{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T23:29:41Z","timestamp":1769902181595,"version":"3.49.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T00:00:00Z","timestamp":1349481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Environ Contam Toxicol"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00244-012-9812-1","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T09:07:15Z","timestamp":1349428035000},"page":"97-109","source":"Crossref","is-referenced-by-count":23,"title":["Ecotoxicological Heterogeneity in Transitional Coastal Habitats Assessed Through the Integration of Biomarkers and Sediment-Contamination Profiles: A Case Study Using a Commercial Clam"],"prefix":"10.1007","volume":"64","author":[{"given":"S.","family":"Carreira","sequence":"first","affiliation":[]},{"given":"P. M.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"M.","family":"Martins","sequence":"additional","affiliation":[]},{"given":"J.","family":"Lobo","sequence":"additional","affiliation":[]},{"given":"M. H.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"S.","family":"Caeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,10,6]]},"reference":[{"key":"9812_CR1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7773\/cm.v31i12.97","volume":"31","author":"LA Barreira","year":"2005","unstructured":"Barreira LA, Bebianno MJ, Mudge SM, Ferreira AM, Albino CI, Veriato LM (2005) Relationship between PCBs in suspended and settled sediments from a coastal lagoon. Cienc Mar 31:179\u2013195","journal-title":"Cienc Mar"},{"key":"9812_CR200","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/15275920701506359","volume":"8","author":"LA Barreira","year":"2007","unstructured":"Barreira LA, Mudge SM, Bebianno MJ (2007) Concentrations and sources of polycyclic aromatic hydrocarbons in sediments from the Ria Formosa lagoon. Environ Forens 8:231\u2013243","journal-title":"Environ Forens"},{"key":"9812_CR2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00244-002-2004-7","volume":"44","author":"MJ Bebianno","year":"2003","unstructured":"Bebianno MJ, Serafim MA (2003) Variation of metallothionein and metal concentrations in a natural clam population of Ruditapes decussatus. Arch Environ Contam Toxicol 44:53\u201356","journal-title":"Arch Environ Contam Toxicol"},{"key":"9812_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/13547500400017820","volume":"9","author":"MJ Bebianno","year":"2004","unstructured":"Bebianno MJ, G\u00e9ret F, Hoarau P, Serafim MA, Coelho MR, Gnassia e Barelli M et al (2004) Biomarkers in Ruditapes decussatus: a potential bioindicator species. Biomarkers 9:305\u2013330","journal-title":"Biomarkers"},{"key":"9812_CR4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.aquatox.2005.08.013","volume":"75","author":"MJ Bebianno","year":"2005","unstructured":"Bebianno MJ, Company R, Serafim A, Cosson RP, Fiala-Medoni A (2005) Antioxidant systems and lipid peroxidation in Bathymodiolus azoricus from Mid Atlantic Ridge hydrothermal vent fields. Aquat Toxicol 75:354\u2013373","journal-title":"Aquat Toxicol"},{"key":"9812_CR5","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ecoenv.2008.09.012","volume":"72","author":"H Bergayou","year":"2009","unstructured":"Bergayou H, Mouneyrac C, Pellerin J, Moukrim A (2009) Oxidative stress responses in bivalves (Scrobicularia plana, Cerastoderma edule) from the Oued Souss estuary (Morocco). Ecotoxicol Environ Safe 72:765\u2013769","journal-title":"Ecotoxicol Environ Safe"},{"key":"9812_CR6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.chemosphere.2006.03.049","volume":"65","author":"R Bocchetti","year":"2006","unstructured":"Bocchetti R, Regoli F (2006) Seasonal variability of oxidative biomarkers, lysosomal parameters, metallothioneins and peroxisomal enzymes in the Mediterranean mussel Mytilus galloprovincialis from Adriatic Sea. Chemosphere 65:913\u2013921","journal-title":"Chemosphere"},{"key":"9812_CR7","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.marpolbul.2010.09.026","volume":"60","author":"\u00c1 Borja","year":"2010","unstructured":"Borja \u00c1, Elliott M, Carstensen J, Heiskanen A-S, van de Bund W (2010) Marine management\u2014towards an integrated implementation of the European Marine Strategy Framework and the Water Framework Directives. Mar Pollut Bull 60:2175\u20132186","journal-title":"Mar Pollut Bull"},{"key":"9812_CR8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"9812_CR9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ecolind.2005.02.001","volume":"5","author":"S