{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:47:10Z","timestamp":1771854430726,"version":"3.50.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T00:00:00Z","timestamp":1291766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00204-010-0630-9","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T06:24:48Z","timestamp":1291703088000},"page":"929-939","source":"Crossref","is-referenced-by-count":24,"title":["Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes"],"prefix":"10.1007","volume":"85","author":[{"given":"Luciana Grazziotin","family":"Rossato","sequence":"first","affiliation":[]},{"given":"Vera Marisa","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Paula Guedes","family":"de Pinho","sequence":"additional","affiliation":[]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Maria","family":"de Lourdes Bastos","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Remi\u00e3o","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,12,8]]},"reference":[{"key":"630_CR1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/sj.ijo.0802879","volume":"29","author":"DB Allison","year":"2005","unstructured":"Allison DB, Cutter G et al (2005) Exactly wich synephrine alkaloids does Citrus aurantium (Bitter Orange) contain? Int J Obes 29:443\u2013446","journal-title":"Int J Obes"},{"key":"630_CR2","first-page":"1099","volume":"12","author":"J Amin","year":"2001","unstructured":"Amin J, Xiao L et al (2001) Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertroph in adult rat ventricular myocytes. J Mol Cell Cardiol 12:1099\u20131104","journal-title":"J Mol Cell Cardiol"},{"key":"630_CR3","unstructured":"Andrade AS, Schmitt GC et al (2009) Gas chromatographic method for analysis of p-synephrine in Citrus aurantium L. products. Chromatographia 69:S225\u2013S229"},{"key":"630_CR4","unstructured":"Arbo MD, Franco MT et al (2008) Screening for in vivo (anti)estrogenic activity of ephedrine and p-synephrine and their natural sorces Ephedra sinica Stapf. (Ephedraceae) and Citrus aurantium L. (Rutaceae) in rats. Arch Toxicol 83:95\u201399"},{"key":"630_CR5","doi-asserted-by":"crossref","unstructured":"Arbo MD, Schmitt GC et al (2009) Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice. Regul Toxicol Pharmacol 54:114\u2013117","DOI":"10.1016\/j.yrtph.2009.03.001"},{"key":"630_CR6","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1016\/j.fct.2008.04.037","volume":"46","author":"MD Arbo","year":"2008","unstructured":"Arbo MD, Larentis ER et al (2008) Concentrations of p-synephrine in fruits and leaves of Citrus species (Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine. Food Chem Toxicol 46:2770\u20132775","journal-title":"Food Chem Toxicol"},{"key":"630_CR7","unstructured":"Blanck HM, Serdula MK et al (2007) Use of nonprescription dietary supplements for weight loss is common among Americans. J Am Diet Assoc 107(3):441\u2013447"},{"issue":"2","key":"630_CR8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1476-5381.1988.tb11449.x","volume":"93","author":"CM Brown","year":"1988","unstructured":"Brown CM, McGrath JC et al (1988) Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors. Br J Pharmacol 93(2):417\u2013429","journal-title":"Br J Pharmacol"},{"key":"630_CR9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1345\/aph.1G488","volume":"40","author":"LT Bui","year":"2006","unstructured":"Bui LT, Nguyen DT et al (2006) Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother 40:53\u201357","journal-title":"Ann Pharmacother"},{"issue":"2\u20133","key":"630_CR10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tox.2004.03.016","volume":"200","author":"M Carvalho","year":"2004","unstructured":"Carvalho M, Remi\u00e3o F et al (2004a) The toxicity of N-methyl-[alpha]-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200(2\u20133):193\u2013203","journal-title":"Toxicology"},{"key":"630_CR11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/tx049960f","volume":"17","author":"M Carvalho","year":"2004","unstructured":"Carvalho M, Remi\u00e3o F et al (2004b) Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro. Chem Res Toxicol 17:623\u2013632","journal-title":"Chem Res Toxicol"},{"issue":"8","key":"630_CR12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tips.2006.06.008","volume":"27","author":"SPC Cole","year":"2006","unstructured":"Cole SPC, Deeley RG (2006) Transport of glutathione and glutathione conjugates by MRP1. Trends Pharmacol Sci 27(8):438\u2013446","journal-title":"Trends Pharmacol Sci"},{"issue":"8","key":"630_CR13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/tx7000916","volume":"20","author":"VM Costa","year":"2007","unstructured":"Costa VM, Silva R et al (2007) Oxidation process of adrenaline in freshly isolated rat cardiomiocytes: formation of adrenochrome, quinoproteins and GSH adduct. Chem Res Toxicol 20(8):1183\u20131191","journal-title":"Chem