{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:17:52Z","timestamp":1764782272325,"version":"3.37.3"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-029584"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029584"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCIBIO - Unidade de Ci\u00eancias Biomoleculares Aplicadas","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}]},{"name":"COMPETE 2020 \u2013 Operational Programme for Competitiveness and Internationalisation","award":["POCI-01-0145-FEDER-029584"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029584"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00204-021-02990-9","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T04:09:55Z","timestamp":1612843795000},"page":"1443-1462","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["From street to lab: in vitro hepatotoxicity of buphedrone, butylone and 3,4-DMMC"],"prefix":"10.1007","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-6903","authenticated-orcid":false,"given":"Rita","family":"Roque Bravo","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-5285","authenticated-orcid":false,"given":"Helena","family":"Carmo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6162-2426","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Valente","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-0897","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-3494","authenticated-orcid":false,"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-503X","authenticated-orcid":false,"given":"Maria de Lourdes","family":"Bastos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7331-9157","authenticated-orcid":false,"given":"Diana","family":"Dias da Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"issue":"1","key":"2990_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/dta.1924","volume":"8","author":"P Adamowicz","year":"2016","unstructured":"Adamowicz P, Gieron J, Gil D, Lechowicz W, Skulska A, Tokarczyk B (2016) The prevalence of new psychoactive substances in biological material\u2014a three-year review of casework in Poland. Drug Test Anal 8(1):63\u201370. https:\/\/doi.org\/10.1002\/dta.1924","journal-title":"Drug Test Anal"},{"issue":"1","key":"2990_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1124\/dmd.105.006759","volume":"34","author":"C Aninat","year":"2006","unstructured":"Aninat C, Piton A, Glaise D et al (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34(1):75\u201383. https:\/\/doi.org\/10.1124\/dmd.105.006759","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"2990_CR3","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00204-014-1278-7","volume":"89","author":"AM Araujo","year":"2015","unstructured":"Araujo AM, Valente MJ, Carvalho M et al (2015) Raising awareness of new psychoactive substances: chemical analysis and in vitro toxicity screening of \u201clegal high\u201d packages containing synthetic cathinones. Arch Toxicol 89(5):757\u2013771. https:\/\/doi.org\/10.1007\/s00204-014-1278-7","journal-title":"Arch Toxicol"},{"issue":"1","key":"2990_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/jat.3153","volume":"36","author":"MD Arbo","year":"2016","unstructured":"Arbo MD, Silva R, Barbosa DJ et al (2016) In vitro neurotoxicity evaluation of piperazine designer drugs in differentiated human neuroblastoma SH-SY5Y cells. J Appl Toxicol 36(1):121\u2013130. https:\/\/doi.org\/10.1002\/jat.3153","journal-title":"J Appl Toxicol"},{"issue":"1","key":"2990_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.pharmthera.2012.01.001","volume":"134","author":"A Astashkina","year":"2012","unstructured":"Astashkina A, Mann B, Grainger DW (2012) A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. Pharmacol Ther 134(1):82\u2013106. https:\/\/doi.org\/10.1016\/j.pharmthera.2012.01.001","journal-title":"Pharmacol Ther"},{"issue":"1","key":"2990_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/toxsci\/kfv041","volume":"145","author":"P Bachour-El Azzi","year":"2015","unstructured":"Bachour-El Azzi P, Sharanek A, Burban A et al (2015) Comparative localization and functional activity of the main hepatobiliary transporters in HepaRG cells and primary human hepatocytes. Toxicol Sci 145(1):157\u2013168. https:\/\/doi.org\/10.1093\/toxsci\/kfv041","journal-title":"Toxicol Sci"},{"issue":"3","key":"2990_CR7","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1478-3231.1999.tb00041.x","volume":"19","author":"G Beitia","year":"1999","unstructured":"Beitia G, Cobreros A, Sainz L, Cenarruzabeitia E (1999) 3,4-Methylenedioxymethamphetamine (ecstasy)-induced hepatotoxicity: effect on cytosolic calcium signals in isolated hepatocytes. Liver 