{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:34:07Z","timestamp":1776731647586,"version":"3.51.2"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"funda\u00e7\u00e3o para a ci\u00eancia e a tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-028214"],"award-info":[{"award-number":["POCI-01-0145-FEDER-028214"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"funda\u00e7\u00e3o para a ci\u00eancia e a tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-029369"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029369"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"funda\u00e7\u00e3o para a ci\u00eancia e a tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/101028\/2014"],"award-info":[{"award-number":["SFRH\/BPD\/101028\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"funda\u00e7\u00e3o para a ci\u00eancia e a tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/148653\/2019"],"award-info":[{"award-number":["SFRH\/BD\/148653\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00018-022-04211-7","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T12:08:42Z","timestamp":1648469322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-0865","authenticated-orcid":false,"given":"Ana Catarina","family":"Pereira","sequence":"first","affiliation":[]},{"given":"Jessica","family":"De Pascale","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Resende","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Bruno Miguel","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Myl\u00e8ne A.","family":"Carrascal","sequence":"additional","affiliation":[]},{"given":"M\u00f3nica","family":"Zuzarte","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Madeira","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Morais","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Macedo","sequence":"additional","affiliation":[]},{"given":"An\u00e1lia","family":"do Carmo","sequence":"additional","affiliation":[]},{"given":"Paula I.","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"Maria Teresa","family":"Cruz","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia F.","family":"Pereira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"4211_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2017.01.003","volume":"62","author":"R Filadi","year":"2017","unstructured":"Filadi R, Theurey P, Pizzo P (2017) The endoplasmic reticulum-mitochondria coupling in health and disease: molecules, functions and significance. Cell Calcium 62:1\u201315. https:\/\/doi.org\/10.1016\/j.ceca.2017.01.003","journal-title":"Cell Calcium"},{"key":"4211_CR2","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1017\/S1461145714000443","volume":"17","author":"B Pfaffenseller","year":"2014","unstructured":"Pfaffenseller B, Wollenhaupt-Aguiar B, Fries GR et al (2014) Impaired endoplasmic reticulum stress response in bipolar disorder: cellular evidence of illness progression. Int J Neuropsychopharmacol 17:1453\u20131463. https:\/\/doi.org\/10.1017\/S1461145714000443","journal-title":"Int J Neuropsychopharmacol"},{"key":"4211_CR3","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519\u2013529. https:\/\/doi.org\/10.1038\/nrm2199","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4211_CR4","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/J.BBAMCR.2010.11.023","volume":"1813","author":"J-P Decuypere","year":"2011","unstructured":"Decuypere J-P, Monaco G, Bultynck G et al (2011) The IP3 receptor\u2013mitochondria connection in apoptosis and autophagy. Biochim Biophys Acta Mol Cell Res 1813:1003\u20131013. https:\/\/doi.org\/10.1016\/J.BBAMCR.2010.11.023","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"4211_CR5","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","volume":"70","author":"S Deegan","year":"2013","unstructured":"Deegan S, Saveljeva S, Gorman AM, Samali A (2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress. Cell Mol Life Sci 70:2425\u20132441. https:\/\/doi.org\/10.1007\/s00018-012-1173-4","journal-title":"Cell Mol Life Sci"},{"key":"4211_CR6","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1242\/jcs.068833","volume":"123","author":"KY Tsang","year":"2010","unstructured":"Tsang KY, Chan D, Bateman JF, Cheah KSE (2010) In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences. J Cell Sci 123:2145\u20132154. https:\/\/doi.org\/10.1242\/jcs.068833","journal-title":"J Cell Sci"},{"key":"4211_CR7","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nrd2755","volume":"7","author":"I Kim","year":"2008","unstructured":"Kim I, Xu W, Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7:1013\u20131030. https:\/\/doi.org\/10.1038\/nrd2755","journal-title":"Nat Rev Drug Discov"},{"key":"4211_CR8","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/ncb3184","volume":"17","author":"C Hetz","year":"2015","unstructured":"Hetz C, Chevet E, Oakes SA (2015) Proteostasis control by the unfolded protein response. Nat Cell Biol 17:829\u2013838. https:\/\/doi.org\/10.1038\/ncb3184","journal-title":"Nat Cell Biol"},{"key":"4211_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ceb.2018.06.004","volume":"53","author":"A Spang","year":"2018","unstructured":"Spang A (2018) The endoplasmic reticulum-the caring mother of the cell. Curr Opin Cell Biol 53:92\u201396. https:\/\/doi.org\/10.1016\/j.ceb.2018.06.004","journal-title":"Curr Opin Cell Biol"},{"key":"4211_CR10","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3390\/cells8121617","volume":"8","author":"J Li","year":"2019","unstructured":"Li J, Zhang D, Brundel BJJM, Wiersma M (2019) Imbalance of ER and mitochondria interactions: prelude to cardiac ageing and disease? Cells 