{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:34:47Z","timestamp":1775144087497,"version":"3.50.1"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/113634\/2015"],"award-info":[{"award-number":["PD\/BD\/113634\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/DTP\/04138\/2013"],"award-info":[{"award-number":["UID\/DTP\/04138\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00018-018-2781-4","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T12:54:52Z","timestamp":1519131292000},"page":"1973-1988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins"],"prefix":"10.1007","volume":"75","author":[{"given":"In\u00eas Vieira","family":"da Silva","sequence":"first","affiliation":[]},{"given":"Joana S.","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Irene","family":"Rebelo","sequence":"additional","affiliation":[]},{"given":"Joana P. G.","family":"Miranda","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-110X","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Soveral","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"issue":"3","key":"2781_CR1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1001\/jama.287.3.356","volume":"287","author":"ES Ford","year":"2002","unstructured":"Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287(3):356\u2013359","journal-title":"JAMA"},{"issue":"9468","key":"2781_CR2","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","volume":"365","author":"RH Eckel","year":"2005","unstructured":"Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365(9468):1415\u20131428. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(05)66378-7","journal-title":"Lancet"},{"issue":"12","key":"2781_CR3","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"GM Reaven","year":"1988","unstructured":"Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37(12):1595\u20131607","journal-title":"Diabetes"},{"issue":"2","key":"2781_CR4","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ecl.2004.03.002","volume":"33","author":"G Reaven","year":"2004","unstructured":"Reaven G (2004) The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinol Metab Clin N Am 33(2):283\u2013303. \n                    https:\/\/doi.org\/10.1016\/j.ecl.2004.03.002","journal-title":"Endocrinol Metab Clin N Am"},{"issue":"2","key":"2781_CR5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/dmr.5610030204","volume":"3","author":"RA DeFronzo","year":"1987","unstructured":"DeFronzo RA, Ferrannini E (1987) Regulation of hepatic glucose metabolism in humans. Diabetes Metab Rev 3(2):415\u2013459","journal-title":"Diabetes Metab Rev"},{"issue":"9","key":"2781_CR6","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1161\/ATVBAHA.111.241463","volume":"32","author":"JD Sparks","year":"2012","unstructured":"Sparks JD, Sparks CE, Adeli K (2012) Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia. Arterioscler Thromb Vasc Biol 32(9):2104\u20132112. \n                    https:\/\/doi.org\/10.1161\/ATVBAHA.111.241463","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"2781_CR7","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1096\/fj.201601125RRR","volume":"31","author":"A Armani","year":"2017","unstructured":"Armani A, Berry A, Cirulli F, Caprio M (2017) Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte. FASEB J 31(10):4240\u20134255. \n                    https:\/\/doi.org\/10.1096\/fj.201601125RRR","journal-title":"FASEB J"},{"issue":"1","key":"2781_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ahj.2004.07.013","volume":"149","author":"PJ Miranda","year":"2005","unstructured":"Miranda PJ, DeFronzo RA, Califf RM, Guyton JR (2005) Metabolic syndrome: definition, pathophysiology, and mechanisms. Am Heart J 149(1):33\u201345. \n                    https:\/\/doi.org\/10.1016\/j.ahj.2004.07.013","journal-title":"Am Heart J"},{"issue":"3","key":"2781_CR9","doi-asserted-by":"publisher","first-page":"F271","DOI":"10.1152\/ajprenal.1980.239.3.F271","volume":"239","author":"JE Hall","year":"1980","unstructured":"Hall JE, Guyton AC, Smith MJ Jr, Coleman TG (1980) Blood pressure and renal function during chronic changes in sodium intake: role of angiotensin. Am J Physiol 239(3):F271\u2013F280. \n                    https:\/\/doi.org\/10.1152\/ajprenal.1980.239.3.F271","journal-title":"Am J Physiol"},{"issue":"6 Pt 2","key":"2781_CR10","doi-asserted-by":"publisher","first-page":"116S","DOI":"10.1016\/S0895-7061(01)02078-7","volume":"14","author":"BM Egan","year":"2001","unstructured":"Egan BM, Greene EL, Goodfriend TL (2001) Insulin resistance and cardiovascular disease. Am J Hypertens 14(6 Pt 2):116S\u2013125S","journal-title":"Am J Hypertens"},{"issue":"5","key":"2781_CR11","doi-asserted-by":"publisher","first-page":"H1597","DOI":"10.1152\/ajpheart.00026.2004","volume":"286","author":"JR Sowers","year":"2004","unstructured":"Sowers JR (2004) Insulin resistance and hypertension. Am J Physiol Heart Circ Physiol 286(5):H1597\u2013H1602. \n                    https:\/\/doi.org\/10.1152\/ajpheart.00026.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2781_CR12","doi-asserted-by":"publisher","first-page":"391762","DOI":"10.4061\/2011\/391762","volume":"2011","author":"S Horita","year":"2011","unstructured":"Horita S, Seki G, Yamada H, Suzuki M, Koike K, Fujita T (2011) Insulin resistance, obesity, hypertension, and renal sodium transport. Int J Hypertens 2011:391762. \n                    https:\/\/doi.org\/10.4061\/2011\/391762","journal-title":"Int J Hypertens"},{"key":"2781_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.med.48.1.307","volume":"48","author":"BB Lowell","year":"1997","unstructured":"Lowell BB, Flier JS (1997) Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med 48:307\u2013316. \n                    https:\/\/doi.org\/10.1146\/annurev.med.48.1.307","journal-title":"Annu Rev Med"},{"issue":"2","key":"2781_CR14","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","volume":"150","author":"J Wu","year":"2012","unstructured":"Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerback S, Schrauwen P, Spiegelman BM (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150(2):366\u2013376. \n                    https:\/\/doi.org\/10.1016\/j.cell.2012.05.016","journal-title":"Cell"},{"issue":"1","key":"2781_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000321319","volume":"58","author":"CH Saely","year":"2012","unstructured":"Saely CH, Geiger K, Drexel H (2012) Brown versus white adipose tissue: a mini-review. Gerontology 58(1):15\u201323. \n                    https:\/\/doi.org\/10.1159\/000321319","journal-title":"Gerontology"},{"issue":"3","key":"2781_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.tem.2008.11.005","volume":"20","author":"MI Lefterova","year":"2009","unstructured":"Lefterova MI, Lazar MA (2009) New developments in adipogenesis. Trends Endocrinol Metab TEM 20(3):107\u2013114. \n                    https:\/\/doi.org\/10.1016\/j.tem.2008.11.005","journal-title":"Trends Endocrinol Metab TEM"},{"issue":"2","key":"2781_CR17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0300-595X(76)80023-0","volume":"5","author":"J Hirsch","year":"1976","unstructured":"Hirsch J, Batchelor B (1976) Adipose tissue cellularity in human obesity. Clin Endocrinol Metab 5(2):299\u2013311","journal-title":"Clin Endocrinol Metab"},{"issue":"10","key":"2781_CR18","doi-asserted-by":"publisher","first-page":"E1870","DOI":"10.1210\/jc.2014-1526","volume":"99","author":"M Ryden","year":"2014","unstructured":"Ryden M, Andersson DP, Bergstrom IB, Arner P (2014) Adipose tissue and