{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:17:03Z","timestamp":1761707823612},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn Schmied Arch Pharmacol"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1007\/s00210-005-0012-7","type":"journal-article","created":{"date-parts":[[2005,9,28]],"date-time":"2005-09-28T06:02:30Z","timestamp":1127887350000},"page":"147-152","source":"Crossref","is-referenced-by-count":19,"title":["Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells"],"prefix":"10.1007","volume":"372","author":[{"given":"R.","family":"Monteiro","sequence":"first","affiliation":[]},{"given":"C.","family":"Calhau","sequence":"additional","affiliation":[]},{"given":"F.","family":"Martel","sequence":"additional","affiliation":[]},{"given":"A.","family":"Faria","sequence":"additional","affiliation":[]},{"given":"N.","family":"Mateus","sequence":"additional","affiliation":[]},{"given":"I.","family":"Azevedo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,9,29]]},"reference":[{"key":"12_CR1","first-page":"305","volume":"8","author":"P Artursson","year":"1991","unstructured":"Artursson P (1991) Cell cultures as models for drug absorption across the intestinal mucosa. Crit Rev Ther Drug Carrier Syst 8:305\u2013330","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"12_CR2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0006-291X(91)91647-U","volume":"175","author":"P Artursson","year":"1991","unstructured":"Artursson P, Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal (Caco-2) cells. Biochem Biophys Res Commun 175:880\u2013885","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.foodres.2003.11.008","volume":"37","author":"C Auger","year":"2004","unstructured":"Auger C, Al-Awwadi N, Bornet A, Rouanet J, Gasc F, Cros G, Teissedre F (2004) Catechins and procyanidins in Mediterranean diets. Food Res Int 37:233\u2013245","journal-title":"Food Res Int"},{"key":"12_CR4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/B978-0-12-091302-2.50010-4","volume-title":"Methods in enzymatic analysis","author":"HU Bergmeyer","year":"1974","unstructured":"Bergmeyer HU, Bernt E (1974) Lactate dehydrogenase. In: Bergmeyer HU (ed) Methods in enzymatic analysis. Academic, New York, pp 574\u2013579"},{"key":"12_CR5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"12_CR6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00424-004-1355-5","volume":"449","author":"G Ciarimboli","year":"2005","unstructured":"Ciarimboli G, Schlatter E (2005) Regulation of organic cation transport. Pfl\u00fcgers Arch 449:423\u2013441","journal-title":"Pfl\u00fcgers Arch"},{"key":"12_CR7","first-page":"221","volume":"18","author":"G Darn\u00e9","year":"1979","unstructured":"Darn\u00e9 G, Madero-Tamargo J (1979) Mise au point d'une m\u00e9thode d'extraction des lipides solubles totaux, des glucides solubles totaux et des compos\u00e9s ph\u00e9noliques solubles totaux des organes de la vigne. Vitis 18:221\u2013228","journal-title":"Vitis"},{"key":"12_CR8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1211\/002235702603","volume":"55","author":"S Deferme","year":"2003","unstructured":"Deferme S, Augustijns P (2003) The effect of food components on the absorption of P-gp substrates: a review. J Pharm Pharmacol 55:153\u2013162","journal-title":"J Pharm Pharmacol"},{"key":"12_CR9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v14.i3.20","volume":"14","author":"F Delie","year":"1997","unstructured":"Delie F, Rubas W (1997) A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model. Crit Rev Ther Drug Carrier Syst 14:221\u2013286","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"12_CR10","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1021\/jf000549h","volume":"48","author":"S Pascual-Teresa de","year":"2000","unstructured":"De Pascual-Teresa S, Santos-Buelga C, Rivas-Gonzalo JC (2000) Quantitative analysis of flavan-3-ols in Spanish foodstuffs and beverages. J Agric Food Chem 48:5331\u20135337","journal-title":"J Agric Food Chem"},{"key":"12_CR11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/1557","volume":"1","author":"D Gr\u00fcndemann","year":"1998","unstructured":"Gr\u00fcndemann D, Schechinger B, Rappold GA, Sch\u00f6mig E (1998) Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1:349\u2013351","journal-title":"Nat Neurosci"},{"key":"12_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.56.1.1","volume":"56","author":"D Gr\u00fcndemann","year":"1999","unstructured":"Gr\u00fcndemann D, Liebich G, Kiefe N, K\u00f6ster S, Sch\u00f6mig E (1999) Selective substracts for non-neuronal monoamine transporters. Mol