{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:52:14Z","timestamp":1777107134186,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s00228-024-03693-7","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T14:48:10Z","timestamp":1714574890000},"page":"1121-1132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Does the use of bisphosphonates during pregnancy affect fetal outcomes? A systematic review"],"prefix":"10.1007","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-3087","authenticated-orcid":false,"given":"Wladimir Gushiken","family":"de Campos","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-9990","authenticated-orcid":false,"given":"Rita","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-8346","authenticated-orcid":false,"given":"Vin\u00edcius","family":"Teixeira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-2123","authenticated-orcid":false,"given":"Pedro Sousa","family":"Gomes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-6719","authenticated-orcid":false,"given":"Celso Augusto","family":"Lemos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"3693_CR1","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1111\/bcp.13867","volume":"85","author":"S Cremers","year":"2019","unstructured":"Cremers S, Drake MT, Ebetino FH, Bilezikian JP, Russell RGG (2019) Pharmacology of bisphosphonates. Br J Clin Pharmacol 85:1052\u20131062","journal-title":"Br J Clin Pharmacol"},{"key":"3693_CR2","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.4065\/83.9.1032","volume":"83","author":"MT Drake","year":"2008","unstructured":"Drake MT, Clarke BL, Khosla S (2008) Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc 83:1032\u20131045","journal-title":"Mayo Clin Proc"},{"key":"3693_CR3","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/S0020-1383(16)30015-8","volume":"47","author":"SL Kates","year":"2016","unstructured":"Kates SL, Ackert-Bicknell CL (2016) How do bisphosphonates affect fracture healing? Injury 47:S65\u2013S68. https:\/\/doi.org\/10.1016\/S0020-1383(16)30015-8. Elsevier Ltd","journal-title":"Injury"},{"key":"3693_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/jcmm.12154","volume":"18","author":"V Ribeiro","year":"2014","unstructured":"Ribeiro V, Garcia M, Oliveira R, Gomes PS, Cola\u00e7o B, Fernandes MH (2014) Bisphosphonates induce the osteogenic gene expression in co-cultured human endothelial and mesenchymal stem cells. J Cell Mol Med 18:27\u201337","journal-title":"J Cell Mol Med"},{"key":"3693_CR5","doi-asserted-by":"publisher","first-page":"172773","DOI":"10.1016\/j.ejphar.2019.172773","volume":"866","author":"A Ku\u017anik","year":"2020","unstructured":"Ku\u017anik A, Pa\u017adzierniok-Holewa A, Jewula P, Ku\u017anik N (2020) Bisphosphonates-much more than only drugs for bone diseases. Eur J Pharmacol 866:172773. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172773. Epub 2019 Nov 6. PMID: 31705903","journal-title":"Eur J Pharmacol"},{"key":"3693_CR6","doi-asserted-by":"publisher","first-page":"116673","DOI":"10.1016\/j.taap.2023.116673","volume":"476","author":"WG de Campos","year":"2023","unstructured":"de Campos WG, Ara\u00fajo R, J\u00fanior CAL, de Sousa Gomes P (2023) Alendronate induces skeletal alterations in the chicken embryonic development model. Toxicol Appl Pharmacol 476:116673. https:\/\/doi.org\/10.1016\/j.taap.2023.116673. Elsevier Inc.","journal-title":"Toxicol Appl Pharmacol"},{"key":"3693_CR7","doi-asserted-by":"publisher","first-page":"110590","DOI":"10.1016\/j.mce.2019.110590","volume":"499","author":"L Clemente","year":"2020","unstructured":"Clemente L, Boeldt DS, Grummer MA, Morita M, Morgan TK, Wiepz GJ et al (2020) Adenoviral transduction of EGFR into pregnancy-adapted uterine artery endothelial cells remaps growth factor induction of endothelial dysfunction. Mol Cell Endocrinol 499:110590. https:\/\/doi.org\/10.1016\/j.mce.2019.110590. Elsevier","journal-title":"Mol Cell Endocrinol"},{"key":"3693_CR8","first-page":"68","volume":"60","author":"N Patlas","year":"1999","unstructured":"Patlas N, Golomb G, Yaffe P, Pinto T, Breuer E, Ornoy A (1999) Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology United States 60:68\u201373","journal-title":"Teratology United States"},{"key":"3693_CR9","first-page":"654","volume":"42","author":"P