19(3):234\u2013241","journal-title":"Liver"},{"issue":"3 Pt 1","key":"2990_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/BF02628465","volume":"25","author":"ME Bouma","year":"1989","unstructured":"Bouma ME, Rogier E, Verthier N, Labarre C, Feldmann G (1989) Further cellular investigation of the human hepatoblastoma-derived cell line HepG2: morphology and immunocytochemical studies of hepatic-secreted proteins. Vitro Cell Dev Biol 25(3 Pt 1):267\u2013275","journal-title":"Vitro Cell Dev Biol"},{"key":"2990_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-4985-6","author":"DM Calinski","year":"2018","unstructured":"Calinski DM, Kisor DF, Sprague JE (2018) A review of the influence of functional group modifications to the core scaffold of synthetic cathinones on drug pharmacokinetics. Psychopharmacology 236(3):881\u2013890. https:\/\/doi.org\/10.1007\/s00213-018-4985-6","journal-title":"Psychopharmacology"},{"key":"2990_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4137\/JCD.S39824","volume":"9","author":"L Cao","year":"2016","unstructured":"Cao L, Quan XB, Zeng WJ, Yang XO, Wang MJ (2016) Mechanism of hepatocyte apoptosis. J Cell Death 9:19\u201329. https:\/\/doi.org\/10.4137\/JCD.S39824","journal-title":"J Cell Death"},{"issue":"6","key":"2990_CR11","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1021\/tx9501750","volume":"9","author":"F Carvalho","year":"1996","unstructured":"Carvalho F, Remiao F, Amado F, Domingues P, Correia AJ, Bastos ML (1996) d-Amphetamine interaction with glutathione in freshly isolated rat hepatocytes. Chem Res Toxicol 9(6):1031\u20131036. https:\/\/doi.org\/10.1021\/tx9501750","journal-title":"Chem Res Toxicol"},{"issue":"12","key":"2990_CR12","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s002040000200","volume":"74","author":"M Carvalho","year":"2001","unstructured":"Carvalho M, Carvalho F, Bastos ML (2001) Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes. Arch Toxicol 74(12):789\u2013793","journal-title":"Arch Toxicol"},{"issue":"2\u20133","key":"2990_CR13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.tox.2004.03.016","volume":"200","author":"M Carvalho","year":"2004","unstructured":"Carvalho M, Remiao F, Milhazes N et al (2004) The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200(2\u20133):193\u2013203. https:\/\/doi.org\/10.1016\/j.tox.2004.03.016","journal-title":"Toxicology"},{"issue":"8","key":"2990_CR14","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00204-012-0815-5","volume":"86","author":"M Carvalho","year":"2012","unstructured":"Carvalho M, Carmo H, Costa VM et al (2012) Toxicity of amphetamines: an update. Arch Toxicol 86(8):1167\u20131231. https:\/\/doi.org\/10.1007\/s00204-012-0815-5","journal-title":"Arch Toxicol"},{"issue":"5","key":"2990_CR15","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.phrs.2011.08.002","volume":"64","author":"D Cerretani","year":"2011","unstructured":"Cerretani D, Bello S, Cantatore S et al (2011) Acute administration of 3,4-methylenedioxymethamphetamine (MDMA) induces oxidative stress, lipoperoxidation and TNFalpha-mediated apoptosis in rat liver. Pharmacol Res 64(5):517\u2013527. https:\/\/doi.org\/10.1016\/j.phrs.2011.08.002","journal-title":"Pharmacol Res"},{"key":"2990_CR16","doi-asserted-by":"publisher","first-page":"424285","DOI":"10.1155\/2012\/424285","volume":"2012","author":"P Chandramani Shivalingappa","year":"2012","unstructured":"Chandramani Shivalingappa P, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A (2012) N-acetyl cysteine protects against methamphetamine-induced dopaminergic neurodegeneration via modulation of redox status and autophagy in dopaminergic cells. Parkinsons Dis 2012:424285. https:\/\/doi.org\/10.1155\/2012\/424285","journal-title":"Parkinsons Dis"},{"issue":"1","key":"2990_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1258\/rsmmsl.46.1.37","volume":"46","author":"EA De Letter","year":"2006","unstructured":"De Letter EA, Piette MH, Lambert WE, Cordonnier JA (2006) Amphetamines as potential inducers of fatalities: a review in the district of Ghent from 1976\u20132004. Med Sci Law 46(1):37\u201365. https:\/\/doi.org\/10.1258\/rsmmsl.46.1.37","journal-title":"Med Sci Law"},{"issue":"12","key":"2990_CR18","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1007\/s00204-013-1082-9","volume":"87","author":"D Dias da Silva","year":"2013","unstructured":"Dias da Silva D, Carmo H, Lynch A, Silva E (2013a) An insight into the hepatocellular death induced by amphetamines, individually and in combination: the involvement of necrosis and apoptosis. Arch Toxicol 87(12):2165\u20132185. https:\/\/doi.org\/10.1007\/s00204-013-1082-9","journal-title":"Arch