Caeiro","year":"2005","unstructured":"Caeiro S, Costa MH, Ramos TB, Fernandes F, Silveira N, Coimbra A, Medeiros G et al (2005) Assessing heavy metal contamination in Sado Estuary sediment: an index analysis approach. Ecol Indic 5:151\u2013169","journal-title":"Ecol Indic"},{"key":"9812_CR10","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s10646-009-0372-8","volume":"18","author":"S Caeiro","year":"2009","unstructured":"Caeiro S, Costa MH, DelValls A, Repolho T, Gon\u00e7alves M, Mosca A et al (2009) Ecological risk assessment of sediment management areas: application to Sado estuary, Portugal. Ecotoxicology 18:1165\u20131175","journal-title":"Ecotoxicology"},{"key":"9812_CR11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.scitotenv.2006.11.026","volume":"380","author":"M Caetano","year":"2007","unstructured":"Caetano M, Fonseca N, Ces\u00e1rio R, Vale C (2007) Mobility of Pb in saltmarshes recorded by total content and stable isotopic signature. Sci Total Environ 380:84\u201392","journal-title":"Sci Total Environ"},{"key":"9812_CR12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.marenvres.2012.01.001","volume":"77","author":"C Carballeira","year":"2012","unstructured":"Carballeira C, Ramos-G\u00f3mez J, Mart\u00edn-D\u00edaz L, DelValls TA (2012) Identification of specific malformations of sea urchin larvae for toxicity assessment: application to marine pisciculture effluents. Mar Environ Res 77:12\u201322","journal-title":"Mar Environ Res"},{"key":"9812_CR13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1065\/jss2006.01.152","volume":"6","author":"PM Chapman","year":"2006","unstructured":"Chapman PM, Hollert H (2006) Should the sediment quality triad become a tetrad, a pentad or possibly even a hexad? J Soils Sed 6:4\u20138","journal-title":"J Soils Sed"},{"key":"9812_CR14","first-page":"283","volume-title":"Handbook of methods of oxygen radical research","author":"A Clairborne","year":"1985","unstructured":"Clairborne A (1985) Catalase activity. In: Grenwald RA (ed) Handbook of methods of oxygen radical research. CRC Press, Boca Raton, pp 283\u2013284"},{"key":"9812_CR15","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/aoc.313","volume":"16","author":"MR Coelho","year":"2002","unstructured":"Coelho MR, Bebianno MJ, Lansgton WJ (2002) Organotin levels in the Ria Formosa lagoon, Portugal. Appl Organomet Chem 16:384\u2013390","journal-title":"Appl Organomet Chem"},{"key":"9812_CR16","first-page":"295","volume":"46","author":"RP Cosson","year":"2000","unstructured":"Cosson RP (2000) Bivalve metallothioneins as a biomarker of aquatic ecosystem pollution by trace metals: limits and perspectives. Cell Mol Biol 46:295\u2013309","journal-title":"Cell Mol Biol"},{"key":"9812_CR17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ecoenv.2007.05.012","volume":"71","author":"PM Costa","year":"2008","unstructured":"Costa PM, Repolho T, Caeiro S, Diniz ME, Moura I, Costa MH (2008) Modelling metallothionein induction in the liver of Sparus aurata exposed to metal-contaminated estuarine sediments. Ecotoxicol Environ Safe 71:117\u2013124","journal-title":"Ecotoxicol Environ Safe"},{"key":"9812_CR18","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1007\/s10646-009-0373-7","volume":"18","author":"PM Costa","year":"2009","unstructured":"Costa PM, Caeiro S, Diniz MS, Lobo J, Martins M, Ferreira A et al (2009) Biochemical endpoints on juvenile Solea senegalensis exposed to estuarine sediments: the effect of contaminant mixtures on metallothionein and CYP1A induction. Ecotoxicology 18:988\u20131000","journal-title":"Ecotoxicology"},{"key":"9812_CR19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.marpolbul.2010.09.009","volume":"62","author":"PM Costa","year":"2011","unstructured":"Costa PM, Caeiro S, Lobo J, Martins M, Ferreira AM, Caetano M et al (2011) Estuarine ecological risk based on hepatic histopathological indices from laboratory and in situ tested fish. Mar Pollut Bull 62:55\u201365","journal-title":"Mar Pollut Bull"},{"key":"9812_CR20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.envpol.2011.10.010","volume":"161","author":"PM Costa","year":"2012","unstructured":"Costa PM, Caeiro S, Vale C, DellValls T\u00c0, Costa MH (2012) Can the integration of multiple biomarkers and sediment geochemistry aid solving the complexity of sediment risk assessment? A case study with a benthic fish. Environ Pollut 161:107\u2013120","journal-title":"Environ Pollut"},{"key":"9812_CR21","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1039\/b909846a","volume":"11","author":"A