Graepel","year":"1992","unstructured":"Graepel P, Bentley P, Fritz H, Miyamoto M, Slater SR (1992) Reproduction toxicity studies with pamidronate. Arzneimittelforschung Germany 42:654\u2013667","journal-title":"Arzneimittelforschung Germany"},{"key":"3693_CR10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1006\/taap.1993.1148","volume":"121","author":"DH Minsker","year":"1993","unstructured":"Minsker DH, Manson JM, Peter CP (1993) Effects of the bisphosphonate, alendronate, on parturition in the rat. Toxicol Appl Pharmacol United States 121:217\u2013223","journal-title":"Toxicol Appl Pharmacol United States"},{"key":"3693_CR11","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.bone.2008.11.001","volume":"44","author":"S Levy","year":"2009","unstructured":"Levy S, Fayez I, Taguchi N, Han JY, Aiello J, Matsui D et al (2009) Pregnancy outcome following in utero exposure to bisphosphonates. Bone 44:428\u2013430. https:\/\/doi.org\/10.1016\/j.bone.2008.11.001. Elsevier Inc.","journal-title":"Bone"},{"key":"3693_CR12","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.reprotox.2006.05.009","volume":"22","author":"A Ornoy","year":"2006","unstructured":"Ornoy A, Wajnberg R, Diav-Citrin O (2006) The outcome of pregnancy following pre-pregnancy or early pregnancy alendronate treatment. Reprod Toxicol United States 22:578\u2013579","journal-title":"Reprod Toxicol United States"},{"issue":"10","key":"3693_CR13","first-page":"2127","volume":"18","author":"Z Munn","year":"2020","unstructured":"Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, Stephenson M, Aromataris E (2020) Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth 18(10):2127\u20132133","journal-title":"JBI Evid Synth"},{"key":"3693_CR14","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s00198-009-1138-0","volume":"21","author":"SR Mastaglia","year":"2010","unstructured":"Mastaglia SR, Watman NP, Oliveri B (2010) Intravenous bisphosphonate treatment and pregnancy: its effects on mother and infant bone health. Osteoporos Int England 21:1959\u20131962","journal-title":"Osteoporos Int England"},{"key":"3693_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.20945\/2359-3997000000016","volume":"62","author":"R Koren","year":"2018","unstructured":"Koren R, Neeman O, Koren S, Benbassat CA (2018) Humoral hypercalcemia of pregnancy treated with bisphosphonates. Arch Endocrinol Metab Brazil 62:125\u2013128","journal-title":"Arch Endocrinol Metab Brazil"},{"key":"3693_CR16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00198-018-4672-9","volume":"30","author":"A Sokal","year":"2019","unstructured":"Sokal A, Elefant E, Leturcq T, Beghin D, Mariette X, Seror R (2019) Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study. Osteoporos Int Osteoporosis International 30:221\u2013229","journal-title":"Osteoporos Int Osteoporosis International"},{"key":"3693_CR17","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1210\/jc.2005-2548","volume":"91","author":"B Chan","year":"2006","unstructured":"Chan B, Zacharin M (2006) Maternal and infant outcome after pamidronate treatment of polyostotic fibrous dysplasia and osteogenesis imperfecta before conception: a report of four cases. J Clin Endocrinol Metab 91:2017\u20132020","journal-title":"J Clin Endocrinol Metab"},{"key":"3693_CR18","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1359\/JBMR.040711","volume":"19","author":"CFJ Munns","year":"2004","unstructured":"Munns CFJ, Rauch F, Ward L, Glorieux FH (2004) Maternal and fetal outcome after long-term pamidronate treatment before conception: a report of two cases. J Bone Miner Res 19:1742\u20131745","journal-title":"J Bone Miner Res"},{"key":"3693_CR19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.autrev.2010.03.002","volume":"9","author":"I Losada","year":"2010","unstructured":"Losada I, Sartori L, Di Gianantonio E, Zen M, Clementi M, Doria A (2010) Bisphosphonates in patients with autoimmune rheumatic diseases: can they be used in women of childbearing age? Autoimmun Rev Netherlands 9:547\u2013552","journal-title":"Autoimmun Rev Netherlands"},{"key":"3693_CR20","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00296-011-1816-z","volume":"32","author":"N Vujasinovic-Stupar","year":"2012","unstructured":"Vujasinovic-Stupar N, Pejnovic N, Markovic L, Zlatanovic M (2012) Pregnancy-associated spinal