{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:49:03Z","timestamp":1774633743674,"version":"3.50.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00204-022-03261-x","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T17:02:31Z","timestamp":1647709351000},"page":"1767-1782","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice"],"prefix":"10.1007","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-0681","authenticated-orcid":false,"given":"Ana","family":"Dias-Carvalho","sequence":"first","affiliation":[]},{"given":"Mariana","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Reis-Mendes","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Maria Lourdes","family":"Bastos","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Susana Isabel","family":"S\u00e1","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Paulo","family":"Capela","sequence":"additional","affiliation":[]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-2756","authenticated-orcid":false,"given":"Vera Marisa","family":"Costa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,3,19]]},"reference":[{"issue":"29","key":"3261_CR1","doi-asserted-by":"publisher","first-page":"4434","DOI":"10.1200\/jco.2009.27.0827","volume":"28","author":"TA Ahles","year":"2010","unstructured":"Ahles TA, Saykin AJ, McDonald BC et al (2010) Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol 28(29):4434\u20134440. https:\/\/doi.org\/10.1200\/jco.2009.27.0827","journal-title":"J Clin Oncol"},{"key":"3261_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108334","volume":"181","author":"MA Ali","year":"2020","unstructured":"Ali MA, Menze ET, Tadros MG, Tolba MF (2020) Caffeic acid phenethyl ester counteracts doxorubicin-induced chemobrain in Sprague-Dawley rats: emphasis on the modulation of oxidative stress and neuroinflammation. Neuropharmacology 181:108334. https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108334","journal-title":"Neuropharmacology"},{"issue":"2","key":"3261_CR3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/ph11020041","volume":"11","author":"D Almeida","year":"2018","unstructured":"Almeida D, Pinho R, Correia V et al (2018) Mitoxantrone is more toxic than doxorubicin in SH-SY5Y human cells: a \u2018chemobrain\u2019in vitro study. Pharmaceuticals 11(2):41. https:\/\/doi.org\/10.3390\/ph11020041","journal-title":"Pharmaceuticals"},{"key":"3261_CR4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/978-3-030-15935-1_21","volume-title":"Cancer survivorship fundamentals of cancer prevention","author":"A Barrie","year":"2019","unstructured":"Barrie A, Plaxe S, Krouse R, Aziz NM (2019) Cancer survivorship fundamentals of cancer prevention. Springer, Berlin, pp 723\u2013769"},{"key":"3261_CR5","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/B978-0-12-397266-8.00102-2","volume-title":"Cellular migration and formation of neuronal connections","author":"SL Barrow","year":"2013","unstructured":"Barrow SL, McAllister AK (2013) Molecular composition of developing glutamatergic synapses. In: Rubenstein JLR, Rakic P (eds) Cellular migration and formation of neuronal connections. Academic Press, Oxford, pp 497\u2013519"},{"issue":"3\u20134","key":"3261_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3109\/03602538608998294","volume":"17","author":"VK Batra","year":"1986","unstructured":"Batra VK, Morrison JA, Woodward DL, Siverd NS, Yacobi A (1986) Pharmacokinetics of mitoxantrone in man and laboratory animals. Drug Metab Rev 17(3\u20134):311\u2013329. https:\/\/doi.org\/10.3109\/03602538608998294","journal-title":"Drug Metab Rev"},{"key":"3261_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00088","author":"A Becerra-Calixto","year":"2017","unstructured":"Becerra-Calixto A, Cardona-G\u00f3mez GP (2017) The role of astrocytes in neuroprotection after brain stroke: potential in cell therapy. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2017.00088","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"3261_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s11060-005-3030-x","volume":"75","author":"A Boiardi","year":"2005","unstructured":"Boiardi A, Eoli M, Salmaggi A et al (2005) Systemic temozolomide combined with loco-regional mitoxantrone in treating recurrent glioblastoma. J Neurooncol 75(2):215\u2013220. https:\/\/doi.org\/10.1007\/s11060-005-3030-x","journal-title":"J Neurooncol"},{"key":"3261_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152852","volume":"459","author":"SR Brand\u00e3o","year":"2021","unstructured":"Brand\u00e3o SR, Reis-Mendes A, Domingues P et al (2021) Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model. Toxicology 459:152852. https:\/\/doi.org\/10.1016\/j.tox.2021.152852","journal-title":"Toxicology"},{"issue":"1","key":"3261_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.tips.2005.11.009","volume":"27","author":"P Breedveld","year":"2006","unstructured":"Breedveld P, Beijnen JH, Schellens JH (2006) Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs. Trends Pharmacol Sci 27(1):17\u201324. https:\/\/doi.org\/10.1016\/j.tips.2005.11.009","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"3261_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1517\/14728222.11.2.123","volume":"11","author":"S Camandola","year":"2007","unstructured":"Camandola S, Mattson MP (2007) NF-kappa B as a therapeutic target in neurodegenerative diseases. Expert Opin Ther Targets 11(2):123\u2013132. https:\/\/doi.org\/10.1517\/14728222.11.2.123","journal-title":"Expert Opin Ther Targets"},{"issue":"3","key":"3261_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1080\/13803395.2018.1546381","volume":"41","author":"N Cerulla","year":"2019","unstructured":"Cerulla N, Arcusa A, Navarro JB et al (2019) Cognitive impairment following chemotherapy for breast cancer: the impact of practice effect on results. J Clin Exp Neuropsychol 41(3):290\u2013299. https:\/\/doi.org\/10.1080\/13803395.2018.1546381","journal-title":"J Clin Exp Neuropsychol"},{"key":"3261_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2019.09.016","author":"BT Chen","year":"2019","unstructured":"Chen BT, Ye N, Wong CW et al (2019) Effects of chemotherapy on aging white matter microstructure: a longitudinal diffusion tensor imaging study. J Geriatr Oncol. https:\/\/doi.org\/10.1016\/j.jgo.2019.09.016","journal-title":"J Geriatr Oncol"},{"issue":"7","key":"3261_CR14","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1093\/annonc\/mdv206","volume":"26","author":"YT Cheung","year":"2015","unstructured":"Cheung YT, Ng T, Shwe M et al (2015) Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study. Ann Oncol 26(7):1446\u20131451. https:\/\/doi.org\/10.1093\/annonc\/mdv206","journal-title":"Ann Oncol"},{"issue":"5660","key":"3261_CR15","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1126\/science.1092734","volume":"303","author":"JE Chipuk","year":"2004","unstructured":"Chipuk JE, Kuwana T, Bouchier-Hayes L et al (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303(5660):1010\u20131014. https:\/\/doi.org\/10.1126\/science.1092734","journal-title":"Science"},{"issue":"8","key":"3261_CR16","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1021\/tx7000916","volume":"20","author":"VM Costa","year":"2007","unstructured":"Costa VM, Silva R, Ferreira LM et al (2007) Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: formation of adrenochrome, quinoproteins, and GSH adduct. Chem Res Toxicol 20(8):1183\u20131191. https:\/\/doi.org\/10.1021\/tx7000916","journal-title":"Chem Res Toxicol"},{"issue":"3","key":"3261_CR17","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1046\/j.1365-2818.1999.00460.x","volume":"193","author":"LM Cruz-orive","year":"1999","unstructured":"Cruz-orive LM (1999) Precision of Cavalieri sections and slices with local errors. J Microsc 193(3):182\u2013198. https:\/\/doi.org\/10.1046\/j.1365-2818.1999.00460.x","journal-title":"J Microsc"},{"key":"3261_CR18","doi-asserted-by":"publisher","unstructured":"Curry SH, McCarthy D, DeCory HH, Marler M, Gabrielsson J (2007) Phase I: The First Opportunity for Extrapolation from Animal Data to Human Exposure Principles and Practice of Pharmaceutical Medicine. pp 79\u2013100 https:\/\/doi.org\/10.1002\/9780470093153","DOI":"10.1002\/9780470093153"},{"key":"3261_CR19","doi-asserted-by":"publisher","DOI":"10.5772\/67267","author":"M Dagdeviren","year":"2017","unstructured":"Dagdeviren M (2017) Role of nitric oxide synthase in normal brain function and pathophysiology of neural diseases. Nitric Oxide Synthase-Simple Enzyme-Complex Roles. https:\/\/doi.org\/10.5772\/67267","journal-title":"Nitric Oxide Synthase-Simple Enzyme-Complex Roles"},{"key":"3261_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00204-021-03171-4","volume":"96","author":"A Dias-Carvalho","year":"2021","unstructured":"Dias-Carvalho A, Ferreira M, Ferreira R et al (2022) Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events. Arch