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One of those is the burden of neurologic disorders. While many hypotheses have been placed to explain aging mechanisms, it has been widely accepted that the increasing pro-inflammatory status with advanced age or \u201cinflammaging\u201d is a main determinant of biological aging. Furthermore, <jats:italic>inflammaging<\/jats:italic> is at the cornerstone of many age-related diseases and its involvement in neurologic disorders is an exciting hypothesis. Indeed, aging and neurologic disorders development in the elderly seem to share some basic pathways that fundamentally converge on inflammation. Peripheral inflammation significantly influences brain function and contributes to the development of neurological disorders, including Alzheimer\u2019s disease, Parkinson\u2019s disease, and multiple sclerosis. 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