{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:52:58Z","timestamp":1773273178504,"version":"3.50.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00204-012-0929-9","type":"journal-article","created":{"date-parts":[[2012,9,22]],"date-time":"2012-09-22T09:14:37Z","timestamp":1348305277000},"page":"111-122","source":"Crossref","is-referenced-by-count":18,"title":["The risky cocktail: what combination effects can we expect between ecstasy and other amphetamines?"],"prefix":"10.1007","volume":"87","author":[{"given":"Diana","family":"Dias da Silva","sequence":"first","affiliation":[]},{"given":"Helena","family":"Carmo","sequence":"additional","affiliation":[]},{"given":"Elisabete","family":"Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,9,23]]},"reference":[{"issue":"9","key":"929_CR1","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1897\/1551-5028(2000)019<2341:POTTOM>2.3.CO;2","volume":"19","author":"R Altenburger","year":"2000","unstructured":"Altenburger R, Backhaus T, Boedeker W, Faust M, Scholze M, Grimme LH (2000) Predictability of the toxicity of multiple chemical mixtures to Vibrio fisheri: mixtures composed of similarly acting chemicals. Environ Toxicol Chem 19(9):2341\u20132347","journal-title":"Environ Toxicol Chem"},{"issue":"9","key":"929_CR2","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1897\/1551-5028(2000)019<2348:POTTOA>2.3.CO;2","volume":"19","author":"T Backhaus","year":"2000","unstructured":"Backhaus T, Altenburger R, Boedeker W, Faust M, Scholze M, Grimme LH (2000a) Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri. Environ Toxicol Chem 19(9):2348\u20132356","journal-title":"Environ Toxicol Chem"},{"issue":"1\u20132","key":"929_CR3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-445X(99)00069-7","volume":"49","author":"T Backhaus","year":"2000","unstructured":"Backhaus T, Scholze M, Grimme LH (2000b) The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri. Aquat Toxicol 49(1\u20132):49\u201361","journal-title":"Aquat Toxicol"},{"issue":"4b","key":"929_CR4","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1476-5381.2011.01453.x","volume":"165","author":"DJ Barbosa","year":"2012","unstructured":"Barbosa DJ, Capela JP, Oliveira JM et al (2012) Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes. Br J Pharmacol 165(4b):1017\u20131033. doi: 10.1111\/j.1476-5381.2011.01453.x","journal-title":"Br J Pharmacol"},{"issue":"4","key":"929_CR5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/hup.766","volume":"21","author":"SP Barrett","year":"2006","unstructured":"Barrett SP, Darredeau C, Pihl RO (2006) Patterns of simultaneous polysubstance use in drug using university students. Hum Psychopharmacol Clin 21(4):255\u2013263. doi: 10.1002\/Hup.766","journal-title":"Hum Psychopharmacol Clin"},{"issue":"Suppl 1","key":"929_CR6","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1016\/S1344-6223(02)00096-2","volume":"5","author":"J Becker","year":"2003","unstructured":"Becker J, Neis P, Rohrich J, Zorntlein S (2003) A fatal paramethoxymethamphetamine intoxication. Leg Med (Tokyo) 5(Suppl 1):S138\u2013S141","journal-title":"Leg Med (Tokyo)"},{"key":"929_CR7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","volume":"26","author":"CI Bliss","year":"1939","unstructured":"Bliss CI (1939) The toxicity of poisons applied jointly. Ann Appl Biol 26:585\u2013615","journal-title":"Ann Appl Biol"},{"issue":"1","key":"929_CR8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.forsciint.2004.07.004","volume":"151","author":"AM Camilleri","year":"2005","unstructured":"Camilleri AM, Caldicott D (2005) Underground pill testing, down under. Forensic Sci Int 151(1):53\u201358. doi: 10.1016\/J.Forsciint.2004.07.004","journal-title":"Forensic Sci Int"},{"issue":"1","key":"929_CR9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.105.092577","volume":"316","author":"JP Capela","year":"2006","unstructured":"Capela JP, Meisel A, Abreu AR et al (2006) Neurotoxicity of ecstasy metabolites in rat cortical neurons, and influence of hyperthermia. J Pharmacol Exp Ther 316(1):53\u201361. doi: 10.1124\/jpet.105.092577","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"929_CR10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s00210-003-0850-0","volume":"369","author":"H