{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:26:50Z","timestamp":1769092010681,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Sociedade Portuguesa de Pneumologia","award":["SPP\/Bolsa Novartis 2012"],"award-info":[{"award-number":["SPP\/Bolsa Novartis 2012"]}]},{"name":"Boehringer-Ingelheim","award":["Unrestricted Research Grant (no number)"],"award-info":[{"award-number":["Unrestricted Research Grant (no number)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00109-022-02242-y","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T21:02:12Z","timestamp":1660942932000},"page":"1341-1353","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictive value of common genetic variants in idiopathic pulmonary fibrosis survival"],"prefix":"10.1007","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8157-1125","authenticated-orcid":false,"given":"Patr\u00edcia Caetano","family":"Mota","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-6117","authenticated-orcid":false,"given":"Miguel Luz","family":"Soares","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-4676","authenticated-orcid":false,"given":"Carlos Daniel","family":"Vasconcelos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-8024","authenticated-orcid":false,"given":"Ant\u00f3nio Carlos","family":"Ferreira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-4457","authenticated-orcid":false,"given":"Bruno A.","family":"Lima","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-3714","authenticated-orcid":false,"given":"Elisabetta","family":"Manduchi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-1099","authenticated-orcid":false,"given":"Jason H.","family":"Moore","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8815-0369","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Melo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-4202","authenticated-orcid":false,"given":"H\u00e9lder","family":"Novais-Bastos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-0017","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8628-5195","authenticated-orcid":false,"given":"Susana","family":"Guimar\u00e3es","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-6272","authenticated-orcid":false,"given":"Concei\u00e7\u00e3o Souto","family":"Moura","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-2093","authenticated-orcid":false,"given":"Jos\u00e9 Agostinho","family":"Marques","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8348-8651","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Morais","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"2242_CR1","doi-asserted-by":"publisher","unstructured":"Coward WR, Saini G, Jenkins G (2010) The pathogenesis of idiopathic pulmonary fibrosis. Ther Adv Respir Dis 4:367\u2013388. https:\/\/doi.org\/10.1177\/1753465810379801","DOI":"10.1177\/1753465810379801"},{"key":"2242_CR2","doi-asserted-by":"publisher","unstructured":"Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ et al (2018) Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med 198:e44\u201368. https:\/\/doi.org\/10.1164\/rccm.201807-1255ST","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"2242_CR3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","volume":"134","author":"M Selman","year":"2001","unstructured":"Selman M, King J, Pardo A (2001) Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134:136\u2013151","journal-title":"Ann Intern Med"},{"key":"2242_CR4","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.4155\/fmc-2019-0111","volume":"11","author":"M Lv","year":"2019","unstructured":"Lv M, Liu Y, Ma S, Yu Z (2019) Current advances in idiopathic pulmonary fibrosis: the pathogenesis, therapeutic strategies and candidate molecules. Future Med Chem 11:2595\u20132620. https:\/\/doi.org\/10.4155\/fmc-2019-0111","journal-title":"Future Med Chem"},{"key":"2242_CR5","doi-asserted-by":"publisher","first-page":"9884","DOI":"10.1096\/fj.201902636RR","volume":"34","author":"X Li","year":"2020","unstructured":"Li X, Kim SE, Chen TY, Wang J, Yang X, Tabib T et al (2020) Toll Interacting Protein protects bronchial epithelial cells from bleomycin-induced apoptosis. FASEB J 34:9884. https:\/\/doi.org\/10.1096\/fj.201902636RR","journal-title":"FASEB