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Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric hospitals between January 2010 and March 2022. Subjects with first available brain MRI and <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\ge$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mo>\u2265<\/mml:mo>\n                  <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 3\u00a0months of clinical follow-up were included. Neuroimaging studies were reviewed, and clinical data collected. Annual symptomatic hemorrhage risk rates and cumulative risks were calculated using survival analysis and predictors of symptomatic hemorrhagic identified using regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty-one children (53.7% males) were included, of whom 15 (36.3%) presenting with symptomatic hemorrhage. Seven symptomatic hemorrhages occurred during 140.5 person-years of follow-up, yielding a 5-year annual hemorrhage rate of 5.0% per person-year. The 1-, 2-, and 5-year cumulative risks of symptomatic hemorrhage were 7.3%, 14.6%, and 17.1%, respectively. The latter was higher in children with prior symptomatic hemorrhage (33.3%), <jats:italic>CCM2<\/jats:italic> genotype (33.3%), and positive family history (20.7%). Number of brainstem (adjusted hazard ratio [HR]\u2009=\u20091.37, <jats:italic>P<\/jats:italic>\u2009=\u20090.005) and posterior fossa (adjusted HR\u2009=\u20091.64, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) CCM at first brain MRI were significant independent predictors of prospective symptomatic hemorrhage.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The 5-year annual and cumulative symptomatic hemorrhagic risk in our pediatric FCCM cohort equals the overall risk described in children and adults with all types of CCM. Imaging features at first brain MRI may help to predict potential symptomatic hemorrhage at 5-year follow-up.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00234-022-03056-y","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T01:02:46Z","timestamp":1665018166000},"page":"401-414","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9663-4387","authenticated-orcid":false,"given":"Ana Filipa","family":"Geraldo","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5877-9086","authenticated-orcid":false,"given":"Cesar Augusto P. 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