metabolic alterations: regional differences in fat cell size and number matter, but differently: a cross-sectional study. J Clin Endocrinol Metab 99(10):E1870\u2013E1876. \n                    https:\/\/doi.org\/10.1210\/jc.2014-1526","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2781_CR19","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/oby.21377","volume":"24","author":"LA Muir","year":"2016","unstructured":"Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, Varban OA, Finks JF, Zamarron BF, Flesher CG, Chang JS, DelProposto JB, Geletka L, Martinez-Santibanez G, Kaciroti N, Lumeng CN, O\u2019Rourke RW (2016) Adipose tissue fibrosis, hypertrophy, and hyperplasia: correlations with diabetes in human obesity. Obesity (Silver Spring) 24(3):597\u2013605. \n                    https:\/\/doi.org\/10.1002\/oby.21377","journal-title":"Obesity (Silver Spring)"},{"issue":"3","key":"2781_CR20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bbadis.2013.06.003","volume":"1842","author":"S Corvera","year":"2014","unstructured":"Corvera S, Gealekman O (2014) Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochem Biophys Acta 1842(3):463\u2013472. \n                    https:\/\/doi.org\/10.1016\/j.bbadis.2013.06.003","journal-title":"Biochem Biophys Acta"},{"issue":"5901","key":"2781_CR21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1126\/science.1156232","volume":"322","author":"W Tang","year":"2008","unstructured":"Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM (2008) White fat progenitor cells reside in the adipose vasculature. Science 322(5901):583\u2013586. \n                    https:\/\/doi.org\/10.1126\/science.1156232","journal-title":"Science"},{"issue":"8","key":"2781_CR22","doi-asserted-by":"publisher","first-page":"E691","DOI":"10.1152\/ajpendo.00297.2015","volume":"309","author":"A Rodriguez","year":"2015","unstructured":"Rodriguez A, Ezquerro S, Mendez-Gimenez L, Becerril S, Fruhbeck G (2015) Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. Am J Physiol Endocrinol Metab 309(8):E691\u2013E714. \n                    https:\/\/doi.org\/10.1152\/ajpendo.00297.2015","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"7642","key":"2781_CR23","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/nature21365","volume":"542","author":"T Thomou","year":"2017","unstructured":"Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR (2017) Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature 542(7642):450\u2013455. \n                    https:\/\/doi.org\/10.1038\/nature21365","journal-title":"Nature"},{"issue":"21","key":"2781_CR24","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.2174\/138161207781039599","volume":"13","author":"A Rodriguez","year":"2007","unstructured":"Rodriguez A, Catalan V, Gomez-Ambrosi J, Fruhbeck G (2007) Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des 13(21):2169\u20132175","journal-title":"Curr Pharm Des"},{"issue":"2","key":"2781_CR25","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/nu5020498","volume":"5","author":"JO Ebbert","year":"2013","unstructured":"Ebbert JO, Jensen MD (2013) Fat depots, free fatty acids, and dyslipidemia. Nutrients 5(2):498\u2013508. \n                    https:\/\/doi.org\/10.3390\/nu5020498","journal-title":"Nutrients"},{"key":"2781_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-94-024-1057-0_15","volume":"969","author":"IV Silva da","year":"2017","unstructured":"da Silva IV, Soveral G (2017) Aquaporins in obesity. Adv Exp Med Biol 969:227\u2013238. \n                    https:\/\/doi.org\/10.1007\/978-94-024-1057-0_15","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"2781_CR27","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","volume":"1801","author":"S Virtue","year":"2010","unstructured":"Virtue S, Vidal-Puig A (2010) Adipose tissue expandability, lipotoxicity and the metabolic syndrome\u2014an allostatic perspective. Biochem Biophys Acta 1801(3):338\u2013349. \n                    https:\/\/doi.org\/10.1016\/j.bbalip.2009.12.006","journal-title":"Biochem Biophys Acta"},{"issue":"4","key":"2781_CR28","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.ecl.2008.09.002","volume":"37","author":"C Lara-Castro","year":"2008","unstructured":"Lara-Castro C, Garvey WT (2008) Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome. Endocrinol Metab Clin N Am 37(4):841\u2013856. \n                    https:\/\/doi.org\/10.1016\/j.ecl.2008.09.002","journal-title":"Endocrinol Metab Clin N Am"},{"issue":"2","key":"2781_CR29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1023\/B:REMD.0000021434.98627.dc","volume":"5","author":"M Krssak","year":"2004","unstructured":"Krssak M, Roden M (2004) The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans. Rev Endocr Metab Disord 5(2):127\u2013134. \n                    https:\/\/doi.org\/10.1023\/B:REMD.0000021434.98627.dc","journal-title":"Rev Endocr Metab Disord"},{"issue":"11","key":"2781_CR30","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/eci.12519","volume":"45","author":"SM Grundy","year":"2015","unstructured":"Grundy SM (2015) Adipose tissue and metabolic syndrome: too much, too little or neither. Eur J Clin Investig 45(11):1209\u20131217. \n                    https:\/\/doi.org\/10.1111\/eci.12519","journal-title":"Eur J Clin Investig"},{"issue":"9","key":"2781_CR31","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1371\/journal.pbio.0060237","volume":"6","author":"S Virtue","year":"2008","unstructured":"Virtue S, Vidal-Puig A (2008) It\u2019s not how fat you are, it\u2019s what you do with it that counts. PLoS Biol 6(9):e237. \n                    https:\/\/doi.org\/10.1371\/journal.pbio.0060237","journal-title":"PLoS Biol"},{"issue":"4","key":"2781_CR32","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/apha.12246","volume":"210","author":"T Romacho","year":"2014","unstructured":"Romacho T, Elsen M, Rohrborn D, Eckel J (2014) Adipose tissue and its role in organ crosstalk. Acta Physiol (Oxf) 210(4):733\u2013753. \n                    https:\/\/doi.org\/10.1111\/apha.12246","journal-title":"Acta Physiol (Oxf)"},{"issue":"Pt 5","key":"2781_CR33","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1042\/BST20051078","volume":"33","author":"P Trayhurn","year":"2005","unstructured":"Trayhurn P, Wood IS (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33(Pt 5):1078\u20131081. \n                    https:\/\/doi.org\/10.1042\/BST20051078","journal-title":"Biochem Soc Trans"},{"key":"2781_CR34","volume-title":"The Continuum of Health Risk Assessement","author":"G Mazzoleni","year":"2012","unstructured":"Mazzoleni G, Steimberg N (2012) New models for the in vitro study of liver toxicity: 3D culture systems and the role of bioreactors. In: Tyshenko MG (ed) The Continuum of Health Risk Assessement. InTechOpen, Croatia. ISBN:980-953-307-582-7"},{"issue":"1","key":"2781_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/cphy.c130024","volume":"4","author":"L Rui","year":"2014","unstructured":"Rui L (2014) Energy metabolism in the liver. Compr Physiol 4(1):177\u2013197. \n                    https:\/\/doi.org\/10.1002\/cphy.c130024","journal-title":"Compr Physiol"},{"issue":"2","key":"2781_CR36","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1152\/physrev.00025.2005","volume":"86","author":"B Desvergne","year":"2006","unstructured":"Desvergne B, Michalik L, Wahli W (2006) Transcriptional regulation of metabolism. Physiol Rev 86(2):465\u2013514. \n                    https:\/\/doi.org\/10.1152\/physrev.00025.2005","journal-title":"Physiol