{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:33:05Z","timestamp":1760549585560},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T00:00:00Z","timestamp":1407628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00204-014-1325-4","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T07:59:26Z","timestamp":1407571166000},"page":"1759-1769","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways"],"prefix":"10.1007","volume":"89","author":[{"given":"Diana","family":"Couto","sequence":"first","affiliation":[]},{"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"Gra\u00e7a","family":"Porto","sequence":"additional","affiliation":[]},{"given":"M. Arturo","family":"Lopez-Quintela","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Rivas","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,8,10]]},"reference":[{"key":"1325_CR1","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.2174\/1381612811319370011","volume":"19","author":"M Ahamed","year":"2013","unstructured":"Ahamed M, Alhadlaq HA, Alam J, Khan MA, Ali D, Alarafi S (2013) Iron oxide nanoparticle-induced oxidative stress and genotoxicity in human skin epithelial and lung epithelial cell lines. Curr Pharm Des 19:6681\u20136690","journal-title":"Curr Pharm Des"},{"key":"1325_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-8977-6-1","volume":"6","author":"PL Apopa","year":"2009","unstructured":"Apopa PL, Qian Y, Shao R, Guo NL, Schwegler-Berry D, Pacurari M, Porter D, Shi X, Vallyathan V, Castranova V, Flynn DC (2009) Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol 6:1","journal-title":"Part Fibre Toxicol"},{"key":"1325_CR3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1742-2094-8-79","volume":"8","author":"AD Bachstetter","year":"2011","unstructured":"Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ (2011) Microglial p38alpha MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Abeta). J Neuroinflamm 8:79","journal-title":"J Neuroinflamm"},{"key":"1325_CR4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.toxlet.2012.02.004","volume":"210","author":"M Ban","year":"2012","unstructured":"Ban M, Langonne I, Huguet N, Goutet M (2012) Effect of submicron and nano-iron oxide particles on pulmonary immunity in mice. Toxicol Lett 210:267\u2013275","journal-title":"Toxicol Lett"},{"key":"1325_CR5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/wnan.16","volume":"1","author":"N Beckmann","year":"2009","unstructured":"Beckmann N, Cannet C, Babin AL, Ble FX, Zurbruegg S, Kneuer R, Dousset V (2009) In vivo visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:272\u2013298","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"1325_CR6","doi-asserted-by":"crossref","first-page":"L81","DOI":"10.1152\/ajplung.00051.2010","volume":"300","author":"S Bhattacharyya","year":"2011","unstructured":"Bhattacharyya S, Gutti U, Mercado J, Moore C, Pollard HB, Biswas R (2011) MAPK signaling pathways regulate IL-8 mRNA stability and IL-8 protein expression in cystic fibrosis lung epithelial cell lines. Am J Physiol Lung Cell Mol Physiol 300:L81\u2013L87","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1325_CR7","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/jemt.22251","volume":"76","author":"B Cao","year":"2013","unstructured":"Cao B, Qiu P, Mao C (2013) Mesoporous iron oxide nanoparticles prepared by polyacrylic acid etching and their application in gene delivery to mesenchymal stem cells. Microsc Res Tech 76:936\u2013941","journal-title":"Microsc Res Tech"},{"key":"1325_CR8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2147\/IJN.S12162","volume":"5","author":"BA Chen","year":"2010","unstructured":"Chen BA, Jin N, Wang J, Ding J, Gao C, Cheng J, Xia G, Gao F, Zhou Y, Chen Y, Zhou G, Li X, Zhang Y, Tang M, Wang X (2010) The effect of magnetic nanoparticles of Fe(3)O(4) on immune function in normal ICR mice. Int J Nanomed 5:593\u2013599","journal-title":"Int J