Toxicol\u00a096:11\u201378. https:\/\/doi.org\/10.1007\/s00204-021-03171-4\u00a0","journal-title":"Arch Toxicol"},{"key":"3261_CR21","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.tox.2015.01.006","volume":"329","author":"JL Dores-Sousa","year":"2015","unstructured":"Dores-Sousa JL, Duarte JA, Seabra V, de Lourdes BM, Carvalho F, Costa VM (2015) The age factor for mitoxantrone\u2019s cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury. Toxicology 329:106\u2013119. https:\/\/doi.org\/10.1016\/j.tox.2015.01.006","journal-title":"Toxicology"},{"issue":"47","key":"3261_CR22","doi-asserted-by":"publisher","first-page":"7340","DOI":"10.1038\/sj.onc.1206938","volume":"22","author":"LA Doyle","year":"2003","unstructured":"Doyle LA, Ross DD (2003) Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22(47):7340\u20137358. https:\/\/doi.org\/10.1038\/sj.onc.1206938","journal-title":"Oncogene"},{"issue":"2","key":"3261_CR23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/med.21364","volume":"36","author":"BJ Evison","year":"2016","unstructured":"Evison BJ, Sleebs BE, Watson KG, Phillips DR, Cutts SM (2016) Mitoxantrone, more than just another topoisomerase II poison. Med Res Rev 36(2):248\u2013299. https:\/\/doi.org\/10.1002\/med.21364","journal-title":"Med Res Rev"},{"issue":"1","key":"3261_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF00163544","volume":"6","author":"R Green","year":"1988","unstructured":"Green R, Stewart D, Hugenholtz H, Richard M, Thibault M, Montpetit V (1988) Human central nervous system and plasma pharmacology of mitoxantrone. J Neurooncol 6(1):75\u201383. https:\/\/doi.org\/10.1007\/BF00163544","journal-title":"J Neurooncol"},{"issue":"3","key":"3261_CR25","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","volume":"147","author":"HJG Gundersen","year":"1987","unstructured":"Gundersen HJG, Jensen E (1987) The efficiency of systematic sampling in stereology and its prediction. J Microsc 147(3):229\u2013263. https:\/\/doi.org\/10.1111\/j.1365-2818.1987.tb02837.x","journal-title":"J Microsc"},{"issue":"2","key":"3261_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.expneurol.2009.09.011","volume":"223","author":"F Hern\u00e1ndez","year":"2010","unstructured":"Hern\u00e1ndez F, G\u00f3mez de Barreda E, Fuster-Matanzo A, Lucas JJ, Avila J (2010) GSK3: a possible link between beta amyloid peptide and tau protein. Exp Neurol 223(2):322\u2013325. https:\/\/doi.org\/10.1016\/j.expneurol.2009.09.011","journal-title":"Exp Neurol"},{"issue":"2","key":"3261_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1080\/03602532.2017.1316285","volume":"49","author":"I Hrynchak","year":"2017","unstructured":"Hrynchak I, Sousa E, Pinto M, Costa VM (2017) The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs. Drug Metab Rev 49(2):158\u2013196. https:\/\/doi.org\/10.1080\/03602532.2017.1316285","journal-title":"Drug Metab Rev"},{"issue":"3","key":"3261_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.124","volume":"10","author":"C Hu","year":"2020","unstructured":"Hu C, Zhang X, Zhang N et al (2020) Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity. Clin Transl Med 10(3):e124. https:\/\/doi.org\/10.1002\/ctm2.124","journal-title":"Clin Transl Med"},{"issue":"2","key":"3261_CR29","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/cncr.20385","volume":"101","author":"G Iconomou","year":"2004","unstructured":"Iconomou G, Mega V, Koutras A, Iconomou AV, Kalofonos HP (2004) Prospective assessment of emotional distress, cognitive function, and quality of life in patients with cancer treated with chemotherapy. Cancer 101(2):404\u2013411","journal-title":"Cancer"},{"issue":"5259","key":"3261_CR30","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680\u2013685. https:\/\/doi.org\/10.1038\/227680a0","journal-title":"Nature"},{"issue":"4","key":"3261_CR31","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/ijc.2910590418","volume":"59","author":"F L\u00e9vi","year":"1994","unstructured":"L\u00e9vi F, Tampellini M, Metzger G, Bizi E, Lemaigre G, Hallek M (1994) Circadian changes in mitoxantrone toxicity in mice: relationship with plasma pharmacokinetics. Int J Cancer 59(4):543\u2013547. https:\/\/doi.org\/10.1002\/ijc.2910590418","journal-title":"Int J Cancer"},{"key":"3261_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","volume":"21","author":"WJ Liu","year":"2016","unstructured":"Liu WJ, Ye L, Huang WF et al (2016) p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cell Mol Biol Lett 