Rev"},{"issue":"4","key":"2781_CR37","doi-asserted-by":"publisher","first-page":"E671","DOI":"10.1152\/ajpendo.00492.2002","volume":"284","author":"G Jiang","year":"2003","unstructured":"Jiang G, Zhang BB (2003) Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab 284(4):E671\u2013E678. \n                    https:\/\/doi.org\/10.1152\/ajpendo.00492.2002","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"13\u201314","key":"2781_CR38","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.clinbiochem.2009.05.018","volume":"42","author":"R Meshkani","year":"2009","unstructured":"Meshkani R, Adeli K (2009) Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem 42(13\u201314):1331\u20131346. \n                    https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.05.018","journal-title":"Clin Biochem"},{"issue":"1","key":"2781_CR39","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","volume":"6","author":"MD Michael","year":"2000","unstructured":"Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6(1):87\u201397","journal-title":"Mol Cell"},{"issue":"5","key":"2781_CR40","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S1097-2765(00)80155-0","volume":"2","author":"JC Bruning","year":"1998","unstructured":"Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ, Kahn CR (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2(5):559\u2013569","journal-title":"Mol Cell"},{"issue":"1","key":"2781_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S1097-2765(05)00010-9","volume":"6","author":"I Shimomura","year":"2000","unstructured":"Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob\/ob mice. Mol Cell 6(1):77\u201386","journal-title":"Mol Cell"},{"issue":"6","key":"2781_CR42","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/BF01220632","volume":"12","author":"AH Kissebah","year":"1976","unstructured":"Kissebah AH, Alfarsi S, Adams PW, Wynn V (1976) Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man. Diabetologia 12(6):563\u2013571","journal-title":"Diabetologia"},{"issue":"3","key":"2781_CR43","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1124\/pr.109.001560","volume":"61","author":"E Ehrenborg","year":"2009","unstructured":"Ehrenborg E, Krook A (2009) Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta. Pharmacol Rev 61(3):373\u2013393. \n                    https:\/\/doi.org\/10.1124\/pr.109.001560","journal-title":"Pharmacol Rev"},{"issue":"6","key":"2781_CR44","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1172\/JCI110399","volume":"68","author":"RA DeFronzo","year":"1981","unstructured":"DeFronzo RA, Ferrannini E, Sato Y, Felig P, Wahren J (1981) Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Investig 68(6):1468\u20131474","journal-title":"J Clin Investig"},{"issue":"4","key":"2781_CR45","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1056\/NEJM199001253220403","volume":"322","author":"GI Shulman","year":"1990","unstructured":"Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG (1990) Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322(4):223\u2013228. \n                    https:\/\/doi.org\/10.1056\/NEJM199001253220403","journal-title":"N Engl J Med"},{"key":"2781_CR46","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fphys.2011.00112","volume":"2","author":"J Jensen","year":"2011","unstructured":"Jensen J, Rustad PI, Kolnes AJ, Lai YC (2011) The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol 2:112. \n                    https:\/\/doi.org\/10.3389\/fphys.2011.00112","journal-title":"Front Physiol"},{"key":"2781_CR47","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1146\/annurev.ph.49.030187.003325","volume":"49","author":"E Homsher","year":"1987","unstructured":"Homsher E (1987) Muscle enthalpy production and its relationship to actomyosin ATPase. Annu Rev Physiol 49:673\u2013690. \n                    https:\/\/doi.org\/10.1146\/annurev.ph.49.030187.003325","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"2781_CR48","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","volume":"582","author":"C Luca de","year":"2008","unstructured":"de Luca C, Olefsky JM (2008) Inflammation and insulin resistance. FEBS Lett 582(1):97\u2013105. \n                    https:\/\/doi.org\/10.1016\/j.febslet.2007.11.057","journal-title":"FEBS Lett"},{"key":"2781_CR49","doi-asserted-by":"publisher","first-page":"476279","DOI":"10.1155\/2010\/476279","volume":"2010","author":"MA Abdul-Ghani","year":"2010","unstructured":"Abdul-Ghani MA, DeFronzo RA (2010) Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol 2010:476279. \n                    https:\/\/doi.org\/10.1155\/2010\/476279","journal-title":"J Biomed Biotechnol"},{"issue":"52","key":"2781_CR50","doi-asserted-by":"publisher","first-page":"50230","DOI":"10.1074\/jbc.M200958200","volume":"277","author":"C Yu","year":"2002","unstructured":"Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277(52):50230\u201350236. \n                    https:\/\/doi.org\/10.1074\/jbc.M200958200","journal-title":"J Biol Chem"},{"issue":"1","key":"2781_CR51","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1172\/JCI111938","volume":"76","author":"RA DeFronzo","year":"1985","unstructured":"DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Investig 76(1):149\u2013155. \n                    https:\/\/doi.org\/10.1172\/JCI111938","journal-title":"J Clin Investig"},{"issue":"6 Pt 1","key":"2781_CR52","first-page":"E1130","volume":"277","author":"DE Kelley","year":"1999","unstructured":"Kelley DE, Goodpaster B, Wing RR, Simoneau JA (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277(6 Pt 1):E1130\u2013E1141","journal-title":"Am J Physiol"},{"issue":"5","key":"2781_CR53","doi-asserted-by":"publisher","first-page":"e154","DOI":"10.1371\/journal.pmed.0040154","volume":"4","author":"J Szendroedi","year":"2007","unstructured":"Szendroedi J, Schmid AI, Chmelik M, Toth C, Brehm A, Krssak M, Nowotny P, Wolzt M, Waldhausl W, Roden M (2007) Muscle mitochondrial ATP synthesis and glucose transport\/phosphorylation in type 2 diabetes. PLoS Med 4(5):e154. \n                    https:\/\/doi.org\/10.1371\/journal.pmed.0040154","journal-title":"PLoS Med"},{"issue":"6","key":"2781_CR54","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.2337\/db06-0981","volume":"56","author":"M Mogensen","year":"2007","unstructured":"Mogensen M, Sahlin K, Fernstrom M, Glintborg D, Vind BF, Beck-Nielsen H, Hojlund K (2007) Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes 56(6):1592\u20131599. \n                    https:\/\/doi.org\/10.2337\/db06-0981","journal-title":"Diabetes"},{"issue":"9","key":"2781_CR55","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/nrm1469","volume":"5","author":"LS King","year":"2004","unstructured":"King LS, Kozono D, Agre P (2004) From structure to disease: the evolving tale of aquaporin biology. Nat Rev Mol Cell Biol 5(9):687\u2013698. \n                    https:\/\/doi.org\/10.1038\/nrm1469","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"33","key":"2781_CR56","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1002\/anie.200460804","volume":"43","author":"P Agre","year":"2004","unstructured":"Agre P (2004) Aquaporin water channels (Nobel Lecture). Angew Chem Int Ed Engl 43(33):4278\u20134290. \n                    https:\/\/doi.org\/10.1002\/anie.200460804","journal-title":"Angew Chem Int Ed Engl"},{"key":"2781_CR57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-540-79885-9_1","volume":"190","author":"JM Carbrey","year":"2009","unstructured":"Carbrey JM, Agre P (2009) Discovery of the