Nanomed"},{"key":"1325_CR9","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.2147\/IJN.S36197","volume":"7","author":"JP Chen","year":"2012","unstructured":"Chen JP, Yang PC, Ma YH, Tu SJ, Lu YJ (2012) Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle. Int J Nanomed 7:5137\u20135149","journal-title":"Int J Nanomed"},{"key":"1325_CR10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/eji.1830270125","volume":"27","author":"C Chizzolini","year":"1997","unstructured":"Chizzolini C, Chicheportiche R, Burger D, Dayer JM (1997) Human Th1 cells preferentially induce interleukin (IL)-1beta while Th2 cells induce IL-1 receptor antagonist production upon cell\/cell contact with monocytes. Eur J Immunol 27:171\u2013177","journal-title":"Eur J Immunol"},{"key":"1325_CR11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s00011-007-7126-y","volume":"57","author":"TT Chowdhury","year":"2008","unstructured":"Chowdhury TT, Salter DM, Bader DL, Lee DA (2008) Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression. Inflamm Res 57:306\u2013313","journal-title":"Inflamm Res"},{"key":"1325_CR12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1874312901206010209","volume":"6","author":"AR Clark","year":"2012","unstructured":"Clark AR, Dean JL (2012) The p38 MAPK pathway in rheumatoid arthritis: a sideways look. Open Rheumatol J 6:209\u2013219","journal-title":"Open Rheumatol J"},{"key":"1325_CR13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/bem.21790","volume":"34","author":"KK Comfort","year":"2013","unstructured":"Comfort KK, Maurer EI, Hussain SM (2013) The biological impact of concurrent exposure to metallic nanoparticles and a static magnetic field. Bioelectromagnetics 34:500\u2013511","journal-title":"Bioelectromagnetics"},{"key":"1325_CR14","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.addr.2006.09.013","volume":"58","author":"C Corot","year":"2006","unstructured":"Corot C, Robert P, Idee JM, Port M (2006) Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev 58:1471\u20131504","journal-title":"Adv Drug Deliv Rev"},{"key":"1325_CR15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.toxlet.2013.11.020","volume":"225","author":"D Couto","year":"2014","unstructured":"Couto D, Freitas M, Vilas-Boas V, Dias I, Porto G, Lopez-Quintela MA, Rivas J, Freitas P, Carvalho F, Fernandes E (2014) Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils. Toxicol Lett 225:57\u201365","journal-title":"Toxicol Lett"},{"key":"1325_CR16","doi-asserted-by":"crossref","first-page":"23814","DOI":"10.1074\/jbc.M909695199","volume":"275","author":"R Craig","year":"2000","unstructured":"Craig R, Larkin A, Mingo AM, Thuerauf DJ, Andrews C, McDonough PM, Glembotski CC (2000) p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. J Biol Chem 275:23814\u201323824","journal-title":"J Biol Chem"},{"key":"1325_CR17","doi-asserted-by":"crossref","first-page":"15998","DOI":"10.1074\/jbc.M110.205724","volume":"286","author":"N Dauletbaev","year":"2011","unstructured":"Dauletbaev N, Eklove D, Mawji N, Iskandar M, Di Marco S, Gallouzi IE, Lands LC (2011) Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 mitogen-activated protein kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms. J Biol Chem 286:15998\u201316007","journal-title":"J Biol Chem"},{"key":"1325_CR18","doi-asserted-by":"crossref","first-page":"920","DOI":"10.4049\/jimmunol.160.2.920","volume":"160","author":"AD Foey","year":"1998","unstructured":"Foey AD, Parry SL, Williams LM, Feldmann M, Foxwell BM, Brennan FM (1998) Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42\/44 mitogen-activated protein kinases. J Immunol 160:920\u2013928","journal-title":"J Immunol"},{"key":"1325_CR19","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jneuroim.2004.10.007","volume":"159","author":"N Fukushima","year":"2005","unstructured":"Fukushima N, Nishiura Y, Nakamura T, Yamada Y, Kohno S, Eguchi K (2005) Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy\/tropical spastic paraparesis. J