Res Toxicol"},{"key":"630_CR14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/tx8002577","volume":"22","author":"VM Costa","year":"2009","unstructured":"Costa VM, Ferreira ML et al (2009a) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(Glutathion-S-yl)adrenaline in rat cardiomyocytes. Chem Res Toxicol 22:129\u2013135","journal-title":"Chem Res Toxicol"},{"issue":"1\u20132","key":"630_CR15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tox.2008.12.010","volume":"257","author":"VM Costa","year":"2009","unstructured":"Costa VM, Silva R et al (2009b) Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes. Toxicology 257(1\u20132):70\u201379","journal-title":"Toxicology"},{"key":"630_CR16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tox.2009.03.012","volume":"260","author":"VM Costa","year":"2009","unstructured":"Costa VM, Silva R et al (2009c) Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes. Toxicology 260:84\u201396","journal-title":"Toxicology"},{"key":"630_CR17","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1124\/mol.105.016832","volume":"68","author":"K Engel","year":"2005","unstructured":"Engel K, Wang J (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol 68:1397\u20131407","journal-title":"Mol Pharmacol"},{"key":"630_CR18","doi-asserted-by":"crossref","first-page":"50042","DOI":"10.1074\/jbc.M407913200","volume":"279","author":"K Engel","year":"2004","unstructured":"Engel K, Zhou M et al (2004) Identification and characterization of a novel monoamine transporter in the human brain. J Biol Chem 279:50042\u201350049","journal-title":"J Biol Chem"},{"issue":"1","key":"630_CR19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/01.CIR.78.1.202","volume":"78","author":"M Forman","year":"1988","unstructured":"Forman M, Puett D et al (1988) Glutathione redox pathway and reperfusion injury. Effect of N-acetylcisteyne on infarct size and ventricular function. Circulation 78(1):202\u2013213","journal-title":"Circulation"},{"issue":"8","key":"630_CR20","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1177\/153537020422900802","volume":"229","author":"A Fugh-Berman","year":"2004","unstructured":"Fugh-Berman A, Myers A (2004) Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med 229(8):698\u2013704","journal-title":"Exp Biol Med"},{"issue":"4","key":"630_CR21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4065\/81.4.545","volume":"81","author":"CA Gange","year":"2006","unstructured":"Gange CA, Madias C et al (2006) Variant angina associated with bitter orange in a dietary supplement. Mayo Clin Proc 81(4):545\u2013548","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"630_CR22","first-page":"1003","volume":"14","author":"F Garcia-Carmona","year":"1987","unstructured":"Garcia-Carmona F, Cabanes J et al (1987) Kinetic study of synephrine oxidation by mushwoom tyrosinase. Biochem Int 14(6):1003\u20131013","journal-title":"Biochem Int"},{"key":"630_CR23","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1139\/y02-106","volume":"80","author":"M Ghosh","year":"2002","unstructured":"Ghosh M, Wang HD et al (2002) Tiron exerts effects unrelated to its role as a scavanger os superoxide anion: effects on calcium binding and vascular reponses. Can J Physiol Pharmacol 80:755\u2013760","journal-title":"Can J Physiol Pharmacol"},{"issue":"4","key":"630_CR24","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1089\/jmf.2006.9.572","volume":"9","author":"F Greenway","year":"2006","unstructured":"Greenway F, Jonge-Levitan L et al (2006) Dietary herbal supplements with phenylephrine for weight loss. J Med Food 9(4):572\u2013578","journal-title":"J Med Food"},{"key":"630_CR25","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/CIRCULATIONAHA.105.586107","volume":"113","author":"M Grube","year":"2006","unstructured":"Grube M, Meyer zu Schwabedissen HEU et al (2006) Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5). Circulation 113:1114\u20131122","journal-title":"Circulation"},{"key":"630_CR26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1467-789X.2006.00195.x","volume":"7","author":"S Haaz","year":"2006","unstructured":"Haaz S, Fontaine KR et al (2006) Citrus aurantium and synephrine alkaloids in the treatment of overweigth and obesity: an update. Obes Rev 7:79\u201388","journal-title":"Obes Rev"},{"key":"630_CR27","first-page":"105","volume-title":"Free radicals in biology and medicine","author":"B Halliwell","year":"1998","unstructured":"Halliwell B, Gutteridge JMC (1998) Antioxidant defenses. In: Halliwell B, Gutteridge JMC (eds) Free radicals in biology and medicine. Oxford University, Oxford, pp 105\u2013245"},{"key":"630_CR28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0704785","volume":"136","author":"M Hayger-Zillgen","year":"2002","unstructured":"Hayger-Zillgen M, Bruss M et al (2002) Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2, and