aquaporins and development of the field. Handb Exp Pharmacol 190:3\u201328. \n                    https:\/\/doi.org\/10.1007\/978-3-540-79885-9_1","journal-title":"Handb Exp Pharmacol"},{"issue":"4","key":"2781_CR58","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1745-7254.2006.00318.x","volume":"27","author":"F Wang","year":"2006","unstructured":"Wang F, Feng XC, Li YM, Yang H, Ma TH (2006) Aquaporins as potential drug targets. Acta Pharmacol Sin 27(4):395\u2013401. \n                    https:\/\/doi.org\/10.1111\/j.1745-7254.2006.00318.x","journal-title":"Acta Pharmacol Sin"},{"issue":"20","key":"2781_CR59","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.1002\/pmic.200600212","volume":"6","author":"F Magni","year":"2006","unstructured":"Magni F, Sarto C, Ticozzi D, Soldi M, Bosso N, Mocarelli P, Kienle MG (2006) Proteomic knowledge of human aquaporins. Proteomics 6(20):5637\u20135649. \n                    https:\/\/doi.org\/10.1002\/pmic.200600212","journal-title":"Proteomics"},{"issue":"1","key":"2781_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.proghi.2004.03.001","volume":"39","author":"K Takata","year":"2004","unstructured":"Takata K, Matsuzaki T, Tajika Y (2004) Aquaporins: water channel proteins of the cell membrane. Prog Histochem Cytochem 39(1):1\u201383","journal-title":"Prog Histochem Cytochem"},{"issue":"5","key":"2781_CR61","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/j.bbagen.2013.10.039","volume":"1840","author":"K Ishibashi","year":"2014","unstructured":"Ishibashi K, Tanaka Y, Morishita Y (2014) The role of mammalian superaquaporins inside the cell. Biochem Biophys Acta 1840(5):1507\u20131512. \n                    https:\/\/doi.org\/10.1016\/j.bbagen.2013.10.039","journal-title":"Biochem Biophys Acta"},{"issue":"6138","key":"2781_CR62","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1126\/science.1234306","volume":"340","author":"UK Eriksson","year":"2013","unstructured":"Eriksson UK, Fischer G, Friemann R, Enkavi G, Tajkhorshid E, Neutze R (2013) Subangstrom resolution X-ray structure details aquaporin\u2013water interactions. Science 340(6138):1346\u20131349. \n                    https:\/\/doi.org\/10.1126\/science.1234306","journal-title":"Science"},{"issue":"6866","key":"2781_CR63","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/414872a","volume":"414","author":"H Sui","year":"2001","unstructured":"Sui H, Han BG, Lee JK, Walian P, Jap BK (2001) Structural basis of water-specific transport through the AQP1 water channel. Nature 414(6866):872\u2013878. \n                    https:\/\/doi.org\/10.1038\/414872a","journal-title":"Nature"},{"issue":"15","key":"2781_CR64","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1038\/emboj.2009.182","volume":"28","author":"B Wu","year":"2009","unstructured":"Wu B, Steinbronn C, Alsterfjord M, Zeuthen T, Beitz E (2009) Concerted action of two cation filters in the aquaporin water channel. EMBO J 28(15):2188\u20132194. \n                    https:\/\/doi.org\/10.1038\/emboj.2009.182","journal-title":"EMBO J"},{"issue":"2","key":"2781_CR65","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jmb.2003.08.003","volume":"333","author":"BL Groot de","year":"2003","unstructured":"de Groot BL, Frigato T, Helms V, Grubmuller H (2003) The mechanism of proton exclusion in the aquaporin-1 water channel. J Mol Biol 333(2):279\u2013293","journal-title":"J Mol Biol"},{"issue":"Pt 13","key":"2781_CR66","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1242\/jcs.079467","volume":"124","author":"AS Verkman","year":"2011","unstructured":"Verkman AS (2011) Aquaporins at a glance. J Cell Sci 124(Pt 13):2107\u20132112. \n                    https:\/\/doi.org\/10.1242\/jcs.079467","journal-title":"J Cell Sci"},{"issue":"4","key":"2781_CR67","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrd4226","volume":"13","author":"AS Verkman","year":"2014","unstructured":"Verkman AS, Anderson MO, Papadopoulos MC (2014) Aquaporins: important but elusive drug targets. Nat Rev Drug Discov 13(4):259\u2013277. \n                    https:\/\/doi.org\/10.1038\/nrd4226","journal-title":"Nat Rev Drug Discov"},{"key":"2781_CR68","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.pharmthera.2015.08.002","volume":"155","author":"E Beitz","year":"2015","unstructured":"Beitz E, Golldack A, Rothert M, von Bulow J (2015) Challenges and achievements in the therapeutic modulation of aquaporin functionality. Pharmacol Ther 155:22\u201335. \n                    https:\/\/doi.org\/10.1016\/j.pharmthera.2015.08.002","journal-title":"Pharmacol Ther"},{"key":"2781_CR69","doi-asserted-by":"publisher","DOI":"10.1201\/b19017","volume-title":"Aquaporins in health and disease: new molecular targets for drug discovery","author":"G Soveral","year":"2016","unstructured":"Soveral G, Nielsen S, Casini A (2016) Aquaporins in health and disease: new molecular targets for drug discovery. CRC Press, Taylor & Francis Group, Boca Raton"},{"issue":"1","key":"2781_CR70","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/13543776.2017.1236085","volume":"27","author":"G Soveral","year":"2017","unstructured":"Soveral G, Casini A (2017) Aquaporin modulators: a patent review (2010\u20132015). Expert Opin Ther Pat 27(1):49\u201362. \n                    https:\/\/doi.org\/10.1080\/13543776.2017.1236085","journal-title":"Expert Opin Ther Pat"},{"issue":"19","key":"2781_CR71","doi-asserted-by":"publisher","first-page":"17147","DOI":"10.1074\/jbc.M200925200","volume":"277","author":"T Ma","year":"2002","unstructured":"Ma T, Hara M, Sougrat R, Verbavatz JM, Verkman AS (2002) Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J Biol Chem 277(19):17147\u201317153. \n                    https:\/\/doi.org\/10.1074\/jbc.M200925200","journal-title":"J Biol Chem"},{"issue":"31","key":"2781_CR72","doi-asserted-by":"publisher","first-page":"10993","DOI":"10.1073\/pnas.0503291102","volume":"102","author":"T Hibuse","year":"2005","unstructured":"Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura I (2005) Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci USA 102(31):10993\u201310998. \n                    https:\/\/doi.org\/10.1073\/pnas.0503291102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2781_CR73","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/bies.1073","volume":"23","author":"D Brisson","year":"2001","unstructured":"Brisson D, Vohl MC, St-Pierre J, Hudson TJ, Gaudet D (2001) Glycerol: a neglected variable in metabolic processes? BioEssays News Rev Mol Cell Dev Biol 23(6):534\u2013542. \n                    https:\/\/doi.org\/10.1002\/bies.1073","journal-title":"BioEssays News Rev Mol Cell Dev Biol"},{"issue":"10","key":"2781_CR74","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.4161\/cc.10.10.15672","volume":"10","author":"A Rodriguez","year":"2011","unstructured":"Rodriguez A, Catalan V, Gomez-Ambrosi J, Fruhbeck G (2011) Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle 10(10):1548\u20131556","journal-title":"Cell Cycle"},{"issue":"1","key":"2781_CR75","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1093\/cvr\/cvp095","volume":"83","author":"T Hibuse","year":"2009","unstructured":"Hibuse T, Maeda N, Nakatsuji H, Tochino Y, Fujita K, Kihara S, Funahashi T, Shimomura I (2009) The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator. Cardiovasc Res 83(1):34\u201341. \n                    https:\/\/doi.org\/10.1093\/cvr\/cvp095","journal-title":"Cardiovasc Res"},{"key":"2781_CR76","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.nutr.27.061406.093734","volume":"27","author":"RE