J"},{"key":"2242_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/S2213-2600(14)70047-5","volume":"2","author":"P Spagnolo","year":"2014","unstructured":"Spagnolo P, Grunewald J, Du Bois RM (2014) Genetic determinants of pulmonary fibrosis: evolving concepts. Lancet Respir Med 2:416\u2013428","journal-title":"Lancet Respir Med"},{"key":"2242_CR7","doi-asserted-by":"crossref","unstructured":"Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y et al (2013) Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med 1:309\u2013317. https:\/\/pubmed.ncbi.nlm.nih.gov\/24429156\/","DOI":"10.1016\/S2213-2600(13)70045-6"},{"key":"2242_CR8","doi-asserted-by":"crossref","unstructured":"Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP et al (2013) Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet 45:613\u2013620. https:\/\/www.nature.com\/articles\/ng.2609","DOI":"10.1038\/ng.2609"},{"key":"2242_CR9","doi-asserted-by":"crossref","unstructured":"Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM et al (2017) Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respir Med 5:869\u2013880. https:\/\/pubmed.ncbi.nlm.nih.gov\/29066090\/","DOI":"10.1016\/S2213-2600(17)30387-9"},{"key":"2242_CR10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3389\/fmed.2018.00116","volume":"5","author":"CA Newton","year":"2018","unstructured":"Newton CA, Molyneaux PL, Oldham JM (2018) Clinical genetics in interstitial lung disease. Front Med 5:116. https:\/\/doi.org\/10.3389\/fmed.2018.00116","journal-title":"Front Med"},{"key":"2242_CR11","doi-asserted-by":"crossref","unstructured":"Coghlan MA, Shifren A, Huang HJ, Russell TD, Mitra RD, Zhang Q et al (2014) Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations. BMJ Open Respir Res 1:e000057. https:\/\/bmjopenrespres.bmj.com\/content\/1\/1\/e000057","DOI":"10.1136\/bmjresp-2014-000057"},{"key":"2242_CR12","doi-asserted-by":"crossref","unstructured":"Petrovski S, Todd JL, Durheim MT, Wang Q, Chien JW, Kelly FL et al (2017) An exome sequencing study to assess the role of rare genetic variation in pulmonary fibrosis. Am J Respir Crit Care Med 196:82\u201393. https:\/\/pubmed.ncbi.nlm.nih.gov\/28099038\/","DOI":"10.1164\/rccm.201610-2088OC"},{"key":"2242_CR13","doi-asserted-by":"crossref","unstructured":"Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE et al (2011) A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 364:1503\u20131512. https:\/\/pubmed.ncbi.nlm.nih.gov\/21506741\/","DOI":"10.1056\/NEJMoa1013660"},{"key":"2242_CR14","doi-asserted-by":"publisher","unstructured":"Zhang Y, Noth I, Garcia JGN, Kaminski N (2011) A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. N Engl J Med.364:1576\u20131577. https:\/\/doi.org\/10.1056\/NEJMc1013504","DOI":"10.1056\/NEJMc1013504"},{"key":"2242_CR15","doi-asserted-by":"crossref","unstructured":"Peljto AL, Zhang Y, Fingerlin TE, Shwu-Fan M, Garcia JGN, Richards TJ et al (2013) Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA 309:2232\u20132239. https:\/\/pubmed.ncbi.nlm.nih.gov\/23695349\/","DOI":"10.1001\/jama.2013.5827"},{"key":"2242_CR16","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1152\/physrev.00004.2016","volume":"96","author":"CM Evans","year":"2016","unstructured":"Evans CM, Fingerlin TE, Schwarz MI, Lynch D, Kurche J, Warg L et al (2016) Idiopathic pulmonary fibrosis: a genetic disease that involves mucociliary dysfunction of the peripheral airways. Physiol Rev 96:1567\u20131591. https:\/\/doi.org\/10.1152\/physrev.00004.2016","journal-title":"Physiol Rev"},{"key":"2242_CR17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.annepidem.2003.09.013","volume":"14","author":"E Ramos","year":"2004","unstructured":"Ramos E, Lopes C, Barros H (2004) Investigating the effect of nonparticipation using a population-based case\u2013control study on myocardial infarction. Ann Epidemiol 14:437\u2013441","journal-title":"Ann Epidemiol"},{"key":"2242_CR18","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","volume":"183","author":"G Raghu","year":"2011","unstructured":"Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK et al (2011) An Official ATS\/ERS\/JRS\/ALAT Statement: Idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183:788\u2013824. https:\/\/doi.org\/10.1164\/rccm.2009-040GL","journal-title":"Am