Neuroimmunol 159:196\u2013202","journal-title":"J Neuroimmunol"},{"key":"1325_CR20","doi-asserted-by":"crossref","first-page":"345101","DOI":"10.1088\/0957-4484\/22\/34\/345101","volume":"22","author":"AJ Giustini","year":"2011","unstructured":"Giustini AJ, Ivkov R, Hoopes PJ (2011) Magnetic nanoparticle biodistribution following intratumoral administration. Nanotechnology 22:345101","journal-title":"Nanotechnology"},{"key":"1325_CR21","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.2174\/092986708784911579","volume":"15","author":"A Gomes","year":"2008","unstructured":"Gomes A, Fernandes E, Lima JL, Mira L, Corvo ML (2008) Molecular mechanisms of anti-inflammatory activity mediated by flavonoids. Curr Med Chem 15:1586\u20131605","journal-title":"Curr Med Chem"},{"key":"1325_CR22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/1874312901206010220","volume":"6","author":"M Guma","year":"2012","unstructured":"Guma M, Firestein GS (2012) c-Jun N-terminal kinase in inflammation and rheumatic diseases. Open Rheumatol J 6:220\u2013231","journal-title":"Open Rheumatol J"},{"key":"1325_CR23","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1016\/j.biomaterials.2004.10.012","volume":"26","author":"AK Gupta","year":"2005","unstructured":"Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995\u20134021","journal-title":"Biomaterials"},{"key":"1325_CR24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5483\/BMBRep.2002.35.3.337","volume":"35","author":"SS Han","year":"2002","unstructured":"Han SS, Keum YS, Seo HJ, Surh YJ (2002) Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem Mol Biol 35:337\u2013342","journal-title":"J Biochem Mol Biol"},{"key":"1325_CR25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1128\/CDLI.2.2.209-213.1995","volume":"2","author":"MW Hornef","year":"1995","unstructured":"Hornef MW, Wagner HJ, Kruse A, Kirchner H (1995) Cytokine production in a whole-blood assay after Epstein-Barr virus infection in vivo. Clin Diagn Lab Immunol 2:209\u2013213","journal-title":"Clin Diagn Lab Immunol"},{"key":"1325_CR26","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.vaccine.2010.12.031","volume":"29","author":"K Hu","year":"2011","unstructured":"Hu K, Dou J, Yu F, He X, Yuan X, Wang Y, Liu C, Gu N (2011) An ocular mucosal administration of nanoparticles containing DNA vaccine pRSC-gD-IL-21 confers protection against mucosal challenge with herpes simplex virus type 1 in mice. Vaccine 29:1455\u20131462","journal-title":"Vaccine"},{"key":"1325_CR27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-1759(02)00092-3","volume":"264","author":"R Hussain","year":"2002","unstructured":"Hussain R, Kaleem A, Shahid F, Dojki M, Jamil B, Mehmood H, Dawood G, Dockrell HM (2002) Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population. J Immunol Methods 264:95\u2013108","journal-title":"J Immunol Methods"},{"key":"1325_CR28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00262-005-0049-y","volume":"55","author":"A Ito","year":"2006","unstructured":"Ito A, Honda H, Kobayashi T (2006) Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of \u201cheat-controlled necrosis\u201d with heat shock protein expression. Cancer Immunol Immun 55:320\u2013328","journal-title":"Cancer Immunol Immun"},{"key":"1325_CR29","doi-asserted-by":"crossref","unstructured":"Iversen NK, Frische S, Thomsen K, Laustsen C, Pedersen M, Hansen PB, Bie P, Fresnais J, Berret JF, Baatrup E, Wang T (2013) Superparamagnetic iron oxide polyacrylic acid coated \u03b3-Fe2O3\u00a0nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice. Toxicol Appl Pharm 266:276\u2013288","DOI":"10.1016\/j.taap.2012.10.014"},{"key":"1325_CR30","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/infdis\/173.5.1248","volume":"173","author":"WJ Jabs","year":"1996","unstructured":"Jabs WJ, Wagner HJ, Neustock P, Kluter H, Kirchner H (1996) Immunologic properties of Epstein-Barr virus-seronegative adults. J Infect Dis 