Duncan","year":"2007","unstructured":"Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS (2007) Regulation of lipolysis in adipocytes. Annu Rev Nutr 27:79\u2013101. \n                    https:\/\/doi.org\/10.1146\/annurev.nutr.27.061406.093734","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"2781_CR77","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1017\/S095442241400002X","volume":"27","author":"G Fruhbeck","year":"2014","unstructured":"Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A (2014) Regulation of adipocyte lipolysis. Nutr Res Rev 27(1):63\u201393. \n                    https:\/\/doi.org\/10.1017\/S095442241400002X","journal-title":"Nutr Res Rev"},{"issue":"8","key":"2781_CR78","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.bbamem.2006.01.008","volume":"1758","author":"T Hibuse","year":"2006","unstructured":"Hibuse T, Maeda N, Nagasawa A, Funahashi T (2006) Aquaporins and glycerol metabolism. Biochem Biophys Acta 1758(8):1004\u20131011. \n                    https:\/\/doi.org\/10.1016\/j.bbamem.2006.01.008","journal-title":"Biochem Biophys Acta"},{"issue":"4","key":"2781_CR79","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00018-014-1773-2","volume":"72","author":"A Madeira","year":"2015","unstructured":"Madeira A, Moura TF, Soveral G (2015) Aquaglyceroporins: implications in adipose biology and obesity. Cell Mol Life Sci 72(4):759\u2013771. \n                    https:\/\/doi.org\/10.1007\/s00018-014-1773-2","journal-title":"Cell Mol Life Sci"},{"issue":"27","key":"2781_CR80","doi-asserted-by":"publisher","first-page":"20896","DOI":"10.1074\/jbc.M001119200","volume":"275","author":"K Kishida","year":"2000","unstructured":"Kishida K, Kuriyama H, Funahashi T, Shimomura I, Kihara S, Ouchi N, Nishida M, Nishizawa H, Matsuda M, Takahashi M, Hotta K, Nakamura T, Yamashita S, Tochino Y, Matsuzawa Y (2000) Aquaporin adipose, a putative glycerol channel in adipocytes. J Biol Chem 275(27):20896\u201320902. \n                    https:\/\/doi.org\/10.1074\/jbc.M001119200","journal-title":"J Biol Chem"},{"issue":"7","key":"2781_CR81","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1210\/jc.2009-2655","volume":"95","author":"M Miranda","year":"2010","unstructured":"Miranda M, Escote X, Ceperuelo-Mallafre V, Alcaide MJ, Simon I, Vilarrasa N, Wabitsch M, Vendrell J (2010) Paired subcutaneous and visceral adipose tissue aquaporin-7 expression in human obesity and type 2 diabetes: differences and similarities between depots. J Clin Endocrinol Metab 95(7):3470\u20133479. \n                    https:\/\/doi.org\/10.1210\/jc.2009-2655","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2781_CR82","doi-asserted-by":"publisher","first-page":"e54474","DOI":"10.1371\/journal.pone.0054474","volume":"8","author":"U Laforenza","year":"2013","unstructured":"Laforenza U, Scaffino MF, Gastaldi G (2013) Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. PLoS One 8(1):e54474. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0054474","journal-title":"PLoS One"},{"issue":"16","key":"2781_CR83","doi-asserted-by":"publisher","first-page":"15493","DOI":"10.1074\/jbc.C500028200","volume":"280","author":"M Hara-Chikuma","year":"2005","unstructured":"Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS (2005) Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem 280(16):15493\u201315496. \n                    https:\/\/doi.org\/10.1074\/jbc.C500028200","journal-title":"J Biol Chem"},{"issue":"9","key":"2781_CR84","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1002\/oby.20792","volume":"22","author":"A Madeira","year":"2014","unstructured":"Madeira A, Fernandez-Veledo S, Camps M, Zorzano A, Moura TF, Ceperuelo-Mallafre V, Vendrell J, Soveral G (2014) Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes. Obesity (Silver Spring) 22(9):2010\u20132017. \n                    https:\/\/doi.org\/10.1002\/oby.20792","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"2781_CR85","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00395-013-0393-6","volume":"108","author":"A Rutkovskiy","year":"2013","unstructured":"Rutkovskiy A, Valen G, Vaage J (2013) Cardiac aquaporins. Basic Res Cardiol 108(6):393. \n                    https:\/\/doi.org\/10.1007\/s00395-013-0393-6","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"2781_CR86","doi-asserted-by":"publisher","first-page":"H705","DOI":"10.1152\/ajpheart.00090.2006","volume":"291","author":"TL Butler","year":"2006","unstructured":"Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, Winlaw DS (2006) Cardiac aquaporin expression in humans, rats, and mice. Am J Physiol Heart Circ Physiol 291(2):H705\u2013H713. \n                    https:\/\/doi.org\/10.1152\/ajpheart.00090.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"2781_CR87","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/cvr\/cvp147","volume":"83","author":"M Gladka","year":"2009","unstructured":"Gladka M, El Azzouzi H, De Windt LJ, da Costa Martins PA (2009) Aquaporin 7: the glycerol aquaeductus in the heart. Cardiovasc Res 83(1):3\u20134. \n                    https:\/\/doi.org\/10.1093\/cvr\/cvp147","journal-title":"Cardiovasc Res"},{"issue":"9","key":"2781_CR88","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1073\/pnas.0610894104","volume":"104","author":"AM Rojek","year":"2007","unstructured":"Rojek AM, Skowronski MT, Fuchtbauer EM, Fuchtbauer AC, Fenton RA, Agre P, Frokiaer J, Nielsen S (2007) Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci USA 104(9):3609\u20133614. \n                    https:\/\/doi.org\/10.1073\/pnas.0610894104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4\u20136","key":"2781_CR89","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1159\/000218172","volume":"23","author":"L Best","year":"2009","unstructured":"Best L, Brown PD, Yates AP, Perret J, Virreira M, Beauwens R, Malaisse WJ, Sener A, Delporte C (2009) Contrasting effects of glycerol and urea transport on rat pancreatic beta-cell function. Cell Physiol Biochem 23(4\u20136):255\u2013264. \n                    https:\/\/doi.org\/10.1159\/000218172","journal-title":"Cell Physiol Biochem"},{"issue":"1\u20132","key":"2781_CR90","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000337588","volume":"29","author":"K Louchami","year":"2012","unstructured":"Louchami K, Best L, Brown P, Virreira M, Hupkens E, Perret J, Devuyst O, Uchida S, Delporte C, Malaisse WJ, Beauwens R, Sener A (2012) A new role for aquaporin 7 in insulin secretion. Cell Physiol Biochem 29(1\u20132):65\u201374. \n                    https:\/\/doi.org\/10.1159\/000337588","journal-title":"Cell Physiol Biochem"},{"key":"2781_CR91","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev.physiol.70.113006.100452","volume":"70","author":"A Rojek","year":"2008","unstructured":"Rojek A, Praetorius J, Frokiaer J, Nielsen S, Fenton RA (2008) A current view of the mammalian aquaglyceroporins. Annu Rev Physiol 70:301\u2013327. \n                    https:\/\/doi.org\/10.1146\/annurev.physiol.70.113006.100452","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"2781_CR92","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1006\/bbrc.1997.7769","volume":"241","author":"H Kuriyama","year":"1997","unstructured":"Kuriyama H, Kawamoto S, Ishida N, Ohno I, Mita S, Matsuzawa Y, Matsubara K, Okubo K (1997) Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. Biochem Biophys Res Commun 241(1):53\u201358. \n                    https:\/\/doi.org\/10.1006\/bbrc.1997.7769","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2781_CR93","first-page":"62","volume":"1399","author":"K