J Respir Crit Care Med"},{"key":"2242_CR19","first-page":"112","volume":"22","author":"C Robalo Cordeiro","year":"2016","unstructured":"Robalo Cordeiro C, Campos P, Carvalho L, Campainha S, Clemente S, Figueiredo L et al (2016) Consensus document for the diagnosis and treatment of idiopathic pulmonary fibrosis: joint consensus of Sociedade Portuguesa de Pneumologia, Sociedade Portuguesa de Radiologia e Medicina Nuclear e Sociedade Portuguesa de Anatomia Patol\u00f3gica. Rev Port Pneumol (English Ed) 22:112\u2013122","journal-title":"Rev Port Pneumol (English Ed)"},{"key":"2242_CR20","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","volume":"192","author":"G Raghu","year":"2015","unstructured":"Raghu G, Rochwerg B, Zhang Y et al (2015) An Official ATS\/ERS\/JRS\/ALAT Clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline [published correction appears in Am J Respir Crit Care Med. 2015 Sep 1;192(5):644. Dosage error in article text]. Am J Respir Crit Care Med 192:e3\u2013e19. https:\/\/doi.org\/10.1164\/rccm.201506-1063ST","journal-title":"Am J Respir Crit Care Med"},{"key":"2242_CR21","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1086\/319501","volume":"68","author":"M Stephens","year":"2001","unstructured":"Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978\u2013989","journal-title":"Am J Hum Genet"},{"key":"2242_CR22","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1086\/428594","volume":"76","author":"M Stephens","year":"2005","unstructured":"Stephens M, Scheet P (2005) Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet 76:449\u2013462. https:\/\/doi.org\/10.1086\/428594","journal-title":"Am J Hum Genet"},{"key":"2242_CR23","doi-asserted-by":"crossref","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263\u2013265. https:\/\/pubmed.ncbi.nlm.nih.gov\/15297300\/","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"2242_CR24","doi-asserted-by":"crossref","unstructured":"Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF et al (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 69:138\u2013147. https:\/\/pubmed.ncbi.nlm.nih.gov\/11404819\/","DOI":"10.1086\/321276"},{"key":"2242_CR25","doi-asserted-by":"publisher","unstructured":"Moore JH, Andrews PC (2015) Epistasis analysis using multifactor dimensionality reduction. Methods Mol Biol 1253:301\u2013314. https:\/\/doi.org\/10.1007\/978-1-4939-2155-3_16","DOI":"10.1007\/978-1-4939-2155-3_16"},{"key":"2242_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1142\/9789814295291_0035","volume":"2010","author":"CS Greene","year":"2010","unstructured":"Greene CS, Himmelstein DS, Nelson HH, Kelsey KT, Williams SM, Andrew AS et al (2010) Enabling personal genomics with an explicit test of epistasis. Pacific Symp Biocomput 2010:327\u2013336. https:\/\/doi.org\/10.1142\/9789814295291_0035","journal-title":"Pacific Symp Biocomput"},{"key":"2242_CR27","doi-asserted-by":"publisher","unstructured":"Moore JH, Hu T (2015) Epistasis analysis using information theory. Methods Mol Biol 1253:257\u2013268. https:\/\/doi.org\/10.1007\/978-1-4939-2155-3_13","DOI":"10.1007\/978-1-4939-2155-3_13"},{"key":"2242_CR28","doi-asserted-by":"crossref","unstructured":"Zhu QQ, Zhang XL, Zhang SM, Tang SW, Min HY, Yi L et al (2015) Association between the MUC5B promoter polymorphism rs35705950 and idiopathic pulmonary fibrosis: a meta-analysis and trial sequential analysis in caucasian and asian populations. Medicine (Baltimore) 94:e1901. https:\/\/pubmed.ncbi.nlm.nih.gov\/26512610\/","DOI":"10.1097\/MD.0000000000001901"},{"key":"2242_CR29","doi-asserted-by":"crossref","unstructured":"Stock CJ, Sato H, Fonseca C, Banya WAS, Molyneaux PL, Adamali H et al (2013) Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis. Thorax 68:436\u2013441. https:\/\/thorax.bmj.com\/content\/68\/5\/436","DOI":"10.1136\/thoraxjnl-2012-201786"},{"key":"2242_CR30","doi-asserted-by":"publisher","unstructured":"Horimasu Y, Ohshimo S, Bonella F, Tanaka S, Ishikawa N, Hattori N et al (2015) MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis. Respirology 20(3):439\u2013444. https:\/\/doi.org\/10.1111\/resp.12466","DOI":"10.1111\/resp.12466"},{"key":"2242_CR31","doi-asserted-by":"crossref","unstructured":"Peljto