{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:47:25Z","timestamp":1777492045643,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T00:00:00Z","timestamp":1357948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s00216-012-6695-y","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T07:46:51Z","timestamp":1357890411000},"page":"3953-3963","source":"Crossref","is-referenced-by-count":74,"title":["Determination of seven selected antipsychotic drugs in human plasma using microextraction in packed sorbent and gas chromatography\u2013tandem mass spectrometry"],"prefix":"10.1007","volume":"405","author":[{"given":"B. M.","family":"da Fonseca","sequence":"first","affiliation":[]},{"given":"I. E. D.","family":"Moreno","sequence":"additional","affiliation":[]},{"given":"M.","family":"Barroso","sequence":"additional","affiliation":[]},{"given":"S.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"J. A.","family":"Queiroz","sequence":"additional","affiliation":[]},{"given":"E.","family":"Gallardo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,1,12]]},"reference":[{"key":"6695_CR1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jcla.20345","volume":"23","author":"LV Rao","year":"2009","unstructured":"Rao LV, Snyder ML, Vallaro GM (2009) Rapid liquid chromatography\/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (Norclozapine) in human serum. J Clin Lab Anal 23:394\u2013398","journal-title":"J Clin Lab Anal"},{"key":"6695_CR2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jms.1783","volume":"45","author":"E Saar","year":"2010","unstructured":"Saar E, Gerostamoulos D, Drummer OH, Beyer J (2010) Identification and quantification of 30 antipsychotics in blood using LC-MS\/MS. J Mass Spectrom 45:915\u2013925","journal-title":"J Mass Spectrom"},{"key":"6695_CR3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/bmc.997","volume":"22","author":"G Zhang","year":"2008","unstructured":"Zhang G, Terry AV Jr, Bartlett MG (2008) Bioanalytical methods for the determination of antipsychotic drugs. Biomed Chromatogr 22:671\u2013687","journal-title":"Biomed Chromatogr"},{"key":"6695_CR4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jchromb.2007.05.015","volume":"856","author":"G Zhang","year":"2007","unstructured":"Zhang G, Terry AV Jr, Bartlett MG (2007) Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection. J Chromatogr B 856:20\u201328","journal-title":"J Chromatogr B"},{"key":"6695_CR5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00216-007-1195-1","volume":"388","author":"L Mercolini","year":"2007","unstructured":"Mercolini L, Grillo M, Bartoletti C, Boncompagni G, Raggi MA (2007) Simultaneous analysis of classical neuroleptics, atypical antipsychotics and their metabolites in human plasma. Anal Bioanal Chem 388:235\u2013243","journal-title":"Anal Bioanal Chem"},{"key":"6695_CR6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jchromb.2006.09.019","volume":"846","author":"L Mercolini","year":"2007","unstructured":"Mercolini L, Bugamelli F, Kenndler E, Boncompagni G, Franchini L, Raggi MA (2007) Simultaneous determination of the antipsychotic drugs levomepromazine and clozapine and their main metabolites in human plasma by a HPLC-UV method with solid-phase extraction. J Chromatogr B 846:273\u2013280","journal-title":"J Chromatogr B"},{"key":"6695_CR7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jpba.2005.10.050","volume":"41","author":"P Cutroneo","year":"2006","unstructured":"Cutroneo P, Beljean M, Luu RP, Siouffi AM (2006) Optimization of the separation of some psychotropic drugs and their respective metabolites by liquid chromatography. J Pharm Biomed Anal 41:333\u2013340","journal-title":"J Pharm Biomed Anal"},{"key":"6695_CR8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jssc.201000649","volume":"34","author":"S Bazhdanzadeh","year":"2011","unstructured":"Bazhdanzadeh S, Talebpour Z, Adib N, Aboul-Enein HY (2011) A simple and reliable stir bar sorptive extraction-liquid chromatography procedure for the determination