{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:47:21Z","timestamp":1760708841781,"version":"3.41.0"},"reference-count":135,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T00:00:00Z","timestamp":1433030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00204-015-1538-1","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T09:29:20Z","timestamp":1432978160000},"page":"1681-1693","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dual effect of red wine on liver redox status: a concise and mechanistic review"],"prefix":"10.1007","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-6006","authenticated-orcid":false,"given":"Paula","family":"Silva","sequence":"first","affiliation":[]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,5,31]]},"reference":[{"key":"1538_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2014.07.007","volume":"221","author":"A Ahmad","year":"2014","unstructured":"Ahmad A, Ahmad R (2014) Resveratrol mitigate structural changes and hepatic stellate cell activation in N\u2019-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage. Chem Biol Interact 221:1\u201312. doi: 10.1016\/j.cbi.2014.07.007","journal-title":"Chem Biol Interact"},{"key":"1538_CR2","first-page":"597","volume":"4","author":"M Ajakaiye","year":"2011","unstructured":"Ajakaiye M, Jacob A, Wu R, Nicastro JM, Coppa GF, Wang P (2011) Alcohol and hepatocyte-Kupffer cell interaction. Mol Med Rep 4:597\u2013602. doi: 10.3892\/mmr.2011.471","journal-title":"Mol Med Rep"},{"key":"1538_CR3","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1152\/ajpgi.90358.2008","volume":"295","author":"JM Ajmo","year":"2008","unstructured":"Ajmo JM, Liang X, Rogers CQ, Pennock B, You M (2008) Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 295:833\u2013842. doi: 10.1152\/ajpgi.90358.2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1538_CR4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2741\/Albano","volume":"4","author":"E Albano","year":"1999","unstructured":"Albano E, French SW, Ingelman-Sundberg M (1999) Hydroxyethyl radicals in ethanol hepatotoxicity. Front Biosci 4:533\u2013540","journal-title":"Front Biosci"},{"key":"1538_CR5","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1152\/ajpheart.00272.2006","volume":"291","author":"A Andrukhiv","year":"2006","unstructured":"Andrukhiv A, Costa AD, West IC, Garlid KD (2006) Opening mitoKATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol 291:2067\u20132074. doi: 10.1152\/ajpheart.00272.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1538_CR6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.fct.2013.01.029","volume":"61","author":"A Apostolou","year":"2013","unstructured":"Apostolou A, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D (2013) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts. Food Chem Toxicol 61:60\u201368. doi: 10.1016\/j.fct.2013.01.029","journal-title":"Food Chem Toxicol"},{"key":"1538_CR7","first-page":"494","volume":"271","author":"GE Arteel","year":"1996","unstructured":"Arteel GE, Raleigh JA, Bradford BU, Thurman RG (1996) Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells. Am J Physiol 271:494\u2013500","journal-title":"Am J Physiol"},{"key":"1538_CR8","author":"S Bastianetto","year":"2014","unstructured":"Bastianetto S, M\u00e9nard C, Quirion R (2014) Neuroprotective action of resveratrol. Biochim Biophys Acta. doi: 10.1016\/j.bbadis.2014.09.011","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"1538_CR9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/hep.510250214","volume":"25","author":"AP Bautista","year":"1997","unstructured":"Bautista AP (1997) Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. Hepatology 25(2):335\u2013342. doi: 10.1002\/hep.510250214","journal-title":"Hepatology"},{"key":"1538_CR10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hep.510230513","volume":"23","author":"U Becker","year":"1996","unstructured":"Becker U, Deis A, Sorensen TI, Gr\u00f8nbaek M, Borch-Johnsen K, M\u00fcller CF, Schnohr P, Jensen G (1996) Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology 23:1025\u20131029. doi: 10.1002\/hep.510230513","journal-title":"Hepatology"},{"key":"1538_CR11","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1053\/jhep.2002.32101","volume":"35","author":"U Becker","year":"2002","unstructured":"Becker U, Gronbaek M, Johansen D, Sorensen TI (2002) Lower risk for alcohol induced cirrhosis in wine drinkers. Hepatology 35:808\u2013875. doi: 10.1053\/jhep.2002.32101","journal-title":"Hepatology"},{"key":"1538_CR12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1515\/bc.2010.137","volume":"391","author":"JI Beier","year":"2010","unstructured":"Beier JI, McClain CJ (2010) Mechanisms and cell signaling in alcoholic liver disease. Biol Chem 391:1249\u20131264. doi: 10.1515\/BC.2010.137","journal-title":"Biol Chem"},{"issue":"2\u20133","key":"1538_CR13","first-page":"67","volume":"18","author":"AAE Bertelli","year":"1996","unstructured":"Bertelli AAE, Giovannini L, Stradi R, Bertelli A, Tillement JP (1996) Plasma, urine and tissue levels of trans- and cis-resveratrol (3,40,5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int J Tissue React 18(2\u20133):67\u201371","journal-title":"Int J Tissue React"},{"key":"1538_CR14","first-page":"133","volume":"24","author":"A Bertelli","year":"1998","unstructured":"Bertelli A, Bertelli AAE, Gozzini A, Giovannini L (1998) Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 24:133\u2013138","journal-title":"Drugs Exp Clin Res"},{"key":"1538_CR15","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1478-3231.2010.02295.x","volume":"30","author":"A Bishayee","year":"2010","unstructured":"Bishayee A, Darvesh AS, Politis T, McGory R (2010) Resveratrol and liver disease: from bench to bedside and community. Liver Int 30:1103\u20131114. doi: 10.1111\/j.1478-3231.2010.02295.x","journal-title":"Liver Int"},{"key":"1538_CR16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0005-2760(87)90226-8","volume":"918","author":"G-EA Bj\u00f8rneboe","year":"1987","unstructured":"Bj\u00f8rneboe G-EA, Bj\u00f8rneboe A, Hagen BF, M\u00f8rland J, Drevon CA (1987) Reduced hepatic \u03b1-tocopherol content after long-term administration of ethanol to rats. Biochim Biophys Acta 918:236\u2013241","journal-title":"Biochim Biophys Acta"},{"key":"1538_CR17","unstructured":"Blouin J, Peynaud \u00c9 (2012) Connaissance et travail du vin-5e \u00e9dition. Dunod"},{"key":"1538_CR18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1521-6918(03)00034-9","volume":"17","author":"C Bode","year":"2003","unstructured":"Bode C, Bode JC (2003) Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 17:575\u2013592. doi: 10.1016\/S1521-6918(03)00034-9","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"1538_CR19","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/hep.20920","volume":"42","author":"E Bugianesi","year":"2005","unstructured":"Bugianesi E, McCullough AJ, Marchesini G (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42:978\u20131000. doi: 10.1002\/hep.20920","journal-title":"Hepatology"},{"key":"1538_CR20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-230X-8-40","volume":"8","author":"L Bujanda","year":"2008","unstructured":"Bujanda L, Hijona E, Larzabal M, Beraza M, Aldazabal P, Garc\u00eda-Urkia N, Sarasqueta C, Cosme A, Irastorza B, Gonz\u00e1lez A, Arenas JI Jr (2008) Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol 8:40. doi: 10.1186\/1471-230X-8-40","journal-title":"BMC Gastroenterol"},{"key":"1538_CR21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jhep.2012.09.016","volume":"58","author":"JS Byun","year":"2013","unstructured":"Byun JS, Suh YG, Yi HS, Lee YS, Jeong WI (2013) Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. J Hepatol 58:342\u2013349. doi: 10.1016\/j.jhep.2012.09.016","journal-title":"J Hepatol"},{"key":"1538_CR22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0925-4439(02)00174-6","volume":"1637","author":"YJ Cai","year":"2003","unstructured":"Cai YJ, Fang JG, Ma LP, Yang L, Liu ZL (2003) Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochim Biophys Acta 1637:31\u201338. doi: 10.1016\/S0925-4439(02)00174-6","journal-title":"Biochim Biophys Acta"},{"key":"1538_CR23","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0021-9673(99)00595-6","volume":"849","author":"S Carando","year":"1999","unstructured":"Carando S, Teissedre PL, Waffo-Teguo P, Cabanis JC, Deffieux G, Merillon JM (1999) High\u2013performance liquid chromatography coupled with fluorescence detection for the determination of trans\u2013astringin in wine. J Chromatogr A 849:617\u2013620. doi: 10.1016\/S0021-9673(99)00595-6","journal-title":"J Chromatogr A"},{"key":"1538_CR24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","volume":"83","author":"AI Cederbaum","year":"2009","unstructured":"Cederbaum AI, Lu Y, Wu D (2009) Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol 83:519\u2013548. doi: 10.1007\/s00204-009-0432-0","journal-title":"Arch Toxicol"},{"key":"1538_CR25","first-page":"345","volume":"114","author":"S Cenesiz","year":"2007","unstructured":"Cenesiz S, Yarim GF, Karabulut AB, Ara C (2007) Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol. Dtsch Tierarztl Wochenschr 114:345\u2013348","journal-title":"Dtsch Tierarztl Wochenschr"},{"key":"1538_CR26","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/mnfr.201100374","volume":"55","author":"CC Chan","year":"2011","unstructured":"Chan CC, Cheng LY, Lin CL, Huang YH, Lin HC, Lee FY (2011) The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury. Mol Nutr Food Res 55:1841\u20131849. doi: 10.1002\/mnfr.201100374","journal-title":"Mol Nutr Food Res"},{"key":"1538_CR27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/jgh.12366","volume":"29","author":"CC Chan","year":"2014","unstructured":"Chan CC, Lee KC, Huang YH, Chou CK, Lin HC, Lee FY (2014) Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury. J Gastroenterol Hepatol 29:603\u2013613. doi: 10.1111\/jgh.12366","journal-title":"J Gastroenterol Hepatol"},{"key":"1538_CR28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4077\/CJP.2012.BAA012","volume":"55","author":"CC Chang","year":"2012","unstructured":"Chang CC, Chang CY, Huang JP, Hung LM (2012) Effect of resveratrol on oxidative and inflammatory stress in liver and spleen of streptozotocin-induced type 1 diabetic rats. Chin J Physiol 55:192\u2013201. doi: 10.4077\/CJP.2011.BAA012","journal-title":"Chin J Physiol"},{"key":"1538_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jat.1249","volume":"28","author":"E Ch\u00e1vez","year":"2008","unstructured":"Ch\u00e1vez E, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P (2008) Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats. J Appl Toxicol 28:35\u201343. doi: 10.1002\/jat.1249","journal-title":"J Appl Toxicol"},{"key":"1538_CR30","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0016-5085(98)70034-4","volume":"115","author":"A Colell","year":"1998","unstructured":"Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mar\u00ec M, Morales A, Corrales F, Kaplowitz N, Fernandez-Checa JC (1998) Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115:1541\u20131551. doi: 10.1016\/S0016-5085(98)70034-4","journal-title":"Gastroenterology"},{"issue":"5","key":"1538_CR31","first-page":"523","volume":"30","author":"E Conte","year":"2014","unstructured":"Conte E, Fagone E, Fruciano M, Gili E, Iemmolo M, Vancheri C (2014) Anti-inflammatory and antifibrotic effects of resveratrol in the lung. Histol Histopathol 30(5):523\u2013529. doi: 10.14670\/HH-30.523","journal-title":"Histol Histopathol"},{"key":"1538_CR32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200900437","volume":"54","author":"CH Cottart","year":"2010","unstructured":"Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL (2010) Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res 54:7\u201316. doi: 10.1002\/mnfr.200900437","journal-title":"Mol Nutr Food Res"},{"key":"1538_CR33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1440-1746.2006.04582.x","volume":"21","author":"DW Crabb","year":"2006","unstructured":"Crabb DW, Liangpunsakul S (2006) Alcohol and lipid metabolism. J Gastroenterol Hepatol 21:56\u201360. doi: 10.1111\/j.1440-1746.2006.04582.