{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T13:15:39Z","timestamp":1773580539734,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["Future Leaders Mentorship Programme"],"award-info":[{"award-number":["Future Leaders Mentorship Programme"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00125-019-05013-6","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T15:07:09Z","timestamp":1572620829000},"page":"206-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Circulating palmitoleic acid is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis"],"prefix":"10.1007","volume":"63","author":[{"name":"for the EGIR-RISC Study Group","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-1346","authenticated-orcid":false,"given":"Domenico","family":"Tric\u00f2","sequence":"first","affiliation":[]},{"given":"Alessandro","family":"Mengozzi","sequence":"additional","affiliation":[]},{"given":"Lorenzo","family":"Nesti","sequence":"additional","affiliation":[]},{"given":"Mensud","family":"Hatunic","sequence":"additional","affiliation":[]},{"given":"Rafael","family":"Gabriel Sanchez","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Konrad","sequence":"additional","affiliation":[]},{"given":"Katarina","family":"Lali\u0107","sequence":"additional","affiliation":[]},{"given":"Neboj\u0161a M.","family":"Lali\u0107","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Mari","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Natali","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"key":"5013_CR1","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1056\/NEJM196304042681404","volume":"268","author":"LH Opie","year":"1963","unstructured":"Opie LH, Walfish PG (1963) Plasma free fatty acid concentrations in obesity. N Engl J Med 268:757\u2013760. https:\/\/doi.org\/10.1056\/NEJM196304042681404","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"5013_CR2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1046\/j.1365-2362.32.s3.3.x","volume":"32","author":"G Boden","year":"2002","unstructured":"Boden G, Shulman GI (2002) Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32(Suppl 3):14\u201323","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"5013_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/00075197-200209000-00014","volume":"5","author":"G Boden","year":"2002","unstructured":"Boden G (2002) Interaction between free fatty acids and glucose metabolism. Curr Opin Clin Nutr Metab Care 5(5):545\u2013549","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"5013_CR4","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00125-017-4534-6","volume":"61","author":"LW Johnston","year":"2018","unstructured":"Johnston LW, Harris SB, Retnakaran R et al (2018) Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort. Diabetologia 61(4):821\u2013830. https:\/\/doi.org\/10.1007\/s00125-017-4534-6","journal-title":"Diabetologia"},{"issue":"4","key":"5013_CR5","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.diabet.2017.04.010","volume":"43","author":"M Seghieri","year":"2017","unstructured":"Seghieri M, Trico D, Natali A (2017) The impact of triglycerides on glucose tolerance: Lipotoxicity revisited. Diabetes Metab 43(4):314\u2013322. https:\/\/doi.org\/10.1016\/j.diabet.2017.04.010","journal-title":"Diabetes Metab"},{"issue":"5","key":"5013_CR6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.plipres.2008.03.003","volume":"47","author":"L Hodson","year":"2008","unstructured":"Hodson L, Skeaff CM, Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47(5):348\u2013380. https:\/\/doi.org\/10.1016\/j.plipres.2008.03.003","journal-title":"Prog Lipid Res"},{"issue":"6","key":"5013_CR7","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.cell.2008.07.048","volume":"134","author":"H Cao","year":"2008","unstructured":"Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS (2008) Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134(6):933\u2013944. https:\/\/doi.org\/10.1016\/j.cell.2008.07.048","journal-title":"Cell"},{"issue":"2","key":"5013_CR8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2337\/dc09-0544","volume":"33","author":"N Stefan","year":"2010","unstructured":"Stefan N, Kantartzis K, Celebi N et al (2010) Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans. Diabetes Care 33(2):405\u2013407. https:\/\/doi.org\/10.2337\/dc09-0544","journal-title":"Diabetes