of chlorpromazine and trifluoperazine in human serum using experimental design methodology. J Sep Sci 34:90\u201397","journal-title":"J Sep Sci"},{"key":"6695_CR9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jchromb.2006.05.031","volume":"843","author":"H Kirchherr","year":"2006","unstructured":"Kirchherr H, K\u00fchn-Velten WN (2006) Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. J Chromatogr B 843:100\u2013113","journal-title":"J Chromatogr B"},{"key":"6695_CR10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.forsciint.2004.12.007","volume":"155","author":"C Torre de la","year":"2005","unstructured":"de la Torre C, Mart\u00ednez MA, Almarza E (2005) Determination of several psychiatric drugs in whole blood using capillary gas\u2013liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures. Forensic Sci Int 155:193\u2013204","journal-title":"Forensic Sci Int"},{"key":"6695_CR11","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.jchromb.2010.07.001","volume":"878","author":"I Vardakou","year":"2010","unstructured":"Vardakou I, Dona A, Pistos C, Alevisopoulos G, Athanaselis S, Maravelias C, Spiliopoulou C (2010) Validated GC\/MS method for the simultaneous determination of clozapine and norclozapine in human plasma. Application in psychiatric patients under clozapine treatment. J Chromatogr B 878:2327\u20132332","journal-title":"J Chromatogr B"},{"key":"6695_CR12","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.chroma.2011.01.071","volume":"1218","author":"MA Saracino","year":"2011","unstructured":"Saracino MA, Lazzara G, Prugnoli B, Raggi MA (2011) Rapid assays of clozapine and its metabolites in dried blood spots by liquid chromatography and microextraction by packed sorbent procedure. J Chromatogr A 1218:2153\u20132159","journal-title":"J Chromatogr A"},{"key":"6695_CR13","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jpba.2009.07.007","volume":"50","author":"E Choong","year":"2009","unstructured":"Choong E, Rudaz S, Kottelat A, Guillarme D, Veuthey JL, Eap CB (2009) Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS. J Pharm Biomed Anal 50:1000\u20131008","journal-title":"J Pharm Biomed Anal"},{"key":"6695_CR14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jchromb.2010.11.024","volume":"879","author":"J Hasselstr\u00f8m","year":"2011","unstructured":"Hasselstr\u00f8m J (2011) Quantification of antidepressants and antipsychotics in human serum by precipitation and ultra high pressure liquid chromatography\u2013tandem mass spectrometry. J Chromatogr B 879:123\u2013128","journal-title":"J Chromatogr B"},{"key":"6695_CR15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jchromb.2007.04.004","volume":"854","author":"E Tanaka","year":"2007","unstructured":"Tanaka E, Nakamura T, Terada M, Shinozuka T, Hashimoto C, Kurihara K, Honda K (2007) Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography. J Chromatogr B 854:116\u2013120","journal-title":"J Chromatogr B"},{"key":"6695_CR16","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1080\/03639040701484338","volume":"33","author":"M Rosland","year":"2007","unstructured":"Rosland M, Szeto P, Procyshyn R, Barr AM, Wasan KM (2007) Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography. Drug Dev Ind Pharm 33:1158\u20131166","journal-title":"Drug Dev Ind Pharm"},{"key":"6695_CR17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jchromb.2005.11.032","volume":"830","author":"J Sachse","year":"2006","unstructured":"Sachse J, K\u00f6ller J, H\u00e4rtter S, Hiemke C (2006) Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection. J Chromatogr B 830:342\u2013348","journal-title":"J Chromatogr B"},{"key":"6695_CR18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aca.2006.05.067","volume":"575","author":"J Li","year":"2006","unstructured":"Li J, Zhao F, Ju H (2006) Simultaneous determination of psychotropic drugs in human urine by capillary electrophoresis with electrochemiluminescence detection. Anal Chim Acta 575:57\u201361","journal-title":"Anal Chim