou O, Suzuki J et al (2010) Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia. Brain Res 1334:84\u201392","journal-title":"Brain Res"},{"issue":"1","key":"1290_CR123","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2990.2008.00961.x","volume":"35","author":"E Keimpema","year":"2009","unstructured":"Keimpema E, Fokkens MR, Nagy Z et al (2009) Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult rats. Neuropathol Appl Neurobiol 35(1):89\u2013102","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1290_CR124","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainres.2009.11.012","volume":"1310","author":"W Zheng","year":"2010","unstructured":"Zheng W, Honmou O, Miyata K et al (2010) Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. Brain Res 1310:8\u201316","journal-title":"Brain Res"},{"issue":"1","key":"1290_CR125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ymthe.2004.09.020","volume":"11","author":"K Kurozumi","year":"2005","unstructured":"Kurozumi K, Nakamura K, Tamiya T et al (2005) Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol Ther 11(1):96\u2013104","journal-title":"Mol Ther"},{"key":"1290_CR126","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2007.11.068","volume":"1195","author":"Y Wang","year":"2008","unstructured":"Wang Y, Deng Y, Zhou GQ (2008) SDF-1alpha\/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. Brain Res 1195:104\u2013112","journal-title":"Brain Res"},{"issue":"5","key":"1290_CR127","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/jnr.22279","volume":"88","author":"K Wakabayashi","year":"2010","unstructured":"Wakabayashi K, Nagai A, Sheikh AM et al (2010) Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res 88(5):1017\u20131025","journal-title":"J Neurosci Res"},{"key":"1290_CR128","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1479-5876-8-63","volume":"8","author":"S Leu","year":"2010","unstructured":"Leu S, Lin YC, Yuen CM et al (2010) Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. J Transl Med 8:63","journal-title":"J Transl Med"},{"issue":"1","key":"1290_CR129","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.athoracsur.2005.02.072","volume":"80","author":"YL Tang","year":"2005","unstructured":"Tang YL, Zhao Q, Qin X et al (2005) Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg 80(1):229\u2013236 discussion 236-7","journal-title":"Ann Thorac Surg"},{"issue":"10","key":"1290_CR130","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1634\/stemcells.2008-0034","volume":"26","author":"A Banas","year":"2008","unstructured":"Banas A, Teratani T, Yamamoto Y et al (2008) IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells 26(10):2705\u20132712","journal-title":"Stem Cells"},{"issue":"3","key":"1290_CR131","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1469-7580.2008.00948.x","volume":"213","author":"JR Chen","year":"2008","unstructured":"Chen JR, Cheng GY, Sheu CC et al (2008) Transplanted bone marrow stromal cells migrate, differentiate and improve motor function in rats with experimentally induced cerebral stroke. J Anat 213(3):249\u2013258","journal-title":"J Anat"},{"issue":"6","key":"1290_CR132","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","volume":"57","author":"OY Bang","year":"2005","unstructured":"Bang OY, Lee JS, Lee PH et al (2005) Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57(6):874\u2013882","journal-title":"Ann Neurol"},{"issue":"6","key":"1290_CR133","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/stem.430","volume":"28","author":"JS Lee","year":"2010","unstructured":"Lee JS, Hong JM, Moon GJ et al (2010) A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 28(6):1099\u20131106","journal-title":"Stem Cells"},{"issue":"3","key":"1290_CR134","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/157488808785740352","volume":"3","author":"JK Roh","year":"2008","unstructured":"Roh JK, Jung KH, Chu K (2008) Adult stem cell transplantation in stroke: its limitations and prospects. Curr Stem Cell Res Ther 3(3):185\u2013196","journal-title":"Curr Stem Cell Res Ther"},{"issue":"8","key":"1290_CR135","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/j.1582-4934.2009.00987.x","volume":"15","author":"S Lanfranconi","year":"2011","unstructured":"Lanfranconi S, Locatelli F, Corti S et al (2011) Growth factors in ischemic stroke. J Cell Mol Med 15(8):1645\u20131687","journal-title":"J Cell Mol Med"},{"key":"1290_CR136","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1476-9255-7-51","volume":"7","author":"TL