Toxicol"},{"issue":"6","key":"2990_CR19","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.tiv.2013.04.010","volume":"27","author":"D Dias da Silva","year":"2013","unstructured":"Dias da Silva D, Silva E, Carmo H (2013b) Cytotoxic effects of amphetamine mixtures in primary hepatocytes are severely aggravated under hyperthermic conditions. Toxicol In Vitro 27(6):1670\u20131678. https:\/\/doi.org\/10.1016\/j.tiv.2013.04.010","journal-title":"Toxicol In Vitro"},{"issue":"6","key":"2990_CR20","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/jat.2889","volume":"34","author":"D Dias da Silva","year":"2014","unstructured":"Dias da Silva D, Silva E, Carmo H (2014a) Combination effects of amphetamines under hyperthermia\u2014the role played by oxidative stress. J Appl Toxicol 34(6):637\u2013650. https:\/\/doi.org\/10.1002\/jat.2889","journal-title":"J Appl Toxicol"},{"issue":"6","key":"2990_CR21","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/jat.2885","volume":"34","author":"D Dias da Silva","year":"2014","unstructured":"Dias da Silva D, Silva E, Carvalho F, Carmo H (2014b) Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations. J Appl Toxicol 34(6):618\u2013627. https:\/\/doi.org\/10.1002\/jat.2885","journal-title":"J Appl Toxicol"},{"issue":"5","key":"2990_CR22","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.tiv.2015.04.001","volume":"29","author":"D Dias da Silva","year":"2015","unstructured":"Dias da Silva D, Arbo MD, Valente MJ, Bastos ML, Carmo H (2015) Hepatotoxicity of piperazine designer drugs: Comparison of different in vitro models. Toxicol In Vitro 29(5):987\u2013996. https:\/\/doi.org\/10.1016\/j.tiv.2015.04.001","journal-title":"Toxicol In Vitro"},{"issue":"3","key":"2990_CR23","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1007\/s00204-016-1777-9","volume":"91","author":"D Dias da Silva","year":"2017","unstructured":"Dias da Silva D, Silva MJ, Moreira P et al (2017) In vitro hepatotoxicity of \u201cLegal X\u201d: the combination of 1-benzylpiperazine (BZP) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) triggers oxidative stress, mitochondrial impairment and apoptosis. Arch Toxicol 91(3):1413\u20131430. https:\/\/doi.org\/10.1007\/s00204-016-1777-9","journal-title":"Arch Toxicol"},{"issue":"9","key":"2990_CR24","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1007\/s00204-019-02539-x","volume":"93","author":"D Dias da Silva","year":"2019","unstructured":"Dias da Silva D, Ferreira B, Roque Bravo R et al (2019) The new psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone) induces oxidative stress, apoptosis, and autophagy in primary rat hepatocytes at human-relevant concentrations. Arch Toxicol 93(9):2617\u20132634. https:\/\/doi.org\/10.1007\/s00204-019-02539-x","journal-title":"Arch Toxicol"},{"issue":"204","key":"2990_CR25","first-page":"65371","volume":"76","author":"Drug Enforcement Administration","year":"2011","unstructured":"Drug Enforcement Administration (2011) Schedules of controlled substances: temporary placement of three synthetic cathinones in Schedule I. Final Order. Fed Regist 76(204):65371\u201365375","journal-title":"Fed Regist"},{"issue":"4","key":"2990_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.pathophys.2011.04.001","volume":"18","author":"OS El-Tawil","year":"2011","unstructured":"El-Tawil OS, Abou-Hadeed AH, El-Bab MF, Shalaby AA (2011) d-Amphetamine-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. Pathophysiology 18(4):279\u2013285. https:\/\/doi.org\/10.1016\/j.pathophys.2011.04.001","journal-title":"Pathophysiology"},{"key":"2990_CR27","volume-title":"European Drug Report 2020: trends and development","author":"EMCDDA","year":"2020","unstructured":"EMCDDA (2020) European Drug Report 2020: trends and development. European Monitoring Centre for Drugs and Drug Addiction, Luxembourg"},{"key":"2990_CR28","unstructured":"EMCDDA-Europol (2011) EMCDDA\u2013Europol 2010 Annual Report on the implementation of Council Decision 2005\/387\/JHA, Lisbon"},{"issue":"1","key":"2990_CR29","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0169-409X(02)00173-4","volume":"55","author":"KN Faber","year":"2003","unstructured":"Faber KN, Muller M, Jansen PL (2003) Drug transport proteins in the liver. Adv Drug Deliv Rev 55(1):107\u2013124","journal-title":"Adv Drug Deliv Rev"},{"issue":"1\u20132","key":"2990_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","volume":"30","author":"HJ Forman","year":"2009","unstructured":"Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 30(1\u20132):1\u201312. https:\/\/doi.org\/10.1016\/j.mam.2008.08.006","journal-title":"Mol Aspects Med"},{"issue":"1","key":"2990_CR31","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s11845-010-0636-6","volume":"180","author":"S