Ishibashi","year":"1998","unstructured":"Ishibashi K, Yamauchi K, Kageyama Y, Saito-Ohara F, Ikeuchi T, Marumo F, Sasaki S (1998) Molecular characterization of human aquaporin-7 gene and its chromosomal mapping. Biochem Biophys Acta 1399(1):62\u201366","journal-title":"Biochem Biophys Acta"},{"issue":"5","key":"2781_CR94","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.febslet.2015.01.025","volume":"589","author":"T Miyauchi","year":"2015","unstructured":"Miyauchi T, Yamamoto H, Abe Y, Yoshida GJ, Rojek A, Sohara E, Uchida S, Nielsen S, Yasui M (2015) Dynamic subcellular localization of aquaporin-7 in white adipocytes. FEBS Lett 589(5):608\u2013614. \n                    https:\/\/doi.org\/10.1016\/j.febslet.2015.01.025","journal-title":"FEBS Lett"},{"issue":"Suppl 1","key":"2781_CR95","doi-asserted-by":"publisher","first-page":"S215","DOI":"10.1007\/s00592-012-0430-1","volume":"49","author":"J Lebeck","year":"2012","unstructured":"Lebeck J, Ostergard T, Rojek A, Fuchtbauer EM, Lund S, Nielsen S, Praetorius J (2012) Gender-specific effect of physical training on AQP7 protein expression in human adipose tissue. Acta Diabetol 49(Suppl 1):S215\u2013S226. \n                    https:\/\/doi.org\/10.1007\/s00592-012-0430-1","journal-title":"Acta Diabetol"},{"issue":"3","key":"2781_CR96","doi-asserted-by":"publisher","first-page":"F956","DOI":"10.1152\/ajprenal.00314.2006","volume":"292","author":"MT Skowronski","year":"2007","unstructured":"Skowronski MT, Lebeck J, Rojek A, Praetorius J, Fuchtbauer EM, Frokiaer J, Nielsen S (2007) AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Renal Physiol 292(3):F956\u2013F965. \n                    https:\/\/doi.org\/10.1152\/ajprenal.00314.2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"2781_CR97","doi-asserted-by":"publisher","first-page":"e83442","DOI":"10.1371\/journal.pone.0083442","volume":"8","author":"A Madeira","year":"2013","unstructured":"Madeira A, Camps M, Zorzano A, Moura TF, Soveral G (2013) Biophysical assessment of human aquaporin-7 as a water and glycerol channel in 3T3-L1 adipocytes. PLoS One 8(12):e83442. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0083442","journal-title":"PLoS One"},{"issue":"4","key":"2781_CR98","doi-asserted-by":"publisher","first-page":"E586","DOI":"10.1210\/jc.2010-1408","volume":"96","author":"A Rodriguez","year":"2011","unstructured":"Rodriguez A, Catalan V, Gomez-Ambrosi J, Garcia-Navarro S, Rotellar F, Valenti V, Silva C, Gil MJ, Salvador J, Burrell MA, Calamita G, Malagon MM, Fruhbeck G (2011) Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K\/Akt\/mTOR signaling cascade. J Clin Endocrinol Metab 96(4):E586\u2013E597. \n                    https:\/\/doi.org\/10.1210\/jc.2010-1408","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2781_CR99","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.metabol.2005.04.015","volume":"54","author":"DH Lee","year":"2005","unstructured":"Lee DH, Park DB, Lee YK, An CS, Oh YS, Kang JS, Kang SH, Chung MY (2005) The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats. Metabolism 54(10):1282\u20131289. \n                    https:\/\/doi.org\/10.1016\/j.metabol.2005.04.015","journal-title":"Metabolism"},{"issue":"17","key":"2781_CR100","doi-asserted-by":"publisher","first-page":"6026","DOI":"10.1128\/MCB.00384-07","volume":"27","author":"K Matsumura","year":"2007","unstructured":"Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L (2007) Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol 27(17):6026\u20136037. \n                    https:\/\/doi.org\/10.1128\/MCB.00384-07","journal-title":"Mol Cell Biol"},{"issue":"9","key":"2781_CR101","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1210\/jc.2007-0531","volume":"92","author":"V Ceperuelo-Mallafre","year":"2007","unstructured":"Ceperuelo-Mallafre V, Miranda M, Chacon MR, Vilarrasa N, Megia A, Gutierrez C, Fernandez-Real JM, Gomez JM, Caubet E, Fruhbeck G, Vendrell J (2007) Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. J Clin Endocrinol Metab 92(9):3640\u20133645. \n                    https:\/\/doi.org\/10.1210\/jc.2007-0531","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2781_CR102","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1086\/338629","volume":"70","author":"CM Lindgren","year":"2002","unstructured":"Lindgren CM, Mahtani MM, Widen E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, Lander ES (2002) Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. Am J Hum Genet 70(2):509\u2013516. \n                    https:\/\/doi.org\/10.1086\/338629","journal-title":"Am J Hum Genet"},{"issue":"12","key":"2781_CR103","doi-asserted-by":"publisher","first-page":"5935","DOI":"10.1210\/jc.2003-030553","volume":"88","author":"RJ Loos","year":"2003","unstructured":"Loos RJ, Katzmarzyk PT, Rao DC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rankinen T, Bouchard C, Study HF (2003) Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study. J Clin Endocrinol Metab 88(12):5935\u20135943. \n                    https:\/\/doi.org\/10.1210\/jc.2003-030553","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2781_CR104","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.2337\/db06-1389","volume":"56","author":"S Prudente","year":"2007","unstructured":"Prudente S, Flex E, Morini E, Turchi F, Capponi D, De Cosmo S, Tassi V, Guida V, Avogaro A, Folli F, Maiani F, Frittitta L, Dallapiccola B, Trischitta V (2007) A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. Diabetes 56(5):1468\u20131474. \n                    https:\/\/doi.org\/10.2337\/db06-1389","journal-title":"Diabetes"},{"key":"2781_CR105","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fendo.2015.00171","volume":"6","author":"A Rodriguez","year":"2015","unstructured":"Rodriguez A, Marinelli RA, Tesse A, Fruhbeck G, Calamita G (2015) Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders. Front Endocrinol 6:171. \n                    https:\/\/doi.org\/10.3389\/fendo.2015.00171","journal-title":"Front Endocrinol"},{"issue":"7","key":"2781_CR106","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1046\/j.1432-1033.2002.02821.x","volume":"269","author":"H Kondo","year":"2002","unstructured":"Kondo H, Shimomura I, Kishida K, Kuriyama H, Makino Y, Nishizawa H, Matsuda M, Maeda N, Nagaretani H, Kihara S, Kurachi Y, Nakamura T, Funahashi T, Matsuzawa Y (2002) Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. Eur J Biochem 269(7):1814\u20131826","journal-title":"Eur J Biochem"},{"issue":"51","key":"2781_CR107","doi-asserted-by":"publisher","first-page":"48572","DOI":"10.1074\/jbc.M108213200","volume":"276","author":"K Kishida","year":"2001","unstructured":"Kishida K, Shimomura I, Nishizawa H, Maeda N, Kuriyama H, Kondo H, Matsuda M, Nagaretani H, Ouchi N, Hotta K, Kihara S, Kadowaki T, Funahashi T, Matsuzawa Y (2001) Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma. J Biol Chem 276(51):48572\u201348579. \n                    https:\/\/doi.org\/10.1074\/jbc.M108213200","journal-title":"J Biol Chem"},{"issue":"5\u20136","key":"2781_CR108","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.mam.2012.02.004","volume":"33","author":"N Maeda","year":"2012","unstructured":"Maeda N (2012) Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome. Mol Asp Med 33(5\u20136):665\u2013675. \n                    https:\/\/doi.org\/10.1016\/j.mam.2012.02.004","journal-title":"Mol Asp Med"},{"issue":"4","key":"2781_CR109","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1055\/s-2003-39478","volume":"35","author":"M