8:1617","journal-title":"Cells"},{"key":"4211_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1083\/jcb.201401126","volume":"205","author":"WA Prinz","year":"2014","unstructured":"Prinz WA (2014) Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics. J Cell Biol 205:759\u2013769. https:\/\/doi.org\/10.1083\/jcb.201401126","journal-title":"J Cell Biol"},{"key":"4211_CR12","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1038\/emboj.2012.202","volume":"31","author":"E Area-Gomez","year":"2012","unstructured":"Area-Gomez E, Del Carmen Lara CastilloTambini MMD et al (2012) Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J 31:4106\u20134123. https:\/\/doi.org\/10.1038\/emboj.2012.202","journal-title":"EMBO J"},{"key":"4211_CR13","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41419-017-0027-2","volume":"9","author":"S Missiroli","year":"2018","unstructured":"Missiroli S, Patergnani S, Caroccia N et al (2018) Mitochondria-associated membranes (MAMs) and inflammation. Cell Death Dis 9:329. https:\/\/doi.org\/10.1038\/s41419-017-0027-2","journal-title":"Cell Death Dis"},{"key":"4211_CR14","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/nrm3440","volume":"13","author":"AA Rowland","year":"2012","unstructured":"Rowland AA, Voeltz GK (2012) Endoplasmic reticulum\u2013mitochondria contacts: function of the junction. Nat Rev Mol Cell Biol 13:607\u2013625. https:\/\/doi.org\/10.1038\/nrm3440","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4211_CR15","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/j.bbamcr.2014.03.009","volume":"1843","author":"AR van Vliet","year":"2014","unstructured":"van Vliet AR, Verfaillie T, Agostinis P (2014) New functions of mitochondria associated membranes in cellular signaling. Biochim Biophys Acta Mol Cell Res 1843:2253\u20132262. https:\/\/doi.org\/10.1016\/j.bbamcr.2014.03.009","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"4211_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.phrs.2018.01.003","volume":"128","author":"R Filadi","year":"2018","unstructured":"Filadi R, Greotti E, Pizzo P (2018) Highlighting the endoplasmic reticulum-mitochondria connection: focus on mitofusin 2. Pharmacol Res 128:42\u201351","journal-title":"Pharmacol Res"},{"key":"4211_CR17","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo H, Callaway JB, Ting JP-Y (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21:677\u2013687. https:\/\/doi.org\/10.1038\/nm.3893","journal-title":"Nat Med"},{"key":"4211_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nrn3638","volume":"15","author":"JG Walsh","year":"2014","unstructured":"Walsh JG, Muruve DA, Power C (2014) Inflammasomes in the CNS. Nat Rev Neurosci 15:84\u201397. https:\/\/doi.org\/10.1038\/nrn3638","journal-title":"Nat Rev Neurosci"},{"key":"4211_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.it.2012.03.001","volume":"33","author":"R Hanamsagar","year":"2012","unstructured":"Hanamsagar R, Hanke ML, Kielian T (2012) Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 33:333\u2013342. https:\/\/doi.org\/10.1016\/j.it.2012.03.001","journal-title":"Trends Immunol"},{"key":"4211_CR20","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","volume":"41","author":"Y He","year":"2016","unstructured":"He Y, Hara H, N\u00fa\u00f1ez G (2016) Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci 41:1012\u20131021. https:\/\/doi.org\/10.1016\/j.tibs.2016.09.002","journal-title":"Trends Biochem Sci"},{"key":"4211_CR21","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","volume":"44","author":"MM Gaidt","year":"2016","unstructured":"Gaidt MM, Ebert TS, Chauhan D et al (2016) Human monocytes engage an alternative inflammasome pathway. Immunity 44:833\u2013846. https:\/\/doi.org\/10.1016\/j.immuni.2016.01.012","journal-title":"Immunity"},{"key":"4211_CR22","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"FG Bauernfeind","year":"2009","unstructured":"Bauernfeind FG, Horvath G, Stutz A et al (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183:787\u2013791. https:\/\/doi.org\/10.4049\/jimmunol.0901363","journal-title":"J Immunol"},{"key":"4211_CR23","doi-asserted-by":"publisher","first-page":"792","DOI":"10.4049\/jimmunol.0900173","volume":"183","author":"L Franchi","year":"2009","unstructured":"Franchi L, Eigenbrod T, Nunez G (2009) Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183:792\u2013796. https:\/\/doi.org\/10.4049\/jimmunol.0900173","journal-title":"J Immunol"},{"key":"4211_CR24","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.1242\/jcs.207365","volume":"130","author":"A Malik","year":"2017","unstructured":"Malik A, Kanneganti T-D (2017) Inflammasome activation and assembly at a glance. J Cell Sci 130:3955\u20133963. https:\/\/doi.org\/10.1242\/jcs.207365","journal-title":"J Cell Sci"},{"key":"4211_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328","author":"N Kelley","year":"2019","unstructured":"Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20133328","journal-title":"Int J Mol Sci"},{"key":"4211_CR26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469:221\u2013225. https:\/\/doi.org\/10.1038\/nature09663","journal-title":"Nature"},{"key":"4211_CR27","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","volume":"153","author":"N Subramanian","year":"2013","unstructured":"Subramanian N, Natarajan K, Clatworthy MR et al (2013) The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 153:348\u2013361. https:\/\/doi.org\/10.1016\/j.cell.2013.02.054","journal-title":"Cell"},{"key":"4211_CR28","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.3390\/cells9051219","volume":"9","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, Tong