21:29. https:\/\/doi.org\/10.1186\/s11658-016-0031-z","journal-title":"Cell Mol Biol Lett"},{"issue":"11","key":"3261_CR33","doi-asserted-by":"publisher","first-page":"4704","DOI":"10.1007\/s12035-020-02034-w","volume":"57","author":"M Liu","year":"2020","unstructured":"Liu M, Sui D, Dexheimer T et al (2020) Hyperphosphorylation renders tau prone to aggregate and to cause cell death. Mol Neurobiol 57(11):4704\u20134719. https:\/\/doi.org\/10.1007\/s12035-020-02034-w","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3261_CR34","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s40478-018-0604-3","volume":"6","author":"J Ma","year":"2018","unstructured":"Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ (2018) Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Acta Neuropathol Commun 6(1):103. https:\/\/doi.org\/10.1186\/s40478-018-0604-3","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"3261_CR35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1447-073x.2005.00121.x","volume":"80","author":"T Miki","year":"2005","unstructured":"Miki T, Satriotomo I, Li H-P et al (2005) Application of the physical disector to the central nervous system: estimation of the total number of neurons in subdivisions of the rat hippocampus. Anat Sci Int 80(3):153. https:\/\/doi.org\/10.1111\/j.1447-073x.2005.00121.x","journal-title":"Anat Sci Int"},{"issue":"5","key":"3261_CR36","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3322\/caac.21565","volume":"69","author":"KD Miller","year":"2019","unstructured":"Miller KD, Nogueira L, Mariotto AB et al (2019) Cancer treatment and survivorship statistics, 2019. CA: Cancer J Clin 69(5):363\u2013385. https:\/\/doi.org\/10.3322\/caac.21565","journal-title":"CA: Cancer J Clin"},{"issue":"6","key":"3261_CR37","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1191\/1352458503ms965oa","volume":"9","author":"A Minagar","year":"2003","unstructured":"Minagar A, Alexander JS (2003) Blood-brain barrier disruption in multiple sclerosis. Mult Scler J 9(6):540\u2013549. https:\/\/doi.org\/10.1191\/1352458503ms965oa","journal-title":"Mult Scler J"},{"issue":"12","key":"3261_CR38","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.18632\/aging.101144","volume":"8","author":"JF Moruno-Manchon","year":"2016","unstructured":"Moruno-Manchon JF, Uzor NE, Kesler SR et al (2016) TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin. Aging 8(12):3507\u20133519. https:\/\/doi.org\/10.18632\/aging.101144","journal-title":"Aging"},{"issue":"1","key":"3261_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jns.2004.04.015","volume":"223","author":"O Neuhaus","year":"2004","unstructured":"Neuhaus O, Kieseier BC, Hartung H-P (2004) Mechanisms of mitoxantrone in multiple sclerosis\u2013what is known? J Neurol Sci 223(1):25\u201327. https:\/\/doi.org\/10.1016\/j.jns.2004.04.015","journal-title":"J Neurol Sci"},{"issue":"1","key":"3261_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/bmc-2019-0001","volume":"10","author":"P Neupane","year":"2019","unstructured":"Neupane P, Bhuju S, Thapa N, Bhattarai HK (2019) ATP synthase: structure, function and inhibition. Biomol Concepts 10(1):1\u201310. https:\/\/doi.org\/10.1515\/bmc-2019-0001","journal-title":"Biomol Concepts"},{"key":"3261_CR41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuropharm.2018.02.013","volume":"133","author":"HS Park","year":"2018","unstructured":"Park HS, Kim CJ, Kwak HB, No MH, Heo JW, Kim TW (2018) Physical exercise prevents cognitive impairment by enhancing hippocampal neuroplasticity and mitochondrial function in doxorubicin-induced chemobrain. Neuropharmacology 133:451\u2013461. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.02.013","journal-title":"Neuropharmacology"},{"issue":"2","key":"3261_CR42","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1136\/jnnp.2006.091033","volume":"78","author":"F Paul","year":"2007","unstructured":"Paul F, D\u00f6rr J, W\u00fcrfel J, Vogel H, Zipp F (2007) Early mitoxantrone-induced cardiotoxicity in secondary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 78(2):198\u2013200. https:\/\/doi.org\/10.1136\/jnnp.2006.091033","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3261_CR43","volume-title":"Paxinos and Franklin's the mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2019","unstructured":"Paxinos G, Franklin KB (2019) Paxinos and Franklin\u2019s the mouse brain in stereotaxic coordinates. Academic