{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:37:00Z","timestamp":1773293820692,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T00:00:00Z","timestamp":1272412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Food Res Technol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00217-010-1281-z","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T08:58:46Z","timestamp":1272358726000},"page":"339-346","source":"Crossref","is-referenced-by-count":22,"title":["Optimization of the culture medium composition using response surface methodology for new recombinant cyprosin B production in bioreactor for cheese production"],"prefix":"10.1007","volume":"231","author":[{"given":"Pedro N.","family":"Sampaio","sequence":"first","affiliation":[]},{"given":"Cec\u00edlia R. C.","family":"Calado","sequence":"additional","affiliation":[]},{"given":"Lisete","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"David C.","family":"Bressler","sequence":"additional","affiliation":[]},{"given":"Maria Salom\u00e9","family":"Pais","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds Pina","family":"Fonseca","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,4,28]]},"reference":[{"key":"1281_CR1","first-page":"683","volume":"47","author":"MC Cordeiro","year":"1992","unstructured":"Cordeiro MC, Jacob E, Kuhn Z, Pais MS, Brodelius PE (1992) Milk clotting and proteolytic activities of purified cynarases from Cynara cardunculus\u2013a comparison to chymosin. Milchwissenschaft 47:683\u2013687","journal-title":"Milchwissenschaft"},{"key":"1281_CR2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/BF00029855","volume":"24","author":"MC Cordeiro","year":"1994","unstructured":"Cordeiro MC, Xue ZT, Pietrzak M, Pais MS, Brodelius PE (1994) Isolation and characterization of a cDNA from flowers of Cynara cardunculus encoding cyprosin (an aspartic proteinase) and its use to study the organ-specific expression of cyprosin. Plant Mol Biol 24:733\u2013741","journal-title":"Plant Mol Biol"},{"key":"1281_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1263\/jbb.105.305","volume":"105","author":"PN Sampaio","year":"2008","unstructured":"Sampaio PN, Fortes AM, Cabral JMS, Pais MS, Fonseca LP (2008) Production and characterization of recombinant cyprosin B in Saccharomyces cerevisiae (W303\u20131A) strain. J Biosc Bioeng 105:305\u2013312. doi: 10.1263\/JBB.105.305","journal-title":"J Biosc Bioeng"},{"key":"1281_CR4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/fgbi.2000.1241","volume":"31","author":"RJ Swift","year":"2000","unstructured":"Swift RJ, Karandikar A, Griffen AM, Punt PJ, Cees AMJJ, Hondel VD, Robson GD, Trinci APJ, Wiebe MG (2000) The effect of organic nitrogen sources on recombinant glucoamylase production by Aspergillus niger in chemostat culture. Fungal Gen Biol 31:125\u2013133. doi: 10.1006\/fgbi.2000.1241","journal-title":"Fungal Gen Biol"},{"key":"1281_CR5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1046\/j.1472-765X.2003.01313.x","volume":"36","author":"IU Haq","year":"2003","unstructured":"Haq IU, Ali S, Iqbal J (2003) Effects of volume of culture medium on enhanced citric acid productivity by a mutant culture of Aspergillus n\u00edger in stirred fermenter. Lett Appl Microbiol 36:302\u2013306","journal-title":"Lett Appl Microbiol"},{"key":"1281_CR6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S1389-1723(02)80067-6","volume":"93","author":"CR Calado","year":"2002","unstructured":"Calado CR, Monteiro SM, Cabral JM, Fonseca LP (2002) Effect of pre-fermentation on the production of cutinase by a recombinant Saccharomyces cerevisiae. J Biosc Bioeng 93:354\u2013359","journal-title":"J Biosc Bioeng"},{"key":"1281_CR7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1023\/A:1010338904870","volume":"23","author":"ALS Schneider","year":"2001","unstructured":"Schneider ALS, Merkle R, Carvalho-Jonas MF, Jonas R, Furlan S (2001) Oxygen transfer on \u03b2-D-galactosidase production by Kluyveromyces marxianus using sugar cane molasses as carbon source. Biotechnol Lett 23:547\u2013550","journal-title":"Biotechnol Lett"},{"key":"1281_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.enzmictec.2003.07.004","volume":"34","author":"E Jurado","year":"2004","unstructured":"Jurado E, Camacho F, Luz\u00f3n G, Vicaria JM (2004) Kinetic models of activity for \u03b2-galactosidases: influence of pH, ionic concentration and temperature. Enz Microbial Technol 34:33\u201340","journal-title":"Enz Microbial Technol"},{"key":"1281_CR9","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.enzmictec.2006.08.016","volume":"40","author":"C Tari","year":"2007","unstructured":"Tari C, Gogus N, Tokatli