Pharmacol 56:1\u201310","journal-title":"Mol Pharmacol"},{"key":"12_CR13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.2165\/00003088-200342130-00001","volume":"42","author":"RZ Harris","year":"2003","unstructured":"Harris RZ, Jang GR, Tsunoda S (2003) Dietary effects on drug metabolism and transport. Clin Pharmacokinet 42:1071\u20131088","journal-title":"Clin Pharmacokinet"},{"key":"12_CR14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0016-5085(89)90897-4","volume":"96","author":"IJ Hidalgo","year":"1989","unstructured":"Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterisation of the human colonic carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736\u2013749","journal-title":"Gastroenterology"},{"key":"12_CR15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0304-3940(89)90445-X","volume":"101","author":"I Irwin","year":"1989","unstructured":"Irwin I, DeLanney LE, Di Monte D, Langston JW (1989) The biodisposition of MPP+ in mouse brain. Neurosci Lett 101:83\u201388","journal-title":"Neurosci Lett"},{"key":"12_CR16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0167-4889(01)00175-6","volume":"1542","author":"J Jodoin","year":"2002","unstructured":"Jodoin J, Demeule M, Beliveau R (2002) Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta 1542:149\u2013159","journal-title":"Biochim Biophys Acta"},{"key":"12_CR17","doi-asserted-by":"crossref","first-page":"15971","DOI":"10.1074\/jbc.273.26.15971","volume":"273","author":"R Kekuda","year":"1998","unstructured":"Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971\u201315979","journal-title":"J Biol Chem"},{"key":"12_CR18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tips.2004.05.005","volume":"25","author":"H Koepsell","year":"2004","unstructured":"Koepsell H (2004) Polyspecific organic cation transporters: their functions and interactions with drugs. Trends Pharmacol Sci 25:375\u2013381","journal-title":"Trends Pharmacol Sci"},{"key":"12_CR19","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1021\/jf0008487","volume":"48","author":"R Kuruto-Niwa","year":"2000","unstructured":"Kuruto-Niwa R, Inoue S, Ogawa S, Muramatsu M, Nozawa R (2000) Effects of tea catechins on the ERE-regulated estrogenic activity. J Agric Food Chem 48:6355\u20136361","journal-title":"J Agric Food Chem"},{"issue":"Suppl 2","key":"12_CR20","first-page":"S41","volume":"11","author":"VH Lee","year":"2000","unstructured":"Lee VH (2000) Membrane transporters. Eur J Pharm Sci 11 [Suppl 2]:S41\u2013S50","journal-title":"Eur J Pharm Sci"},{"key":"12_CR21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.2042-7158.1997.tb06084.x","volume":"49","author":"H Lennernas","year":"1997","unstructured":"Lennernas H (1997) Human jejunal effective permeability and its correlation with preclinical drug absorption models. J Pharm Pharmacol 49:627\u2013638","journal-title":"J Pharm Pharmacol"},{"key":"12_CR22","first-page":"5002","volume":"61","author":"YP Lu","year":"2001","unstructured":"Lu YP, Lou YR, Lin Y, Shih WJ, Huang MT, Yang CS, Conney AH (2001) Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. Cancer Res 61:5002\u20135009","journal-title":"Cancer Res"},{"key":"12_CR23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0024-3205(02)02236-1","volume":"72","author":"HL Lung","year":"2002","unstructured":"Lung HL, Ip WK, Wong CK, Mak NK, Chen ZY, Leung KN (2002) Anti-proliferative and differentiation-inducing activities of the green tea catechin epigallocatechin-3-gallate (EGCG) on the human eosinophilic leukemia EoL-1 cell line. Life Sci 72:257\u2013268","journal-title":"Life Sci"},{"key":"12_CR24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s002100000223","volume":"361","author":"F Martel","year":"2000","unstructured":"Martel F, Calhau C, Azevedo I (2000) Characterization of the transport of the organic cation [3H]-MPP+ in human intestinal epithelial (Caco-2) cells. Naunyn-Schmiedebergs Arch Pharmacol 361:505\u2013513","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"12_CR25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s002100000335","volume":"363","author":"F Martel","year":"2001","unstructured":"Martel F, Gr\u00fcndemann D, Calhau C, Sch\u00f6mig E (2001) Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters. Naunyn-Schmiedebergs Arch Pharmacol 363:40\u201349","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"12_CR26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-2999(85)90201-8","volume":"116","author":"E Melamed","year":"1985","unstructured":"Melamed E, Rosenthal J, Cohen O, Globus M, Uzzan A (1985) Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP. Eur