Frohlich","year":"2011","unstructured":"Frohlich S, Lambe E, O\u2019Dea J (2011) Acute liver failure following recreational use of psychotropic \u201chead shop\u201d compounds. Ir J Med Sci 180(1):263\u2013264. https:\/\/doi.org\/10.1007\/s11845-010-0636-6","journal-title":"Ir J Med Sci"},{"issue":"2","key":"2990_CR32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0379-0738(03)00179-8","volume":"135","author":"R Garcia-Repetto","year":"2003","unstructured":"Garcia-Repetto R, Moreno E, Soriano T, Jurado C, Gimenez MP, Menendez M (2003) Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose. Forensic Sci Int 135(2):110\u2013114","journal-title":"Forensic Sci Int"},{"key":"2990_CR33","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.forsciint.2018.07.001","volume":"290","author":"H Gaspar","year":"2018","unstructured":"Gaspar H, Bronze S, Oliveira C et al (2018) Proactive response to tackle the threat of emerging drugs: Synthesis and toxicity evaluation of new cathinones. Forensic Sci Int 290:146\u2013156. https:\/\/doi.org\/10.1016\/j.forsciint.2018.07.001","journal-title":"Forensic Sci Int"},{"issue":"2","key":"2990_CR34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10565-011-9208-4","volume":"28","author":"HH Gerets","year":"2012","unstructured":"Gerets HH, Tilmant K, Gerin B et al (2012) Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol 28(2):69\u201387. https:\/\/doi.org\/10.1007\/s10565-011-9208-4","journal-title":"Cell Biol Toxicol"},{"key":"2990_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jchromb.2016.09.027","volume":"1035","author":"L Glicksberg","year":"2016","unstructured":"Glicksberg L, Bryand K, Kerrigan S (2016) Identification and quantification of synthetic cathinones in blood and urine using liquid chromatography-quadrupole\/time of flight (LC-Q\/TOF) mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 1035:91\u2013103. https:\/\/doi.org\/10.1016\/j.jchromb.2016.09.027","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"3","key":"2990_CR36","first-page":"931","volume":"237","author":"CE Green","year":"1986","unstructured":"Green CE, LeValley SE, Tyson CA (1986) Comparison of amphetamine metabolism using isolated hepatocytes from five species including human. J Pharmacol Exp Ther 237(3):931\u2013936","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"2990_CR37","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cbi.2006.12.003","volume":"168","author":"A Guillouzo","year":"2007","unstructured":"Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168(1):66\u201373. https:\/\/doi.org\/10.1016\/j.cbi.2006.12.003","journal-title":"Chem Biol Interact"},{"key":"2990_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.forsciint.2014.02.022","volume":"243","author":"A Helander","year":"2014","unstructured":"Helander A, Backberg M, Hulten P, Al-Saffar Y, Beck O (2014) Detection of new psychoactive substance use among emergency room patients: results from the Swedish STRIDA project. Forensic Sci Int 243:23\u201329. https:\/\/doi.org\/10.1016\/j.forsciint.2014.02.022","journal-title":"Forensic Sci Int"},{"issue":"8","key":"2990_CR39","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1124\/dmd.107.014902","volume":"35","author":"C Hilgendorf","year":"2007","unstructured":"Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J (2007) Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos 35(8):1333\u20131340. https:\/\/doi.org\/10.1124\/dmd.107.014902","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"2990_CR40","first-page":"521","volume":"254","author":"M Hiramatsu","year":"1990","unstructured":"Hiramatsu M, Kumagai Y, Unger SE, Cho AK (1990) Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct. J Pharmacol Exp Ther 254(2):521\u2013527","journal-title":"J Pharmacol Exp Ther"},{"key":"2990_CR41","unstructured":"K\u00f6ppe H, Ludwig G, Zeile K (1967) Verfahren zur Herstellung von substituierten Phenyl-alpha-aminoketonen und deren S\u00e4ureadditionssalzen bzw. deren optischen Antipoden. Germany Patent DE1242241"},{"issue":"20","key":"2990_CR42","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.1523\/JNEUROSCI.22-20-08951.2002","volume":"22","author":"KE Larsen","year":"2002","unstructured":"Larsen KE, Fon EA, Hastings TG, Edwards RH, Sulzer D (2002) Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J Neurosci 22(20):8951\u20138960","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"2990_CR43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ejps.2006.01.004","volume":"28","author":"M Le Vee","year":"2006","unstructured":"Le Vee M, Jigorel E, Glaise D, Gripon P, Guguen-Guillouzo C, Fardel O (2006) Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line. Eur J Pharm Sci 28(1\u20132):109\u2013117. https:\/\/doi.org\/10.1016\/j.ejps.2006.01.004","journal-title":"Eur J Pharm Sci"},{"issue":"6","key":"2990_CR44","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/j.tiv.2013.07.003","volume":"27","author":"M Le Vee","year":"2013","unstructured":"Le Vee M, Noel G, Jouan E, Stieger B, Fardel O (2013) Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicol In Vitro 27(6):1979\u20131986. https:\/\/doi.org\/10.1016\/j.tiv.2013.07.003","journal-title":"Toxicol In Vitro"},{"issue":"2","key":"2990_CR45","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/BJ20111451","volume":"441","author":"J Lee","year":"2012","unstructured":"Lee J, Giordano S, Zhang J (2012) Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 441(2):523\u2013540. https:\/\/doi.org\/10.1042\/BJ20111451","journal-title":"Biochem J"},{"issue":"12","key":"2990_CR46","doi-asserted-by":"publisher","first-page":"e116565","DOI":"10.1371\/journal.pone.0116565","volume":"9","author":"IH Li","year":"2014","unstructured":"Li IH, Ma KH, Weng SJ, Huang SS, Liang CM, Huang YS (2014) Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy\u2019)-induced neurotoxicity in cultured cortical neurons. PLoS ONE 9(12):e116565. https:\/\/doi.org\/10.1371\/journal.pone.0116565","journal-title":"PLoS ONE"},{"issue":"1","key":"2990_CR47","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"key":"2990_CR48","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.tox.2017.06.004","volume":"387","author":"D Luethi","year":"2017","unstructured":"Luethi D, Liechti ME, Krahenbuhl S (2017) Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology 387:57\u201366. https:\/\/doi.org\/10.1016\/j.tox.2017.06.004","journal-title":"Toxicology"},{"issue":"Pt A","key":"2990_CR49","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.neuropharm.2017.07.026","volume":"134","author":"D Luethi","year":"2018","unstructured":"Luethi D, Kolaczynska KE, Docci L, Krahenbuhl S, Hoener MC, Liechti ME (2018) Pharmacological profile of mephedrone analogs and related new psychoactive substances. Neuropharmacology 134(Pt A):4\u201312. https:\/\/doi.org\/10.1016\/j.neuropharm.2017.07.026","journal-title":"Neuropharmacology"},{"key":"2990_CR50","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3389\/fphar.2019.00438","volume":"10","author":"D Luethi","year":"2019","unstructured":"Luethi D, Walter M, Zhou X, Rudin D, Krahenbuhl S, Liechti ME (2019) Para-halogenation affects monoamine transporter inhibition properties and hepatocellular toxicity of amphetamines and methcathinones. Front Pharmacol 10:438. https:\/\/doi.org\/10.3389\/fphar.2019.00438","journal-title":"Front Pharmacol"},{"issue":"7","key":"2990_CR51","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1007\/s00204-018-2227-7","volume":"92","author":"MJ Martins","year":"2018","unstructured":"Martins MJ, Roque Bravo R, Enea M et al (2018) Ethanol addictively enhances the in vitro cardiotoxicity of cocaine through oxidative damage, energetic deregulation, and apoptosis. Arch Toxicol 92(7):2311\u20132325. https:\/\/doi.org\/10.1007\/s00204-018-2227-7","journal-title":"Arch Toxicol"},{"issue":"12","key":"2990_CR52","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1038\/s41386-018-0053-5","volume":"43","author":"FP Mayer","year":"2018","unstructured":"Mayer FP, Schmid D, Owens WA et al (2018) An unsuspected role for organic cation transporter 3 in the actions of amphetamine. Neuropsychopharmacology 43(12):2408\u20132417. https:\/\/doi.org\/10.1038\/s41386-018-0053-5","journal-title":"Neuropsychopharmacology"},{"key":"2990_CR53","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.neuint.2018.09.008","volume":"123","author":"FP Mayer","year":"2019","unstructured":"Mayer FP, Schmid D, Holy M, Daws LC, Sitte HH (2019) \u201cPolytox\u201d synthetic cathinone abuse: a potential role for organic cation transporter 3 in combined cathinone-induced efflux. Neurochem Int 123:7\u201312. https:\/\/doi.org\/10.1016\/j.neuint.2018.09.008","journal-title":"Neurochem Int"},{"key":"2990_CR54","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neuint.2017.01.010","volume":"105","author":"LD Mercer","year":"2017","unstructured":"Mercer LD, Higgins GC, Lau CL, Lawrence AJ, Beart PM (2017) MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology. Neurochem Int 105:80\u201390. https:\/\/doi.org\/10.1016\/j.neuint.2017.01.010","journal-title":"Neurochem Int"},{"issue":"1","key":"2990_CR55","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0925-4439(02)00112-6","volume":"1588","author":"C Montiel-Duarte","year":"2002","unstructured":"Montiel-Duarte C, Varela-Rey