{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:27:37Z","timestamp":1773494857103,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s00109-013-1022-4","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T11:33:33Z","timestamp":1367408013000},"page":"1013-1023","source":"Crossref","is-referenced-by-count":14,"title":["Gene expression profiling and association studies implicate the neuregulin signaling pathway in Beh\u00e7et's disease susceptibility"],"prefix":"10.1007","volume":"91","author":[{"given":"Joana M.","family":"Xavier","sequence":"first","affiliation":[]},{"given":"Tiago","family":"Krug","sequence":"additional","affiliation":[]},{"given":"Fereydoun","family":"Davatchi","sequence":"additional","affiliation":[]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[]},{"given":"Benedita V.","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Gorete","family":"Jesus","sequence":"additional","affiliation":[]},{"given":"Filipe","family":"Barcelos","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Vedes","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Salgado","sequence":"additional","affiliation":[]},{"given":"Bahar Sadeghi","family":"Abdollahi","sequence":"additional","affiliation":[]},{"given":"Abdolhadi","family":"Nadji","sequence":"additional","affiliation":[]},{"given":"Maria Francisca","family":"Moraes-Fontes","sequence":"additional","affiliation":[]},{"given":"Niloofar Mojarad","family":"Shafiee","sequence":"additional","affiliation":[]},{"given":"Fahmida","family":"Ghaderibarmi","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Vaz Patto","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Crespo","sequence":"additional","affiliation":[]},{"given":"Sofia A.","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,4,27]]},"reference":[{"key":"1022_CR1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10067-010-1491-6","volume":"29","author":"VD Kapsimali","year":"2010","unstructured":"Kapsimali VD, Kanakis MA, Vaiopoulos GA, Kaklamanis PG (2010) Etiopathogenesis of Beh\u00e7et's disease with emphasis on the role of immunological aberrations. Clin Rheumatol 29:1211\u20131216","journal-title":"Clin Rheumatol"},{"key":"1022_CR2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","volume":"42","author":"EF Remmers","year":"2010","unstructured":"Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A et al (2010) Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh\u00e7et's disease. Nat Genet 42:698\u2013702","journal-title":"Nat Genet"},{"key":"1022_CR3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","volume":"42","author":"N Mizuki","year":"2010","unstructured":"Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K et al (2010) Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh\u00e7et's disease susceptibility loci. Nat Genet 42:703\u2013706","journal-title":"Nat Genet"},{"key":"1022_CR4","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1136\/ard.2003.017194","volume":"63","author":"N Olsen","year":"2004","unstructured":"Olsen N, Sokka T, Seehorn CL, Kraft B, Maas K, Moore J, Aune TM (2004) A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis 63:1387\u20131392","journal-title":"Ann Rheum Dis"},{"key":"1022_CR5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.20008","volume":"55","author":"A Achiron","year":"2004","unstructured":"Achiron A, Gurevich M, Friedman N, Kaminski N, Mandel M (2004) Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann Neurol 55:410\u2013417","journal-title":"Ann Neurol"},{"key":"1022_CR6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2249.2004.02587.x","volume":"138","author":"M Mandel","year":"2004","unstructured":"Mandel M, Gurevich M, Pauzner R, Kaminski N, Achiron A (2004) Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus. Clin Exp Immunol 138:164\u2013170","journal-title":"Clin Exp Immunol"},{"issue":"Suppl 42","key":"1022_CR7","first-page":"S14","volume":"24","author":"International Team for the Revision of the International Criteria for Beh\u00e7et's Disease (ITR-ICBD)","year":"2006","unstructured":"International Team for the Revision of the International Criteria for Beh\u00e7et's Disease (ITR-ICBD) (2006) Revision of the International Criteria for Beh\u00e7et's Disease (ICBD). Clin Exp Rheumatol 24(Suppl 42):S14\u2013S15","journal-title":"Clin Exp Rheumatol"},{"key":"1022_CR8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ygeno.2005.06.007","volume":"86","author":"HR Quian","year":"2005","unstructured":"Quian HR, Huang S (2005) Comparison of false discovery rate methods in identifying genes with differential expression. Genomics 86:495\u2013503","journal-title":"Genomics"},{"key":"1022_CR9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng1201-365","volume":"29","author":"A Brazma","year":"2001","unstructured":"Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC et al (2001) Minimum information about a microarray experiment (MIAME): toward standards for microarray data. Nat Genet 29:365\u2013371","journal-title":"Nat Genet"},{"key":"1022_CR10","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1002\/art.34437","volume":"64","author":"JM Xavier","year":"2012","unstructured":"Xavier JM, Shahram F, Davatchi F, Rosa A, Crespo J, Abdollahi BS, Nadji A, Jesus G, Barcelos F, Vaz Patto J et al (2012) Association study of IL10 and IL23R-IL12RB2 in Iranian Beh\u00e7et's disease patients. Arthritis Rheum 64:2761\u20132772","journal-title":"Arthritis Rheum"},{"key":"1022_CR11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263\u2013265","journal-title":"Bioinformatics"},{"key":"1022_CR12","first-page":"644","volume":"23","author":"JR Gonz\u00e1lez","year":"2007","unstructured":"Gonz\u00e1lez JR, Armengol L, Sol\u00e9 