hOCT3. Br J Pharmacol 136:829\u2013836","journal-title":"Br J Pharmacol"},{"key":"630_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1550-2783-3-1-35","volume":"3","author":"JR Hoffman","year":"2006","unstructured":"Hoffman JR, Kang J et al (2006) Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr 3:35\u201341","journal-title":"J Int Soc Sports Nutr"},{"issue":"3","key":"630_CR30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2133\/dmpk.23.207","volume":"23","author":"D Iwata","year":"2008","unstructured":"Iwata D, Kato Y et al (2008) Involvement of carnitine\/organic cation transporter OCTN2 in distribution of its substrate carnitine to the heart. Drug Metab Pharmacokinet 23(3):207\u2013215","journal-title":"Drug Metab Pharmacokinet"},{"issue":"8","key":"630_CR31","first-page":"993","volume":"171","author":"S Jordan","year":"2004","unstructured":"Jordan S, Murty M et al (2004) Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. Can Med Assoc J 171(8):993\u2013994","journal-title":"Can Med Assoc J"},{"issue":"7","key":"630_CR32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tips.2004.05.005","volume":"25","author":"H Koepsell","year":"2004","unstructured":"Koepsell H (2004) Polyspecific organic cation transporters: their functions and interactions with drugs. Trends Pharmacol Sci 25(7):375\u2013381","journal-title":"Trends Pharmacol Sci"},{"key":"630_CR33","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11095-007-9254-z","volume":"24","author":"H Koepsell","year":"2007","unstructured":"Koepsell H, Lips K et al (2007) Polyspecific organic cation transporterrs: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24:1227\u20131251","journal-title":"Pharm Res"},{"key":"630_CR34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.mehy.2004.07.021","volume":"64","author":"P Kovacic","year":"2005","unstructured":"Kovacic P, Cooksy AL (2005) Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species. Med Hypotheses 64:357\u2013366","journal-title":"Med Hypotheses"},{"key":"630_CR35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013272","journal-title":"J Biol Chem"},{"key":"630_CR36","unstructured":"Martindale (2004) Phenylephrine. The complete drug reference. London, UK, Electronic version"},{"key":"630_CR37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/FJC.0b013e3181abc288","volume":"54","author":"BF McBride","year":"2009","unstructured":"McBride BF, Yang T et al (2009) The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. J Cardiovasc Pharmacol 54:63\u201371","journal-title":"J Cardiovasc Pharmacol"},{"issue":"8","key":"630_CR38","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4065\/79.8.1059","volume":"78","author":"JM Nasir","year":"2004","unstructured":"Nasir JM, Durning S et al (2004) Exercise-induced syncope associated with QT-prolongation and ephedra-free Xenadrine. Mayo Clin Proc 78(8):1059\u20131062","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"630_CR39","first-page":"589","volume":"25","author":"M Navarro-Sobrino","year":"2010","unstructured":"Navarro-Sobrino M, Lorita J et al (2010) Catecholamine-induced heart injury in mice: differential effects of isoproterenol and phenylephrine. Histol Histopathol 25(5):589\u2013597","journal-title":"Histol Histopathol"},{"issue":"5","key":"630_CR40","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1345\/aph.1D473","volume":"38","author":"DL Nykamp","year":"2004","unstructured":"Nykamp DL, Fackih MN et al (2004) Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother 38(5):812\u2013816","journal-title":"Ann Pharmacother"},{"key":"630_CR41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00408656","volume":"163\u2013164","author":"O Obst","year":"1996","unstructured":"Obst O, Rose H et al (1996) Characterization of catecholamine uptake2 in isolated cardiac myocytes. Mol Cell Biochem 163\u2013164:181\u2013183","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"630_CR42","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0022-3565(24)35167-5","volume":"291","author":"R Ohashi","year":"1999","unstructured":"Ohashi R, Tamai I et al (1999) Na+ dependent carnitine transport by organic cation transporter (OCTNS): its pharmacological and toxicological relevance. J Pharm Exp Ther 291(2):778\u2013784","journal-title":"J Pharm Exp Ther"},{"key":"630_CR43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1179\/135100099101535124","volume":"4","author":"MM Oosthuizen","year":"1999","unstructured":"Oosthuizen MM, Greyling D (1999) Antioxidants suitable for use with chemiluminescence to identify oxyradical species. Redox Rep Commun Free Radic Res 4:277\u2013290","journal-title":"Redox Rep Commun Free Radic Res"},{"key":"630_CR44","unstructured":"Rang HP, Dale MM et al (2007) Rang and Dale\u2019s pharmacology. Churchill Livingstone, pp. 168\u2013189"},{"key":"630_CR45","doi-asserted-by":"crossref","unstructured":"Remi\u00e3o