{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:14:26Z","timestamp":1773890066274,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/68716\/2010"],"award-info":[{"award-number":["SFRH\/BPD\/68716\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PFD Research Foundation and ICA IC\/BPS Research Grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s00210-017-1384-1","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T02:16:22Z","timestamp":1496196982000},"page":"839-844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation"],"prefix":"10.1007","volume":"390","author":[{"given":"Rita","family":"Matos","sequence":"first","affiliation":[]},{"given":"Paula","family":"Serr\u00e3o","sequence":"additional","affiliation":[]},{"given":"Larissa","family":"Rodriguez","sequence":"additional","affiliation":[]},{"given":"Lori Ann","family":"Birder","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Cruz","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-7790","authenticated-orcid":false,"given":"Ana","family":"Charrua","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"1384_CR1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/nau.21078","volume":"30","author":"DE Bjorling","year":"2011","unstructured":"Bjorling DE, Wang ZY, Bushman W (2011) Models of inflammation of the lower urinary tract. Neurourol Urodyn 30:673\u2013682","journal-title":"Neurourol Urodyn"},{"key":"1384_CR2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-5347(05)67495-2","volume":"164","author":"M Boucher","year":"2000","unstructured":"Boucher M, Meen M, Codron JP, Coudore F, Kemeny JL, Eschalier A (2000) Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain. J Urol 164:203\u2013208","journal-title":"J Urol"},{"key":"1384_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01.ju.0000145891.35810.56","volume":"173","author":"S Cetinel","year":"2005","unstructured":"Cetinel S, Ercan F, Cikler E, Contuk G, Sener G (2005) Protective effect of melatonin on water avoidance stress induced degeneration of the bladder. J Urol 173:267\u2013270","journal-title":"J Urol"},{"key":"1384_CR4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/nau.22542","volume":"34","author":"A Charrua","year":"2015","unstructured":"Charrua A, Pinto R, Taylor A, Canelas A, Ribeiro-da-silva A, Cruz CD, Birder LA, Cruz F (2015) Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome\/interstitial cystitis? A clinical and experimental study. Neurourol Urodyn 34:489\u2013496","journal-title":"Neurourol Urodyn"},{"key":"1384_CR5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.urology.2013.11.013","volume":"83","author":"MS Choo","year":"2014","unstructured":"Choo MS, Song M, Kim JH, Lee KS, Kim JC, Kim SW, Yang SK, Lee JG, Lee JZ, Kim DK, Park WH, Kim KD, Na YG, Kwon DD, Paick JS (2014) Safety and efficacy of 8-mg once-daily vs 4-mg twice-daily silodosin in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (SILVER study): a 12-week, double-blind, randomized, parallel, multicenter study. Urology 83:875\u2013881","journal-title":"Urology"},{"key":"1384_CR6","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/0006-2952(79)90222-3","volume":"28","author":"PJ Cox","year":"1979","unstructured":"Cox PJ (1979) Cyclophosphamide cystitis\u2014identification of acrolein as the causative agent. Biochem Pharmacol 28:2045\u20132049","journal-title":"Biochem Pharmacol"},{"key":"1384_CR7","volume-title":"TRP channels in drug discovery","author":"CD Cruz","year":"2012","unstructured":"Cruz CD, Avelino A (2012) Animal models of cystitis. In: Szallasi A, Bir\u00f3 T (eds) TRP channels in drug discovery. Humana Press, New York City"},{"key":"1384_CR8","first-page":"263","volume":"65","author":"S Diniz","year":"2013","unstructured":"Diniz S, Dinis P, Cruz F, Pinto R (2013) Bladder pain syndrome\/interstitial cystitis: present and future treatment perspectives. Minerva Urol Nefrol 65:263\u2013276","journal-title":"Minerva Urol Nefrol"},{"key":"1384_CR9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-444-53491-0.00024-9","volume":"117","author":"PD Drummond","year":"2013","unstructured":"Drummond PD (2013) Sensory-autonomic interactions in health and disease. Handb Clin Neurol 117:309\u2013319","journal-title":"Handb Clin Neurol"},{"key":"1384_CR10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00345-013-1228-7","volume":"32","author":"A Eisenhardt","year":"2014","unstructured":"Eisenhardt A, Schneider T, Cruz F, Oelke M (2014) Consistent and significant improvement