Z, Jiang S et al (2020) The roles of endoplasmic reticulum in NLRP3 inflammasome activation. Cells 9:1219","journal-title":"Cells"},{"key":"4211_CR29","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201709057","author":"M de la Roche","year":"2018","unstructured":"de la Roche M, Hamilton C, Mortensen R et al (2018) Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. https:\/\/doi.org\/10.1083\/JCB.201709057","journal-title":"J Cell Biol"},{"key":"4211_CR30","doi-asserted-by":"crossref","unstructured":"Misawa T, Takahama M, Saitoh T (2017) Mitochondria\u2013endoplasmic reticulum contact sites mediate innate immune responses. Adv Exp Med Biol 187\u2013197","DOI":"10.1007\/978-981-10-4567-7_14"},{"key":"4211_CR31","doi-asserted-by":"publisher","first-page":"165752","DOI":"10.1016\/j.bbadis.2020.165752","volume":"1866","author":"R Resende","year":"2020","unstructured":"Resende R, Fernandes T, Pereira AC et al (2020) Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: do mitochondria-associated membranes (MAMs) play a role? Biochim Biophys acta Mol basis Dis 1866:165752. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165752","journal-title":"Biochim Biophys acta Mol basis Dis"},{"key":"4211_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100966","author":"CF Pereira","year":"2019","unstructured":"Pereira CF, Santos AE, Moreira PI et al (2019) Is Alzheimer\u2019s disease an inflammasomopathy? Ageing Res Rev. https:\/\/doi.org\/10.1016\/j.arr.2019.100966","journal-title":"Ageing Res Rev"},{"key":"4211_CR33","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/S0140-6736(20)31544-0","volume":"396","author":"RS McIntyre","year":"2020","unstructured":"McIntyre RS, Berk M, Brietzke E et al (2020) Bipolar disorders. Lancet 396:1841\u20131856","journal-title":"Lancet"},{"key":"4211_CR34","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/wps.20441","volume":"16","author":"M Berk","year":"2017","unstructured":"Berk M, Post R, Ratheesh A et al (2017) Staging in bipolar disorder: from theoretical framework to clinical utility. World Psychiatry 16:236\u2013244. https:\/\/doi.org\/10.1002\/wps.20441","journal-title":"World Psychiatry"},{"key":"4211_CR35","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and of statistical manual mental disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association (2013) Diagnostic and of statistical manual mental disorders. American Psychiatric Association, Washington, D.C."},{"key":"4211_CR36","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.psychres.2018.12.176","volume":"272","author":"MJ Martins","year":"2019","unstructured":"Martins MJ, Palmeira L, Xavier A et al (2019) The clinical interview for psychotic disorders (CIPD): preliminary results on interrater agreement, reliability and qualitative feedback. Psychiatry Res 272:723\u2013729. https:\/\/doi.org\/10.1016\/j.psychres.2018.12.176","journal-title":"Psychiatry Res"},{"key":"4211_CR37","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/cells11030433","volume":"11","author":"AC Pereira","year":"2022","unstructured":"Pereira AC, Madeira N, Morais S et al (2022) Mitochondria fusion upon SERCA inhibition prevents activation of the NLRP3 inflammasome in human monocytes. Cells 11:433. https:\/\/doi.org\/10.3390\/cells11030433","journal-title":"Cells"},{"key":"4211_CR38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jphs.2014.12.005","volume":"127","author":"L Nguyen","year":"2015","unstructured":"Nguyen L, Lucke-Wold BP, Mookerjee SA et al (2015) Role of sigma-1 receptors in neurodegenerative diseases. J Pharmacol Sci 127:17\u201329. https:\/\/doi.org\/10.1016\/j.jphs.2014.12.005","journal-title":"J Pharmacol Sci"},{"key":"4211_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ceb.2018.04.014","volume":"53","author":"T Simmen","year":"2018","unstructured":"Simmen T, Herrera-Cruz MS (2018) Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling. Curr Opin Cell Biol 53:61\u201369. https:\/\/doi.org\/10.1016\/j.ceb.2018.04.014","journal-title":"Curr Opin Cell Biol"},{"key":"4211_CR40","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1083\/jcb.200904060","volume":"186","author":"G Li","year":"2009","unstructured":"Li G, Mongillo M, Chin K-T et al (2009) Role of ERO1-\u03b1\u2013mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress\u2013induced apoptosis. J Cell Biol 186:783\u2013792. https:\/\/doi.org\/10.1083\/jcb.200904060","journal-title":"J Cell Biol"},{"key":"4211_CR41","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3389\/fphar.2018.00711","volume":"9","author":"A Tesei","year":"2018","unstructured":"Tesei A, Cortesi M, Zamagni A et al (2018) Sigma receptors as endoplasmic reticulum stress \u201cgatekeepers\u201d and their modulators as emerging new weapons in the fight against cancer. Front Pharmacol 9:711. https:\/\/doi.org\/10.3389\/fphar.2018.00711","journal-title":"Front Pharmacol"},{"key":"4211_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-017-0380-6","volume":"24","author":"TY Weng","year":"2017","unstructured":"Weng TY, Tsai SYA, Su TP (2017) Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases. J Biomed Sci 24:1\u201314","journal-title":"J Biomed Sci"},{"key":"4211_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz472","author":"D Lehmann","year":"2019","unstructured":"Lehmann D, Tuppen HAL, Campbell GE et al (2019) Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkz472","journal-title":"Nucleic Acids Res"},{"key":"4211_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00796","author":"S Contino","year":"2017","unstructured":"Contino S, Porporato PE, Bird M et al (2017) Presenilin 2-dependent maintenance of mitochondrial oxidative capacity and morphology. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2017.00796","journal-title":"Front Physiol"},{"key":"4211_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.03.009","author":"S Li","year":"2016","unstructured":"Li S, Bouzar C, Cottet-Rousselle C et al (2016) Resveratrol inhibits lipogenesis of 3T3-L1 and SGBS cells by inhibition of insulin signaling and mitochondrial mass increase. Biochim Biophys Acta Bioenerg. https:\/\/doi.org\/10.1016\/j.bbabio.2016.03.009","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"4211_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.08.001","author":"N Kozhukhar","year":"2019","unstructured":"Kozhukhar N, Alexeyev MF (2019) Limited predictive value of TFAM in mitochondrial biogenesis. Mitochondrion. https:\/\/doi.org\/10.1016\/j.mito.2019.08.001","journal-title":"Mitochondrion"},{"key":"4211_CR47","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbabio.2017.01.004","volume":"1858","author":"S Srinivasan","year":"2017","unstructured":"Srinivasan S, Guha M, Kashina A, Avadhani NG (2017) Mitochondrial dysfunction and mitochondrial dynamics\u2014the cancer connection. Biochim Biophys Acta Bioenerg 1858:602\u2013614. https:\/\/doi.org\/10.1016\/j.bbabio.2017.01.004","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"4211_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2012798","volume":"2017","author":"OC Moreira","year":"2017","unstructured":"Moreira OC, Est\u00e9banez B, Mart\u00ednez-Florez S et al (2017) Mitochondrial function and mitophagy in the elderly: effects of exercise. Oxid Med Cell Longev 2017:1\u201313. https:\/\/doi.org\/10.1155\/2017\/2012798","journal-title":"Oxid Med Cell Longev"},{"key":"4211_CR49","doi-asserted-by":"publisher","first-page":"11249","DOI":"10.1073\/pnas.1606786113","volume":"113","author":"D Naon","year":"2016","unstructured":"Naon D, Zaninello M, Giacomello M et al (2016) Critical reappraisal confirms that mitofusin 2 is an endoplasmic reticulum\u2013mitochondria tether. Proc Natl Acad Sci 113:11249\u201311254. https:\/\/doi.org\/10.1073\/pnas.1606786113","journal-title":"Proc Natl Acad Sci"},{"key":"4211_CR50","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.mam.2018.03.002","volume":"63","author":"CD Ochoa","year":"2018","unstructured":"Ochoa CD, Wu RF, Terada LS (2018) ROS signaling and ER stress in cardiovascular disease. Mol Aspects Med 63:18\u201329. https:\/\/doi.org\/10.1016\/j.mam.2018.03.002","journal-title":"Mol Aspects Med"},{"key":"4211_CR51","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1002\/jcp.24360","volume":"228","author":"K Vannuvel","year":"2013","unstructured":"Vannuvel K, Renard P, Raes M, Arnould T (2013) Functional and morphological impact of ER stress on mitochondria. J Cell Physiol 228:1802\u20131818. https:\/\/doi.org\/10.1002\/jcp.24360","journal-title":"J Cell Physiol"},{"key":"4211_CR52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705002200","author":"WC Chang","year":"2008","unstructured":"Chang WC, Di Capite J, Singaravelu K et al (2008) Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.M705002200","journal-title":"J Biol Chem"},{"key":"4211_CR53","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3389\/fimmu.2016.00597","volume":"7","author":"Q-B Zha","year":"2016","unstructured":"Zha Q-B, Wei H-X, Li C-G et al (2016) ATP-induced inflammasome activation and pyroptosis is regulated by AMP-activated protein kinase in macrophages. Front Immunol 7:597. https:\/\/doi.org\/10.3389\/fimmu.2016.00597","journal-title":"Front Immunol"},{"key":"4211_CR54","doi-asserted-by":"publisher","first-page":"18","DOI":"10.4068\/cmj.2016.52.1.18","volume":"52","author":"A Muneer","year":"2016","unstructured":"Muneer A (2016) The neurobiology of bipolar disorder: an integrated approach. Chonnam Med J 52:18\u201337. https:\/\/doi.org\/10.4068\/cmj.2016.52.1.18","journal-title":"Chonnam Med J"},{"key":"4211_CR55","doi-asserted-by":"publisher","unstructured":"Pereira AC, Resende R, Morais S, et al (2017) The ups and downs of cellular stress: the \u201cMAM hypothesis\u201d for bipolar disorder pathophysiology. Int J Clin Neurosci Ment Heal 4:S04. https:\/\/doi.org\/10.21035\/ijcnmh.2017.4(Suppl.3).S04","DOI":"10.21035\/ijcnmh.2017.4(Suppl.3).S04"},{"key":"4211_CR56","doi-asserted-by":"publisher","first-page":"105325","DOI":"10.1016\/j.phrs.2020.105325","volume":"163","author":"AC Pereira","year":"2021","unstructured":"Pereira AC, Oliveira J, Silva S et al (2021) Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets. Pharmacol Res 163:105325","journal-title":"Pharmacol Res"},{"key":"4211_CR57","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1002\/jcp.26479","volume":"233","author":"P Rajendran","year":"2018","unstructured":"Rajendran P, Chen Y-F, Chen Y-F et al (2018) The multifaceted link between inflammation and human diseases. J Cell Physiol 233:6458\u20136471. https:\/\/doi.org\/10.1002\/jcp.26479","journal-title":"J Cell Physiol"},{"key":"4211_CR58","doi-asserted-by":"publisher","unstructured":"So J-S (2018) Roles of endoplasmic reticulum stress in immune responses. Mol Cells 41:705\u2013716. https:\/\/doi.org\/10.14348\/molcells.2018.0241","DOI":"10.14348\/molcells.2018.0241"},{"key":"4211_CR59","doi-asserted-by":"publisher","first-page":"e261","DOI":"10.1038\/cddis.2011.132","volume":"3","author":"P Menu","year":"2012","unstructured":"Menu P, Mayor A, Zhou R et al (2012) ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis 3:e261. https:\/\/doi.org\/10.1038\/cddis.2011.132","journal-title":"Cell Death Dis"},{"key":"4211_CR60","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/B978-0-12-407704-1.00005-1","volume":"301","author":"R