M, Oses-Prieto JA et al (2002) 3,4-Methylenedioxymethamphetamine (\u201cEcstasy\u201d) induces apoptosis of cultured rat liver cells. Biochim Biophys Acta 1588(1):26\u201332","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"2990_CR56","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1007\/s00216-011-5678-8","volume":"402","author":"DM Mueller","year":"2012","unstructured":"Mueller DM, Rentsch KM (2012) Generation of metabolites by an automated online metabolism method using human liver microsomes with subsequent identification by LC-MS(n), and metabolism of 11 cathinones. Anal Bioanal Chem 402(6):2141\u20132151. https:\/\/doi.org\/10.1007\/s00216-011-5678-8","journal-title":"Anal Bioanal Chem"},{"issue":"1","key":"2990_CR57","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00204-008-0323-9","volume":"83","author":"Y Nakagawa","year":"2009","unstructured":"Nakagawa Y, Suzuki T, Tayama S, Ishii H, Ogata A (2009) Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes. Arch Toxicol 83(1):69\u201380. https:\/\/doi.org\/10.1007\/s00204-008-0323-9","journal-title":"Arch Toxicol"},{"issue":"12","key":"2990_CR58","doi-asserted-by":"publisher","first-page":"3448","DOI":"10.1016\/j.bbamcr.2013.06.001","volume":"1833","author":"V Nikoletopoulou","year":"1833","unstructured":"Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N (2013) Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta 1833(12):3448\u20133459. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.06.001","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"2990_CR59","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1124\/dmd.112.050880","volume":"41","author":"AJ Pedersen","year":"2013","unstructured":"Pedersen AJ, Petersen TH, Linnet K (2013a) In vitro metabolism and pharmacokinetic studies on methylone. Drug Metab Dispos 41(6):1247\u20131255. https:\/\/doi.org\/10.1124\/dmd.112.050880","journal-title":"Drug Metab Dispos"},{"issue":"6","key":"2990_CR60","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/dta.1369","volume":"5","author":"AJ Pedersen","year":"2013","unstructured":"Pedersen AJ, Reitzel LA, Johansen SS, Linnet K (2013b) In vitro metabolism studies on mephedrone and analysis of forensic cases. Drug Test Anal 5(6):430\u2013438. https:\/\/doi.org\/10.1002\/dta.1369","journal-title":"Drug Test Anal"},{"issue":"2","key":"2990_CR61","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2144\/000113610","volume":"50","author":"SW Perry","year":"2011","unstructured":"Perry SW, Norman JP, Barbieri J, Brown EB, Gelbard HA (2011) Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. Biotechniques 50(2):98\u2013115. https:\/\/doi.org\/10.2144\/000113610","journal-title":"Biotechniques"},{"issue":"1\u20133","key":"2990_CR62","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.tox.2008.07.064","volume":"252","author":"H Pontes","year":"2008","unstructured":"Pontes H, Duarte JA, de Pinho PG et al (2008) Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice. Toxicology 252(1\u20133):64\u201371. https:\/\/doi.org\/10.1016\/j.tox.2008.07.064","journal-title":"Toxicology"},{"key":"2990_CR63","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jpba.2017.05.028","volume":"143","author":"LHJ Richter","year":"2017","unstructured":"Richter LHJ, Flockerzi V, Maurer HH, Meyer MR (2017) Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples. J Pharm Biomed Anal 143:32\u201342. https:\/\/doi.org\/10.1016\/j.jpba.2017.05.028","journal-title":"J Pharm Biomed Anal"},{"key":"2990_CR64","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.toxlet.2018.11.007","volume":"301","author":"LHJ Richter","year":"2019","unstructured":"Richter LHJ, Beck A, Flockerzi V, Maurer HH, Meyer MR (2019) Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay. Toxicol Lett 301:79\u201389. https:\/\/doi.org\/10.1016\/j.toxlet.2018.11.007","journal-title":"Toxicol Lett"},{"issue":"2","key":"2990_CR65","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.tiv.2012.12.004","volume":"27","author":"RM Rodrigues","year":"2013","unstructured":"Rodrigues RM, Bouhifd M, Bories G et al (2013) Assessment of an automated in vitro basal cytotoxicity test system based on metabolically-competent cells. Toxicol In Vitro 27(2):760\u2013767. https:\/\/doi.org\/10.1016\/j.tiv.2012.12.004","journal-title":"Toxicol In Vitro"},{"issue":"1\u20133","key":"2990_CR66","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.forsciint.2012.04.034","volume":"222","author":"S Rojek","year":"2012","unstructured":"Rojek S, Klys M, Strona M, Maciow M, Kula K (2012) \u201cLegal highs\u201d\u2013toxicity in the clinical and medico-legal aspect as exemplified by suicide with bk-MBDB administration. Forensic