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This study aimed to evaluate the acute toxicity of rare earth elements (REEs): lanthanum, cerium, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium, and yttrium on the standard aquatic species <jats:italic>Daphnia magna<\/jats:italic> through a toxicity screening approach. Based on EC<jats:sub>50<\/jats:sub> values, the most toxic element was yttrium (EC<jats:sub>50<\/jats:sub>\u2009=\u20097.2 mg L<jats:sup>\u22121<\/jats:sup>), followed by scandium, dysprosium, europium, lutetium, neodymium, holmium, gadolinium, ytterbium, thulium, terbium, samarium, cerium, and lanthanum (10\u2009&gt;\u2009EC<jats:sub>50<\/jats:sub>\u2009&lt;\u2009100) identified as harmful, and praseodymium classified as non-toxic with an EC<jats:sub>50<\/jats:sub> above 100 mg L<jats:sup>\u22121<\/jats:sup> (130.81 mg L<jats:sup>\u22121<\/jats:sup>). This study demonstrates that all REEs, except praseodymium, induce acute effects in <jats:italic>D. magna<\/jats:italic> using ASTM as a culture medium. The results also highlight the need for standardized screening studies to obtain reliable data for both predictive and retrospective environmental risk features.<\/jats:p>","DOI":"10.1007\/s00128-025-04044-7","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:42Z","timestamp":1745625642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["From High-Tech To High-Risk? Unveiling the Acute Ecotoxicological Effects of Rare Earth Elements on Daphnia magna"],"prefix":"10.1007","volume":"114","author":[{"given":"Ivo","family":"Pinto","sequence":"first","affiliation":[]},{"given":"Bruno","family":"Henriques","sequence":"additional","affiliation":[]},{"given":"Thainara","family":"Viana","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-9919","authenticated-orcid":false,"given":"Sara C.","family":"Antunes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"4044_CR1","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.envpol.2018.02.068","volume":"238","author":"E Agathokleous","year":"2018","unstructured":"Agathokleous E, Kitao M, Calabrese EJ (2018) The rare Earth element (REE) lanthanum (La) induces hormesis in plants. 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