Carmo","year":"2004","unstructured":"Carmo H, Hengstler JG, de Boer D et al (2004) Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse. Naunyn Schmiedebergs Arch Pharmacol 369(2):198\u2013205. doi: 10.1007\/S00210-003-0850-0","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"10","key":"929_CR11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00204-002-0381-3","volume":"76","author":"M Carvalho","year":"2002","unstructured":"Carvalho M, Hawksworth G, Milhazes N et al (2002) Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells. Arch Toxicol 76(10):581\u2013588. doi: 10.1007\/S00204-002-0381-3","journal-title":"Arch Toxicol"},{"issue":"2\u20133","key":"929_CR12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tox.2004.03.016","volume":"200","author":"M Carvalho","year":"2004","unstructured":"Carvalho M, Remiao F, Milhazes N et al (2004a) The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200(2\u20133):193\u2013203. doi: 10.1016\/j.tox.2004.03.016","journal-title":"Toxicology"},{"issue":"5","key":"929_CR13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/tx049960f","volume":"17","author":"M Carvalho","year":"2004","unstructured":"Carvalho M, Remiao F, Milhazes N et al (2004b) Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro. Chem Res Toxicol 17(5):623\u2013632. doi: 10.1021\/tx049960f","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"929_CR14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2174\/138920110791591535","volume":"11","author":"M Carvalho","year":"2010","unstructured":"Carvalho M, Pontes H, Remiao F, Bastos ML, Carvalho F (2010) Mechanisms underlying the hepatotoxic effects of ecstasy. Curr Pharm Biotechnol 11(5):476\u2013495","journal-title":"Curr Pharm Biotechnol"},{"key":"929_CR15","author":"M Carvalho","year":"2012","unstructured":"Carvalho M, Carmo H, Costa VM et al (2012) Toxicity of amphetamines: an update. Arch Toxicol. doi: 10.1007\/s00204-012-0815-5","journal-title":"Arch Toxicol"},{"issue":"4","key":"929_CR16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1124\/mol.52.4.648","volume":"52","author":"Q Chen","year":"1997","unstructured":"Chen Q, Cederbaum AI (1997) Menadione cytotoxicity to Hep G2 cells and protection by activation of nuclear factor-kappaB. Mol Pharmacol 52(4):648\u2013657","journal-title":"Mol Pharmacol"},{"issue":"2","key":"929_CR17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuropharm.2005.03.002","volume":"49","author":"KJ Clemens","year":"2005","unstructured":"Clemens KJ, Cornish JL, Li KM, Hunt GE, McGregor IS (2005) MDMA (\u2018Ecstasy\u2019) and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats. Neuropharmacology 49(2):195\u2013207. doi: 10.1016\/j.neuropharm.2005.03.002","journal-title":"Neuropharmacology"},{"issue":"11","key":"929_CR18","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1016\/j.bmc.2010.04.022","volume":"18","author":"SM Cloonan","year":"2010","unstructured":"Cloonan SM, Keating JJ, Corrigan D et al (2010) Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines. Bioorg Med Chem 18(11):4009\u20134031. doi: 10.1016\/J.Bmc.2010.04.022","journal-title":"Bioorg Med Chem"},{"issue":"2\u20133","key":"929_CR19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tox.2010.01.022","volume":"270","author":"JBA Custodio","year":"2010","unstructured":"Custodio JBA, Santos MS, Goncalves DIR et al (2010) Comparative effects of 3,4-methylenedioxymethamphetamine and 4-methylthioamphetamine on rat liver mitochondrial function. Toxicology 270(2\u20133):99\u2013105. doi: 10.1016\/J.Tox.2010.01.022","journal-title":"Toxicology"},{"issue":"9\u201310","key":"929_CR20","first-page":"815","volume":"878","author":"DG da Silva","year":"2010","unstructured":"da Silva DG, de Pinho PG, Pontes H et al (2010) Gas chromatography-ion trap mass spectrometry method for the simultaneous measurement of MDMA (ecstasy) and its metabolites, MDA, HMA, and HMMA in plasma and urine. J Chromatogr, B: Anal Technol Biomed Life Sci 878(9\u201310):815\u2013822. doi: 10.1016\/j.jchromb.2010.01.042","journal-title":"J Chromatogr, B: Anal Technol Biomed Life Sci"},{"issue":"5","key":"929_CR21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/mutage\/11.5.425","volume":"11","author":"F