Sci Int 222(1\u20133):e1-6. https:\/\/doi.org\/10.1016\/j.forsciint.2012.04.034","journal-title":"Forensic Sci Int"},{"key":"2990_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02638-9","author":"R Roque Bravo","year":"2019","unstructured":"Roque Bravo R, Carmo H, Silva JP et al (2019) Emerging club drugs: 5-(2-aminopropyl)benzofuran (5-APB) is more toxic than its isomer 6-(2-aminopropyl)benzofuran (6-APB) in hepatocyte cellular models. Arch Toxicol. https:\/\/doi.org\/10.1007\/s00204-019-02638-9","journal-title":"Arch Toxicol"},{"issue":"1","key":"2990_CR68","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11419-019-00494-x","volume":"38","author":"D Rouxinol","year":"2020","unstructured":"Rouxinol D, Carmo H, Carvalho F, Bastos MdL, Dias da Silva D (2020a) Pharmacokinetics, pharmacodynamics, and toxicity of the new psychoactive substance 3,4-dimethylmethcathinone (3,4-DMMC). Forensic Toxicol 38(1):15\u201329. https:\/\/doi.org\/10.1007\/s11419-019-00494-x","journal-title":"Forensic Toxicol"},{"key":"2990_CR69","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.toxlet.2019.10.003","volume":"320","author":"D Rouxinol","year":"2020","unstructured":"Rouxinol D, Dias da Silva D, Silva JP, Carvalho F, Bastos ML, Carmo H (2020b) Biodistribution and metabolic profile of 3,4-dimethylmethcathinone (3,4-DMMC) in Wistar rats through gas chromatography-mass spectrometry (GC-MS) analysis. Toxicol Lett 320:113\u2013123. https:\/\/doi.org\/10.1016\/j.toxlet.2019.10.003","journal-title":"Toxicol Lett"},{"issue":"1","key":"2990_CR70","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11419-012-0172-3","volume":"31","author":"N Shima","year":"2013","unstructured":"Shima N, Katagi M, Kamata H et al (2013) Urinary excretion and metabolism of the newly encountered designer drug 3,4-dimethylmethcathinone in humans. Forensic Toxicol 31(1):101\u2013112. https:\/\/doi.org\/10.1007\/s11419-012-0172-3","journal-title":"Forensic Toxicol"},{"issue":"2","key":"2990_CR71","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1476-5381.2012.02145.x","volume":"168","author":"LD Simmler","year":"2013","unstructured":"Simmler LD, Buser TA, Donzelli M et al (2013) Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol 168(2):458\u2013470. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02145.x","journal-title":"Br J Pharmacol"},{"key":"2990_CR72","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuropharm.2013.11.008","volume":"79","author":"LD Simmler","year":"2014","unstructured":"Simmler LD, Rickli A, Hoener MC, Liechti ME (2014) Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology 79:152\u2013160. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.11.008","journal-title":"Neuropharmacology"},{"issue":"4","key":"2990_CR73","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/jat\/bkv011","volume":"39","author":"M Sykutera","year":"2015","unstructured":"Sykutera M, Cychowska M, Bloch-Boguslawska E (2015) A fatal case of pentedrone and alpha-pyrrolidinovalerophenone poisoning. J Anal Toxicol 39(4):324\u2013329. https:\/\/doi.org\/10.1093\/jat\/bkv011","journal-title":"J Anal Toxicol"},{"issue":"5","key":"2990_CR74","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/jat\/bku021","volume":"38","author":"V Uralets","year":"2014","unstructured":"Uralets V, Rana S, Morgan S, Ross W (2014) Testing for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urine. J Anal Toxicol 38(5):233\u2013241. https:\/\/doi.org\/10.1093\/jat\/bku021","journal-title":"J Anal Toxicol"},{"issue":"4","key":"2990_CR75","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.legalmed.2014.03.008","volume":"16","author":"K Usui","year":"2014","unstructured":"Usui K, Aramaki T, Hashiyada M, Hayashizaki Y, Funayama M (2014) Quantitative analysis of 3,4-dimethylmethcathinone in blood and urine by liquid chromatography-tandem mass spectrometry in a fatal case. Leg Med (Tokyo) 16(4):222\u2013226. https:\/\/doi.org\/10.1016\/j.legalmed.2014.03.008","journal-title":"Leg Med (Tokyo)"},{"issue":"8","key":"2990_CR76","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s00204-015-1653-z","volume":"90","author":"MJ Valente","year":"2015","unstructured":"Valente MJ, Araujo AM, Silva R et al (2015) 3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions. Arch Toxicol 90(8):1959\u20131973. https:\/\/doi.org\/10.1007\/s00204-015-1653-z","journal-title":"Arch Toxicol"},{"issue":"1","key":"2990_CR77","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/toxsci\/kfw105","volume":"153","author":"MJ Valente","year":"2016","unstructured":"Valente MJ, Araujo AM, Bastos ML et al (2016) Characterization of hepatotoxicity mechanisms triggered by designer cathinone