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"3\u20134","key":"1538_CR34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000046892","volume":"10","author":"CC Cunningham","year":"2001","unstructured":"Cunningham CC, Bailey SM (2001) Ethanol consumption and liver mitochondria function. Biol Signals Recept 10(3\u20134):271\u2013282. doi: 10.1159\/000046892","journal-title":"Biol Signals Recept"},{"key":"1538_CR35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1515\/bchm3.1986.367.1.321","volume":"367","author":"M Curzio","year":"1986","unstructured":"Curzio M, Esterbauer H, Di Mauro C, Cecchini G, Dianzani MU (1986) Chemotactic activity of the lipid peroxidation product 4-hydroxynonenal and homologous hydroxyalkenals. Biol Chem Hoppe Seyler 367:321\u2013329","journal-title":"Biol Chem Hoppe Seyler"},{"key":"1538_CR36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/jmf.2007.558","volume":"11","author":"C Dani","year":"2008","unstructured":"Dani C, Oliboni LS, Pasquali MA, Oliveira MR, Umezu FM, Salvador M, Moreira JC, Henriques J\u00c1 (2008) Intake of purple juice as a hepatoprotective agent in Wistar rats. J Med Food 11:127\u2013132. doi: 10.1089\/jmf.2007.558","journal-title":"J Med Food"},{"key":"1538_CR37","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jhep.2012.12.012","volume":"58","author":"M Pascoli Di","year":"2013","unstructured":"Di Pascoli M, Div\u00ed M, Rodr\u00edguez-Vilarrupla A, Rosado E, Gracia-Sancho J, Vilaseca M, Bosch J, Garc\u00eda-Pag\u00e1n JC (2013) Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol 58:904\u2013910. doi: 10.1016\/j.jhep.2012.12.012","journal-title":"J Hepatol"},{"issue":"6","key":"1538_CR38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0741-8329(93)90067-X","volume":"10","author":"JC Fernandez-Checa","year":"1993","unstructured":"Fernandez-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N (1993) Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol 10(6):469\u2013475. doi: 10.1016\/0741-8329(93)90067-X","journal-title":"Alcohol"},{"key":"1538_CR39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1152\/ajpcell.1997.273.1.C7","volume":"273","author":"JC Fernandez-Checa","year":"1997","unstructured":"Fernandez-Checa JC, Kaplowitz N, Garc\u00eda-Ruiz C, Colell A, Miranda M, Mar\u00ed M, Ardite E, Morales A (1997) GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol 273:7\u201317","journal-title":"Am J Physiol"},{"issue":"1\u20132","key":"1538_CR40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/biof.5520080102","volume":"8","author":"JC Fernandez-Checa","year":"1998","unstructured":"Fernandez-Checa JC, Garcia-Ruiz C, Colell A, Morales A, Mari M, Miranda M, Ardite E (1998) Oxidative stress: role of mitochondria and protection by glutathione. BioFactors 8(1\u20132):7\u201311","journal-title":"BioFactors"},{"key":"1538_CR41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.hepres.2004.02.006","volume":"29","author":"SW French","year":"2004","unstructured":"French SW (2004) The role of hypoxia in the pathogenesis of alcoholic liver disease. Hepatol Res 29:69\u201374. doi: 10.1016\/j.hepres.2004.02.006","journal-title":"Hepatol Res"},{"key":"1538_CR42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1074\/jbc.M008791200","volume":"276","author":"A Galli","year":"2001","unstructured":"Galli A, Pinaire J, Fischer M, Dorris R, Crabb DW (2001) The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J Biol Chem 276:68\u201375. doi: 10.1074\/jbc.M008791200","journal-title":"J Biol Chem"},{"key":"1538_CR43","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.3748\/wjg.14.7101","volume":"14","author":"E Gedik","year":"2008","unstructured":"Gedik E, Girgin S, Ozturk H, Obay BD, Ozturk H, Buyukbayram H (2008) Resveratrol attenuates oxidative stress and histological alternations induced by liver ischemia\/reperfusion in rats. World J Gastroenterol 14:7101\u20137106. doi: 10.3748\/wjg.14.7101","journal-title":"World J Gastroenterol"},{"key":"1538_CR44","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1053\/he.2000.5848","volume":"31","author":"S Godichaud","year":"2000","unstructured":"Godichaud S, Krisa S, Couronn\u00e9 B, Dubuisson L, M\u00e9rillon JM, Desmouli\u00e8re A, Rosenbaum J (2000) Deactivation of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol. Hepatology 31:922\u2013931. doi: 10.1053\/he.2000.5848","journal-title":"Hepatology"},{"key":"1538_CR45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fnagi.2014.00095","volume":"6","author":"A Granzotto","year":"2014","unstructured":"Granzotto A, Zatta P (2014) Resveratrol and Alzheimer\u2019s disease: message in a bottle on red wine and cognition. Front Aging Neurosci 6:95. doi: 10.3389\/fnagi.2014.00095","journal-title":"Front Aging Neurosci"},{"key":"1538_CR46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0168-8278(96)80324-2","volume":"25","author":"I Grattagliano","year":"1996","unstructured":"Grattagliano I, Vendemiale G, Sabb\u00e0 G, Buonamico P, Altomare E (1996) Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xanthine oxidase. J Hepatol 25:28\u201336. doi: 10.1016\/S0168-8278(96)80324-2","journal-title":"J Hepatol"},{"key":"1538_CR47","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ifset.2009.07.002","volume":"11","author":"I G\u00fcl\u00e7in","year":"2010","unstructured":"G\u00fcl\u00e7in I (2010) Antioxidant properties of resveratrol: a structure\u2013activity insight. Innov Food Sci Emerg 11:210\u2013218. doi: 10.1016\/j.ifset.2009.07.002","journal-title":"Innov Food Sci Emerg"},{"key":"1538_CR48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/lt.21405","volume":"14","author":"S Hassan-Khabbar","year":"2008","unstructured":"Hassan-Khabbar S, Cottart C, Wendum D, Vibert F, Clot JP, Savouret JF, Conti M, Nivet-Antoine V (2008) Postischemic treatment by trans-resveratrol in rat liver ischemia-reperfusion: a possible strategy in liver surgery. Liver Transpl 14:451\u2013459. doi: 10.1002\/lt.21405","journal-title":"Liver Transpl"},{"key":"1538_CR49","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biochi.2009.12.009","volume":"92","author":"S Hassan-Khabbar","year":"2010","unstructured":"Hassan-Khabbar S, Vamy M, Cottart CH, Wendum D, Vibert F, Savouret JF, Th\u00e9rond P, Clot JP, Waligora AJ, Nivet-Antoine V (2010) Protective effect of post-ischemic treatment with trans-resveratrol on cytokine production and neutrophil recruitment by rat liver. Biochimie 92:405\u2013410. doi: 10.1016\/j.biochi.2009.12.009","journal-title":"Biochimie"},{"key":"1538_CR50","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1464-5491.2006.01864.x","volume":"23","author":"AM Hodge","year":"2006","unstructured":"Hodge AM, English DR, O\u2019Dea K, Giles GG (2006) Alcohol intake, consumption pattern and beverage type, and the risk of Type II diabetes. Diabet Med 23:690\u2013697. doi: 