osteoporosis treated with bisphosphonates: long-term follow-up of maternal and infants outcome. Rheumatol Int Germany 32:819\u2013823","journal-title":"Rheumatol Int Germany"},{"issue":"2","key":"3693_CR21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.tjog.2012.04.029","volume":"51","author":"CP Chen","year":"2012","unstructured":"Chen CP, Lin SP, Su YN, Huang JP, Chern SR, Su JW, Wang W (2012) Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception. Taiwan J Obstet Gynecol 51(2):305\u2013307. https:\/\/doi.org\/10.1016\/j.tjog.2012.04.029. PMID: 22795118","journal-title":"Taiwan J Obstet Gynecol"},{"key":"3693_CR22","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1007\/s00198-005-1986-1","volume":"16","author":"BA Barrera","year":"2005","unstructured":"Barrera BA, Wilton L, Harris S, Shakir SAW (2005) Prescription-event monitoring study on 13,164 patients prescribed risedronate in primary care in England. Osteoporos Int 16:1989\u20131998","journal-title":"Osteoporos Int"},{"key":"3693_CR23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00404-007-0321-9","volume":"276","author":"S Athimulam","year":"2007","unstructured":"Athimulam S, Chan P, Baker M, Nauta M, Yoong W (2007) The effect of pregnancy on pre-existing osteopenia: a case report. Arch Gynecol Obstet Germany 276:175\u2013177","journal-title":"Arch Gynecol Obstet Germany"},{"key":"3693_CR24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00198-003-1399-y","volume":"14","author":"PN Biswas","year":"2003","unstructured":"Biswas PN, Wilton LV, Shakir SAW (2003) Pharmacovigilance study of alendronate in England. Osteoporos Int England 14:507\u2013514","journal-title":"Osteoporos Int England"},{"key":"3693_CR25","doi-asserted-by":"publisher","unstructured":"Machairiotis N, Ntali G, Kouroutou P, Michala L (2019) Clinical evidence of the effect of bisphosphonates on pregnancy and the infant. Horm Mol Biol Clin Investig 40(2). https:\/\/doi.org\/10.1515\/hmbci-2019-0021. PMID: 31539355","DOI":"10.1515\/hmbci-2019-0021"},{"key":"3693_CR26","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.2146\/ajhp140041","volume":"71","author":"SB Green","year":"2014","unstructured":"Green SB, Papas AL (2014) Effects of maternal bisphosphonate use on fetal and neonatal outcomes. Am J Heal Pharm 71:2029\u20132036","journal-title":"Am J Heal Pharm"},{"key":"3693_CR27","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00393-021-01028-w","volume":"80","author":"J Leipe","year":"2021","unstructured":"Leipe J, Holle JU, Weseloh C, Pfeil A, Kr\u00fcger K (2021) German society of rheumatology recommendations for the management of glucocorticoid-induced osteoporosis. German version. Z Rheumatol Germany 80:670\u201387","journal-title":"Z Rheumatol Germany"},{"key":"3693_CR28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/jwh.2008.0887","volume":"18","author":"A Cohen","year":"2009","unstructured":"Cohen A, Fleischer J, Freeby MJ, McMahon DJ, Irani D, Shane E (2009) Clinical characteristics and medication use among premenopausal women with osteoporosis and low BMD: The experience of an osteoporosis referral center. J Women\u2019s Heal 18:79\u201384","journal-title":"J Women\u2019s Heal"},{"issue":"4","key":"3693_CR29","doi-asserted-by":"publisher","first-page":"280","DOI":"10.14310\/horm.2002.1319","volume":"10","author":"IP Stathopoulos","year":"2011","unstructured":"Stathopoulos IP, Liakou CG, Katsalira A, Trovas G, Lyritis GG, Papaioannou NA, Tournis S (2011) The use of bisphosphonates in women prior to or during pregnancy and lactation. Hormones (Athens) 10(4):280\u2013291. https:\/\/doi.org\/10.14310\/horm.2002.1319. PMID: 22281884","journal-title":"Hormones (Athens)"},{"key":"3693_CR30","first-page":"1243","volume":"72","author":"CP Griebel","year":"2005","unstructured":"Griebel CP, Halvorsen J, Golemon TB, Day AA (2005) Management of spontaneous abortion. Am Fam Physician 72:1243\u20131250","journal-title":"Am Fam Physician"},{"key":"3693_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-017-1620-1","volume":"17","author":"JS Cohain","year":"2017","unstructured":"Cohain JS, Buxbaum RE, Mankuta D (2017) Spontaneous first trimester miscarriage rates per woman among parous women with 1 or more pregnancies of 24 weeks or more. BMC Pregnancy Childbirth 17:1\u20137","journal-title":"BMC Pregnancy