Care"},{"issue":"6","key":"5013_CR9","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.2337\/db11-1810","volume":"61","author":"KE Pinnick","year":"2012","unstructured":"Pinnick KE, Neville MJ, Fielding BA, Frayn KN, Karpe F, Hodson L (2012) Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans. Diabetes 61(6):1399\u20131403. https:\/\/doi.org\/10.2337\/db11-1810","journal-title":"Diabetes"},{"issue":"1","key":"5013_CR10","doi-asserted-by":"publisher","first-page":"E40","DOI":"10.1210\/jc.2012-2892","volume":"98","author":"BC Bergman","year":"2013","unstructured":"Bergman BC, Howard D, Schauer IE et al (2013) The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes. J Clin Endocrinol Metab 98(1):E40\u2013E50. https:\/\/doi.org\/10.1210\/jc.2012-2892","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"5013_CR11","doi-asserted-by":"publisher","first-page":"619","DOI":"10.2174\/1389450117666151209120345","volume":"18","author":"EA Nunes","year":"2017","unstructured":"Nunes EA, Rafacho A (2017) Implications of palmitoleic acid (palmitoleate) on glucose homeostasis, insulin resistance and diabetes. Curr Drug Targets 18(6):619\u2013628. https:\/\/doi.org\/10.2174\/1389450117666151209120345","journal-title":"Curr Drug Targets"},{"issue":"1","key":"5013_CR12","doi-asserted-by":"publisher","first-page":"1700504","DOI":"10.1002\/mnfr.201700504","volume":"62","author":"Camila O. de Souza","year":"2017","unstructured":"de Souza CO, Vannice GK, Rosa Neto JC, Calder PC (2018) Is palmitoleic acid a plausible nonpharmacological strategy to prevent or control chronic metabolic and inflammatory disorders? Mol Nutr Food Res 62(1). https:\/\/doi.org\/10.1002\/mnfr.201700504","journal-title":"Molecular Nutrition & Food Research"},{"issue":"12","key":"5013_CR13","doi-asserted-by":"publisher","first-page":"790","DOI":"10.7326\/0003-4819-153-12-201012210-00005","volume":"153","author":"D Mozaffarian","year":"2010","unstructured":"Mozaffarian D, Cao H, King IB et al (2010) Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Intern Med 153(12):790\u2013799. https:\/\/doi.org\/10.7326\/0003-4819-153-12-201012210-00005","journal-title":"Ann Intern Med"},{"key":"5013_CR14","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/1476-511X-10-120","volume":"10","author":"ZH Yang","year":"2011","unstructured":"Yang ZH, Miyahara H, Hatanaka A (2011) Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay mice with genetic type 2 diabetes. Lipids Health Dis 10:120. https:\/\/doi.org\/10.1186\/1476-511X-10-120","journal-title":"Lipids Health Dis"},{"issue":"3","key":"5013_CR15","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1042\/BJ20060244","volume":"399","author":"N Dimopoulos","year":"2006","unstructured":"Dimopoulos N, Watson M, Sakamoto K, Hundal HS (2006) Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J 399(3):473\u2013481. https:\/\/doi.org\/10.1042\/BJ20060244","journal-title":"Biochem J"},{"issue":"10","key":"5013_CR16","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/nm1662","volume":"13","author":"T Matsuzaka","year":"2007","unstructured":"Matsuzaka T, Shimano H, Yahagi N et al (2007) Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med 13(10):1193\u20131202. https:\/\/doi.org\/10.1038\/nm1662","journal-title":"Nat Med"},{"key":"5013_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/1476-511X-13-199","volume":"13","author":"A Bolsoni-Lopes","year":"2014","unstructured":"Bolsoni-Lopes A, Festuccia WT, Chimin P et al (2014) Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. Lipids Health Dis 13:199. https:\/\/doi.org\/10.1186\/1476-511X-13-199","journal-title":"Lipids Health Dis"},{"issue":"8","key":"5013_CR18","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1002\/jcp.25715","volume":"232","author":"Camila O. de Souza","year":"2017","unstructured":"de Souza CO, Teixeira AAS, Biondo LA, Lima Junior EA, Batatinha HAP, Rosa Neto JC (2017) Palmitoleic acid improves metabolic functions in fatty liver by PPAR\u03b1-dependent AMPK activation. J Cell Physiol 232(8): 2168-2177. https:\/\/doi.org\/10.1002\/jcp.25715","journal-title":"Journal of Cellular Physiology"},{"issue":"3","key":"5013_CR19","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2337\/diabetes.52.3.726","volume":"52","author":"K