AL, Selman M, Kim DS, Murphy E, Tucker L, Pardo A, et al (2015) The MUC5B promoter polymorphism is associated with idiopathic pulmonary fibrosis in a Mexican cohort but is rare among Asian ancestries. Chest 147:460\u2013464. https:\/\/pubmed.ncbi.nlm.nih.gov\/25275363\/","DOI":"10.1378\/chest.14-0867"},{"key":"2242_CR32","doi-asserted-by":"publisher","unstructured":"Wang C, Zhuang Y, Guo W, Cao L, Zhang H, Xu L et al (2014) Mucin 5B promoter polymorphism is associated with susceptibility to interstitial lung diseases in Chinese males. PLoS One 9:e104919. https:\/\/doi.org\/10.1371\/journal.pone.0104919","DOI":"10.1371\/journal.pone.0104919"},{"key":"2242_CR33","first-page":"14953","volume":"8","author":"H Jiang","year":"2015","unstructured":"Jiang H, Hu Y, Shang L, Li Y, Yang L, Chen Y (2015) Association between MUC5B polymorphism and susceptibility and severity of idiopathic pulmonary fibrosis. Int J Clin Exp Pathol 8:14953\u201314958","journal-title":"Int J Clin Exp Pathol"},{"key":"2242_CR34","doi-asserted-by":"publisher","unstructured":"Van Der Vis JJ, Snetselaar R, Kazemier KM, Ten Klooster L, Grutters JC, Van Moorsel CHM (2016) Effect of Muc5b promoter polymorphism on disease predisposition and survival in idiopathic interstitial pneumonias. Respirology 21:712\u2013717. https:\/\/doi.org\/10.1111\/resp.12728","DOI":"10.1111\/resp.12728"},{"key":"2242_CR35","doi-asserted-by":"publisher","unstructured":"Bonella F, Campo I, Zorzetto M, Boerner E, Ohshimo S, Theegarten D et al (2021) Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF. Orphanet J Rare Dis 16(1):1\u20139. https:\/\/doi.org\/10.1186\/s13023-021-01750-3","DOI":"10.1186\/s13023-021-01750-3"},{"issue":"12","key":"2242_CR36","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1164\/rccm.201505-1010OC","volume":"192","author":"JM Oldham","year":"2015","unstructured":"Oldham JM, Ma SF, Martinez FJ, Anstrom KJ, Raghu G, Schwartz DA et al (2015) TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 192(12):1475\u20131482. https:\/\/doi.org\/10.1164\/rccm.201505-1010OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2242_CR37","unstructured":"Auton A, Abecasis GR, Altshuler DM, Durbin RM, Bentley DR, Chakravarti A et al (2015) A global reference for human genetic variation. Nature 526:68\u201374. https:\/\/www.nature.com\/articles\/nature15393"},{"key":"2242_CR38","doi-asserted-by":"crossref","unstructured":"Shirali M, Knott SA, Pong-Wong R, Navarro P, Haley CS (2018) Haplotype heritability mapping method uncovers missing heritability of complex traits. Sci Reports 8:1\u20139. https:\/\/www.nature.com\/articles\/s41598-018-23307-4","DOI":"10.1038\/s41598-018-23307-4"},{"key":"2242_CR39","doi-asserted-by":"crossref","unstructured":"Schrodi SJ, Garcia VE, Rowland C, Jones HB (2006) Pairwise linkage disequilibrium under disease models. Eur J Hum Genet 15:212\u2013220. https:\/\/www.nature.com\/articles\/5201731","DOI":"10.1038\/sj.ejhg.5201731"},{"key":"2242_CR40","doi-asserted-by":"crossref","unstructured":"Khankhanian P, Gourraud PA, Lizee A, Goodin DS (2015) Haplotype-based approach to known MS-associated regions increases the amount of explained risk. J Med Genet 52:587\u2013594. https:\/\/pubmed.ncbi.nlm.nih.gov\/26185143\/","DOI":"10.1136\/jmedgenet-2015-103071"},{"key":"2242_CR41","doi-asserted-by":"publisher","unstructured":"Biondini D, Cocconcelli E, Bernardinello N, Lorenzoni G, Rigobello C, Lococo S et al (2021) Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment. Respir Res 22:98. https:\/\/doi.org\/10.1186\/s12931-021-01694-z","DOI":"10.1186\/s12931-021-01694-z"},{"key":"2242_CR42","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1165\/rcmb.2020-0470TR","volume":"64","author":"X Li","year":"2021","unstructured":"Li X, Goobie GC, Gregory AD, Kass DJ, Zhang Y (2021) Toll-interacting protein in pulmonary diseases abiding by the goldilocks principle. Am J Respir Cell Mol Biol 64:536\u2013546. https:\/\/doi.org\/10.1165\/rcmb.2020-0470TR","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2242_CR43","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1378\/chest.112.5.1338","volume":"112","author":"Y Obayashi","year":"1997","unstructured":"Obayashi Y, Yamadori