F (2007) Optimization of biomass, pellet size and polygalacturonase production by Aspergillus sojae ATCC 20235 using response surface methodology. Enz Microbial Technol 40:1108\u20131116","journal-title":"Enz Microbial Technol"},{"key":"1281_CR10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1097-0290(19990705)64:1<92::AID-BIT10>3.0.CO;2-8","volume":"64","author":"LP Ooijkaas","year":"1999","unstructured":"Ooijkaas LP, Wilkinson EC, Tramper J, Buitelaar RM (1999) Medium optimization for spore production of Coniothyrium minitans using statistically-based experimental designs. Biotechnol Bioeng 64:92\u2013100","journal-title":"Biotechnol Bioeng"},{"key":"1281_CR11","first-page":"225","volume":"51","author":"YR Abdel-Fattah","year":"2002","unstructured":"Abdel-Fattah YR, Abdel-Fattah WR, Zamilpa R, Pierce JR (2002) Numerical modelling of ferrous-ion oxidation rate in Acidithiobacillus ferroxidans ATCC 23270: optimization of culture conditions through statistically designed experiments. Acta Microbiol Pol 51:225\u2013235","journal-title":"Acta Microbiol Pol"},{"key":"1281_CR12","first-page":"272","volume":"5","author":"K Adinarayana","year":"2002","unstructured":"Adinarayana K, Ellaiah P (2002) Response surface optimization of the critical medium components for the production of alkaline protease by a newly isolated Bacillus sp. J Pharm Sci 5:272\u2013278","journal-title":"J Pharm Sci"},{"key":"1281_CR13","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1023\/A:1024009027255","volume":"25","author":"C Liu","year":"2003","unstructured":"Liu C, Liu Y, Liao W, Wen Z, Chen S (2003) Application of statistically-based experimental designs for the optimization of nisin production from whey. Biotechnol Lett 25:877\u2013882","journal-title":"Biotechnol Lett"},{"key":"1281_CR14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1021\/bp980098+","volume":"14","author":"A Ismael","year":"1998","unstructured":"Ismael A, Soultani S, Ghoul M (1998) Optimization of the enzymatic synthesis of butyl glucoside using response surface methodology. Biotechnol Prog 14:874\u2013878","journal-title":"Biotechnol Prog"},{"key":"1281_CR15","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00253-002-0965-0","volume":"58","author":"YS Park","year":"2002","unstructured":"Park YS, Kang SW, Lee JS, Hong SI (2002) Xylanase production in solid state fermentation by Aspergillus niger mutant using statistical experimental designs. Appl Microbiol Biotechnol 58:761\u2013766","journal-title":"Appl Microbiol Biotechnol"},{"key":"1281_CR16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0960-8524(99)00140-6","volume":"73","author":"E Mubeccel","year":"2000","unstructured":"Mubeccel E, Mutlu SF (2000) Application of a statistical technique to the production of ethanol from sugar beet molasses by Saccharomyces cerevisiae. Biores Technol 73:251\u2013253","journal-title":"Biores Technol"},{"key":"1281_CR17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/yea.1399","volume":"23","author":"TE Oner","year":"2006","unstructured":"Oner TE (2006) Optimization of ethanol production from starch by an amylolytic nuclear petite Saccharomyces cerevisiae strain. Yeast 23:849\u2013856","journal-title":"Yeast"},{"key":"1281_CR18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s002530050930","volume":"47","author":"X Yu","year":"1997","unstructured":"Yu X, Hallet SG, Sheppard J, Watson AK (1997) Application of the Plackett-Burman experimental design to evaluate nutritional requirements for the production of Colletotrichum coccodes spores. Appl Microbiol Biotechnol 47:301\u2013305","journal-title":"Appl Microbiol Biotechnol"},{"key":"1281_CR19","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0032-9592(03)00232-2","volume":"39","author":"M Elibol","year":"2004","unstructured":"Elibol M (2004) Optimization of medium composition for actinorhodin production by Streptomyces coelicolor A3(2) with response surface methodology. Process Biochem 39:1057\u20131062","journal-title":"Process Biochem"},{"key":"1281_CR20","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/bit.20474","volume":"90","author":"R Gheshlaghi","year":"2005","unstructured":"Gheshlaghi R, Sharer JR, Moo-Young M, Douglas PL (2005) Medium optimization for hen egg white lysozyme production by recombinant Aspergillus niger using statistical methods. Biotechnol Bioeng 90:754\u2013760","journal-title":"Biotechnol Bioeng"},{"key":"1281_CR21","first-page":"639","volume":"35","author":"KJ Rao","year":"2004","unstructured":"Rao KJ, Kim C-H, Rhee S-K (2004) Statistical optimization of medium for the production of recombinant hirudin from Saccharomyces cerevisiae using response