J Pharmacol 116:179\u2013181","journal-title":"Eur J Pharmacol"},{"key":"12_CR27","first-page":"111","volume":"110","author":"J Michaud","year":"1079","unstructured":"Michaud J, Lacaze P, Masquelier J (1971) Fractionnement des oligom\u00e8res flavanoliques du raisin. Bull Soc Phar Bordeaux 110:111\u2013116","journal-title":"Bull Soc Phar Bordeaux"},{"key":"12_CR28","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.lfs.2004.12.008","volume":"75","author":"R Monteiro","year":"2005","unstructured":"Monteiro R, Calhau C, Guedes de Pinho P, Azevedo I (2005) Intestinal uptake of MPP+ is differently affected by red and white wine. Life Sci 75:2483\u20132496","journal-title":"Life Sci"},{"issue":"6 Suppl","key":"12_CR29","doi-asserted-by":"crossref","first-page":"1698S","DOI":"10.1093\/ajcn\/71.6.1698S","volume":"71","author":"H Mukhtar","year":"2000","unstructured":"Mukhtar H, Ahmad N (2000) Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 71(6 Suppl):1698S\u20131702S","journal-title":"Am J Clin Nutr"},{"key":"12_CR30","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1021\/jf981316h","volume":"48","author":"JB Paquay","year":"2000","unstructured":"Paquay JB, Haenen GR, Stender G, Wiseman SA, Tijburg LB, Bast A (2000) Protection against nitric oxide toxicity by tea. J Agric Food Chem 48:5768\u20135772","journal-title":"J Agric Food Chem"},{"key":"12_CR31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0378-4274(89)90168-9","volume":"48","author":"LM Sayre","year":"1989","unstructured":"Sayre LM (1989) Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol Lett 48:121\u2013149","journal-title":"Toxicol Lett"},{"key":"12_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1753-4887.2000.tb01818.x","volume":"58","author":"SI Trevisanato","year":"2000","unstructured":"Trevisanato SI, Kim YI (2000) Tea and health. Nutr Rev 58:1\u201310","journal-title":"Nutr Rev"},{"issue":"Suppl 1","key":"12_CR33","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0169-409X(01)00183-1","volume":"50","author":"D Wagner","year":"2001","unstructured":"Wagner D, Spahn-Langguth H, Hanafy A, Koggel A, Langguth P (2001) Intestinal drug efflux: formulation and food effects. Adv Drug Deliv Rev 50 [Suppl 1]:S13\u2013S31","journal-title":"Adv Drug Deliv Rev"},{"key":"12_CR34","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/jn\/130.10.2409","volume":"130","author":"CS Yang","year":"2000","unstructured":"Yang CS, Landau JM (2000) Effects of tea consumption on nutrition and health. J Nutr 130:2409\u20132412","journal-title":"J Nutr"},{"issue":"2S Suppl","key":"12_CR35","doi-asserted-by":"crossref","first-page":"472S","DOI":"10.1093\/jn\/130.2.472S","volume":"130","author":"CS Yang","year":"2000","unstructured":"Yang CS, Chung JY, Yang G, Chhabra SK, Lee MJ (2000) Tea and tea polyphenols in cancer prevention. J Nutr 130[2S Suppl]:472S\u2013478S","journal-title":"J Nutr"},{"key":"12_CR36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.pharmtox.42.082101.154309","volume":"42","author":"CS Yang","year":"2002","unstructured":"Yang CS, Maliakal P, Meng X (2002) Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42:25\u201354","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"12_CR37","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1023\/A:1012102522787","volume":"14","author":"S Yee","year":"1997","unstructured":"Yee S (1997) In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man\u2014fact or myth. Pharmacol Res 14:763\u2013766","journal-title":"Pharmacol Res"},{"key":"12_CR38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.pharmtox.38.1.431","volume":"38","author":"L Zhang","year":"1998","unstructured":"Zhang L, Brett CM, Giacomini KM (1998) Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol 38:431\u2013460","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"12_CR39","first-page":"713","volume":"11","author":"M Zhang","year":"2002","unstructured":"Zhang M, Binns CW, Lee AH (2002) Tea consumption and ovarian cancer risk: a case-control study in China. Cancer Epidemiol Biomarkers Prev 11:713\u2013718","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-005-0012-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-005-0012-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-005-0012-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T16:02:02Z","timestamp":1558627322000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-005-0012-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["12"],"URL":"https:\/\/doi.org\/10.1007\/s00210-005-0012-7","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}