Acta"},{"key":"6695_CR19","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1002\/elps.200500098","volume":"26","author":"FJ Lara","year":"2005","unstructured":"Lara FJ, Garc\u00eda-Campa\u00f1a AM, Al\u00e9s-Barrero F, Bosque-Sendra JM (2005) Development and validation of a capillary electrophoresis method for the determination of phenothiazines in human urine in the low nanogram per milliliter concentration range using field-amplified sample injection. Electrophoresis 26:2418\u20132429","journal-title":"Electrophoresis"},{"key":"6695_CR20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/dta.1337","volume":"4","author":"E Saar","year":"2012","unstructured":"Saar E, Beyer J, Gerostamoulos D, Drummer OH (2012) The analysis of antipsychotic drugs in human matrices using LC-MS(\/MS). Drug Test Anal 4:376\u2013394","journal-title":"Drug Test Anal"},{"key":"6695_CR21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jchromb.2007.08.007","volume":"858","author":"G Zhang","year":"2007","unstructured":"Zhang G, Terry AV Jr, Bartlett MG (2007) Sensitive liquid chromatography\/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. J Chromatogr B 858:276\u2013281","journal-title":"J Chromatogr B"},{"key":"6695_CR22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jchromb.2007.03.045","volume":"854","author":"G Zhang","year":"2007","unstructured":"Zhang G, Terry AV Jr, Bartlett MG (2007) Sensitive liquid chromatography\/tandem mass spectrometry method for the determination of the lipophilic antipsychotic drug chlorpromazine in rat plasma and brain tissue. J Chromatogr B 854:68\u201376","journal-title":"J Chromatogr B"},{"key":"6695_CR23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jchromb.2006.02.042","volume":"834","author":"HA Niederl\u00e4nder","year":"2006","unstructured":"Niederl\u00e4nder HA, Koster EH, Hilhorst MJ, Metting HJ, Eilders M, Ooms B, de Jong GJ (2006) High throughput therapeutic drug monitoring of clozapine and metabolites in serum by on-line coupling of solid phase extraction with liquid chromatography\u2013mass spectrometry. J Chromatogr B 834:98\u2013107","journal-title":"J Chromatogr B"},{"key":"6695_CR24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chroma.2007.01.137","volume":"1160","author":"A Castro de","year":"2007","unstructured":"de Castro A, Fernandez MMR, Laloup M, Samyn N, Boeck G, Wood M, Maes V, L\u00f3pez-Rivadulla M (2007) High-throughput on-line solid-phase extraction\u2013liquid chromatography\u2013tandem mass spectrometry method for the simultaneous analysis of 14 antidepressants and their metabolites in plasma. J Chromatogr A 1160:3\u201312","journal-title":"J Chromatogr A"},{"key":"6695_CR25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpba.2011.12.004","volume":"61","author":"IED Moreno","year":"2012","unstructured":"Moreno IED, da Fonseca BM, Barroso M, Costa S, Queiroz JA, Gallardo E (2012) Determination of piperazine-type stimulants in human urine by means of microextraction in packed sorbent and high performance liquid chromatography\u2013diode array detection. J Pharm Biomed Anal 61:93\u201399","journal-title":"J Pharm Biomed Anal"},{"key":"6695_CR26","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1016\/j.chroma.2009.02.093","volume":"1216","author":"H Miyaguchi","year":"2009","unstructured":"Miyaguchi H, Iwata Y, Kanamori T, Tsujikawa K, Kuwayama K, Inoue H (2009) Rapid identification and quantification of methamphetamine and amphetamine in hair by gas chromatography\/mass spectrometry coupled with micropulverized extraction, aqueous acetylation and microextraction by packed sorbent. J Chromatogr A 1216:4063\u20134070","journal-title":"J Chromatogr A"},{"key":"6695_CR27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.chroma.2011.12.016","volume":"1222","author":"IED Moreno","year":"2012","unstructured":"Moreno IED, da Fonseca BM, Magalh\u00e3es AR, Geraldes VS, Queiroz JA, Barroso M, Costa S, Gallardo E (2012) Rapid determination of piperazine-type stimulants in human urine by microextraction in packed