Childbirth"},{"key":"3693_CR32","doi-asserted-by":"publisher","first-page":"4871494","DOI":"10.1155\/2020\/4871494","volume":"2020","author":"M Moradinazar","year":"2020","unstructured":"Moradinazar M, Najafi F, Nazar ZM, Hamzeh B, Pasdar Y, Shakiba E (2020) Lifetime prevalence of abortion and risk factors in women: Evidence from a cohort study. J Pregnancy 2020:4871494. https:\/\/doi.org\/10.1155\/2020\/4871494. PMID: 32395342;\u00a0PMCID: PMC7201453","journal-title":"J Pregnancy"},{"key":"3693_CR33","first-page":"25","volume":"25","author":"G Corsello","year":"2012","unstructured":"Corsello G, Giuffr\u00e8 M (2012) Congenital malformations J Matern Neonatal Med 25:25\u201329","journal-title":"Congenital malformations J Matern Neonatal Med"},{"key":"3693_CR34","doi-asserted-by":"publisher","first-page":"86","DOI":"10.6065\/apem.2015.20.2.86","volume":"20","author":"WI Cho","year":"2015","unstructured":"Cho WI, Yu HW, Chung HR, Shin CH, Yang SW, Choi CW et al (2015) Clinical and laboratory characteristics of neonatal hypocalcemia. Ann Pediatr Endocrinol Metab 20:86","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"3693_CR35","doi-asserted-by":"publisher","first-page":"4318075","DOI":"10.1155\/2019\/4318075","volume":"2019","author":"D Vuralli","year":"2019","unstructured":"Vuralli D (2019) Clinical Approach to hypocalcemia in newborn period and infancy: Who should be treated? Int J Pediatr 2019:4318075. https:\/\/doi.org\/10.1155\/2019\/4318075. PMID: 31320908; PMCID: PMC6607701","journal-title":"Int J Pediatr"},{"issue":"6","key":"3693_CR36","doi-asserted-by":"publisher","first-page":"e1461","DOI":"10.1542\/peds.2011-2659","volume":"129","author":"TC Thomas","year":"2012","unstructured":"Thomas TC, Smith JM, White PC, Adhikari S (2012) Transient neonatal hypocalcemia: presentation and outcomes. Pediatrics 129(6):e1461\u2013e1467. https:\/\/doi.org\/10.1542\/peds.2011-2659. Epub 2012 May 21. PMID: 22614771","journal-title":"Pediatrics"},{"key":"3693_CR37","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00774-009-0119-x","volume":"27","author":"G Liamis","year":"2009","unstructured":"Liamis G, Milionis HJ, Elisaf M (2009) A review of drug-induced hypocalcemia. J Bone Miner Metab 27:635\u2013642","journal-title":"J Bone Miner Metab"},{"key":"3693_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2018.04.003","volume":"52","author":"JP Vogel","year":"2018","unstructured":"Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P (2018) The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol 52:3\u201312. https:\/\/doi.org\/10.1016\/j.bpobgyn.2018.04.003. Elsevier Ltd","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"3693_CR39","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","volume":"379","author":"H Blencowe","year":"2012","unstructured":"Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379:2162\u20132172. https:\/\/doi.org\/10.1016\/S0140-6736(12)60820-4. Elsevier Ltd","journal-title":"Lancet"},{"key":"3693_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1758-5996-5-49","volume":"5","author":"CA Negrato","year":"2013","unstructured":"Negrato CA, Gomes MB (2013) Low birth weight: causes and consequences. Diabetol Metab Syndr 5:1\u20138","journal-title":"Diabetol Metab Syndr"},{"issue":"7","key":"3693_CR41","doi-asserted-by":"publisher","first-page":"e40040","DOI":"10.1371\/journal.pone.0040040","volume":"7","author":"CS Metgud","year":"2012","unstructured":"Metgud CS, Naik VA, Mallapur MD (2012) Factors affecting birth weight of a newborn\u2013a community based study in rural Karnataka, India. PLoS One 7(7):e40040. https:\/\/doi.org\/10.1371\/journal.pone.0040040. Epub 2012 Jul 5. PMID: 22792210; PMCID: PMC3390317","journal-title":"PLoS One"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-024-03693-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-024-03693-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-024-03693-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T07:05:46Z","timestamp":1720163146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-024-03693-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3693"],"URL":"https:\/\/doi.org\/10.1007\/s00228-024-03693-7","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]},"assertion":[{"value":"25 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}