10.1111\/j.1464-5491.2006.01864.x","journal-title":"Diabet Med"},{"key":"1538_CR51","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00003088-198713050-00001","volume":"13","author":"NHG Holford","year":"1987","unstructured":"Holford NHG (1987) Clinical pharmacokinetics of ethanol. Clin Pharmacokinet 13:273\u2013292. doi: 10.2165\/00003088-198713050-00001","journal-title":"Clin Pharmacokinet"},{"key":"1538_CR52","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/ki.2011.347","volume":"81","author":"JH Holthoff","year":"2011","unstructured":"Holthoff JH, Wang Z, Seely KA, Gokden N, Mayeux PR (2011) Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int 81:370\u2013378. doi: 10.1038\/ki.2011.347","journal-title":"Kidney Int"},{"key":"1538_CR53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrn3209","volume":"13","author":"RH Houtkooper","year":"2012","unstructured":"Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13:225\u2013238. doi: 10.1038\/nrm3293","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1538_CR54","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.biocel.2014.06.002","volume":"53","author":"SC Hsu","year":"2014","unstructured":"Hsu SC, Huang SM, Chen A, Sun CY, Lin SH, Chen JS, Liu ST, Hsu YJ (2014) Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3\/c-Jun complex-mediated signaling pathway. Int J Biochem Cell Biol 53:361\u2013371. doi: 10.1016\/j.biocel.2014.06.002","journal-title":"Int J Biochem Cell Biol"},{"key":"1538_CR55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1172\/JCI114999","volume":"87","author":"R Hultcrantz","year":"1991","unstructured":"Hultcrantz R, Bissell DM, Roll FJ (1991) Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol. J Clin Invest 87:45\u201349. doi: 10.1172\/JCI114999","journal-title":"J Clin Invest"},{"key":"1538_CR56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1530-0277.1991.tb00518.x","volume":"15","author":"KG Ishak","year":"1991","unstructured":"Ishak KG, Zimmerman HJ, Ray MB (1991) Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res 15:45\u201366. doi: 10.1111\/j.1530-0277.1991.tb00518.x","journal-title":"Alcohol Clin Exp Res"},{"key":"1538_CR57","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.1073\/pnas.83.20.7923","volume":"83","author":"Y Israel","year":"1986","unstructured":"Israel Y, Hurwitz E, Niemel\u00e4 O, Arnon R (1986) Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc Natl Acad Sci USA 83:7923\u20137927","journal-title":"Proc Natl Acad Sci USA"},{"key":"1538_CR58","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/hep.23739","volume":"52","author":"K Jagavelu","year":"2010","unstructured":"Jagavelu K, Routray C, Shergill U, O\u2019Hara SP, Faubion W, Shah VH (2010) Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver. Hepatology 52:590\u2013601. doi: 10.1002\/hep.23739","journal-title":"Hepatology"},{"key":"1538_CR59","first-page":"1198","volume":"7","author":"A Jamroz","year":"2001","unstructured":"Jamroz A, Beltowski J (2001) Antioxidant capacity of select wines. Med Sci Monit 7:1198\u20131202","journal-title":"Med Sci Monit"},{"issue":"6","key":"1538_CR60","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bcp.2004.04.028","volume":"68","author":"B Jannin","year":"2004","unstructured":"Jannin B, Menzel M, Berlot JP, Delmas D, Lancon A, Latruffe N (2004) Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem Pharmacol 68(6):1113\u20131118. doi: 10.1016\/j.bcp.2004.04.028","journal-title":"Biochem Pharmacol"},{"key":"1538_CR61","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.2337\/db11-1498","volume":"61","author":"BT Jeon","year":"2012","unstructured":"Jeon BT, Jeong EA, Shin HJ, Lee Y, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS (2012) Resveratrol attenuates obesity associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes 61:1444\u20131454. doi: 10.2337\/db11-1498","journal-title":"Diabetes"},{"key":"1538_CR62","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.fct.2013.08.074","volume":"61","author":"I Jur\u00e1nek","year":"2013","unstructured":"Jur\u00e1nek I, Nikitovic D, Kouretas D, Hayes AW, Tsatsakis AM (2013) Biological importance of reactive oxygen species in relation to difficulties of treating pathologies involving oxidative stress by exogenous antioxidants. Food Chem Toxicol 61:240\u2013247. doi: 10.1016\/j.fct.2013.08.074","journal-title":"Food Chem Toxicol"},{"key":"1538_CR63","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/alcalc\/agh256","volume":"41","author":"A Kasdallah-Grissa","year":"2006","unstructured":"Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, Gharbi N, Kamoun A, El-Fazaa S (2006) Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol Alcohol 41:236\u2013239. doi: 10.1093\/alcalc\/agh256","journal-title":"Alcohol Alcohol"},{"key":"1538_CR64","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.lfs.2006.11.044","volume":"80","author":"A Kasdallah-Grissa","year":"2007","unstructured":"Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, El May M, Gharbi N, Kamoun A, El-Faza\u00e2 S (2007) Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci 80:1033\u20131039. doi: 10.1016\/j.lfs.2006.11.044","journal-title":"Life Sci"},{"key":"1538_CR65","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/hep.510270512","volume":"27","author":"N Kawada","year":"1998","unstructured":"Kawada N, Seki S, Inoue M, Kuroki T (1998) Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27:1265\u20131274. doi: 10.1002\/hep.510270512","journal-title":"Hepatology"},{"issue":"5","key":"1538_CR66","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0168-8278(95)80067-0","volume":"23","author":"A Keegan","year":"1995","unstructured":"Keegan A, Martini R, Batey R (1995) Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis. J Hepatol 23(5):591\u2013600. doi: 10.1016\/0168-8278(95)80067-0","journal-title":"J Hepatol"},{"key":"1538_CR67","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1152\/ajpgi.2001.280.5.G1005","volume":"280","author":"H Kono","year":"2001","unstructured":"Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, Mason RP, Thurman RG (2001) Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol 280:1005\u20131012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"1538_CR68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jfoodeng.2005.03.013","volume":"74","author":"Y