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Moreover, the implanted scaffolds have been evaluated by MRI protocol in terms of morphology, volume, and signal intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with symptomatic knee laxity after failed ACL reconstruction and partial medial meniscectomy underwent ACL revision combined with polyurethane\u2010based meniscal scaffold implant. Clinical assessment at 2\u2010 and 5\u2010year follow\u2010ups included VAS, Tegner Activity Score, International Knee Documentation Committee (IKDC), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Lysholm Score. MRI evaluation of the scaffold was performed according to the Genovese scale with quantification of the scaffold\u2019s volume at 1\u2010 and 5\u2010year follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All scores revealed clinical improvement as compared with the preoperative values at the 2\u2010 and 5\u2010year follow\u2010ups. However, a slight, but significant reduction of scores was observed between 2 and 5 years. Concerning the MRI assessment, a significant reduction of the scaffold\u2019s volume was observed between 1 and 5 years. Genovese Morphology classification at 5 years included two complete resorptions (Type 3) and all the remaining patients had irregular morphology (Type 2). With regard to the Genovese Signal at the 5\u2010year follow\u2010up, three were classified as markedly hyperintense (Type 1), 15 as slightly hyperintense (Type 2), and two as isointense (Type 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simultaneous ACL reconstruction and partial meniscus replacement using a polyurethane scaffold provides favourable clinical outcomes in the treatment of symptomatic patients with previously failed ACL reconstruction and partial medial meniscectomy at 5 years. However, MRI evaluation suggests that integration of the scaffold is not consistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Level IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-06946-z","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T23:02:33Z","timestamp":1648249353000},"page":"3422-3427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integration of polyurethane meniscus scaffold during ACL revision is not reliable at 5 years despite favourable clinical outcome"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-6766","authenticated-orcid":false,"given":"H\u00e9lder","family":"Pereira","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> 3B\u2019s Research Group, I3Bs\u2010Research Institute on Biomaterials, Biodegradables and Biomimetics University of Minho 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da Gandra, Barco 4805\u2010017 Guimar\u00e3es Portugal"},{"name":"<!--<label>2<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga\/Guimar\u00e3es Portugal"}]},{"given":"Joana","family":"Silva\u2010Correia","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> 3B\u2019s Research Group, I3Bs\u2010Research Institute on Biomaterials, Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco 4805\u2010017 Guimar\u00e3es Portugal"},{"name":"<!--<label>2<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga\/Guimar\u00e3es Portugal"}]},{"given":"Joaquim M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> 3B\u2019s Research Group, I3Bs\u2010Research Institute on Biomaterials, Biodegradables and Biomimetics University 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