Cravo","year":"2009","unstructured":"Cravo A, Lopes B, Serafim A, Company R, Barreira L, Gomes T et al (2009) A multibiomarker approach in Mytilus galloprovincialis to assess environmental quality. J Environ Monit 11:1673\u201316864","journal-title":"J Environ Monit"},{"key":"9812_CR22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.marenvres.2011.09.012","volume":"75","author":"A Cravo","year":"2012","unstructured":"Cravo A, Pereira C, Gomes T, Cardoso C, Serafim A, Almeida C et al (2012) A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal. Mar Environ Res 75:23\u201334","journal-title":"Mar Environ Res"},{"key":"9812_CR23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.envpol.2006.03.050","volume":"145","author":"RJ Dean","year":"2007","unstructured":"Dean RJ, Shimmield TM, Black KD (2007) Copper, zinc and cadmium in marine cage fish farm sediments: an extensive survey. Environ Pollut 145:84\u201395","journal-title":"Environ Pollut"},{"key":"9812_CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-4203(03)00111-7","volume":"89","author":"AM Ferreira","year":"2003","unstructured":"Ferreira AM, Martins M, Vale C (2003) Influence of diffuse sources on levels and distribution of polychlorinated biphenyls in the Guadiana River estuary (Portugal). Mar Chem 89:175\u2013184","journal-title":"Mar Chem"},{"key":"9812_CR25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ecoenv.2005.01.004","volume":"61","author":"A Geffard","year":"2005","unstructured":"Geffard A, Amiard-Triquet C, Amiard JC (2005) Do seasonal changes affect metallothionein induction by metals in mussels, Mytilus edulis? Ecotoxicol Environ Safe 61:209\u2013220","journal-title":"Ecotoxicol Environ Safe"},{"key":"9812_CR26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1023\/A:1026108306755","volume":"12","author":"F Geret","year":"2003","unstructured":"Geret F, Serafim A, Bebianno MJ (2003) Antioxidant enzyme activities, metallothioneins and lipid peroxidation as biomarkers in Ruditapes decussatus? Ecotoxicology 12:417\u2013426","journal-title":"Ecotoxicology"},{"key":"9812_CR27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1023\/A:1009961901782","volume":"33","author":"O Gil","year":"1999","unstructured":"Gil O, Vale C (1999) DDT concentrations in surficial sediments of three estuarine systems in Portugal. Aquat Ecol 33:263\u2013269","journal-title":"Aquat Ecol"},{"key":"9812_CR28","first-page":"153","volume":"123","author":"A Hamza-Chaffai","year":"1999","unstructured":"Hamza-Chaffai A, Amiard JC, Cosson RP (1999) Relationship between metallothioneins and metals in a natural population of the clam Ruditapes decussatus from Sfax coast: a non-linear model using Box\u2013Cox transformation. Comp Biochem Physiol C 123:153\u2013163","journal-title":"Comp Biochem Physiol C"},{"key":"9812_CR29","first-page":"185","volume":"127","author":"A Hamza-Chaffai","year":"2000","unstructured":"Hamza-Chaffai A, Amiard JC, Pellerin J, Joux L, Berthat B (2000) The potential use of metallothionein in the clam, Ruditapes decussatus as a biomarker of in situ metal exposure. Comp Biochem Physiol C 127:185\u2013197","journal-title":"Comp Biochem Physiol C"},{"key":"9812_CR30","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1080\/10807039891284956","volume":"4","author":"ER Long","year":"1998","unstructured":"Long ER, MacDonald DD (1998) Recommended uses of empirically derived, sediment quality guidelines for marine and estuarine ecosystems. Hum Ecol Risk Assess 4:1019\u20131039","journal-title":"Hum Ecol Risk Assess"},{"key":"9812_CR31","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.marpolbul.2010.06.005","volume":"60","author":"BP Lyons","year":"2010","unstructured":"Lyons BP, Thain JE, Stentiford GD, Hylland K, Davies IM, Vethaak AD (2010) Using biological effects tools to define good environmental status under the European Union Marine Strategy Framework Directive. Mar Pollut Bull 60:1647\u20131651","journal-title":"Mar Pollut Bull"},{"key":"9812_CR32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00118995","volume":"5","author":"DD MacDonald","year":"1996","unstructured":"MacDonald DD, Carr S, Clader FD, Long ED, Ingersoll CG (1996) Development and evaluation of sediment quality guidelines for Florida coastal waters. Ecotoxicology 5:253\u2013278","journal-title":"Ecotoxicology"},{"key":"9812_CR33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00244-003-2270-z","volume":"46","author":"DD MacDonald","year":"2004","unstructured":"MacDonald