Bravo","year":"2013","unstructured":"Bravo R, Parra V, Gatica D et al (2013) Endoplasmic reticulum and the unfolded protein response. Int Rev Cell Mol Biol 301:215\u2013290","journal-title":"Int Rev Cell Mol Biol"},{"key":"4211_CR61","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jep.2017.12.002","volume":"214","author":"B Zhang","year":"2018","unstructured":"Zhang B, Gao C, Li Y, Wang M (2018) D-chiro-inositol enriched Fagopyrum tataricum (L.) gaench extract alleviates mitochondrial malfunction and inhibits ER stress\/JNK associated inflammation in the endothelium. J Ethnopharmacol 214:83\u201389. https:\/\/doi.org\/10.1016\/j.jep.2017.12.002","journal-title":"J Ethnopharmacol"},{"key":"4211_CR62","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11010-012-1248-4","volume":"365","author":"X Li","year":"2012","unstructured":"Li X, Zhu H, Huang H et al (2012) Study on the effect of IRE1\u03b1 on cell growth and apoptosis via modulation PLK1 in ER stress response. Mol Cell Biochem 365:99\u2013108. https:\/\/doi.org\/10.1007\/s11010-012-1248-4","journal-title":"Mol Cell Biochem"},{"key":"4211_CR63","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/J.TIBS.2018.06.005","volume":"43","author":"J Hwang","year":"2018","unstructured":"Hwang J, Qi L (2018) Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways. Trends Biochem Sci 43:593\u2013605. https:\/\/doi.org\/10.1016\/J.TIBS.2018.06.005","journal-title":"Trends Biochem Sci"},{"key":"4211_CR64","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/toxsci\/kfx096","volume":"158","author":"X Chen","year":"2017","unstructured":"Chen X, Zhong J, Dong D et al (2017) Endoplasmic reticulum stress-induced CHOP inhibits PGC-1\u03b1 and causes mitochondrial dysfunction in diabetic embryopathy. Toxicol Sci 158:275\u2013285. https:\/\/doi.org\/10.1093\/toxsci\/kfx096","journal-title":"Toxicol Sci"},{"key":"4211_CR65","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3967\/bes2018.076","volume":"31","author":"YK Tao","year":"2018","unstructured":"Tao YK, Shi J, Yu PL, Zhang GQ (2018) The role of endoplasmic reticulum stress-related apoptosis in vascular endothelium pathogenesis. Biomed Environ Sci 31:555\u2013559. https:\/\/doi.org\/10.3967\/bes2018.076","journal-title":"Biomed Environ Sci"},{"key":"4211_CR66","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s12192-010-0174-1","volume":"15","author":"SY Gilady","year":"2010","unstructured":"Gilady SY, Bui M, Lynes EM et al (2010) Ero1\u03b1 requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM). Cell Stress Chaperones 15:619\u2013629. https:\/\/doi.org\/10.1007\/s12192-010-0174-1","journal-title":"Cell Stress Chaperones"},{"key":"4211_CR67","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1089\/ars.2011.4004","volume":"16","author":"T Anelli","year":"2012","unstructured":"Anelli T, Bergamelli L, Margittai E et al (2012) Ero1\u03b1 regulates Ca 2+ fluxes at the endoplasmic reticulum-mitochondria interface (MAM). Antioxid Redox Signal 16:1077\u20131087. https:\/\/doi.org\/10.1089\/ars.2011.4004","journal-title":"Antioxid Redox Signal"},{"key":"4211_CR68","doi-asserted-by":"publisher","first-page":"e968","DOI":"10.1038\/cddis.2013.502","volume":"4","author":"M Seervi","year":"2013","unstructured":"Seervi M, Sobhan PK, Joseph J et al (2013) ERO1\u03b1-dependent endoplasmic reticulum\u2013mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis 4:e968\u2013e968. https:\/\/doi.org\/10.1038\/cddis.2013.502","journal-title":"Cell Death Dis"},{"key":"4211_CR69","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","volume":"131","author":"T Hayashi","year":"2007","unstructured":"Hayashi T, Su T-P (2007) Sigma-1 receptor chaperones at the ER- mitochondrion interface regulate Ca2+ signaling and cell survival. Cell 131:596\u2013610. https:\/\/doi.org\/10.1016\/j.cell.2007.08.036","journal-title":"Cell"},{"key":"4211_CR70","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jphs.2014.11.010","volume":"127","author":"K Hashimoto","year":"2015","unstructured":"Hashimoto K (2015) Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication. J Pharmacol Sci 127:6\u20139. https:\/\/doi.org\/10.1016\/j.jphs.2014.11.010","journal-title":"J Pharmacol Sci"},{"key":"4211_CR71","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1242\/jcs.080762","volume":"124","author":"R Bravo","year":"2011","unstructured":"Bravo R, Vicencio JM, Parra V et al (2011) Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci 124:2143\u20132152. https:\/\/doi.org\/10.1242\/jcs.080762","journal-title":"J Cell Sci"},{"issue":"80","key":"4211_CR72","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.1099793","volume":"305","author":"T Koshiba","year":"2004","unstructured":"Koshiba T, Detmer SA, Kaiser JT et al (2004) Structural basis of mitochondrial tethering by mitofusin complexes. Science 305(80):858\u2013862. https:\/\/doi.org\/10.1126\/science.1099793","journal-title":"Science"},{"key":"4211_CR73","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01565","author":"N Ishihara","year":"2004","unstructured":"Ishihara N, Eura Y, Mihara K (2004) Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.01565","journal-title":"J Cell Sci"},{"key":"4211_CR74","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.266585","author":"Y Chen","year":"2012","unstructured":"Chen Y, Csord\u00e1s G, Jowdy C et al (2012) Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca2+ crosstalk. Circ Res. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.266585","journal-title":"Circ Res"},{"key":"4211_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.003","author":"M Schneeberger","year":"2013","unstructured":"Schneeberger M, Dietrich MO, Sebasti\u00e1n D et al (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell. https:\/\/doi.org\/10.1016\/j.cell.2013.09.003","journal-title":"Cell"},{"key":"4211_CR76","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ceca.2014.11.002","volume":"57","author":"A Ainbinder","year":"2015","unstructured":"Ainbinder A, Boncompagni S, Protasi F, Dirksen RT (2015) Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle. Cell Calcium 57:14\u201324. https:\/\/doi.org\/10.1016\/j.ceca.2014.11.002","journal-title":"Cell Calcium"},{"key":"4211_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/nature07534","author":"OM De Brito","year":"2008","unstructured":"De Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. https:\/\/doi.org\/10.1038\/nature07534","journal-title":"Nature"},{"key":"4211_CR78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046293","author":"P Cosson","year":"2012","unstructured":"Cosson P, Marchetti A, Ravazzola M, Orci L (2012) Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0046293","journal-title":"PLoS ONE"},{"key":"4211_CR79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504880112","author":"R Filadi","year":"2015","unstructured":"Filadi R, Greotti E, Turacchio G et al (2015) Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.1504880112","journal-title":"Proc Natl Acad Sci USA"},{"key":"4211_CR80","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1242\/jcs.114.5.867","volume":"114","author":"A Santel","year":"2001","unstructured":"Santel A, Fuller MT (2001) Control of mitochondrial morphology by a human mitofusin. J Cell Sci 114:867\u2013874","journal-title":"J Cell Sci"},{"key":"4211_CR81","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3389\/fnagi.2018.00366","volume":"10","author":"T Zhu","year":"2018","unstructured":"Zhu T, Chen JL, Wang Q et al (2018) Modulation of mitochondrial dynamics in neurodegenerative diseases: an insight into prion diseases. Front Aging Neurosci 10:366","journal-title":"Front Aging Neurosci"},{"key":"4211_CR82","doi-asserted-by":"publisher","unstructured":"Yoo S-M, Jung Y-K (2018) A molecular approach to mitophagy and mitochondrial dynamics. Mol Cells 41:18\u201326. https:\/\/doi.org\/10.14348\/molcells.2018.2277","DOI":"10.14348\/molcells.2018.2277"},{"key":"4211_CR83","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mito.2017.10.009","volume":"41","author":"J Harris","year":"2018","unstructured":"Harris J, Deen N, Zamani S, Hasnat MA (2018) Mitophagy and the release of inflammatory cytokines. Mitochondrion 41:2\u20138. https:\/\/doi.org\/10.1016\/j.mito.2017.10.009","journal-title":"Mitochondrion"},{"key":"4211_CR84","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0133-4","author":"J Knupp","year":"2019","unstructured":"Knupp J, Arvan P, Chang A (2019) Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress. Cell Death Differ. https:\/\/doi.org\/10.1038\/s41418-018-0133-4","journal-title":"Cell Death Differ"},{"key":"4211_CR85","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2809-5","author":"J Han","year":"2013","unstructured":"Han J, Murthy R, Wood B et al (2013) ER stress signalling through eIF2\u03b1 and CHOP, but not IRE1\u03b1, attenuates adipogenesis in mice. Diabetologia. https:\/\/doi.org\/10.1007\/s00125-012-2809-5","journal-title":"Diabetologia"},{"key":"4211_CR86","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1089\/ars.2009.2625","volume":"11","author":"CXC Santos","year":"2009","unstructured":"Santos CXC, Tanaka LY, Wosniak J, Laurindo FRM (2009) Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 11:2409\u20132427","journal-title":"Antioxid Redox Signal"},{"key":"4211_CR87","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/ijms17091558","volume":"17","author":"E Bahar","year":"2016","unstructured":"Bahar E, Kim H, Yoon H (2016) ER stress-mediated signaling: action potential and Ca2+ as key players. Int J Mol Sci 17:1558. https:\/\/doi.org\/10.3390\/ijms17091558","journal-title":"Int J Mol Sci"},{"key":"4211_CR88","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0329-y","author":"A Carreras-Sureda","year":"2019","unstructured":"Carreras-Sureda A, Ja\u00f1a F, Urra H et al (2019) Non-canonical function of IRE1\u03b1 determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. https:\/\/doi.org\/10.1038\/s41556-019-0329-y","journal-title":"Nat Cell Biol"},{"key":"4211_CR89","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.molcel.2017.05.028","volume":"66","author":"R Bagur","year":"2017","unstructured":"Bagur R, Hajn\u00f3czky G (2017) Intracellular Ca2+ sensing: its role in calcium homeostasis and signaling. Mol Cell 66:780\u2013788. https:\/\/doi.org\/10.1016\/j.molcel.2017.05.028","journal-title":"Mol Cell"},{"key":"4211_CR90","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.040","author":"S De La Fuente","year":"2018","unstructured":"De La Fuente S, Lambert JP, Nichtova Z et al (2018) Spatial separation of mitochondrial calcium uptake and extrusion for energy-efficient mitochondrial calcium signaling in the heart. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2018.08.040","journal-title":"Cell Rep"},{"key":"4211_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60177-1","author":"B Wacquier","year":"2020","unstructured":"Wacquier B, Combettes L, Dupont G (2020) Dual dynamics of mitochondrial permeability transition pore opening. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-020-60177-1","journal-title":"Sci Rep"},{"key":"4211_CR92","doi-asserted-by":"crossref","unstructured":"Fribley A, Zhang K, Kaufman RJ (2009) Regulation of apoptosis by the unfolded protein response. In: Erhardt P, Toth A (eds) Methods in molecular biology (Clifton, N.J.). Humana Press, Totowa, pp 191\u2013204","DOI":"10.1007\/978-1-60327-017-5_14"},{"key":"4211_CR93","doi-asserted-by":"publisher","unstructured":"Beretta M, Santos CX, Molenaar C, et al (2020) Nox4 regulates InsP 3 receptor\u2010dependent Ca 2+ release into mitochondria to promote cell survival. EMBO J. https:\/\/doi.org\/10.15252\/embj.2019103530","DOI":"10.15252\/embj.2019103530"},{"key":"4211_CR94","doi-asserted-by":"publisher","unstructured":"Hamilton C, Anand PK (2019) Right place, right time: localisation and assembly of the NLRP3 inflammasome. F1000Research 8:676. https:\/\/doi.org\/10.12688\/f1000research.18557.1","DOI":"10.12688\/f1000research.18557.1"},{"key":"4211_CR95","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.4049\/jimmunol.170.6.3029","volume":"170","author":"D Brough","year":"2003","unstructured":"Brough D, Le Feuvre RA, Wheeler RD et al (2003) Ca 2+ stores and Ca 2+ entry differentially contribute to the release of IL-1\u03b2 and IL-1\u03b1 from murine macrophages. J Immunol 170:3029\u20133036. https:\/\/doi.org\/10.4049\/jimmunol.170.6.3029","journal-title":"J Immunol"},{"key":"4211_CR96","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1242\/jcs.124388","volume":"126","author":"K Triantafilou","year":"2013","unstructured":"Triantafilou K, Hughes TR, Triantafilou M, Morgan BP (2013) The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. J Cell Sci 126:2903\u20132913. https:\/\/doi.org\/10.1242\/jcs.124388","journal-title":"J Cell Sci"},{"key":"4211_CR97","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.molmed.2020.06.005","volume":"26","author":"M Rashidi","year":"2020","unstructured":"Rashidi M, Wicks IP, Vince JE (2020) Inflammasomes and cell death: common pathways in microparticle diseases. Trends Mol Med 26:1003\u20131020","journal-title":"Trends Mol Med"},{"key":"4211_CR98","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0374-9","author":"RE Tweedell","year":"2020","unstructured":"Tweedell RE, Malireddi RKS, Kanneganti TD (2020) A comprehensive guide to studying inflammasome activation and cell death. Nat Protoc. https:\/\/doi.org\/10.1038\/s41596-020-0374-9","journal-title":"Nat Protoc"},{"issue":"80","key":"4211_CR99","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.aar7607","volume":"362","author":"S R\u00fchl","year":"2018","unstructured":"R\u00fchl S, Shkarina K, Demarco B et al (2018) ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science 362(80):956\u2013960. https:\/\/doi.org\/10.1126\/science.aar7607","journal-title":"Science"},{"key":"4211_CR100","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1017\/S1092852918001499","volume":"24","author":"C Fourrier","year":"2019","unstructured":"Fourrier C, Singhal G, Baune BT (2019) Neuroinflammation and cognition across psychiatric conditions. CNS Spectr 24:4\u201315","journal-title":"CNS Spectr"},{"key":"4211_CR101","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/S2215-0366(20)30255-8","volume":"7","author":"JH Meyer","year":"2020","unstructured":"Meyer JH, Cervenka S, Kim MJ et al (2020) Neuroinflammation in psychiatric disorders: PET imaging and promising new targets. The Lancet Psychiatry 7:1064\u20131074","journal-title":"The Lancet Psychiatry"},{"key":"4211_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1536012118792317","volume":"17","author":"V Narayanaswami","year":"2018","unstructured":"Narayanaswami V, Dahl K, Bernard-Gauthier V et al (2018) Emerging PET radiotracers and targets for imaging of neuroinflammation in neurodegenerative diseases: Outlook beyond TSPO. Mol Imaging 17:1\u201325","journal-title":"Mol Imaging"},{"key":"4211_CR103","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1471-4159.2011.07481.x","volume":"119","author":"R Hanamsagar","year":"2011","unstructured":"Hanamsagar R, Torres V, Kielian T (2011) Inflammasome activation and IL-1\u03b2\/IL-18 processing are influenced by distinct pathways in microglia. J Neurochem 119:736\u2013748. https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07481.x","journal-title":"J Neurochem"},{"key":"4211_CR104","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/jnc.14225","volume":"143","author":"H Scheiblich","year":"2017","unstructured":"Scheiblich H, Schl\u00fctter A, Golenbock DT et al (2017) Activation of the NLRP3 inflammasome in microglia: the role of ceramide. J Neurochem 143:534\u2013550. https:\/\/doi.org\/10.1111\/jnc.14225","journal-title":"J Neurochem"},{"key":"4211_CR105","doi-asserted-by":"publisher","first-page":"e55375","DOI":"10.1371\/journal.pone.0055375","volume":"8","author":"G Codolo","year":"2013","unstructured":"Codolo G, Plotegher N, Pozzobon T et al (2013) Triggering of inflammasome by aggregated \u03b1-synuclein, an inflammatory response in synucleinopathies. PLoS ONE 8:e55375. https:\/\/doi.org\/10.1371\/journal.pone.0055375","journal-title":"PLoS ONE"},{"key":"4211_CR106","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle A, Hornung V, Petzold GC et al (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-\u03b2. Nat Immunol 9:857\u2013865. https:\/\/doi.org\/10.1038\/ni.1636","journal-title":"Nat Immunol"},{"key":"4211_CR107","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1186\/1742-2094-9-73","volume":"9","author":"F Shi","year":"2012","unstructured":"Shi F, Yang L, Kouadir M et al (2012) The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. J Neuroinflammation 9:570. https:\/\/doi.org\/10.1186\/1742-2094-9-73","journal-title":"J Neuroinflammation"},{"key":"4211_CR108","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","volume":"137","author":"I-C