Darroudi","year":"1996","unstructured":"Darroudi F, Meijers CM, Hadjidekova V, Natarajan AT (1996) Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric probe. Mutagenesis 11(5):425\u2013433","journal-title":"Mutagenesis"},{"issue":"3","key":"929_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/00003088-200443030-00002","volume":"43","author":"R Torre de la","year":"2004","unstructured":"de la Torre R, Farre M, Navarro M, Pacifici R, Zuccaro P, Pichini S (2004) Clinical pharmacokinetics of amfetamine and related substances\u2014monitoring in conventional and non-conventional matrices. Clin Pharmacokinet 43(3):157\u2013185","journal-title":"Clin Pharmacokinet"},{"issue":"6","key":"929_CR23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s004140100204","volume":"114","author":"EA Letter De","year":"2001","unstructured":"De Letter EA, Coopman VAE, Cordonnier JACM, Piette MHA (2001) One fatal and seven non-fatal cases of 4-methylthioamphetamine (4-MTA) intoxication: clinico-pathological findings. Int J Legal Med 114(6):352\u2013356","journal-title":"Int J Legal Med"},{"issue":"2\u20133","key":"929_CR24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.forsciint.2003.12.015","volume":"141","author":"EA Letter De","year":"2004","unstructured":"De Letter EA, Bouche MP, Van Bocxlaer JF, Lambert WE, Piette MH (2004) Interpretation of a 3,4-methylenedioxymethamphetamine (MDMA) blood level: discussion by means of a distribution study in two fatalities. Forensic Sci Int 141(2\u20133):85\u201390. doi: 10.1016\/j.forsciint.2003.12.015","journal-title":"Forensic Sci Int"},{"issue":"1","key":"929_CR25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1258\/rsmmsl.46.1.37","volume":"46","author":"EA Letter De","year":"2006","unstructured":"De Letter EA, Piette MHA, Lambert WE, Cordonnier JACM (2006) Amphetamines as potential inducers of fatalities: a review in the district of Ghent from 1976\u20132004. Med Sci Law 46(1):37\u201365","journal-title":"Med Sci Law"},{"issue":"1","key":"929_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138920008783331086","volume":"9","author":"MT Donato","year":"2008","unstructured":"Donato MT, Lahoz A, Castell JV, Gomez-Lechon MJ (2008) Cell lines: a tool for in vitro drug metabolism studies. Curr Drug Metab 9(1):1\u201311","journal-title":"Curr Drug Metab"},{"issue":"4","key":"929_CR27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0006-2952(93)90548-B","volume":"46","author":"H Doostdar","year":"1993","unstructured":"Doostdar H, Grant MH, Melvin WT, Wolf CR, Burke MD (1993) The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells. Biochem Pharmacol 46(4):629\u2013635","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"929_CR28","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2307\/2532957","volume":"51","author":"K Drescher","year":"1995","unstructured":"Drescher K, Boedeker W (1995) Assessment of the combined effects of substances\u2014the relationship between concentration addition and independent action. Biometrics 51(2):716\u2013730","journal-title":"Biometrics"},{"issue":"2","key":"929_CR29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/jat\/24.2.85","volume":"24","author":"SP Elliott","year":"2000","unstructured":"Elliott SP (2000) Fatal poisoning with a new phenylethylamine: 4-methylthioamphetamine (4-MTA). J Anal Toxicol 24(2):85\u201389","journal-title":"J Anal Toxicol"},{"issue":"2","key":"929_CR30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0379-0738(03)00179-8","volume":"135","author":"R Garcia-Repetto","year":"2003","unstructured":"Garcia-Repetto R, Moreno E, Soriano T, Jurado C, Gimenez MP, Menendez M (2003) Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose. Forensic Sci Int 135(2):110\u2013114. doi: 10.1016\/S0379-0738(03)00179-8","journal-title":"Forensic Sci Int"},{"issue":"2","key":"929_CR31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/0269881106063273","volume":"20","author":"S Hayat","year":"2006","unstructured":"Hayat S, Williams RJ, Rattray M (2006) Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. J Psychopharmacol 20(2):257\u2013263. doi: 10.1177\/0269881106063273","journal-title":"J