press, Cambridge"},{"issue":"3","key":"3261_CR44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22(3):659\u2013661. https:\/\/doi.org\/10.1096\/fj.07-9574LSF","journal-title":"FASEB J"},{"issue":"8","key":"3261_CR45","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1080\/01616412.2016.1203124","volume":"38","author":"EC Rebou\u00e7as","year":"2016","unstructured":"Rebou\u00e7as EC, Leal S, S\u00e1 SI (2016) Regulation of NPY and \u03b1-MSH expression by estradiol in the arcuate nucleus of Wistar female rats: a stereological study. Neurol Res 38(8):740\u2013747. https:\/\/doi.org\/10.1080\/01616412.2016.1203124","journal-title":"Neurol Res"},{"issue":"4","key":"3261_CR46","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s00204-016-1839-z","volume":"91","author":"A Reis-Mendes","year":"2017","unstructured":"Reis-Mendes A, Gomes A, Carvalho R et al (2017) Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy. Arch Toxicol 91(4):1871\u20131890. https:\/\/doi.org\/10.1007\/s00204-016-1839-z","journal-title":"Arch Toxicol"},{"issue":"6","key":"3261_CR47","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3390\/ph14060510","volume":"14","author":"A Reis-Mendes","year":"2021","unstructured":"Reis-Mendes A, Dores-Sousa JL, Padr\u00e3o AI et al (2021) Inflammation as a possible trigger for mitoxantrone-induced cardiotoxicity: an in vivo study in adult and infant mice. Pharmaceuticals 14(6):510. https:\/\/doi.org\/10.3390\/ph14060510","journal-title":"Pharmaceuticals"},{"key":"3261_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.12.029","volume":"134","author":"X Ren","year":"2019","unstructured":"Ren X, Keeney JTR, Miriyala S et al (2019) The triangle of death of neurons: oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment (\u201cchemobrain\u201d) involving TNF-alpha. Free Radical Biol Med 134:1\u20138. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.12.029","journal-title":"Free Radical Biol Med"},{"issue":"9","key":"3261_CR49","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1093\/annonc\/mdf241","volume":"13","author":"S Schagen","year":"2002","unstructured":"Schagen S, Muller M, Boogerd W et al (2002) Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients. Ann Oncol 13(9):1387\u20131397","journal-title":"Ann Oncol"},{"issue":"6","key":"3261_CR50","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2165\/00023210-200418060-00010","volume":"18","author":"LJ Scott","year":"2004","unstructured":"Scott LJ, Figgitt DP (2004) Mitoxantrone. CNS Drugs 18(6):379\u2013396. https:\/\/doi.org\/10.2165\/00023210-200418060-00010","journal-title":"CNS Drugs"},{"issue":"2","key":"3261_CR51","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1517\/14740338.4.2.219","volume":"4","author":"K Seiter","year":"2005","unstructured":"Seiter K (2005) Toxicity of the topoisomerase II inhibitors. Expert Opin Drug Saf 4(2):219\u2013234. https:\/\/doi.org\/10.1517\/14740338.4.2.219","journal-title":"Expert Opin Drug Saf"},{"issue":"6","key":"3261_CR52","first-page":"624","volume":"4","author":"P Sengupta","year":"2013","unstructured":"Sengupta P (2013) The laboratory rat: relating its age with human\u2019s. Int J Prev Med 4(6):624","journal-title":"Int J Prev Med"},{"issue":"19","key":"3261_CR53","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1200\/JCO.2014.58.2320","volume":"33","author":"Y-CT Shih","year":"2015","unstructured":"Shih Y-CT, Smieliauskas F, Geynisman DM, Kelly RJ, Smith TJ (2015) Trends in the cost and use of targeted cancer therapies for the privately insured nonelderly: 2001 to 2011. J Clin Oncol 33(19):2190. https:\/\/doi.org\/10.1200\/JCO.2014.58.2320","journal-title":"J Clin Oncol"},{"issue":"32","key":"3261_CR54","doi-asserted-by":"publisher","first-page":"9717","DOI":"10.1021\/bi060485p","volume":"45","author":"HS Smallwood","year":"2006","unstructured":"Smallwood HS, Shi L, Squier TC (2006) Increases in calmodulin abundance and stabilization of activated inducible nitric oxide synthase mediate bacterial killing in RAW 264.7 macrophages. Biochemistry 45(32):9717\u20139726. https:\/\/doi.org\/10.1021\/bi060485p","journal-title":"Biochemistry"},{"issue":"9701","key":"3261_CR55","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/S0140-6736(09)61299-X","volume":"374","author":"C Soussain","year":"2009","unstructured":"Soussain C, Ricard D, Fike JR, Mazeron J-J, Psimaras D, Delattre J-Y (2009) CNS complications of radiotherapy and chemotherapy. Lancet 374(9701):1639\u20131651. https:\/\/doi.org\/10.1016\/S0140-6736(09)61299-X","journal-title":"Lancet"},{"issue":"11","key":"3261_CR56","first-page":"1255","volume":"70","author":"D