Bonfield","year":"2010","unstructured":"Bonfield TL, Nolan Koloze MT, Lennon DP et al (2010) Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond) 7:51","journal-title":"J Inflamm (Lond)"},{"issue":"6","key":"1290_CR137","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2217\/rme.10.72","volume":"5","author":"N Joyce","year":"2010","unstructured":"Joyce N, Annett G, Wirthlin L et al (2010) Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen Med 5(6):933\u2013946","journal-title":"Regen Med"},{"issue":"4","key":"1290_CR138","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2174\/157488810793351631","volume":"5","author":"EN Momin","year":"2010","unstructured":"Momin EN, Mohyeldin A, Zaidi HA et al (2010) Mesenchymal stem cells: new approaches for the treatment of neurological diseases. Curr Stem Cell Res Ther 5(4):326\u2013344","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1","key":"1290_CR139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2009.5.1.1","volume":"5","author":"PH Lee","year":"2009","unstructured":"Lee PH, Park HJ (2009) Bone marrow-derived mesenchymal stem cell therapy as a candidate disease-modifying strategy in Parkinson\u2019s disease and multiple system atrophy. J Clin Neurol 5(1):1\u201310","journal-title":"J Clin Neurol"},{"issue":"5","key":"1290_CR140","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/stem.633","volume":"29","author":"VD Roobrouck","year":"2011","unstructured":"Roobrouck VD, Clavel C, Jacobs SA et al (2011) Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions. Stem Cells 29(5):871\u2013882","journal-title":"Stem Cells"},{"issue":"3","key":"1290_CR141","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.stem.2012.02.005","volume":"10","author":"SH Ranganath","year":"2012","unstructured":"Ranganath SH, Levy O, Inamdar MS et al (2012) Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 10(3):244\u2013258","journal-title":"Cell Stem Cell"},{"issue":"1","key":"1290_CR142","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jocn.2008.05.006","volume":"16","author":"P Dharmasaroja","year":"2009","unstructured":"Dharmasaroja P (2009) Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke. J Clin Neurosci 16(1):12\u201320","journal-title":"J Clin Neurosci"},{"issue":"9","key":"1290_CR143","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1161\/STROKEAHA.107.511659","volume":"39","author":"Z Liu","year":"2008","unstructured":"Liu Z, Li Z, Zhang X et al (2008) Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment. Stroke 39(9):2571\u20132577","journal-title":"Stroke"},{"issue":"1\u20132","key":"1290_CR144","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jns.2010.09.003","volume":"298","author":"YJ Choi","year":"2010","unstructured":"Choi YJ, Li WY, Moon GJ et al (2010) Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors. J Neurol Sci 298(1\u20132):28\u201334","journal-title":"J Neurol Sci"},{"issue":"9","key":"1290_CR145","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3727\/096368908786991551","volume":"17","author":"WY Li","year":"2008","unstructured":"Li WY, Choi WJ, Lee PH et al (2008) Mesenchymal stem cells for ischemic stroke: changes in effects after ex vivo culturing. Cell Transplant 17(9):1045\u20131059","journal-title":"Cell Transplant"},{"issue":"3\u20134","key":"1290_CR146","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000233256","volume":"24","author":"FJ Rivera","year":"2009","unstructured":"Rivera FJ, Siebzehnrubi FA, Kandasamy M et al (2009) Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Cell Physiol Biochem 24(3\u20134):317\u2013324","journal-title":"Cell Physiol Biochem"},{"issue":"4","key":"1290_CR147","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.stem.2010.09.009","volume":"7","author":"K English","year":"2010","unstructured":"English K, French A, Wood KJ (2010) Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 7(4):431\u2013442","journal-title":"Cell Stem Cell"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-013-1290-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-013-1290-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-013-1290-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T16:55:26Z","timestamp":1715014526000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-013-1290-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":147,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["1290"],"URL":"https:\/\/doi.org\/10.1007\/s00018-013-1290-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}