I, Fujita J, Yoshinouchi T, Ueda N, Takahara J (1997) The role of neutrophils in the pathogenesis of idiopathic pulmonary fibrosis. Chest 112:1338\u20131343","journal-title":"Chest"},{"key":"2242_CR44","doi-asserted-by":"crossref","unstructured":"Baumann M, Pham CTN, Benarafa C (2013) SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G. Blood 121:3900\u20133907. http:\/\/ashpublications.org\/blood\/article-pdf\/121\/19\/3900\/1218553\/3900.pdf","DOI":"10.1182\/blood-2012-09-455022"},{"key":"2242_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/420747","volume":"2008","author":"T Hruz","year":"2008","unstructured":"Hruz T, Laule O, Szabo G, Wessendorp F, Bleuler S, Oertle L et al (2008) Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes. Adv Bioinform 2008:420747. https:\/\/doi.org\/10.1155\/2008\/420747","journal-title":"Adv Bioinform"},{"key":"2242_CR46","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/infdis\/jir352","volume":"204","author":"D Gong","year":"2011","unstructured":"Gong D, Farley K, White M, Hartshorn KL, Benarafa C, Remold-O\u2019Donnell E (2011) Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection. J Infect Dis 204:592\u2013600. https:\/\/doi.org\/10.1093\/infdis\/jir352","journal-title":"J Infect Dis"},{"key":"2242_CR47","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1517\/13543784.17.6.905","volume":"17","author":"M Gharaee-Kermani","year":"2008","unstructured":"Gharaee-Kermani M, Hu B, Phan SH, Gyetko MR (2008) The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy. Expert Opin Investig Drugs 17:905\u2013916. https:\/\/doi.org\/10.1517\/13543784.17.6.905","journal-title":"Expert Opin Investig Drugs"},{"key":"2242_CR48","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3390\/ijms22031437","volume":"22","author":"TA Tucker","year":"2021","unstructured":"Tucker TA, Idell S (2021) The contribution of the urokinase plasminogen activator and the urokinase receptor to pleural and parenchymal lung injury and repair: a narrative review. Int J Mol Sci 22:1437. https:\/\/doi.org\/10.3390\/ijms22031437","journal-title":"Int J Mol Sci"},{"key":"2242_CR49","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0272-5231(21)00374-9","volume":"6","author":"S Idell","year":"1985","unstructured":"Idell S, Cohen AB (1985) Bronchoalveolar lavage in patients with the adult respiratory distress syndrome. Clin Chest Med 6:459\u2013471","journal-title":"Clin Chest Med"},{"key":"2242_CR50","doi-asserted-by":"crossref","unstructured":"Chang LC, Tseng JC, Hua CC, Liu YC, Shieh W Bin, Wu HP (2006) Gene polymorphisms of fibrinolytic enzymes in coal workers\u2019 pneumoconiosis. Arch Environ Occup Health 61:61\u201366. https:\/\/pubmed.ncbi.nlm.nih.gov\/17649957\/","DOI":"10.3200\/AEOH.61.2.61-66"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-022-02242-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-022-02242-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-022-02242-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:05:00Z","timestamp":1661328300000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-022-02242-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2242"],"URL":"https:\/\/doi.org\/10.1007\/s00109-022-02242-y","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]},"assertion":[{"value":"14 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o (CHUSJ) (CE-203\u20132012).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all individual participants in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patr\u00edcia Caetano Mota has received speaker fees from Boehringer-Ingelheim and research grants from Boehringer-Ingelheim and Novartis; and has participated in research with Boehringer-Ingelheim and Roche, for which her institution has been remunerated.H\u00e9lder Novais-Bastos and Ant\u00f3nio Morais have attended advisory boards for Boehringer-Ingelheim and Roche; have received speaker fees from Boehringer-Ingelheim and Roche; have participated in research with Boehringer-Ingelheim and Roche, for which their institution has been remunerated. H\u00e9lder Novais-Bastos has also received a research grant from Boehringer-Ingelheim.The remaining authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}