173:1248\u20131251","journal-title":"J Infect Dis"},{"key":"1325_CR31","doi-asserted-by":"crossref","first-page":"e2499","DOI":"10.1371\/journal.pone.0002499","volume":"3","author":"B Janic","year":"2008","unstructured":"Janic B, Iskander AS, Rad AM, Soltanian-Zadeh H, Arbab AS (2008) Effects of ferumoxides-protamine sulfate labeling on immunomodulatory characteristics of macrophage-like THP-1 cells. PLoS ONE 3:e2499","journal-title":"PLoS ONE"},{"key":"1325_CR32","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/mrm.22290","volume":"63","author":"DA Kedziorek","year":"2010","unstructured":"Kedziorek DA, Muja N, Walczak P, Ruiz-Cabello J, Gilad AA, Jie CC, Bulte JW (2010) Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles. Magn Reson Med 63:1031\u20131043","journal-title":"Magn Reson Med"},{"key":"1325_CR33","doi-asserted-by":"crossref","unstructured":"Kim YM, Reed W, Wu W, Bromberg PA, Graves LM, Samet JM (2006) Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 290:L1028\u2013L1035","DOI":"10.1152\/ajplung.00479.2005"},{"key":"1325_CR34","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.nano.2013.05.002","volume":"9","author":"Y Kim","year":"2013","unstructured":"Kim Y, Kong SD, Chen LH, Pisanic TR 2nd, Jin S, Shubayev VI (2013) In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms. Nanomedicine 9:1057\u20131066","journal-title":"Nanomedicine"},{"key":"1325_CR35","doi-asserted-by":"crossref","unstructured":"Konczol M, Ebeling S, Goldenberg E, Treude F, Gminski R, Giere R, Grobety B, Rothen-Rutishauser B, Merfort I, Mersch-Sundermann V (2011) Cytotoxicity and genotoxicity of size-fractionated iron oxide (magnetite) in A549 human lung epithelial cells: role of ROS, JNK, and NF-kB. Chem Res Toxicol 24:1460\u20131475","DOI":"10.1021\/tx200051s"},{"key":"1325_CR36","first-page":"3503","volume":"7","author":"M Kumar","year":"2012","unstructured":"Kumar M, Singh G, Arora V, Mewar S, Sharma U, Jagannathan NR, Sapra S, Dinda AK, Kharbanda S, Singh H (2012) Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells. Int J Nanomed 7:3503\u20133516","journal-title":"Int J Nanomed"},{"key":"1325_CR37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2217\/nnm.11.148","volume":"7","author":"A Laskar","year":"2012","unstructured":"Laskar A, Ghosh M, Khattak SI, Li W, Yuan XM (2012) Degradation of superparamagnetic iron oxide nanoparticle-induced ferritin by lysosomal cathepsins and related immune response. Nanomedicine 7:705\u2013717","journal-title":"Nanomedicine"},{"key":"1325_CR38","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/smll.200800582","volume":"4","author":"YT Lim","year":"2008","unstructured":"Lim YT, Noh YW, Han JH, Cai QY, Yoon KH, Chung BH (2008) Biocompatible polymer-nanoparticle-based bimodal imaging contrast agents for the labeling and tracking of dendritic cells. Small 4:1640\u20131645","journal-title":"Small"},{"key":"1325_CR39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.toxlet.2011.05.1031","volume":"205","author":"Y Liu","year":"2011","unstructured":"Liu Y, Chen Z, Gu N, Wang J (2011) Effects of DMSA-coated Fe3O4 magnetic nanoparticles on global gene expression of mouse macrophage RAW264.7 cells. Toxicol Lett 205:130\u2013139","journal-title":"Toxicol Lett"},{"key":"1325_CR40","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1016\/j.biomaterials.2010.03.023","volume":"31","author":"O Lunov","year":"2010","unstructured":"Lunov O, Syrovets T, Buchele B, Jiang X, Rocker C, Tron K, Nienhaus GU, Walther P, Mailander V, Landfester K, Simmet T (2010) The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages. Biomaterials 31:5063\u20135071","journal-title":"Biomaterials"},{"key":"1325_CR41","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1182\/blood-2004-07-2782","volume":"105","author":"A Mavropoulos","year":"2005","unstructured":"Mavropoulos A, Sully G, Cope AP, Clark AR (2005) Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Blood 