Stewart","year":"1986","unstructured":"Stewart D, Green R, Mikhael N, Montpetit V, Thibault M, Maroun J (1986) Human autopsy tissue concentrations of mitoxantrone. Cancer Treat Rep 70(11):1255\u20131261","journal-title":"Cancer Treat Rep"},{"issue":"3","key":"3261_CR57","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA: Cancer J Clin"},{"issue":"6","key":"3261_CR58","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.3324\/haematol.2011.045583","volume":"96","author":"F Taube","year":"2011","unstructured":"Taube F, St\u00f6lzel F, Thiede C, Ehninger G, Laniado M, Schaich M (2011) Increased incidence of central nervous system hemorrhages in patients with secondary acute promyelocytic leukemia after treatment of multiple sclerosis with mitoxantrone? Haematologica 96(6):e31\u2013e31. https:\/\/doi.org\/10.3324\/haematol.2011.045583","journal-title":"Haematologica"},{"issue":"1","key":"3261_CR59","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1755-1536-5-7","volume":"5","author":"A Vidyasagar","year":"2012","unstructured":"Vidyasagar A, Wilson NA, Djamali A (2012) Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target. Fibrogenesis Tissue Repair 5(1):7. https:\/\/doi.org\/10.1186\/1755-1536-5-7","journal-title":"Fibrogenesis Tissue Repair"},{"key":"3261_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117242","volume":"242","author":"S Wang","year":"2020","unstructured":"Wang S, Lai X, Deng Y, Song Y (2020) Correlation between mouse age and human age in anti-tumor research: significance and method establishment. Life Sci 242:117242. https:\/\/doi.org\/10.1016\/j.lfs.2019.117242","journal-title":"Life Sci"},{"issue":"3","key":"3261_CR61","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/cncr.20393","volume":"101","author":"JS Wefel","year":"2004","unstructured":"Wefel JS, Lenzi R, Theriault R, Buzdar AU, Cruickshank S, Meyers CA (2004a) \u201cChemobrain\u201d in breast carcinoma? a prologue. Cancer 101(3):466\u2013475. https:\/\/doi.org\/10.1002\/cncr.20393","journal-title":"Cancer"},{"issue":"11","key":"3261_CR62","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1002\/cncr.20272","volume":"100","author":"JS Wefel","year":"2004","unstructured":"Wefel JS, Lenzi R, Theriault RL, Davis RN, Meyers CA (2004b) The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer 100(11):2292\u20132299. https:\/\/doi.org\/10.1002\/cncr.20272","journal-title":"Cancer"},{"issue":"1","key":"3261_CR63","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/pon.2960040108","volume":"4","author":"MH Wieneke","year":"1995","unstructured":"Wieneke MH, Dienst ER (1995) Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer. Psychooncology 4(1):61\u201366. https:\/\/doi.org\/10.1002\/pon.2960040108","journal-title":"Psychooncology"},{"issue":"1","key":"3261_CR64","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.bbrc.2019.10.114","volume":"521","author":"B Xie","year":"2020","unstructured":"Xie B, He X, Guo G et al (2020) High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement. Biochem Biophys Res Commun 521(1):232\u2013237. https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.114","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"3261_CR65","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1159\/000485580","volume":"44","author":"K Yang","year":"2017","unstructured":"Yang K, Chen Z, Gao J et al (2017) The key roles of GSK-3\u03b2 in regulating mitochondrial activity. Cell Physiol Biochem 44(4):1445\u20131459. https:\/\/doi.org\/10.1159\/000485580","journal-title":"Cell Physiol Biochem"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03261-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-022-03261-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03261-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T18:08:30Z","timestamp":1652292510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-022-03261-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,19]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["3261"],"URL":"https:\/\/doi.org\/10.1007\/s00204-022-03261-x","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,19]]},"assertion":[{"value":"5 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of the local animal welfare body (ICBAS-UP ORBEA) and the Portuguese national authority for animal health (DGAV, process no. 0421\/000\/000\/2016).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}