Kourkoutas","year":"2006","unstructured":"Kourkoutas Y, Kanellaki M, Koutinas AA, Tzia C (2006) Effect of storage of immobilized cells at ambient temperature on volatile by-products during wine-making. J Food Eng 74(2):217\u2013223. doi: 10.1016\/j.jfoodeng.2005.03.013","journal-title":"J Food Eng"},{"key":"1538_CR69","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"M Lagouge","year":"2006","unstructured":"Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109\u20131122. doi: 10.1016\/j.cell.2006.11.013","journal-title":"Cell"},{"key":"1538_CR70","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1021\/jf010794g","volume":"50","author":"N Landrault","year":"2002","unstructured":"Landrault N, Larronde F, Delaunay JC, Castagnino C, Vercauteren J, Merillon JM, Gasc F, Cros G, Teissedre PL (2002) Levels of stilbene oligomers and astilbin in French wines and grapes during noble rot development. J Agric Food Chem 50:2046\u20132052. doi: 10.1021\/jf010794g","journal-title":"J Agric Food Chem"},{"key":"1538_CR71","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/j.1530-0277.1995.tb00969.x","volume":"19","author":"WE Lands","year":"1995","unstructured":"Lands WE (1995) Cellular signals in alcohol-induced liver injury: a review. Alcohol Clin Exp Res 19:928\u2013938. doi: 10.1111\/j.1530-0277.1995.tb00969.x","journal-title":"Alcohol Clin Exp Res"},{"key":"1538_CR72","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-0187-9","volume-title":"Fermented beverage production","author":"AG Lea","year":"2003","unstructured":"Lea AG, Piggott JR, Piggott JR (2003) Fermented beverage production. Springer, United States"},{"key":"1538_CR73","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s12272-010-0616-4","volume":"33","author":"ES Lee","year":"2010","unstructured":"Lee ES, Shin MO, Yoon S, Moon JO (2010) Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Arch Pharm Res 33:925\u2013932. doi: 10.1007\/s12272-010-0616-4","journal-title":"Arch Pharm Res"},{"key":"1538_CR74","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.fct.2013.08.036","volume":"63","author":"L Li","year":"2014","unstructured":"Li L, Hai J, Li Z, Zhang Y, Peng H, Li K, Weng X (2014) Resveratrol modulates autophagy and NF-\u03baB activity in a murine model for treating non-alcoholic fatty liver disease. Food Chem Toxicol 63:166\u2013173. doi: 10.1016\/j.fct.2013.08.036","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"1538_CR75","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0016-5085(94)90772-2","volume":"106","author":"CS Lieber","year":"1994","unstructured":"Lieber CS (1994) Alcohol and the liver: 1994 update. Gastroenterology 106(4):1085\u20131105","journal-title":"Gastroenterology"},{"key":"1538_CR76","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0009-8981(96)06434-0","volume":"257","author":"CS Lieber","year":"1997","unstructured":"Lieber CS (1997) Ethanol metabolism, cirrhosis and alcoholism. Clin Chim Acta 257:59\u201384. doi: 10.1016\/S0009-8981(96)06434-0","journal-title":"Clin Chim Acta"},{"key":"1538_CR77","first-page":"991","volume":"23","author":"CS Lieber","year":"1999","unstructured":"Lieber CS (1999) Microsomal ethanol-oxidizing system (MEOS): the first 30\u00a0years (1968\u20131998)\u2014a review. Alcohol Clin Exp Res 23:991\u20131007. doi: 10.1111\/j.1530-0277.1999.tb04217.x","journal-title":"Alcohol Clin Exp Res"},{"key":"1538_CR78","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2008.03.005","volume":"370","author":"CS Lieber","year":"2008","unstructured":"Lieber CS, Leo MA, Wang X, Decarli LM (2008) Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats. Biochem Biophys Res Commun 370:44\u201348. doi: 10.1016\/j.bbrc.2008.03.005","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1538_CR79","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/acer.12311","volume":"38","author":"L Liu","year":"2014","unstructured":"Liu L, Fan Z, Tang Y, Ke Z (2014) The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity. Alcohol Clin Exp Res 38(3):683\u2013693. doi: 10.1111\/acer.12311","journal-title":"Alcohol Clin Exp Res"},{"key":"1538_CR80","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10408690390826509","volume":"43","author":"M L\u00f3pez-V\u00e9lez","year":"2003","unstructured":"L\u00f3pez-V\u00e9lez M, Mart\u00ednez-Mart\u00ednez F, Del Valle-Ribes C (2003) The study of phenolic compounds as natural antioxidants in wine. Crit Rev Food Sci Nutr 43:233\u2013244. doi: 10.1080\/10408690390826509","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1538_CR81","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/hep.22222","volume":"47","author":"Y Lu","year":"2008","unstructured":"Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI (2008) Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47:1483\u20131494. doi: 10.1002\/hep.22222","journal-title":"Hepatology"},{"issue":"1","key":"1538_CR82","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1089-3261(05)70099-4","volume":"4","author":"WC Maddrey","year":"2000","unstructured":"Maddrey WC (2000) Alcoholic-induced liver disease. Clin Liver Dis 4(1):115\u2013131","journal-title":"Clin Liver Dis"},{"key":"1538_CR83","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1083\/jcb.200105057","volume":"155","author":"M Madesh","year":"2001","unstructured":"Madesh M, Hajnoczky G (2001) VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 155:1003\u20131015. doi: 10.1083\/jcb.200105057","journal-title":"J Cell Biol"},{"key":"1538_CR84","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","volume":"134","author":"H Malhi","year":"2008","unstructured":"Malhi H, Gores GJ (2008) Cellular and molecular mechanisms of liver injury. Gastroenterology 134:1641\u20131654. doi: 10.1053\/j.gastro.2008.03.002","journal-title":"Gastroenterology"},{"issue":"1","key":"1538_CR85","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/jpet.102.033340","volume":"302","author":"JF Marier","year":"2002","unstructured":"Marier JF, Vachon P, Gritsas A, Zhang J, Moreau JP, Ducharme MP (2002) Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked\u2013rat model. J Pharmacol Exp Ther 302(1):369\u2013373. doi: 10.1124\/jpet.102.033340","journal-title":"J Pharmacol Exp Ther"},{"key":"1538_CR86","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.3748\/wjg.15.2609","volume":"15","author":"BL McVicker","year":"2009","unstructured":"McVicker