Maedler","year":"2003","unstructured":"Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY (2003) Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52(3):726\u2013733","journal-title":"Diabetes"},{"issue":"10","key":"5013_CR20","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1007\/BF00400468","volume":"37","author":"B Vessby","year":"1994","unstructured":"Vessby B, Tengblad S, Lithell H (1994) Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia 37(10):1044\u20131050","journal-title":"Diabetologia"},{"issue":"3-4","key":"5013_CR21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.2152\/jmi.54.243","volume":"54","author":"M Kusunoki","year":"2007","unstructured":"Kusunoki M, Tsutsumi K, Nakayama M et al (2007) Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus. J Med Invest 54(3-4):243\u2013247","journal-title":"J Med Invest"},{"issue":"6","key":"5013_CR22","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3945\/ajcn.110.003970","volume":"92","author":"D Mozaffarian","year":"2010","unstructured":"Mozaffarian D, Cao H, King IB et al (2010) Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. Am J Clin Nutr 92(6):1350\u20131358. https:\/\/doi.org\/10.3945\/ajcn.110.003970","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"5013_CR23","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1194\/jlr.M013599","volume":"52","author":"E Fabbrini","year":"2011","unstructured":"Fabbrini E, Magkos F, Su X et al (2011) Insulin sensitivity is not associated with palmitoleate availability in obese humans. J Lipid Res 52(4):808\u2013812. https:\/\/doi.org\/10.1194\/jlr.M013599","journal-title":"J Lipid Res"},{"issue":"3","key":"5013_CR24","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1007\/s00125-004-1335-5","volume":"47","author":"SA Hills","year":"2004","unstructured":"Hills SA, Balkau B, Coppack SW et al (2004) The EGIR-RISC Study (The European Group for the study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular disease risk): I. Methodology and objectives. Diabetologia 47(3):566\u2013570. https:\/\/doi.org\/10.1007\/s00125-004-1335-5","journal-title":"Diabetologia"},{"issue":"Suppl 1","key":"5013_CR25","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc19-S002","volume":"42","author":"American Diabetes Association","year":"2019","unstructured":"American Diabetes Association (2019) Classification and diagnosis of diabetes: standards of medical care in diabetes\u20132019. Diabetes Care 42(Suppl 1):S13\u2013S28. https:\/\/doi.org\/10.2337\/dc19-S002","journal-title":"Diabetes Care"},{"issue":"3","key":"5013_CR26","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2337\/diacare.24.3.539","volume":"24","author":"A. Mari","year":"2001","unstructured":"Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ (2001) A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24(3):539\u2013548","journal-title":"Diabetes Care"},{"issue":"3","key":"5013_CR27","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1007\/s00125-010-1966-7","volume":"54","author":"J Vangipurapu","year":"2011","unstructured":"Vangipurapu J, Stancakova A, Kuulasmaa T et al (2011) A novel surrogate index for hepatic insulin resistance. Diabetologia 54(3):540\u2013543. https:\/\/doi.org\/10.1007\/s00125-010-1966-7","journal-title":"Diabetologia"},{"issue":"3","key":"5013_CR28","doi-asserted-by":"publisher","first-page":"368","DOI":"10.2337\/diab.41.3.368","volume":"41","author":"E Van Cauter","year":"1992","unstructured":"Van Cauter E, Mestrez F, Sturis J, Polonsky KS (1992) Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41(3):368\u2013377","journal-title":"Diabetes"},{"key":"5013_CR29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1463-1326.2008.00946.x","volume":"10","author":"A. Mari","year":"2008","unstructured":"Mari A, Ferrannini E (2008) Beta-cell function assessment from modelling of oral tests: an effective approach. Diabetes Obesity Meta 10(Suppl 4):77\u201387. https:\/\/doi.org\/10.1111\/j.1463-1326.2008.00946.x","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"4","key":"5013_CR30","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00125-009-1647-6","volume":"53","author":"A Mari","year":"2010","unstructured":"Mari A, Tura A, Natali A et al (2010) Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance. Diabetologia 