sorbent after method optimization using a multivariate approach. J Chromatogr A 1222:116\u2013120","journal-title":"J Chromatogr A"},{"key":"6695_CR28","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/jms.731","volume":"39","author":"M Abdel-Rehim","year":"2004","unstructured":"Abdel-Rehim M, Altun Z, Blomberg L (2004) Microextraction in packed syringe (MEPS) for liquid and gas chromatographic applications. Part II\u2014determination of ropivacaine and its metabolites in human plasma samples using MEPS with liquid chromatography\/tandem mass spectrometry. J Mass Spectrom 39:1488\u20131493","journal-title":"J Mass Spectrom"},{"key":"6695_CR29","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.chroma.2009.09.053","volume":"1217","author":"M Abdel-Rehim","year":"2010","unstructured":"Abdel-Rehim M (2010) Recent advances in microextraction by packed sorbent for bioanalysis. J Chromatogr A 1217:2569\u20132580","journal-title":"J Chromatogr A"},{"key":"6695_CR30","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.jchromb.2010.06.023","volume":"878","author":"A Chaves","year":"2010","unstructured":"Chaves A, Leandro F, Carris J, Queiroz ME (2010) Microextraction in packed sorbent for analysis of antidepressants in human plasma by liquid chromatography and spectrophotometric detection. J Chromatogr B 878:2123\u20132129","journal-title":"J Chromatogr B"},{"key":"6695_CR31","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.talanta.2010.02.067","volume":"81","author":"MA Saracino","year":"2010","unstructured":"Saracino MA, de Palma A, Boncompagni G, Raggi MA (2010) Analysis of risperidone and its metabolite in plasma and saliva by LC with coulometric detection and a novel MEPS procedure. Talanta 81:1547\u20131553","journal-title":"Talanta"},{"key":"6695_CR32","unstructured":"International Conference on Harmonization (ICH), Validation of Analytical Procedures: Methodology ICH Q2 B. (2005). Available from http:\/\/www.ich.org\/LOB\/media\/MEDIA417.pdf . Accessed 29 November 2011"},{"key":"6695_CR33","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation (2001). Available from http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceCompilanceRegulatoryInformation\/Guidances\/ucm070107.pdf . Accessed 29 November 2011"},{"key":"6695_CR34","unstructured":"World Anti-doping Agency, International standard for laboratories: identification criteria for qualitative assays incorporating column chromatography and mass spectrometry (2010). Available from http:\/\/www.wadaama.org\/Documents\/World_AntiDoping_Program\/WADP-IS-Laboratories\/WADA_TD2010IDCRv1.0_IdentificationCriteriaforQualitativeAssays_May082010_EN.doc.pdf . Accessed 3 January 2012"},{"key":"6695_CR35","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1016\/j.chroma.2010.08.001","volume":"1217","author":"M Barroso","year":"2010","unstructured":"Barroso M, Costa S, Dias M, Vieira DN, Queiroz JA, L\u00f3pez-Rivadulla M (2010) Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography\u2013mass spectrometry. J Chromatogr A 1217:6274\u20136280","journal-title":"J Chromatogr A"},{"key":"6695_CR36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.forsciint.2012.01.029","volume":"220","author":"E Saar","year":"2012","unstructured":"Saar E, Gerostamoulos D, Drummer OH, Beyer J (2012) Identification of 2-hydroxymethyl-olanzapine as a novel degradation product of olanzapine. Forensic Sci Int 220:74\u201379","journal-title":"Forensic Sci Int"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-012-6695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-012-6695-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-012-6695-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T17:15:25Z","timestamp":1558631725000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-012-6695-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,12]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["6695"],"URL":"https:\/\/doi.org\/10.1007\/s00216-012-6695-y","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,12]]}}}