of nighttime voiding frequency (nocturia) with silodosin in men with LUTS suggestive of BPH: pooled analysis of three randomized, placebo-controlled, double-blind phase III studies. World J Urol 32:1119\u20131125","journal-title":"World J Urol"},{"key":"1384_CR11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00005392-200101000-00070","volume":"165","author":"F Ercan","year":"2001","unstructured":"Ercan F, Oktay S, Erin N (2001) Role of afferent neurons in stress induced degenerative changes of the bladder. J Urol 165:235\u2013239","journal-title":"J Urol"},{"key":"1384_CR12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/nau.22921","volume":"36","author":"G Felde","year":"2017","unstructured":"Felde G, Ebbesen MH, Hunskaar S (2017) Anxiety and depression associated with urinary incontinence. A 10-year follow-up study from the Norwegian HUNT study (EPINCONT). Neurourol Urodyn 36:322\u2013328","journal-title":"Neurourol Urodyn"},{"key":"1384_CR13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0090-4295(01)01044-5","volume":"57","author":"MO Fraser","year":"2001","unstructured":"Fraser MO, Chuang YC, Lavelle JP, Yoshimura N, De Groat WC, Chancellor MB (2001) A reliable, nondestructive animal model for interstitial cystitis: intravesical low-dose protamine sulfate combined with physiological concentrations of potassium chloride. Urology 57:112","journal-title":"Urology"},{"key":"1384_CR14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1053\/j.gastro.2010.11.003","volume":"140","author":"S Hong","year":"2011","unstructured":"Hong S, Zheng G, Wu X, Snider NT, Owyang C, Wiley JW (2011) Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat. Gastroenterology 140:627\u2013637 e4","journal-title":"Gastroenterology"},{"key":"1384_CR15","first-page":"865463","volume":"2014","author":"SK Keay","year":"2014","unstructured":"Keay SK, Birder LA, Chai TC (2014) Evidence for bladder urothelial pathophysiology in functional bladder disorders. Biomed Res Int 2014:865463\u2013865478","journal-title":"Biomed Res Int"},{"key":"1384_CR16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12894-015-0009-6","volume":"15","author":"H Lai","year":"2015","unstructured":"Lai H, Gardner V, Vetter J, Andriole GL (2015) Correlation between psychological stress levels and the severity of overactive bladder symptoms. BMC Urol 15:14\u201320","journal-title":"BMC Urol"},{"key":"1384_CR17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0304-3959(01)00275-5","volume":"92","author":"JM Laird","year":"2001","unstructured":"Laird JM, Martinez-Caro L, Garcia-Nicas E, Cervero F (2001) A new model of visceral pain and referred hyperalgesia in the mouse. Pain 92:335\u2013342","journal-title":"Pain"},{"key":"1384_CR18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.physbeh.2014.11.045","volume":"139","author":"UJ Lee","year":"2015","unstructured":"Lee UJ, Ackerman AL, Wu A, Zhang R, Leung J, Bradesi S, Mayer EA, Rodriguez LV (2015) Chronic psychological stress in high-anxiety rats induces sustained bladder hyperalgesia. Physiol Behav 139:541\u2013548","journal-title":"Physiol Behav"},{"key":"1384_CR19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0022-5347(05)67152-2","volume":"164","author":"SK Lutgendorf","year":"2000","unstructured":"Lutgendorf SK, Kreder KJ, Rothrock NE, Ratliff TL, Zimmerman B (2000) Stress and symptomatology in patients with interstitial cystitis: a laboratory stress model. J Urol 164:1265\u20131269","journal-title":"J Urol"},{"key":"1384_CR20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/apha.12744","volume":"218","author":"R Matos","year":"2016","unstructured":"Matos R, Cordeiro JM, Coelho A, Ferreira S, Silva C, Igawa Y, Cruz F, Charrua A (2016) Bladder pain induced by prolonged peripheral alpha 1A adrenoceptor stimulation involves the enhancement of transient receptor potential vanilloid 1 activity and an increase of urothelial adenosine triphosphate release. Acta Physiol (Oxf) 218:265\u2013275","journal-title":"Acta Physiol (Oxf)"},{"key":"1384_CR21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.juro.2011.03.028","volume":"186","author":"JC Nickel","year":"2011","unstructured":"Nickel JC, O'Leary MP, Lepor H, Caramelli KE, Thomas H, Hill LA, Hoel GE (2011) Silodosin for men with chronic prostatitis\/chronic pelvic pain syndrome: results of a phase II multicenter, double-blind, placebo controlled study. J Urol 186:125\u2013131","journal-title":"J