surface methodology. Process Biochem 35:639\u2013647","journal-title":"Process Biochem"},{"key":"1281_CR22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00253-006-0661-6","volume":"74","author":"G-Q Liu","year":"2007","unstructured":"Liu G-Q, Wang X-L (2007) Optimization of critical medium components using response surface methodology for biomass and extracellular polysaccharide production by Agaricus blazei. Appl Microbiol Biotecnol 74:78\u201383","journal-title":"Appl Microbiol Biotecnol"},{"key":"1281_CR23","volume-title":"Current protocols in molecular biology, cap. 13\u2013Saccharomyces cerevisiae","author":"FM Ausubel","year":"1997","unstructured":"Ausubel FM, Brent R, Kingston R, Moore DD, Seidenan JG, Smith JA, Struhl K (1997) Current protocols in molecular biology, cap. 13\u2013Saccharomyces cerevisiae. Wiley, USA"},{"key":"1281_CR24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1281_CR25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0003-2697(84)90553-0","volume":"143","author":"SS Twining","year":"1984","unstructured":"Twining SS (1984) Fluorescein isothiocyanate\u2013labeled casein assay for proteolytic enzymes. Anal Biochem 143:30\u201334","journal-title":"Anal Biochem"},{"key":"1281_CR26","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0031-9422(90)80090-4","volume":"29","author":"U Heimgartner","year":"1990","unstructured":"Heimgartner U, Pietrzak M, Geertsen R, Brodelius P, da Silva Figueiredo AC, Pais MS (1990) Purification and partial characterization of milk clotting proteases from flowers of Cynara cardunculus. Phytochemistry 29:1405\u20131410","journal-title":"Phytochemistry"},{"key":"1281_CR27","doi-asserted-by":"crossref","unstructured":"Berridge NJ (1987) Some observations on the determination of the activity of rennet. Norma FIL-IDF, 110-A. Analyst (London) 77:57\u201362","DOI":"10.1039\/an952770057b"},{"key":"1281_CR28","doi-asserted-by":"crossref","unstructured":"Box GEP, Wilson KB (1951) On the experimental attainment of optimum conditions. J Royal Stat Soc, B13, New York, USA","DOI":"10.1111\/j.2517-6161.1951.tb00067.x"},{"key":"1281_CR29","volume-title":"Response surfaces: design and analysis","author":"AI Khui","year":"1987","unstructured":"Khui AI, Cornell JA (1987) Response surfaces: design and analysis. Marcel Dekker, Inc, New York, USA"},{"key":"1281_CR30","volume-title":"Design and analysis of experiments","author":"DC Montgomery","year":"1997","unstructured":"Montgomery DC (1997) Design and analysis of experiments, 4th edn. Wiley, New York","edition":"4"},{"key":"1281_CR31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/MMBR.64.1.34-50.2000","volume":"64","author":"S Ostergaard","year":"2000","unstructured":"Ostergaard S, Olsson L, Nielsen J (2000) Metabolic engineering of Sacaharomyces cerevisiae. Microbiol Mol Biol Rev 64:34\u201350","journal-title":"Microbiol Mol Biol Rev"},{"key":"1281_CR32","first-page":"1","volume":"31","author":"B Hahn-Hagerdal","year":"2005","unstructured":"Hahn-Hagerdal B, Karhumaa K, Larsson CU, Gorwa-Grauslund M, Gorgens J, van Zyl W (2005) Role of cultivation media in the development of yeast strains for large scale industrial use. Microbial Cell Fact 31:1\u201316","journal-title":"Microbial Cell Fact"},{"key":"1281_CR33","first-page":"443","volume":"B43","author":"V Makinen","year":"1970","unstructured":"Makinen V, Haikara A, Enari T-M (1970) Influence of nitrogenous compounds on beer fermentation. Soum Kemistilehti B43:443\u2013447","journal-title":"Soum Kemistilehti"},{"key":"1281_CR34","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1128\/AEM.60.5.1519-1524.1994","volume":"60","author":"KC Thomas","year":"1994","unstructured":"Thomas KC, Hynes SH, Ingledew WM (1994) Effects of particulate materials and osmopotectants on very-high-gravity ethanolic fermentation by Saccharomyces cerevisiae. Appl Environ Microbiol 60:1519\u20131524","journal-title":"Appl Environ Microbiol"}],"container-title":["European Food Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00217-010-1281-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00217-010-1281-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00217-010-1281-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T01:52:22Z","timestamp":1591235542000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00217-010-1281-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,28]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["1281"],"URL":"https:\/\/doi.org\/10.1007\/s00217-010-1281-z","relation":{},"ISSN":["1438-2377","1438-2385"],"issn-type":[{"value":"1438-2377","type":"print"},{"value":"1438-2385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,28]]}}}