BL, Tuma PL, Kharbanda KK, Lee SM, Tuma DJ (2009) Relationship between oxidative stress and hepatic glutathione levels in ethanol\u2013mediated apoptosis of polarized hepatic cells. World J Gastroenterol 15:2609\u20132616. doi: 10.3748\/wjg.15.2609","journal-title":"World J Gastroenterol"},{"key":"1538_CR87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mam.2007.10.001","volume":"29","author":"T Mello","year":"2008","unstructured":"Mello T, Ceni E, Surrenti C, Galli A (2008) Alcohol induced hepatic fibrosis: role of acetaldehyde. Mol Aspects Med 29:17\u201321. doi: 10.1016\/j.mam.2007.10.001","journal-title":"Mol Aspects Med"},{"key":"1538_CR88","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/abbi.1995.1203","volume":"318","author":"L Mira","year":"1995","unstructured":"Mira L, Maia L, Barreira L, Manso CF (1995) Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism. Arch Biochem Biophys 318:53\u201358. doi: 10.1006\/abbi.1995.1203","journal-title":"Arch Biochem Biophys"},{"key":"1538_CR89","doi-asserted-by":"crossref","first-page":"10567","DOI":"10.1021\/jf503310c","volume":"62","author":"I Mu\u00f1oz-Gonz\u00e1lez","year":"2014","unstructured":"Mu\u00f1oz-Gonz\u00e1lez I, Espinosa-Martos I, Rodr\u00edguez JM, Jim\u00e9nez-Gir\u00f3n A, Mart\u00edn-\u00c1lvarez PJ, Bartolom\u00e9 B, Moreno-Arribas MV (2014) Moderate consumption of red wine can modulate human intestinal inflammatory response. J Agric Food Chem 62:10567\u201310575. doi: 10.1021\/jf503310c","journal-title":"J Agric Food Chem"},{"issue":"4","key":"1538_CR90","first-page":"325","volume":"21","author":"AA Nanji","year":"1997","unstructured":"Nanji AA, Hiller-Sturmhofel S (1997) Apoptosis and necrosis: two types of cell death in liver disease. Alcohol Health Res World 21(4):325\u2013330","journal-title":"Alcohol Health Res World"},{"key":"1538_CR91","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0168-8278(00)00089-1","volume":"34","author":"S Natori","year":"2001","unstructured":"Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ (2001) Hepatocyte apoptosis is a pathological feature of human alcoholic hepatitis. J Hepatol 34:248\u2013253. doi: 10.1016\/S0168-8278(00)00089-1","journal-title":"J Hepatol"},{"key":"1538_CR92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003088-200342010-00001","volume":"42","author":"A Norberg","year":"2003","unstructured":"Norberg A, Jones AW, Hahn RG, Gabrielsson JL (2003) Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. Clin Pharmacokinet 42:1\u201331. doi: 10.2165\/00003088-200342010-00001","journal-title":"Clin Pharmacokinet"},{"key":"1538_CR93","author":"E Okay","year":"2014","unstructured":"Okay E, Simsek T, Subasi C, Gunes A, Duruksu G, Gurbuz Y, Gacar G, Karaoz E (2014) Cross effects of resveratrol and mesenchymal stem cells on liver regeneration and homing in partially hepatectomized rats. Stem Cell Rev Rep. doi: 10.1007\/s12015-014-9572-6","journal-title":"Stem Cell Rev Rep"},{"key":"1538_CR94","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1042\/bj1310555","volume":"131","author":"N Oshino","year":"1973","unstructured":"Oshino N, Oshino R, Chance B (1973) The characteristics of the peroxidatic reaction in ethanol oxidation. Biochem J 131:555\u2013567","journal-title":"Biochem J"},{"key":"1538_CR95","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","volume":"37","author":"YH Paik","year":"2003","unstructured":"Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA (2003) Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37:1043\u20131055. doi: 10.1053\/jhep.2003.50182","journal-title":"Hepatology"},{"key":"1538_CR96","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI37409","volume":"119","author":"Z Peng","year":"2009","unstructured":"Peng Z, Borea PA, Varani K, Wilder T, Yee H, Chiriboga L, Blackburn MR, Azzena G, Resta G, Cronstein BN (2009) Adenosine signaling contributes to ethanol-induced fatty liver in mice. J Clin Invest 119:582\u2013594. doi: 10.1172\/JCI37409","journal-title":"J Clin Invest"},{"key":"1538_CR97","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jhep.2005.03.004","volume":"42","author":"D Pessayre","year":"2005","unstructured":"Pessayre D, Fromenty B (2005) NASH a mitochondrial disease. J Hepatol 42:928\u2013940. doi: 10.1016\/j.jhep.2005.03.004","journal-title":"J Hepatol"},{"key":"1538_CR98","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2337\/db12-0975","volume":"4","author":"MM Poulsen","year":"2013","unstructured":"Poulsen MM, Vestergaard PF, Clasen BF, Radko Y, Christensen LP, St\u00f8dkilde-J\u00f8rgensen H, M\u00f8ller N, Jessen N, Pedersen SB, J\u00f8rgensen JO (2013) High-Dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 4:1186\u20131195. doi: 10.2337\/db12-0975","journal-title":"Diabetes"},{"key":"1538_CR99","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0026-895X(25)09069-8","volume":"49","author":"DNR Rao","year":"1996","unstructured":"Rao DNR, Yang MX, Lasker JM, Cederbaum AI (1996) 1-hydroxyethyl radical formation during NADPH- and NADH-dependent oxidation of ethanol by human liver microsomes. Mol Pharmacol 49:814\u2013821","journal-title":"Mol Pharmacol"},{"key":"1538_CR100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/abbi.1997.0387","volume":"348","author":"LA Reinke","year":"1997","unstructured":"Reinke LA, Moore DR, McCay PB (1997) Mechanisms for metabolism of ethanol to 1-hydroxyethyl radicals in rat liver microsomes. Arch Biochem Biophys 348:9\u201314. doi: 10.1006\/abbi.1997.0387","journal-title":"Arch Biochem Biophys"},{"key":"1538_CR101","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","volume":"339","author":"S Renaud","year":"1992","unstructured":"Renaud S, de Lorgeril M (1992) Wine, alcohol, platelets, and the French Paradox for coronary heart disease. Lancet 339:1523\u20131526. doi: 10.1016\/0140-6736(92)91277-F","journal-title":"Lancet"},{"key":"1538_CR102","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/jat.1260","volume":"28","author":"H Rivera","year":"2008","unstructured":"Rivera H, Shibayama M, Tsutsumi V, Perez-Alvarez V, Muriel P (2008) Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CCl4 in the rat. J Appl Toxicol 28:147\u2013155. doi: 10.1002\/jat.1260","journal-title":"J Appl Toxicol"},{"key":"1538_CR103","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1021\/jf9507654","volume":"44","author":"A