Urol"},{"key":"1384_CR22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/bs.pmbts.2014.11.009","volume":"131","author":"AN Pierce","year":"2015","unstructured":"Pierce AN, Christianson JA (2015) Stress and chronic pelvic pain. Prog Mol Biol Transl Sci 131:509\u2013535","journal-title":"Prog Mol Biol Transl Sci"},{"key":"1384_CR23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0090-4295(00)00988-2","volume":"57","author":"NE Rothrock","year":"2001","unstructured":"Rothrock NE, Lutgendorf SK, Kreder KJ, Ratliff T, Zimmerman B (2001) Stress and symptoms in patients with interstitial cystitis: a life stress model. Urology 57:422\u2013427","journal-title":"Urology"},{"key":"1384_CR24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12017-007-8018-6","volume":"10","author":"T Schlereth","year":"2008","unstructured":"Schlereth T, Birklein F (2008) The sympathetic nervous system and pain. NeuroMolecular Med 10:141\u2013147","journal-title":"NeuroMolecular Med"},{"key":"1384_CR25","first-page":"5","volume":"1","author":"H Shah","year":"2011","unstructured":"Shah H (2011) How to calculate sample size in animal studies? Natl J Physiol Pharm Pharmacol 1:5","journal-title":"Natl J Physiol Pharm Pharmacol"},{"issue":"967","key":"1384_CR26","first-page":"e1","volume":"78","author":"AL Smith","year":"2011","unstructured":"Smith AL, Leung J, Kun S, Zhang R, Karagiannides I, Raz S, Lee U, Glovatscka V, Pothoulakis C, Bradesi S, Mayer EA, Rodriguez LV (2011) The effects of acute and chronic psychological stress on bladder function in a rodent model. Urology 78(967):e1\u2013e7","journal-title":"Urology"},{"key":"1384_CR27","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/j.1476-5381.1995.tb13362.x","volume":"114","author":"P Soares-da-Silva","year":"1995","unstructured":"Soares-da-Silva P, Pestana M, Vieira-Coelho MA, Fernandes MH, Albino-Teixeira A (1995) Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model. Br J Pharmacol 114:1403\u20131413","journal-title":"Br J Pharmacol"},{"key":"1384_CR28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0022-5347(01)65247-9","volume":"157","author":"C Spanos","year":"1997","unstructured":"Spanos C, Pang X, Ligris K, Letourneau R, Alferes L, Alexacos N, Sant GR, Theoharides TC (1997) Stress-induced bladder mast cell activation: implications for interstitial cystitis. J Urol 157:669\u2013672","journal-title":"J Urol"},{"key":"1384_CR29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0022-3999(87)90070-5","volume":"31","author":"A Steptoe","year":"1987","unstructured":"Steptoe A (1987) The assessment of sympathetic nervous function in human stress research. J Psychosom Res 31:141\u2013152","journal-title":"J Psychosom Res"},{"key":"1384_CR30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.eururo.2007.01.016","volume":"52","author":"M Trevisani","year":"2007","unstructured":"Trevisani M, Campi B, Gatti R, Andre E, Materazzi S, Nicoletti P, Gazzieri D, Geppetti P (2007) The influence of alpha1-adrenoreceptors on neuropeptide release from primary sensory neurons of the lower urinary tract. Eur Urol 52:901\u2013908","journal-title":"Eur Urol"},{"key":"1384_CR31","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.juro.2009.01.025","volume":"181","author":"C Twiss","year":"2009","unstructured":"Twiss C, Kilpatrick L, Craske M, Buffington CA, Ornitz E, Rodriguez LV, Mayer EA, Naliboff BD (2009) Increased startle responses in interstitial cystitis: evidence for central hyperresponsiveness to visceral related threat. J Urol 181:2127\u20132133","journal-title":"J Urol"},{"key":"1384_CR32","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1248\/bpb.34.1240","volume":"34","author":"Y Zhou","year":"2011","unstructured":"Zhou Y, Sun PH, Liu YW, Zhao X, Meng L, Cui YM (2011) Safety and pharmacokinetic studies of silodosin, a new alpha1A-adrenoceptor selective antagonist, in healthy Chinese male subjects. Biol Pharm Bull 34:1240\u20131245","journal-title":"Biol Pharm Bull"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-017-1384-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-017-1384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-017-1384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T06:09:01Z","timestamp":1499926141000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-017-1384-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,31]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["1384"],"URL":"https:\/\/doi.org\/10.1007\/s00210-017-1384-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,31]]}}}