X, Guin\u00f3 E, Mercader JM, Estivill X, Moreno V (2007) SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23:644\u2013645","journal-title":"Bioinformatics"},{"key":"1022_CR13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1086\/321276","volume":"69","author":"MD Ritchie","year":"2001","unstructured":"Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 69:138\u2013147","journal-title":"Am J Hum Genet"},{"key":"1022_CR14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559\u2013575","journal-title":"Am J Hum Genet"},{"key":"1022_CR15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1586\/14737159.4.6.795","volume":"4","author":"JH Moore","year":"2004","unstructured":"Moore JH (2004) Computational analysis of gene\u2013gene interactions using multifactor dimensionality reduction. Expert Rev Mol Diagn 4:795\u2013803","journal-title":"Expert Rev Mol Diagn"},{"key":"1022_CR16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10067-010-1430-6","volume":"29","author":"F Davatchi","year":"2010","unstructured":"Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M, Faezi T, Ghodsi Z, Faridar A, Ashofteh F et al (2010) Beh\u00e7et's disease: from east to west. Clin Rheumatol 29:823\u2013833","journal-title":"Clin Rheumatol"},{"key":"1022_CR17","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1002\/art.37708","volume":"64","author":"S Hou","year":"2012","unstructured":"Hou S, Yang Z, Du L, Jiang Z, Shu Q, Chen Y, Li F, Zhou Q, Ohno S, Chen R et al (2012) Identification of a susceptibility locus in STAT4 for Beh\u00e7et's disease in Han Chinese in a genome-wide association study. Arthritis Rheum 64:4104\u20134013","journal-title":"Arthritis Rheum"},{"key":"1022_CR18","doi-asserted-by":"crossref","unstructured":"Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Song R, Kang YM, Kang SW, Baek HJ, Kitaichi N et al (2013) Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Ann Rheum Dis. doi: 10.1136\/annrheumdis-2011-200288","DOI":"10.1136\/annrheumdis-2011-200288"},{"key":"1022_CR19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0014-4827(02)00102-7","volume":"284","author":"DL Falls","year":"2003","unstructured":"Falls DL (2003) Neuregulins: functions, forms, and signaling strategies. Exp Cell Res 284:14\u201330","journal-title":"Exp Cell Res"},{"key":"1022_CR20","doi-asserted-by":"crossref","first-page":"13921","DOI":"10.1073\/pnas.0404217101","volume":"101","author":"S Shirasawa","year":"2004","unstructured":"Shirasawa S, Sugiyama S, Baba I, Inokuchi J, Sekine S, Ogino K, Kawamura Y, Dohi T, Fujimoto M, Sasazuki T (2004) Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A 101:13921\u201313926","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1022_CR21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2005.09.050","volume":"337","author":"S Sugiyama","year":"2005","unstructured":"Sugiyama S, Nakabayashi K, Baba I, Sasazuki T, Shirasawa S (2005) Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Biochem Biophys Res Commun 337:271\u2013274","journal-title":"Biochem Biophys Res Commun"},{"key":"1022_CR22","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.2466334","volume":"243","author":"M Shoyab","year":"1989","unstructured":"Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ (1989) Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science 243:1074\u20131076","journal-title":"Science"},{"key":"1022_CR23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/dnares\/dsi020","volume":"12","author":"T Ishii","year":"2005","unstructured":"Ishii T, Onda H, Tanigawa A, Ohshima S, Fujiwara H, Mima T, Katada Y, Deguchi H, Suemura M, Miyake T et al (2005) Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients. DNA Res 12:429\u2013439","journal-title":"DNA Res"},{"key":"1022_CR24","first-page":"3224","volume":"52","author":"PW Cook","year":"1992","unstructured":"Cook PW, Pittelkow MR, Keeble WW, Graves-Deal R, Coffey RJ Jr, Shipley GD (1992) Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res 52:3224\u20133227","journal-title":"Cancer Res"},{"key":"1022_CR25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-9255-2-15","volume":"2","author":"MR Davies","year":"2005","unstructured":"Davies MR, Harding CJ, Raines S, Tolley K, Parker AE, Downey-Jones M, Needham MR (2005) Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts. J Inflamm 2:15","journal-title":"J Inflamm"},{"key":"1022_CR26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.0906-6705.2004.00183.x","volume":"13","author":"PW Cook","year":"2004","unstructured":"Cook PW, Brown JR, Cornell KA, Pittelkow MR (2004) Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, earlyonset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp Dermatol 13:347\u2013356","journal-title":"Exp Dermatol"},{"key":"1022_CR27","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00109-010-0653-y","volume":"88","author":"K Marballi","year":"2010","unstructured":"Marballi K, Quinones MP, Jimenez F, Escamilla MA, Ravent\u00f3s H, Soto-Bernardini MC, Ahuja SS, Walss-Bass C (2010) In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation. J Mol Med 88:1133\u20131141","journal-title":"J Mol Med"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-1022-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-013-1022-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-1022-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:29:10Z","timestamp":1558585750000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-013-1022-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,27]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["1022"],"URL":"https:\/\/doi.org\/10.1007\/s00109-013-1022-4","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,27]]}}}