Romero-P\u00e9rez","year":"1996","unstructured":"Romero-P\u00e9rez A, Lamuela-Ravent\u00f3s RM, Waterhouse AL, de la Torre-Boronat MC (1996) Levels of cis\u2013and trans\u2013resveratrol and their glucosides in white and ros\u00e9 Vitis vinifera wines from Spain. J Agric Food Chem 44:2124\u20132128","journal-title":"J Agric Food Chem"},{"key":"1538_CR104","first-page":"211","volume-title":"Cytochromes P450: metabolic and toxicological aspects","author":"MJJ Ronis","year":"1996","unstructured":"Ronis MJJ, Lindros KO, Ingelman-Sundberg M (1996) The CYP2E family. In: Ioannides C (ed) Cytochromes P450: metabolic and toxicological aspects. CRC Press, Boca Raton, pp 211\u2013239"},{"issue":"2","key":"1538_CR105","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.toxlet.2014.01.042","volume":"230","author":"D Sahpazidou","year":"2014","unstructured":"Sahpazidou D, Geromichalos GD, Stagos D, Apostolou A, Haroutounian SA, Tsatsakis AM, Tzanakakis GN, Hayes AW, Kouretas D (2014) Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells. Toxicol Lett 230(2):218\u2013224. doi: 10.1016\/j.toxlet.2014.01.042","journal-title":"Toxicol Lett"},{"key":"1538_CR106","doi-asserted-by":"crossref","unstructured":"Saldanha JF, Leal Vde O, Stenvinkel P, Carraro-Eduardo JC, Mafra D (2013) Resveratrol: why is it a promising therapy for chronic kidney disease patients? Oxid Med Cell Longev Article ID 963217. http:\/\/dx.doi.org\/10.1155\/2013\/963217","DOI":"10.1155\/2013\/963217"},{"key":"1538_CR107","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1247\/csf.28.105","volume":"28","author":"M Sato","year":"2003","unstructured":"Sato M, Suzuki S, Senoo H (2003) Hepatic stellate cells: unique characteristics in cell biology and phenotype. Cell Struct Funct 28:105\u2013112. doi: 10.1247\/csf.28.105","journal-title":"Cell Struct Funct"},{"key":"1538_CR108","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","volume":"13","author":"E Seki","year":"2007","unstructured":"Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF (2007) TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 13:1324\u20131332. doi: 10.1038\/nm1663","journal-title":"Nat Med"},{"key":"1538_CR109","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00795-003-0230-3","volume":"37","author":"H Senoo","year":"2004","unstructured":"Senoo H (2004) Structure and function of hepatic stellate cells. Med Electron Microsc 37:3\u201315. doi: 10.1007\/s00795-003-0230-3","journal-title":"Med Electron Microsc"},{"key":"1538_CR110","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.1074\/jbc.M410310200","volume":"280","author":"JM Shattemberg","year":"2005","unstructured":"Shattemberg JM, Wang Y, Singh R, Rigoli RM, Czaja MJ (2005) Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signalling. J Biol Chem 280:9887\u20139894. doi: 10.1074\/jbc.M410310200","journal-title":"J Biol Chem"},{"key":"1538_CR111","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0891-5849(90)90044-J","volume":"9","author":"S Shaw","year":"1990","unstructured":"Shaw S, Jayatilleke E (1990a) Ethanol-induced iron mobilization: role of acetaldehyde-aldehyde oxidase generated superoxide. Free Radic Biol Med 9:11\u201315","journal-title":"Free Radic Biol Med"},{"key":"1538_CR112","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1042\/bj2680579","volume":"J268","author":"S Shaw","year":"1990","unstructured":"Shaw S, Jayatilleke E (1990b) The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat. Biochem J268:579\u2013583","journal-title":"Biochem"},{"key":"1538_CR113","first-page":"1","volume-title":"Alcohol toxicity and free radical mechanisms, advances in biosciences","author":"TF Slater","year":"1988","unstructured":"Slater TF (1988) Free radicals mechanisms in tissue injury with special reference to the cytotoxic effects of ethanol and related alcohols. In: Nordmann R, Ribiere C, Rouach H (eds) Alcohol toxicity and free radical mechanisms, advances in biosciences, vol 71. Pergamon Press, Oxford, pp 1\u20139"},{"key":"1538_CR114","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/09571269508718028","volume":"6","author":"GJ Soleas","year":"1995","unstructured":"Soleas GJ, Goldberg DM, Karumanchiri A, Diamandis EP, Ng E (1995) Influences of viticultural and enological factors on changes in cis\u2013 and trans\u2013resveratrol in commercial wines. J Wine Res 6:107\u2013121. doi: 10.1080\/09571269508718028","journal-title":"J Wine Res"},{"key":"1538_CR115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-008-9781-x","volume":"315","author":"IC Souza","year":"2008","unstructured":"Souza IC, Martins LA, Coelho BP, Grivicich I, Guaragna RM, Gottfried C, Borojevic R, Guma FC (2008) Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells. Mol Cell Biochem 315:1\u20137. doi: 10.1007\/s11010-008-9781-x","journal-title":"Mol Cell Biochem"},{"key":"1538_CR116","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S1471-4914(01)02096-2","volume":"7","author":"S Stewart","year":"2001","unstructured":"Stewart S, Jones D, Day CP (2001) Alcoholic liver disease: new insights into mechanisms and preventative strategies. Trends Mol Med 7:408\u2013413. doi: 10.1016\/S1471-4914(01)02096-2","journal-title":"Trends Mol Med"},{"key":"1538_CR117","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1053\/he.2000.5634","volume":"31","author":"GL Su","year":"2000","unstructured":"Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, Alarcon WH, Remick DG, Wang SC (2000) Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31:932\u2013936. doi: 10.1053\/he.2000.5634","journal-title":"Hepatology"},{"key":"1538_CR118","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3748\/wjg.v16.i11.1321","volume":"16","author":"G Szabo","year":"2010","unstructured":"Szabo G, Bala S (2010) Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 16:1321\u20131329","journal-title":"World J Gastroenterol"},{"key":"1538_CR119","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2010.05844.x","volume":"1215","author":"T Szkudelski","year":"2011","unstructured":"Szkudelski T, Szkudelska K (2011) Anti-diabetic effects of resveratrol. Ann N Y Acad Sci 1215:34\u201339. doi: 10.1111\/j.1749-6632.2010.05844.x","journal-title":"Ann N Y Acad Sci"},{"key":"1538_CR120","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1530-0277.2000.tb04629.x","volume":"24","author":"H Tamai","year":"2000","unstructured":"Tamai