DD, Carr RS, Eckenrod D, Greening H, Grabe S, Ingersoll CG et al (2004) Development, evaluation, and application of sediment quality targets for assessing and managing contaminated sediments in Tampa Bay, Florida. Arch Environ Contam Toxicol 46:147\u2013161","journal-title":"Arch Environ Contam Toxicol"},{"key":"9812_CR34","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1007\/s10646-009-0361-y","volume":"18","author":"VL Maria","year":"2009","unstructured":"Maria VL, Santos MA, Bebianno MJ (2009) Biomarkers of damage and protection in Mytilus galloprovincialis cross transplanted in Ria Formosa Lagoon (Portugal). Ecotoxicology 18:1018\u20131028","journal-title":"Ecotoxicology"},{"key":"9812_CR35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.trac.2004.07.012","volume":"23","author":"ML Mart\u00edn-D\u00edaz","year":"2004","unstructured":"Mart\u00edn-D\u00edaz ML, Blasco J, Sales D, DelValls TA (2004) Biomarkers as tools to assess sediment quality. Laboratory and field surveys. Trends Anal Chem 23:807\u2013818","journal-title":"Trends Anal Chem"},{"key":"9812_CR36","doi-asserted-by":"crossref","unstructured":"Martins M, Costa PM, Raimundo J, Vale C, Ferreira AM, Costa MH (2012) Impact of remobilized contaminants in Mytilus edulis during dredging operations in a harbour area: Bioaccumulation and biomarker responses. Ecotoxicol Environ Safe 85:96\u2013103","DOI":"10.1016\/j.ecoenv.2012.08.008"},{"key":"9812_CR37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10499-008-9197-3","volume":"17","author":"D Matias","year":"2009","unstructured":"Matias D, Joaquim S, Leit\u00e3o A, Massapina C (2009) Effect of geographic origin, temperature and timing of broodstock collection on conditioning, spawning success and larval viability of Ruditapes decussatus. Aquacult Int 17:257\u2013271","journal-title":"Aquacult Int"},{"key":"9812_CR38","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/pmic.201100417","volume":"12","author":"S Muralidharan","year":"2012","unstructured":"Muralidharan S, Thompson E, Raftos D, Birch G, Haynes PA (2012) Quantitative proteomics of heavy metal stress responses in Sydney rock oysters. Proteomics 12:906\u2013921","journal-title":"Proteomics"},{"key":"9812_CR39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0027-5107(87)90222-3","volume":"180","author":"T Ochi","year":"1987","unstructured":"Ochi T, Takahashi K, Ohsawa M (1987) Indirect evidence for the induction of a pro-oxidant state by cadmium chloride in cultured mammalian cells and a possible mechanism for the induction. Mutat Res 180:257\u2013266","journal-title":"Mutat Res"},{"key":"9812_CR40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0003-2697(71)90010-8","volume":"42","author":"E Pale\u010dek","year":"1971","unstructured":"Pale\u010dek E, Pechan Z (1971) Estimation of nanogram quantities of proteins by pulse polographic techniques. Anal Biochem 42:59\u201371","journal-title":"Anal Biochem"},{"key":"9812_CR41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2166\/wst.1987.0166","volume":"19","author":"MAS Pereira","year":"1987","unstructured":"Pereira MAS, Machado L (1987) Environment impact assessment of the discharge of effluent from the Faro waste stabilization ponds into the Ria Formosa, Algarve, Portugal. Water Sci Technol 19:337\u2013339","journal-title":"Water Sci Technol"},{"key":"9812_CR42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0269-7491(00)00104-4","volume":"112","author":"C Porte","year":"2001","unstructured":"Porte C, Biosca X, Sol\u00e9 M, Albaig\u00e9s J (2001) The integrated use of chemical analysis, cytochrome P450 and stress proteins in mussels to assess pollution along the Galician Coast (NW Spain). Environ Pollut 112:261\u2013268","journal-title":"Environ Pollut"},{"key":"9812_CR43","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1897\/1551-5028(2000)019<2239:EOHMAM>2.3.CO;2","volume":"19","author":"C Risso-de Faverney","year":"2000","unstructured":"Risso-de Faverney C, Lafaurie M, Girard J-P, Rahmani R (2000) Effects of heavy metals and 3-methylcholanthrene on expression and induction of CYP1A1 and metallothionein levels in trout (Oncorhynchus mykiss) hepatocyte cultures. Environ Toxicol Chem 19:2239\u20132248","journal-title":"Environ Toxicol Chem"},{"key":"9812_CR44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquatox.2006.05.005","volume":"79","author":"B Rocher","year":"2006","unstructured":"Rocher B, Le Goff J, Peluhet L, Birand M, Manduzio H, Gallois J et al (2006) Genotoxicant accumulation and cellular defence