53(4):749\u2013756","journal-title":"Diabetologia"},{"issue":"4","key":"5013_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.diabet.2016.03.004","volume":"42","author":"D Trico","year":"2016","unstructured":"Trico D, Filice E, Baldi S, Frascerra S, Mari A, Natali A (2016) Sustained effects of a protein and lipid preload on glucose tolerance in type 2 diabetes patients. Diabetes Metab 42(4):242\u2013248. https:\/\/doi.org\/10.1016\/j.diabet.2016.03.004","journal-title":"Diabetes Metab"},{"issue":"5","key":"5013_CR32","doi-asserted-by":"publisher","first-page":"e10883","DOI":"10.1371\/journal.pone.0010883","volume":"5","author":"Walter E. Gall","year":"2010","unstructured":"Gall WE, Beebe K, Lawton KA et al (2010) Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One 5(5):e10883. https:\/\/doi.org\/10.1371\/journal.pone.0010883","journal-title":"PLoS ONE"},{"key":"5013_CR33","doi-asserted-by":"publisher","unstructured":"Carta G, Murru E, Banni S, Manca C (2017) Palmitic acid: physiological role, metabolism and nutritional implications. Front Physiol 8:902. https:\/\/doi.org\/10.3389\/fphys.2017.00902","DOI":"10.3389\/fphys.2017.00902"},{"issue":"2","key":"5013_CR34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cmet.2004.12.008","volume":"1","author":"K Maeda","year":"2005","unstructured":"Maeda K, Cao H, Kono K et al (2005) Adipocyte\/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab 1(2):107\u2013119. https:\/\/doi.org\/10.1016\/j.cmet.2004.12.008","journal-title":"Cell Metab"},{"issue":"1","key":"5013_CR35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1677\/joe.0.1730073","volume":"173","author":"C Gravena","year":"2002","unstructured":"Gravena C, Mathias PC, Ashcroft SJ (2002) Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. J Endocrinol 173(1):73\u201380","journal-title":"J Endocrinol"},{"issue":"3","key":"5013_CR36","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.tem.2017.11.009","volume":"29","author":"X Palomer","year":"2018","unstructured":"Palomer X, Pizarro-Delgado J, Barroso E, Vazquez-Carrera M (2018) Palmitic and oleic acid: the yin and yang of fatty acids in type 2 diabetes mellitus. Trends Endocrinol Metab 29(3):178\u2013190. https:\/\/doi.org\/10.1016\/j.tem.2017.11.009","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"5013_CR37","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1017\/S0007114515002251","volume":"114","author":"CG Walker","year":"2015","unstructured":"Walker CG, Browning LM, Stecher L et al (2015) Fatty acid profile of plasma NEFA does not reflect adipose tissue fatty acid profile. Br J Nutr 114(5):756\u2013762. https:\/\/doi.org\/10.1017\/S0007114515002251","journal-title":"Br J Nutr"},{"issue":"2","key":"5013_CR38","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1047-2797(02)00260-0","volume":"13","author":"SF Knutsen","year":"2003","unstructured":"Knutsen SF, Fraser GE, Beeson WL, Lindsted KD, Shavlik DJ (2003) Comparison of adipose tissue fatty acids with dietary fatty acids as measured by 24-hour recall and food frequency questionnaire in Black and White Adventists: the Adventist Health Study. Ann Epidemiol 13(2):119\u2013127","journal-title":"Ann Epidemiol"},{"issue":"6","key":"5013_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.numecd.2006.04.005","volume":"17","author":"AM Hodge","year":"2007","unstructured":"Hodge AM, Simpson JA, Gibson RA et al (2007) Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort. Nutr Metab Cardiovasc Dis 17(6):415\u2013426. https:\/\/doi.org\/10.1016\/j.numecd.2006.04.005","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"5013_CR40","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-2275(20)41179-4","volume":"35","author":"P Nestel","year":"1994","unstructured":"Nestel P, Clifton P, Noakes M (1994) Effects of increasing dietary palmitoleic acid compared with palmitic and oleic acids on plasma lipids of hypercholesterolemic men. J Lipid Res 35(4):656\u2013662","journal-title":"J Lipid Res"},{"issue":"8","key":"5013_CR41","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1001\/archinte.160.8.1154","volume":"160","author":"JD Curb","year":"2000","unstructured":"Curb JD, Wergowske G, Dobbs JC, Abbott RD, Huang B (2000) Serum lipid effects of a high-monounsaturated fat diet based on macadamia nuts. Arch Intern Med 160(8):1154\u20131158","journal-title":"Arch Intern