F, Carmo H et al (2001a) Copper enhances isoproterenol toxicity in isolated rat cardiomyocytes. Cardiovasc Toxicol 195\u2013204","DOI":"10.1385\/CT:1:3:195"},{"key":"630_CR46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0887-2333(01)00022-4","volume":"15","author":"F Remi\u00e3o","year":"2001","unstructured":"Remi\u00e3o F, Carmo H et al (2001b) The study of oxidative stress in freshly isolated Ca2+ tolerant cardiomiocytes from the adult rat. Toxicol In Vitro 15:283\u2013287","journal-title":"Toxicol In Vitro"},{"key":"630_CR47","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1021\/tx025518q","volume":"15","author":"F Remi\u00e3o","year":"2002","unstructured":"Remi\u00e3o F, Carvalho M et al (2002) Cu+2 induced isoproterenol oxidation into isoprenochrome in adult rat calcium-tolerant cardiomyocytes. Chem Res Toxicol 15:861\u2013869","journal-title":"Chem Res Toxicol"},{"key":"630_CR48","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1021\/tx049924g","volume":"17","author":"F Remi\u00e3o","year":"2004","unstructured":"Remi\u00e3o F, Rettori D et al (2004) Leucoisoprenochrome-o-semiquinone formation in freshly isolated adult rat cardiomyocytes. Chem Res Toxicol 17:1584\u20131590","journal-title":"Chem Res Toxicol"},{"key":"630_CR49","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jpba.2010.02.022","volume":"52","author":"LG Rossato","year":"2010","unstructured":"Rossato LG, Pinho PG et al (2010) Development and validation of a GC\/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples. J Pharm Biomed Anal 52:721\u2013726","journal-title":"J Pharm Biomed Anal"},{"key":"630_CR50","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.foodchem.2007.12.076","volume":"109","author":"J Santana","year":"2008","unstructured":"Santana J, Sharpless KE et al (2008) Determination of p-synephrine and m-synephrine positional isomers in bitter orange-containing supplements by LC\/UV and LC\/MS\/MS. Food Chem 109:675\u2013682","journal-title":"Food Chem"},{"key":"630_CR51","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/cvr\/cvp216","volume":"84","author":"A Sridhar","year":"2009","unstructured":"Sridhar A, Nishijima Y et al (2009) Chronic heart failure and the substrate for atrial fibrillation. Cardiovasc Res 84:227\u2013236","journal-title":"Cardiovasc Res"},{"issue":"1","key":"630_CR52","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0022-3565(25)24743-7","volume":"257","author":"A Terzic","year":"1991","unstructured":"Terzic A, Vogel SM (1991) On the mecanism of the positive inotropic action of the alpha-adrenoceptor agonist, phenylephrine, in isolated rat left aorta. J Pharmacol Exp Ther 257(1):520\u2013529","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"630_CR53","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1476-5381.1986.tb10271.x","volume":"89","author":"GP Thomas","year":"1986","unstructured":"Thomas GP, Tripathi RM (1986) Effects of alpha-adrenoceptor agonists and antagonists on oubain-induced arrhytmias and cardiac arrest in guinea pig. Br J Pharmacol 89(2):385\u2013388","journal-title":"Br J Pharmacol"},{"issue":"6","key":"630_CR54","first-page":"586","volume":"36","author":"JE Thomas","year":"2009","unstructured":"Thomas JE, Munir JA et al (2009) STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Text Heart Inst J 36(6):586\u2013590","journal-title":"Text Heart Inst J"},{"key":"630_CR55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0005-2736(00)00189-9","volume":"1466","author":"X Wu","year":"2000","unstructured":"Wu X, George R et al (2000) Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochem Biophys Acta 1466:315\u2013327","journal-title":"Biochem Biophys Acta"},{"key":"630_CR56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-3565(24)37769-9","volume":"287","author":"BK Yamamoto","year":"1998","unstructured":"Yamamoto BK, Zhu W (1998) The effects of metamphetamine on the production of free radicals and oxidative stress. J Pharmacol Exp Ther 287:107\u2013114","journal-title":"J Pharmacol Exp Ther"},{"key":"630_CR57","doi-asserted-by":"crossref","first-page":"C253","DOI":"10.1152\/ajpcell.00634.2008","volume":"297","author":"MQ Zheng","year":"2010","unstructured":"Zheng MQ, Tang K et al (2010) Role of gama-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts. Am J Physiol Cell Physiol 297:C253\u2013C262","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-010-0630-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-010-0630-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-010-0630-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:05:35Z","timestamp":1740751535000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-010-0630-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["630"],"URL":"https:\/\/doi.org\/10.1007\/s00204-010-0630-9","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,8]]}}}