H, Kato S, Horie Y, Ohki E, Yokoyama H, Ishii H (2000) Effect of acute ethanol administration on the intestinal absorption of endotoxin in rats. Alcohol Clin Exp Res 24:390\u2013394. doi: 10.1111\/j.1530-0277.2000.tb04629.x","journal-title":"Alcohol Clin Exp Res"},{"key":"1538_CR121","author":"P Toth","year":"2015","unstructured":"Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, Wren JD, Koller A, Sonntag WE, Csiszar A, Ungvari Z (2015) Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. doi: 10.1111\/acel.12315","journal-title":"Aging Cell"},{"issue":"2","key":"1538_CR122","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/bj1880549","volume":"188","author":"J Vina","year":"1980","unstructured":"Vina J, Estrela JM, Guerri C, Romero FJ (1980) Effect of ethanol on glutathione concentration in isolated hepatocytes. Biochem J 188(2):549\u2013552","journal-title":"Biochem J"},{"key":"1538_CR123","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.2010.05842.x","volume":"1215","author":"T Walle","year":"2011","unstructured":"Walle T (2011) Bioavailability of resveratrol. Ann N Y Acad Sci 1215:9\u201315. doi: 10.1111\/j.1749-6632.2010.05842.x","journal-title":"Ann N Y Acad Sci"},{"key":"1538_CR124","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","volume":"32","author":"T Walle","year":"2004","unstructured":"Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK (2004) High absorption but very low bioavailability of oral resveratrol metabolism in humans. Drug Metab Dispos 32:1377\u20131382. doi: 10.1124\/dmd.104.000885","journal-title":"Drug Metab Dispos"},{"key":"1538_CR125","doi-asserted-by":"crossref","first-page":"e996","DOI":"10.1038\/cddis.2013.499","volume":"5","author":"K Wang","year":"2014","unstructured":"Wang K (2014) Molecular mechanisms of hepatic apoptosis. Cell Death Dis 5:e996. doi: 10.1038\/cddis.2013.499","journal-title":"Cell Death Dis"},{"issue":"50","key":"1538_CR126","doi-asserted-by":"crossref","first-page":"49920","DOI":"10.1074\/jbc.M310156200","volume":"278","author":"GL Wheeler","year":"2003","unstructured":"Wheeler GL, Trotter EW, Dawes IW, Grant CM (2003) Coupling of the transcriptional regulation of glutathione biosynthesis to the availability of glutathione and methionine via the Met4 and Yap1 transcription factors. J Biol Chem 278(50):49920\u201349928. doi: 10.1074\/jbc.M310156200","journal-title":"J Biol Chem"},{"key":"1538_CR127","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1021\/jf050093+","volume":"53","author":"H Yang","year":"2005","unstructured":"Yang H, Lee MK, Kim YC (2005a) Protective activities of stilbene glycosides from Acer mono leaves against H2O2-induced oxidative damage in primary cultured rat hepatocytes. J Agric Food Chem 53:4182\u20134186. doi: 10.1021\/jf050093+","journal-title":"J Agric Food Chem"},{"key":"1538_CR128","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/np0497907","volume":"68","author":"H Yang","year":"2005","unstructured":"Yang H, Sung SH, Kim YC (2005b) Two new hepatoprotective stilbene glycosides from Acer mono leaves. J Nat Prod 68:101\u2013103. doi: 10.1021\/np0497907","journal-title":"J Nat Prod"},{"key":"1538_CR129","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cmet.2012.09.015","volume":"16","author":"J Yoshino","year":"2012","unstructured":"Yoshino J, Conte C, Fontana L, Mittendorfer Imai S, Schechtman KB, Gu C, Kunz I, Rossi Fanelli F, Patterson BW, Klein S (2012) Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance. Cell Metab 16:658\u2013664. doi: 10.1016\/j.cmet.2012.09.015","journal-title":"Cell Metab"},{"key":"1538_CR130","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","volume":"277","author":"M You","year":"2002","unstructured":"You M, Fischer M, Deeg MA, Crabb DW (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element binding protein (SREBP). J Biol Chem 277:29342\u201329347","journal-title":"J Biol Chem"},{"key":"1538_CR131","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","volume":"127","author":"M You","year":"2004","unstructured":"You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW (2004) The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127:1798\u20131808. doi: 10.1053\/j.gastro.2004.09.049","journal-title":"Gastroenterology"},{"key":"1538_CR132","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/hep.20821","volume":"42","author":"M You","year":"2005","unstructured":"You M, Considine RV, Leone TC, Kelly DP, Crabb DW (2005) Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42:568\u2013577. doi: 10.1002\/hep.20821","journal-title":"Hepatology"},{"key":"1538_CR133","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1152\/ajpgi.00575.2007","volume":"294","author":"M You","year":"2008","unstructured":"You M, Liang X, Ajmo JM, Ness GC (2008) Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am J Physiol Gastrointest Liver Physiol 294:892\u2013898. doi: 10.1152\/ajpgi.00575.2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1538_CR134","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/jcb.23431","volume":"113","author":"W Yu","year":"2012","unstructured":"Yu W, Fu YC, Wang W (2012) Cellular and molecular effects of resveratrol in health and disease. J Cell Biochem 113:752\u2013759. doi: 10.1002\/jcb.23431","journal-title":"J Cell Biochem"},{"key":"1538_CR135","doi-asserted-by":"crossref","first-page":"34682","DOI":"10.1074\/jbc.M402999200","volume":"279","author":"K Zhao","year":"2004","unstructured":"Zhao K, Zhao GM, Wu D, Soong Y, Birk AV, Schiller PW, Szeto HH (2004) Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem 279:34682\u201334690. doi: 10.1074\/jbc.M402999200","journal-title":"J Biol Chem"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1538-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-015-1538-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1538-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T05:04:44Z","timestamp":1748408684000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-015-1538-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,31]]},"references-count":135,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["1538"],"URL":"https:\/\/doi.org\/10.1007\/s00204-015-1538-1","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"type":"print","value":"0340-5761"},{"type":"electronic","value":"1432-0738"}],"subject":[],"published":{"date-parts":[[2015,5,31]]}}}