Stancu","year":"2019","unstructured":"Stancu I-C, Cremers N, Vanrusselt H et al (2019) Aggregated Tau activates NLRP3\u2013ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo. Acta Neuropathol 137:599\u2013617. https:\/\/doi.org\/10.1007\/s00401-018-01957-y","journal-title":"Acta Neuropathol"},{"key":"4211_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010042","author":"IMN Molagoda","year":"2020","unstructured":"Molagoda IMN, Lee KT, Choi YH, Kim GY (2020) Anthocyanins from Hibiscus syriacus L. Inhibit oxidative stress-mediated apoptosis by activating the Nrf2\/HO-1 signaling pathway. Antioxidants. https:\/\/doi.org\/10.3390\/antiox9010042","journal-title":"Antioxidants"},{"key":"4211_CR110","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pbb.2018.12.006","volume":"177","author":"GR Fries","year":"2019","unstructured":"Fries GR, Walss-Bass C, Bauer ME, Teixeira AL (2019) Revisiting inflammation in bipolar disorder. Pharmacol Biochem Behav 177:12\u201319","journal-title":"Pharmacol Biochem Behav"},{"key":"4211_CR111","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0293-4","author":"G Scaini","year":"2019","unstructured":"Scaini G, Barichello T, Fries GR et al (2019) TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation. Neuropsychopharmacology. https:\/\/doi.org\/10.1038\/s41386-018-0293-4","journal-title":"Neuropsychopharmacology"},{"key":"4211_CR112","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jpsychires.2015.10.015","volume":"72","author":"HK Kim","year":"2016","unstructured":"Kim HK, Andreazza AC, Elmi N et al (2016) Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: a potential mediator between mitochondria and immune-activation. J Psychiatr Res 72:43\u201350. https:\/\/doi.org\/10.1016\/j.jpsychires.2015.10.015","journal-title":"J Psychiatr Res"},{"key":"4211_CR113","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jpsychires.2017.03.018","volume":"92","author":"P Sayana","year":"2017","unstructured":"Sayana P, Colpo GD, Sim\u00f5es LR et al (2017) A systemic review of evidence for the role of inflammatory biomarkers in bipolar patients. J Psychiatr Res 92:160\u2013182","journal-title":"J Psychiatr Res"},{"key":"4211_CR114","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1503\/jpn.100080","volume":"36","author":"J S\u00f6derlund","year":"2011","unstructured":"S\u00f6derlund J, Olsson S, Samuelsson M et al (2011) Elevation of cerebrospinal fluid interleukin-1\u03b2 in bipolar disorder. J Psychiatry Neurosci 36:114\u2013118. https:\/\/doi.org\/10.1503\/jpn.100080","journal-title":"J Psychiatry Neurosci"},{"key":"4211_CR115","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.04.017","author":"P Magioncalda","year":"2018","unstructured":"Magioncalda P, Martino M, Tardito S et al (2018) White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: combined DTI and immunological investigation in the different phases of bipolar disorder. Brain Behav Immun. https:\/\/doi.org\/10.1016\/j.bbi.2018.04.017","journal-title":"Brain Behav Immun"},{"key":"4211_CR116","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.01.022","author":"K Munkholm","year":"2018","unstructured":"Munkholm K, Jacoby AS, Lenskjold T et al (2018) Leukocytes in peripheral blood in patients with bipolar disorder\u2014trait and state alterations and association with levels of cytokines and C-reactive protein. Psychiatry Res. https:\/\/doi.org\/10.1016\/j.psychres.2018.01.022","journal-title":"Psychiatry Res"},{"key":"4211_CR117","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu021","author":"IG Barbosa","year":"2015","unstructured":"Barbosa IG, Rocha NP, Assis F et al (2015) Monocyte and lymphocyte activation in bipolar disorder: a new piece in the puzzle of immune dysfunction in mood disorders. Int J Neuropsychopharmacol. https:\/\/doi.org\/10.1093\/ijnp\/pyu021","journal-title":"Int J Neuropsychopharmacol"},{"key":"4211_CR118","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1001\/jama.293.20.2528","volume":"293","author":"DJ Kupfer","year":"2005","unstructured":"Kupfer DJ (2005) The increasing medical burden in bipolar disorder. JAMA 293:2528. https:\/\/doi.org\/10.1001\/jama.293.20.2528","journal-title":"JAMA"},{"key":"4211_CR119","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jad.2016.12.059","volume":"211","author":"A SayuriYamagata","year":"2017","unstructured":"SayuriYamagata A, Brietzke E, Rosenblat JD et al (2017) Medical comorbidity in bipolar disorder: the link with metabolic-inflammatory systems. J Affect Disord 211:99\u2013106. https:\/\/doi.org\/10.1016\/j.jad.2016.12.059","journal-title":"J Affect Disord"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04211-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04211-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04211-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T04:24:29Z","timestamp":1651033469000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-022-04211-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":119,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["4211"],"URL":"https:\/\/doi.org\/10.1007\/s00018-022-04211-7","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,28]]},"assertion":[{"value":"8 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Human peripheral blood was collected by vein puncture from male BD patients and healthy gender- and age-matched controls, upon written informed consent and approval of the study by the Ethical Committee from Hospitals from University of Coimbra (CHUC), Portugal (150\/CES, July 3<sup>rd<\/sup>).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"213"}}