Psychopharmacol"},{"issue":"2","key":"929_CR32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.taap.2003.12.017","volume":"196","author":"A Jimenez","year":"2004","unstructured":"Jimenez A, Jorda EG, Verdaguer E et al (2004) Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicol Appl Pharm 196(2):223\u2013234. doi: 10.1016\/J.Taap.2003.12.017","journal-title":"Toxicol Appl Pharm"},{"issue":"2","key":"929_CR33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1365-2036.1999.00454.x","volume":"13","author":"AL Jones","year":"1999","unstructured":"Jones AL, Simpson KJ (1999) Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. Aliment Pharmacol Ther 13(2):129\u2013133","journal-title":"Aliment Pharmacol Ther"},{"issue":"1\u20133","key":"929_CR34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tox.2004.02.008","volume":"198","author":"S Knasmuller","year":"2004","unstructured":"Knasmuller S, Mersch-Sundermann V, Kevekordes S et al (2004) Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 198(1\u20133):315\u2013328. doi: 10.1016\/j.tox.2004.02.008","journal-title":"Toxicology"},{"key":"929_CR35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF01952257","volume":"114","author":"S Loewe","year":"1926","unstructured":"Loewe S, Muchnik H (1926) Effect of combinations: mathematical basis of the problem. Arch Exp Pathol Pharmakol 114:313\u2013326","journal-title":"Arch Exp Pathol Pharmakol"},{"issue":"2","key":"929_CR36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1177\/014107689909200206","volume":"92","author":"CM Milroy","year":"1999","unstructured":"Milroy CM (1999) Ten years of \u2018ecstasy\u2019. J R Soc Med 92(2):68\u201372","journal-title":"J R Soc Med"},{"issue":"2","key":"929_CR37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jcp.49.2.149","volume":"49","author":"CM Milroy","year":"1996","unstructured":"Milroy CM, Clark JC, Forrest AR (1996) Pathology of deaths associated with \u201cecstasy\u201d and \u201ceve\u201d misuse. J Clin Pathol 49(2):149\u2013153","journal-title":"J Clin Pathol"},{"issue":"4","key":"929_CR38","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.pbb.2011.06.032","volume":"99","author":"WMY Mohamed","year":"2011","unstructured":"Mohamed WMY, Ben Hamida S, Cassel JC, de Vasconcelos AP, Jones BC (2011) MDMA: interactions with other psychoactive drugs. Pharmacol Biochem Behav 99(4):759\u2013774. doi: 10.1016\/J.Pbb.2011.06.032","journal-title":"Pharmacol Biochem Behav"},{"issue":"7","key":"929_CR39","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1360-0443.2011.03399.x","volume":"106","author":"KM Morefield","year":"2011","unstructured":"Morefield KM, Keane M, Felgate P, White JM, Irvine RJ (2011) Pill content, dose and resulting plasma concentrations of 3,4-methylendioxymethamphetamine (MDMA) in recreational \u2018ecstasy\u2019 users. Addiction 106(7):1293\u20131300. doi: 10.1111\/J.1360-0443.2011.03399.X","journal-title":"Addiction"},{"issue":"1","key":"929_CR40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ecoenv.2010.07.010","volume":"74","author":"MD Pavlaki","year":"2011","unstructured":"Pavlaki MD, Pereira R, Loureiro S, Soares AMVM (2011) Effects of binary mixtures on the life traits of Daphnia magna. Ecotoxicol Environ Saf 74(1):99\u2013110. doi: 10.1016\/J.Ecoenv.2010.07.010","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1\u20133","key":"929_CR41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.forsciint.2009.12.019","volume":"197","author":"M Pavlic","year":"2010","unstructured":"Pavlic M, Schubert B, Libiseller K, Oberacher H (2010) Comprehensive identification of active compounds in tablets by flow-injection data-dependent tandem mass spectrometry combined with library search. Forensic Sci Int 197(1\u20133):40\u201347. doi: 10.1016\/J.Forsciint.2009.12.019","journal-title":"Forensic Sci Int"},{"issue":"10","key":"929_CR42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1289\/ehp.00108983","volume":"108","author":"J Payne","year":"2000","unstructured":"Payne J, Rajapakse N, Wilkins M, Kortenkamp A (2000) Prediction and assessment of the effects of mixtures of four xenoestrogens. Environ Health Perspect 108(10):983\u2013987","journal-title":"Environ Health