105:282\u2013288","journal-title":"Blood"},{"key":"1325_CR42","doi-asserted-by":"crossref","first-page":"569751","DOI":"10.1155\/2013\/569751","volume":"2013","author":"A Mavropoulos","year":"2013","unstructured":"Mavropoulos A, Rigopoulou EI, Liaskos C, Bogdanos DP, Sakkas LI (2013) The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis. Clin Dev Immunol 2013:569751","journal-title":"Clin Dev Immunol"},{"key":"1325_CR43","doi-asserted-by":"crossref","first-page":"24832","DOI":"10.1074\/jbc.273.38.24832","volume":"273","author":"K Miyazawa","year":"1998","unstructured":"Miyazawa K, Mori A, Miyata H, Akahane M, Ajisawa Y, Okudaira H (1998) Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase. J Biol Chem 273:24832\u201324838","journal-title":"J Biol Chem"},{"key":"1325_CR44","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cyto.2003.08.005","volume":"24","author":"P Myrianthefs","year":"2003","unstructured":"Myrianthefs P, Karatzas S, Venetsanou K, Grouzi E, Evagelopoulou P, Boutzouka E, Fildissis G, Spiliotopoulou I, Baltopoulos G (2003) Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals. Cytokine 24:286\u2013292","journal-title":"Cytokine"},{"key":"1325_CR45","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1172\/JCI32792","volume":"117","author":"R Noubade","year":"2007","unstructured":"Noubade R, Milligan G, Zachary JF, Blankenhorn EP, del Rio R, Rincon M, Teuscher C (2007) Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J Clin Invest 117:3507\u20133518","journal-title":"J Clin Invest"},{"key":"1325_CR46","doi-asserted-by":"crossref","first-page":"265101","DOI":"10.1088\/0957-4484\/19\/26\/265101","volume":"19","author":"RA Pareta","year":"2008","unstructured":"Pareta RA, Taylor E, Webster TJ (2008) Increased osteoblast density in the presence of novel calcium phosphate coated magnetic nanoparticles. Nanotechnology 19:265101","journal-title":"Nanotechnology"},{"key":"1325_CR47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00204-013-1134-1","volume":"88","author":"EJ Park","year":"2014","unstructured":"Park EJ, Umh HN, Kim SW, Cho MH, Kim JH, Kim Y (2014) ERK pathway is activated in bare-FeNPs-induced autophagy. Arch Toxicol 88:323\u2013336","journal-title":"Arch Toxicol"},{"key":"1325_CR48","doi-asserted-by":"crossref","unstructured":"Pasquinelli V, Rovetta AI, Alvarez IB, Jurado JO, Musella RM, Palmero DJ, Malbran A, Samten B, Barnes PF, Garcia VE (2013) Phosphorylation of mitogen-activated protein kinases contributes to interferon \u03b3 production in response to mycobacterium tuberculosis. J Infect Dis 207:340\u2013350","DOI":"10.1093\/infdis\/jis672"},{"key":"1325_CR49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1081\/IMM-120034231","volume":"33","author":"C Patil","year":"2004","unstructured":"Patil C, Zhu X, Rossa C Jr, Kim YJ, Kirkwood KL (2004) p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts. Immunol Invest 33:213\u2013233","journal-title":"Immunol Invest"},{"key":"1325_CR50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/1556-276X-6-383","volume":"6","author":"Y Pineiro-Redondo","year":"2011","unstructured":"Pineiro-Redondo Y, Banobre-Lopez M, Pardinas-Blanco I, Goya G, Lopez-Quintela MA, Rivas J (2011) The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles. Nanoscale Res Lett 6:383","journal-title":"Nanoscale Res Lett"},{"key":"1325_CR51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00232-010-9271-4","volume":"236","author":"S Prijic","year":"2010","unstructured":"Prijic S, Scancar J, Romih R, Cemazar M, Bregar VB, Znidarsic A, Sersa G (2010) Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic field. J Membr Biol 236:167\u2013179","journal-title":"J Membr Biol"},{"key":"1325_CR52","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clim.2004.12.003","volume":"114","author":"NL Rhodus","year":"2005","unstructured":"Rhodus NL, Cheng B, Myers S, Bowles W, Ho V, Ondrey F (2005) A comparison of the pro-inflammatory, NF-kappa B-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol 114:278\u2013283","journal-title":"Clin Immunol"},{"key":"1325_CR53","doi-asserted-by":"crossref","first-page":"19854","DOI":"10.1155\/2007\/19854","volume":"2007","author":"NL Rhodus","year":"2007","unstructured":"Rhodus NL, Cheng B, Ondrey F (2007) Th1\/Th2 cytokine ratio in tissue transudates from patients with oral lichen planus. Mediators Inflamm 2007:19854","journal-title":"Mediators Inflamm"},{"key":"1325_CR54","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/emboj\/17.10.2817","volume":"17","author":"M Rincon","year":"1998","unstructured":"Rincon M, Enslen H, Raingeaud J, Recht M, Zapton T, Su MS, Penix LA, Davis RJ, Flavell RA (1998) Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J 17:2817\u20132829","journal-title":"EMBO J"},{"key":"1325_CR55","first-page":"4447","volume":"7","author":"F Roohi","year":"2012","unstructured":"Roohi F, Lohrke J, Ide A, Schutz G, Dassler K (2012) Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles. Int J Nanomed 7:4447\u20134458","journal-title":"Int J Nanomed"},{"key":"1325_CR56","first-page":"1793","volume":"6","author":"EK Schlachter","year":"2011","unstructured":"Schlachter EK, Widmer HR, Bregy A, Lonnfors-Weitzel T, Vajtai I, Corazza N, Bernau VJ, Weitzel T, Mordasini P, Slotboom J, Herrmann G, Bogni S, Hofmann H, Frenz M, Reinert M (2011) Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study. Int J Nanomed 6:1793\u20131800","journal-title":"Int J Nanomed"},{"key":"1325_CR57","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1148\/radiol.09091134","volume":"255","author":"NJ Serkova","year":"2010","unstructured":"Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM (2010) Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology 255:517\u2013526","journal-title":"Radiology"},{"key":"1325_CR58","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.lfs.2005.04.004","volume":"77","author":"J Shen","year":"2005","unstructured":"Shen J, Sakaida I, Uchida K, Terai S, Okita K (2005) Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated kupffer cells. Life Sci 77:1502\u20131515","journal-title":"Life Sci"},{"key":"1325_CR59","first-page":"2791","volume":"6","author":"CC Shen","year":"2011","unstructured":"Shen CC, Liang HJ, Wang CC, Liao MH, Jan TR (2011a) A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression. Int J Nanomed 6:2791\u20132798","journal-title":"Int J Nanomed"},{"key":"1325_CR60","first-page":"1229","volume":"6","author":"CC Shen","year":"2011","unstructured":"Shen CC, Wang CC, Liao MH, Jan TR (2011b) A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB\/c mice. Int J Nanomed 6:1229\u20131235","journal-title":"Int J Nanomed"},{"key":"1325_CR61","doi-asserted-by":"crossref","first-page":"115103","DOI":"10.1088\/0957-4484\/21\/11\/115103","volume":"21","author":"Y Shi","year":"2010","unstructured":"Shi Y, Zhou L, Wang R, Pang Y, Xiao W, Li H, Su Y, Wang X, Zhu B, Zhu X, Yan D, Gu H (2010) In situ preparation of magnetic nonviral gene vectors and magnetofection in vitro. Nanotechnology 21:115103","journal-title":"Nanotechnology"},{"key":"1325_CR62","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jneuroim.2005.11.011","volume":"173","author":"I Siglienti","year":"2006","unstructured":"Siglienti I, Bendszus M, Kleinschnitz C, Stoll G (2006) Cytokine profile of iron-laden macrophages: implications for cellular magnetic resonance imaging. J Neuroimmunol 173:166\u2013173","journal-title":"J Neuroimmunol"},{"key":"1325_CR63","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/01.ASN.0000048715.12315.FD","volume":"14","author":"C Stambe","year":"2003","unstructured":"Stambe C, Atkins RC, Tesch GH, Kapoun AM, Hill PA, Schreiner GF, Nikolic-Paterson DJ (2003) Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis. J Am Soc Nephrol 14:338\u2013351","journal-title":"J Am Soc Nephrol"},{"key":"1325_CR64","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1021\/la204529u","volume":"28","author":"SL