Fasshauer","year":"2003","unstructured":"Fasshauer M, Klein J, Lossner U, Klier M, Kralisch S, Paschke R (2003) Suppression of aquaporin adipose gene expression by isoproterenol, TNFalpha, and dexamethasone. Horm Metab Res 35(4):222\u2013227. \n                    https:\/\/doi.org\/10.1055\/s-2003-39478","journal-title":"Horm Metab Res"},{"issue":"5","key":"2781_CR110","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/ijo.2009.40","volume":"33","author":"A Rodriguez","year":"2009","unstructured":"Rodriguez A, Gomez-Ambrosi J, Catalan V, Gil MJ, Becerril S, Sainz N, Silva C, Salvador J, Colina I, Fruhbeck G (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Int J Obes (Lond) 33(5):541\u2013552. \n                    https:\/\/doi.org\/10.1038\/ijo.2009.40","journal-title":"Int J Obes (Lond)"},{"issue":"12","key":"2781_CR111","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.metabol.2016.09.004","volume":"65","author":"JS Hansen","year":"2016","unstructured":"Hansen JS, Krintel C, Hernebring M, Haataja TJ, de Mare S, Wasserstrom S, Kosinska-Eriksson U, Palmgren M, Holm C, Stenkula KG, Jones HA, Lindkvist-Petersson K (2016) Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Metabolism 65(12):1731\u20131742. \n                    https:\/\/doi.org\/10.1016\/j.metabol.2016.09.004","journal-title":"Metabolism"},{"issue":"6","key":"2781_CR112","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/boc.201100061","volume":"104","author":"G Calamita","year":"2012","unstructured":"Calamita G, Gena P, Ferri D, Rosito A, Rojek A, Nielsen S, Marinelli RA, Fruhbeck G, Svelto M (2012) Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol. Biol Cell 104(6):342\u2013351. \n                    https:\/\/doi.org\/10.1111\/boc.201100061","journal-title":"Biol Cell"},{"issue":"5\u20136","key":"2781_CR113","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.mam.2012.03.010","volume":"33","author":"P Portincasa","year":"2012","unstructured":"Portincasa P, Calamita G (2012) Water channel proteins in bile formation and flow in health and disease: when immiscible becomes miscible. Mol Asp Med 33(5\u20136):651\u2013664. \n                    https:\/\/doi.org\/10.1016\/j.mam.2012.03.010","journal-title":"Mol Asp Med"},{"issue":"4","key":"2781_CR114","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00418-015-1341-3","volume":"144","author":"F Gregoire","year":"2015","unstructured":"Gregoire F, Lucidi V, Zerrad-Saadi A, Virreira M, Bolaky N, Delforge V, Lemmers A, Donckier V, Deviere J, Demetter P, Perret J, Delporte C (2015) Analysis of aquaporin expression in liver with a focus on hepatocytes. Histochem Cell Biol 144(4):347\u2013363. \n                    https:\/\/doi.org\/10.1007\/s00418-015-1341-3","journal-title":"Histochem Cell Biol"},{"issue":"10","key":"2781_CR115","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.2337\/diabetes.51.10.2915","volume":"51","author":"H Kuriyama","year":"2002","unstructured":"Kuriyama H, Shimomura I, Kishida K, Kondo H, Furuyama N, Nishizawa H, Maeda N, Matsuda M, Nagaretani H, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y (2002) Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes 51(10):2915\u20132921","journal-title":"Diabetes"},{"key":"2781_CR116","doi-asserted-by":"publisher","first-page":"12067","DOI":"10.1038\/srep12067","volume":"5","author":"A Rodriguez","year":"2015","unstructured":"Rodriguez A, Moreno NR, Balaguer I, Mendez-Gimenez L, Becerril S, Catalan V, Gomez-Ambrosi J, Portincasa P, Calamita G, Soveral G, Malagon MM, Fruhbeck G (2015) Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob\/ob mice. Sci Rep 5:12067. \n                    https:\/\/doi.org\/10.1038\/srep12067","journal-title":"Sci Rep"},{"issue":"3","key":"2781_CR117","doi-asserted-by":"publisher","first-page":"G365","DOI":"10.1152\/ajpgi.00437.2011","volume":"302","author":"J Lebeck","year":"2012","unstructured":"Lebeck J, Gena P, O\u2019Neill H, Skowronski MT, Lund S, Calamita G, Praetorius J (2012) Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation. Am J Physiol Gastrointest Liver Physiol 302(3):G365\u2013G374. \n                    https:\/\/doi.org\/10.1152\/ajpgi.00437.2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"10","key":"2781_CR118","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3760\/cma.j.issn.1007-3418.2013.10.008","volume":"21","author":"LY Gu","year":"2013","unstructured":"Gu LY, Qiu LW, Chen XF, Lv L, Mei ZC (2013) Expression of aquaporin 3 and aquaporin 9 is regulated by oleic acid through the PI3K\/Akt and p38 MAPK signaling pathways. Zhonghua Gan Zang Bing Za Zhi 21(10):753\u2013758. \n                    https:\/\/doi.org\/10.3760\/cma.j.issn.1007-3418.2013.10.008","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"9","key":"2781_CR119","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/ijo.2013.234","volume":"38","author":"A Rodriguez","year":"2014","unstructured":"Rodriguez A, Gena P, Mendez-Gimenez L, Rosito A, Valenti V, Rotellar F, Sola I, Moncada R, Silva C, Svelto M, Salvador J, Calamita G, Fruhbeck G (2014) Reduced hepatic aquaporin-9 and glycerol permeability are related to insulin resistance in non-alcoholic fatty liver disease. Int J Obes (Lond) 38(9):1213\u20131220. \n                    https:\/\/doi.org\/10.1038\/ijo.2013.234","journal-title":"Int J Obes (Lond)"},{"issue":"5","key":"2781_CR120","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3892\/ijmm.2013.1502","volume":"32","author":"C Wang","year":"2013","unstructured":"Wang C, Lv ZL, Kang YJ, Xiang TX, Wang PL, Jiang Z (2013) Aquaporin-9 downregulation prevents steatosis in oleic acid-induced non-alcoholic fatty liver disease cell models. Int J Mol Med 32(5):1159\u20131165. \n                    https:\/\/doi.org\/10.3892\/ijmm.2013.1502","journal-title":"Int J Mol Med"},{"issue":"12","key":"2781_CR121","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1016\/j.metabol.2009.06.004","volume":"58","author":"M Miranda","year":"2009","unstructured":"Miranda M, Ceperuelo-Mallafre V, Lecube A, Hernandez C, Chacon MR, Fort JM, Gallart L, Baena-Fustegueras JA, Simo R, Vendrell J (2009) Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities. Metabolism 58(12):1762\u20131768. \n                    https:\/\/doi.org\/10.1016\/j.metabol.2009.06.004","journal-title":"Metabolism"},{"issue":"1\u20132","key":"2781_CR122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10735-004-2633-4","volume":"36","author":"A Mobasheri","year":"2005","unstructured":"Mobasheri A, Wray S, Marples D (2005) Distribution of AQP2 and AQP3 water channels in human tissue microarrays. J Mol Histol 36(1\u20132):1\u201314. \n                    https:\/\/doi.org\/10.1007\/s10735-004-2633-4","journal-title":"J Mol Histol"},{"issue":"4","key":"2781_CR123","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1210\/jc.2004-1830","volume":"90","author":"K Sjoholm","year":"2005","unstructured":"Sjoholm K, Palming J, Olofsson LE, Gummesson A, Svensson PA, Lystig TC, Jennische E, Brandberg J, Torgerson JS, Carlsson B, Carlsson LM (2005) A microarray search for genes predominantly expressed in human omental adipocytes: adipose tissue as a major production site of serum amyloid A. J Clin Endocrinol Metab 90(4):2233\u20132239. \n                    https:\/\/doi.org\/10.1210\/jc.2004-1830","journal-title":"J Clin Endocrinol Metab"},{"issue":"14","key":"2781_CR124","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1161\/01.CIR.0000012466.50373.E8","volume":"105","author":"H