Perspect"},{"issue":"1\u20132","key":"929_CR43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2008.09.009","volume":"254","author":"H Pontes","year":"2008","unstructured":"Pontes H, Sousa C, Silva R et al (2008) Synergistic toxicity of ethanol and MDMA towards primary cultured rat hepatocytes. Toxicology 254(1\u20132):42\u201350. doi: 10.1016\/j.tox.2008.09.009","journal-title":"Toxicology"},{"issue":"2\u20133","key":"929_CR44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tox.2010.02.010","volume":"270","author":"H Pontes","year":"2010","unstructured":"Pontes H, de Pinho PG, Fernandes E et al (2010) Metabolic interactions between ethanol and MDMA in primary cultured rat hepatocytes. Toxicology 270(2\u20133):150\u2013157. doi: 10.1016\/J.Tox.2010.02.010","journal-title":"Toxicology"},{"issue":"2","key":"929_CR45","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/toxsci\/60.2.296","volume":"60","author":"N Rajapakse","year":"2001","unstructured":"Rajapakse N, Ong D, Kortenkamp A (2001) Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens. Toxicol Sci Off J Soc Toxicol 60(2):296\u2013304","journal-title":"Toxicol Sci Off J Soc Toxicol"},{"issue":"9","key":"929_CR46","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1289\/ehp.02110917","volume":"110","author":"N Rajapakse","year":"2002","unstructured":"Rajapakse N, Silva E, Kortenkamp A (2002) Combining xenoestrogens at levels below individual No-observed-effect concentrations dramatically enhances steroid hormone action. Environ Health Perspect 110(9):917\u2013921","journal-title":"Environ Health Perspect"},{"issue":"1","key":"929_CR47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1124\/mol.64.1.113","volume":"64","author":"SL Ripp","year":"2003","unstructured":"Ripp SL, Falkner KC, Pendleton ML, Tamasi V, Prough RA (2003) Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene. Mol Pharmacol 64(1):113\u2013122. doi: 10.1124\/mol.64.1.113","journal-title":"Mol Pharmacol"},{"issue":"2","key":"929_CR48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1897\/1551-5028(2001)020<0448:AGBFMF>2.0.CO;2","volume":"20","author":"M Scholze","year":"2001","unstructured":"Scholze M, Boedeker W, Faust M, Backhaus T, Altenburger R, Grimme LH (2001) A general best-fit method for concentration-response curves and the estimation of low-effect concentrations. Environ Toxicol Chem 20(2):448\u2013457","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"929_CR49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12012-009-9034-6","volume":"9","author":"SK Shenouda","year":"2009","unstructured":"Shenouda SK, Varner KJ, Carvalho F, Lucchesi PA (2009) Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes. Cardiovasc Toxicol 9(1):30\u201338. doi: 10.1007\/S12012-009-9034-6","journal-title":"Cardiovasc Toxicol"},{"issue":"3","key":"929_CR50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/emj.16.3.194","volume":"16","author":"K Sherlock","year":"1999","unstructured":"Sherlock K, Wolff K, Hay AWM, Conner M (1999) Analysis of illicit ecstasy tablets: implications for clinical management in the accident and emergency department. J Accid Emerg Med 16(3):194\u2013197","journal-title":"J Accid Emerg Med"},{"issue":"8","key":"929_CR51","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1021\/es0101227","volume":"36","author":"E Silva","year":"2002","unstructured":"Silva E, Rajapakse N, Kortenkamp A (2002) Something from \u201cnothing\u201d\u2014eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 36(8):1751\u20131756. doi: 10.1021\/Es0101227","journal-title":"Environ Sci Technol"},{"issue":"2","key":"929_CR52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/toxsci\/kfr103","volume":"122","author":"E Silva","year":"2011","unstructured":"Silva E, Rajapakse N, Scholze M, Backhaus T, Ermler S, Kortenkamp A (2011a) Joint effects of heterogeneous estrogenic chemicals in the E-screen-exploring the applicability of concentration addition. Toxicol Sci 122(2):383\u2013394. doi: 10.1093\/Toxsci\/Kfr103","journal-title":"Toxicol Sci"},{"issue":"4","key":"929_CR53","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00204-010-0587-8","volume":"85","author":"R Silva","year":"2011","unstructured":"Silva R, Carmo H, Dinis-Oliveira R et al (2011b) In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells. Arch Toxicol 85(4):315\u2013326. doi: 10.1007\/S00204-010-0587-8","journal-title":"Arch Toxicol"},{"issue":"2","key":"929_CR54","first-page":"141","volume":"11","author":"R Simantov","year":"1997","unstructured":"Simantov R, Tauber M (1997) The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells. FASEB J Off Publ Fed Am Soc Exp Biol 11(2):141\u2013146","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"9","key":"929_CR55","first-page":"1065","volume":"13","author":"G Stumm","year":"1999","unstructured":"Stumm G, Schlegel J, Schafer T et al (1999a) Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. FASEB J Off Publ Fed Am Soc Exp Biol 13(9):1065\u20131072","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"9","key":"929_CR56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1096\/fasebj.13.9.1065","volume":"13","author":"G Stumm","year":"1999","unstructured":"Stumm G, Schlegel J, Schafer T et al (1999b) Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. FASEB J 13(9):1065\u20131072","journal-title":"FASEB J"},{"issue":"13","key":"929_CR57","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3748\/wjg.v18.i13.1485","volume":"18","author":"RX Tang","year":"2012","unstructured":"Tang RX, Kong FY, Fan BF et al (2012) HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module. World J Gastroenterol 18(13):1485\u20131495. doi: 10.3748\/Wjg.V18.I13.1485","journal-title":"World J Gastroenterol"},{"issue":"3","key":"929_CR58","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.drugalcdep.2005.11.016","volume":"83","author":"EE Tanner-Smith","year":"2006","unstructured":"Tanner-Smith EE (2006) Pharmacological content of tablets sold as \u201cecstasy\u201d: results from an online testing service. Drug Alcohol Depend 83(3):247\u2013254. doi: 10.1016\/J.Drugalcdep.2005.11.016","journal-title":"Drug Alcohol Depend"},{"issue":"2\u20133","key":"929_CR59","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.forsciint.2006.03.035","volume":"161","author":"SF Teng","year":"2006","unstructured":"Teng SF, Wu SC, Liu CR, Li JH, Chien CS (2006) Characteristics and trends of 3,4-methylenedioxymethamphetamine (MDMA) tablets found in Taiwan from 2002 to February 2005. Forensic Sci Int 161(2\u20133):202\u2013208. doi: 10.1016\/J.Forsciint.2006.03.035","journal-title":"Forensic Sci Int"},{"issue":"2\u20133","key":"929_CR60","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.forsciint.2007.03.030","volume":"170","author":"M Verschraagen","year":"2007","unstructured":"Verschraagen M, Maes A, Ruiter B, Bosman IJ, Smink BE, Lusthof KJ (2007) Post-mortem cases involving amphetamine-based drugs in the Netherlands\u2014comparison with driving under the influence cases. Forensic Sci Int 170(2\u20133):163\u2013170. doi: 10.1016\/J.Forsciint.2007.03.030","journal-title":"Forensic Sci Int"},{"issue":"2","key":"929_CR61","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1191\/096032799678839707","volume":"18","author":"A Walubo","year":"1999","unstructured":"Walubo A, Seger D (1999) Fatal multi-organ failure after suicidal overdose with MDMA, \u2018Ecstasy\u2019: case report and review of the literature. Hum Exp Toxicol 18(2):119\u2013125","journal-title":"Hum Exp Toxicol"},{"issue":"1","key":"929_CR62","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.drugalcdep.2006.01.002","volume":"84","author":"LT Wu","year":"2006","unstructured":"Wu LT, Schlenger WE, Galvin DM (2006) Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths. Drug Alcohol Depend 84(1):102\u2013113. doi: 10.1016\/J.Drugalcdep.2006.01.002","journal-title":"Drug Alcohol Depend"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-012-0929-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-012-0929-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-012-0929-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:30:01Z","timestamp":1562200201000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-012-0929-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,23]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["929"],"URL":"https:\/\/doi.org\/10.1007\/s00204-012-0929-9","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,23]]}}}