Sun","year":"2012","unstructured":"Sun SL, Lo YL, Chen HY, Wang LF (2012) Hybrid polyethylenimine and polyacrylic acid-bound iron oxide as a magnetoplex for gene delivery. Langmuir 28:3542\u20133552","journal-title":"Langmuir"},{"key":"1325_CR65","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2217\/17435889.4.2.145","volume":"4","author":"EN Taylor","year":"2009","unstructured":"Taylor EN, Webster TJ (2009) The use of superparamagnetic nanoparticles for prosthetic biofilm prevention. Int J Nanomed 4:145\u2013152","journal-title":"Int J Nanomed"},{"key":"1325_CR66","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.biomaterials.2009.09.053","volume":"31","author":"CR Valois","year":"2010","unstructured":"Valois CR, Braz JM, Nunes ES, Vinolo MA, Lima EC, Curi R, Kuebler WM, Azevedo RB (2010) The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a beta2 integrin-dependent pathway. Biomaterials 31:366\u2013374","journal-title":"Biomaterials"},{"key":"1325_CR67","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/jcbfm.2009.192","volume":"30","author":"JS Weinstein","year":"2010","unstructured":"Weinstein JS, Varallyay CG, Dosa E, Gahramanov S, Hamilton B, Rooney WD, Muldoon LL, Neuwelt EA (2010) Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab 30:15\u201335","journal-title":"J Cereb Blood Flow Metab"},{"key":"1325_CR68","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20061704","volume":"404","author":"M Windheim","year":"2007","unstructured":"Windheim M, Lang C, Peggie M, Plater LA, Cohen P (2007) Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J 404:179\u2013190","journal-title":"Biochem J"},{"key":"1325_CR69","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1074-7613(00)80640-8","volume":"9","author":"DD Yang","year":"1998","unstructured":"Yang DD, Conze D, Whitmarsh AJ, Barrett T, Davis RJ, Rincon M, Flavell RA (1998) Differentiation of CD4\u00a0+\u00a0T cells to Th1 cells requires MAP kinase JNK2. Immunity 9:575\u2013585","journal-title":"Immunity"},{"key":"1325_CR70","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11051-009-9589-y","volume":"12","author":"CH Yeh","year":"2010","unstructured":"Yeh CH, Hsiao JK, Wang JL, Sheu F (2010) Immunological impact of magnetic nanoparticles (Ferucarbotran) on murine peritoneal macrophages. J Nanopart Res 12:151\u2013160","journal-title":"J Nanopart Res"},{"key":"1325_CR71","doi-asserted-by":"crossref","unstructured":"Zhang JJ, Xu ZM, Zhang CM, Dai HY, Ji XQ, Wang XF, Li C (2011) Pyrrolidine dithiocarbamate inhibits nuclear factor-kB pathway activation, and regulates adhesion, migration, invasion and apoptosis of endometriotic stromal cells. Mol Hum Reprod 17:175\u2013181","DOI":"10.1093\/molehr\/gaq090"},{"key":"1325_CR72","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tox.2008.02.011","volume":"247","author":"MT Zhu","year":"2008","unstructured":"Zhu MT, Feng WY, Wang B, Wang TC, Gu YQ, Wang M, Wang Y, Ouyang H, Zhao YL, Chai ZF (2008) Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology 247:102\u2013111","journal-title":"Toxicology"},{"key":"1325_CR73","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/smll.201101708","volume":"8","author":"M Zhu","year":"2012","unstructured":"Zhu M, Li Y, Shi J, Feng W, Nie G, Zhao Y (2012) Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation. Small 8:404\u2013412","journal-title":"Small"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1325-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-014-1325-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1325-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T03:21:32Z","timestamp":1717212092000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-014-1325-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,10]]},"references-count":73,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["1325"],"URL":"https:\/\/doi.org\/10.1007\/s00204-014-1325-4","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,10]]}}}