Taegtmeyer","year":"2002","unstructured":"Taegtmeyer H, McNulty P, Young ME (2002) Adaptation and maladaptation of the heart in diabetes: part I: general concepts. Circulation 105(14):1727\u20131733","journal-title":"Circulation"},{"issue":"2","key":"2781_CR125","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0008-6363(96)00245-3","volume":"33","author":"WC Stanley","year":"1997","unstructured":"Stanley WC, Lopaschuk GD, Hall JL, McCormack JG (1997) Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res 33(2):243\u2013257","journal-title":"Cardiovasc Res"},{"issue":"6","key":"2781_CR126","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1089\/dna.1996.15.475","volume":"15","author":"F Umenishi","year":"1996","unstructured":"Umenishi F, Verkman AS, Gropper MA (1996) Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay. DNA Cell Biol 15(6):475\u2013480","journal-title":"DNA Cell Biol"},{"issue":"6\u20137","key":"2781_CR127","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1023\/A:1023382609541","volume":"34","author":"Y Wakayama","year":"2002","unstructured":"Wakayama Y, Jimi T, Inoue M, Kojima H, Shibuya S, Murahashi M, Hara H, Oniki H (2002) Expression of aquaporin 3 and its localization in normal skeletal myofibres. Histochem J 34(6\u20137):331\u2013337","journal-title":"Histochem J"},{"issue":"2","key":"2781_CR128","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/jmicro\/dfl017","volume":"55","author":"S Shibuya","year":"2006","unstructured":"Shibuya S, Wakayama Y, Inoue M, Kojima H, Oniki H (2006) The relationship between intramembranous particles and aquaporin molecules in the plasma membranes of normal rat skeletal muscles: a fracture-label study. J Electron Microsc (Tokyo) 55(2):63\u201368. \n                    https:\/\/doi.org\/10.1093\/jmicro\/dfl017","journal-title":"J Electron Microsc (Tokyo)"},{"issue":"6","key":"2781_CR129","doi-asserted-by":"publisher","first-page":"C1108","DOI":"10.1152\/ajpcell.2000.278.6.C1108","volume":"278","author":"B Yang","year":"2000","unstructured":"Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS (2000) Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol 278(6):C1108\u2013C1115","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"2781_CR130","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00441-004-0857-y","volume":"316","author":"Y Wakayama","year":"2004","unstructured":"Wakayama Y, Inoue M, Kojima H, Jimi T, Shibuya S, Hara H, Oniki H (2004) Expression and localization of aquaporin 7 in normal skeletal myofiber. Cell Tissue Res 316(1):123\u2013129. \n                    https:\/\/doi.org\/10.1007\/s00441-004-0857-y","journal-title":"Cell Tissue Res"},{"issue":"3","key":"2781_CR131","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/aps.2010.17","volume":"31","author":"X Chen","year":"2010","unstructured":"Chen X, Yu QQ, Zhu YH, Bi Y, Sun WP, Liang H, Cai MY, He XY, Weng JP (2010) Insulin therapy stimulates lipid synthesis and improves endocrine functions of adipocytes in dietary obese C57BL\/6 mice. Acta Pharmacol Sin 31(3):341\u2013346. \n                    https:\/\/doi.org\/10.1038\/aps.2010.17","journal-title":"Acta Pharmacol Sin"},{"issue":"Pt 1","key":"2781_CR132","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1469-7793.1997.00191.x","volume":"504","author":"HE Miley","year":"1997","unstructured":"Miley HE, Sheader EA, Brown PD, Best L (1997) Glucose-induced swelling in rat pancreatic beta-cells. J Physiol 504(Pt 1):191\u2013198","journal-title":"J Physiol"},{"key":"2781_CR133","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-90-481-3271-3_7","volume":"654","author":"G Drews","year":"2010","unstructured":"Drews G, Krippeit-Drews P, Dufer M (2010) Electrophysiology of islet cells. Adv Exp Med Biol 654:115\u2013163. \n                    https:\/\/doi.org\/10.1007\/978-90-481-3271-3_7","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"2781_CR134","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.bbagen.2013.08.007","volume":"1840","author":"C Delporte","year":"2014","unstructured":"Delporte C (2014) Aquaporins in salivary glands and pancreas. Biochem Biophys Acta 1840(5):1524\u20131532. \n                    https:\/\/doi.org\/10.1016\/j.bbagen.2013.08.007","journal-title":"Biochem Biophys Acta"},{"issue":"2","key":"2781_CR135","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/jcp.21872","volume":"221","author":"C Delporte","year":"2009","unstructured":"Delporte C, Virreira M, Crutzen R, Louchami K, Sener A, Malaisse WJ, Beauwens R (2009) Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11. J Cell Physiol 221(2):424\u2013429. \n                    https:\/\/doi.org\/10.1002\/jcp.21872","journal-title":"J Cell Physiol"},{"issue":"9","key":"2781_CR136","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/ijo.2017.135","volume":"41","author":"L Mendez-Gimenez","year":"2017","unstructured":"Mendez-Gimenez L, Becerril S, Camoes SP, da Silva IV, Rodrigues C, Moncada R, Valenti V, Catalan V, Gomez-Ambrosi J, Miranda JP, Soveral G, Fruhbeck G, Rodriguez A (2017) Role of aquaporin-7 in ghrelin- and GLP-1-induced improvement of pancreatic beta-cell function after sleeve gastrectomy in obese rats. Int J Obes (Lond) 41(9):1394\u20131402. \n                    https:\/\/doi.org\/10.1038\/ijo.2017.135","journal-title":"Int J Obes (Lond)"},{"key":"2781_CR137","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010130","author":"IV Silva da","year":"2018","unstructured":"da Silva IV, Barroso M, Moura T, Castro R, Soveral G (2018) Endothelial aquaporins and hypomethylation: potential implications for atherosclerosis and cardiovascular disease. Int J Mol Sci. \n                    https:\/\/doi.org\/10.3390\/ijms19010130","journal-title":"Int J Mol Sci"},{"key":"2781_CR138","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","volume":"29","author":"MF Gregor","year":"2011","unstructured":"Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415\u2013445. \n                    https:\/\/doi.org\/10.1146\/annurev-immunol-031210-101322","journal-title":"Annu Rev Immunol"},{"issue":"4 Pt 1","key":"2781_CR139","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.diabet.2008.04.001","volume":"34","author":"M Lafontan","year":"2008","unstructured":"Lafontan M, Girard J (2008) Impact of visceral adipose tissue on liver metabolism. Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue. Diabetes Metab 34(4 Pt 1):317\u2013327. \n                    https:\/\/doi.org\/10.1016\/j.diabet.2008.04.001","journal-title":"Diabetes Metab"},{"issue":"2","key":"2781_CR140","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ddmec.2004.09.010","volume":"1","author":"NN Mehta","year":"2004","unstructured":"Mehta NN, Reilly MP (2004) Mechanisms of the metabolic syndrome. Drug Discov Today Dis Mech 1(2):187\u2013194. \n                    https:\/\/doi.org\/10.1016\/j.ddmec.2004.09.010","journal-title":"Drug Discov Today Dis Mech"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-018-2781-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-018-2781-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-018-2781-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:04:47Z","timestamp":1550606687000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-018-2781-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":140,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["2781"],"URL":"https:\/\/doi.org\/10.1007\/s00018-018-2781-4","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]},"assertion":[{"value":"2 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}