Med"},{"issue":"4","key":"5013_CR42","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1093\/jn\/133.4.1060","volume":"133","author":"ML Garg","year":"2003","unstructured":"Garg ML, Blake RJ, Wills RB (2003) Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J Nutr 133(4):1060\u20131063. https:\/\/doi.org\/10.1093\/jn\/133.4.1060","journal-title":"J Nutr"},{"issue":"Suppl 2","key":"5013_CR43","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1111\/j.1440-1681.2004.04121.x","volume":"31","author":"J Hiraoka-Yamamoto","year":"2004","unstructured":"Hiraoka-Yamamoto J, Ikeda K, Negishi H et al (2004) Serum lipid effects of a monounsaturated (palmitoleic) fatty acid-rich diet based on macadamia nuts in healthy, young Japanese women. Clin Exp Pharmacol Physiol 31(Suppl 2):S37\u2013S38. https:\/\/doi.org\/10.1111\/j.1440-1681.2004.04121.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"4","key":"5013_CR44","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/jn\/138.4.761","volume":"138","author":"AE Griel","year":"2008","unstructured":"Griel AE, Cao Y, Bagshaw DD, Cifelli AM, Holub B, Kris-Etherton PM (2008) A macadamia nut-rich diet reduces total and LDL-cholesterol in mildly hypercholesterolemic men and women. J Nutr 138(4):761\u2013767. https:\/\/doi.org\/10.1093\/jn\/138.4.761","journal-title":"J Nutr"},{"issue":"1","key":"5013_CR45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.plipres.2012.08.002","volume":"52","author":"L Hodson","year":"2013","unstructured":"Hodson L, Fielding BA (2013) Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res 52(1):15\u201342. https:\/\/doi.org\/10.1016\/j.plipres.2012.08.002","journal-title":"Prog Lipid Res"},{"issue":"11","key":"5013_CR46","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1097\/00004872-200411000-00007","volume":"22","author":"D Canoy","year":"2004","unstructured":"Canoy D, Luben R, Welch A et al (2004) Fat distribution, body mass index and blood pressure in 22,090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study. J Hypertens 22(11):2067\u20132074","journal-title":"J Hypertens"},{"issue":"9497","key":"5013_CR47","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/S0140-6736(05)67663-5","volume":"366","author":"S Yusuf","year":"2005","unstructured":"Yusuf S, Hawken S, Ounpuu S et al (2005) Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366(9497):1640\u20131649. https:\/\/doi.org\/10.1016\/S0140-6736(05)67663-5","journal-title":"Lancet"},{"issue":"3","key":"5013_CR48","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/micc.12268","volume":"23","author":"E Venturi","year":"2016","unstructured":"Venturi E, Pinnola S, Morizzo C et al (2016) Clinical phenotype and microvascular dynamics of subjects with endothelial dysfunction as assessed by peripheral tonometry. Microcirculation 23(3):230\u2013239. https:\/\/doi.org\/10.1111\/micc.12268","journal-title":"Microcirculation"},{"issue":"4","key":"5013_CR49","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/s41366-018-0227-6","volume":"43","author":"GR Umano","year":"2019","unstructured":"Umano GR, Shabanova V, Pierpont B et al (2019) A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study. Int J Obes (Lond) 43(4):673\u2013682. https:\/\/doi.org\/10.1038\/s41366-018-0227-6","journal-title":"Int J Obes (Lond)"},{"issue":"5","key":"5013_CR50","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1172\/JCI119628","volume":"100","author":"E Ferrannini","year":"1997","unstructured":"Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G (1997) Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 100(5):1166\u20131173. https:\/\/doi.org\/10.1172\/JCI119628","journal-title":"J Clin Invest"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-019-05013-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-019-05013-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-019-05013-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T18:32:30Z","timestamp":1611685950000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-019-05013-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["5013"],"URL":"https:\/\/doi.org\/10.1007\/s00125-019-05013-6","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,1]]},"assertion":[{"value":"2 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no duality of interest associated with this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}