drugs (beta-keto amphetamines). Toxicol Sci 153(1):89\u2013102. https:\/\/doi.org\/10.1093\/toxsci\/kfw105","journal-title":"Toxicol Sci"},{"issue":"11","key":"2990_CR78","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1007\/s00204-017-1984-z","volume":"91","author":"MJ Valente","year":"2017","unstructured":"Valente MJ, Amaral C, Correia-da-Silva G et al (2017a) Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of beta-keto amphetamines-related neurotoxicity. Arch Toxicol 91(11):3663\u20133676. https:\/\/doi.org\/10.1007\/s00204-017-1984-z","journal-title":"Arch Toxicol"},{"issue":"4","key":"2990_CR79","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1021\/acschemneuro.6b00421","volume":"8","author":"MJ Valente","year":"2017","unstructured":"Valente MJ, Bastos ML, Fernandes E, Carvalho F, Guedes de Pinho P, Carvalho M (2017b) Neurotoxicity of beta-keto amphetamines: deathly mechanisms elicited by methylone and MDPV in human dopaminergic SH-SY5Y Cells. ACS Chem Neurosci 8(4):850\u2013859. https:\/\/doi.org\/10.1021\/acschemneuro.6b00421","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"2990_CR80","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s13181-011-0199-6","volume":"8","author":"BJ Warrick","year":"2012","unstructured":"Warrick BJ, Wilson J, Hedge M, Freeman S, Leonard K, Aaron C (2012) Lethal serotonin syndrome after methylone and butylone ingestion. J Med Toxicol 8(1):65\u201368. https:\/\/doi.org\/10.1007\/s13181-011-0199-6","journal-title":"J Med Toxicol"},{"key":"2990_CR81","unstructured":"Yokchue T, Anderson R (2015) In vitro metabolism studies on methylenedioxy-substituted amphetamines using human liver microsomes and LC\/MS\/MS with chemical derivatization. In: International association of forensic toxicologist meeting, Atlanta, GA, USA"},{"issue":"4","key":"2990_CR82","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.cld.2013.07.002","volume":"17","author":"L Yuan","year":"2013","unstructured":"Yuan L, Kaplowitz N (2013) Mechanisms of drug-induced liver injury. Clin Liver Dis 17(4):507\u2013518. https:\/\/doi.org\/10.1016\/j.cld.2013.07.002","journal-title":"Clin Liver Dis"},{"issue":"1\u20133","key":"2990_CR83","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.forsciint.2009.04.001","volume":"188","author":"K Zaitsu","year":"2009","unstructured":"Zaitsu K, Katagi M, Kamata HT et al (2009) Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine. Forensic Sci Int 188(1\u20133):131\u2013139. https:\/\/doi.org\/10.1016\/j.forsciint.2009.04.001","journal-title":"Forensic Sci Int"},{"issue":"1","key":"2990_CR84","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/cr.2017.133","volume":"28","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Chen X, Gueydan C, Han J (2018) Plasma membrane changes during programmed cell deaths. Cell Res 28(1):9\u201321. https:\/\/doi.org\/10.1038\/cr.2017.133","journal-title":"Cell Res"},{"issue":"1\u20133","key":"2990_CR85","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.forsciint.2012.08.034","volume":"227","author":"D Zuba","year":"2013","unstructured":"Zuba D, Adamowicz P, Byrska B (2013) Detection of buphedrone in biological and non-biological material\u2014two case reports. Forensic Sci Int 227(1\u20133):15\u201320. https:\/\/doi.org\/10.1016\/j.forsciint.2012.08.034","journal-title":"Forensic Sci Int"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-02990-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-021-02990-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-02990-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T06:04:45Z","timestamp":1617861885000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-021-02990-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,7]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2990"],"URL":"https:\/\/doi.org\/10.1007\/s00204-021-02990-9","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"type":"print","value":"0340-5761"},{"type":"electronic","value":"1432-0738"}],"subject":[],"published":{"date-parts":[[2021,2,7]]},"assertion":[{"value":"18 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declared that they have no conflicts of interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures involving animals were executed considering the highest standards of ethics, taking into consideration international, national and\/or institutional guidelines. Procedures were performed after approval by the local Ethical Committee for the Welfare of Experimental Animals (University of Porto-ORBEA; project 158\/2014) and by the national authority Dire\u00e7\u00e3o Geral de Alimenta\u00e7\u00e3o e Veterin\u00e1ria (DGAV).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}