activation in bivalves chronically exposed to waterborne contaminants from the Seine River. Aquat Toxicol 79:65\u201377","journal-title":"Aquat Toxicol"},{"key":"9812_CR45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1289\/ehp.94102s1291","volume":"102","author":"G Roesijadi","year":"1994","unstructured":"Roesijadi G (1994) Metallothionein induction as a measure of response to metal exposure in aquatic animals. Environ Health Perspect 102:91\u201396","journal-title":"Environ Health Perspect"},{"key":"9812_CR46","volume-title":"Handbook of parametric and nonparametric statistical procedures","author":"FJ Sheskin","year":"2000","unstructured":"Sheskin FJ (2000) Handbook of parametric and nonparametric statistical procedures, 2nd edn. Chapman & Hall, Boca Raton","edition":"2"},{"key":"9812_CR47","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jat.784","volume":"21","author":"E Tatrai","year":"2001","unstructured":"Tatrai E, Kovacikova Z, Hudak A, Adamis Z, Ungvary G (2001) Comparative in vitro toxicity of cadmium and lead on redox cycling in type II pneumocytes. J Appl Toxicol 21:479\u2013483","journal-title":"J Appl Toxicol"},{"key":"9812_CR48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Uchiyama","year":"1978","unstructured":"Uchiyama M, Mihara M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271\u2013278","journal-title":"Anal Biochem"},{"key":"9812_CR49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","volume":"13","author":"R Oost Van der","year":"2003","unstructured":"Van der Oost R, Beyer J, Vermeulen NPE (2003) Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ Toxicol Pharmacol 13:57\u2013149","journal-title":"Environ Toxicol Pharmacol"},{"key":"9812_CR50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.scitotenv.2006.12.048","volume":"374","author":"RP Vasconcelos","year":"2007","unstructured":"Vasconcelos RP, Reis-Santos P, Fonseca V, Maia A, Ruano M et al (2007) Assessing anthropogenic pressures on estuarine fish nurseries along the Portuguese coast: a multi-metric index and conceptual approach. Sci Total Environ 374:199\u2013215","journal-title":"Sci Total Environ"},{"key":"9812_CR51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/135475099230615","volume":"4","author":"A Viarengo","year":"1999","unstructured":"Viarengo A, Burlando B, Dondero F, Marro A, Fabbri R (1999) Metallothionein as a tool in biomonitoring programmes. Biomarkers 4:455\u2013466","journal-title":"Biomarkers"},{"key":"9812_CR52","first-page":"407","volume":"46","author":"A Viarengo","year":"2000","unstructured":"Viarengo A, Burlando B, Ceratto N, Panfoli I (2000) Antioxidant role of metallothioneins: a comparative overview. Cell Mol Biol 46:407\u2013417","journal-title":"Cell Mol Biol"},{"key":"9812_CR53","first-page":"281","volume":"146","author":"A Viarengo","year":"2007","unstructured":"Viarengo A, Lowe D, Bolognesi C, Fabbri E, Koehler A (2007) The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. Comp Biochem Physiol C 146:281\u2013300","journal-title":"Comp Biochem Physiol C"},{"key":"9812_CR54","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.marpolbul.2007.05.018","volume":"54","author":"T Vlahogianni","year":"2007","unstructured":"Vlahogianni T, Dassenakis M, Scoullos MJ, Valavanidis A (2007) Integrated use of biomarkers (superoxide dismutase, catalase and lipid peroxidation) in mussels Mytilus galloprovincialis for assessing heavy metals pollution in coastal areas from the Saronikos Gulf of Greece. Mar Pollut Bull 54:1361\u20131371","journal-title":"Mar Pollut Bull"},{"key":"9812_CR55","volume-title":"Biostatistical analysis","author":"JH Zar","year":"1999","unstructured":"Zar JH (1999) Biostatistical analysis, 4th edn. Prentice Hall, Upper Saddle River","edition":"4"}],"container-title":["Archives of Environmental Contamination and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00244-012-9812-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00244-012-9812-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00244-012-9812-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T13:24:21Z","timestamp":1594733061000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00244-012-9812-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,6]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["9812"],"URL":"https:\/\/doi.org\/10.1007\/s00244-012-9812-1","relation":{},"ISSN":["0090-4341","1432-0703"],"issn-type":[{"value":"0090-4341","type":"print"},{"value":"1432-0703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,6]]}}}